pEpiTd11 program activity among Epithelial cells

Activation of pEpiTd11
pEpiTd11 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd11 by different cell subtypes
pEpiTd11 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd11 top program genes

Top genes of pEpiTd11 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd11 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd11
pEpiTd11 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:1199 Oligosaccharyltransferase complex (Stt3A variant) 2.70583387702964e-05 6 52 4 0.0769230769230769 0.666666666666667
CORUM CORUM:6131 SELK multiprotein complex 0.000181510978125319 10 52 4 0.0769230769230769 0.4
CORUM CORUM:1200 Oligosaccharyltransferase complex (Stt3B variant) 0.000543462665602292 7 37 3 0.0810810810810811 0.428571428571429
CORUM CORUM:6859 HRD1 complex 0.00109302781056516 13 26 3 0.115384615384615 0.230769230769231
GO:BP GO:0016126 sterol biosynthetic process 3.15022180330927e-22 80 89 18 0.202247191011236 0.225
GO:BP GO:1902653 secondary alcohol biosynthetic process 1.73346645298439e-21 74 89 17 0.191011235955056 0.22972972972973
GO:BP GO:0006695 cholesterol biosynthetic process 1.73346645298439e-21 74 89 17 0.191011235955056 0.22972972972973
GO:BP GO:0016125 sterol metabolic process 1.44433665908428e-19 171 89 20 0.224719101123595 0.116959064327485
GO:BP GO:0008203 cholesterol metabolic process 5.02823086075869e-19 154 89 19 0.213483146067416 0.123376623376623
GO:BP GO:1902652 secondary alcohol metabolic process 1.34387823264273e-18 164 89 19 0.213483146067416 0.115853658536585
GO:BP GO:0006694 steroid biosynthetic process 1.34387823264273e-18 196 89 20 0.224719101123595 0.102040816326531
GO:BP GO:0046165 alcohol biosynthetic process 1.78068593775212e-17 158 89 18 0.202247191011236 0.113924050632911
GO:BP GO:0008202 steroid metabolic process 2.1508995550201e-16 342 89 22 0.247191011235955 0.064327485380117
GO:BP GO:1901617 organic hydroxy compound biosynthetic process 3.72586299841039e-15 254 89 19 0.213483146067416 0.0748031496062992
GO:BP GO:0006066 alcohol metabolic process 2.97173288663079e-14 382 89 21 0.235955056179775 0.0549738219895288
GO:BP GO:0044283 small molecule biosynthetic process 5.80215100031624e-14 704 89 26 0.292134831460674 0.0369318181818182
GO:BP GO:0045540 regulation of cholesterol biosynthetic process 1.22264458306238e-13 50 89 11 0.123595505617978 0.22
GO:BP GO:0106118 regulation of sterol biosynthetic process 1.22264458306238e-13 50 89 11 0.123595505617978 0.22
GO:BP GO:0008610 lipid biosynthetic process 1.51681508373827e-12 740 89 25 0.280898876404494 0.0337837837837838
GO:BP GO:0090181 regulation of cholesterol metabolic process 2.01478317136113e-12 64 89 11 0.123595505617978 0.171875
GO:BP GO:1901615 organic hydroxy compound metabolic process 5.19489695578715e-12 571 89 22 0.247191011235955 0.0385288966725044
GO:BP GO:0050810 regulation of steroid biosynthetic process 6.52783276384663e-12 97 89 12 0.134831460674157 0.123711340206186
GO:BP GO:0034975 protein folding in endoplasmic reticulum 1.5951332725843e-11 11 16 5 0.3125 0.454545454545455
GO:BP GO:1902930 regulation of alcohol biosynthetic process 1.5951332725843e-11 78 89 11 0.123595505617978 0.141025641025641
GO:BP GO:0034976 response to endoplasmic reticulum stress 4.50639248633712e-11 298 21 10 0.476190476190476 0.0335570469798658
GO:BP GO:0006629 lipid metabolic process 1.81331149423281e-10 1457 108 34 0.314814814814815 0.0233356211393274
GO:BP GO:0019218 regulation of steroid metabolic process 1.81331149423281e-10 130 89 12 0.134831460674157 0.0923076923076923
GO:BP GO:0046890 regulation of lipid biosynthetic process 7.07764926431039e-10 215 115 15 0.130434782608696 0.0697674418604651
GO:BP GO:0055114 obsolete oxidation-reduction process 8.2722865564029e-09 745 91 21 0.230769230769231 0.0281879194630872
GO:BP GO:0006986 response to unfolded protein 8.2722865564029e-09 184 9 6 0.666666666666667 0.0326086956521739
GO:BP GO:0006457 protein folding 8.2722865564029e-09 225 21 8 0.380952380952381 0.0355555555555556
GO:BP GO:0019216 regulation of lipid metabolic process 1.36637946993619e-08 419 115 18 0.156521739130435 0.0429594272076372
GO:BP GO:0035966 response to topologically incorrect protein 1.38657395872628e-08 205 9 6 0.666666666666667 0.0292682926829268
GO:BP GO:0044281 small molecule metabolic process 1.54681977216398e-08 1921 89 32 0.359550561797753 0.0166579906298803
GO:BP GO:0006984 ER-nucleus signaling pathway 8.66124792291107e-08 53 17 5 0.294117647058824 0.0943396226415094
GO:BP GO:0030968 endoplasmic reticulum unfolded protein response 1.581163801327e-07 128 9 5 0.555555555555556 0.0390625
GO:BP GO:0034620 cellular response to unfolded protein 3.3013766303268e-07 149 9 5 0.555555555555556 0.0335570469798658
GO:BP GO:0035967 cellular response to topologically incorrect protein 5.86377041515061e-07 168 9 5 0.555555555555556 0.0297619047619048
GO:BP GO:0006720 isoprenoid metabolic process 6.65676854688833e-07 144 103 10 0.0970873786407767 0.0694444444444444
GO:BP GO:0036500 ATF6-mediated unfolded protein response 7.11961171529409e-07 10 9 3 0.333333333333333 0.3
GO:BP GO:0044255 cellular lipid metabolic process 8.24096579563607e-07 1075 115 25 0.217391304347826 0.0232558139534884
GO:BP GO:0045338 farnesyl diphosphate metabolic process 1.53888567166813e-06 5 25 3 0.12 0.6
GO:BP GO:0033489 cholesterol biosynthetic process via desmosterol 3.13822554714845e-06 4 43 3 0.0697674418604651 0.75
GO:BP GO:0033490 cholesterol biosynthetic process via lathosterol 3.13822554714845e-06 4 43 3 0.0697674418604651 0.75
GO:BP GO:0008299 isoprenoid biosynthetic process 8.20576496419441e-06 29 77 5 0.0649350649350649 0.172413793103448
GO:BP GO:0045454 cell redox homeostasis 1.02336311080926e-05 58 40 5 0.125 0.0862068965517241
GO:BP GO:0042221 response to chemical 2.51592050903852e-05 4781 11 11 1 0.00230077389667434
GO:BP GO:1905897 regulation of response to endoplasmic reticulum stress 3.02900097792575e-05 84 104 7 0.0673076923076923 0.0833333333333333
GO:BP GO:0070972 protein localization to endoplasmic reticulum 4.1967331281653e-05 146 22 5 0.227272727272727 0.0342465753424658
GO:BP GO:0062012 regulation of small molecule metabolic process 4.59411143984413e-05 447 43 9 0.209302325581395 0.0201342281879195
GO:BP GO:0006487 protein N-linked glycosylation 4.84009980543858e-05 76 78 6 0.0769230769230769 0.0789473684210526
GO:BP GO:0018279 protein N-linked glycosylation via asparagine 8.22744751605858e-05 30 52 4 0.0769230769230769 0.133333333333333
GO:BP GO:0018196 peptidyl-asparagine modification 9.23395072996266e-05 31 52 4 0.0769230769230769 0.129032258064516
GO:BP GO:0046394 carboxylic acid biosynthetic process 9.42874163367497e-05 330 80 10 0.125 0.0303030303030303
GO:BP GO:0016053 organic acid biosynthetic process 0.000114552969735953 338 80 10 0.125 0.029585798816568
GO:BP GO:0010033 response to organic substance 0.000119178545746879 3412 10 9 0.9 0.00263774912075029
GO:BP GO:0043312 neutrophil degranulation 0.000133965096652482 482 86 12 0.13953488372093 0.024896265560166
GO:BP GO:0002283 neutrophil activation involved in immune response 0.000140152177802605 485 86 12 0.13953488372093 0.0247422680412371
GO:BP GO:0002446 neutrophil mediated immunity 0.000176814042164647 497 86 12 0.13953488372093 0.0241448692152917
GO:BP GO:0036498 IRE1-mediated unfolded protein response 0.000176981186082073 67 9 3 0.333333333333333 0.0447761194029851
GO:BP GO:0042119 neutrophil activation 0.000176981186082073 498 86 12 0.13953488372093 0.0240963855421687
GO:BP GO:0036230 granulocyte activation 0.000193428711384669 504 86 12 0.13953488372093 0.0238095238095238
GO:BP GO:0071704 organic substance metabolic process 0.000197675188493878 11326 48 44 0.916666666666667 0.00388486667843899
GO:BP GO:0033554 cellular response to stress 0.000254311596343602 2111 21 11 0.523809523809524 0.00521080056845097
GO:BP GO:0065008 regulation of biological quality 0.000254311596343602 4131 67 32 0.477611940298507 0.00774630839990317
GO:BP GO:1903573 negative regulation of response to endoplasmic reticulum stress 0.000259189623380331 46 104 5 0.0480769230769231 0.108695652173913
GO:BP GO:0006721 terpenoid metabolic process 0.000259189623380331 123 103 7 0.0679611650485437 0.0569105691056911
GO:BP GO:0043299 leukocyte degranulation 0.000321108154676795 535 86 12 0.13953488372093 0.0224299065420561
GO:BP GO:0045047 protein targeting to ER 0.000373702933619165 113 22 4 0.181818181818182 0.0353982300884956
GO:BP GO:0006633 fatty acid biosynthetic process 0.000383346044049373 170 80 7 0.0875 0.0411764705882353
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.000383346044049373 547 86 12 0.13953488372093 0.0219378427787934
GO:BP GO:0070887 cellular response to chemical stimulus 0.000395503539327998 3393 9 8 0.888888888888889 0.00235779546124374
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 0.000395503539327998 117 22 4 0.181818181818182 0.0341880341880342
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.000395503539327998 551 86 12 0.13953488372093 0.0217785843920145
GO:BP GO:0051235 maintenance of location 0.000395503539327998 337 17 5 0.294117647058824 0.0148367952522255
GO:BP GO:0031647 regulation of protein stability 0.000438471906352672 300 66 8 0.121212121212121 0.0266666666666667
GO:BP GO:0009058 biosynthetic process 0.000540168634952047 6340 96 54 0.5625 0.00851735015772871
GO:BP GO:0016114 terpenoid biosynthetic process 0.000560060253189407 15 62 3 0.0483870967741935 0.2
GO:BP GO:0006644 phospholipid metabolic process 0.000569437767361515 427 115 12 0.104347826086957 0.0281030444964871
GO:BP GO:0097006 regulation of plasma lipoprotein particle levels 0.000582177328215901 107 55 5 0.0909090909090909 0.0467289719626168
GO:BP GO:0045055 regulated exocytosis 0.000584393435090185 785 86 14 0.162790697674419 0.0178343949044586
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.000611054267859559 1145 85 17 0.2 0.0148471615720524
GO:BP GO:1903894 regulation of IRE1-mediated unfolded protein response 0.000634547175275258 15 66 3 0.0454545454545455 0.2
GO:BP GO:0008152 metabolic process 0.000719839238363982 11827 48 44 0.916666666666667 0.00372030100617232
GO:BP GO:1901576 organic substance biosynthetic process 0.000744270670316022 6248 96 53 0.552083333333333 0.00848271446862996
GO:BP GO:0046903 secretion 0.000943794401927463 1501 89 20 0.224719101123595 0.0133244503664224
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 0.000964363280004653 124 27 4 0.148148148148148 0.032258064516129
GO:BP GO:1900222 negative regulation of amyloid-beta clearance 0.00116261277836191 11 115 3 0.0260869565217391 0.272727272727273
GO:BP GO:0006790 sulfur compound metabolic process 0.0011920812067493 386 78 9 0.115384615384615 0.0233160621761658
GO:BP GO:0061077 chaperone-mediated protein folding 0.00132686793889925 61 21 3 0.142857142857143 0.0491803278688525
GO:BP GO:0051651 maintenance of location in cell 0.00132981943341318 223 17 4 0.235294117647059 0.0179372197309417
GO:BP GO:0140352 export from cell 0.00134369307001734 1418 89 19 0.213483146067416 0.0133991537376587
GO:BP GO:0080135 regulation of cellular response to stress 0.00137045147676347 725 18 6 0.333333333333333 0.00827586206896552
GO:BP GO:0006631 fatty acid metabolic process 0.00144499945112423 404 115 11 0.0956521739130435 0.0272277227722772
GO:BP GO:0071310 cellular response to organic substance 0.00144499945112423 2776 9 7 0.777777777777778 0.00252161383285303
GO:BP GO:0014074 response to purine-containing compound 0.00163831023874952 152 26 4 0.153846153846154 0.0263157894736842
GO:BP GO:0072330 monocarboxylic acid biosynthetic process 0.00165211131074121 226 80 7 0.0875 0.0309734513274336
GO:BP GO:0002274 myeloid leukocyte activation 0.00184606368691273 667 86 12 0.13953488372093 0.0179910044977511
GO:BP GO:0031589 cell-substrate adhesion 0.00199911235385527 367 5 3 0.6 0.00817438692098093
GO:BP GO:0019725 cellular homeostasis 0.00199911235385527 981 21 7 0.333333333333333 0.00713557594291539
GO:BP GO:0009100 glycoprotein metabolic process 0.00204549617482807 424 78 9 0.115384615384615 0.0212264150943396
GO:BP GO:0006637 acyl-CoA metabolic process 0.00204549617482807 105 77 5 0.0649350649350649 0.0476190476190476
GO:BP GO:0035383 thioester metabolic process 0.00204549617482807 105 77 5 0.0649350649350649 0.0476190476190476
GO:BP GO:0006887 exocytosis 0.00204549617482807 904 86 14 0.162790697674419 0.0154867256637168
GO:BP GO:0120178 steroid hormone biosynthetic process 0.00209912533539422 50 85 4 0.0470588235294118 0.08
GO:BP GO:0032940 secretion by cell 0.0022579311288379 1364 89 18 0.202247191011236 0.0131964809384164
GO:BP GO:0006486 protein glycosylation 0.00234374966035442 251 78 7 0.0897435897435897 0.0278884462151394
GO:BP GO:0043413 macromolecule glycosylation 0.00234374966035442 251 78 7 0.0897435897435897 0.0278884462151394
GO:BP GO:0042592 homeostatic process 0.00234909799143152 1981 58 17 0.293103448275862 0.00858152448258455
GO:BP GO:0018126 protein hydroxylation 0.00238221064803286 28 60 3 0.05 0.107142857142857
GO:BP GO:0046949 fatty-acyl-CoA biosynthetic process 0.00248076477541853 31 55 3 0.0545454545454545 0.0967741935483871
GO:BP GO:0070085 glycosylation 0.00296509019119874 264 78 7 0.0897435897435897 0.0265151515151515
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00296509019119874 717 86 12 0.13953488372093 0.0167364016736402
GO:BP GO:0032787 monocarboxylic acid metabolic process 0.00298715814607494 658 80 11 0.1375 0.0167173252279635
GO:BP GO:0002263 cell activation involved in immune response 0.00305878294837549 721 86 12 0.13953488372093 0.0166435506241331
GO:BP GO:0044238 primary metabolic process 0.0034922737300441 10584 45 38 0.844444444444444 0.00359032501889645
GO:BP GO:0071705 nitrogen compound transport 0.00354221165744075 2322 22 10 0.454545454545455 0.00430663221360896
GO:BP GO:0015031 protein transport 0.00384198754384788 1929 26 10 0.384615384615385 0.00518403317781234
GO:BP GO:0051641 cellular localization 0.00384198754384788 3541 74 28 0.378378378378378 0.00790737079920926
GO:BP GO:0008654 phospholipid biosynthetic process 0.00406430687992988 274 80 7 0.0875 0.0255474452554745
GO:BP GO:0034613 cellular protein localization 0.00420357775555854 2014 17 8 0.470588235294118 0.00397219463753724
GO:BP GO:0051649 establishment of localization in cell 0.00420357775555854 2813 74 24 0.324324324324324 0.00853181656594383
GO:BP GO:1900221 regulation of amyloid-beta clearance 0.00422249831166908 19 115 3 0.0260869565217391 0.157894736842105
GO:BP GO:0070727 cellular macromolecule localization 0.00425665407076241 2024 17 8 0.470588235294118 0.00395256916996047
GO:BP GO:0015833 peptide transport 0.00429373325379253 1971 26 10 0.384615384615385 0.00507356671740233
GO:BP GO:0042886 amide transport 0.00488090837376886 2007 26 10 0.384615384615385 0.0049825610363727
GO:BP GO:0035337 fatty-acyl-CoA metabolic process 0.00496766273794495 42 55 3 0.0545454545454545 0.0714285714285714
GO:BP GO:0010941 regulation of cell death 0.00504325352228977 1720 20 8 0.4 0.00465116279069767
GO:BP GO:0045184 establishment of protein localization 0.0052830524182455 2035 26 10 0.384615384615385 0.00491400491400491
GO:BP GO:0006636 unsaturated fatty acid biosynthetic process 0.00528764090731999 51 115 4 0.0347826086956522 0.0784313725490196
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.00529917479905483 222 27 4 0.148148148148148 0.018018018018018
GO:BP GO:0033875 ribonucleoside bisphosphate metabolic process 0.00547678057051776 141 77 5 0.0649350649350649 0.0354609929078014
GO:BP GO:0033865 nucleoside bisphosphate metabolic process 0.00547678057051776 141 77 5 0.0649350649350649 0.0354609929078014
GO:BP GO:0018208 peptidyl-proline modification 0.00547678057051776 61 40 3 0.075 0.0491803278688525
GO:BP GO:0006898 receptor-mediated endocytosis 0.00547678057051776 333 8 3 0.375 0.00900900900900901
GO:BP GO:0034032 purine nucleoside bisphosphate metabolic process 0.00547678057051776 141 77 5 0.0649350649350649 0.0354609929078014
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.00554546951490897 1853 86 20 0.232558139534884 0.0107933081489477
GO:BP GO:0042446 hormone biosynthetic process 0.00554836522990025 71 85 4 0.0470588235294118 0.0563380281690141
GO:BP GO:0006886 intracellular protein transport 0.00572623260821635 1186 22 7 0.318181818181818 0.00590219224283305
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.00628369201672881 686 60 9 0.15 0.0131195335276968
GO:BP GO:0051094 positive regulation of developmental process 0.00630523902033721 1341 3 3 1 0.00223713646532438
GO:BP GO:0002090 regulation of receptor internalization 0.00672021512314444 57 47 3 0.0638297872340425 0.0526315789473684
GO:BP GO:0006612 protein targeting to membrane 0.0070622807510535 204 14 3 0.214285714285714 0.0147058823529412
GO:BP GO:0051716 cellular response to stimulus 0.00737558808918486 7781 9 9 1 0.00115666366790901
GO:BP GO:0019752 carboxylic acid metabolic process 0.00758672620724428 1024 80 13 0.1625 0.0126953125
GO:BP GO:0033036 macromolecule localization 0.00802107376414574 3218 22 11 0.5 0.00341827221876942
GO:BP GO:0071616 acyl-CoA biosynthetic process 0.00834485025635646 54 55 3 0.0545454545454545 0.0555555555555556
GO:BP GO:0035384 thioester biosynthetic process 0.00834485025635646 54 55 3 0.0545454545454545 0.0555555555555556
GO:BP GO:0018215 protein phosphopantetheinylation 0.00834762008142967 344 21 4 0.19047619047619 0.0116279069767442
GO:BP GO:0046907 intracellular transport 0.00916815770479692 1767 17 7 0.411764705882353 0.00396151669496321
GO:BP GO:0016192 vesicle-mediated transport 0.00924611325639992 2180 56 16 0.285714285714286 0.0073394495412844
GO:BP GO:0002443 leukocyte mediated immunity 0.00928155724199164 877 120 15 0.125 0.0171037628278221
GO:BP GO:0043436 oxoacid metabolic process 0.00929445302314178 1057 80 13 0.1625 0.0122989593188269
GO:BP GO:0009101 glycoprotein biosynthetic process 0.00968817900342315 347 78 7 0.0897435897435897 0.0201729106628242
GO:BP GO:0050896 response to stimulus 0.00969572156544572 9407 11 11 1 0.00116934197937706
GO:BP GO:0071702 organic substance transport 0.0097526439590474 2766 22 10 0.454545454545455 0.00361532899493854
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.00976650559675363 4439 96 38 0.395833333333333 0.0085604865960802
GO:BP GO:0008104 protein localization 0.00976650559675363 2770 22 10 0.454545454545455 0.0036101083032491
GO:BP GO:0006950 response to stress 0.0099443546050056 4170 9 7 0.777777777777778 0.00167865707434053
GO:BP GO:0009967 positive regulation of signal transduction 0.0099443546050056 1598 6 4 0.666666666666667 0.00250312891113892
GO:BP GO:0034381 plasma lipoprotein particle clearance 0.0100074999693029 70 47 3 0.0638297872340425 0.0428571428571429
GO:BP GO:1901570 fatty acid derivative biosynthetic process 0.0105629797328243 61 55 3 0.0545454545454545 0.0491803278688525
GO:BP GO:0006082 organic acid metabolic process 0.0111698341512449 1090 80 13 0.1625 0.0119266055045872
GO:BP GO:0042981 regulation of apoptotic process 0.01132547168498 1549 20 7 0.35 0.00451904454486766
GO:BP GO:0046683 response to organophosphorus 0.0113961193270254 137 26 3 0.115384615384615 0.0218978102189781
GO:BP GO:0090150 establishment of protein localization to membrane 0.0113961193270254 351 59 6 0.101694915254237 0.0170940170940171
GO:BP GO:0016032 viral process 0.0115950659882631 942 16 5 0.3125 0.00530785562632696
GO:BP GO:0051179 localization 0.011740509547006 6901 22 16 0.727272727272727 0.00231850456455586
GO:BP GO:0033365 protein localization to organelle 0.0118848156633393 1017 22 6 0.272727272727273 0.00589970501474926
GO:BP GO:0006820 anion transport 0.0118848156633393 2889 22 10 0.454545454545455 0.00346140533056421
GO:BP GO:0043067 regulation of programmed cell death 0.0119347691275932 1582 20 7 0.35 0.00442477876106195
GO:BP GO:0071407 cellular response to organic cyclic compound 0.0120519018321828 587 25 5 0.2 0.00851788756388416
GO:BP GO:0042632 cholesterol homeostasis 0.0125357212527014 99 38 3 0.0789473684210526 0.0303030303030303
GO:BP GO:0033866 nucleoside bisphosphate biosynthetic process 0.0125357212527014 68 55 3 0.0545454545454545 0.0441176470588235
GO:BP GO:0034030 ribonucleoside bisphosphate biosynthetic process 0.0125357212527014 68 55 3 0.0545454545454545 0.0441176470588235
GO:BP GO:0034033 purine nucleoside bisphosphate biosynthetic process 0.0125357212527014 68 55 3 0.0545454545454545 0.0441176470588235
GO:BP GO:0010647 positive regulation of cell communication 0.012579108817825 1777 6 4 0.666666666666667 0.00225098480585256
GO:BP GO:0023056 positive regulation of signaling 0.012661681841112 1782 6 4 0.666666666666667 0.00224466891133558
GO:BP GO:0044237 cellular metabolic process 0.0126785830493591 10871 38 32 0.842105263157895 0.00294361144328949
GO:BP GO:0055092 sterol homeostasis 0.0126785830493591 100 38 3 0.0789473684210526 0.03
GO:BP GO:0090407 organophosphate biosynthetic process 0.0132073662433257 598 80 9 0.1125 0.0150501672240803
GO:BP GO:1990266 neutrophil migration 0.0136106029547191 124 32 3 0.09375 0.0241935483870968
GO:BP GO:0072657 protein localization to membrane 0.0136106029547191 665 59 8 0.135593220338983 0.0120300751879699
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0136106029547191 1001 16 5 0.3125 0.004995004995005
GO:BP GO:0007165 signal transduction 0.0136106029547191 6309 9 8 0.888888888888889 0.00126802979870027
GO:BP GO:0044272 sulfur compound biosynthetic process 0.0143426731871362 193 78 5 0.0641025641025641 0.0259067357512953
GO:BP GO:0042493 response to drug 0.0144023795836473 396 11 3 0.272727272727273 0.00757575757575758
GO:BP GO:0052372 modulation by symbiont of entry into host 0.0148199870938856 50 83 3 0.036144578313253 0.06
GO:BP GO:0043687 post-translational protein modification 0.0154732461300298 362 86 7 0.0813953488372093 0.0193370165745856
GO:BP GO:0006811 ion transport 0.0158381593573001 3661 22 11 0.5 0.00300464354001639
GO:BP GO:0097242 amyloid-beta clearance 0.0162393331671317 38 115 3 0.0260869565217391 0.0789473684210526
GO:BP GO:0006605 protein targeting 0.0162393331671317 441 22 4 0.181818181818182 0.0090702947845805
GO:BP GO:0050900 leukocyte migration 0.0168642582302439 511 32 5 0.15625 0.00978473581213307
GO:BP GO:1901568 fatty acid derivative metabolic process 0.0171006062951823 81 55 3 0.0545454545454545 0.037037037037037
GO:BP GO:0008219 cell death 0.017321183552444 2292 20 8 0.4 0.00349040139616056
GO:BP GO:0032091 negative regulation of protein binding 0.0175208209664369 97 47 3 0.0638297872340425 0.0309278350515464
GO:BP GO:0043603 cellular amide metabolic process 0.0175208209664369 1241 86 14 0.162790697674419 0.0112812248186946
GO:BP GO:0080134 regulation of response to stress 0.0175208209664369 1443 18 6 0.333333333333333 0.00415800415800416
GO:BP GO:0007155 cell adhesion 0.0178413821620295 1492 36 9 0.25 0.00603217158176944
GO:BP GO:0014070 response to organic cyclic compound 0.0178525200751848 967 26 6 0.230769230769231 0.0062047569803516
GO:BP GO:0022610 biological adhesion 0.0182327177596174 1499 36 9 0.25 0.00600400266844563
GO:BP GO:0097530 granulocyte migration 0.0193861028350759 151 32 3 0.09375 0.0198675496688742
GO:BP GO:0023052 signaling 0.0194669474918445 6810 9 8 0.888888888888889 0.00117474302496329
GO:BP GO:0048524 positive regulation of viral process 0.0194994466373972 91 53 3 0.0566037735849057 0.032967032967033
GO:BP GO:0007154 cell communication 0.0194994466373972 6829 9 8 0.888888888888889 0.00117147459364475
GO:BP GO:0048608 reproductive structure development 0.0194994466373972 429 40 5 0.125 0.0116550116550117
GO:BP GO:0061458 reproductive system development 0.0197830267177063 432 40 5 0.125 0.0115740740740741
GO:BP GO:1990748 cellular detoxification 0.0199984800197874 113 91 4 0.043956043956044 0.0353982300884956
GO:BP GO:0006897 endocytosis 0.0210448132789774 696 8 3 0.375 0.00431034482758621
GO:BP GO:0072594 establishment of protein localization to organelle 0.0211160941499616 584 59 7 0.11864406779661 0.011986301369863
GO:BP GO:0006810 transport 0.0218187348239575 5224 22 13 0.590909090909091 0.0024885145482389
GO:BP GO:0050793 regulation of developmental process 0.0220468412257366 2605 3 3 1 0.00115163147792706
GO:BP GO:0048259 regulation of receptor-mediated endocytosis 0.0226492352390686 112 47 3 0.0638297872340425 0.0267857142857143
GO:BP GO:0042445 hormone metabolic process 0.022740238776039 228 48 4 0.0833333333333333 0.0175438596491228
GO:BP GO:0097237 cellular response to toxic substance 0.0231066303224618 120 91 4 0.043956043956044 0.0333333333333333
GO:BP GO:0019637 organophosphate metabolic process 0.0236157559246486 1041 44 8 0.181818181818182 0.00768491834774256
GO:BP GO:0055088 lipid homeostasis 0.0236855857475373 167 108 5 0.0462962962962963 0.029940119760479
GO:BP GO:0009725 response to hormone 0.0237030778694525 921 108 13 0.12037037037037 0.0141150922909881
GO:BP GO:0030155 regulation of cell adhesion 0.0237030778694525 748 36 6 0.166666666666667 0.00802139037433155
GO:BP GO:0048584 positive regulation of response to stimulus 0.0240875455537363 2344 6 4 0.666666666666667 0.00170648464163823
GO:BP GO:0031623 receptor internalization 0.0240875455537363 116 47 3 0.0638297872340425 0.0258620689655172
GO:BP GO:0046718 viral entry into host cell 0.024359416262772 141 39 3 0.0769230769230769 0.0212765957446809
GO:BP GO:2000147 positive regulation of cell motility 0.0246264759819586 591 32 5 0.15625 0.00846023688663283
GO:BP GO:0019058 viral life cycle 0.0251774810070243 353 53 5 0.0943396226415094 0.0141643059490085
GO:BP GO:0031667 response to nutrient levels 0.0251774810070243 482 56 6 0.107142857142857 0.012448132780083
GO:BP GO:0010243 response to organonitrogen compound 0.0255734288092669 1085 26 6 0.230769230769231 0.00552995391705069
GO:BP GO:0051272 positive regulation of cellular component movement 0.0257740240138846 604 32 5 0.15625 0.00827814569536424
GO:BP GO:0051234 establishment of localization 0.0257740240138846 5372 22 13 0.590909090909091 0.00241995532390171
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0258701611363395 6201 46 25 0.543478260869565 0.00403160780519271
GO:BP GO:0040017 positive regulation of locomotion 0.0258701611363395 606 32 5 0.15625 0.00825082508250825
GO:BP GO:0006915 apoptotic process 0.0262647571211867 1990 20 7 0.35 0.00351758793969849
GO:BP GO:0034754 cellular hormone metabolic process 0.0272463566733249 140 85 4 0.0470588235294118 0.0285714285714286
GO:BP GO:0071827 plasma lipoprotein particle organization 0.0278333407859351 52 115 3 0.0260869565217391 0.0576923076923077
GO:BP GO:0044409 entry into host 0.0278333407859351 154 39 3 0.0769230769230769 0.0194805194805195
GO:BP GO:0051604 protein maturation 0.0284461165358833 306 40 4 0.1 0.0130718954248366
GO:BP GO:0006665 sphingolipid metabolic process 0.0288333944217647 169 72 4 0.0555555555555556 0.0236686390532544
GO:BP GO:0060548 negative regulation of cell death 0.0288333944217647 1038 20 5 0.25 0.00481695568400771
GO:BP GO:0098754 detoxification 0.0290808083657371 134 91 4 0.043956043956044 0.0298507462686567
GO:BP GO:0009991 response to extracellular stimulus 0.0297569573393215 512 56 6 0.107142857142857 0.01171875
GO:BP GO:0007041 lysosomal transport 0.0298535708371768 111 56 3 0.0535714285714286 0.027027027027027
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0307702656131062 363 18 3 0.166666666666667 0.00826446280991736
GO:BP GO:0044267 cellular protein metabolic process 0.0309197831839515 5229 16 10 0.625 0.00191241155096577
GO:BP GO:0001666 response to hypoxia 0.0314282323208237 367 18 3 0.166666666666667 0.00817438692098093
GO:BP GO:0071825 protein-lipid complex subunit organization 0.0314528981852118 56 115 3 0.0260869565217391 0.0535714285714286
GO:BP GO:0046456 icosanoid biosynthetic process 0.0314528981852118 56 115 3 0.0260869565217391 0.0535714285714286
GO:BP GO:1901698 response to nitrogen compound 0.0315198683701 1172 26 6 0.230769230769231 0.00511945392491468
GO:BP GO:0009267 cellular response to starvation 0.0318828687669661 160 80 4 0.05 0.025
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.0319803296212195 536 55 6 0.109090909090909 0.0111940298507463
GO:BP GO:0016477 cell migration 0.0332880524379121 1649 9 4 0.444444444444444 0.00242571255306246
GO:BP GO:0036293 response to decreased oxygen levels 0.0334181829092336 382 18 3 0.166666666666667 0.00785340314136126
GO:BP GO:1901700 response to oxygen-containing compound 0.0335973992545682 1739 30 8 0.266666666666667 0.00460034502587694
GO:BP GO:0012501 programmed cell death 0.0339523812637855 2143 20 7 0.35 0.00326644890340644
GO:BP GO:0048878 chemical homeostasis 0.0341481657871205 1229 108 15 0.138888888888889 0.0122050447518308
GO:BP GO:0033559 unsaturated fatty acid metabolic process 0.0347852132584287 116 115 4 0.0347826086956522 0.0344827586206897
GO:BP GO:0052126 movement in host environment 0.0350579762847032 177 39 3 0.0769230769230769 0.0169491525423729
GO:BP GO:0007399 nervous system development 0.0353825345257023 2449 117 26 0.222222222222222 0.0106165781951817
GO:BP GO:0050891 multicellular organismal water homeostasis 0.0360529662201166 75 93 3 0.032258064516129 0.04
GO:BP GO:0097529 myeloid leukocyte migration 0.0361362219306546 221 32 3 0.09375 0.0135746606334842
GO:BP GO:0009966 regulation of signal transduction 0.0370474894387175 3165 18 8 0.444444444444444 0.00252764612954186
GO:BP GO:0070482 response to oxygen levels 0.0371333692764989 408 18 3 0.166666666666667 0.00735294117647059
GO:BP GO:0048583 regulation of response to stimulus 0.0376044310639989 4278 9 6 0.666666666666667 0.00140252454417952
GO:BP GO:0001501 skeletal system development 0.0394128171637159 504 82 7 0.0853658536585366 0.0138888888888889
GO:BP GO:0048513 animal organ development 0.0406769630635567 3672 3 3 1 0.000816993464052288
GO:BP GO:0002252 immune effector process 0.0412020383853395 1309 86 13 0.151162790697674 0.00993124522536287
GO:BP GO:0051674 localization of cell 0.0412020383853395 1828 9 4 0.444444444444444 0.00218818380743982
GO:BP GO:0048870 cell motility 0.0412020383853395 1828 9 4 0.444444444444444 0.00218818380743982
GO:BP GO:0010035 response to inorganic substance 0.0412654899811301 575 26 4 0.153846153846154 0.00695652173913044
GO:BP GO:0051100 negative regulation of binding 0.0414789459618331 163 47 3 0.0638297872340425 0.0184049079754601
GO:BP GO:0001101 response to acid chemical 0.0415075697701552 135 108 4 0.037037037037037 0.0296296296296296
GO:BP GO:0003006 developmental process involved in reproduction 0.0423441771676163 982 44 7 0.159090909090909 0.00712830957230143
GO:BP GO:0030104 water homeostasis 0.0424528295640158 83 93 3 0.032258064516129 0.036144578313253
GO:BP GO:0006874 cellular calcium ion homeostasis 0.0453845021494098 460 18 3 0.166666666666667 0.00652173913043478
GO:BP GO:0051270 regulation of cellular component movement 0.0455361202882215 1141 39 7 0.179487179487179 0.00613496932515337
GO:BP GO:1903900 regulation of viral life cycle 0.0458871862751735 153 53 3 0.0566037735849057 0.0196078431372549
GO:BP GO:0043112 receptor metabolic process 0.046443957906507 174 47 3 0.0638297872340425 0.0172413793103448
GO:BP GO:0030198 extracellular matrix organization 0.0465871701287324 401 60 5 0.0833333333333333 0.0124688279301746
GO:BP GO:0001889 liver development 0.0465931634207636 148 104 4 0.0384615384615385 0.027027027027027
GO:BP GO:0043062 extracellular structure organization 0.0468869320603377 402 60 5 0.0833333333333333 0.0124378109452736
GO:BP GO:0055074 calcium ion homeostasis 0.0472441297307914 472 18 3 0.166666666666667 0.00635593220338983
GO:BP GO:0045229 external encapsulating structure organization 0.0473350680627456 404 60 5 0.0833333333333333 0.0123762376237624
GO:BP GO:0006643 membrane lipid metabolic process 0.0476694436437212 217 72 4 0.0555555555555556 0.0184331797235023
GO:BP GO:0061008 hepaticobiliary system development 0.048199616373337 151 104 4 0.0384615384615385 0.0264900662251656
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0491866703645078 3210 9 5 0.555555555555556 0.00155763239875389
GO:BP GO:0040011 locomotion 0.0493279229037599 2028 5 3 0.6 0.0014792899408284
GO:BP GO:0002376 immune system process 0.0493279229037599 3278 6 4 0.666666666666667 0.0012202562538133
GO:BP GO:0019538 protein metabolic process 0.0494835428456545 5808 16 10 0.625 0.00172176308539945
GO:BP GO:0051701 biological process involved in interaction with host 0.0494835428456545 221 39 3 0.0769230769230769 0.0135746606334842
GO:BP GO:0007034 vacuolar transport 0.0499403319567813 154 56 3 0.0535714285714286 0.0194805194805195
GO:CC GO:0005783 endoplasmic reticulum 3.62672991745184e-36 1982 90 61 0.677777777777778 0.0307769929364279
GO:CC GO:0098827 endoplasmic reticulum subcompartment 3.0346057573554e-27 1122 80 41 0.5125 0.036541889483066
GO:CC GO:0005789 endoplasmic reticulum membrane 3.0346057573554e-27 1117 80 41 0.5125 0.0367054610564011
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 4.11194087274876e-27 1139 80 41 0.5125 0.0359964881474978
GO:CC GO:0031984 organelle subcompartment 7.64665539213166e-21 1773 80 42 0.525 0.0236886632825719
GO:CC GO:0012505 endomembrane system 1.2075857883574e-20 4640 90 66 0.733333333333333 0.0142241379310345
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 5.40290426669075e-20 128 37 14 0.378378378378378 0.109375
GO:CC GO:0048770 pigment granule 5.15648064037421e-15 105 39 11 0.282051282051282 0.104761904761905
GO:CC GO:0042470 melanosome 5.15648064037421e-15 105 39 11 0.282051282051282 0.104761904761905
GO:CC GO:0031090 organelle membrane 1.53890905950812e-13 3612 80 47 0.5875 0.0130121816168328
GO:CC GO:0005788 endoplasmic reticulum lumen 2.49993927336784e-11 307 88 16 0.181818181818182 0.0521172638436482
GO:CC GO:0034663 endoplasmic reticulum chaperone complex 1.27130702908703e-09 9 16 4 0.25 0.444444444444444
GO:CC GO:0008250 oligosaccharyltransferase complex 4.45206779991813e-09 13 52 5 0.0961538461538462 0.384615384615385
GO:CC GO:0005737 cytoplasm 6.09723790311401e-08 11911 50 49 0.98 0.00411384434556292
GO:CC GO:0033018 sarcoplasmic reticulum lumen 1.41408641317818e-07 10 8 3 0.375 0.3
GO:CC GO:0043231 intracellular membrane-bounded organelle 1.78993133816395e-07 11296 96 83 0.864583333333333 0.00734773371104816
GO:CC GO:0005790 smooth endoplasmic reticulum 1.87141069091462e-07 34 86 6 0.0697674418604651 0.176470588235294
GO:CC GO:0005791 rough endoplasmic reticulum 1.95362809048792e-07 86 60 7 0.116666666666667 0.0813953488372093
GO:CC GO:0016021 integral component of membrane 4.51837889438418e-07 5711 98 56 0.571428571428571 0.00980563824198914
GO:CC GO:0043227 membrane-bounded organelle 4.52809041753916e-07 12858 96 88 0.916666666666667 0.00684398817856587
GO:CC GO:0042582 azurophil granule 5.35741191454131e-07 154 86 9 0.104651162790698 0.0584415584415584
GO:CC GO:0005766 primary lysosome 5.35741191454131e-07 154 86 9 0.104651162790698 0.0584415584415584
GO:CC GO:0031410 cytoplasmic vesicle 7.58239664632615e-07 2424 50 22 0.44 0.00907590759075908
GO:CC GO:0097708 intracellular vesicle 7.58239664632615e-07 2428 50 22 0.44 0.00906095551894563
GO:CC GO:0031224 intrinsic component of membrane 9.73711361085659e-07 5868 98 56 0.571428571428571 0.00954328561690525
GO:CC GO:0070062 extracellular exosome 2.31804459854051e-06 2176 86 28 0.325581395348837 0.0128676470588235
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 2.72091959959416e-06 158 75 8 0.106666666666667 0.0506329113924051
GO:CC GO:0016020 membrane 3.31366069304972e-06 9838 76 61 0.802631578947368 0.00620044724537508
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 3.69974617415071e-06 166 75 8 0.106666666666667 0.0481927710843374
GO:CC GO:0005615 extracellular space 3.75061042262925e-06 3594 9 9 1 0.00250417362270451
GO:CC GO:0005925 focal adhesion 4.13752014678049e-06 420 32 8 0.25 0.019047619047619
GO:CC GO:0043230 extracellular organelle 4.13752014678049e-06 2263 86 28 0.325581395348837 0.0123729562527618
GO:CC GO:1903561 extracellular vesicle 4.13752014678049e-06 2261 86 28 0.325581395348837 0.0123839009287926
GO:CC GO:0030055 cell-substrate junction 4.28452369186992e-06 427 32 8 0.25 0.0187353629976581
GO:CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 1.0597962427931e-05 131 49 6 0.122448979591837 0.0458015267175573
GO:CC GO:0043229 intracellular organelle 1.0597962427931e-05 12491 92 81 0.880434782608696 0.00648466896165239
GO:CC GO:0031982 vesicle 1.36101052922003e-05 4055 61 30 0.491803278688525 0.00739827373612824
GO:CC GO:0031301 integral component of organelle membrane 1.54437223295781e-05 382 56 9 0.160714285714286 0.0235602094240838
GO:CC GO:0043226 organelle 2.20021452373586e-05 14008 96 89 0.927083333333333 0.00635351227869789
GO:CC GO:0005576 extracellular region 2.37598623930828e-05 4567 9 9 1 0.00197065907597986
GO:CC GO:0016529 sarcoplasmic reticulum 2.37598623930828e-05 70 8 3 0.375 0.0428571428571429
GO:CC GO:0031300 intrinsic component of organelle membrane 2.58705457860636e-05 413 56 9 0.160714285714286 0.0217917675544794
GO:CC GO:0016528 sarcoplasm 3.13371137230888e-05 79 8 3 0.375 0.0379746835443038
GO:CC GO:0070161 anchoring junction 5.40345017645818e-05 836 32 9 0.28125 0.0107655502392345
GO:CC GO:0005844 polysome 0.000144754066330644 72 14 3 0.214285714285714 0.0416666666666667
GO:CC GO:0009986 cell surface 0.000157004877393075 899 112 17 0.151785714285714 0.0189098998887653
GO:CC GO:0035577 azurophil granule membrane 0.000179457230970948 57 56 4 0.0714285714285714 0.0701754385964912
GO:CC GO:0030141 secretory granule 0.000198519386979959 851 86 14 0.162790697674419 0.0164512338425382
GO:CC GO:0005622 intracellular anatomical structure 0.000211590942413258 14790 53 52 0.981132075471698 0.0035158891142664
GO:CC GO:0035578 azurophil granule lumen 0.000403467778626019 91 86 5 0.0581395348837209 0.0549450549450549
GO:CC GO:0098796 membrane protein complex 0.00041014621249181 1322 61 14 0.229508196721311 0.010590015128593
GO:CC GO:0048471 perinuclear region of cytoplasm 0.000899942823568316 735 8 4 0.5 0.0054421768707483
GO:CC GO:0005775 vacuolar lumen 0.000899942823568316 174 86 6 0.0697674418604651 0.0344827586206897
GO:CC GO:0030667 secretory granule membrane 0.000931529980035535 303 72 7 0.0972222222222222 0.0231023102310231
GO:CC GO:0070013 intracellular organelle lumen 0.00093313666602101 5402 16 12 0.75 0.00222139948167345
GO:CC GO:0099503 secretory vesicle 0.00112475603880642 1020 86 14 0.162790697674419 0.0137254901960784
GO:CC GO:0043233 organelle lumen 0.00121577129869461 5565 16 12 0.75 0.00215633423180593
GO:CC GO:0031974 membrane-enclosed lumen 0.00121577129869461 5565 16 12 0.75 0.00215633423180593
GO:CC GO:0030139 endocytic vesicle 0.00125095843351139 306 8 3 0.375 0.00980392156862745
GO:CC GO:0000421 autophagosome membrane 0.00134769722882607 41 56 3 0.0535714285714286 0.0731707317073171
GO:CC GO:0005773 vacuole 0.00154907311630824 810 86 12 0.13953488372093 0.0148148148148148
GO:CC GO:0000323 lytic vacuole 0.00193054217549331 712 86 11 0.127906976744186 0.0154494382022472
GO:CC GO:0005764 lysosome 0.00193054217549331 712 86 11 0.127906976744186 0.0154494382022472
GO:CC GO:0043202 lysosomal lumen 0.00209230951421312 97 68 4 0.0588235294117647 0.0412371134020619
GO:CC GO:0009897 external side of plasma membrane 0.00293357832647822 408 109 9 0.0825688073394495 0.0220588235294118
GO:CC GO:0045335 phagocytic vesicle 0.00352197068493852 137 56 4 0.0714285714285714 0.0291970802919708
GO:CC GO:0030054 cell junction 0.003780061429648 2105 61 16 0.262295081967213 0.00760095011876485
GO:CC GO:0042383 sarcolemma 0.00383120846210303 140 98 5 0.0510204081632653 0.0357142857142857
GO:CC GO:0005770 late endosome 0.00587391865867959 275 56 5 0.0892857142857143 0.0181818181818182
GO:CC GO:0030670 phagocytic vesicle membrane 0.00660922754596278 76 56 3 0.0535714285714286 0.0394736842105263
GO:CC GO:0005774 vacuolar membrane 0.0080608356795082 441 56 6 0.107142857142857 0.0136054421768707
GO:CC GO:0005635 nuclear envelope 0.0080608356795082 467 53 6 0.113207547169811 0.012847965738758
GO:CC GO:0005811 lipid droplet 0.00899448043641239 95 108 4 0.037037037037037 0.0421052631578947
GO:CC GO:0032991 protein-containing complex 0.00927205835970927 5548 19 12 0.631578947368421 0.00216294160057678
GO:CC GO:0001669 acrosomal vesicle 0.0108410092372568 119 44 3 0.0681818181818182 0.0252100840336134
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0108410092372568 779 72 9 0.125 0.0115532734274711
GO:CC GO:0005776 autophagosome 0.0113827477380016 98 56 3 0.0535714285714286 0.0306122448979592
GO:CC GO:0012506 vesicle membrane 0.0118147076920241 800 72 9 0.125 0.01125
GO:CC GO:0034774 secretory granule lumen 0.0121350870878792 320 86 6 0.0697674418604651 0.01875
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0126405551613041 324 86 6 0.0697674418604651 0.0185185185185185
GO:CC GO:0031983 vesicle lumen 0.0127269753224109 326 86 6 0.0697674418604651 0.0184049079754601
GO:CC GO:0101002 ficolin-1-rich granule 0.0140705292375302 184 68 4 0.0588235294117647 0.0217391304347826
GO:CC GO:0005765 lysosomal membrane 0.0169464243002123 383 56 5 0.0892857142857143 0.0130548302872063
GO:CC GO:0098852 lytic vacuole membrane 0.0169464243002123 383 56 5 0.0892857142857143 0.0130548302872063
GO:CC GO:0098588 bounding membrane of organelle 0.0181211015937084 2158 78 17 0.217948717948718 0.00787766450417053
GO:CC GO:0005768 endosome 0.0237888159779912 987 56 8 0.142857142857143 0.00810536980749747
GO:CC GO:0031902 late endosome membrane 0.0239626983224787 140 56 3 0.0535714285714286 0.0214285714285714
GO:CC GO:0031967 organelle envelope 0.0248514518128483 1237 55 9 0.163636363636364 0.00727566693613581
GO:CC GO:0031975 envelope 0.0248514518128483 1237 55 9 0.163636363636364 0.00727566693613581
GO:CC GO:0098552 side of membrane 0.0263928753989332 619 109 9 0.0825688073394495 0.0145395799676898
GO:CC GO:0005634 nucleus 0.0263928753989332 7592 15 11 0.733333333333333 0.00144889357218124
GO:CC GO:0030666 endocytic vesicle membrane 0.0312486295521324 159 56 3 0.0535714285714286 0.0188679245283019
GO:CC GO:1990904 ribonucleoprotein complex 0.0333977319619094 688 14 3 0.214285714285714 0.00436046511627907
GO:CC GO:0005829 cytosol 0.0404556176628962 5303 16 9 0.5625 0.00169715255515746
GO:CC GO:1990234 transferase complex 0.0465159421737085 804 37 5 0.135135135135135 0.00621890547263682
GO:CC GO:1902494 catalytic complex 0.0467413330254928 1441 37 7 0.189189189189189 0.00485773768216516
GO:CC GO:0042579 microbody 0.0467413330254928 141 77 3 0.038961038961039 0.0212765957446809
GO:CC GO:0005777 peroxisome 0.0467413330254928 141 77 3 0.038961038961039 0.0212765957446809
GO:CC GO:0071944 cell periphery 0.0469299612182231 6169 61 28 0.459016393442623 0.00453882314799805
GO:MF GO:0016491 oxidoreductase activity 4.59427531890729e-08 771 91 21 0.230769230769231 0.0272373540856031
GO:MF GO:0015037 peptide disulfide oxidoreductase activity 1.02561948131511e-07 13 21 4 0.19047619047619 0.307692307692308
GO:MF GO:0016853 isomerase activity 1.02561948131511e-07 169 35 8 0.228571428571429 0.0473372781065089
GO:MF GO:0016860 intramolecular oxidoreductase activity 1.02561948131511e-07 53 35 6 0.171428571428571 0.113207547169811
GO:MF GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds 3.69040289298139e-07 19 21 4 0.19047619047619 0.210526315789474
GO:MF GO:0003756 protein disulfide isomerase activity 3.69040289298139e-07 19 21 4 0.19047619047619 0.210526315789474
GO:MF GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 7.08838729673871e-06 167 89 9 0.101123595505618 0.0538922155688623
GO:MF GO:0015036 disulfide oxidoreductase activity 7.11652379891682e-06 41 21 4 0.19047619047619 0.0975609756097561
GO:MF GO:0051082 unfolded protein binding 8.198471735717e-06 112 9 4 0.444444444444444 0.0357142857142857
GO:MF GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity 9.91652451792536e-06 5 52 3 0.0576923076923077 0.6
GO:MF GO:0004576 oligosaccharyl transferase activity 1.79945662613538e-05 6 52 3 0.0576923076923077 0.5
GO:MF GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 2.25306884514518e-05 60 21 4 0.19047619047619 0.0666666666666667
GO:MF GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water 2.82947023936692e-05 5 80 3 0.0375 0.6
GO:MF GO:0003824 catalytic activity 0.000276237538463108 5896 91 49 0.538461538461538 0.00831071913161465
GO:MF GO:0003723 RNA binding 0.000276237538463108 1943 16 9 0.5625 0.00463201235203294
GO:MF GO:0050750 low-density lipoprotein particle receptor binding 0.000693726924874727 23 47 3 0.0638297872340425 0.130434782608696
GO:MF GO:0070325 lipoprotein particle receptor binding 0.00114477956202625 28 47 3 0.0638297872340425 0.107142857142857
GO:MF GO:0005506 iron ion binding 0.00227543617930419 155 89 6 0.0674157303370786 0.0387096774193548
GO:MF GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00311233578684895 30 65 3 0.0461538461538462 0.1
GO:MF GO:0016758 transferase activity, transferring hexosyl groups 0.00412499707030385 205 78 6 0.0769230769230769 0.0292682926829268
GO:MF GO:0016229 steroid dehydrogenase activity 0.00440476808752837 35 65 3 0.0461538461538462 0.0857142857142857
GO:MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00462907108752577 125 85 5 0.0588235294117647 0.04
GO:MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 0.00659482541289598 137 85 5 0.0588235294117647 0.0364963503649635
GO:MF GO:0050839 cell adhesion molecule binding 0.0110482470362536 546 26 5 0.192307692307692 0.00915750915750916
GO:MF GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 0.0127488227780624 99 83 4 0.0481927710843374 0.0404040404040404
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.0141390019276065 283 78 6 0.0769230769230769 0.0212014134275618
GO:MF GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 0.0145462982794324 48 89 3 0.0337078651685393 0.0625
GO:MF GO:0044877 protein-containing complex binding 0.0157437339565853 1287 20 6 0.3 0.00466200466200466
GO:MF GO:0005496 steroid binding 0.0159690017006156 100 46 3 0.0652173913043478 0.03
GO:MF GO:0097159 organic cyclic compound binding 0.0165156432772657 6309 17 12 0.705882352941177 0.0019020446980504
GO:MF GO:0031625 ubiquitin protein ligase binding 0.0191039825459083 296 18 3 0.166666666666667 0.0101351351351351
GO:MF GO:0005515 protein binding 0.0193508695320824 14767 87 79 0.908045977011494 0.00534976637096228
GO:MF GO:0016798 hydrolase activity, acting on glycosyl bonds 0.0195622632033737 139 83 4 0.0481927710843374 0.0287769784172662
GO:MF GO:0005102 signaling receptor binding 0.0195622632033737 1672 8 4 0.5 0.00239234449760766
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.0195622632033737 314 18 3 0.166666666666667 0.00955414012738853
GO:MF GO:0005509 calcium ion binding 0.0204878732021249 721 9 3 0.333333333333333 0.00416088765603329
GO:MF GO:0003676 nucleic acid binding 0.0204878732021249 4276 16 9 0.5625 0.00210477081384471
GO:MF GO:1901363 heterocyclic compound binding 0.0204878732021249 6228 16 11 0.6875 0.00176621708413616
GO:MF GO:0016829 lyase activity 0.0277588128527877 203 69 4 0.0579710144927536 0.0197044334975369
GO:MF GO:0016209 antioxidant activity 0.0303279129665941 87 91 3 0.032967032967033 0.0344827586206897
GO:MF GO:0043177 organic acid binding 0.0310015946308321 120 67 3 0.0447761194029851 0.025
GO:MF GO:0019899 enzyme binding 0.0322161724835762 2074 58 13 0.224137931034483 0.00626808100289296
GO:MF GO:0045296 cadherin binding 0.0341217608725648 333 26 3 0.115384615384615 0.00900900900900901
HPA HPA:0180053 epididymis; glandular cells[High] 0.000516268607446166 1779 61 26 0.426229508196721 0.0146149522203485
HPA HPA:0290402 liver; hepatocytes[≥Medium] 0.00126868435111948 3640 70 42 0.6 0.0115384615384615
HPA HPA:0390000 prostate 0.00191291839860794 6528 53 46 0.867924528301887 0.00704656862745098
HPA HPA:0090941 cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] 0.00191291839860794 448 85 13 0.152941176470588 0.0290178571428571
HPA HPA:0091071 cerebellum; white matter cells - cytoplasm/membrane[≥Low] 0.00191291839860794 292 65 9 0.138461538461538 0.0308219178082192
HPA HPA:0390051 prostate; glandular cells[≥Low] 0.00191291839860794 6528 53 46 0.867924528301887 0.00704656862745098
HPA HPA:0180052 epididymis; glandular cells[≥Medium] 0.00191291839860794 5560 62 48 0.774193548387097 0.00863309352517986
HPA HPA:0180051 epididymis; glandular cells[≥Low] 0.00191291839860794 7171 47 43 0.914893617021277 0.00599637428531586
HPA HPA:0290000 liver 0.00191291839860794 6158 53 44 0.830188679245283 0.00714517700552127
HPA HPA:0290401 liver; hepatocytes[≥Low] 0.00191291839860794 5611 56 44 0.785714285714286 0.00784173944038496
HPA HPA:0180000 epididymis 0.00191291839860794 7171 47 43 0.914893617021277 0.00599637428531586
HPA HPA:0430053 seminal vesicle; glandular cells[High] 0.00191291839860794 1410 20 10 0.5 0.00709219858156028
HPA HPA:0480052 small intestine; glandular cells[≥Medium] 0.00191291839860794 6461 53 45 0.849056603773585 0.0069648661197957
HPA HPA:0590053 thyroid gland; glandular cells[High] 0.00191291839860794 1804 11 8 0.727272727272727 0.00443458980044346
HPA HPA:0570732 testis; Leydig cells[≥Medium] 0.00191291839860794 5295 56 43 0.767857142857143 0.00812086874409821
HPA HPA:0390052 prostate; glandular cells[≥Medium] 0.00191291839860794 4699 56 39 0.696428571428571 0.00829963822089806
HPA HPA:0570733 testis; Leydig cells[High] 0.00191291839860794 1718 70 25 0.357142857142857 0.0145518044237485
HPA HPA:0150052 duodenum; glandular cells[≥Medium] 0.00199547248370269 6480 53 45 0.849056603773585 0.00694444444444444
HPA HPA:0350473 pancreas; exocrine glandular cells[High] 0.00223123784478489 1879 42 18 0.428571428571429 0.00957956359765833
HPA HPA:0060101 bronchus; respiratory epithelial cells[≥Low] 0.00308039890038934 6226 41 35 0.853658536585366 0.0056215868936717
HPA HPA:0540053 stomach 1; glandular cells[High] 0.00389397673730484 2365 39 19 0.487179487179487 0.0080338266384778
HPA HPA:0430052 seminal vesicle; glandular cells[≥Medium] 0.0040473784765149 5096 56 40 0.714285714285714 0.00784929356357928
HPA HPA:0091001 cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] 0.00429295312325745 343 67 9 0.134328358208955 0.0262390670553936
HPA HPA:0150053 duodenum; glandular cells[High] 0.00429295312325745 2767 59 28 0.474576271186441 0.010119262739429
HPA HPA:0220052 gallbladder; glandular cells[≥Medium] 0.00456457219913674 6461 53 44 0.830188679245283 0.00681009131713357
HPA HPA:0510651 soft tissue 2; fibroblasts[≥Low] 0.00462149846573726 4037 62 37 0.596774193548387 0.00916522169928164
HPA HPA:0160053 endometrium 1; glandular cells[High] 0.00462149846573726 1413 9 6 0.666666666666667 0.00424628450106157
HPA HPA:0320101 nasopharynx; respiratory epithelial cells[≥Low] 0.00462149846573726 6079 41 34 0.829268292682927 0.00559302516861326
HPA HPA:0210051 fallopian tube; glandular cells[≥Low] 0.00465449290790346 6089 41 34 0.829268292682927 0.00558383971095418
HPA HPA:0090922 cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] 0.00548253120920233 179 59 6 0.101694915254237 0.0335195530726257
HPA HPA:0510652 soft tissue 2; fibroblasts[≥Medium] 0.00548253120920233 2543 62 27 0.435483870967742 0.0106173810460087
HPA HPA:0300412 lung; macrophages[≥Medium] 0.00565654505250114 4732 41 29 0.707317073170732 0.00612848689771767
HPA HPA:0150000 duodenum 0.00565654505250114 7606 53 48 0.905660377358491 0.00631080725742835
HPA HPA:0150051 duodenum; glandular cells[≥Low] 0.00565654505250114 7606 53 48 0.905660377358491 0.00631080725742835
HPA HPA:0170053 endometrium 2; glandular cells[High] 0.00613278128416676 1282 22 9 0.409090909090909 0.00702028081123245
HPA HPA:0170052 endometrium 2; glandular cells[≥Medium] 0.00613278128416676 4758 41 29 0.707317073170732 0.00609499789827659
HPA HPA:0130051 colon; glandular cells[≥Low] 0.00647203860281701 7414 53 47 0.886792452830189 0.00633935797140545
HPA HPA:0030051 appendix; glandular cells[≥Low] 0.00647203860281701 7142 53 46 0.867924528301887 0.00644077289274713
HPA HPA:0360051 parathyroid gland; glandular cells[≥Low] 0.00647203860281701 5767 62 46 0.741935483870968 0.00797641754811861
HPA HPA:0360000 parathyroid gland 0.00647203860281701 5767 62 46 0.741935483870968 0.00797641754811861
HPA HPA:0160052 endometrium 1; glandular cells[≥Medium] 0.00647203860281701 5014 62 42 0.67741935483871 0.00837654567211807
HPA HPA:0090921 cerebellum; GLUC cells - cytoplasm/membrane[≥Low] 0.00647203860281701 197 59 6 0.101694915254237 0.0304568527918782
HPA HPA:0460651 skin 1; fibroblasts[≥Low] 0.00647203860281701 4726 56 37 0.660714285714286 0.00782903089293271
HPA HPA:0170000 endometrium 2 0.00647203860281701 6755 43 37 0.86046511627907 0.00547742413027387
HPA HPA:0430000 seminal vesicle 0.00659399382307362 6672 53 44 0.830188679245283 0.0065947242206235
HPA HPA:0550053 stomach 2; glandular cells[High] 0.00659399382307362 2350 62 25 0.403225806451613 0.0106382978723404
HPA HPA:0430051 seminal vesicle; glandular cells[≥Low] 0.00659399382307362 6672 53 44 0.830188679245283 0.0065947242206235
HPA HPA:0160252 endometrium 1; cells in endometrial stroma[≥Medium] 0.00698674503512617 2142 10 7 0.7 0.00326797385620915
HPA HPA:0590000 thyroid gland 0.00727204433229051 6963 53 45 0.849056603773585 0.00646273158121499
HPA HPA:0590051 thyroid gland; glandular cells[≥Low] 0.00727204433229051 6963 53 45 0.849056603773585 0.00646273158121499
HPA HPA:0590052 thyroid gland; glandular cells[≥Medium] 0.00727204433229051 5454 62 44 0.709677419354839 0.00806747341400807
HPA HPA:0060102 bronchus; respiratory epithelial cells[≥Medium] 0.00727204433229051 5184 56 39 0.696428571428571 0.00752314814814815
HPA HPA:0400051 rectum; glandular cells[≥Low] 0.00756060858618977 7496 53 47 0.886792452830189 0.00627001067235859
HPA HPA:0400000 rectum 0.00756060858618977 7496 53 47 0.886792452830189 0.00627001067235859
HPA HPA:0350000 pancreas 0.00770384030827117 7242 53 46 0.867924528301887 0.00635183650925159
HPA HPA:0130053 colon; glandular cells[High] 0.00795655659708643 2538 53 23 0.433962264150943 0.00906225374310481
HPA HPA:0130052 colon; glandular cells[≥Medium] 0.00795655659708643 6278 53 42 0.792452830188679 0.00669002867155145
HPA HPA:0020051 adrenal gland; glandular cells[≥Low] 0.00810575086793631 7265 53 46 0.867924528301887 0.0063317274604267
HPA HPA:0020000 adrenal gland 0.00818647456039631 7271 53 46 0.867924528301887 0.00632650254435428
HPA HPA:0540052 stomach 1; glandular cells[≥Medium] 0.00824239676611881 6201 42 34 0.80952380952381 0.00548298661506209
HPA HPA:0060000 bronchus 0.00824239676611881 7277 53 46 0.867924528301887 0.00632128624433145
HPA HPA:0091072 cerebellum; white matter cells - cytoplasm/membrane[≥Medium] 0.00883147244088604 225 59 6 0.101694915254237 0.0266666666666667
HPA HPA:0300411 lung; macrophages[≥Low] 0.00883147244088604 6645 47 39 0.829787234042553 0.00586907449209932
HPA HPA:0250132 hippocampus; neuronal cells[≥Medium] 0.00883147244088604 4126 56 33 0.589285714285714 0.00799806107610276
HPA HPA:0030000 appendix 0.00931998595950333 7584 53 47 0.886792452830189 0.00619725738396624
HPA HPA:0480000 small intestine 0.00931998595950333 7593 53 47 0.886792452830189 0.00618991176083235
HPA HPA:0210052 fallopian tube; glandular cells[≥Medium] 0.00931998595950333 5023 41 29 0.707317073170732 0.00577344216603623
HPA HPA:0480051 small intestine; glandular cells[≥Low] 0.00931998595950333 7593 53 47 0.886792452830189 0.00618991176083235
HPA HPA:0600000 tonsil 0.00950916918018529 7618 43 39 0.906976744186046 0.00511945392491468
HPA HPA:0160051 endometrium 1; glandular cells[≥Low] 0.0096242796110486 6663 43 36 0.837209302325581 0.00540297163439892
HPA HPA:0380523 placenta; trophoblastic cells[High] 0.00993641469403773 1998 41 16 0.390243902439024 0.00800800800800801
HPA HPA:0091051 cerebellum; synaptic glomeruli - capsule[≥Low] 0.0100446200448825 92 61 4 0.0655737704918033 0.0434782608695652
HPA HPA:0170252 endometrium 2; cells in endometrial stroma[≥Medium] 0.0105978094377566 1722 10 6 0.6 0.00348432055749129
HPA HPA:0090942 cerebellum; Purkinje cells - cytoplasm/membrane[≥Medium] 0.0105978094377566 368 67 8 0.119402985074627 0.0217391304347826
HPA HPA:0320000 nasopharynx 0.0115052450374086 7035 43 37 0.86046511627907 0.00525941719971571
HPA HPA:0570731 testis; Leydig cells[≥Low] 0.0119815651218441 7041 47 40 0.851063829787234 0.00568101121999716
HPA HPA:0130000 colon 0.0126252508705244 7959 53 48 0.905660377358491 0.00603090840557859
HPA HPA:0291161 liver; cholangiocytes[≥Low] 0.0129629920871012 3867 11 9 0.818181818181818 0.00232738557020946
HPA HPA:0380522 placenta; trophoblastic cells[≥Medium] 0.0132826963741412 5074 52 35 0.673076923076923 0.00689791091840757
HPA HPA:0570801 testis; sertoli cells[≥Low] 0.0132826963741412 2256 11 7 0.636363636363636 0.00310283687943262
HPA HPA:0040082 bone marrow; hematopoietic cells[≥Medium] 0.0137272073326463 4126 9 8 0.888888888888889 0.00193892389723703
HPA HPA:0340461 ovary; ovarian stroma cells[≥Low] 0.01423133791725 3894 41 24 0.585365853658537 0.0061633281972265
HPA HPA:0091002 cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] 0.0144592106817046 309 67 7 0.104477611940299 0.0226537216828479
HPA HPA:0480053 small intestine; glandular cells[High] 0.0144592106817046 2723 50 22 0.44 0.00807932427469703
HPA HPA:0160251 endometrium 1; cells in endometrial stroma[≥Low] 0.0144592106817046 3962 11 9 0.818181818181818 0.00227158001009591
HPA HPA:0540000 stomach 1 0.0145728306511319 7493 53 46 0.867924528301887 0.00613906312558388
HPA HPA:0540051 stomach 1; glandular cells[≥Low] 0.0145728306511319 7493 53 46 0.867924528301887 0.00613906312558388
HPA HPA:0220000 gallbladder 0.0148550011652869 7503 53 46 0.867924528301887 0.00613088098094096
HPA HPA:0220051 gallbladder; glandular cells[≥Low] 0.0148550011652869 7503 53 46 0.867924528301887 0.00613088098094096
HPA HPA:0350471 pancreas; exocrine glandular cells[≥Low] 0.0152942743252713 6778 53 43 0.811320754716981 0.00634405429330186
HPA HPA:0170051 endometrium 2; glandular cells[≥Low] 0.0157199533606948 6568 43 35 0.813953488372093 0.00532886723507917
HPA HPA:0300000 lung 0.0159288417164957 7163 47 40 0.851063829787234 0.00558425240820885
HPA HPA:0600221 tonsil; squamous epithelial cells[≥Low] 0.0161963213740707 6518 16 15 0.9375 0.00230131942313593
HPA HPA:0160000 endometrium 1 0.0169300166176287 6894 43 36 0.837209302325581 0.00522193211488251
HPA HPA:0550052 stomach 2; glandular cells[≥Medium] 0.0169572867361436 6134 56 42 0.75 0.00684708183893055
HPA HPA:0460652 skin 1; fibroblasts[≥Medium] 0.0185440062521207 3304 56 27 0.482142857142857 0.00817191283292978
HPA HPA:0400052 rectum; glandular cells[≥Medium] 0.0193707298026113 6410 37 30 0.810810810810811 0.0046801872074883
HPA HPA:0020052 adrenal gland; glandular cells[≥Medium] 0.0223442174149639 5867 46 34 0.739130434782609 0.0057951252769729
HPA HPA:0210000 fallopian tube 0.0231512526587703 7302 43 37 0.86046511627907 0.00506710490276637
HPA HPA:0460671 skin 1; melanocytes[≥Low] 0.0234360321902764 5378 11 10 0.909090909090909 0.00185942729639271
HPA HPA:0270361 kidney; cells in tubules[≥Low] 0.0240517988305224 7652 53 46 0.867924528301887 0.00601150026136958
HPA HPA:0170251 endometrium 2; cells in endometrial stroma[≥Low] 0.0240894559026913 3410 11 8 0.727272727272727 0.00234604105571848
HPA HPA:0110000 cervix, uterine 0.0240894559026913 6778 11 11 1 0.00162289760991443
HPA HPA:0301172 lung; alveolar cells[≥Medium] 0.0240894559026913 2863 56 24 0.428571428571429 0.008382815228781
HPA HPA:0080131 caudate; neuronal cells[≥Low] 0.0240894559026913 6042 56 41 0.732142857142857 0.00678583250579278
HPA HPA:0360052 parathyroid gland; glandular cells[≥Medium] 0.0240894559026913 4306 62 35 0.564516129032258 0.00812819321876451
HPA HPA:0270000 kidney 0.0240894559026913 7944 48 43 0.895833333333333 0.00541289023162135
HPA HPA:0050091 breast; myoepithelial cells[≥Low] 0.0262915129575306 5551 42 30 0.714285714285714 0.00540443163393983
HPA HPA:0550051 stomach 2; glandular cells[≥Low] 0.0266061371800984 7453 53 45 0.849056603773585 0.00603783711257212
HPA HPA:0100132 cerebral cortex; neuronal cells[≥Medium] 0.0266061371800984 4883 56 35 0.625 0.00716772475936924
HPA HPA:0550000 stomach 2 0.0266061371800984 7453 53 45 0.849056603773585 0.00603783711257212
HPA HPA:0510000 soft tissue 2 0.02669112617827 5082 56 36 0.642857142857143 0.00708382526564345
HPA HPA:0130241 colon; peripheral nerve/ganglion[≥Low] 0.02669112617827 5037 42 28 0.666666666666667 0.00555886440341473
HPA HPA:0190221 esophagus; squamous epithelial cells[≥Low] 0.0268778311393452 6524 53 41 0.773584905660377 0.0062844880441447
HPA HPA:0190000 esophagus 0.0268778311393452 6524 53 41 0.773584905660377 0.0062844880441447
HPA HPA:0250131 hippocampus; neuronal cells[≥Low] 0.0276452100951955 6101 56 41 0.732142857142857 0.00672020980167186
HPA HPA:0500651 soft tissue 1; fibroblasts[≥Low] 0.0276452100951955 4156 56 31 0.553571428571429 0.00745909528392685
HPA HPA:0091041 cerebellum; processes in white matter[≥Low] 0.0314464625781718 207 67 5 0.0746268656716418 0.0241545893719807
HPA HPA:0030052 appendix; glandular cells[≥Medium] 0.0316606316466714 5767 59 41 0.694915254237288 0.00710941564071441
HPA HPA:0130201 colon; endothelial cells[≥Low] 0.0317025024926566 5671 11 10 0.909090909090909 0.00176335743255158
HPA HPA:0610832 urinary bladder; urothelial cells[≥Medium] 0.0320810048349556 5819 41 30 0.731707317073171 0.00515552500429627
HPA HPA:0080000 caudate 0.0321321987374007 6817 53 42 0.792452830188679 0.0061610679184392
HPA HPA:0130202 colon; endothelial cells[≥Medium] 0.0326604862791945 3655 11 8 0.727272727272727 0.00218878248974008
HPA HPA:0050051 breast; glandular cells[≥Low] 0.0348593698919068 6659 47 37 0.787234042553192 0.00555638984832557
HPA HPA:0610831 urinary bladder; urothelial cells[≥Low] 0.0350981085986536 7141 11 11 1 0.00154040050413107
HPA HPA:0610000 urinary bladder 0.0350981085986536 7141 11 11 1 0.00154040050413107
HPA HPA:0320102 nasopharynx; respiratory epithelial cells[≥Medium] 0.0375079464629058 5010 56 35 0.625 0.00698602794411178
HPA HPA:0570802 testis; sertoli cells[≥Medium] 0.0377173968334978 1662 39 12 0.307692307692308 0.0072202166064982
HPA HPA:0350472 pancreas; exocrine glandular cells[≥Medium] 0.0388701439474789 5157 62 39 0.629032258064516 0.00756253635834788
HPA HPA:0380521 placenta; trophoblastic cells[≥Low] 0.0424579245340942 6388 52 39 0.75 0.00610519724483406
HPA HPA:0380513 placenta; decidual cells[High] 0.0433845147867135 1144 50 11 0.22 0.00961538461538462
HPA HPA:0380000 placenta 0.0437330785473105 7321 11 11 1 0.00150252697718891
HPA HPA:0530000 spleen 0.0454056776359947 5756 52 36 0.692307692307692 0.00625434329395414
HPA HPA:0530711 spleen; cells in red pulp[≥Low] 0.0454056776359947 5195 9 8 0.888888888888889 0.00153994225216554
HPA HPA:0290403 liver; hepatocytes[High] 0.0458747293787716 839 77 12 0.155844155844156 0.0143027413587604
HPA HPA:0040083 bone marrow; hematopoietic cells[High] 0.0478493307890608 1376 22 7 0.318181818181818 0.00508720930232558
HPA HPA:0500112 soft tissue 1; chondrocytes[≥Medium] 0.0478493307890608 1395 37 10 0.27027027027027 0.00716845878136201
HPA HPA:0351181 pancreas; pancreatic endocrine cells[≥Low] 0.0478493307890608 5497 56 37 0.660714285714286 0.00673094415135529
HPA HPA:0420051 salivary gland; glandular cells[≥Low] 0.0478493307890608 6744 53 41 0.773584905660377 0.00607947805456702
HPA HPA:0420000 salivary gland 0.0478493307890608 6744 53 41 0.773584905660377 0.00607947805456702
HPA HPA:0340000 ovary 0.0482463134025095 5298 42 28 0.666666666666667 0.00528501321253303
HPA HPA:0400053 rectum; glandular cells[High] 0.0484338267874124 2687 51 20 0.392156862745098 0.00744324525493115
HPA HPA:0091003 cerebellum; molecular layer cells - cytoplasm/membrane[High] 0.0488150137736559 182 59 4 0.0677966101694915 0.021978021978022
HPA HPA:0090901 cerebellum; Bergmann glia - cytoplasm/membrane[≥Low] 0.0488938076679721 106 56 3 0.0535714285714286 0.0283018867924528
KEGG KEGG:00100 Steroid biosynthesis 3.9625872533863e-13 20 89 10 0.112359550561798 0.5
KEGG KEGG:04141 Protein processing in endoplasmic reticulum 1.03868421326869e-08 170 37 11 0.297297297297297 0.0647058823529412
KEGG KEGG:00900 Terpenoid backbone biosynthesis 7.60530545991581e-05 22 77 5 0.0649350649350649 0.227272727272727
KEGG KEGG:00513 Various types of N-glycan biosynthesis 0.000157781995885984 39 52 5 0.0961538461538462 0.128205128205128
KEGG KEGG:01100 Metabolic pathways 0.000453039935393644 1490 80 31 0.3875 0.0208053691275168
KEGG KEGG:01212 Fatty acid metabolism 0.000453039935393644 57 80 6 0.075 0.105263157894737
KEGG KEGG:04612 Antigen processing and presentation 0.00096542493875205 69 9 3 0.333333333333333 0.0434782608695652
KEGG KEGG:01040 Biosynthesis of unsaturated fatty acids 0.002321287377909 27 80 4 0.05 0.148148148148148
KEGG KEGG:00510 N-Glycan biosynthesis 0.00442730100600207 50 52 4 0.0769230769230769 0.08
KEGG KEGG:04142 Lysosome 0.00468580010668425 128 83 7 0.0843373493975904 0.0546875
KEGG KEGG:00511 Other glycan degradation 0.00889695001657318 18 83 3 0.036144578313253 0.166666666666667
KEGG KEGG:04918 Thyroid hormone synthesis 0.00974980386325168 75 21 3 0.142857142857143 0.04
KEGG KEGG:03060 Protein export 0.0109965979718833 23 73 3 0.0410958904109589 0.130434782608696
KEGG KEGG:00650 Butanoate metabolism 0.014352890113703 28 67 3 0.0447761194029851 0.107142857142857
KEGG KEGG:04979 Cholesterol metabolism 0.0260875310215114 50 47 3 0.0638297872340425 0.06
MIRNA MIRNA:hsa-miR-1-3p hsa-miR-1-3p 0.0333257458994517 915 8 5 0.625 0.00546448087431694
MIRNA MIRNA:hsa-miR-192-5p hsa-miR-192-5p 0.0333257458994517 989 90 18 0.2 0.0182002022244692
MIRNA MIRNA:hsa-miR-1909-3p hsa-miR-1909-3p 0.0383085900188686 182 8 3 0.375 0.0164835164835165
MIRNA MIRNA:hsa-miR-3179 hsa-miR-3179 0.0383085900188686 182 8 3 0.375 0.0164835164835165
MIRNA MIRNA:hsa-miR-92a-3p hsa-miR-92a-3p 0.0421517362998442 1404 33 11 0.333333333333333 0.00783475783475784
MIRNA MIRNA:hsa-miR-6782-5p hsa-miR-6782-5p 0.0421517362998442 95 18 3 0.166666666666667 0.0315789473684211
MIRNA MIRNA:hsa-miR-328-3p hsa-miR-328-3p 0.0421517362998442 132 64 5 0.078125 0.0378787878787879
REAC REAC:R-HSA-191273 Cholesterol biosynthesis 8.3998788489523e-24 24 89 15 0.168539325842697 0.625
REAC REAC:R-HSA-8957322 Metabolism of steroids 1.42428845000602e-15 148 89 19 0.213483146067416 0.128378378378378
REAC REAC:R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 1.16161773889562e-12 40 89 11 0.123595505617978 0.275
REAC REAC:R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 1.16161773889562e-12 53 89 12 0.134831460674157 0.226415094339623
REAC REAC:R-HSA-556833 Metabolism of lipids 8.63680518305109e-09 730 89 26 0.292134831460674 0.0356164383561644
REAC REAC:R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 1.79617166137757e-06 9 9 3 0.333333333333333 0.333333333333333
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 2.76853755561117e-06 113 73 9 0.123287671232877 0.079646017699115
REAC REAC:R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 2.76853755561117e-06 11 9 3 0.333333333333333 0.272727272727273
REAC REAC:R-HSA-6807062 Cholesterol biosynthesis via lathosterol 7.53747449794522e-06 4 43 3 0.0697674418604651 0.75
REAC REAC:R-HSA-6807047 Cholesterol biosynthesis via desmosterol 7.53747449794522e-06 4 43 3 0.0697674418604651 0.75
REAC REAC:R-HSA-381119 Unfolded Protein Response (UPR) 1.7211299465834e-05 91 9 4 0.444444444444444 0.043956043956044
REAC REAC:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 2.44228950787724e-05 25 9 3 0.333333333333333 0.12
REAC REAC:R-HSA-75105 Fatty acyl-CoA biosynthesis 0.000886092156155639 37 55 4 0.0727272727272727 0.108108108108108
REAC REAC:R-HSA-72766 Translation 0.00125281319232417 292 37 7 0.189189189189189 0.023972602739726
REAC REAC:R-HSA-114608 Platelet degranulation 0.0022818045281251 125 9 3 0.333333333333333 0.024
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.00242118701942405 130 9 3 0.333333333333333 0.0230769230769231
REAC REAC:R-HSA-1430728 Metabolism 0.00329127893285975 2070 89 32 0.359550561797753 0.0154589371980676
REAC REAC:R-HSA-8957275 Post-translational protein phosphorylation 0.00329127893285975 107 86 6 0.0697674418604651 0.0560747663551402
REAC REAC:R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 0.00341957475930527 24 55 3 0.0545454545454545 0.125
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.00569275216834644 474 86 12 0.13953488372093 0.0253164556962025
REAC REAC:R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.00637332676777772 124 86 6 0.0697674418604651 0.0483870967741935
REAC REAC:R-HSA-8964038 LDL clearance 0.00643651169742932 19 93 3 0.032258064516129 0.157894736842105
REAC REAC:R-HSA-392499 Metabolism of proteins 0.00861088313497566 1961 22 11 0.5 0.00560938296787353
REAC REAC:R-HSA-168255 Influenza Infection 0.00917904916117754 152 14 3 0.214285714285714 0.0197368421052632
REAC REAC:R-HSA-76002 Platelet activation, signaling and aggregation 0.010191734017021 258 9 3 0.333333333333333 0.0116279069767442
REAC REAC:R-HSA-446203 Asparagine N-linked glycosylation 0.0112351492005404 304 74 8 0.108108108108108 0.0263157894736842
REAC REAC:R-HSA-174824 Plasma lipoprotein assembly, remodeling, and clearance 0.0146609854662078 67 38 3 0.0789473684210526 0.0447761194029851
REAC REAC:R-HSA-8964043 Plasma lipoprotein clearance 0.0215479270880541 32 93 3 0.032258064516129 0.09375
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.0229903543644052 370 9 3 0.333333333333333 0.00810810810810811
REAC REAC:R-HSA-428157 Sphingolipid metabolism 0.0377896877806776 86 88 4 0.0454545454545455 0.0465116279069767
REAC REAC:R-HSA-1660662 Glycosphingolipid metabolism 0.0377896877806776 44 88 3 0.0340909090909091 0.0681818181818182
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.0398556699085991 546 16 4 0.25 0.00732600732600733
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.0414377182291566 560 16 4 0.25 0.00714285714285714
REAC REAC:R-HSA-597592 Post-translational protein modification 0.0418403918722174 1377 11 5 0.454545454545455 0.00363108206245461
REAC REAC:R-HSA-8978868 Fatty acid metabolism 0.0422309888302949 173 80 5 0.0625 0.0289017341040462
REAC REAC:R-HSA-109582 Hemostasis 0.0492607019851339 657 32 6 0.1875 0.0091324200913242
TF TF:M02106 Factor: NF-YA; motif: CRGCCAATCAGNRN 6.21308359209915e-07 1741 43 20 0.465116279069767 0.0114876507754164
TF TF:M02106_1 Factor: NF-YA; motif: CRGCCAATCAGNRN; match class: 1 1.40725394084213e-06 217 29 8 0.275862068965517 0.0368663594470046
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 1.40725394084213e-06 14473 106 102 0.962264150943396 0.00704760588682374
TF TF:M03862_1 Factor: YB-1; motif: NNNNCCAATNN; match class: 1 3.21081354377216e-06 3120 43 24 0.558139534883721 0.00769230769230769
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 3.79701077209801e-06 13929 102 96 0.941176470588235 0.00689209562782684
TF TF:M07302 Factor: NF-Y; motif: RGCCAATCRGN 1.21528035261091e-05 1576 43 17 0.395348837209302 0.0107868020304569
TF TF:M00287 Factor: NF-Y; motif: NNNRRCCAATSRGNNN 1.26303141030634e-05 1635 33 15 0.454545454545455 0.00917431192660551
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 1.29178520691707e-05 14106 106 99 0.933962264150943 0.00701829008932369
TF TF:M10005 Factor: NF-YA; motif: NYRRCCAATCAGAR 1.64228831998568e-05 2225 34 17 0.5 0.00764044943820225
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 1.64228831998568e-05 12351 102 89 0.872549019607843 0.00720589425957412
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 2.56671632809257e-05 14575 106 100 0.943396226415094 0.00686106346483705
TF TF:M03805_1 Factor: YB-1; motif: CCAMTCNGMR; match class: 1 3.07869693650832e-05 3680 43 24 0.558139534883721 0.00652173913043478
TF TF:M02090 Factor: E2F-4; motif: GCGGGAAANA 3.46083298599354e-05 11966 93 80 0.860215053763441 0.00668560922614073
TF TF:M07250 Factor: E2F-1; motif: NNNSSCGCSAANN 3.46083298599354e-05 10703 74 62 0.837837837837838 0.00579276838269644
TF TF:M00778 Factor: AhR; motif: NTNGCGTGNNN 3.46083298599354e-05 3526 67 31 0.462686567164179 0.00879183210436756
TF TF:M00775 Factor: NF-Y; motif: NNNNRRCCAATSR 6.35738913072476e-05 1428 43 15 0.348837209302326 0.0105042016806723
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 8.30939703459486e-05 13270 102 91 0.892156862745098 0.00685757347400151
TF TF:M10006 Factor: NF-YC; motif: NNRRCCAATCAGNR 9.40246249978361e-05 2510 35 17 0.485714285714286 0.00677290836653386
TF TF:M09892 Factor: E2F-1; motif: NNNNGGCGGGAARN 0.000122932703455936 13528 100 90 0.9 0.0066528681253696
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.000130703538746678 14997 114 107 0.93859649122807 0.00713476028539041
TF TF:M00209 Factor: NF-Y; motif: NCTGATTGGYTASY 0.000152640731941401 3776 43 23 0.534883720930233 0.00609110169491525
TF TF:M10006_1 Factor: NF-YC; motif: NNRRCCAATCAGNR; match class: 1 0.000309632491912963 388 29 7 0.241379310344828 0.0180412371134021
TF TF:M04683 Factor: NF-YA; motif: YTCTSATTGGYYRN 0.000309632491912963 1657 43 15 0.348837209302326 0.00905250452625226
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.000309632491912963 14873 106 99 0.933962264150943 0.00665635715726484
TF TF:M07206_1 Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 0.000334335377731054 10849 91 72 0.791208791208791 0.0066365563646419
TF TF:M04823 Factor: E2F-4; motif: NNTTCCCGCCNN 0.000334975691120684 12747 100 86 0.86 0.00674668549462619
TF TF:M11052_1 Factor: Hey2; motif: NNCACGYGNN; match class: 1 0.000334975691120684 9523 112 79 0.705357142857143 0.00829570513493647
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.000351179276057214 9162 100 70 0.7 0.007640253219821
TF TF:M09816 Factor: NFYA; motif: RRCCAATCAGN 0.000385723174710586 1969 43 16 0.372093023255814 0.00812595226003047
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.000427041579188292 8947 113 76 0.672566371681416 0.00849446741924667
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.000427041579188292 13190 102 89 0.872549019607843 0.0067475360121304
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.000508141260426338 10253 68 54 0.794117647058823 0.00526675119477226
TF TF:M11529 Factor: E2F-2; motif: GCGCGCGCNCS 0.000521454998059081 16263 106 103 0.971698113207547 0.00633339482260346
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.000537354726854445 16103 111 107 0.963963963963964 0.00664472458548097
TF TF:M09896 Factor: E2F-7; motif: GRGGCGGGAANNN 0.000537354726854445 9927 100 73 0.73 0.00735368187770726
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.000537354726854445 13022 102 88 0.862745098039216 0.00675779450161266
TF TF:M00425 Factor: E2F; motif: TTTCGCGC 0.000543217262761227 11043 91 72 0.791208791208791 0.006519967400163
TF TF:M02107 Factor: NF-YC; motif: NRGCCAATYAGMGC 0.000576333207719537 1001 33 10 0.303030303030303 0.00999000999000999
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.00059013305711099 11232 70 58 0.828571428571429 0.00516381766381766
TF TF:M00687 Factor: alpha-CP1; motif: CAGCCAATGAG 0.00059013305711099 2326 31 14 0.451612903225806 0.0060189165950129
TF TF:M11066 Factor: HES-7; motif: GNCACGYGNN 0.000712358585340807 11507 109 86 0.788990825688073 0.00747371165377596
TF TF:M11066_1 Factor: HES-7; motif: GNCACGYGNN; match class: 1 0.000810239396503949 8172 112 70 0.625 0.00856583455702398
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.000830993676476824 10640 102 77 0.754901960784314 0.00723684210526316
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.000874679405054868 10233 102 75 0.735294117647059 0.00732922896511287
TF TF:M00287_1 Factor: NF-Y; motif: NNNRRCCAATSRGNNN; match class: 1 0.000936093817806914 184 29 5 0.172413793103448 0.0271739130434783
TF TF:M11058_1 Factor: Hey1; motif: NGCRCGYGYN; match class: 1 0.000943378657564727 10925 117 88 0.752136752136752 0.00805491990846682
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.00110291658532711 13184 114 97 0.850877192982456 0.00735740291262136
TF TF:M04823_1 Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 0.00119253799147119 7850 119 71 0.596638655462185 0.00904458598726115
TF TF:M00516 Factor: E2F-1; motif: TTTSGCGCGMNR 0.00139634885447339 6904 67 41 0.611940298507463 0.00593858632676709
TF TF:M08225_1 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 0.0014555608084307 7993 35 27 0.771428571428571 0.00337795571124734
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.00156468026659003 16228 106 102 0.962264150943396 0.00628543258565442
TF TF:M11535 Factor: E2F-4; motif: TTTTGGCGCCAWWN 0.00156468026659003 10884 79 62 0.784810126582278 0.00569643513414186
TF TF:M11081 Factor: SREBP-1; motif: RTCRCGTGAY 0.00156468026659003 11062 117 88 0.752136752136752 0.00795516181522329
TF TF:M00333_1 Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 0.00156468026659003 12401 106 87 0.820754716981132 0.00701556326102734
TF TF:M00139 Factor: AhR; motif: CCYCNRRSTNGCGTGASA 0.00172674321655946 3728 71 29 0.408450704225352 0.00777896995708155
TF TF:M08457_1 Factor: ER71:SREBP-2; motif: NTSACGTGACGGAARY; match class: 1 0.00172674321655946 5591 53 30 0.566037735849057 0.00536576641030227
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.0019453793499063 4320 101 41 0.405940594059406 0.00949074074074074
TF TF:M07250_1 Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 0.00195954198038778 5515 69 36 0.521739130434783 0.00652765185856754
TF TF:M03805 Factor: YB-1; motif: CCAMTCNGMR 0.00195954198038778 10161 45 37 0.822222222222222 0.00364137388052357
TF TF:M03862 Factor: YB-1; motif: NNNNCCAATNN 0.00195954198038778 9198 99 67 0.676767676767677 0.00728419221569906
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.00204807729523715 15268 109 101 0.926605504587156 0.00661514278228976
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.00208518657685221 10419 109 79 0.724770642201835 0.00758230156444956
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.00210212616577672 16194 102 98 0.96078431372549 0.0060516240582932
TF TF:M00738 Factor: E2F-4:DP-1; motif: TTTSGCGC 0.00236748465385515 9812 70 52 0.742857142857143 0.00529963310232368
TF TF:M11052 Factor: Hey2; motif: NNCACGYGNN 0.00240457115551 12502 109 89 0.81651376146789 0.00711886098224284
TF TF:M08676_1 Factor: C/EBPgamma:Elf-1; motif: TKRCGHAATWSCGGAAGT; match class: 1 0.00246246944187157 2364 31 13 0.419354838709677 0.00549915397631134
TF TF:M07084 Factor: E2F-4; motif: NGGCGGGAARN 0.00246246944187157 10834 100 75 0.75 0.00692265091378992
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.00274376976223036 12302 105 85 0.80952380952381 0.0069094456185986
TF TF:M10635_1 Factor: Nkx2-3; motif: GNCGTTRAG; match class: 1 0.00274376976223036 703 46 9 0.195652173913043 0.0128022759601707
TF TF:M08226_1 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 0.00278444879184964 5604 31 20 0.645161290322581 0.00356887937187723
TF TF:M09636 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG 0.00278444879184964 16244 111 106 0.954954954954955 0.00652548633341541
TF TF:M11075 Factor: Sohlh2; motif: NNCACGTGNN 0.00290200609613249 11927 71 59 0.830985915492958 0.00494675945334116
TF TF:M11601 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.00290200609613249 14823 114 103 0.903508771929825 0.00694866086487216
TF TF:M08207_1 Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 0.00311832165699849 15466 111 103 0.927927927927928 0.00665976981766455
TF TF:M11603 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.00311832165699849 16361 114 109 0.956140350877193 0.00666218446305238
TF TF:M00327_1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 0.00316935358795022 6888 74 43 0.581081081081081 0.00624274099883856
TF TF:M00939 Factor: E2F; motif: TTTSGCGSG 0.00336105545024121 6433 67 38 0.567164179104478 0.00590704181563812
TF TF:M04148 Factor: TFAP2A; motif: NGCCCYNNGGGCN 0.00341049721156861 10040 117 81 0.692307692307692 0.00806772908366534
TF TF:M09817 Factor: PAX5; motif: RNGCGTGACCNN 0.00341049721156861 12511 73 62 0.849315068493151 0.00495563903764687
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.00343731219672668 10230 91 66 0.725274725274725 0.00645161290322581
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.00343731219672668 7728 102 60 0.588235294117647 0.0077639751552795
TF TF:M08457 Factor: ER71:SREBP-2; motif: NTSACGTGACGGAARY 0.00343731219672668 12052 64 54 0.84375 0.00448058413541321
TF TF:M00986 Factor: Churchill; motif: CGGGNN 0.00343731219672668 14197 109 96 0.880733944954128 0.00676199197013454
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.00343731219672668 13611 111 95 0.855855855855856 0.0069796488134597
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.00349101315358647 10281 102 73 0.715686274509804 0.00710047660733392
TF TF:M04636 Factor: TFII-I; motif: NAGGAAGTGN 0.00356390928082044 12845 55 49 0.890909090909091 0.00381471389645777
TF TF:M09816_1 Factor: NFYA; motif: RRCCAATCAGN; match class: 1 0.00356390928082044 278 29 5 0.172413793103448 0.0179856115107914
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.00369615847445869 6334 109 55 0.504587155963303 0.00868329649510578
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.00369615847445869 14096 111 97 0.873873873873874 0.00688138479001135
TF TF:M11058 Factor: Hey1; motif: NGCRCGYGYN 0.00379225243433203 13162 114 95 0.833333333333333 0.00721774806260447
TF TF:M04683_1 Factor: NF-YA; motif: YTCTSATTGGYYRN; match class: 1 0.00403117287957128 185 23 4 0.173913043478261 0.0216216216216216
TF TF:M02090_1 Factor: E2F-4; motif: GCGGGAAANA; match class: 1 0.00440408431782511 6378 109 55 0.504587155963303 0.00862339291313892
TF TF:M11601_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.00471913987270211 11053 117 86 0.735042735042735 0.00778069302451823
TF TF:M04516_1 Factor: E2F-1; motif: TTTGGCGCCAAA; match class: 1 0.00514087009906658 10227 105 74 0.704761904761905 0.00723574850884912
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.00559940304874836 10357 109 77 0.706422018348624 0.00743458530462489
TF TF:M00333 Factor: ZF5; motif: NRNGNGCGCGCWN 0.00634429229793157 15072 102 93 0.911764705882353 0.0061703821656051
TF TF:M00695 Factor: ETF; motif: GVGGMGG 0.00634429229793157 10430 99 71 0.717171717171717 0.00680728667305848
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.00634429229793157 14593 114 101 0.885964912280702 0.00692112656753238
TF TF:M11530_1 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 0.0067359187630667 13449 82 71 0.865853658536585 0.00527920291471485
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.00700239751028915 15260 106 97 0.915094339622642 0.0063564875491481
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.00700842542148238 10494 102 73 0.715686274509804 0.00695635601295979
TF TF:M09994 Factor: Myogenin; motif: NNNCAGCTGYYNN 0.00712340608145392 630 9 4 0.444444444444444 0.00634920634920635
TF TF:M01873_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.00784413594377217 2672 101 28 0.277227722772277 0.0104790419161677
TF TF:M10121 Factor: ZFX; motif: SNAGGCCNCR 0.00784413594377217 3997 102 37 0.362745098039216 0.00925694270703027
TF TF:M01783 Factor: SP2; motif: GGGCGGGAC 0.00805533243765695 9148 41 31 0.75609756097561 0.00338871884564932
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.00812318528559559 9715 109 73 0.669724770642202 0.00751415337107566
TF TF:M04148_1 Factor: TFAP2A; motif: NGCCCYNNGGGCN; match class: 1 0.00827893394667245 9613 117 77 0.658119658119658 0.00800998647664621
TF TF:M01240 Factor: BEN; motif: CAGCGRNV 0.00875668379526541 16498 109 104 0.954128440366973 0.00630379439932113
TF TF:M03976 Factor: ERG; motif: ACCGGAWATCCGGT 0.0093285066599428 12803 32 30 0.9375 0.00234320081230962
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.0117526862763977 8180 99 59 0.595959595959596 0.00721271393643032
TF TF:M11393_1 Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 0.0117526862763977 13665 48 44 0.916666666666667 0.00321990486644713
TF TF:M00427 Factor: E2F; motif: TTTSGCGS 0.0117891504939744 9485 67 47 0.701492537313433 0.00495519240906695
TF TF:M03922 Factor: SP4; motif: NWRGCCACGCCCMCTYN 0.0127748637353488 6046 103 49 0.475728155339806 0.00810453192193186
TF TF:M04710 Factor: CHD2; motif: TCTCGCGAG 0.0132338231185235 14109 94 82 0.872340425531915 0.00581189311786803
TF TF:M07222 Factor: NFYA; motif: AGNSYKCTGATTGGTNNR 0.0133581533494527 714 85 11 0.129411764705882 0.015406162464986
TF TF:M00426 Factor: E2F; motif: TTTSGCGS 0.0136198233572257 11885 91 71 0.78021978021978 0.00597391670172486
TF TF:M00919 Factor: E2F; motif: NCSCGCSAAAN 0.0144007841575922 6149 67 35 0.522388059701492 0.00569198243616848
TF TF:M08224 Factor: Elk-1:Pax-1; motif: ACCGGAACTACGCWTSANTG 0.0144334232552307 8925 31 24 0.774193548387097 0.0026890756302521
TF TF:M00740 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC 0.0144538008437313 10427 69 51 0.739130434782609 0.00489114798120265
TF TF:M08441 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG 0.0152415561845583 16345 99 94 0.94949494949495 0.00575099418782502
TF TF:M00431 Factor: E2F-1; motif: TTTSGCGS 0.0152415561845583 7257 67 39 0.582089552238806 0.00537412153782555
TF TF:M11533 Factor: E2F-1; motif: NTTTTGGCGCCAWWWN 0.0153469160398558 13105 117 95 0.811965811965812 0.00724914154902709
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.0154801043955009 11063 44 36 0.818181818181818 0.00325409021061195
TF TF:M08226 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG 0.0158557193402621 12039 31 28 0.903225806451613 0.00232577456599385
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.0169686968487324 13173 106 87 0.820754716981132 0.00660441812798907
TF TF:M03896_1 Factor: EGR1; motif: NACGCCCACGCANW; match class: 1 0.0169686968487324 2106 101 23 0.227722772277228 0.0109211775878443
TF TF:M11882_1 Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 0.0172652507776623 11423 81 62 0.765432098765432 0.00542764597741399
TF TF:M00425_1 Factor: E2F; motif: TTTCGCGC; match class: 1 0.0172652507776623 5355 68 32 0.470588235294118 0.00597572362278245
TF TF:M04691 Factor: Kaiso; motif: TCTCGCGAG 0.0172652507776623 15113 102 92 0.901960784313726 0.00608747435982267
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.0174685340907394 11728 37 32 0.864864864864865 0.00272851296043656
TF TF:M11018 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN 0.0177850508055665 16955 96 93 0.96875 0.00548510763786494
TF TF:M06376 Factor: ZNF770; motif: KGGGGGCRATS 0.0177850508055665 35 79 3 0.0379746835443038 0.0857142857142857
TF TF:M00346_1 Factor: GATA-1; motif: NCWGATAACA; match class: 1 0.0187759906374088 679 29 6 0.206896551724138 0.00883652430044183
TF TF:M00209_1 Factor: NF-Y; motif: NCTGATTGGYTASY; match class: 1 0.0187826949468981 680 29 6 0.206896551724138 0.00882352941176471
TF TF:M04748_1 Factor: GABP-alpha; motif: AACCGGAAR; match class: 1 0.0189884630118376 10368 78 56 0.717948717948718 0.00540123456790123
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0194205483493897 9106 105 66 0.628571428571429 0.00724796837250165
TF TF:M09817_1 Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 0.0194618116167935 6170 35 21 0.6 0.00340356564019449
TF TF:M10020 Factor: OSR2; motif: NNNNCWGCTNCTGNNG 0.0197243284146561 2584 90 24 0.266666666666667 0.00928792569659443
TF TF:M07356 Factor: HIF2A; motif: ACGTGNNN 0.0200463198150679 1852 43 12 0.27906976744186 0.00647948164146868
TF TF:M03978 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN 0.0211644622004375 12082 114 87 0.763157894736842 0.00720079457043536
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.0212750894756043 8319 23 18 0.782608695652174 0.00216372160115399
TF TF:M01240_1 Factor: BEN; motif: CAGCGRNV; match class: 1 0.0212946198118734 13227 117 95 0.811965811965812 0.00718227867241249
TF TF:M08412_1 Factor: rfx3:SREBP-2; motif: ATGGYAACRTCACGTGAY; match class: 1 0.0212946198118734 4386 79 31 0.392405063291139 0.00706794345645235
TF TF:M04691_1 Factor: Kaiso; motif: TCTCGCGAG; match class: 1 0.0212946198118734 10488 54 41 0.759259259259259 0.00390922959572845
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.0212946198118734 8495 102 61 0.598039215686274 0.00718069452619188
TF TF:M00976 Factor: AhR,; motif: NRCGTGNGN 0.0214685485706584 4351 73 29 0.397260273972603 0.00666513445185015
TF TF:M04710_1 Factor: CHD2; motif: TCTCGCGAG; match class: 1 0.0214685485706584 11477 68 53 0.779411764705882 0.00461793151520432
TF TF:M04168_1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 0.0216836984083189 183 40 4 0.1 0.0218579234972678
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.0217536292154617 8227 103 60 0.58252427184466 0.00729305943843442
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.0217841166566902 11467 110 81 0.736363636363636 0.0070637481468562
TF TF:M10578_1 Factor: Barhl-1; motif: NTAAACGN; match class: 1 0.0218133692584043 1391 28 8 0.285714285714286 0.00575125808770669
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.0218133692584043 10023 56 41 0.732142857142857 0.00409059163922977
TF TF:M00076 Factor: GATA-2; motif: NNNGATRNNN 0.0231790880398301 3216 17 9 0.529411764705882 0.00279850746268657
TF TF:M08878_1 Factor: EGR; motif: CGCCCCCGCNN; match class: 1 0.0233481584908551 3224 101 30 0.297029702970297 0.00930521091811414
TF TF:M03989 Factor: FLI1; motif: ACCGGAAATCCGGT 0.0233626829853361 10442 75 54 0.72 0.00517142309902318
TF TF:M08525 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM 0.023687935384464 17065 109 105 0.963302752293578 0.00615294462349839
TF TF:M03924 Factor: YY1; motif: NNCGCCATTNN 0.0239764399374108 10084 104 70 0.673076923076923 0.00694168980563269
TF TF:M11877_1 Factor: pax-2; motif: NCGTCACGCNYSRNYGCNYN; match class: 1 0.0240203017698649 5304 102 43 0.42156862745098 0.00810708898944193
TF TF:M08232 Factor: Elk-1:TEF; motif: RCCGGAAGTTACGTAAN 0.0242136564058818 6188 9 8 0.888888888888889 0.00129282482223659
TF TF:M10530_1 Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1 0.0242136564058818 3780 47 19 0.404255319148936 0.00502645502645503
TF TF:M01770 Factor: XBP-1; motif: WNNGMCACGTC 0.0246689501931624 11003 63 48 0.761904761904762 0.00436244660547124
TF TF:M11393 Factor: Erg; motif: NACCGGATATCCGGTN 0.0246689501931624 14105 48 44 0.916666666666667 0.00311946118397731
TF TF:M04516 Factor: E2F-1; motif: TTTGGCGCCAAA 0.0248820214521099 11383 105 77 0.733333333333333 0.00676447333743301
TF TF:M12231 Factor: LRF; motif: NCGACCACCGN 0.0264616799356303 11477 41 34 0.829268292682927 0.00296244663239523
TF TF:M08214_1 Factor: Elk-1:ETV7; motif: ANSCGGACGGATDTCCGGNT; match class: 1 0.0271477737910774 2312 11 6 0.545454545454545 0.00259515570934256
TF TF:M08878 Factor: EGR; motif: CGCCCCCGCNN 0.0276692119511052 7483 102 55 0.53921568627451 0.00734999331818789
TF TF:M00920 Factor: E2F; motif: NKCGCGCSAAAN 0.0276692119511052 5663 67 32 0.477611940298507 0.00565071516863853
TF TF:M11976_1 Factor: RFX7; motif: CGTTGCYAY; match class: 1 0.0276692119511052 315 45 5 0.111111111111111 0.0158730158730159
TF TF:M11428 Factor: PEA3; motif: NACCGGAAGTN 0.0278228446435453 7186 36 23 0.638888888888889 0.00320066796548845
TF TF:M10115 Factor: LRF; motif: NRGGGKCKY 0.028119519291688 7623 94 52 0.553191489361702 0.00682146136691591
TF TF:M00918 Factor: E2F; motif: TTTSGCGSG 0.0282904958514766 5575 60 29 0.483333333333333 0.00520179372197309
TF TF:M11082 Factor: SREBP-1; motif: RNCACGCSAY 0.0293789988692788 4292 46 20 0.434782608695652 0.00465983224603914
TF TF:M04934_1 Factor: TR4; motif: ACCCCGS; match class: 1 0.0297455738274392 15478 106 96 0.905660377358491 0.00620235172502907
TF TF:M11427 Factor: PEA3; motif: NACCGGAAGTN 0.0297800444410662 10585 23 20 0.869565217391304 0.00188946622579121
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0298018035758961 5919 99 45 0.454545454545455 0.00760263558033452
TF TF:M02062 Factor: Erg; motif: ACCGGAAGTN 0.0298018035758961 8056 19 15 0.789473684210526 0.00186196623634558
TF TF:M11595_1 Factor: GCMa; motif: RTGCGGGTN; match class: 1 0.0305520029004111 5786 115 50 0.434782608695652 0.00864154856550294
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.0306293334855538 7801 101 56 0.554455445544555 0.00717856685040379
TF TF:M04106_1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 0.0306293334855538 8372 109 63 0.577981651376147 0.00752508361204013
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.0308254473267572 4199 99 35 0.353535353535354 0.00833531793284115
TF TF:M11880_1 Factor: pax-6; motif: NYACGCWTSANYGMNCN; match class: 1 0.0314540615634405 7046 39 24 0.615384615384615 0.00340618790803293
TF TF:M04162 Factor: BHLHE40; motif: NKCACGTGMC 0.0315809985748361 34 111 3 0.027027027027027 0.0882352941176471
TF TF:M12183_1 Factor: KLF14; motif: NRCCACRCCCMCN; match class: 1 0.0316455943037712 2487 115 27 0.234782608695652 0.0108564535585042
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.0321294734304554 7469 103 55 0.533980582524272 0.00736377025036819
TF TF:M11668 Factor: IRF-6; motif: ACCGATACC 0.0321294734304554 406 98 8 0.0816326530612245 0.0197044334975369
TF TF:M08341_1 Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN; match class: 1 0.0330765384904553 1317 110 17 0.154545454545455 0.0129081245254366
TF TF:M03876 Factor: Kaiso; motif: GCMGGGRGCRGS 0.0335710347242877 13622 109 90 0.825688073394495 0.00660695933049479
TF TF:M01200_1 Factor: CTCF; motif: NNNGCCASCAGRKGGCRSNN; match class: 1 0.0360628815395164 554 17 4 0.235294117647059 0.0072202166064982
TF TF:M04168 Factor: CLOCK; motif: AACACGTGTN 0.0360628815395164 225 40 4 0.1 0.0177777777777778
TF TF:M02011 Factor: HES-1; motif: GSCACGMGMC 0.0360628815395164 4259 106 37 0.349056603773585 0.00868748532519371
TF TF:M10098 Factor: DP-1; motif: NRNNGGCGGGAANN 0.0360628815395164 7015 100 51 0.51 0.00727013542409123
TF TF:M09670 Factor: USF2; motif: NGGTCACGTGNNSNNNNNN 0.0368572758329763 2368 64 17 0.265625 0.00717905405405405
TF TF:M12152 Factor: Sp1; motif: NWRGCCACGCCCMCN 0.0368767562486367 7341 103 54 0.524271844660194 0.00735594605639559
TF TF:M09911 Factor: c-Ets-1; motif: NNRCMGGAAGTGG 0.0368767562486367 2495 5 4 0.8 0.00160320641282565
TF TF:M01199 Factor: RNF96; motif: BCCCGCRGCC 0.0368767562486367 8473 22 17 0.772727272727273 0.00200637318541249
TF TF:M08224_1 Factor: Elk-1:Pax-1; motif: ACCGGAACTACGCWTSANTG; match class: 1 0.0368767562486367 2748 29 11 0.379310344827586 0.00400291120815138
TF TF:M04515_1 Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 0.0370579970129377 12173 105 80 0.761904761904762 0.00657192146553849
TF TF:M00655_1 Factor: PEA3; motif: ACWTCCK; match class: 1 0.0370579970129377 2934 7 5 0.714285714285714 0.00170415814587594
TF TF:M08526 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN 0.0370626601851314 16867 106 101 0.952830188679245 0.00598802395209581
TF TF:M10100_1 Factor: TFEA; motif: RGTCACGTGA; match class: 1 0.0370626601851314 2010 115 23 0.2 0.0114427860696517
TF TF:M02059 Factor: ELK-1; motif: ACCGGAAGTN 0.0370626601851314 9423 16 14 0.875 0.00148572641409318
TF TF:M12165 Factor: BTEB2; motif: NCCACRCCCN 0.0370626601851314 4901 116 44 0.379310344827586 0.00897775964088961
TF TF:M09641 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN 0.037188416531196 3222 74 23 0.310810810810811 0.00713842333954066
TF TF:M00244_1 Factor: NGFI-C; motif: WTGCGTGGGYGG; match class: 1 0.0381010054813101 1772 92 18 0.195652173913043 0.0101580135440181
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.0381010054813101 8322 19 15 0.789473684210526 0.00180245133381399
TF TF:M09969 Factor: EKLF; motif: NGGGYGKGGCNNGG 0.0382601006790541 4589 103 38 0.368932038834951 0.00828067117018958
TF TF:M01770_1 Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 0.0383256405489314 4554 42 19 0.452380952380952 0.00417215634606939
TF TF:M08487 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG 0.0394510355369716 13942 54 48 0.888888888888889 0.00344283460048773
TF TF:M08232_1 Factor: Elk-1:TEF; motif: RCCGGAAGTTACGTAAN; match class: 1 0.0394510355369716 1294 34 8 0.235294117647059 0.00618238021638331
TF TF:M11401_1 Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1 0.040645944709223 11801 117 86 0.735042735042735 0.00728751800694856
TF TF:M03812 Factor: arnt; motif: CACGYA 0.0409336387471281 4330 74 28 0.378378378378378 0.00646651270207852
TF TF:M01252 Factor: E2F-6; motif: CNTTTCNT 0.0409336387471281 2516 94 23 0.24468085106383 0.00914149443561208
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0412274781364113 8415 102 59 0.57843137254902 0.00701128936423054
TF TF:M09611 Factor: ER81; motif: NNNGRCMGGAAGYRNNNNNNNS 0.0412274781364113 2666 22 9 0.409090909090909 0.00337584396099025
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 0.0414616451158022 5051 36 18 0.5 0.0035636507622253
TF TF:M00033 Factor: p300; motif: NNNGGGAGTNNNNS 0.0414616451158022 8577 77 47 0.61038961038961 0.00547977148187012
TF TF:M05344 Factor: Egr-2; motif: GCGTGGGCGG 0.0420600511519087 266 91 6 0.0659340659340659 0.0225563909774436
TF TF:M08451_1 Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA; match class: 1 0.0425115211698714 2584 36 12 0.333333333333333 0.00464396284829721
TF TF:M10075 Factor: SREBP-1; motif: NGTSRGGTGAN 0.0425115211698714 4507 17 10 0.588235294117647 0.00221877080097626
TF TF:M02069 Factor: Erm; motif: ACCGGAAGTN 0.0425115211698714 6892 20 14 0.7 0.002031340684852
TF TF:M11883_1 Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 0.0438474364332206 7768 39 25 0.641025641025641 0.0032183316168898
TF TF:M03975 Factor: ERG; motif: ACCGGAARTN 0.0450603354837039 10002 23 19 0.826086956521739 0.0018996200759848
TF TF:M09904 Factor: Elk-1; motif: RCCGGAAGTGN 0.0450603354837039 8164 23 17 0.739130434782609 0.00208231259186673
TF TF:M08313_1 Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 0.0458454690375412 9721 51 36 0.705882352941177 0.00370332270342557
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0458454690375412 7710 102 55 0.53921568627451 0.00713359273670558
TF TF:M11089 Factor: TFEA; motif: NNCATGTGACN 0.0462776858478665 894 6 3 0.5 0.00335570469798658
TF TF:M12145 Factor: Egr-4; motif: NMCGCCCACGCAN 0.0463049617639303 480 91 8 0.0879120879120879 0.0166666666666667
TF TF:M03572 Factor: DEC1; motif: CNCACRTGASC 0.0463049617639303 6713 79 40 0.506329113924051 0.00595858781468792
TF TF:M08568_1 Factor: ER71:E2A; motif: CASSTGNACCGGAWRYN; match class: 1 0.0463049617639303 15133 41 39 0.951219512195122 0.00257714927641578
TF TF:M11018_1 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 0.0468748195448421 15920 106 97 0.915094339622642 0.0060929648241206
TF TF:M07115 Factor: NF-YB; motif: NNNYNRRCCAATCAG 0.0468748195448421 529 33 5 0.151515151515152 0.00945179584120983
TF TF:M06444 Factor: ZNF557; motif: NCCGCKTCCTGC 0.0468748195448421 1344 104 16 0.153846153846154 0.0119047619047619
TF TF:M03895 Factor: CTCF; motif: WGCGCCMYCTAGYGGYN 0.0468748195448421 9251 102 63 0.617647058823529 0.00681007458653119
TF TF:M03929_1 Factor: ZBTB7C; motif: NCGACCACCGNN; match class: 1 0.0468748195448421 303 83 6 0.072289156626506 0.0198019801980198
TF TF:M07042_1 Factor: HES-1; motif: NNCKYGTGNNN; match class: 1 0.0468748195448421 661 67 8 0.119402985074627 0.0121028744326778
TF TF:M02063 Factor: c-ets-1; motif: ACCGGAWGTN 0.0473843898214854 7600 36 23 0.638888888888889 0.00302631578947368
TF TF:M01298 Factor: MECP2; motif: CCGGSNNNANNAWWT 0.0473843898214854 1290 21 6 0.285714285714286 0.00465116279069767
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.0473843898214854 10853 102 71 0.696078431372549 0.00654196996222243
TF TF:M11882 Factor: pax-6; motif: NYACGCNYSANYGMNCN 0.0475419810779663 15490 81 74 0.91358024691358 0.00477727566171724
TF TF:M07052 Factor: NRF-1; motif: GCGCMTGCGCN 0.047987710285447 2130 119 24 0.201680672268908 0.0112676056338028
TF TF:M04679 Factor: USF2; motif: GTCACGTGA 0.0486060614206648 1577 115 19 0.165217391304348 0.0120481927710843
TF TF:M04950 Factor: Egr-1; motif: NGCGTGCGY 0.0490109577161254 10935 73 53 0.726027397260274 0.00484682213077275
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.0492058281440872 6749 42 24 0.571428571428571 0.0035560823825752
TF TF:M04064_1 Factor: Pax-5; motif: NGTCACGCWTSANTGMNY; match class: 1 0.0492058281440872 3538 18 9 0.5 0.00254381006218202
TF TF:M12135_1 Factor: mbnl2; motif: NYGCYTYGCTTN; match class: 1 0.0492058281440872 1097 116 15 0.129310344827586 0.0136736554238833
WP WP:WP4718 Cholesterol metabolism (includes both Bloch and Kandutsch-Russell pathways) 6.42065782651986e-20 47 89 17 0.191011235955056 0.361702127659574
WP WP:WP197 Cholesterol Biosynthesis Pathway 7.10970422144699e-20 15 89 12 0.134831460674157 0.8
WP WP:WP4804 Cholesterol Biosynthesis with Skeletal Dysplasias 1.38231504397921e-07 7 89 5 0.0561797752808989 0.714285714285714
WP WP:WP3613 Photodynamic therapy-induced unfolded protein response 5.42279939185978e-07 29 9 4 0.444444444444444 0.137931034482759
WP WP:WP1982 Sterol Regulatory Element-Binding Proteins (SREBP) signalling 6.27348740921442e-07 73 35 7 0.2 0.0958904109589041
WP WP:WP3963 Mevalonate pathway 5.66492942912125e-06 7 77 4 0.051948051948052 0.571428571428571
WP WP:WP3995 Prion disease pathway 0.000127141320190611 37 9 3 0.333333333333333 0.0810810810810811
WP WP:WP5064 7-oxo-C and 7beta-HC pathways 0.0055289030152509 28 41 3 0.0731707317073171 0.107142857142857
WP WP:WP4724 Omega-9 FA synthesis 0.00644150898881852 16 80 3 0.0375 0.1875
WP WP:WP4545 Oxysterols derived from cholesterol 0.0191580503949868 46 41 3 0.0731707317073171 0.0652173913043478

pEpiTd11 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd11
Possible regulators of activation of pEpiTd11 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.