pTNI20 program activity among T/NK/ILC cells

Activation of pTNI20
pTNI20 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI20 by different cell subtypes
pTNI20 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI20 top program genes

Top genes of pTNI20 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI20 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI20
pTNI20 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006955 immune response 1.17590061633592e-09 2311 41 25 0.609756097560976 0.0108178277801817
GO:BP GO:0002376 immune system process 1.45980035242006e-06 3278 41 25 0.609756097560976 0.00762660158633313
GO:BP GO:0045087 innate immune response 1.18801571420491e-05 998 54 16 0.296296296296296 0.0160320641282565
GO:BP GO:0006952 defense response 1.18801571420491e-05 1818 41 18 0.439024390243902 0.0099009900990099
GO:BP GO:0002682 regulation of immune system process 3.66480262275488e-05 1617 23 12 0.521739130434783 0.00742115027829314
GO:BP GO:0070383 DNA cytosine deamination 3.66480262275488e-05 10 89 4 0.0449438202247191 0.4
GO:BP GO:0046087 cytidine metabolic process 3.66480262275488e-05 11 89 4 0.0449438202247191 0.363636363636364
GO:BP GO:0006216 cytidine catabolic process 3.66480262275488e-05 11 89 4 0.0449438202247191 0.363636363636364
GO:BP GO:0051707 response to other organism 3.66480262275488e-05 1592 41 16 0.390243902439024 0.0100502512562814
GO:BP GO:0043207 response to external biotic stimulus 3.66480262275488e-05 1594 41 16 0.390243902439024 0.0100376411543287
GO:BP GO:0009972 cytidine deamination 3.66480262275488e-05 11 89 4 0.0449438202247191 0.363636363636364
GO:BP GO:0009607 response to biotic stimulus 3.7166725533475e-05 1626 41 16 0.390243902439024 0.00984009840098401
GO:BP GO:0098542 defense response to other organism 4.0034725324283e-05 1218 41 14 0.341463414634146 0.0114942528735632
GO:BP GO:0016554 cytidine to uridine editing 4.2131764461955e-05 12 89 4 0.0449438202247191 0.333333333333333
GO:BP GO:0046131 pyrimidine ribonucleoside metabolic process 5.09943655347044e-05 13 89 4 0.0449438202247191 0.307692307692308
GO:BP GO:0046133 pyrimidine ribonucleoside catabolic process 5.09943655347044e-05 13 89 4 0.0449438202247191 0.307692307692308
GO:BP GO:0045006 DNA deamination 6.36375854440338e-05 14 89 4 0.0449438202247191 0.285714285714286
GO:BP GO:0006954 inflammatory response 6.69811642627698e-05 794 39 11 0.282051282051282 0.0138539042821159
GO:BP GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate 9.91787807513942e-05 16 89 4 0.0449438202247191 0.25
GO:BP GO:0050776 regulation of immune response 0.000179932879867418 996 23 9 0.391304347826087 0.00903614457831325
GO:BP GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate 0.000183789402002049 19 89 4 0.0449438202247191 0.210526315789474
GO:BP GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate 0.000211921966394059 20 89 4 0.0449438202247191 0.2
GO:BP GO:0016553 base conversion or substitution editing 0.000211921966394059 20 89 4 0.0449438202247191 0.2
GO:BP GO:0032101 regulation of response to external stimulus 0.000230792939752992 1051 23 9 0.391304347826087 0.00856327307326356
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.000240036146276965 2255 41 17 0.414634146341463 0.00753880266075388
GO:BP GO:0048583 regulation of response to stimulus 0.000272712372677573 4278 23 16 0.695652173913043 0.0037400654511454
GO:BP GO:0046135 pyrimidine nucleoside catabolic process 0.000272712372677573 22 89 4 0.0449438202247191 0.181818181818182
GO:BP GO:0042454 ribonucleoside catabolic process 0.000295591124104597 23 89 4 0.0449438202247191 0.173913043478261
GO:BP GO:0070098 chemokine-mediated signaling pathway 0.000295591124104597 87 51 5 0.0980392156862745 0.0574712643678161
GO:BP GO:0072527 pyrimidine-containing compound metabolic process 0.000343107800723077 84 96 6 0.0625 0.0714285714285714
GO:BP GO:0045071 negative regulation of viral genome replication 0.000394893879167434 54 89 5 0.0561797752808989 0.0925925925925926
GO:BP GO:0010528 regulation of transposition 0.000401513876135532 26 89 4 0.0449438202247191 0.153846153846154
GO:BP GO:1990869 cellular response to chemokine 0.000401513876135532 97 51 5 0.0980392156862745 0.0515463917525773
GO:BP GO:1990868 response to chemokine 0.000401513876135532 97 51 5 0.0980392156862745 0.0515463917525773
GO:BP GO:0010529 negative regulation of transposition 0.000401513876135532 26 89 4 0.0449438202247191 0.153846153846154
GO:BP GO:0048247 lymphocyte chemotaxis 0.000492047265994858 63 82 5 0.0609756097560976 0.0793650793650794
GO:BP GO:0030593 neutrophil chemotaxis 0.000493645957109506 103 51 5 0.0980392156862745 0.0485436893203883
GO:BP GO:0002831 regulation of response to biotic stimulus 0.000493645957109506 415 23 6 0.260869565217391 0.0144578313253012
GO:BP GO:0080111 DNA demethylation 0.000493645957109506 28 89 4 0.0449438202247191 0.142857142857143
GO:BP GO:0009605 response to external stimulus 0.000667789204742258 2944 43 19 0.441860465116279 0.00645380434782609
GO:BP GO:0032196 transposition 0.000699161671203892 31 89 4 0.0449438202247191 0.129032258064516
GO:BP GO:0001706 endoderm formation 0.000732517750537294 54 17 3 0.176470588235294 0.0555555555555556
GO:BP GO:0031347 regulation of defense response 0.00080289978681893 704 23 7 0.304347826086957 0.00994318181818182
GO:BP GO:0009164 nucleoside catabolic process 0.000852324755687417 33 89 4 0.0449438202247191 0.121212121212121
GO:BP GO:0002252 immune effector process 0.000889497656768678 1309 41 12 0.292682926829268 0.00916730328495034
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.000911703339329673 306 51 7 0.137254901960784 0.0228758169934641
GO:BP GO:0035510 DNA dealkylation 0.000911703339329673 34 89 4 0.0449438202247191 0.117647058823529
GO:BP GO:0006213 pyrimidine nucleoside metabolic process 0.00099072884085425 35 89 4 0.0449438202247191 0.114285714285714
GO:BP GO:1990266 neutrophil migration 0.00099072884085425 124 51 5 0.0980392156862745 0.0403225806451613
GO:BP GO:0071621 granulocyte chemotaxis 0.00104942371596762 126 51 5 0.0980392156862745 0.0396825396825397
GO:BP GO:0039694 viral RNA genome replication 0.0010739937654906 36 89 4 0.0449438202247191 0.111111111111111
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.00111720560370632 215 51 6 0.117647058823529 0.027906976744186
GO:BP GO:0070988 demethylation 0.00115274117396543 74 89 5 0.0561797752808989 0.0675675675675676
GO:BP GO:0009119 ribonucleoside metabolic process 0.00121110473768031 75 89 5 0.0561797752808989 0.0666666666666667
GO:BP GO:0002548 monocyte chemotaxis 0.0012316022687092 67 51 4 0.0784313725490196 0.0597014925373134
GO:BP GO:0034612 response to tumor necrosis factor 0.0012316022687092 331 51 7 0.137254901960784 0.0211480362537764
GO:BP GO:0072529 pyrimidine-containing compound catabolic process 0.0012316022687092 38 89 4 0.0449438202247191 0.105263157894737
GO:BP GO:0030595 leukocyte chemotaxis 0.00130386286297116 227 51 6 0.117647058823529 0.026431718061674
GO:BP GO:0001775 cell activation 0.00146465245034036 1495 45 13 0.288888888888889 0.00869565217391304
GO:BP GO:1901658 glycosyl compound catabolic process 0.0014938006924899 41 89 4 0.0449438202247191 0.0975609756097561
GO:BP GO:0071345 cellular response to cytokine stimulus 0.00165477055081988 1132 51 12 0.235294117647059 0.0106007067137809
GO:BP GO:0007492 endoderm development 0.00165477055081988 80 17 3 0.176470588235294 0.0375
GO:BP GO:0045069 regulation of viral genome replication 0.00173920516866251 84 89 5 0.0561797752808989 0.0595238095238095
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00182646882416466 3210 65 25 0.384615384615385 0.00778816199376947
GO:BP GO:0097530 granulocyte migration 0.00187035138215818 151 51 5 0.0980392156862745 0.033112582781457
GO:BP GO:0006968 cellular defense response 0.00252064020080621 53 30 3 0.1 0.0566037735849057
GO:BP GO:0002443 leukocyte mediated immunity 0.0026335234704394 877 40 9 0.225 0.0102622576966933
GO:BP GO:0034656 nucleobase-containing small molecule catabolic process 0.0026335234704394 49 89 4 0.0449438202247191 0.0816326530612245
GO:BP GO:0048525 negative regulation of viral process 0.0026335234704394 94 89 5 0.0561797752808989 0.0531914893617021
GO:BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 0.00264678207118805 93 18 3 0.166666666666667 0.032258064516129
GO:BP GO:0002250 adaptive immune response 0.002843189535473 689 40 8 0.2 0.011611030478955
GO:BP GO:0034097 response to cytokine 0.00297387604213217 1226 51 12 0.235294117647059 0.00978792822185971
GO:BP GO:0051928 positive regulation of calcium ion transport 0.00299601623341962 125 37 4 0.108108108108108 0.032
GO:BP GO:0071346 cellular response to interferon-gamma 0.00315927279090691 175 51 5 0.0980392156862745 0.0285714285714286
GO:BP GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 0.00326125861398186 50 95 4 0.0421052631578947 0.08
GO:BP GO:0045321 leukocyte activation 0.00369721853546302 1332 29 9 0.310344827586207 0.00675675675675676
GO:BP GO:0051924 regulation of calcium ion transport 0.00380547777543444 259 20 4 0.2 0.0154440154440154
GO:BP GO:0009116 nucleoside metabolic process 0.00409795269479009 107 89 5 0.0561797752808989 0.0467289719626168
GO:BP GO:0010959 regulation of metal ion transport 0.00417140713178634 268 20 4 0.2 0.0149253731343284
GO:BP GO:0001704 formation of primary germ layer 0.00422025234886746 123 17 3 0.176470588235294 0.024390243902439
GO:BP GO:0071674 mononuclear cell migration 0.00422025234886746 191 51 5 0.0980392156862745 0.0261780104712042
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.00468299838539456 309 51 6 0.117647058823529 0.0194174757281553
GO:BP GO:0034341 response to interferon-gamma 0.00468299838539456 196 51 5 0.0980392156862745 0.0255102040816327
GO:BP GO:0060326 cell chemotaxis 0.00472193545618369 310 51 6 0.117647058823529 0.0193548387096774
GO:BP GO:0006816 calcium ion transport 0.00481242026904247 436 37 6 0.162162162162162 0.0137614678899083
GO:BP GO:0002833 positive regulation of response to biotic stimulus 0.00520072539030821 250 23 4 0.173913043478261 0.016
GO:BP GO:0080134 regulation of response to stress 0.00526716295187564 1443 23 8 0.347826086956522 0.00554400554400554
GO:BP GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin 0.00526716295187564 24 95 3 0.0315789473684211 0.125
GO:BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 0.00578539036989905 133 18 3 0.166666666666667 0.0225563909774436
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.00595625674936507 329 51 6 0.117647058823529 0.0182370820668693
GO:BP GO:0042110 T cell activation 0.00595625674936507 489 13 4 0.307692307692308 0.0081799591002045
GO:BP GO:0002456 T cell mediated immunity 0.00631855023418626 98 61 4 0.0655737704918033 0.0408163265306122
GO:BP GO:0070555 response to interleukin-1 0.00635900888878171 215 51 5 0.0980392156862745 0.0232558139534884
GO:BP GO:0051050 positive regulation of transport 0.00658511729826965 923 20 6 0.3 0.00650054171180932
GO:BP GO:0097529 myeloid leukocyte migration 0.00691718865856453 221 51 5 0.0980392156862745 0.0226244343891403
GO:BP GO:0032103 positive regulation of response to external stimulus 0.00703260303619167 513 23 5 0.217391304347826 0.00974658869395711
GO:BP GO:0043270 positive regulation of ion transport 0.0077965116124143 694 37 7 0.189189189189189 0.0100864553314121
GO:BP GO:1901657 glycosyl compound metabolic process 0.00788177986832683 130 89 5 0.0561797752808989 0.0384615384615385
GO:BP GO:0019079 viral genome replication 0.00804131949523403 131 89 5 0.0561797752808989 0.0381679389312977
GO:BP GO:0046649 lymphocyte activation 0.00817387257971413 771 55 9 0.163636363636364 0.0116731517509728
GO:BP GO:0014065 phosphatidylinositol 3-kinase signaling 0.00863656585938338 161 18 3 0.166666666666667 0.0186335403726708
GO:BP GO:0050900 leukocyte migration 0.00899650261403222 511 51 7 0.137254901960784 0.0136986301369863
GO:BP GO:0030001 metal ion transport 0.00924139423004409 514 37 6 0.162162162162162 0.0116731517509728
GO:BP GO:0045088 regulation of innate immune response 0.00929900000941078 309 23 4 0.173913043478261 0.0129449838187702
GO:BP GO:0006950 response to stress 0.00952477093850644 4170 43 20 0.465116279069767 0.00479616306954436
GO:BP GO:0007369 gastrulation 0.0103334754375651 185 17 3 0.176470588235294 0.0162162162162162
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.0104759192760693 107 29 3 0.103448275862069 0.0280373831775701
GO:BP GO:0048015 phosphatidylinositol-mediated signaling 0.0138002305398171 197 18 3 0.166666666666667 0.0152284263959391
GO:BP GO:1903900 regulation of viral life cycle 0.0140421752849212 153 89 5 0.0561797752808989 0.0326797385620915
GO:BP GO:0048017 inositol lipid-mediated signaling 0.0143448432604541 201 18 3 0.166666666666667 0.0149253731343284
GO:BP GO:0031349 positive regulation of defense response 0.0148014604240725 362 23 4 0.173913043478261 0.0110497237569061
GO:BP GO:0043087 regulation of GTPase activity 0.0148014604240725 493 94 9 0.0957446808510638 0.0182555780933063
GO:BP GO:0002449 lymphocyte mediated immunity 0.0148014604240725 354 40 5 0.125 0.0141242937853107
GO:BP GO:0051209 release of sequestered calcium ion into cytosol 0.0152335634464987 123 30 3 0.1 0.024390243902439
GO:BP GO:0051283 negative regulation of sequestering of calcium ion 0.0152335634464987 124 30 3 0.1 0.0241935483870968
GO:BP GO:0051282 regulation of sequestering of calcium ion 0.0154892774672096 126 30 3 0.1 0.0238095238095238
GO:BP GO:0043547 positive regulation of GTPase activity 0.0154892774672096 413 71 7 0.0985915492957746 0.0169491525423729
GO:BP GO:0070266 necroptotic process 0.0159917229089177 46 83 3 0.036144578313253 0.0652173913043478
GO:BP GO:0051208 sequestering of calcium ion 0.0165656894464927 130 30 3 0.1 0.0230769230769231
GO:BP GO:0050896 response to stimulus 0.0170475383059345 9407 21 18 0.857142857142857 0.0019134686935261
GO:BP GO:0009451 RNA modification 0.0183325639250771 168 89 5 0.0561797752808989 0.0297619047619048
GO:BP GO:0051336 regulation of hydrolase activity 0.0184686633655485 1321 4 3 0.75 0.00227100681302044
GO:BP GO:0044728 DNA methylation or demethylation 0.0184686633655485 100 89 4 0.0449438202247191 0.04
GO:BP GO:0048584 positive regulation of response to stimulus 0.0184686633655485 2344 23 9 0.391304347826087 0.00383959044368601
GO:BP GO:0042116 macrophage activation 0.0201599972216546 110 83 4 0.0481927710843374 0.0363636363636364
GO:BP GO:0097553 calcium ion transmembrane import into cytosol 0.0212221611993659 145 30 3 0.1 0.0206896551724138
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0215105439372074 810 51 8 0.156862745098039 0.00987654320987654
GO:BP GO:0097300 programmed necrotic cell death 0.0231434556352169 54 83 3 0.036144578313253 0.0555555555555556
GO:BP GO:0003073 regulation of systemic arterial blood pressure 0.0232228959407984 101 95 4 0.0421052631578947 0.0396039603960396
GO:BP GO:0043408 regulation of MAPK cascade 0.0236231677701686 730 7 3 0.428571428571429 0.00410958904109589
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0264291232058715 539 62 7 0.112903225806452 0.012987012987013
GO:BP GO:0045089 positive regulation of innate immune response 0.0266095204921754 216 23 3 0.130434782608696 0.0138888888888889
GO:BP GO:0002274 myeloid leukocyte activation 0.0266095204921754 667 38 6 0.157894736842105 0.00899550224887556
GO:BP GO:0060402 calcium ion transport into cytosol 0.0268274454284177 165 30 3 0.1 0.0181818181818182
GO:BP GO:0050792 regulation of viral process 0.0269104156589574 192 54 4 0.0740740740740741 0.0208333333333333
GO:BP GO:0016032 viral process 0.0269104156589574 942 12 4 0.333333333333333 0.00424628450106157
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.0269104156589574 1037 62 10 0.161290322580645 0.00964320154291225
GO:BP GO:0001906 cell killing 0.0274487148949541 175 29 3 0.103448275862069 0.0171428571428571
GO:BP GO:0051046 regulation of secretion 0.0277465735360224 647 28 5 0.178571428571429 0.00772797527047913
GO:BP GO:1901136 carbohydrate derivative catabolic process 0.0277465735360224 196 54 4 0.0740740740740741 0.0204081632653061
GO:BP GO:0009967 positive regulation of signal transduction 0.0277465735360224 1598 23 7 0.304347826086957 0.00438047559449312
GO:BP GO:0042267 natural killer cell mediated cytotoxicity 0.0277465735360224 62 82 3 0.0365853658536585 0.0483870967741935
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.0282527268715474 241 45 4 0.0888888888888889 0.016597510373444
GO:BP GO:0006304 DNA modification 0.0285853234278354 122 89 4 0.0449438202247191 0.0327868852459016
GO:BP GO:0043085 positive regulation of catalytic activity 0.0286908298788425 1418 71 13 0.183098591549296 0.00916784203102962
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 0.0286908298788425 203 54 4 0.0740740740740741 0.0197044334975369
GO:BP GO:0044093 positive regulation of molecular function 0.0286908298788425 1771 71 15 0.211267605633803 0.00846979107848673
GO:BP GO:0002228 natural killer cell mediated immunity 0.0288322300193252 65 82 3 0.0365853658536585 0.0461538461538462
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.028877332024955 1001 12 4 0.333333333333333 0.003996003996004
GO:BP GO:0006935 chemotaxis 0.028877332024955 653 84 9 0.107142857142857 0.0137825421133231
GO:BP GO:0042330 taxis 0.0290863569609708 656 84 9 0.107142857142857 0.013719512195122
GO:BP GO:0000165 MAPK cascade 0.029949446940109 935 39 7 0.179487179487179 0.00748663101604278
GO:BP GO:0060401 cytosolic calcium ion transport 0.0303209116756374 186 30 3 0.1 0.0161290322580645
GO:BP GO:0010647 positive regulation of cell communication 0.030703954591762 1777 39 10 0.256410256410256 0.0056274620146314
GO:BP GO:0023056 positive regulation of signaling 0.0311059184715214 1782 39 10 0.256410256410256 0.00561167227833894
GO:BP GO:0070265 necrotic cell death 0.0312534073411027 68 83 3 0.036144578313253 0.0441176470588235
GO:BP GO:1901214 regulation of neuron death 0.0312534073411027 323 18 3 0.166666666666667 0.00928792569659443
GO:BP GO:0036230 granulocyte activation 0.0316343816498938 504 38 5 0.131578947368421 0.00992063492063492
GO:BP GO:0019058 viral life cycle 0.0321694134898267 353 54 5 0.0925925925925926 0.0141643059490085
GO:BP GO:0070588 calcium ion transmembrane transport 0.0323455427333618 320 37 4 0.108108108108108 0.0125
GO:BP GO:0065009 regulation of molecular function 0.0364893005965866 3221 71 22 0.309859154929577 0.00683017696367588
GO:BP GO:0044344 cellular response to fibroblast growth factor stimulus 0.0373818775230744 147 43 3 0.0697674418604651 0.0204081632653061
GO:BP GO:0070997 neuron death 0.0378822945030057 365 18 3 0.166666666666667 0.00821917808219178
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.0379431005732412 284 45 4 0.0888888888888889 0.0140845070422535
GO:BP GO:0071774 response to fibroblast growth factor 0.0395173722043365 153 43 3 0.0697674418604651 0.0196078431372549
GO:BP GO:0051651 maintenance of location in cell 0.0404695356471613 223 30 3 0.1 0.0134529147982063
GO:BP GO:0030101 natural killer cell activation 0.0435162529872154 84 82 3 0.0365853658536585 0.0357142857142857
GO:BP GO:0006874 cellular calcium ion homeostasis 0.0440081089992946 460 30 4 0.133333333333333 0.00869565217391304
GO:BP GO:0055074 calcium ion homeostasis 0.0461496236888818 472 30 4 0.133333333333333 0.00847457627118644
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0463085766216698 1151 7 3 0.428571428571429 0.00260642919200695
GO:BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 0.0463085766216698 269 52 4 0.0769230769230769 0.0148698884758364
GO:BP GO:0009966 regulation of signal transduction 0.047274826662339 3165 62 19 0.306451612903226 0.00600315955766193
GO:BP GO:0071310 cellular response to organic substance 0.047274826662339 2776 51 15 0.294117647058824 0.00540345821325648
GO:BP GO:0030217 T cell differentiation 0.0479646246360493 260 55 4 0.0727272727272727 0.0153846153846154
GO:BP GO:0006909 phagocytosis 0.0492412420651693 387 20 3 0.15 0.00775193798449612
GO:BP GO:0051223 regulation of protein transport 0.0495721893324259 586 72 7 0.0972222222222222 0.0119453924914676
GO:BP GO:0006417 regulation of translation 0.0495721893324259 462 32 4 0.125 0.00865800865800866
GO:CC GO:0009986 cell surface 0.00366531582133848 899 40 10 0.25 0.0111234705228031
GO:CC GO:0000932 P-body 0.00484243388348217 91 89 5 0.0561797752808989 0.0549450549450549
GO:CC GO:0005887 integral component of plasma membrane 0.00484243388348217 1645 84 19 0.226190476190476 0.0115501519756839
GO:CC GO:0044853 plasma membrane raft 0.00484243388348217 116 37 4 0.108108108108108 0.0344827586206897
GO:CC GO:0009897 external side of plasma membrane 0.00484243388348217 408 82 9 0.109756097560976 0.0220588235294118
GO:CC GO:0031226 intrinsic component of plasma membrane 0.00761923593429819 1726 84 19 0.226190476190476 0.0110081112398609
GO:CC GO:0005576 extracellular region 0.0130095950408535 4567 10 8 0.8 0.00175169695642654
GO:CC GO:0005886 plasma membrane 0.0423318069763564 5681 86 39 0.453488372093023 0.0068649885583524
GO:CC GO:0098552 side of membrane 0.0423318069763564 619 82 9 0.109756097560976 0.0145395799676898
GO:CC GO:0098802 plasma membrane signaling receptor complex 0.0437389980248163 300 17 3 0.176470588235294 0.01
GO:CC GO:0098590 plasma membrane region 0.0468284416761212 1240 38 8 0.210526315789474 0.00645161290322581
GO:CC GO:0098797 plasma membrane protein complex 0.0482475363897312 694 28 5 0.178571428571429 0.00720461095100865
GO:CC GO:0030667 secretory granule membrane 0.0482475363897312 303 38 4 0.105263157894737 0.0132013201320132
GO:CC GO:0045121 membrane raft 0.0495244230467731 335 18 3 0.166666666666667 0.00895522388059702
GO:CC GO:0071944 cell periphery 0.0495244230467731 6169 88 41 0.465909090909091 0.00664613389528287
GO:CC GO:0098857 membrane microdomain 0.0495244230467731 335 18 3 0.166666666666667 0.00895522388059702
GO:CC GO:0036464 cytoplasmic ribonucleoprotein granule 0.0495732931370644 237 54 4 0.0740740740740741 0.0168776371308017
GO:MF GO:0047844 deoxycytidine deaminase activity 1.21989248200956e-05 8 89 4 0.0449438202247191 0.5
GO:MF GO:0004126 cytidine deaminase activity 3.15631850182844e-05 12 89 4 0.0449438202247191 0.333333333333333
GO:MF GO:0008009 chemokine activity 0.000583739262172687 49 51 4 0.0784313725490196 0.0816326530612245
GO:MF GO:0048020 CCR chemokine receptor binding 0.000583739262172687 48 51 4 0.0784313725490196 0.0833333333333333
GO:MF GO:0019239 deaminase activity 0.000820316322900408 32 89 4 0.0449438202247191 0.125
GO:MF GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines 0.00103378685191837 35 89 4 0.0449438202247191 0.114285714285714
GO:MF GO:0015026 coreceptor activity 0.00192914613292212 47 30 3 0.1 0.0638297872340425
GO:MF GO:0005515 protein binding 0.00385319875021779 14767 68 65 0.955882352941177 0.00440170650775378
GO:MF GO:0060089 molecular transducer activity 0.0069352364417253 1458 86 17 0.197674418604651 0.0116598079561043
GO:MF GO:0038023 signaling receptor activity 0.0069352364417253 1458 86 17 0.197674418604651 0.0116598079561043
GO:MF GO:0005125 cytokine activity 0.00855925583315207 235 51 5 0.0980392156862745 0.0212765957446809
GO:MF GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 0.00855925583315207 132 89 5 0.0561797752808989 0.0378787878787879
GO:MF GO:0005102 signaling receptor binding 0.0104348225257967 1672 18 7 0.388888888888889 0.0041866028708134
GO:MF GO:0042802 identical protein binding 0.0344547526411938 2067 4 3 0.75 0.00145137880986938
GO:MF GO:0098772 molecular function regulator 0.0463559545138066 2363 4 3 0.75 0.00126957257723233
GO:MF GO:0044877 protein-containing complex binding 0.0490463619567322 1287 43 8 0.186046511627907 0.00621600621600622
KEGG KEGG:05340 Primary immunodeficiency 0.0169818012494796 37 37 3 0.0810810810810811 0.0810810810810811
KEGG KEGG:04061 Viral protein interaction with cytokine and cytokine receptor 0.0169818012494796 98 51 5 0.0980392156862745 0.0510204081632653
KEGG KEGG:04514 Cell adhesion molecules 0.041865709673683 146 17 3 0.176470588235294 0.0205479452054795
KEGG KEGG:04650 Natural killer cell mediated cytotoxicity 0.041865709673683 123 21 3 0.142857142857143 0.024390243902439
MIRNA MIRNA:hsa-miR-4726-5p hsa-miR-4726-5p 0.00897384850357081 119 7 3 0.428571428571429 0.0252100840336134
MIRNA MIRNA:hsa-miR-4640-5p hsa-miR-4640-5p 0.00897384850357081 120 7 3 0.428571428571429 0.025
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 5.38329179639087e-06 181 29 8 0.275862068965517 0.0441988950276243
REAC REAC:R-HSA-168256 Immune System 0.00532401718532421 2139 40 19 0.475 0.00888265544647031
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.00532401718532421 800 21 8 0.380952380952381 0.01
WP WP:WP4754 IL-18 signaling pathway 0.0110106550465065 279 6 3 0.5 0.010752688172043

pTNI20 transcription factor target enrichment of top program genes

TF enrichment of pTNI20
TFs corrosponding to activation of pTNI20. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.