pS11 program activity among Stromal cells

Activation of pS11
pS11 gene program activation in Stromal cells.
Gene program activation of pS11 by different cell subtypes
pS11 gene program activation among cells of different subtypes (Stromal cells).

pS11 top program genes

Top genes of pS11 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS11 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS11
pS11 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0072677 eosinophil migration 2.75322429712634e-05 23 60 5 0.0833333333333333 0.217391304347826
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.000132856091225672 329 75 11 0.146666666666667 0.033434650455927
GO:BP GO:0048245 eosinophil chemotaxis 0.000136369797434948 19 11 3 0.272727272727273 0.157894736842105
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.000160397557303686 215 75 9 0.12 0.0418604651162791
GO:BP GO:0010976 positive regulation of neuron projection development 0.000266026892867854 165 81 8 0.0987654320987654 0.0484848484848485
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.000266026892867854 309 75 10 0.133333333333333 0.0323624595469256
GO:BP GO:0043410 positive regulation of MAPK cascade 0.000266026892867854 539 81 13 0.160493827160494 0.0241187384044527
GO:BP GO:0043062 extracellular structure organization 0.000308913933422204 402 63 10 0.158730158730159 0.0248756218905473
GO:BP GO:0045229 external encapsulating structure organization 0.000308913933422204 404 63 10 0.158730158730159 0.0247524752475248
GO:BP GO:0030198 extracellular matrix organization 0.000308913933422204 401 63 10 0.158730158730159 0.0249376558603491
GO:BP GO:0001763 morphogenesis of a branching structure 0.000594064917152446 195 81 8 0.0987654320987654 0.041025641025641
GO:BP GO:0043408 regulation of MAPK cascade 0.00083111872568764 730 81 14 0.172839506172839 0.0191780821917808
GO:BP GO:0034375 high-density lipoprotein particle remodeling 0.000947781257508656 18 34 3 0.0882352941176471 0.166666666666667
GO:BP GO:0048566 embryonic digestive tract development 0.000963270124840078 31 68 4 0.0588235294117647 0.129032258064516
GO:BP GO:0048247 lymphocyte chemotaxis 0.00102872671240211 63 11 3 0.272727272727273 0.0476190476190476
GO:BP GO:0010875 positive regulation of cholesterol efflux 0.00102872671240211 20 34 3 0.0882352941176471 0.15
GO:BP GO:0033344 cholesterol efflux 0.00102872671240211 66 34 4 0.117647058823529 0.0606060606060606
GO:BP GO:0002548 monocyte chemotaxis 0.0010408189813256 67 73 5 0.0684931506849315 0.0746268656716418
GO:BP GO:0032371 regulation of sterol transport 0.00121526553082814 72 34 4 0.117647058823529 0.0555555555555556
GO:BP GO:0032374 regulation of cholesterol transport 0.00121526553082814 72 34 4 0.117647058823529 0.0555555555555556
GO:BP GO:0045087 innate immune response 0.00121526553082814 998 11 6 0.545454545454545 0.00601202404809619
GO:BP GO:0008360 regulation of cell shape 0.00143171059897691 154 61 6 0.0983606557377049 0.038961038961039
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.00143171059897691 1042 81 16 0.197530864197531 0.0153550863723608
GO:BP GO:0000165 MAPK cascade 0.00154868252953685 935 81 15 0.185185185185185 0.0160427807486631
GO:BP GO:0030162 regulation of proteolysis 0.00161543053952879 752 39 9 0.230769230769231 0.011968085106383
GO:BP GO:0002376 immune system process 0.00161543053952879 3278 22 13 0.590909090909091 0.00396583282489323
GO:BP GO:0070098 chemokine-mediated signaling pathway 0.00161543053952879 87 11 3 0.272727272727273 0.0344827586206897
GO:BP GO:0022610 biological adhesion 0.00161543053952879 1499 67 17 0.253731343283582 0.0113408939292862
GO:BP GO:0040011 locomotion 0.00161543053952879 2028 81 23 0.283950617283951 0.0113412228796844
GO:BP GO:0071363 cellular response to growth factor stimulus 0.00161543053952879 731 81 13 0.160493827160494 0.0177838577291382
GO:BP GO:0032373 positive regulation of sterol transport 0.00161543053952879 30 34 3 0.0882352941176471 0.1
GO:BP GO:0061138 morphogenesis of a branching epithelium 0.00161543053952879 181 81 7 0.0864197530864197 0.0386740331491713
GO:BP GO:0007155 cell adhesion 0.00161543053952879 1492 67 17 0.253731343283582 0.0113941018766756
GO:BP GO:1990868 response to chemokine 0.00161543053952879 97 11 3 0.272727272727273 0.0309278350515464
GO:BP GO:1990869 cellular response to chemokine 0.00161543053952879 97 11 3 0.272727272727273 0.0309278350515464
GO:BP GO:0072073 kidney epithelium development 0.00161543053952879 137 73 6 0.0821917808219178 0.0437956204379562
GO:BP GO:0006954 inflammatory response 0.00161543053952879 794 64 12 0.1875 0.0151133501259446
GO:BP GO:0032376 positive regulation of cholesterol transport 0.00161543053952879 30 34 3 0.0882352941176471 0.1
GO:BP GO:0072164 mesonephric tubule development 0.00161650352398203 93 73 5 0.0684931506849315 0.0537634408602151
GO:BP GO:0070848 response to growth factor 0.00161650352398203 759 81 13 0.160493827160494 0.0171277997364954
GO:BP GO:0010975 regulation of neuron projection development 0.00161650352398203 451 81 10 0.123456790123457 0.0221729490022173
GO:BP GO:0001657 ureteric bud development 0.00161650352398203 92 73 5 0.0684931506849315 0.0543478260869565
GO:BP GO:0098542 defense response to other organism 0.00161650352398203 1218 11 6 0.545454545454545 0.00492610837438424
GO:BP GO:0042330 taxis 0.00161650352398203 656 81 12 0.148148148148148 0.0182926829268293
GO:BP GO:0065008 regulation of biological quality 0.00161650352398203 4131 54 26 0.481481481481481 0.00629387557492133
GO:BP GO:0050900 leukocyte migration 0.00161650352398203 511 73 10 0.136986301369863 0.0195694716242661
GO:BP GO:0030593 neutrophil chemotaxis 0.00161650352398203 103 11 3 0.272727272727273 0.029126213592233
GO:BP GO:0034367 protein-containing complex remodeling 0.00161650352398203 35 34 3 0.0882352941176471 0.0857142857142857
GO:BP GO:0034369 plasma lipoprotein particle remodeling 0.00161650352398203 33 34 3 0.0882352941176471 0.0909090909090909
GO:BP GO:0006935 chemotaxis 0.00161650352398203 653 81 12 0.148148148148148 0.0183767228177642
GO:BP GO:0034368 protein-lipid complex remodeling 0.00161650352398203 33 34 3 0.0882352941176471 0.0909090909090909
GO:BP GO:0048754 branching morphogenesis of an epithelial tube 0.00161650352398203 151 75 6 0.08 0.0397350993377483
GO:BP GO:0072163 mesonephric epithelium development 0.00161650352398203 93 73 5 0.0684931506849315 0.0537634408602151
GO:BP GO:0048870 cell motility 0.00161650352398203 1828 75 20 0.266666666666667 0.0109409190371991
GO:BP GO:0031346 positive regulation of cell projection organization 0.00161650352398203 359 81 9 0.111111111111111 0.0250696378830084
GO:BP GO:0006955 immune response 0.00161650352398203 2311 22 11 0.5 0.00475984422327997
GO:BP GO:0051674 localization of cell 0.00161650352398203 1828 75 20 0.266666666666667 0.0109409190371991
GO:BP GO:0016477 cell migration 0.00161650352398203 1649 81 20 0.246913580246914 0.0121285627653123
GO:BP GO:0048518 positive regulation of biological process 0.00161650352398203 6363 78 45 0.576923076923077 0.00707213578500707
GO:BP GO:0097530 granulocyte migration 0.00161650352398203 151 21 4 0.19047619047619 0.0264900662251656
GO:BP GO:0072676 lymphocyte migration 0.00174198628391178 117 11 3 0.272727272727273 0.0256410256410256
GO:BP GO:1902531 regulation of intracellular signal transduction 0.00174198628391178 1842 81 21 0.259259259259259 0.011400651465798
GO:BP GO:0001823 mesonephros development 0.00180695166244057 97 73 5 0.0684931506849315 0.0515463917525773
GO:BP GO:1990266 neutrophil migration 0.00197579259518024 124 11 3 0.272727272727273 0.0241935483870968
GO:BP GO:0071621 granulocyte chemotaxis 0.00204049279236132 126 11 3 0.272727272727273 0.0238095238095238
GO:BP GO:0060560 developmental growth involved in morphogenesis 0.00207130427817848 236 75 7 0.0933333333333333 0.0296610169491525
GO:BP GO:0060425 lung morphogenesis 0.00207130427817848 50 75 4 0.0533333333333333 0.08
GO:BP GO:0030301 cholesterol transport 0.00208524681721694 112 34 4 0.117647058823529 0.0357142857142857
GO:BP GO:0006874 cellular calcium ion homeostasis 0.00229152263591859 460 4 3 0.75 0.00652173913043478
GO:BP GO:0055074 calcium ion homeostasis 0.00244036492503536 472 4 3 0.75 0.00635593220338983
GO:BP GO:0060326 cell chemotaxis 0.0025518393647048 310 81 8 0.0987654320987654 0.0258064516129032
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.00272151121359705 497 4 3 0.75 0.00603621730382294
GO:BP GO:0030324 lung development 0.00272151121359705 173 75 6 0.08 0.0346820809248555
GO:BP GO:0015918 sterol transport 0.00282446029772145 125 34 4 0.117647058823529 0.032
GO:BP GO:0010874 regulation of cholesterol efflux 0.00283490872625291 46 34 3 0.0882352941176471 0.0652173913043478
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.00290209651116249 516 4 3 0.75 0.00581395348837209
GO:BP GO:0030323 respiratory tube development 0.00293296917588368 177 75 6 0.08 0.0338983050847458
GO:BP GO:0002576 platelet degranulation 0.00299865407228302 126 36 4 0.111111111111111 0.0317460317460317
GO:BP GO:0097529 myeloid leukocyte migration 0.00299865407228302 221 21 4 0.19047619047619 0.0180995475113122
GO:BP GO:0042592 homeostatic process 0.00301236981682052 1981 53 16 0.30188679245283 0.00807672892478546
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.00323033153578401 1160 54 12 0.222222222222222 0.0103448275862069
GO:BP GO:0019935 cyclic-nucleotide-mediated signaling 0.00323033153578401 95 49 4 0.0816326530612245 0.0421052631578947
GO:BP GO:0006875 cellular metal ion homeostasis 0.00323033153578401 593 25 6 0.24 0.0101180438448567
GO:BP GO:0071827 plasma lipoprotein particle organization 0.00323033153578401 52 34 3 0.0882352941176471 0.0576923076923077
GO:BP GO:0097435 supramolecular fiber organization 0.00349547248267258 734 21 6 0.285714285714286 0.00817438692098093
GO:BP GO:0071346 cellular response to interferon-gamma 0.00349547248267258 175 11 3 0.272727272727273 0.0171428571428571
GO:BP GO:0051707 response to other organism 0.00352851292178071 1592 11 6 0.545454545454545 0.00376884422110553
GO:BP GO:0043207 response to external biotic stimulus 0.00352851292178071 1594 11 6 0.545454545454545 0.00376411543287327
GO:BP GO:0035295 tube development 0.00361740540840186 1146 81 15 0.185185185185185 0.0130890052356021
GO:BP GO:0071825 protein-lipid complex subunit organization 0.00372567272073735 56 34 3 0.0882352941176471 0.0535714285714286
GO:BP GO:0031344 regulation of cell projection organization 0.00372567272073735 656 81 11 0.135802469135802 0.0167682926829268
GO:BP GO:0009607 response to biotic stimulus 0.00379789589676133 1626 11 6 0.545454545454545 0.003690036900369
GO:BP GO:0071347 cellular response to interleukin-1 0.0038057767272882 185 11 3 0.272727272727273 0.0162162162162162
GO:BP GO:0021884 forebrain neuron development 0.00393277326662357 27 73 3 0.0410958904109589 0.111111111111111
GO:BP GO:0048584 positive regulation of response to stimulus 0.00393277326662357 2344 81 23 0.283950617283951 0.0098122866894198
GO:BP GO:0060541 respiratory system development 0.00395102202323804 199 75 6 0.08 0.0301507537688442
GO:BP GO:0071674 mononuclear cell migration 0.00396616975639975 191 11 3 0.272727272727273 0.0157068062827225
GO:BP GO:0009605 response to external stimulus 0.00396616975639975 2944 54 20 0.37037037037037 0.00679347826086957
GO:BP GO:0006952 defense response 0.00404062609468332 1818 14 7 0.5 0.00385038503850385
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.00404209937513331 1037 81 14 0.172839506172839 0.0135004821600771
GO:BP GO:0002009 morphogenesis of an epithelium 0.00407166621470334 560 81 10 0.123456790123457 0.0178571428571429
GO:BP GO:0034341 response to interferon-gamma 0.00407166621470334 196 11 3 0.272727272727273 0.0153061224489796
GO:BP GO:0055065 metal ion homeostasis 0.00407166621470334 667 4 3 0.75 0.00449775112443778
GO:BP GO:0043949 regulation of cAMP-mediated signaling 0.00411364321580807 42 49 3 0.0612244897959184 0.0714285714285714
GO:BP GO:0030003 cellular cation homeostasis 0.00411364321580807 673 4 3 0.75 0.00445765230312036
GO:BP GO:0002685 regulation of leukocyte migration 0.00424857836476975 211 73 6 0.0821917808219178 0.028436018957346
GO:BP GO:0006873 cellular ion homeostasis 0.00429804814446653 687 4 3 0.75 0.00436681222707424
GO:BP GO:0051336 regulation of hydrolase activity 0.00429804814446653 1321 81 16 0.197530864197531 0.012112036336109
GO:BP GO:0060441 epithelial tube branching involved in lung morphogenesis 0.00455335604046603 29 75 3 0.04 0.103448275862069
GO:BP GO:0051346 negative regulation of hydrolase activity 0.00481977344562916 470 81 9 0.111111111111111 0.0191489361702128
GO:BP GO:0070555 response to interleukin-1 0.00493236106990588 215 11 3 0.272727272727273 0.013953488372093
GO:BP GO:0032368 regulation of lipid transport 0.00502644633826464 167 34 4 0.117647058823529 0.0239520958083832
GO:BP GO:0009719 response to endogenous stimulus 0.00518743680951504 1683 79 18 0.227848101265823 0.0106951871657754
GO:BP GO:0055080 cation homeostasis 0.00521120692243582 750 4 3 0.75 0.004
GO:BP GO:0035239 tube morphogenesis 0.00532247628961878 950 81 13 0.160493827160494 0.0136842105263158
GO:BP GO:0098771 inorganic ion homeostasis 0.00532247628961878 761 4 3 0.75 0.00394218134034166
GO:BP GO:0050793 regulation of developmental process 0.00540339154894824 2605 76 23 0.302631578947368 0.00882917466410749
GO:BP GO:0001906 cell killing 0.00542901863958652 175 14 3 0.214285714285714 0.0171428571428571
GO:BP GO:0030595 leukocyte chemotaxis 0.00542901863958652 227 11 3 0.272727272727273 0.013215859030837
GO:BP GO:0035556 intracellular signal transduction 0.00559924813232846 2772 81 25 0.308641975308642 0.00901875901875902
GO:BP GO:0048514 blood vessel morphogenesis 0.00561258964821617 711 81 11 0.135802469135802 0.0154711673699015
GO:BP GO:0006928 movement of cell or subcellular component 0.00562755267571747 2311 75 21 0.28 0.00908697533535266
GO:BP GO:0050801 ion homeostasis 0.00576984126520417 808 4 3 0.75 0.00371287128712871
GO:BP GO:0002682 regulation of immune system process 0.00578652530000442 1617 38 11 0.289473684210526 0.00680272108843537
GO:BP GO:0019725 cellular homeostasis 0.00586540917241121 981 26 7 0.269230769230769 0.00713557594291539
GO:BP GO:0044344 cellular response to fibroblast growth factor stimulus 0.00590681133025381 147 75 5 0.0666666666666667 0.0340136054421769
GO:BP GO:0007596 blood coagulation 0.00593441562071952 347 8 3 0.375 0.00864553314121038
GO:BP GO:0007599 hemostasis 0.00606137303515593 351 8 3 0.375 0.00854700854700855
GO:BP GO:0055082 cellular chemical homeostasis 0.00608047846302159 841 4 3 0.75 0.00356718192627824
GO:BP GO:0050817 coagulation 0.00608047846302159 354 8 3 0.375 0.00847457627118644
GO:BP GO:0048699 generation of neurons 0.00616626223074612 1559 73 16 0.219178082191781 0.0102629890955741
GO:BP GO:0001525 angiogenesis 0.00638498599502569 617 81 10 0.123456790123457 0.0162074554294976
GO:BP GO:0060562 epithelial tube morphogenesis 0.0064284125204131 329 75 7 0.0933333333333333 0.0212765957446809
GO:BP GO:0030182 neuron differentiation 0.00650888763262523 1412 73 15 0.205479452054795 0.0106232294617564
GO:BP GO:0071774 response to fibroblast growth factor 0.00650888763262523 153 75 5 0.0666666666666667 0.0326797385620915
GO:BP GO:0006508 proteolysis 0.00674475603419973 1836 8 5 0.625 0.00272331154684096
GO:BP GO:0008584 male gonad development 0.00713967268681109 142 20 3 0.15 0.0211267605633803
GO:BP GO:0046546 development of primary male sexual characteristics 0.00724589216747025 143 20 3 0.15 0.020979020979021
GO:BP GO:0048878 chemical homeostasis 0.00743577258041687 1229 51 11 0.215686274509804 0.00895036615134255
GO:BP GO:0048286 lung alveolus development 0.00748232088798434 42 68 3 0.0441176470588235 0.0714285714285714
GO:BP GO:1905952 regulation of lipid localization 0.00748232088798434 201 34 4 0.117647058823529 0.0199004975124378
GO:BP GO:0031175 neuron projection development 0.00748232088798434 1012 81 13 0.160493827160494 0.0128458498023715
GO:BP GO:0031667 response to nutrient levels 0.00759759651818982 482 54 7 0.12962962962963 0.0145228215767635
GO:BP GO:0120035 regulation of plasma membrane bounded cell projection organization 0.00759759651818982 638 81 10 0.123456790123457 0.0156739811912226
GO:BP GO:0051129 negative regulation of cellular component organization 0.00759759651818982 759 81 11 0.135802469135802 0.0144927536231884
GO:BP GO:0007267 cell-cell signaling 0.00765930883702828 1722 62 15 0.241935483870968 0.00871080139372822
GO:BP GO:0019932 second-messenger-mediated signaling 0.00768491416889825 327 79 7 0.0886075949367089 0.0214067278287462
GO:BP GO:0032370 positive regulation of lipid transport 0.00779651235563597 87 34 3 0.0882352941176471 0.0344827586206897
GO:BP GO:0010033 response to organic substance 0.00779651235563597 3412 81 28 0.345679012345679 0.0082063305978898
GO:BP GO:0050994 regulation of lipid catabolic process 0.00779651235563597 60 49 3 0.0612244897959184 0.05
GO:BP GO:0022604 regulation of cell morphogenesis 0.0079857723921691 309 61 6 0.0983606557377049 0.0194174757281553
GO:BP GO:0000902 cell morphogenesis 0.00817107511740447 1037 61 11 0.180327868852459 0.0106075216972035
GO:BP GO:0071495 cellular response to endogenous stimulus 0.00833809869308984 1422 75 15 0.2 0.0105485232067511
GO:BP GO:0044283 small molecule biosynthetic process 0.00859443063787379 704 39 7 0.179487179487179 0.00994318181818182
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.00893978541778233 306 11 3 0.272727272727273 0.00980392156862745
GO:BP GO:0015914 phospholipid transport 0.00895690259313727 94 34 3 0.0882352941176471 0.0319148936170213
GO:BP GO:0046661 male sex differentiation 0.00901229220843307 163 20 3 0.15 0.0184049079754601
GO:BP GO:0001568 blood vessel development 0.00918873474286884 792 81 11 0.135802469135802 0.0138888888888889
GO:BP GO:0048729 tissue morphogenesis 0.00918873474286884 667 81 10 0.123456790123457 0.0149925037481259
GO:BP GO:0042221 response to chemical 0.00918873474286884 4781 81 35 0.432098765432099 0.00732064421669107
GO:BP GO:0009991 response to extracellular stimulus 0.00918873474286884 512 54 7 0.12962962962963 0.013671875
GO:BP GO:0007417 central nervous system development 0.00943226757187535 1032 73 12 0.164383561643836 0.0116279069767442
GO:BP GO:0009966 regulation of signal transduction 0.00955518955546177 3165 6 5 0.833333333333333 0.00157977883096367
GO:BP GO:1901564 organonitrogen compound metabolic process 0.00957215158848166 6792 75 42 0.56 0.00618374558303887
GO:BP GO:0007399 nervous system development 0.00967828054464112 2449 81 22 0.271604938271605 0.00898325847284606
GO:BP GO:0019933 cAMP-mediated signaling 0.00973471433954571 69 49 3 0.0612244897959184 0.0434782608695652
GO:BP GO:0022008 neurogenesis 0.0097751497094899 1675 73 16 0.219178082191781 0.00955223880597015
GO:BP GO:0034612 response to tumor necrosis factor 0.00995426356555011 331 11 3 0.272727272727273 0.00906344410876133
GO:BP GO:0001944 vasculature development 0.00995426356555011 830 5 3 0.6 0.0036144578313253
GO:BP GO:1902903 regulation of supramolecular fiber organization 0.0101937017176514 387 21 4 0.19047619047619 0.0103359173126615
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0105940557198321 2255 11 6 0.545454545454545 0.00266075388026608
GO:BP GO:0045123 cellular extravasation 0.0106929807072283 70 51 3 0.0588235294117647 0.0428571428571429
GO:BP GO:0006959 humoral immune response 0.0106929807072283 384 10 3 0.3 0.0078125
GO:BP GO:0006956 complement activation 0.0106929807072283 180 77 5 0.0649350649350649 0.0277777777777778
GO:BP GO:0048583 regulation of response to stimulus 0.0107503938385677 4278 81 32 0.395061728395062 0.00748013090229079
GO:BP GO:0097006 regulation of plasma lipoprotein particle levels 0.0109592664477582 107 34 3 0.0882352941176471 0.0280373831775701
GO:BP GO:0030155 regulation of cell adhesion 0.0110570763487048 748 63 9 0.142857142857143 0.0120320855614973
GO:BP GO:0031641 regulation of myelination 0.0110570763487048 45 81 3 0.037037037037037 0.0666666666666667
GO:BP GO:0031345 negative regulation of cell projection organization 0.0114237044974738 189 75 5 0.0666666666666667 0.0264550264550265
GO:BP GO:0050878 regulation of body fluid levels 0.0115792849432196 514 8 3 0.375 0.00583657587548638
GO:BP GO:0001822 kidney development 0.0116223715310578 293 73 6 0.0821917808219178 0.0204778156996587
GO:BP GO:1905954 positive regulation of lipid localization 0.0119475631988426 113 34 3 0.0882352941176471 0.0265486725663717
GO:BP GO:0032502 developmental process 0.0119506735408093 6628 21 15 0.714285714285714 0.00226312613156307
GO:BP GO:0065009 regulation of molecular function 0.0121506821829278 3221 81 26 0.320987654320988 0.00807202732070786
GO:BP GO:0021879 forebrain neuron differentiation 0.0121506821829278 53 73 3 0.0410958904109589 0.0566037735849057
GO:BP GO:0008543 fibroblast growth factor receptor signaling pathway 0.0125014349480634 116 75 4 0.0533333333333333 0.0344827586206897
GO:BP GO:0072001 renal system development 0.0125014349480634 302 73 6 0.0821917808219178 0.0198675496688742
GO:BP GO:0019538 protein metabolic process 0.0125014349480634 5808 75 37 0.493333333333333 0.00637052341597796
GO:BP GO:0030449 regulation of complement activation 0.0125014349480634 110 36 3 0.0833333333333333 0.0272727272727273
GO:BP GO:0043086 negative regulation of catalytic activity 0.0125014349480634 851 81 11 0.135802469135802 0.0129259694477086
GO:BP GO:0042060 wound healing 0.0125014349480634 549 8 3 0.375 0.00546448087431694
GO:BP GO:0048565 digestive tract development 0.0125656186727571 129 68 4 0.0588235294117647 0.0310077519379845
GO:BP GO:0048589 developmental growth 0.0125656186727571 649 75 9 0.12 0.0138674884437596
GO:BP GO:0043085 positive regulation of catalytic activity 0.0125656186727571 1418 81 15 0.185185185185185 0.0105782792665726
GO:BP GO:0050790 regulation of catalytic activity 0.0126732670055492 2545 81 22 0.271604938271605 0.00864440078585462
GO:BP GO:0010646 regulation of cell communication 0.0126975680686342 3543 6 5 0.833333333333333 0.00141123341800734
GO:BP GO:0060688 regulation of morphogenesis of a branching structure 0.0127053438643722 50 81 3 0.037037037037037 0.06
GO:BP GO:0023051 regulation of signaling 0.0128621819349748 3578 6 5 0.833333333333333 0.00139742873113471
GO:BP GO:0033674 positive regulation of kinase activity 0.0128621819349748 608 81 9 0.111111111111111 0.0148026315789474
GO:BP GO:0030334 regulation of cell migration 0.0128621819349748 999 81 12 0.148148148148148 0.012012012012012
GO:BP GO:0032501 multicellular organismal process 0.0128621819349748 7946 54 35 0.648148148148148 0.00440473194059904
GO:BP GO:0007186 G protein-coupled receptor signaling pathway 0.0130053461484326 1355 4 3 0.75 0.0022140221402214
GO:BP GO:0022617 extracellular matrix disassembly 0.0130852632056275 82 51 3 0.0588235294117647 0.0365853658536585
GO:BP GO:0048666 neuron development 0.0134329097181352 1149 81 13 0.160493827160494 0.0113141862489121
GO:BP GO:0043547 positive regulation of GTPase activity 0.0135304838500978 413 11 3 0.272727272727273 0.00726392251815981
GO:BP GO:0015850 organic hydroxy compound transport 0.0135858551440216 276 34 4 0.117647058823529 0.0144927536231884
GO:BP GO:2000026 regulation of multicellular organismal development 0.0135928241232337 1447 81 15 0.185185185185185 0.0103662750518314
GO:BP GO:0008406 gonad development 0.013720813182479 221 20 3 0.15 0.0135746606334842
GO:BP GO:0006629 lipid metabolic process 0.013720813182479 1457 50 11 0.22 0.00754975978037062
GO:BP GO:0043254 regulation of protein-containing complex assembly 0.013720813182479 460 21 4 0.19047619047619 0.00869565217391304
GO:BP GO:0055123 digestive system development 0.0139437330554945 138 68 4 0.0588235294117647 0.0289855072463768
GO:BP GO:0007010 cytoskeleton organization 0.0140216144131386 1423 4 3 0.75 0.00210822206605762
GO:BP GO:0044093 positive regulation of molecular function 0.0141949075159183 1771 81 17 0.209876543209877 0.00959909655561829
GO:BP GO:0006869 lipid transport 0.0142146325473127 480 34 5 0.147058823529412 0.0104166666666667
GO:BP GO:0045137 development of primary sexual characteristics 0.0142146325473127 227 20 3 0.15 0.013215859030837
GO:BP GO:0010647 positive regulation of cell communication 0.0145204192516054 1777 81 17 0.209876543209877 0.00956668542487338
GO:BP GO:0023056 positive regulation of signaling 0.0148338984132044 1782 81 17 0.209876543209877 0.00953984287317621
GO:BP GO:0021872 forebrain generation of neurons 0.0148338984132044 62 73 3 0.0410958904109589 0.0483870967741935
GO:BP GO:0015748 organophosphate ester transport 0.0151888356992713 136 34 3 0.0882352941176471 0.0220588235294118
GO:BP GO:0032940 secretion by cell 0.0151888356992713 1364 19 6 0.315789473684211 0.00439882697947214
GO:BP GO:0022612 gland morphogenesis 0.0151888356992713 120 81 4 0.0493827160493827 0.0333333333333333
GO:BP GO:0009653 anatomical structure morphogenesis 0.015211376788881 2797 81 23 0.283950617283951 0.00822309617447265
GO:BP GO:0051239 regulation of multicellular organismal process 0.0155888962447735 2861 75 22 0.293333333333333 0.00768961901433065
GO:BP GO:0009611 response to wounding 0.0156913641935514 674 63 8 0.126984126984127 0.0118694362017804
GO:BP GO:0032102 negative regulation of response to external stimulus 0.0157555854357978 406 81 7 0.0864197530864197 0.0172413793103448
GO:BP GO:0002920 regulation of humoral immune response 0.0159279150927777 133 36 3 0.0833333333333333 0.0225563909774436
GO:BP GO:0072359 circulatory system development 0.0160797264699943 1194 81 13 0.160493827160494 0.0108877721943049
GO:BP GO:0001655 urogenital system development 0.01614298983444 337 73 6 0.0821917808219178 0.0178041543026706
GO:BP GO:0016042 lipid catabolic process 0.0165882281461981 349 49 5 0.102040816326531 0.0143266475644699
GO:BP GO:0010977 negative regulation of neuron projection development 0.0166336084303051 140 35 3 0.0857142857142857 0.0214285714285714
GO:BP GO:0016192 vesicle-mediated transport 0.0167236248906942 2180 31 10 0.32258064516129 0.00458715596330275
GO:BP GO:0140352 export from cell 0.0167236248906942 1418 19 6 0.315789473684211 0.00423131170662906
GO:BP GO:0009967 positive regulation of signal transduction 0.016783445290266 1598 4 3 0.75 0.00187734668335419
GO:BP GO:2000145 regulation of cell motility 0.016783445290266 1061 81 12 0.148148148148148 0.0113100848256362
GO:BP GO:0006468 protein phosphorylation 0.0169926880524017 1668 81 16 0.197530864197531 0.00959232613908873
GO:BP GO:0001503 ossification 0.0169926880524017 417 81 7 0.0864197530864197 0.0167865707434053
GO:BP GO:0071496 cellular response to external stimulus 0.0171626132174248 322 54 5 0.0925925925925926 0.015527950310559
GO:BP GO:0048523 negative regulation of cellular process 0.0173725618743402 5139 75 33 0.44 0.00642148277875073
GO:BP GO:0019218 regulation of steroid metabolic process 0.0174971023723803 130 39 3 0.0769230769230769 0.0230769230769231
GO:BP GO:0043087 regulation of GTPase activity 0.0177173475291232 493 11 3 0.272727272727273 0.00608519269776876
GO:BP GO:0009887 animal organ morphogenesis 0.0177173475291232 1073 81 12 0.148148148148148 0.0111835973904939
GO:BP GO:0010876 lipid localization 0.0180771681036246 530 34 5 0.147058823529412 0.00943396226415094
GO:BP GO:0051128 regulation of cellular component organization 0.0180771681036246 2412 63 17 0.26984126984127 0.00704809286898839
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.0181327338884367 544 81 8 0.0987654320987654 0.0147058823529412
GO:BP GO:0051493 regulation of cytoskeleton organization 0.0181327338884367 531 21 4 0.19047619047619 0.00753295668549906
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.0181327338884367 543 81 8 0.0987654320987654 0.0147329650092081
GO:BP GO:0045833 negative regulation of lipid metabolic process 0.0187410304171827 108 49 3 0.0612244897959184 0.0277777777777778
GO:BP GO:0007420 brain development 0.0192400792106403 754 73 9 0.123287671232877 0.0119363395225464
GO:BP GO:0007548 sex differentiation 0.0194435152468607 275 20 3 0.15 0.0109090909090909
GO:BP GO:2000573 positive regulation of DNA biosynthetic process 0.019733282499509 67 81 3 0.037037037037037 0.0447761194029851
GO:BP GO:0046903 secretion 0.0198164737512622 1501 19 6 0.315789473684211 0.00399733510992672
GO:BP GO:0040012 regulation of locomotion 0.0205158612996858 1104 81 12 0.148148148148148 0.0108695652173913
GO:BP GO:0032956 regulation of actin cytoskeleton organization 0.0205339172864663 366 73 6 0.0821917808219178 0.0163934426229508
GO:BP GO:0051347 positive regulation of transferase activity 0.0206214735398708 689 81 9 0.111111111111111 0.0130624092888244
GO:BP GO:0033993 response to lipid 0.0207791176379938 918 73 10 0.136986301369863 0.0108932461873638
GO:BP GO:0051960 regulation of nervous system development 0.0208446119756599 443 81 7 0.0864197530864197 0.0158013544018059
GO:BP GO:0097305 response to alcohol 0.0208446119756599 255 73 5 0.0684931506849315 0.0196078431372549
GO:BP GO:0048519 negative regulation of biological process 0.0220962768282674 5757 54 27 0.5 0.00468994267847837
GO:BP GO:0009314 response to radiation 0.022464703525892 461 60 6 0.1 0.0130151843817787
GO:BP GO:0000381 regulation of alternative mRNA splicing, via spliceosome 0.023015096935604 78 76 3 0.0394736842105263 0.0384615384615385
GO:BP GO:0007626 locomotory behavior 0.0234136953465877 189 32 3 0.09375 0.0158730158730159
GO:BP GO:0061564 axon development 0.0236036837909219 523 54 6 0.111111111111111 0.011472275334608
GO:BP GO:0030900 forebrain development 0.0237852803443102 385 73 6 0.0821917808219178 0.0155844155844156
GO:BP GO:0051270 regulation of cellular component movement 0.0239383674161699 1141 81 12 0.148148148148148 0.0105170902716915
GO:BP GO:0006950 response to stress 0.0239383674161699 4170 11 7 0.636363636363636 0.00167865707434053
GO:BP GO:0060322 head development 0.0239550754317097 798 73 9 0.123287671232877 0.0112781954887218
GO:BP GO:0021954 central nervous system neuron development 0.0242202003990697 84 73 3 0.0410958904109589 0.0357142857142857
GO:BP GO:0030030 cell projection organization 0.0242202003990697 1609 81 15 0.185185185185185 0.00932256059664388
GO:BP GO:0048522 positive regulation of cellular process 0.0247659639344392 5757 75 35 0.466666666666667 0.00607955532395345
GO:BP GO:0046777 protein autophosphorylation 0.0248962893192835 240 52 4 0.0769230769230769 0.0166666666666667
GO:BP GO:1902904 negative regulation of supramolecular fiber organization 0.0248962893192835 170 73 4 0.0547945205479452 0.0235294117647059
GO:BP GO:0022411 cellular component disassembly 0.0253552472361852 571 51 6 0.117647058823529 0.010507880910683
GO:BP GO:0002684 positive regulation of immune system process 0.0254199937827682 1065 77 11 0.142857142857143 0.0103286384976526
GO:BP GO:0070887 cellular response to chemical stimulus 0.0255044711340631 3393 5 4 0.8 0.00117889773062187
GO:BP GO:0045765 regulation of angiogenesis 0.0258913925298892 358 81 6 0.0740740740740741 0.0167597765363128
GO:BP GO:0019216 regulation of lipid metabolic process 0.0258913925298892 419 49 5 0.102040816326531 0.0119331742243437
GO:BP GO:0046394 carboxylic acid biosynthetic process 0.026024867236112 330 39 4 0.102564102564103 0.0121212121212121
GO:BP GO:0055088 lipid homeostasis 0.0263231417211782 167 39 3 0.0769230769230769 0.0179640718562874
GO:BP GO:0045834 positive regulation of lipid metabolic process 0.0263231417211782 155 42 3 0.0714285714285714 0.0193548387096774
GO:BP GO:0021761 limbic system development 0.0263231417211782 103 63 3 0.0476190476190476 0.029126213592233
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.0269895245747692 3087 75 22 0.293333333333333 0.00712666018788468
GO:BP GO:1901342 regulation of vasculature development 0.0270741606122552 364 81 6 0.0740740740740741 0.0164835164835165
GO:BP GO:0019220 regulation of phosphate metabolic process 0.0270741606122552 1645 81 15 0.185185185185185 0.00911854103343465
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.0270741606122552 1645 81 15 0.185185185185185 0.00911854103343465
GO:BP GO:0016053 organic acid biosynthetic process 0.0271702598901341 338 39 4 0.102564102564103 0.0118343195266272
GO:BP GO:0032970 regulation of actin filament-based process 0.0272272527691305 406 73 6 0.0821917808219178 0.0147783251231527
GO:BP GO:0000380 alternative mRNA splicing, via spliceosome 0.0283182364771398 89 76 3 0.0394736842105263 0.0337078651685393
GO:BP GO:0031668 cellular response to extracellular stimulus 0.0288099610077436 248 54 4 0.0740740740740741 0.0161290322580645
GO:BP GO:0040007 growth 0.0288099610077436 967 75 10 0.133333333333333 0.0103412616339193
GO:BP GO:0006793 phosphorus metabolic process 0.0288920706718122 3114 75 22 0.293333333333333 0.00706486833654464
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0295766849576972 2518 81 20 0.246913580246914 0.0079428117553614
GO:BP GO:0032496 response to lipopolysaccharide 0.0304975576694497 338 64 5 0.078125 0.014792899408284
GO:BP GO:0050789 regulation of biological process 0.0305331681744487 12091 23 21 0.91304347826087 0.00173682904639815
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0306015184594758 1202 81 12 0.148148148148148 0.00998336106489185
GO:BP GO:0021953 central nervous system neuron differentiation 0.0307819365246807 188 73 4 0.0547945205479452 0.0212765957446809
GO:BP GO:0120036 plasma membrane bounded cell projection organization 0.0310915299410491 1569 63 12 0.19047619047619 0.00764818355640535
GO:BP GO:0042063 gliogenesis 0.0310915299410491 308 71 5 0.0704225352112676 0.0162337662337662
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.031327721742771 2719 81 21 0.259259259259259 0.00772342773078338
GO:BP GO:0048863 stem cell differentiation 0.031327721742771 258 54 4 0.0740740740740741 0.0155038759689922
GO:BP GO:0050728 negative regulation of inflammatory response 0.031327721742771 171 81 4 0.0493827160493827 0.0233918128654971
GO:BP GO:0048856 anatomical structure development 0.0319796838692047 6106 21 13 0.619047619047619 0.00212905339010809
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0319796838692047 385 81 6 0.0740740740740741 0.0155844155844156
GO:BP GO:0048608 reproductive structure development 0.0320109574047082 429 73 6 0.0821917808219178 0.013986013986014
GO:BP GO:0044092 negative regulation of molecular function 0.03231714846441 1219 81 12 0.148148148148148 0.00984413453650533
GO:BP GO:0071310 cellular response to organic substance 0.0325421738181952 2776 75 20 0.266666666666667 0.00720461095100865
GO:BP GO:0018212 peptidyl-tyrosine modification 0.0325421738181952 388 81 6 0.0740740740740741 0.0154639175257732
GO:BP GO:0043549 regulation of kinase activity 0.0325421738181952 921 81 10 0.123456790123457 0.01085776330076
GO:BP GO:0061458 reproductive system development 0.0326963510248143 432 73 6 0.0821917808219178 0.0138888888888889
GO:BP GO:0031347 regulation of defense response 0.0329067107973065 704 21 4 0.19047619047619 0.00568181818181818
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0332372935091434 982 54 8 0.148148148148148 0.00814663951120163
GO:BP GO:0006887 exocytosis 0.0332372935091434 904 36 6 0.166666666666667 0.00663716814159292
GO:BP GO:0048839 inner ear development 0.0339305148853429 193 75 4 0.0533333333333333 0.0207253886010363
GO:BP GO:0008361 regulation of cell size 0.0342754645383526 182 42 3 0.0714285714285714 0.0164835164835165
GO:BP GO:0045862 positive regulation of proteolysis 0.0342995289478037 378 39 4 0.102564102564103 0.0105820105820106
GO:BP GO:0048667 cell morphogenesis involved in neuron differentiation 0.0348107528747146 602 54 6 0.111111111111111 0.00996677740863787
GO:BP GO:0050768 negative regulation of neurogenesis 0.0350713391429083 143 54 3 0.0555555555555556 0.020979020979021
GO:BP GO:0002237 response to molecule of bacterial origin 0.0350713391429083 361 64 5 0.078125 0.0138504155124654
GO:BP GO:0050804 modulation of chemical synaptic transmission 0.0351513330148053 430 54 5 0.0925925925925926 0.0116279069767442
GO:BP GO:0048568 embryonic organ development 0.0351513330148053 432 75 6 0.08 0.0138888888888889
GO:BP GO:0099177 regulation of trans-synaptic signaling 0.0353247087860505 431 54 5 0.0925925925925926 0.0116009280742459
GO:BP GO:0007015 actin filament organization 0.0353247087860505 445 73 6 0.0821917808219178 0.0134831460674157
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 0.0356163353902506 124 63 3 0.0476190476190476 0.0241935483870968
GO:BP GO:0030278 regulation of ossification 0.0356163353902506 115 68 3 0.0441176470588235 0.0260869565217391
GO:BP GO:0050727 regulation of inflammatory response 0.0356163353902506 381 21 3 0.142857142857143 0.0078740157480315
GO:BP GO:0016055 Wnt signaling pathway 0.0356910199614241 529 62 6 0.0967741935483871 0.0113421550094518
GO:BP GO:2000027 regulation of animal organ morphogenesis 0.0357174928417765 184 81 4 0.0493827160493827 0.0217391304347826
GO:BP GO:0051897 positive regulation of protein kinase B signaling 0.0357174928417765 184 81 4 0.0493827160493827 0.0217391304347826
GO:BP GO:0198738 cell-cell signaling by wnt 0.0358569480401633 531 62 6 0.0967741935483871 0.0112994350282486
GO:BP GO:0030282 bone mineralization 0.0358569480401633 116 68 3 0.0441176470588235 0.0258620689655172
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0358569480401633 1082 8 3 0.375 0.00277264325323475
GO:BP GO:0009892 negative regulation of metabolic process 0.0364752626445675 3479 54 18 0.333333333333333 0.00517390054613395
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0364752626445675 1103 81 11 0.135802469135802 0.0099728014505893
GO:BP GO:0051961 negative regulation of nervous system development 0.0364752626445675 148 54 3 0.0555555555555556 0.0202702702702703
GO:BP GO:0050896 response to stimulus 0.0366114169792115 9407 54 37 0.685185185185185 0.0039332412033592
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0375277414245178 783 11 3 0.272727272727273 0.00383141762452107
GO:BP GO:0050806 positive regulation of synaptic transmission 0.0380439310249906 152 54 3 0.0555555555555556 0.0197368421052632
GO:BP GO:0002687 positive regulation of leukocyte migration 0.0381795498972262 137 60 3 0.05 0.0218978102189781
GO:BP GO:0065007 biological regulation 0.0382763338547057 12809 54 46 0.851851851851852 0.00359122491997814
GO:BP GO:0052548 regulation of endopeptidase activity 0.0382763338547057 437 36 4 0.111111111111111 0.0091533180778032
GO:BP GO:0046890 regulation of lipid biosynthetic process 0.0389215381984664 215 39 3 0.0769230769230769 0.013953488372093
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0393365809763332 1151 8 3 0.375 0.00260642919200695
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0393365809763332 810 11 3 0.272727272727273 0.0037037037037037
GO:BP GO:0060070 canonical Wnt signaling pathway 0.0393365809763332 345 46 4 0.0869565217391304 0.0115942028985507
GO:BP GO:0006665 sphingolipid metabolic process 0.0395413553976663 169 50 3 0.06 0.0177514792899408
GO:BP GO:0007275 multicellular organism development 0.0398703714387853 5613 21 12 0.571428571428571 0.00213789417423838
GO:BP GO:0045471 response to ethanol 0.0401344471753841 142 60 3 0.05 0.0211267605633803
GO:BP GO:0010001 glial cell differentiation 0.0403719939131868 225 71 4 0.0563380281690141 0.0177777777777778
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0409054183941734 1455 81 13 0.160493827160494 0.00893470790378007
GO:BP GO:0050794 regulation of cellular process 0.0409054183941734 11473 23 20 0.869565217391304 0.00174322321973329
GO:BP GO:0007409 axonogenesis 0.0416556780816576 478 73 6 0.0821917808219178 0.0125523012552301
GO:BP GO:0016043 cellular component organization 0.0416556780816576 6566 63 32 0.507936507936508 0.00487359122753579
GO:BP GO:0002688 regulation of leukocyte chemotaxis 0.0416556780816576 120 73 3 0.0410958904109589 0.025
GO:BP GO:0072330 monocarboxylic acid biosynthetic process 0.0416556780816576 226 39 3 0.0769230769230769 0.0132743362831858
GO:BP GO:0043583 ear development 0.0419200059790072 218 75 4 0.0533333333333333 0.018348623853211
GO:BP GO:0002697 regulation of immune effector process 0.0420184534180799 461 36 4 0.111111111111111 0.00867678958785249
GO:BP GO:0050920 regulation of chemotaxis 0.0428182125317146 226 73 4 0.0547945205479452 0.0176991150442478
GO:BP GO:0043687 post-translational protein modification 0.0428182125317146 362 25 3 0.12 0.00828729281767956
GO:BP GO:0048675 axon extension 0.0428438433668733 122 73 3 0.0410958904109589 0.0245901639344262
GO:BP GO:0002252 immune effector process 0.0429694597708415 1309 36 7 0.194444444444444 0.0053475935828877
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 0.0429694597708415 119 75 3 0.04 0.0252100840336134
GO:BP GO:0052547 regulation of peptidase activity 0.0431878932529487 467 36 4 0.111111111111111 0.00856531049250535
GO:BP GO:0043405 regulation of MAP kinase activity 0.0437065386319783 316 81 5 0.0617283950617284 0.0158227848101266
GO:BP GO:0048024 regulation of mRNA splicing, via spliceosome 0.0439326246099226 119 76 3 0.0394736842105263 0.0252100840336134
GO:BP GO:0048812 neuron projection morphogenesis 0.0439346088589114 664 54 6 0.111111111111111 0.00903614457831325
GO:BP GO:2000278 regulation of DNA biosynthetic process 0.0439346088589114 112 81 3 0.037037037037037 0.0267857142857143
GO:BP GO:0099173 postsynapse organization 0.0441441975082931 169 54 3 0.0555555555555556 0.0177514792899408
GO:BP GO:0048585 negative regulation of response to stimulus 0.0441441975082931 1733 6 3 0.5 0.00173110213502597
GO:BP GO:1903034 regulation of response to wounding 0.0441441975082931 169 54 3 0.0555555555555556 0.0177514792899408
GO:BP GO:0042127 regulation of cell population proliferation 0.0446237113474333 1774 54 11 0.203703703703704 0.00620067643742954
GO:BP GO:0060429 epithelium development 0.0449171725755628 1325 81 12 0.148148148148148 0.00905660377358491
GO:BP GO:0031400 negative regulation of protein modification process 0.0457683516984942 578 81 7 0.0864197530864197 0.0121107266435986
GO:BP GO:0048588 developmental cell growth 0.0457705631110632 235 73 4 0.0547945205479452 0.0170212765957447
GO:BP GO:0050776 regulation of immune response 0.0457705631110632 996 10 3 0.3 0.00301204819277108
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 0.0459692323486662 678 54 6 0.111111111111111 0.00884955752212389
GO:BP GO:1903510 mucopolysaccharide metabolic process 0.0460625193861227 116 81 3 0.037037037037037 0.0258620689655172
GO:BP GO:0048858 cell projection morphogenesis 0.0466896028717717 682 54 6 0.111111111111111 0.00879765395894428
GO:BP GO:0003206 cardiac chamber morphogenesis 0.0467658191130006 120 79 3 0.0379746835443038 0.025
GO:BP GO:0008610 lipid biosynthetic process 0.0469218529507015 740 50 6 0.12 0.00810810810810811
GO:BP GO:0050680 negative regulation of epithelial cell proliferation 0.0474406493682746 178 54 3 0.0555555555555556 0.0168539325842697
GO:BP GO:0050767 regulation of neurogenesis 0.0474406493682746 366 73 5 0.0684931506849315 0.0136612021857923
GO:BP GO:0008283 cell population proliferation 0.0474970836261267 2054 54 12 0.222222222222222 0.00584225900681597
GO:BP GO:0051338 regulation of transferase activity 0.0489379420241856 1035 81 10 0.123456790123457 0.00966183574879227
GO:BP GO:0016032 viral process 0.0491456516672181 942 11 3 0.272727272727273 0.00318471337579618
GO:BP GO:0010594 regulation of endothelial cell migration 0.0491601275324204 244 73 4 0.0547945205479452 0.0163934426229508
GO:BP GO:0007584 response to nutrient 0.0492511971789179 182 54 3 0.0555555555555556 0.0164835164835165
GO:BP GO:1901617 organic hydroxy compound biosynthetic process 0.0495547902183984 254 39 3 0.0769230769230769 0.0118110236220472
GO:BP GO:0010721 negative regulation of cell development 0.0497040909956338 183 54 3 0.0555555555555556 0.0163934426229508
GO:BP GO:0032990 cell part morphogenesis 0.0498180095952231 699 54 6 0.111111111111111 0.00858369098712446
GO:CC GO:0030312 external encapsulating structure 1.38106690180536e-11 563 70 19 0.271428571428571 0.0337477797513321
GO:CC GO:0031012 extracellular matrix 1.38106690180536e-11 562 70 19 0.271428571428571 0.0338078291814947
GO:CC GO:0005576 extracellular region 7.43920061036548e-10 4567 57 38 0.666666666666667 0.00832056054302606
GO:CC GO:0062023 collagen-containing extracellular matrix 7.43920061036548e-10 421 55 14 0.254545454545455 0.0332541567695962
GO:CC GO:0005615 extracellular space 1.47326591496041e-06 3594 47 26 0.553191489361702 0.00723427935447969
GO:CC GO:0071944 cell periphery 8.74161571716241e-05 6169 70 42 0.6 0.00680823472199708
GO:CC GO:0072562 blood microparticle 0.000229740443805341 140 36 5 0.138888888888889 0.0357142857142857
GO:CC GO:0034364 high-density lipoprotein particle 0.000585057428709344 29 34 3 0.0882352941176471 0.103448275862069
GO:CC GO:0031091 platelet alpha granule 0.000694313900491894 90 36 4 0.111111111111111 0.0444444444444444
GO:CC GO:0005788 endoplasmic reticulum lumen 0.000917559763009084 307 25 5 0.2 0.0162866449511401
GO:CC GO:0034358 plasma lipoprotein particle 0.000917559763009084 38 34 3 0.0882352941176471 0.0789473684210526
GO:CC GO:1990777 lipoprotein particle 0.000917559763009084 38 34 3 0.0882352941176471 0.0789473684210526
GO:CC GO:0032994 protein-lipid complex 0.00103501405024854 41 34 3 0.0882352941176471 0.0731707317073171
GO:CC GO:0031093 platelet alpha granule lumen 0.00304817323300932 66 81 4 0.0493827160493827 0.0606060606060606
GO:CC GO:0044297 cell body 0.00833256177498207 592 48 7 0.145833333333333 0.0118243243243243
GO:CC GO:0005794 Golgi apparatus 0.00833256177498207 1623 77 16 0.207792207792208 0.00985828712261245
GO:CC GO:0070062 extracellular exosome 0.012767245284921 2176 45 13 0.288888888888889 0.00597426470588235
GO:CC GO:0031594 neuromuscular junction 0.012767245284921 73 54 3 0.0555555555555556 0.0410958904109589
GO:CC GO:0005783 endoplasmic reticulum 0.0145034878247364 1982 39 11 0.282051282051282 0.00554994954591322
GO:CC GO:0031983 vesicle lumen 0.0145034878247364 326 51 5 0.0980392156862745 0.0153374233128834
GO:CC GO:0034774 secretory granule lumen 0.0145034878247364 320 51 5 0.0980392156862745 0.015625
GO:CC GO:1903561 extracellular vesicle 0.0145034878247364 2261 45 13 0.288888888888889 0.00574966828836798
GO:CC GO:0043230 extracellular organelle 0.0145034878247364 2263 45 13 0.288888888888889 0.00574458683163942
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0145034878247364 324 51 5 0.0980392156862745 0.0154320987654321
GO:CC GO:0043025 neuronal cell body 0.0146906881236207 518 48 6 0.125 0.0115830115830116
GO:CC GO:0005938 cell cortex 0.0238446337202479 311 61 5 0.0819672131147541 0.0160771704180064
GO:MF GO:0005539 glycosaminoglycan binding 4.9798456307816e-08 238 73 12 0.164383561643836 0.0504201680672269
GO:MF GO:0008201 heparin binding 1.95646726947488e-07 168 73 10 0.136986301369863 0.0595238095238095
GO:MF GO:1901681 sulfur compound binding 9.84647930641614e-06 264 73 10 0.136986301369863 0.0378787878787879
GO:MF GO:0005201 extracellular matrix structural constituent 6.46974168779811e-05 171 55 7 0.127272727272727 0.0409356725146199
GO:MF GO:0008009 chemokine activity 0.000177981026643577 49 11 3 0.272727272727273 0.0612244897959184
GO:MF GO:0048020 CCR chemokine receptor binding 0.000177981026643577 48 11 3 0.272727272727273 0.0625
GO:MF GO:0097367 carbohydrate derivative binding 0.000178986191798442 2285 73 24 0.328767123287671 0.0105032822757112
GO:MF GO:0005102 signaling receptor binding 0.000218766993579263 1672 17 9 0.529411764705882 0.00538277511961723
GO:MF GO:0019199 transmembrane receptor protein kinase activity 0.000329816328128816 82 62 5 0.0806451612903226 0.0609756097560976
GO:MF GO:0042379 chemokine receptor binding 0.000343134714605546 72 11 3 0.272727272727273 0.0416666666666667
GO:MF GO:0043394 proteoglycan binding 0.000404940823874976 36 73 4 0.0547945205479452 0.111111111111111
GO:MF GO:0004857 enzyme inhibitor activity 0.000746831388362142 385 75 9 0.12 0.0233766233766234
GO:MF GO:0001664 G protein-coupled receptor binding 0.00104244462044035 292 60 7 0.116666666666667 0.023972602739726
GO:MF GO:0004714 transmembrane receptor protein tyrosine kinase activity 0.00110885123535623 63 62 4 0.0645161290322581 0.0634920634920635
GO:MF GO:0005125 cytokine activity 0.00110885123535623 235 17 4 0.235294117647059 0.0170212765957447
GO:MF GO:0019838 growth factor binding 0.00110885123535623 138 54 5 0.0925925925925926 0.036231884057971
GO:MF GO:0048018 receptor ligand activity 0.00110885123535623 494 81 10 0.123456790123457 0.0202429149797571
GO:MF GO:0030546 signaling receptor activator activity 0.00110885123535623 501 81 10 0.123456790123457 0.0199600798403194
GO:MF GO:0030545 receptor regulator activity 0.00196720019090695 545 81 10 0.123456790123457 0.018348623853211
GO:MF GO:0098772 molecular function regulator 0.00196720019090695 2363 81 23 0.283950617283951 0.00973338975878121
GO:MF GO:0005198 structural molecule activity 0.00241656296731804 698 23 6 0.260869565217391 0.00859598853868195
GO:MF GO:0004713 protein tyrosine kinase activity 0.0026692149914957 144 68 5 0.0735294117647059 0.0347222222222222
GO:MF GO:0005319 lipid transporter activity 0.00332525085696713 167 34 4 0.117647058823529 0.0239520958083832
GO:MF GO:0004672 protein kinase activity 0.00367273564613346 587 68 9 0.132352941176471 0.0153321976149915
GO:MF GO:0004222 metalloendopeptidase activity 0.00440377676423652 108 57 4 0.0701754385964912 0.037037037037037
GO:MF GO:0005126 cytokine receptor binding 0.00595971177622821 275 11 3 0.272727272727273 0.0109090909090909
GO:MF GO:0016301 kinase activity 0.00678284364865851 796 68 10 0.147058823529412 0.0125628140703518
GO:MF GO:0061134 peptidase regulator activity 0.00678284364865851 224 14 3 0.214285714285714 0.0133928571428571
GO:MF GO:0004175 endopeptidase activity 0.00803679119893578 450 81 8 0.0987654320987654 0.0177777777777778
GO:MF GO:0016773 phosphotransferase activity, alcohol group as acceptor 0.0084395748777093 692 68 9 0.132352941176471 0.0130057803468208
GO:MF GO:0005178 integrin binding 0.0084395748777093 147 54 4 0.0740740740740741 0.0272108843537415
GO:MF GO:0140096 catalytic activity, acting on a protein 0.0122895189531648 2332 74 19 0.256756756756757 0.008147512864494
GO:MF GO:0030234 enzyme regulator activity 0.0126800132704263 1248 14 5 0.357142857142857 0.00400641025641026
GO:MF GO:0008233 peptidase activity 0.013081666475094 646 81 9 0.111111111111111 0.0139318885448916
GO:MF GO:0046983 protein dimerization activity 0.013081666475094 1069 5 3 0.6 0.00280636108512629
GO:MF GO:0016772 transferase activity, transferring phosphorus-containing groups 0.0140373361706242 952 68 10 0.147058823529412 0.0105042016806723
GO:MF GO:0043167 ion binding 0.0186719273483509 6057 36 20 0.555555555555556 0.00330196466897804
GO:MF GO:0004252 serine-type endopeptidase activity 0.028727149742582 171 81 4 0.0493827160493827 0.0233918128654971
GO:MF GO:0008047 enzyme activator activity 0.0296585692944082 540 14 3 0.214285714285714 0.00555555555555556
GO:MF GO:0043168 anion binding 0.0320791725179418 2418 71 17 0.23943661971831 0.00703060380479735
GO:MF GO:0008236 serine-type peptidase activity 0.0342598860392773 189 81 4 0.0493827160493827 0.0211640211640212
GO:MF GO:0017171 serine hydrolase activity 0.0361817370639642 193 81 4 0.0493827160493827 0.0207253886010363
GO:MF GO:0008289 lipid binding 0.0393958288532029 776 34 5 0.147058823529412 0.00644329896907216
GO:MF GO:0019901 protein kinase binding 0.0491592014585214 673 75 7 0.0933333333333333 0.0104011887072808
KEGG KEGG:04061 Viral protein interaction with cytokine and cytokine receptor 0.039702334605562 98 11 3 0.272727272727273 0.0306122448979592
REAC REAC:R-HSA-8963898 Plasma lipoprotein assembly 0.00387212983785092 18 27 3 0.111111111111111 0.166666666666667
REAC REAC:R-HSA-114608 Platelet degranulation 0.0444638255058891 125 36 4 0.111111111111111 0.032
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.0444638255058891 130 36 4 0.111111111111111 0.0307692307692308
REAC REAC:R-HSA-1474244 Extracellular matrix organization 0.0444638255058891 298 55 7 0.127272727272727 0.023489932885906
TF TF:M00947_1 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG; match class: 1 0.0290981512115191 2651 73 25 0.342465753424658 0.00943040362127499

pS11 transcription factor target enrichment of top program genes

TF enrichment of pS11
TFs corrosponding to activation of pS11. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.