pEpi22 program activity among Epithelial cells

Activation of pEpi22
pEpi22 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi22 by different cell subtypes
pEpi22 gene program activation among cells of different subtypes (Epithelial cells).

pEpi22 top program genes

Top genes of pEpi22 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi22 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi22
pEpi22 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006658 phosphatidylserine metabolic process 0.0421906294515764 37 33 3 0.0909090909090909 0.0810810810810811
GO:BP GO:0002683 negative regulation of immune system process 0.0432132292794971 420 11 4 0.363636363636364 0.00952380952380952
GO:BP GO:0030301 cholesterol transport 0.0472331685568226 112 121 6 0.0495867768595041 0.0535714285714286
GO:BP GO:0071392 cellular response to estradiol stimulus 0.0484992132845379 38 50 3 0.06 0.0789473684210526
GO:BP GO:0046907 intracellular transport 0.0484992132845379 1767 127 26 0.204724409448819 0.0147142048670062
GO:BP GO:0015918 sterol transport 0.0484992132845379 125 121 6 0.0495867768595041 0.048
GO:CC GO:0031300 intrinsic component of organelle membrane 0.00111661577471082 413 141 14 0.099290780141844 0.0338983050847458
GO:CC GO:0016363 nuclear matrix 0.00173065965729797 110 132 7 0.053030303030303 0.0636363636363636
GO:CC GO:0070062 extracellular exosome 0.00173065965729797 2176 72 22 0.305555555555556 0.0101102941176471
GO:CC GO:1903561 extracellular vesicle 0.00179783467001864 2261 72 22 0.305555555555556 0.00973020787262273
GO:CC GO:0043230 extracellular organelle 0.00179783467001864 2263 72 22 0.305555555555556 0.00972160848431286
GO:CC GO:0005766 primary lysosome 0.00187440890100507 154 48 5 0.104166666666667 0.0324675324675325
GO:CC GO:0031982 vesicle 0.00187440890100507 4055 130 48 0.369230769230769 0.0118372379778052
GO:CC GO:0031301 integral component of organelle membrane 0.00187440890100507 382 141 12 0.0851063829787234 0.031413612565445
GO:CC GO:0034399 nuclear periphery 0.00187440890100507 132 132 7 0.053030303030303 0.053030303030303
GO:CC GO:0042582 azurophil granule 0.00187440890100507 154 48 5 0.104166666666667 0.0324675324675325
GO:CC GO:0012505 endomembrane system 0.00352057002382982 4640 141 55 0.390070921985816 0.0118534482758621
GO:CC GO:0098554 cytoplasmic side of endoplasmic reticulum membrane 0.00551191533504297 16 129 3 0.0232558139534884 0.1875
GO:CC GO:0005783 endoplasmic reticulum 0.00551191533504297 1982 137 29 0.211678832116788 0.0146316851664985
GO:CC GO:0120111 neuron projection cytoplasm 0.00748386023475331 93 62 4 0.0645161290322581 0.043010752688172
GO:CC GO:0005775 vacuolar lumen 0.00748386023475331 174 34 4 0.117647058823529 0.0229885057471264
GO:CC GO:0043202 lysosomal lumen 0.00773556153765164 97 26 3 0.115384615384615 0.0309278350515464
GO:CC GO:0005615 extracellular space 0.010623208657156 3594 72 26 0.361111111111111 0.00723427935447969
GO:CC GO:0031228 intrinsic component of Golgi membrane 0.0119375352052787 67 109 4 0.036697247706422 0.0597014925373134
GO:CC GO:0035578 azurophil granule lumen 0.0119375352052787 91 34 3 0.0882352941176471 0.032967032967033
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0119375352052787 11296 141 103 0.730496453900709 0.00911827195467422
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.0130620141141188 158 129 6 0.0465116279069767 0.0379746835443038
GO:CC GO:0031984 organelle subcompartment 0.013384284777716 1773 65 15 0.230769230769231 0.00846023688663283
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.0156384938436496 166 129 6 0.0465116279069767 0.036144578313253
GO:CC GO:0043229 intracellular organelle 0.0158068732899099 12491 138 108 0.782608695652174 0.00864622528220319
GO:CC GO:0043227 membrane-bounded organelle 0.019451085287727 12858 138 110 0.797101449275362 0.00855498522320734
GO:CC GO:0005794 Golgi apparatus 0.0214837297329202 1623 138 23 0.166666666666667 0.0141712877387554
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.0236801494148355 1122 48 9 0.1875 0.00802139037433155
GO:CC GO:0005789 endoplasmic reticulum membrane 0.0236801494148355 1117 48 9 0.1875 0.00805729632945389
GO:CC GO:0000323 lytic vacuole 0.024071999987796 712 48 7 0.145833333333333 0.0098314606741573
GO:CC GO:0005764 lysosome 0.024071999987796 712 48 7 0.145833333333333 0.0098314606741573
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.024071999987796 1139 48 9 0.1875 0.00790166812993854
GO:CC GO:0098588 bounding membrane of organelle 0.0245006869233241 2158 65 16 0.246153846153846 0.00741427247451344
GO:CC GO:0098562 cytoplasmic side of membrane 0.0245006869233241 194 129 6 0.0465116279069767 0.0309278350515464
GO:CC GO:0090575 RNA polymerase II transcription regulator complex 0.0245006869233241 183 27 3 0.111111111111111 0.0163934426229508
GO:CC GO:0035577 azurophil granule membrane 0.0252006090306381 57 88 3 0.0340909090909091 0.0526315789473684
GO:CC GO:0031090 organelle membrane 0.0289848860339264 3612 129 38 0.294573643410853 0.0105204872646733
GO:CC GO:0016021 integral component of membrane 0.0291847144074259 5711 33 18 0.545454545454545 0.00315181229206794
GO:CC GO:0031410 cytoplasmic vesicle 0.0311852505574731 2424 129 28 0.217054263565891 0.0115511551155116
GO:CC GO:0097708 intracellular vesicle 0.0312369336953918 2428 129 28 0.217054263565891 0.0115321252059308
GO:CC GO:0031224 intrinsic component of membrane 0.0371336007898954 5868 33 18 0.545454545454545 0.00306748466257669
GO:CC GO:0005773 vacuole 0.0371336007898954 810 48 7 0.145833333333333 0.00864197530864197
GO:CC GO:0005925 focal adhesion 0.0406582278481002 420 93 7 0.0752688172043011 0.0166666666666667
GO:CC GO:0030055 cell-substrate junction 0.0432217076531491 427 93 7 0.0752688172043011 0.0163934426229508
GO:CC GO:0010494 cytoplasmic stress granule 0.0445687231855568 75 89 3 0.0337078651685393 0.04
GO:CC GO:0043226 organelle 0.0457588306516462 14008 138 115 0.833333333333333 0.00820959451741862
GO:CC GO:0032838 plasma membrane bounded cell projection cytoplasm 0.0482579064862044 226 62 4 0.0645161290322581 0.0176991150442478
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 0.0482579064862044 128 108 4 0.037037037037037 0.03125
GO:CC GO:0010008 endosome membrane 0.0495677857891185 505 45 5 0.111111111111111 0.0099009900990099
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0499614708188488 885 9 3 0.333333333333333 0.00338983050847458
GO:MF GO:0070491 repressing transcription factor binding 0.0481208112193799 73 138 5 0.036231884057971 0.0684931506849315
GO:MF GO:0042802 identical protein binding 0.0481208112193799 2067 40 12 0.3 0.0058055152394775
GO:MF GO:0005319 lipid transporter activity 0.0481208112193799 167 26 3 0.115384615384615 0.0179640718562874
GO:MF GO:0005080 protein kinase C binding 0.0481208112193799 54 52 3 0.0576923076923077 0.0555555555555556
GO:MF GO:0003682 chromatin binding 0.0481208112193799 571 27 6 0.222222222222222 0.010507880910683
GO:MF GO:0140297 DNA-binding transcription factor binding 0.0482602140769848 391 112 8 0.0714285714285714 0.020460358056266
GO:MF GO:0008238 exopeptidase activity 0.0482602140769848 95 111 4 0.036036036036036 0.0421052631578947
GO:MF GO:0042803 protein homodimerization activity 0.048579630745129 676 39 6 0.153846153846154 0.00887573964497041
MIRNA MIRNA:hsa-miR-205-5p hsa-miR-205-5p 0.0245158941025677 182 65 7 0.107692307692308 0.0384615384615385
MIRNA MIRNA:hsa-miR-146b-3p hsa-miR-146b-3p 0.0398070668168511 56 70 4 0.0571428571428571 0.0714285714285714
MIRNA MIRNA:hsa-miR-218-5p hsa-miR-218-5p 0.0398070668168511 814 134 19 0.141791044776119 0.0233415233415233
MIRNA MIRNA:hsa-miR-4753-5p hsa-miR-4753-5p 0.0398070668168511 108 33 4 0.121212121212121 0.037037037037037
MIRNA MIRNA:hsa-miR-18a-5p hsa-miR-18a-5p 0.0398070668168511 260 65 7 0.107692307692308 0.0269230769230769
MIRNA MIRNA:hsa-miR-518f-3p hsa-miR-518f-3p 0.0456331935324256 16 106 3 0.0283018867924528 0.1875
MIRNA MIRNA:hsa-miR-6730-5p hsa-miR-6730-5p 0.0462383532460836 93 19 3 0.157894736842105 0.032258064516129
TF TF:M05386 Factor: KLF17; motif: NGGGCGG 0.00118103590517351 7900 129 80 0.62015503875969 0.010126582278481
TF TF:M05499 Factor: LKLF; motif: NGGGCGG 0.00118103590517351 7900 129 80 0.62015503875969 0.010126582278481
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.00137475521688154 8227 43 34 0.790697674418605 0.00413273368177951
TF TF:M12152 Factor: Sp1; motif: NWRGCCACGCCCMCN 0.00248513088893659 7341 42 31 0.738095238095238 0.00422285792126413
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0025234410677008 13929 117 104 0.888888888888889 0.00746643693014574
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.00259634174636345 3614 42 21 0.5 0.00581073602656336
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.00259634174636345 10494 143 103 0.72027972027972 0.00981513245664189
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.00259634174636345 4320 80 36 0.45 0.00833333333333333
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.00259634174636345 7557 25 21 0.84 0.00277888050813815
TF TF:M00933_1 Factor: Sp1; motif: CCCCGCCCCN; match class: 1 0.00338180532771335 5166 42 25 0.595238095238095 0.00483933410762679
TF TF:M03922 Factor: SP4; motif: NWRGCCACGCCCMCTYN 0.00345505272688852 6046 42 27 0.642857142857143 0.0044657624875951
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.00345505272688852 7508 80 50 0.625 0.0066595631326585
TF TF:M01219 Factor: SP1:SP3; motif: CCSCCCCCYCC 0.00345505272688852 6812 80 47 0.5875 0.00689958896065766
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.00345505272688852 14106 120 106 0.883333333333333 0.00751453282291224
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.00345505272688852 10640 143 103 0.72027972027972 0.00968045112781955
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.0038685674642369 11467 93 74 0.795698924731183 0.00645330077614023
TF TF:M12158 Factor: KLF15; motif: NCCMCGCCCMCN 0.0038685674642369 11088 82 65 0.792682926829268 0.00586219336219336
TF TF:M03922_1 Factor: SP4; motif: NWRGCCACGCCCMCTYN; match class: 1 0.00403195335458029 2143 50 17 0.34 0.00793280447970135
TF TF:M01593 Factor: Zfx; motif: SNSCAGGCCKCGSCSS 0.00621804556000367 4163 38 20 0.526315789473684 0.00480422772039395
TF TF:M00246_1 Factor: Egr-2; motif: NTGCGTRGGCGK; match class: 1 0.00625232613076672 1603 74 18 0.243243243243243 0.0112289457267623
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.00640040198191116 14096 140 121 0.864285714285714 0.00858399545970488
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.00705270331006671 10281 42 35 0.833333333333333 0.00340433809940667
TF TF:M12156_1 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN; match class: 1 0.0070539241068601 1002 76 14 0.184210526315789 0.0139720558882236
TF TF:M00695 Factor: ETF; motif: GVGGMGG 0.00780432850165217 10430 137 96 0.700729927007299 0.00920421860019175
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.00899650934965854 10419 42 35 0.833333333333333 0.0033592475285536
TF TF:M12155 Factor: Sp2; motif: NTWAGTCCCGCCCMCTT 0.00904011998614112 4591 80 35 0.4375 0.00762361141363537
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.00904011998614112 4623 42 22 0.523809523809524 0.00475881462253948
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.00904011998614112 6334 143 69 0.482517482517482 0.0108935901484054
TF TF:M12153 Factor: Sp3; motif: NGCCACGCCCMCN 0.00904011998614112 6205 29 20 0.689655172413793 0.0032232070910556
TF TF:M09723 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS 0.00904011998614112 10156 121 84 0.694214876033058 0.00827097282394644
TF TF:M00986 Factor: Churchill; motif: CGGGNN 0.00904011998614112 14197 139 120 0.863309352517986 0.00845248996266817
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.00904011998614112 12302 93 76 0.817204301075269 0.00617785725898228
TF TF:M09892 Factor: E2F-1; motif: NNNNGGCGGGAARN 0.00907549601596858 13528 135 113 0.837037037037037 0.00835304553518628
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.00907549601596858 10023 33 28 0.848484848484849 0.00279357477801058
TF TF:M11882_1 Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 0.0097014671411156 11423 121 91 0.752066115702479 0.00796638361201086
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.00974485934721856 3962 42 20 0.476190476190476 0.00504795557799091
TF TF:M03933 Factor: ZNF143; motif: TWCCCAYAATGCAYYG 0.00974485934721856 12 127 3 0.0236220472440945 0.25
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.00994030318705327 14473 140 122 0.871428571428571 0.00842948939404408
TF TF:M04110_1 Factor: RUNX3; motif: NRACCGCANWAACCRCAN; match class: 1 0.00994030318705327 3764 8 7 0.875 0.00185972369819341
TF TF:M07226_1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 0.00994030318705327 3915 69 28 0.405797101449275 0.00715197956577267
TF TF:M07226 Factor: SP1; motif: NCCCCKCCCCC 0.00999366660529953 8292 43 31 0.720930232558139 0.00373854317414375
TF TF:M12151 Factor: Sp1; motif: NWRGCCMCGCCCMCN 0.0109987438608469 6821 42 27 0.642857142857143 0.00395836387626448
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.0109987438608469 6047 115 55 0.478260869565217 0.00909541921614023
TF TF:M04823 Factor: E2F-4; motif: NNTTCCCGCCNN 0.0109987438608469 12747 105 86 0.819047619047619 0.00674668549462619
TF TF:M00665 Factor: Sp3; motif: ASMCTTGGGSRGGG 0.0109987438608469 7729 95 56 0.589473684210526 0.00724543925475482
TF TF:M08487_1 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG; match class: 1 0.0109987438608469 8790 93 60 0.645161290322581 0.0068259385665529
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0109987438608469 7710 42 29 0.69047619047619 0.00376134889753567
TF TF:M12151_1 Factor: Sp1; motif: NWRGCCMCGCCCMCN; match class: 1 0.0109987438608469 2548 58 19 0.327586206896552 0.00745682888540031
TF TF:M07084 Factor: E2F-4; motif: NGGCGGGAARN 0.0114768003758548 10834 39 33 0.846153846153846 0.00304596640206757
TF TF:M02018_1 Factor: HTF4; motif: CASCTGB; match class: 1 0.0114768003758548 2796 10 7 0.7 0.0025035765379113
TF TF:M03831_1 Factor: MRF4; motif: CASCTGC; match class: 1 0.0114768003758548 2796 10 7 0.7 0.0025035765379113
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.0114768003758548 9715 115 77 0.669565217391304 0.00792588780236747
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0120164454423584 10233 117 81 0.692307692307692 0.0079155672823219
TF TF:M04433 Factor: PRRX2; motif: NYAATTAN 0.0121755489328035 3153 5 5 1 0.00158579130986362
TF TF:M00333_1 Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 0.0121755489328035 12401 57 49 0.859649122807018 0.00395129425046367
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.0121755489328035 16194 137 128 0.934306569343066 0.00790416203532172
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.0135717847620519 14997 141 125 0.886524822695035 0.00833500033340001
TF TF:M09723_1 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 0.0136049918036825 6113 42 25 0.595238095238095 0.00408964501881237
TF TF:M12183 Factor: KLF14; motif: NRCCACRCCCMCN 0.0139193638450409 6878 77 43 0.558441558441558 0.00625181738877581
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.0139193638450409 4199 42 20 0.476190476190476 0.00476303881876637
TF TF:M01489_1 Factor: NKX6A; motif: NNNAATTAATTAMYNNG; match class: 1 0.0143603353262241 212 141 8 0.0567375886524823 0.0377358490566038
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.0143603353262241 8495 140 82 0.585714285714286 0.00965273690406121
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0143603353262241 6260 46 27 0.58695652173913 0.00431309904153355
TF TF:M12158_1 Factor: KLF15; motif: NCCMCGCCCMCN; match class: 1 0.0143603353262241 6004 139 63 0.453237410071942 0.0104930046635576
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.0143603353262241 5198 43 23 0.534883720930233 0.00442477876106195
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.0143603353262241 15268 143 128 0.895104895104895 0.00838354728844642
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.0143603353262241 8031 72 45 0.625 0.00560328726186029
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.0148568982249646 7283 43 28 0.651162790697674 0.00384456954551696
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0157689288521822 13611 143 118 0.825174825174825 0.00866945852619205
TF TF:M12313_1 Factor: ZNF460; motif: NNACNCCCCCCNN; match class: 1 0.0159956990379544 2203 93 23 0.247311827956989 0.0104403086699955
TF TF:M00245_1 Factor: Egr-3; motif: NTGCGTGGGCGK; match class: 1 0.0166302422343984 2363 66 19 0.287878787878788 0.00804062632247144
TF TF:M05408 Factor: ZNF438; motif: NAMGAKCGKATTGK 0.0167206965175292 83 126 5 0.0396825396825397 0.0602409638554217
TF TF:M10886 Factor: PRX-2; motif: NYAATTAN 0.0172342935220626 1156 3 3 1 0.00259515570934256
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0173175394179533 9362 117 75 0.641025641025641 0.00801110873744926
TF TF:M04384 Factor: LBX2; motif: NNYAATTANN 0.0173304721711783 3625 5 5 1 0.00137931034482759
TF TF:M09788 Factor: TEAD2; motif: NNACATTCCWNNN 0.0177432567494247 559 5 3 0.6 0.00536672629695885
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.017805843482197 5905 42 24 0.571428571428571 0.00406435224386113
TF TF:M09765_1 Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 0.0183233333440507 3318 42 17 0.404761904761905 0.00512356841470766
TF TF:M10529 Factor: Sp1; motif: RGGGMGGRGSNGGGG 0.0183233333440507 6891 65 37 0.569230769230769 0.00536932230445509
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 0.0183233333440507 14575 135 117 0.866666666666667 0.00802744425385935
TF TF:M10530_1 Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1 0.0183233333440507 3780 58 23 0.396551724137931 0.00608465608465609
TF TF:M09967 Factor: AP-2rep; motif: NGGGGCGGGGC 0.0185287438148018 4023 42 19 0.452380952380952 0.00472284364901815
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.0185287438148018 8180 140 79 0.564285714285714 0.00965770171149144
TF TF:M05331 Factor: Gli2; motif: NTRAAGTAGGGTGGCCC 0.0193245899298071 1921 24 9 0.375 0.00468505986465383
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.019603230065098 3020 46 17 0.369565217391304 0.00562913907284768
TF TF:M09636 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG 0.019603230065098 16244 140 130 0.928571428571429 0.00800295493720758
TF TF:M09896_1 Factor: E2F-7; motif: GRGGCGGGAANNN; match class: 1 0.0205555781563155 4525 101 39 0.386138613861386 0.00861878453038674
TF TF:M01783_1 Factor: SP2; motif: GGGCGGGAC; match class: 1 0.0214256418558257 4333 46 21 0.456521739130435 0.00484652665589661
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.0222676209932552 15260 58 55 0.948275862068966 0.00360419397116645
TF TF:M04950 Factor: Egr-1; motif: NGCGTGCGY 0.0227251279476528 10935 43 35 0.813953488372093 0.00320073159579332
TF TF:M03893 Factor: WT1; motif: GNGGGGGCGGGG 0.0248131220446228 8290 42 29 0.69047619047619 0.00349819059107358
TF TF:M09832 Factor: RFX1; motif: NGTTGCCATGG 0.0248131220446228 2370 25 10 0.4 0.00421940928270042
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0249268866240573 4149 42 19 0.452380952380952 0.00457941672692215
TF TF:M12166 Factor: CPBP; motif: NGCCACGCCCN 0.0249268866240573 1328 42 10 0.238095238095238 0.00753012048192771
TF TF:M02036 Factor: WT1; motif: CGCCCCCNCN 0.0250066753983341 9767 80 55 0.6875 0.00563120712603665
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.0251755563250794 10357 139 93 0.669064748201439 0.0089794341990924
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.0251755563250794 13173 117 95 0.811965811965812 0.00721172094435588
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.025729749334229 10853 42 34 0.80952380952381 0.00313277434810651
TF TF:M05432 Factor: ZSCAN18; motif: TRRCGRCGNMCC 0.0262500301145162 4117 66 26 0.393939393939394 0.00631527811513238
TF TF:M10435_1 Factor: Sp2; motif: GGGGCGGGG; match class: 1 0.0262500301145162 3495 42 17 0.404761904761905 0.00486409155937053
TF TF:M01973_1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 0.0262500301145162 2398 143 32 0.223776223776224 0.0133444537114262
TF TF:M01972 Factor: EGR-1; motif: TGCGTGGGCGK 0.0262500301145162 5360 20 13 0.65 0.00242537313432836
TF TF:M09972 Factor: BTEB2; motif: WGGGTGKGGCNGGN 0.0262500301145162 9217 63 43 0.682539682539683 0.00466529239448845
TF TF:M04810 Factor: USF2; motif: AAGTCACG 0.0262500301145162 5496 138 57 0.41304347826087 0.0103711790393013
TF TF:M08993_1 Factor: ZNF777; motif: GTCCGYCCCGTCSAACAAT; match class: 1 0.0262500301145162 4112 123 42 0.341463414634146 0.0102140077821012
TF TF:M12152_1 Factor: Sp1; motif: NWRGCCACGCCCMCN; match class: 1 0.0262500301145162 2859 50 17 0.34 0.00594613501224204
TF TF:M09895 Factor: E2F-6; motif: NGGGCGGGARRNN 0.0262500301145162 7765 35 24 0.685714285714286 0.00309079201545396
TF TF:M00510 Factor: Lhx3a; motif: AWTTAATTAA 0.0262500301145162 201 63 5 0.0793650793650794 0.0248756218905473
TF TF:M07063_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0262500301145162 3495 42 17 0.404761904761905 0.00486409155937053
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.0264463100126747 7469 42 27 0.642857142857143 0.00361494175927166
TF TF:M01303 Factor: SP1; motif: GGGGYGGGGNS 0.0272269750787418 7898 31 22 0.709677419354839 0.00278551532033426
TF TF:M10134_1 Factor: FPM315; motif: GGGAGGAGGRRGRGGRGGRR; match class: 1 0.0272746648419798 585 6 3 0.5 0.00512820512820513
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0274981692662381 8415 42 29 0.69047619047619 0.00344622697563874
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 0.0276283203106885 562 24 5 0.208333333333333 0.00889679715302491
TF TF:M01971_1 Factor: LHX3b; motif: AATTAATTWN; match class: 1 0.0283639267995744 256 141 8 0.0567375886524823 0.03125
TF TF:M12153_1 Factor: Sp3; motif: NGCCACGCCCMCN; match class: 1 0.0284217665003657 1938 42 12 0.285714285714286 0.00619195046439629
TF TF:M00915 Factor: AP-2; motif: SNNNCCNCAGGCN 0.0304988153847061 9612 75 51 0.68 0.00530586766541823
TF TF:M11073_1 Factor: DEC1; motif: GTCACGTGAC; match class: 1 0.0306674428225546 5291 135 54 0.4 0.0102060102060102
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.0321001784879863 14873 143 124 0.867132867132867 0.00833725542930142
TF TF:M11883_1 Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 0.0322793541510935 7768 53 33 0.622641509433962 0.00424819773429454
TF TF:M05361_1 Factor: Sp6; motif: WGGGCGG; match class: 1 0.032496208195853 3313 135 38 0.281481481481481 0.0114699667974645
TF TF:M05332_1 Factor: Sp2; motif: WGGGCGG; match class: 1 0.032496208195853 3313 135 38 0.281481481481481 0.0114699667974645
TF TF:M05444_1 Factor: CPBP; motif: NGGGCGG; match class: 1 0.032496208195853 3313 135 38 0.281481481481481 0.0114699667974645
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.032496208195853 16103 143 131 0.916083916083916 0.00813513009998137
TF TF:M10008 Factor: CSX; motif: NKRAGWGS 0.0343434022935789 10145 114 76 0.666666666666667 0.0074913750616067
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.034547566730259 5919 42 23 0.547619047619048 0.00388579151883764
TF TF:M01122_1 Factor: ZNF219; motif: CRCCCCCCNCCC; match class: 1 0.034547566730259 27 129 3 0.0232558139534884 0.111111111111111
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.034547566730259 10055 42 32 0.761904761904762 0.00318249627051218
TF TF:M08835 Factor: ZNF515; motif: WNSCCCCCWGCNG 0.034547566730259 3537 43 17 0.395348837209302 0.00480633305060786
TF TF:M09732_1 Factor: RFX3; motif: NYNCCMTGGCAACM; match class: 1 0.0346413284554067 982 23 6 0.260869565217391 0.00610997963340122
TF TF:M07409_1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 1 0.0354540448583731 1829 46 12 0.260869565217391 0.00656096227446692
TF TF:M10026 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN 0.0354540448583731 8389 41 28 0.682926829268293 0.00333770413636905
TF TF:M12230_1 Factor: LRF; motif: RCGACCACCNN; match class: 1 0.0354540448583731 2637 61 18 0.295081967213115 0.0068259385665529
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.0354540448583731 10253 120 80 0.666666666666667 0.00780259436262557
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0360575008126732 6807 42 25 0.595238095238095 0.0036726898780667
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.0384309123700622 3783 70 25 0.357142857142857 0.00660851176315094
TF TF:M12160 Factor: KLF15; motif: RCCMCRCCCMCN 0.0386298897772836 12729 140 108 0.771428571428571 0.00848456280933302
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0386298897772836 7728 42 27 0.642857142857143 0.00349378881987578
TF TF:M07129_1 Factor: Sp2; motif: GYCCCGCCYCYNNNN; match class: 1 0.0388410774556813 2422 51 15 0.294117647058824 0.00619322873658134
TF TF:M12185_1 Factor: BTEB4; motif: RCCACGCCCC; match class: 1 0.0397959088706415 334 118 8 0.0677966101694915 0.0239520958083832
TF TF:M08819_1 Factor: LKLF; motif: CNCCACCCS; match class: 1 0.0397959088706415 1532 120 20 0.166666666666667 0.0130548302872063
TF TF:M00075_1 Factor: GATA-1; motif: SNNGATNNNN; match class: 1 0.0403806655012631 1673 15 6 0.4 0.00358637178720861
TF TF:M09732 Factor: RFX3; motif: NYNCCMTGGCAACM 0.0403806655012631 5207 24 14 0.583333333333333 0.00268868830420588
TF TF:M03914 Factor: KLF16; motif: GMCACGCCCCC 0.0403806655012631 3363 42 16 0.380952380952381 0.0047576568539994
TF TF:M04324 Factor: GBX2; motif: NNYAATTANN 0.0413662295466702 3485 4 4 1 0.00114777618364419
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.0430642770428641 8944 43 30 0.697674418604651 0.00335420393559928
TF TF:M04953 Factor: Sp1; motif: GGNDGGRGGCGGGG 0.0430642770428641 8688 66 42 0.636363636363636 0.00483425414364641
TF TF:M09734 Factor: ZNF692; motif: SYNGGSCCCASCCNC 0.0430642770428641 11678 41 34 0.829268292682927 0.0029114574413427
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0430642770428641 16384 143 132 0.923076923076923 0.008056640625
TF TF:M00982 Factor: KROX; motif: CCCGCCCCCRCCCC 0.0430642770428641 7815 93 52 0.559139784946237 0.00665387076135637
TF TF:M09868 Factor: ATF-3; motif: GGTSACGTGAN 0.0430642770428641 6391 129 59 0.457364341085271 0.00923173212329839
TF TF:M12315 Factor: ZF5; motif: RTGCGCGTGCACGYGN 0.0435740260905499 184 83 5 0.0602409638554217 0.0271739130434783
TF TF:M07405 Factor: SREBP-1; motif: RTCACCCCAY 0.0439385577912633 6972 44 26 0.590909090909091 0.00372920252438325
TF TF:M08232_1 Factor: Elk-1:TEF; motif: RCCGGAAGTTACGTAAN; match class: 1 0.0439385577912633 1294 75 13 0.173333333333333 0.0100463678516229
TF TF:M10894 Factor: PMX2B; motif: NYAATTAS 0.0453062522730205 2080 3 3 1 0.00144230769230769
TF TF:M10893 Factor: PMX2B; motif: NCAATTAN 0.0453062522730205 2080 3 3 1 0.00144230769230769
TF TF:M09971 Factor: GKLF; motif: WGGGYGKGGC 0.0453062522730205 5546 43 22 0.511627906976744 0.00396682293544897
TF TF:M12148 Factor: SP8; motif: NCCACGCCCMCN 0.0453062522730205 2907 20 9 0.45 0.00309597523219814
TF TF:M10884 Factor: PRX-2; motif: NCAATTAN 0.0453062522730205 2080 3 3 1 0.00144230769230769
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.0453107739609376 11232 120 85 0.708333333333333 0.00756766381766382
TF TF:M10100 Factor: TFEA; motif: RGTCACGTGA 0.046717843428879 6114 135 59 0.437037037037037 0.00964998364409552
TF TF:M07040_1 Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 0.047109787087405 8156 28 20 0.714285714285714 0.00245218244237371
TF TF:M01105 Factor: ZBRK1; motif: GGGSMGCAGNNNTTT 0.0471554360897377 310 76 6 0.0789473684210526 0.0193548387096774
TF TF:M08780 Factor: Oct3; motif: MWTATGYWAATNN 0.0473851862349236 103 41 3 0.0731707317073171 0.029126213592233
TF TF:M00737_1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 0.0473851862349236 2933 81 23 0.283950617283951 0.0078418002045687
TF TF:M10121 Factor: ZFX; motif: SNAGGCCNCR 0.0473851862349236 3997 37 16 0.432432432432432 0.00400300225168877
TF TF:M11081 Factor: SREBP-1; motif: RTCRCGTGAY 0.0482412392244803 11062 84 61 0.726190476190476 0.00551437353100705
TF TF:M00800_1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 0.0489009853011343 4268 29 14 0.482758620689655 0.00328022492970947
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.049292121194259 13184 80 66 0.825 0.00500606796116505
TF TF:M01744 Factor: REX1; motif: AANATGGCKGCN 0.049292121194259 628 39 6 0.153846153846154 0.00955414012738853
TF TF:M09973_1 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 0.04960042623509 6607 42 24 0.571428571428571 0.00363251097321023

pEpi22 transcription factor target enrichment of top program genes

TF enrichment of pEpi22
Possible regulators of activation of pEpi22 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.