pEpiTp19 program activity among Epithelial cells

Activation of pEpiTp19
pEpiTp19 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp19 by different cell subtypes
pEpiTp19 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp19 top program genes

Top genes of pEpiTp19 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp19 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp19
pEpiTp19 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:6859 HRD1 complex 0.00717405244040537 13 39 3 0.0769230769230769 0.230769230769231
GO:BP GO:0035966 response to topologically incorrect protein 4.56959003331308e-11 205 99 16 0.161616161616162 0.0780487804878049
GO:BP GO:0006986 response to unfolded protein 4.56959003331308e-11 184 76 14 0.184210526315789 0.0760869565217391
GO:BP GO:0006457 protein folding 9.67241955537379e-11 225 137 18 0.131386861313869 0.08
GO:BP GO:0035967 cellular response to topologically incorrect protein 2.94782344823912e-10 168 99 14 0.141414141414141 0.0833333333333333
GO:BP GO:0034620 cellular response to unfolded protein 7.37584524485352e-10 149 76 12 0.157894736842105 0.0805369127516778
GO:BP GO:0034976 response to endoplasmic reticulum stress 3.89195057909949e-08 298 99 15 0.151515151515152 0.0503355704697987
GO:BP GO:0034975 protein folding in endoplasmic reticulum 3.50115380723816e-07 11 85 5 0.0588235294117647 0.454545454545455
GO:BP GO:0051641 cellular localization 3.50115380723816e-07 3541 83 41 0.493975903614458 0.0115786500988421
GO:BP GO:0070972 protein localization to endoplasmic reticulum 4.22902875297653e-07 146 83 10 0.120481927710843 0.0684931506849315
GO:BP GO:0030968 endoplasmic reticulum unfolded protein response 6.07182053698375e-07 128 99 10 0.101010101010101 0.078125
GO:BP GO:0036498 IRE1-mediated unfolded protein response 8.28058038763556e-07 67 99 8 0.0808080808080808 0.119402985074627
GO:BP GO:0051234 establishment of localization 1.2352602857158e-05 5372 31 24 0.774193548387097 0.00446760982874162
GO:BP GO:0030003 cellular cation homeostasis 1.2352602857158e-05 673 29 10 0.344827586206897 0.0148588410104012
GO:BP GO:0006873 cellular ion homeostasis 1.30855851236596e-05 687 29 10 0.344827586206897 0.0145560407569141
GO:BP GO:0055080 cation homeostasis 2.58317149500632e-05 750 29 10 0.344827586206897 0.0133333333333333
GO:BP GO:0019725 cellular homeostasis 2.58317149500632e-05 981 35 12 0.342857142857143 0.0122324159021407
GO:BP GO:0010248 establishment or maintenance of transmembrane electrochemical gradient 2.58317149500632e-05 13 16 3 0.1875 0.230769230769231
GO:BP GO:0098771 inorganic ion homeostasis 2.58317149500632e-05 761 29 10 0.344827586206897 0.0131406044678055
GO:BP GO:0140352 export from cell 2.58317149500632e-05 1418 40 15 0.375 0.0105782792665726
GO:BP GO:0036500 ATF6-mediated unfolded protein response 2.62220183180233e-05 10 99 4 0.0404040404040404 0.4
GO:BP GO:0030004 cellular monovalent inorganic cation homeostasis 2.7626175189317e-05 118 21 5 0.238095238095238 0.0423728813559322
GO:BP GO:0006875 cellular metal ion homeostasis 2.7626175189317e-05 593 29 9 0.310344827586207 0.015177065767285
GO:BP GO:0006810 transport 2.7626175189317e-05 5224 31 23 0.741935483870968 0.00440275650842266
GO:BP GO:0030007 cellular potassium ion homeostasis 2.7626175189317e-05 14 16 3 0.1875 0.214285714285714
GO:BP GO:0051085 chaperone cofactor-dependent protein refolding 2.7626175189317e-05 31 31 4 0.129032258064516 0.129032258064516
GO:BP GO:0036376 sodium ion export across plasma membrane 2.99993030507542e-05 15 16 3 0.1875 0.2
GO:BP GO:0050801 ion homeostasis 3.0806812083934e-05 808 29 10 0.344827586206897 0.0123762376237624
GO:BP GO:0051649 establishment of localization in cell 3.23208422571958e-05 2813 83 32 0.385542168674699 0.0113757554212584
GO:BP GO:0051084 'de novo' posttranslational protein folding 4.04588607310502e-05 36 31 4 0.129032258064516 0.111111111111111
GO:BP GO:0055082 cellular chemical homeostasis 4.04588607310502e-05 841 29 10 0.344827586206897 0.0118906064209275
GO:BP GO:0006458 'de novo' protein folding 5.85677960825904e-05 40 31 4 0.129032258064516 0.1
GO:BP GO:0055065 metal ion homeostasis 5.85677960825904e-05 667 29 9 0.310344827586207 0.0134932533733133
GO:BP GO:1902307 positive regulation of sodium ion transmembrane transport 6.68409666342113e-05 21 16 3 0.1875 0.142857142857143
GO:BP GO:0006883 cellular sodium ion homeostasis 6.68409666342113e-05 21 16 3 0.1875 0.142857142857143
GO:BP GO:0045047 protein targeting to ER 7.12824343655005e-05 113 83 7 0.0843373493975904 0.0619469026548673
GO:BP GO:0002028 regulation of sodium ion transport 7.12824343655005e-05 87 16 4 0.25 0.0459770114942529
GO:BP GO:1902600 proton transmembrane transport 7.12824343655005e-05 157 21 5 0.238095238095238 0.0318471337579618
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 8.47306736563441e-05 117 83 7 0.0843373493975904 0.0598290598290598
GO:BP GO:0055067 monovalent inorganic cation homeostasis 8.47306736563441e-05 165 21 5 0.238095238095238 0.0303030303030303
GO:BP GO:0006984 ER-nucleus signaling pathway 0.00011206154488163 53 29 4 0.137931034482759 0.0754716981132075
GO:BP GO:0050821 protein stabilization 0.000132065540882689 193 20 5 0.25 0.0259067357512953
GO:BP GO:0055075 potassium ion homeostasis 0.000164377335081827 30 16 3 0.1875 0.1
GO:BP GO:0006887 exocytosis 0.000194416565851582 904 40 11 0.275 0.0121681415929204
GO:BP GO:0061077 chaperone-mediated protein folding 0.000231935483197221 61 31 4 0.129032258064516 0.0655737704918033
GO:BP GO:0051604 protein maturation 0.000231935483197221 306 113 11 0.0973451327433628 0.0359477124183007
GO:BP GO:0010765 positive regulation of sodium ion transport 0.000236160675596991 35 16 3 0.1875 0.0857142857142857
GO:BP GO:0098662 inorganic cation transmembrane transport 0.000236160675596991 794 23 8 0.347826086956522 0.0100755667506297
GO:BP GO:1903573 negative regulation of response to endoplasmic reticulum stress 0.000308387522803662 46 99 5 0.0505050505050505 0.108695652173913
GO:BP GO:0006605 protein targeting 0.000313577733573537 441 83 11 0.132530120481928 0.0249433106575964
GO:BP GO:0045055 regulated exocytosis 0.000335833095758756 785 40 10 0.25 0.0127388535031847
GO:BP GO:0051179 localization 0.000356618674853818 6901 43 31 0.720930232558139 0.00449210259382698
GO:BP GO:1905897 regulation of response to endoplasmic reticulum stress 0.000372223325531558 84 99 6 0.0606060606060606 0.0714285714285714
GO:BP GO:0032940 secretion by cell 0.000372223325531558 1364 81 19 0.234567901234568 0.0139296187683284
GO:BP GO:0042026 protein refolding 0.000421005028924206 23 31 3 0.0967741935483871 0.130434782608696
GO:BP GO:0098660 inorganic ion transmembrane transport 0.000421005028924206 883 23 8 0.347826086956522 0.00906002265005663
GO:BP GO:0043312 neutrophil degranulation 0.000453335726495558 482 40 8 0.2 0.016597510373444
GO:BP GO:1990573 potassium ion import across plasma membrane 0.000458496518310092 47 16 3 0.1875 0.0638297872340425
GO:BP GO:0002283 neutrophil activation involved in immune response 0.000458496518310092 485 40 8 0.2 0.0164948453608247
GO:BP GO:0086009 membrane repolarization 0.000477497350658109 48 16 3 0.1875 0.0625
GO:BP GO:0098655 cation transmembrane transport 0.000498707147129759 914 23 8 0.347826086956522 0.0087527352297593
GO:BP GO:0042119 neutrophil activation 0.00052104082730268 498 40 8 0.2 0.0160642570281124
GO:BP GO:0002446 neutrophil mediated immunity 0.00052104082730268 497 40 8 0.2 0.0160965794768612
GO:BP GO:0070839 metal ion export 0.000538672793960536 51 16 3 0.1875 0.0588235294117647
GO:BP GO:0036230 granulocyte activation 0.000551133950794646 504 40 8 0.2 0.0158730158730159
GO:BP GO:0048878 chemical homeostasis 0.00055147707404812 1229 29 10 0.344827586206897 0.0081366965012205
GO:BP GO:0035725 sodium ion transmembrane transport 0.000573064163784258 171 16 4 0.25 0.0233918128654971
GO:BP GO:0016192 vesicle-mediated transport 0.000619614198642898 2180 42 16 0.380952380952381 0.0073394495412844
GO:BP GO:0006465 signal peptide processing 0.000649467181605411 11 83 3 0.036144578313253 0.272727272727273
GO:BP GO:0031647 regulation of protein stability 0.000649467181605411 300 20 5 0.25 0.0166666666666667
GO:BP GO:0055078 sodium ion homeostasis 0.000671740182010172 57 16 3 0.1875 0.0526315789473684
GO:BP GO:1903779 regulation of cardiac conduction 0.000735451268311035 59 16 3 0.1875 0.0508474576271186
GO:BP GO:0043299 leukocyte degranulation 0.000746561614026593 535 40 8 0.2 0.0149532710280374
GO:BP GO:0002366 leukocyte activation involved in immune response 0.000800155964446169 717 40 9 0.225 0.0125523012552301
GO:BP GO:0140115 export across plasma membrane 0.000800155964446169 62 16 3 0.1875 0.0483870967741935
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.000808990178124217 547 40 8 0.2 0.0146252285191956
GO:BP GO:0002263 cell activation involved in immune response 0.000808990178124217 721 40 9 0.225 0.0124826629680999
GO:BP GO:1902305 regulation of sodium ion transmembrane transport 0.000808990178124217 63 16 3 0.1875 0.0476190476190476
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.000830706219201127 551 40 8 0.2 0.014519056261343
GO:BP GO:0008104 protein localization 0.000830706219201127 2770 83 28 0.337349397590361 0.0101083032490975
GO:BP GO:0042592 homeostatic process 0.000873614387122662 1981 29 12 0.413793103448276 0.0060575466935891
GO:BP GO:0046903 secretion 0.000911219671849821 1501 81 19 0.234567901234568 0.0126582278481013
GO:BP GO:0010033 response to organic substance 0.000911219671849821 3412 49 22 0.448979591836735 0.00644783118405627
GO:BP GO:0045184 establishment of protein localization 0.000974479351789023 2035 83 23 0.27710843373494 0.0113022113022113
GO:BP GO:0034220 ion transmembrane transport 0.000974479351789023 1397 23 9 0.391304347826087 0.00644237652111668
GO:BP GO:0072657 protein localization to membrane 0.00104157561747557 665 45 9 0.2 0.0135338345864662
GO:BP GO:0006983 ER overload response 0.00111494758934392 12 99 3 0.0303030303030303 0.25
GO:BP GO:0015031 protein transport 0.00129430345844809 1929 83 22 0.265060240963855 0.0114048729911871
GO:BP GO:0006950 response to stress 0.0015508421760637 4170 40 21 0.525 0.00503597122302158
GO:BP GO:0033365 protein localization to organelle 0.00155640855405272 1017 92 16 0.173913043478261 0.015732546705998
GO:BP GO:0006814 sodium ion transport 0.00155886951505378 241 16 4 0.25 0.016597510373444
GO:BP GO:0065008 regulation of biological quality 0.00162289927022414 4131 35 19 0.542857142857143 0.00459937061244251
GO:BP GO:0015833 peptide transport 0.00168827996989634 1971 83 22 0.265060240963855 0.0111618467782851
GO:BP GO:0002376 immune system process 0.00202947989693291 3278 43 19 0.441860465116279 0.00579621720561318
GO:BP GO:0072594 establishment of protein localization to organelle 0.00205518887046366 584 83 11 0.132530120481928 0.0188356164383562
GO:BP GO:0006812 cation transport 0.00206523446716049 1197 23 8 0.347826086956522 0.00668337510442774
GO:BP GO:0042886 amide transport 0.00207194361139258 2007 83 22 0.265060240963855 0.0109616342800199
GO:BP GO:0006874 cellular calcium ion homeostasis 0.00211954727254919 460 29 6 0.206896551724138 0.0130434782608696
GO:BP GO:0034613 cellular protein localization 0.00212297562069988 2014 83 22 0.265060240963855 0.0109235352532274
GO:BP GO:0099587 inorganic ion import across plasma membrane 0.00214007141691986 97 16 3 0.1875 0.0309278350515464
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.00214007141691986 686 125 15 0.12 0.021865889212828
GO:BP GO:0098659 inorganic cation import across plasma membrane 0.00214007141691986 97 16 3 0.1875 0.0309278350515464
GO:BP GO:0070727 cellular macromolecule localization 0.0021860996257294 2024 83 22 0.265060240963855 0.0108695652173913
GO:BP GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response 0.00223463863547421 16 99 3 0.0303030303030303 0.1875
GO:BP GO:0055074 calcium ion homeostasis 0.00227477139186838 472 29 6 0.206896551724138 0.0127118644067797
GO:BP GO:0002274 myeloid leukocyte activation 0.00228576906250768 667 40 8 0.2 0.0119940029985007
GO:BP GO:0055085 transmembrane transport 0.00251114315379616 1635 23 9 0.391304347826087 0.0055045871559633
GO:BP GO:0002443 leukocyte mediated immunity 0.00251114315379616 877 40 9 0.225 0.0102622576966933
GO:BP GO:0032414 positive regulation of ion transmembrane transporter activity 0.00278138406241917 109 16 3 0.1875 0.0275229357798165
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.0028261729941252 497 29 6 0.206896551724138 0.0120724346076459
GO:BP GO:0043067 regulation of programmed cell death 0.00303853631044947 1582 122 24 0.19672131147541 0.0151706700379267
GO:BP GO:0006811 ion transport 0.0032065826312384 3661 23 13 0.565217391304348 0.00355094236547391
GO:BP GO:0033036 macromolecule localization 0.0032065826312384 3218 83 29 0.349397590361446 0.00901180857675575
GO:BP GO:0032411 positive regulation of transporter activity 0.00332972458851021 118 16 3 0.1875 0.0254237288135593
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.00332972458851021 516 29 6 0.206896551724138 0.0116279069767442
GO:BP GO:0098739 import across plasma membrane 0.0033605363211305 163 30 4 0.133333333333333 0.0245398773006135
GO:BP GO:0043462 regulation of ATPase activity 0.00371560344376254 80 62 4 0.0645161290322581 0.05
GO:BP GO:0033554 cellular response to stress 0.00411593542316391 2111 101 25 0.247524752475248 0.0118427285646613
GO:BP GO:0009628 response to abiotic stimulus 0.00412279087387967 1261 31 9 0.290322580645161 0.00713719270420301
GO:BP GO:0042493 response to drug 0.00436643805844527 396 6 3 0.5 0.00757575757575758
GO:BP GO:0042221 response to chemical 0.00439931531025741 4781 49 25 0.510204081632653 0.00522903158335076
GO:BP GO:0032781 positive regulation of ATPase activity 0.00463729894823952 57 37 3 0.0810810810810811 0.0526315789473684
GO:BP GO:0071705 nitrogen compound transport 0.00474772930214977 2322 83 23 0.27710843373494 0.0099052540913006
GO:BP GO:0045639 positive regulation of myeloid cell differentiation 0.00474772930214977 103 21 3 0.142857142857143 0.029126213592233
GO:BP GO:0046466 membrane lipid catabolic process 0.00525056518369924 37 60 3 0.05 0.0810810810810811
GO:BP GO:0036503 ERAD pathway 0.00531206547593055 103 99 5 0.0505050505050505 0.0485436893203883
GO:BP GO:0061337 cardiac conduction 0.00589778362601632 150 16 3 0.1875 0.02
GO:BP GO:1904064 positive regulation of cation transmembrane transport 0.00589778362601632 150 16 3 0.1875 0.02
GO:BP GO:0009100 glycoprotein metabolic process 0.0060316543360029 424 133 11 0.0827067669172932 0.0259433962264151
GO:BP GO:0030433 ubiquitin-dependent ERAD pathway 0.00606466745820325 82 29 3 0.103448275862069 0.0365853658536585
GO:BP GO:0046907 intracellular transport 0.00651623193039203 1767 83 19 0.228915662650602 0.010752688172043
GO:BP GO:0072659 protein localization to plasma membrane 0.006548200998085 283 39 5 0.128205128205128 0.0176678445229682
GO:BP GO:0032469 endoplasmic reticulum calcium ion homeostasis 0.00725779320083121 26 99 3 0.0303030303030303 0.115384615384615
GO:BP GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 0.00739125801456347 131 20 3 0.15 0.0229007633587786
GO:BP GO:0046683 response to organophosphorus 0.00761680803278201 137 46 4 0.0869565217391304 0.0291970802919708
GO:BP GO:0001775 cell activation 0.00803973686281108 1495 55 13 0.236363636363636 0.00869565217391304
GO:BP GO:0010941 regulation of cell death 0.00823754813272606 1720 122 24 0.19672131147541 0.013953488372093
GO:BP GO:0051050 positive regulation of transport 0.00897981430229114 923 21 6 0.285714285714286 0.00650054171180932
GO:BP GO:0045321 leukocyte activation 0.00905063097473715 1332 40 10 0.25 0.00750750750750751
GO:BP GO:0070887 cellular response to chemical stimulus 0.0101130697736698 3393 101 33 0.326732673267327 0.00972590627763042
GO:BP GO:0098657 import into cell 0.010357644152665 235 30 4 0.133333333333333 0.0170212765957447
GO:BP GO:0080135 regulation of cellular response to stress 0.0104132728874346 725 99 12 0.121212121212121 0.016551724137931
GO:BP GO:0014074 response to purine-containing compound 0.0104282160290917 152 46 4 0.0869565217391304 0.0263157894736842
GO:BP GO:0051049 regulation of transport 0.0105431673415838 1809 21 8 0.380952380952381 0.00442233278054174
GO:BP GO:0042981 regulation of apoptotic process 0.0107673774360157 1549 122 22 0.180327868852459 0.0142027114267269
GO:BP GO:1903364 positive regulation of cellular protein catabolic process 0.0107673774360157 154 20 3 0.15 0.0194805194805195
GO:BP GO:0071407 cellular response to organic cyclic compound 0.010850483428042 587 6 3 0.5 0.00511073253833049
GO:BP GO:1900101 regulation of endoplasmic reticulum unfolded protein response 0.0109193914975371 31 99 3 0.0303030303030303 0.0967741935483871
GO:BP GO:0006915 apoptotic process 0.0112101222919996 1990 122 26 0.213114754098361 0.0130653266331658
GO:BP GO:0009101 glycoprotein biosynthetic process 0.011435075413255 347 125 9 0.072 0.0259365994236311
GO:BP GO:0035637 multicellular organismal signaling 0.0117955793341397 204 16 3 0.1875 0.0147058823529412
GO:BP GO:1990778 protein localization to cell periphery 0.0123840137937045 338 39 5 0.128205128205128 0.014792899408284
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.0127907616543447 1853 125 25 0.2 0.0134916351861846
GO:BP GO:0012501 programmed cell death 0.0127907616543447 2143 103 24 0.233009708737864 0.0111992533831078
GO:BP GO:0034767 positive regulation of ion transmembrane transport 0.013519697842112 217 16 3 0.1875 0.0138248847926267
GO:BP GO:0034764 positive regulation of transmembrane transport 0.013519697842112 217 16 3 0.1875 0.0138248847926267
GO:BP GO:0009057 macromolecule catabolic process 0.0141236177676385 1468 132 22 0.166666666666667 0.0149863760217984
GO:BP GO:0006886 intracellular protein transport 0.0142253119235952 1186 83 14 0.168674698795181 0.0118043844856661
GO:BP GO:0071805 potassium ion transmembrane transport 0.0142253119235952 224 16 3 0.1875 0.0133928571428571
GO:BP GO:0043928 exonucleolytic catabolism of deadenylated mRNA 0.0142701404936208 33 106 3 0.0283018867924528 0.0909090909090909
GO:BP GO:0045851 pH reduction 0.0148790576312958 59 60 3 0.05 0.0508474576271186
GO:BP GO:0003006 developmental process involved in reproduction 0.0148790576312958 982 39 8 0.205128205128205 0.00814663951120163
GO:BP GO:0006839 mitochondrial transport 0.0148790576312958 284 73 6 0.0821917808219178 0.0211267605633803
GO:BP GO:0034605 cellular response to heat 0.0150410791056724 118 68 4 0.0588235294117647 0.0338983050847458
GO:BP GO:0044242 cellular lipid catabolic process 0.0150525886585246 232 60 5 0.0833333333333333 0.021551724137931
GO:BP GO:0071396 cellular response to lipid 0.0151497824468083 578 7 3 0.428571428571429 0.00519031141868512
GO:BP GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic 0.0162428801348168 35 106 3 0.0283018867924528 0.0857142857142857
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0169330151272676 4439 9 7 0.777777777777778 0.00157693174138319
GO:BP GO:0006813 potassium ion transport 0.0179509597170736 249 16 3 0.1875 0.0120481927710843
GO:BP GO:0008016 regulation of heart contraction 0.0184890391536673 254 16 3 0.1875 0.0118110236220472
GO:BP GO:0044706 multi-multicellular organism process 0.0189079345999766 227 39 4 0.102564102564103 0.0176211453744493
GO:BP GO:0006790 sulfur compound metabolic process 0.0197197521122124 386 79 7 0.0886075949367089 0.0181347150259067
GO:BP GO:0090150 establishment of protein localization to membrane 0.0197884221396964 351 26 4 0.153846153846154 0.0113960113960114
GO:BP GO:0030155 regulation of cell adhesion 0.0202407620611053 748 13 4 0.307692307692308 0.0053475935828877
GO:BP GO:0044257 cellular protein catabolic process 0.0203661051494335 813 99 12 0.121212121212121 0.014760147601476
GO:BP GO:0032412 regulation of ion transmembrane transporter activity 0.0203661051494335 270 16 3 0.1875 0.0111111111111111
GO:BP GO:0009266 response to temperature stimulus 0.0203661051494335 228 40 4 0.1 0.0175438596491228
GO:BP GO:0050790 regulation of catalytic activity 0.0203993354462432 2545 43 14 0.325581395348837 0.00550098231827112
GO:BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 0.0213859022243596 221 20 3 0.15 0.0135746606334842
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0215543324610245 1145 133 18 0.135338345864662 0.0157205240174672
GO:BP GO:0022898 regulation of transmembrane transporter activity 0.0215543324610245 281 16 3 0.1875 0.0106761565836299
GO:BP GO:0002252 immune effector process 0.0221034488573738 1309 40 9 0.225 0.00687547746371276
GO:BP GO:1901700 response to oxygen-containing compound 0.0222939135996496 1739 49 12 0.244897959183673 0.00690051753881541
GO:BP GO:0051591 response to cAMP 0.0224689475089103 97 98 4 0.0408163265306122 0.0412371134020619
GO:BP GO:0060047 heart contraction 0.0225090758380975 288 16 3 0.1875 0.0104166666666667
GO:BP GO:0030163 protein catabolic process 0.022547193524113 974 132 16 0.121212121212121 0.0164271047227926
GO:BP GO:0051235 maintenance of location 0.022547193524113 337 29 4 0.137931034482759 0.0118694362017804
GO:BP GO:0008219 cell death 0.0227320985192139 2292 103 24 0.233009708737864 0.0104712041884817
GO:BP GO:0032409 regulation of transporter activity 0.0235005789632486 297 16 3 0.1875 0.0101010101010101
GO:BP GO:0044265 cellular macromolecule catabolic process 0.0235005789632486 1231 106 16 0.150943396226415 0.0129975629569456
GO:BP GO:0003015 heart process 0.0235383366116391 298 16 3 0.1875 0.0100671140939597
GO:BP GO:0061024 membrane organization 0.0236072515313425 973 26 6 0.230769230769231 0.00616649537512847
GO:BP GO:0045732 positive regulation of protein catabolic process 0.0236072515313425 237 20 3 0.15 0.0126582278481013
GO:BP GO:0048608 reproductive structure development 0.0236072515313425 429 39 5 0.128205128205128 0.0116550116550117
GO:BP GO:1903522 regulation of blood circulation 0.0236141309438506 301 16 3 0.1875 0.00996677740863787
GO:BP GO:0061458 reproductive system development 0.0239054270548251 432 39 5 0.128205128205128 0.0115740740740741
GO:BP GO:0010243 response to organonitrogen compound 0.0240745417303607 1085 49 9 0.183673469387755 0.00829493087557604
GO:BP GO:0044057 regulation of system process 0.0243882209383748 623 17 4 0.235294117647059 0.00642054574638844
GO:BP GO:2000677 regulation of transcription regulatory region DNA binding 0.0245435693596106 52 92 3 0.0326086956521739 0.0576923076923077
GO:BP GO:0050896 response to stimulus 0.024847766871048 9407 40 30 0.75 0.00318911448921016
GO:BP GO:0009408 response to heat 0.0257646735605274 159 31 3 0.0967741935483871 0.0188679245283019
GO:BP GO:0071702 organic substance transport 0.0262279382330416 2766 83 23 0.27710843373494 0.00831525668835864
GO:BP GO:0045454 cell redox homeostasis 0.0262279382330416 58 85 3 0.0352941176470588 0.0517241379310345
GO:BP GO:0006749 glutathione metabolic process 0.0264985595839424 63 79 3 0.0379746835443038 0.0476190476190476
GO:BP GO:0014070 response to organic cyclic compound 0.0265806840257145 967 6 3 0.5 0.0031023784901758
GO:BP GO:0043270 positive regulation of ion transport 0.0265806840257145 694 16 4 0.25 0.00576368876080692
GO:BP GO:1903362 regulation of cellular protein catabolic process 0.0265806840257145 257 20 3 0.15 0.0116731517509728
GO:BP GO:0044248 cellular catabolic process 0.0266696312203178 2347 132 29 0.21969696969697 0.0123561994034938
GO:BP GO:0010332 response to gamma radiation 0.0266696312203178 55 92 3 0.0326086956521739 0.0545454545454545
GO:BP GO:0007155 cell adhesion 0.0266696312203178 1492 13 5 0.384615384615385 0.00335120643431635
GO:BP GO:0022610 biological adhesion 0.0270565786975986 1499 13 5 0.384615384615385 0.00333555703802535
GO:BP GO:1903708 positive regulation of hemopoiesis 0.0274632420155605 157 33 3 0.0909090909090909 0.0191082802547771
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.0274632420155605 157 33 3 0.0909090909090909 0.0191082802547771
GO:BP GO:0071479 cellular response to ionizing radiation 0.0279124593189308 69 75 3 0.04 0.0434782608695652
GO:BP GO:0032879 regulation of localization 0.0280549689511385 2872 21 9 0.428571428571429 0.00313370473537604
GO:BP GO:1900034 regulation of cellular response to heat 0.0293795368786589 79 68 3 0.0441176470588235 0.0379746835443038
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.0295210430900714 263 21 3 0.142857142857143 0.0114068441064639
GO:BP GO:0007568 aging 0.0295210430900714 329 17 3 0.176470588235294 0.00911854103343465
GO:BP GO:0051101 regulation of DNA binding 0.0295210430900714 121 92 4 0.0434782608695652 0.0330578512396694
GO:BP GO:0045862 positive regulation of proteolysis 0.0295210430900714 378 30 4 0.133333333333333 0.0105820105820106
GO:BP GO:0045785 positive regulation of cell adhesion 0.0295210430900714 437 13 3 0.230769230769231 0.0068649885583524
GO:BP GO:0046718 viral entry into host cell 0.0300558421783389 141 39 3 0.0769230769230769 0.0212765957446809
GO:BP GO:1904062 regulation of cation transmembrane transport 0.0311803994794496 360 16 3 0.1875 0.00833333333333333
GO:BP GO:0030001 metal ion transport 0.0318493489938092 514 23 4 0.173913043478261 0.00778210116731518
GO:BP GO:0022414 reproductive process 0.0321306205437246 1493 39 9 0.230769230769231 0.00602813127930342
GO:BP GO:0070482 response to oxygen levels 0.0321419703203763 408 29 4 0.137931034482759 0.00980392156862745
GO:BP GO:0030641 regulation of cellular pH 0.0321419703203763 95 60 3 0.05 0.0315789473684211
GO:BP GO:1901698 response to nitrogen compound 0.0321419703203763 1172 49 9 0.183673469387755 0.00767918088737201
GO:BP GO:0000003 reproduction 0.0321419703203763 1496 39 9 0.230769230769231 0.00601604278074866
GO:BP GO:0033993 response to lipid 0.0322880519747559 918 7 3 0.428571428571429 0.00326797385620915
GO:BP GO:0090398 cellular senescence 0.0342819427389092 79 75 3 0.04 0.0379746835443038
GO:BP GO:1901564 organonitrogen compound metabolic process 0.0342819427389092 6792 60 33 0.55 0.00485865724381625
GO:BP GO:0051270 regulation of cellular component movement 0.0342989015102685 1141 6 3 0.5 0.00262927256792287
GO:BP GO:0044409 entry into host 0.0346908919818657 154 39 3 0.0769230769230769 0.0194805194805195
GO:BP GO:0043069 negative regulation of programmed cell death 0.0346908919818657 943 73 10 0.136986301369863 0.0106044538706257
GO:BP GO:0006820 anion transport 0.0348419435881324 2889 83 23 0.27710843373494 0.00796123226029768
GO:BP GO:0051336 regulation of hydrolase activity 0.0348419435881324 1321 37 8 0.216216216216216 0.0060560181680545
GO:BP GO:0071495 cellular response to endogenous stimulus 0.0348419435881324 1422 21 6 0.285714285714286 0.00421940928270042
GO:BP GO:0030522 intracellular receptor signaling pathway 0.0348419435881324 284 98 6 0.0612244897959184 0.0211267605633803
GO:BP GO:0006493 protein O-linked glycosylation 0.0357872240510562 102 120 4 0.0333333333333333 0.0392156862745098
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0357872240510562 783 37 6 0.162162162162162 0.00766283524904215
GO:BP GO:0046034 ATP metabolic process 0.0357872240510562 314 20 3 0.15 0.00955414012738853
GO:BP GO:0000041 transition metal ion transport 0.0358229761832149 129 95 4 0.0421052631578947 0.0310077519379845
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.036110519717077 434 29 4 0.137931034482759 0.00921658986175115
GO:BP GO:0006885 regulation of pH 0.0361325130826388 103 60 3 0.05 0.029126213592233
GO:BP GO:0051239 regulation of multicellular organismal process 0.0377197663024067 2861 39 13 0.333333333333333 0.00454386578119539
GO:BP GO:0043269 regulation of ion transport 0.0383723687929179 1379 16 5 0.3125 0.00362581580855693
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 0.0393104146345194 750 40 6 0.15 0.008
GO:BP GO:0019058 viral life cycle 0.0394928411388004 353 59 5 0.0847457627118644 0.0141643059490085
GO:BP GO:0042391 regulation of membrane potential 0.0394928411388004 442 30 4 0.133333333333333 0.00904977375565611
GO:BP GO:0032870 cellular response to hormone stimulus 0.0399554071450831 645 21 4 0.19047619047619 0.0062015503875969
GO:BP GO:0016042 lipid catabolic process 0.0400983713556113 349 60 5 0.0833333333333333 0.0143266475644699
GO:BP GO:0009566 fertilization 0.0403236057171745 198 34 3 0.0882352941176471 0.0151515151515152
GO:BP GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum 0.0416678007338097 87 78 3 0.0384615384615385 0.0344827586206897
GO:BP GO:0006626 protein targeting to mitochondrion 0.0419725749322169 101 68 3 0.0441176470588235 0.0297029702970297
GO:BP GO:0002684 positive regulation of immune system process 0.0419725749322169 1065 21 5 0.238095238095238 0.00469483568075117
GO:BP GO:0052126 movement in host environment 0.0419725749322169 177 39 3 0.0769230769230769 0.0169491525423729
GO:BP GO:0010212 response to ionizing radiation 0.04200079992913 146 92 4 0.0434782608695652 0.0273972602739726
GO:BP GO:0043413 macromolecule glycosylation 0.04200079992913 251 120 6 0.05 0.0239043824701195
GO:BP GO:0006486 protein glycosylation 0.04200079992913 251 120 6 0.05 0.0239043824701195
GO:BP GO:0002576 platelet degranulation 0.0421187614702502 126 55 3 0.0545454545454545 0.0238095238095238
GO:BP GO:0016485 protein processing 0.0434118168529777 235 92 5 0.0543478260869565 0.0212765957446809
GO:BP GO:0021510 spinal cord development 0.0438834582200087 104 68 3 0.0441176470588235 0.0288461538461538
GO:BP GO:0043603 cellular amide metabolic process 0.0438926258253005 1241 60 10 0.166666666666667 0.008058017727639
GO:BP GO:1903706 regulation of hemopoiesis 0.0438926258253005 424 33 4 0.121212121212121 0.00943396226415094
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0438926258253005 363 20 3 0.15 0.00826446280991736
GO:BP GO:0065002 intracellular protein transmembrane transport 0.0438926258253005 52 137 3 0.0218978102189781 0.0576923076923077
GO:BP GO:0019438 aromatic compound biosynthetic process 0.0440733522700765 4278 9 6 0.666666666666667 0.00140252454417952
GO:BP GO:0010498 proteasomal protein catabolic process 0.0440733522700765 491 29 4 0.137931034482759 0.00814663951120163
GO:BP GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway 0.0440733522700765 78 92 3 0.0326086956521739 0.0384615384615385
GO:BP GO:0007005 mitochondrion organization 0.0440733522700765 561 73 7 0.0958904109589041 0.0124777183600713
GO:BP GO:0018130 heterocycle biosynthetic process 0.0440733522700765 4269 9 6 0.666666666666667 0.00140548137737175
GO:BP GO:0044249 cellular biosynthetic process 0.0442649108837457 6154 7 6 0.857142857142857 0.00097497562560936
GO:BP GO:0061448 connective tissue development 0.0446435399560684 256 122 6 0.0491803278688525 0.0234375
GO:BP GO:0044272 sulfur compound biosynthetic process 0.0446435399560684 193 115 5 0.0434782608695652 0.0259067357512953
GO:BP GO:0061912 selective autophagy 0.0448219230641586 63 117 3 0.0256410256410256 0.0476190476190476
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0448219230641586 6201 7 6 0.857142857142857 0.000967585873246251
GO:BP GO:0016236 macroautophagy 0.0451465273715224 312 72 5 0.0694444444444444 0.016025641025641
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0455787286165579 745 85 9 0.105882352941176 0.0120805369127517
GO:BP GO:0051216 cartilage development 0.0459923750650161 196 115 5 0.0434782608695652 0.0255102040816327
GO:BP GO:1901576 organic substance biosynthetic process 0.0459923750650161 6248 7 6 0.857142857142857 0.000960307298335467
GO:BP GO:0070085 glycosylation 0.0459929721175311 264 120 6 0.05 0.0227272727272727
GO:BP GO:0002682 regulation of immune system process 0.046161247096717 1617 21 6 0.285714285714286 0.00371057513914657
GO:BP GO:0044255 cellular lipid metabolic process 0.0463096849527297 1075 60 9 0.15 0.00837209302325581
GO:BP GO:0060548 negative regulation of cell death 0.0463096849527297 1038 73 10 0.136986301369863 0.00963391136801541
GO:BP GO:0071704 organic substance metabolic process 0.0469905292666437 11326 15 14 0.933333333333333 0.00123609394313968
GO:BP GO:0007565 female pregnancy 0.0470675586551262 198 39 3 0.0769230769230769 0.0151515151515152
GO:BP GO:0031331 positive regulation of cellular catabolic process 0.0470675586551262 393 20 3 0.15 0.00763358778625954
GO:BP GO:0048609 multicellular organismal reproductive process 0.0471108215287089 845 39 6 0.153846153846154 0.00710059171597633
GO:BP GO:0009058 biosynthetic process 0.0476422684273265 6340 7 6 0.857142857142857 0.000946372239747634
GO:BP GO:0042176 regulation of protein catabolic process 0.0486524303435468 401 20 3 0.15 0.00748129675810474
GO:BP GO:0071310 cellular response to organic substance 0.049098226280387 2776 21 8 0.380952380952381 0.00288184438040346
GO:BP GO:0014706 striated muscle tissue development 0.0491028060451799 380 140 8 0.0571428571428571 0.0210526315789474
GO:BP GO:0050900 leukocyte migration 0.0491582177436946 511 16 3 0.1875 0.00587084148727984
GO:BP GO:0098869 cellular oxidant detoxification 0.0492271744212275 100 79 3 0.0379746835443038 0.03
GO:BP GO:1901565 organonitrogen compound catabolic process 0.0492557640448937 1358 75 12 0.16 0.00883652430044183
GO:BP GO:0030162 regulation of proteolysis 0.0496093496851415 752 32 5 0.15625 0.00664893617021277
GO:CC GO:0005783 endoplasmic reticulum 2.75525776092054e-18 1982 87 44 0.505747126436782 0.0221997981836529
GO:CC GO:0031984 organelle subcompartment 6.56391092264669e-18 1773 120 49 0.408333333333333 0.0276367738296672
GO:CC GO:0098827 endoplasmic reticulum subcompartment 6.56391092264669e-18 1122 120 40 0.333333333333333 0.035650623885918
GO:CC GO:0005789 endoplasmic reticulum membrane 6.74419064363891e-18 1117 87 34 0.390804597701149 0.0304386750223814
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 6.74419064363891e-18 1139 120 40 0.333333333333333 0.0351185250219491
GO:CC GO:0031090 organelle membrane 8.41177763852903e-17 3612 87 54 0.620689655172414 0.0149501661129568
GO:CC GO:0012505 endomembrane system 1.43955414709814e-16 4640 87 60 0.689655172413793 0.0129310344827586
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 2.70906187889735e-12 128 117 14 0.11965811965812 0.109375
GO:CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 2.80081321175465e-10 131 78 11 0.141025641025641 0.083969465648855
GO:CC GO:0016020 membrane 4.24656079824078e-10 9838 87 75 0.862068965517241 0.00762350071152673
GO:CC GO:0097708 intracellular vesicle 4.24656079824078e-10 2428 70 32 0.457142857142857 0.0131795716639209
GO:CC GO:0031410 cytoplasmic vesicle 4.24656079824078e-10 2424 70 32 0.457142857142857 0.0132013201320132
GO:CC GO:0043227 membrane-bounded organelle 4.24656079824078e-10 12858 120 112 0.933333333333333 0.00871053040908384
GO:CC GO:0031982 vesicle 4.24656079824078e-10 4055 67 40 0.597014925373134 0.00986436498150432
GO:CC GO:0070062 extracellular exosome 1.97617328689986e-09 2176 60 27 0.45 0.0124080882352941
GO:CC GO:1903561 extracellular vesicle 4.2933405084072e-09 2261 60 27 0.45 0.0119416187527643
GO:CC GO:0043230 extracellular organelle 4.2933405084072e-09 2263 60 27 0.45 0.0119310649580203
GO:CC GO:0005788 endoplasmic reticulum lumen 1.46763352768344e-08 307 135 16 0.118518518518519 0.0521172638436482
GO:CC GO:0043231 intracellular membrane-bounded organelle 2.81533339299591e-08 11296 120 102 0.85 0.00902974504249292
GO:CC GO:0016021 integral component of membrane 5.47360384526627e-08 5711 87 53 0.609195402298851 0.00928033619331115
GO:CC GO:0005737 cytoplasm 8.27827839673806e-08 11911 95 85 0.894736842105263 0.00713626059944589
GO:CC GO:0043226 organelle 9.67544229311362e-08 14008 142 132 0.929577464788732 0.00942318675042833
GO:CC GO:0031224 intrinsic component of membrane 1.36323228870565e-07 5868 87 53 0.609195402298851 0.00903203817314247
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 1.74467665302488e-07 158 99 10 0.101010101010101 0.0632911392405063
GO:CC GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 1.74467665302488e-07 74 70 7 0.1 0.0945945945945946
GO:CC GO:0031301 integral component of organelle membrane 1.90349043335411e-07 382 99 14 0.141414141414141 0.0366492146596859
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 2.55381182008814e-07 166 99 10 0.101010101010101 0.0602409638554217
GO:CC GO:0098588 bounding membrane of organelle 2.66836347686101e-07 2158 103 33 0.320388349514563 0.015291936978684
GO:CC GO:0048770 pigment granule 3.26631438688665e-07 105 85 8 0.0941176470588235 0.0761904761904762
GO:CC GO:0042470 melanosome 3.26631438688665e-07 105 85 8 0.0941176470588235 0.0761904761904762
GO:CC GO:0031300 intrinsic component of organelle membrane 4.25017461067106e-07 413 99 14 0.141414141414141 0.0338983050847458
GO:CC GO:0005615 extracellular space 5.73784043923342e-07 3594 42 24 0.571428571428571 0.00667779632721202
GO:CC GO:0005790 smooth endoplasmic reticulum 1.36233266504073e-06 34 6 3 0.5 0.0882352941176471
GO:CC GO:0005890 sodium:potassium-exchanging ATPase complex 1.36233266504073e-06 12 16 3 0.1875 0.25
GO:CC GO:0098533 ATPase dependent transmembrane transport complex 4.89351418787306e-06 18 16 3 0.1875 0.166666666666667
GO:CC GO:0098796 membrane protein complex 5.4201091742386e-06 1322 21 10 0.476190476190476 0.0075642965204236
GO:CC GO:0005794 Golgi apparatus 6.46425173921014e-06 1623 125 29 0.232 0.0178681454097351
GO:CC GO:0005787 signal peptidase complex 9.07509375471682e-06 5 83 3 0.036144578313253 0.6
GO:CC GO:0030141 secretory granule 1.07378766400951e-05 851 40 11 0.275 0.0129259694477086
GO:CC GO:0005576 extracellular region 1.07515814701575e-05 4567 42 25 0.595238095238095 0.00547405298883293
GO:CC GO:0005775 vacuolar lumen 1.30344248805131e-05 174 60 7 0.116666666666667 0.0402298850574713
GO:CC GO:0043229 intracellular organelle 1.9852458548694e-05 12491 120 102 0.85 0.0081658794331919
GO:CC GO:0071682 endocytic vesicle lumen 3.59559218666873e-05 20 29 3 0.103448275862069 0.15
GO:CC GO:0033018 sarcoplasmic reticulum lumen 4.84805219731184e-05 10 67 3 0.0447761194029851 0.3
GO:CC GO:0070161 anchoring junction 4.97550367396836e-05 836 39 10 0.256410256410256 0.0119617224880383
GO:CC GO:0099503 secretory vesicle 5.27900394711651e-05 1020 40 11 0.275 0.0107843137254902
GO:CC GO:0005773 vacuole 6.51102217487712e-05 810 70 13 0.185714285714286 0.0160493827160494
GO:CC GO:0000323 lytic vacuole 9.04689377432977e-05 712 70 12 0.171428571428571 0.0168539325842697
GO:CC GO:0005764 lysosome 9.04689377432977e-05 712 70 12 0.171428571428571 0.0168539325842697
GO:CC GO:0034663 endoplasmic reticulum chaperone complex 9.1492003970196e-05 9 97 3 0.0309278350515464 0.333333333333333
GO:CC GO:0005622 intracellular anatomical structure 0.00014770341235704 14790 120 111 0.925 0.00750507099391481
GO:CC GO:0044233 mitochondria-associated endoplasmic reticulum membrane 0.000147913443354511 20 49 3 0.0612244897959184 0.15
GO:CC GO:0005925 focal adhesion 0.000167995642080453 420 39 7 0.179487179487179 0.0166666666666667
GO:CC GO:0042582 azurophil granule 0.000173501166880417 154 70 6 0.0857142857142857 0.038961038961039
GO:CC GO:0005766 primary lysosome 0.000173501166880417 154 70 6 0.0857142857142857 0.038961038961039
GO:CC GO:0030055 cell-substrate junction 0.00017679113508172 427 39 7 0.179487179487179 0.0163934426229508
GO:CC GO:0008180 COP9 signalosome 0.00018816148242511 35 31 3 0.0967741935483871 0.0857142857142857
GO:CC GO:0016469 proton-transporting two-sector ATPase complex 0.000207171993485945 54 21 3 0.142857142857143 0.0555555555555556
GO:CC GO:0035578 azurophil granule lumen 0.000289098830741015 91 40 4 0.1 0.043956043956044
GO:CC GO:0005901 caveola 0.000310846048015312 83 16 3 0.1875 0.036144578313253
GO:CC GO:0071944 cell periphery 0.000425497895865579 6169 33 22 0.666666666666667 0.00356621818771276
GO:CC GO:0030667 secretory granule membrane 0.000482652748203838 303 86 8 0.0930232558139535 0.0264026402640264
GO:CC GO:0098791 Golgi apparatus subcompartment 0.000482652748203838 885 125 17 0.136 0.0192090395480226
GO:CC GO:0030312 external encapsulating structure 0.000510884074138988 563 36 7 0.194444444444444 0.0124333925399645
GO:CC GO:0031012 extracellular matrix 0.000510884074138988 562 36 7 0.194444444444444 0.0124555160142349
GO:CC GO:0098857 membrane microdomain 0.000559036433714002 335 60 7 0.116666666666667 0.0208955223880597
GO:CC GO:0045121 membrane raft 0.000559036433714002 335 60 7 0.116666666666667 0.0208955223880597
GO:CC GO:1904949 ATPase complex 0.000592917748660884 108 16 3 0.1875 0.0277777777777778
GO:CC GO:0001669 acrosomal vesicle 0.000627494236578797 119 39 4 0.102564102564103 0.0336134453781513
GO:CC GO:0044853 plasma membrane raft 0.000702537448148605 116 16 3 0.1875 0.0258620689655172
GO:CC GO:0036126 sperm flagellum 0.000702537448148605 116 16 3 0.1875 0.0258620689655172
GO:CC GO:0062023 collagen-containing extracellular matrix 0.000752710720920357 421 36 6 0.166666666666667 0.0142517814726841
GO:CC GO:0044232 organelle membrane contact site 0.000804958853682854 39 49 3 0.0612244897959184 0.0769230769230769
GO:CC GO:0097729 9+2 motile cilium 0.000839298815157222 126 16 3 0.1875 0.0238095238095238
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00109534398446539 779 86 12 0.13953488372093 0.0154043645699615
GO:CC GO:0030867 rough endoplasmic reticulum membrane 0.0011248133152403 29 76 3 0.0394736842105263 0.103448275862069
GO:CC GO:0043202 lysosomal lumen 0.001314227735744 97 60 4 0.0666666666666667 0.0412371134020619
GO:CC GO:0012506 vesicle membrane 0.001314227735744 800 86 12 0.13953488372093 0.015
GO:CC GO:0101031 chaperone complex 0.00172573867902718 27 97 3 0.0309278350515464 0.111111111111111
GO:CC GO:0000139 Golgi membrane 0.00184968366866294 771 80 11 0.1375 0.0142671854734112
GO:CC GO:0032991 protein-containing complex 0.0019967548667325 5548 21 14 0.666666666666667 0.00252343186733958
GO:CC GO:0034774 secretory granule lumen 0.0025085336074156 320 40 5 0.125 0.015625
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.00262540191372007 324 40 5 0.125 0.0154320987654321
GO:CC GO:0031983 vesicle lumen 0.00267091593235473 326 40 5 0.125 0.0153374233128834
GO:CC GO:0031514 motile cilium 0.00282794983228463 205 16 3 0.1875 0.0146341463414634
GO:CC GO:0030054 cell junction 0.00308195945879551 2105 8 5 0.625 0.00237529691211401
GO:CC GO:0070013 intracellular organelle lumen 0.00427452551792408 5402 142 58 0.408450704225352 0.0107367641614217
GO:CC GO:0030139 endocytic vesicle 0.00474033990284803 306 29 4 0.137931034482759 0.0130718954248366
GO:CC GO:0043233 organelle lumen 0.00497701121976009 5565 142 59 0.415492957746479 0.0106019766397125
GO:CC GO:0031974 membrane-enclosed lumen 0.00497701121976009 5565 142 59 0.415492957746479 0.0106019766397125
GO:CC GO:0030670 phagocytic vesicle membrane 0.00545185951374168 76 55 3 0.0545454545454545 0.0394736842105263
GO:CC GO:0016529 sarcoplasmic reticulum 0.00740143121478583 70 67 3 0.0447761194029851 0.0428571428571429
GO:CC GO:0005791 rough endoplasmic reticulum 0.00817748258149774 86 120 4 0.0333333333333333 0.0465116279069767
GO:CC GO:1902495 transmembrane transporter complex 0.008832988488661 325 16 3 0.1875 0.00923076923076923
GO:CC GO:0005886 plasma membrane 0.00885445998938238 5681 21 13 0.619047619047619 0.0022883295194508
GO:CC GO:0005739 mitochondrion 0.00939523967012099 1673 4 3 0.75 0.0017931858936043
GO:CC GO:1990351 transporter complex 0.00978428840673002 340 16 3 0.1875 0.00882352941176471
GO:CC GO:0016528 sarcoplasm 0.00992628661587279 79 67 3 0.0447761194029851 0.0379746835443038
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 0.0112365687179311 90 62 3 0.0483870967741935 0.0333333333333333
GO:CC GO:0045335 phagocytic vesicle 0.0116272647470218 137 85 4 0.0470588235294118 0.0291970802919708
GO:CC GO:0031967 organelle envelope 0.0158662274001907 1237 6 3 0.5 0.00242522231204527
GO:CC GO:1902494 catalytic complex 0.0158662274001907 1441 10 4 0.4 0.00277585010409438
GO:CC GO:0031975 envelope 0.0158662274001907 1237 6 3 0.5 0.00242522231204527
GO:CC GO:0098797 plasma membrane protein complex 0.0204393648170036 694 21 4 0.19047619047619 0.00576368876080692
GO:CC GO:0005768 endosome 0.021569886146777 987 66 9 0.136363636363636 0.00911854103343465
GO:CC GO:0101002 ficolin-1-rich granule 0.0239788654248541 184 81 4 0.0493827160493827 0.0217391304347826
GO:CC GO:1905368 peptidase complex 0.025484957917041 96 83 3 0.036144578313253 0.03125
GO:CC GO:0120025 plasma membrane bounded cell projection 0.0259594686582887 2229 8 4 0.5 0.00179452669358457
GO:CC GO:0005887 integral component of plasma membrane 0.0267215316227164 1645 16 5 0.3125 0.00303951367781155
GO:CC GO:0042995 cell projection 0.0290617978668223 2330 8 4 0.5 0.00171673819742489
GO:CC GO:0048471 perinuclear region of cytoplasm 0.02919437858548 735 35 5 0.142857142857143 0.00680272108843537
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0309880497206387 1726 16 5 0.3125 0.00289687137891078
GO:CC GO:0098590 plasma membrane region 0.032463317248744 1240 8 3 0.375 0.00241935483870968
GO:CC GO:0030135 coated vesicle 0.039664406166206 295 62 4 0.0645161290322581 0.0135593220338983
GO:CC GO:0005929 cilium 0.0425860750689907 672 16 3 0.1875 0.00446428571428571
GO:CC GO:0010008 endosome membrane 0.0425860750689907 505 57 5 0.087719298245614 0.0099009900990099
GO:MF GO:0051082 unfolded protein binding 2.55855311843062e-07 112 49 8 0.163265306122449 0.0714285714285714
GO:MF GO:0051787 misfolded protein binding 8.83505747420199e-07 28 40 5 0.125 0.178571428571429
GO:MF GO:0005391 P-type sodium:potassium-exchanging ATPase activity 1.102032556926e-05 10 16 3 0.1875 0.3
GO:MF GO:0140358 P-type transmembrane transporter activity 1.51371267921778e-05 12 16 3 0.1875 0.25
GO:MF GO:0044183 protein folding chaperone 3.36244383110032e-05 35 31 4 0.129032258064516 0.114285714285714
GO:MF GO:0051087 chaperone binding 8.07333378666152e-05 103 137 8 0.0583941605839416 0.0776699029126214
GO:MF GO:0060590 ATPase regulator activity 0.000512085088687268 44 16 3 0.1875 0.0681818181818182
GO:MF GO:0042626 ATPase-coupled transmembrane transporter activity 0.00149957116036231 67 16 3 0.1875 0.0447761194029851
GO:MF GO:0015037 peptide disulfide oxidoreductase activity 0.00149957116036231 13 85 3 0.0352941176470588 0.230769230769231
GO:MF GO:0015399 primary active transmembrane transporter activity 0.00172722601887355 74 16 3 0.1875 0.0405405405405405
GO:MF GO:0015036 disulfide oxidoreductase activity 0.00173415107691279 41 85 4 0.0470588235294118 0.0975609756097561
GO:MF GO:0022890 inorganic cation transmembrane transporter activity 0.00278661423497808 591 23 6 0.260869565217391 0.0101522842639594
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.00342286765756035 283 120 9 0.075 0.0318021201413428
GO:MF GO:0008324 cation transmembrane transporter activity 0.00343485053853398 639 23 6 0.260869565217391 0.00938967136150235
GO:MF GO:0016887 ATPase activity 0.00436713061141871 488 31 6 0.193548387096774 0.0122950819672131
GO:MF GO:0016667 oxidoreductase activity, acting on a sulfur group of donors 0.00505935739657911 60 85 4 0.0470588235294118 0.0666666666666667
GO:MF GO:0019899 enzyme binding 0.00543553783370669 2074 21 9 0.428571428571429 0.00433944069431051
GO:MF GO:0031625 ubiquitin protein ligase binding 0.00543553783370669 296 35 5 0.142857142857143 0.0168918918918919
GO:MF GO:0044877 protein-containing complex binding 0.00543553783370669 1287 14 6 0.428571428571429 0.00466200466200466
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.00599826284619618 314 99 8 0.0808080808080808 0.0254777070063694
GO:MF GO:0015081 sodium ion transmembrane transporter activity 0.00599826284619618 151 16 3 0.1875 0.0198675496688742
GO:MF GO:0030246 carbohydrate binding 0.00599826284619618 275 39 5 0.128205128205128 0.0181818181818182
GO:MF GO:0015079 potassium ion transmembrane transporter activity 0.00643710622793988 161 16 3 0.1875 0.0186335403726708
GO:MF GO:0016758 transferase activity, transferring hexosyl groups 0.00692743171457901 205 120 7 0.0583333333333333 0.0341463414634146
GO:MF GO:0015318 inorganic molecular entity transmembrane transporter activity 0.0071749839366086 831 23 6 0.260869565217391 0.0072202166064982
GO:MF GO:0008378 galactosyltransferase activity 0.0071749839366086 24 120 3 0.025 0.125
GO:MF GO:0140272 exogenous protein binding 0.0076062908133044 77 39 3 0.0769230769230769 0.038961038961039
GO:MF GO:0031072 heat shock protein binding 0.0076062908133044 127 98 5 0.0510204081632653 0.0393700787401575
GO:MF GO:0001618 virus receptor activity 0.0076062908133044 76 39 3 0.0769230769230769 0.0394736842105263
GO:MF GO:0045296 cadherin binding 0.00811083277675656 333 39 5 0.128205128205128 0.015015015015015
GO:MF GO:0046983 protein dimerization activity 0.00811083277675656 1069 8 4 0.5 0.00374181478016838
GO:MF GO:0022853 active ion transmembrane transporter activity 0.00936805600577337 213 16 3 0.1875 0.0140845070422535
GO:MF GO:0050839 cell adhesion molecule binding 0.010162451865116 546 39 6 0.153846153846154 0.010989010989011
GO:MF GO:0015075 ion transmembrane transporter activity 0.010162451865116 956 23 6 0.260869565217391 0.00627615062761506
GO:MF GO:0051117 ATPase binding 0.0118874865952962 86 99 4 0.0404040404040404 0.0465116279069767
GO:MF GO:0042277 peptide binding 0.0136941395430784 314 49 5 0.102040816326531 0.0159235668789809
GO:MF GO:0022857 transmembrane transporter activity 0.0151246114350583 1075 23 6 0.260869565217391 0.00558139534883721
GO:MF GO:0046873 metal ion transmembrane transporter activity 0.0167162938399712 435 23 4 0.173913043478261 0.00919540229885057
GO:MF GO:0005509 calcium ion binding 0.0167162938399712 721 7 3 0.428571428571429 0.00416088765603329
GO:MF GO:0017111 nucleoside-triphosphatase activity 0.0168995941776587 872 20 5 0.25 0.00573394495412844
GO:MF GO:0022804 active transmembrane transporter activity 0.0190234688730267 312 16 3 0.1875 0.00961538461538462
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0193845992668535 930 20 5 0.25 0.00537634408602151
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.0193845992668535 930 20 5 0.25 0.00537634408602151
GO:MF GO:0005215 transporter activity 0.0193845992668535 1185 23 6 0.260869565217391 0.00506329113924051
GO:MF GO:0016462 pyrophosphatase activity 0.0193845992668535 928 20 5 0.25 0.00538793103448276
GO:MF GO:0033218 amide binding 0.0232971397681363 389 49 5 0.102040816326531 0.012853470437018
GO:MF GO:0016787 hydrolase activity 0.0256244665679226 2615 20 8 0.4 0.00305927342256214
GO:MF GO:0030234 enzyme regulator activity 0.0268208805925466 1248 48 9 0.1875 0.00721153846153846
GO:MF GO:0052689 carboxylic ester hydrolase activity 0.0295290544087402 146 44 3 0.0681818181818182 0.0205479452054795
GO:MF GO:0016209 antioxidant activity 0.0337597090660006 87 79 3 0.0379746835443038 0.0344827586206897
GO:MF GO:0016491 oxidoreductase activity 0.0403148415988 771 85 9 0.105882352941176 0.0116731517509728
GO:MF GO:0046872 metal ion binding 0.0403148415988 4260 7 5 0.714285714285714 0.00117370892018779
GO:MF GO:0004857 enzyme inhibitor activity 0.0411882945447954 385 40 4 0.1 0.0103896103896104
GO:MF GO:0043169 cation binding 0.0412999075375206 4351 7 5 0.714285714285714 0.00114916111238796
GO:MF GO:0060589 nucleoside-triphosphatase regulator activity 0.0417610110982304 530 16 3 0.1875 0.00566037735849057
GO:MF GO:0005524 ATP binding 0.0430084507225779 1501 31 7 0.225806451612903 0.00466355762824783
GO:MF GO:0005515 protein binding 0.0442929618367568 14767 44 41 0.931818181818182 0.00277646102796777
GO:MF GO:0008289 lipid binding 0.0485543118446613 776 12 3 0.25 0.0038659793814433
GO:MF GO:0008047 enzyme activator activity 0.0490656099242778 540 17 3 0.176470588235294 0.00555555555555556
HPA HPA:0091072 cerebellum; white matter cells - cytoplasm/membrane[≥Medium] 3.53461743169291e-06 225 22 8 0.363636363636364 0.0355555555555556
HPA HPA:0091071 cerebellum; white matter cells - cytoplasm/membrane[≥Low] 1.16697794429023e-05 292 15 7 0.466666666666667 0.023972602739726
HPA HPA:0091002 cerebellum; molecular layer cells - cytoplasm/membrane[≥Medium] 1.16697794429023e-05 309 15 7 0.466666666666667 0.0226537216828479
HPA HPA:0091001 cerebellum; molecular layer cells - cytoplasm/membrane[≥Low] 1.78892840341255e-05 343 15 7 0.466666666666667 0.0204081632653061
HPA HPA:0091073 cerebellum; white matter cells - cytoplasm/membrane[High] 4.16505417105344e-05 122 15 5 0.333333333333333 0.040983606557377
HPA HPA:0091003 cerebellum; molecular layer cells - cytoplasm/membrane[High] 0.000509234834919537 182 60 8 0.133333333333333 0.043956043956044
HPA HPA:0090902 cerebellum; Bergmann glia - cytoplasm/membrane[≥Medium] 0.000594214277874388 89 60 6 0.1 0.0674157303370786
HPA HPA:0090941 cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] 0.00112603445959901 448 68 12 0.176470588235294 0.0267857142857143
HPA HPA:0090901 cerebellum; Bergmann glia - cytoplasm/membrane[≥Low] 0.00126088596803875 106 60 6 0.1 0.0566037735849057
HPA HPA:0090922 cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] 0.00180974619549254 179 57 7 0.12280701754386 0.0391061452513966
HPA HPA:0090921 cerebellum; GLUC cells - cytoplasm/membrane[≥Low] 0.0030222412443675 197 57 7 0.12280701754386 0.0355329949238579
HPA HPA:0090942 cerebellum; Purkinje cells - cytoplasm/membrane[≥Medium] 0.00352510094053587 368 68 10 0.147058823529412 0.0271739130434783
HPA HPA:0090923 cerebellum; GLUC cells - cytoplasm/membrane[High] 0.00403420387858339 107 49 5 0.102040816326531 0.0467289719626168
HPA HPA:0090903 cerebellum; Bergmann glia - cytoplasm/membrane[High] 0.00444548161997411 48 60 4 0.0666666666666667 0.0833333333333333
HPA HPA:0090943 cerebellum; Purkinje cells - cytoplasm/membrane[High] 0.00567106113656939 191 68 7 0.102941176470588 0.0366492146596859
HPA HPA:0090972 cerebellum; granular cells - cytoplasm/membrane[≥Medium] 0.0064456969764666 231 15 4 0.266666666666667 0.0173160173160173
HPA HPA:0090971 cerebellum; granular cells - cytoplasm/membrane[≥Low] 0.0157876992902655 297 15 4 0.266666666666667 0.0134680134680135
HPA HPA:0090973 cerebellum; granular cells - cytoplasm/membrane[High] 0.0180017213508823 132 15 3 0.2 0.0227272727272727
HPA HPA:0570802 testis; sertoli cells[≥Medium] 0.0233800990214106 1662 68 21 0.308823529411765 0.0126353790613718
HPA HPA:0291161 liver; cholangiocytes[≥Low] 0.0279612096293899 3867 70 38 0.542857142857143 0.00982673907421774
HPA HPA:0290402 liver; hepatocytes[≥Medium] 0.0378323931906173 3640 109 52 0.477064220183486 0.0142857142857143
HPA HPA:0291162 liver; cholangiocytes[≥Medium] 0.039143502261277 1910 67 22 0.328358208955224 0.0115183246073298
HPA HPA:0430000 seminal vesicle 0.039143502261277 6672 119 89 0.747899159663866 0.0133393285371703
HPA HPA:0430051 seminal vesicle; glandular cells[≥Low] 0.039143502261277 6672 119 89 0.747899159663866 0.0133393285371703
HPA HPA:0380513 placenta; decidual cells[High] 0.0430454471812289 1144 103 21 0.203883495145631 0.0183566433566434
HPA HPA:0570801 testis; sertoli cells[≥Low] 0.0484353529026034 2256 88 30 0.340909090909091 0.0132978723404255
HPA HPA:0160253 endometrium 1; cells in endometrial stroma[High] 0.0484353529026034 393 53 7 0.132075471698113 0.0178117048346056
KEGG KEGG:04141 Protein processing in endoplasmic reticulum 2.69790455977731e-09 170 40 12 0.3 0.0705882352941176
KEGG KEGG:03060 Protein export 6.41580949895939e-06 23 83 6 0.072289156626506 0.260869565217391
KEGG KEGG:04918 Thyroid hormone synthesis 0.000296178146539277 75 29 5 0.172413793103448 0.0666666666666667
KEGG KEGG:04964 Proximal tubule bicarbonate reclamation 0.000399806748706406 23 16 3 0.1875 0.130434782608696
KEGG KEGG:04960 Aldosterone-regulated sodium reabsorption 0.00114958540231998 37 16 3 0.1875 0.0810810810810811
KEGG KEGG:04142 Lysosome 0.00114958540231998 128 60 7 0.116666666666667 0.0546875
KEGG KEGG:04973 Carbohydrate digestion and absorption 0.00203137091197763 47 16 3 0.1875 0.0638297872340425
KEGG KEGG:04612 Antigen processing and presentation 0.00226592130948015 69 31 4 0.129032258064516 0.0579710144927536
KEGG KEGG:04961 Endocrine and other factor-regulated calcium reabsorption 0.00226592130948015 53 16 3 0.1875 0.0566037735849057
KEGG KEGG:04978 Mineral absorption 0.00280938569693556 59 16 3 0.1875 0.0508474576271186
KEGG KEGG:04971 Gastric acid secretion 0.00540946921467869 76 16 3 0.1875 0.0394736842105263
KEGG KEGG:04911 Insulin secretion 0.00680924640672892 86 16 3 0.1875 0.0348837209302326
KEGG KEGG:04260 Cardiac muscle contraction 0.00680924640672892 87 16 3 0.1875 0.0344827586206897
KEGG KEGG:04970 Salivary secretion 0.00694918148931601 92 16 3 0.1875 0.0326086956521739
KEGG KEGG:04976 Bile secretion 0.00694918148931601 90 16 3 0.1875 0.0333333333333333
KEGG KEGG:04925 Aldosterone synthesis and secretion 0.00783283321000884 98 16 3 0.1875 0.0306122448979592
KEGG KEGG:04972 Pancreatic secretion 0.0080464268401003 102 16 3 0.1875 0.0294117647058824
KEGG KEGG:04974 Protein digestion and absorption 0.0080464268401003 103 16 3 0.1875 0.029126213592233
KEGG KEGG:04919 Thyroid hormone signaling pathway 0.0121429545406543 121 16 3 0.1875 0.0247933884297521
KEGG KEGG:00513 Various types of N-glycan biosynthesis 0.0157701896104837 39 54 3 0.0555555555555556 0.0769230769230769
KEGG KEGG:04261 Adrenergic signaling in cardiomyocytes 0.0193769825354785 150 16 3 0.1875 0.02
KEGG KEGG:04022 cGMP-PKG signaling pathway 0.023653650787065 166 16 3 0.1875 0.0180722891566265
KEGG KEGG:00190 Oxidative phosphorylation 0.0270569812107782 133 21 3 0.142857142857143 0.0225563909774436
KEGG KEGG:04145 Phagosome 0.0331093763245481 147 21 3 0.142857142857143 0.0204081632653061
KEGG KEGG:04024 cAMP signaling pathway 0.0407400818721894 216 16 3 0.1875 0.0138888888888889
MIRNA MIRNA:hsa-miR-16-5p hsa-miR-16-5p 0.0183705938000299 1556 67 20 0.298507462686567 0.012853470437018
REAC REAC:R-HSA-381119 Unfolded Protein Response (UPR) 4.10876667348081e-06 91 99 10 0.101010101010101 0.10989010989011
REAC REAC:R-HSA-381070 IRE1alpha activates chaperones 5.77039767904174e-05 49 99 7 0.0707070707070707 0.142857142857143
REAC REAC:R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 0.000184991683849803 9 29 3 0.103448275862069 0.333333333333333
REAC REAC:R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 0.000271525216343613 11 29 3 0.103448275862069 0.272727272727273
REAC REAC:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.00027542878274994 25 14 3 0.214285714285714 0.12
REAC REAC:R-HSA-381038 XBP1(S) activates chaperone genes 0.00027542878274994 47 99 6 0.0606060606060606 0.127659574468085
REAC REAC:R-HSA-983712 Ion channel transport 0.00105269944968442 182 21 5 0.238095238095238 0.0274725274725275
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.00113471731652143 113 83 7 0.0843373493975904 0.0619469026548673
REAC REAC:R-HSA-3371453 Regulation of HSF1-mediated heat shock response 0.0014705441656803 67 31 4 0.129032258064516 0.0597014925373134
REAC REAC:R-HSA-5578775 Ion homeostasis 0.00213319544097978 54 16 3 0.1875 0.0555555555555556
REAC REAC:R-HSA-936837 Ion transport by P-type ATPases 0.00213319544097978 55 16 3 0.1875 0.0545454545454545
REAC REAC:R-HSA-210991 Basigin interactions 0.00279416215483669 25 39 3 0.0769230769230769 0.12
REAC REAC:R-HSA-3371556 Cellular response to heat stress 0.00292782354691319 87 31 4 0.129032258064516 0.0459770114942529
REAC REAC:R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 0.00302546443833438 13 83 3 0.036144578313253 0.230769230769231
REAC REAC:R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 0.00740300474200197 18 83 3 0.036144578313253 0.166666666666667
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.00740300474200197 474 40 8 0.2 0.0168776371308017
REAC REAC:R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 0.00945007532027535 20 83 3 0.036144578313253 0.15
REAC REAC:R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 0.00945007532027535 16 106 3 0.0283018867924528 0.1875
REAC REAC:R-HSA-400508 Incretin synthesis, secretion, and inactivation 0.013274691048919 23 83 3 0.036144578313253 0.130434782608696
REAC REAC:R-HSA-3781865 Diseases of glycosylation 0.014157123030136 140 115 7 0.0608695652173913 0.05
REAC REAC:R-HSA-114608 Platelet degranulation 0.0160459609488139 125 67 5 0.0746268656716418 0.04
REAC REAC:R-HSA-5576891 Cardiac conduction 0.0160459609488139 137 16 3 0.1875 0.0218978102189781
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.0176275008438823 130 67 5 0.0746268656716418 0.0384615384615385
REAC REAC:R-HSA-168249 Innate Immune System 0.0196614172987466 1073 40 11 0.275 0.0102516309412861
REAC REAC:R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.022945819635875 95 29 3 0.103448275862069 0.0315789473684211
REAC REAC:R-HSA-8957275 Post-translational protein phosphorylation 0.0245585585523141 107 135 6 0.0444444444444444 0.0560747663551402
REAC REAC:R-HSA-397014 Muscle contraction 0.0300341669704012 205 16 3 0.1875 0.0146341463414634
REAC REAC:R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.0436174272518544 124 135 6 0.0444444444444444 0.0483870967741935
REAC REAC:R-HSA-2980736 Peptide hormone metabolism 0.0437846144675639 86 86 4 0.0465116279069767 0.0465116279069767
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 8.68281019633931e-07 14997 142 136 0.957746478873239 0.00906848036273921
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 6.75903178470106e-05 13270 142 124 0.873239436619718 0.00934438583270535
TF TF:M03988 Factor: FLI1; motif: ACCGGAARTN 6.75903178470106e-05 8318 121 81 0.669421487603306 0.0097379177686944
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 8.38435401492635e-05 14575 137 126 0.91970802919708 0.00864493996569468
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 8.38435401492635e-05 12351 138 115 0.833333333333333 0.00931098696461825
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 8.38435401492635e-05 10253 136 101 0.742647058823529 0.00985077538281479
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.000110527902713082 11232 141 110 0.780141843971631 0.00979344729344729
TF TF:M11404 Factor: Fli-1; motif: NACCGGAARTN 0.000218014441461354 8743 122 82 0.672131147540984 0.00937893171680201
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.000218014441461354 15260 123 116 0.943089430894309 0.00760157273918742
TF TF:M03975 Factor: ERG; motif: ACCGGAARTN 0.000272335182816639 10002 122 89 0.729508196721312 0.00889822035592881
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.000300573384631194 13190 138 118 0.855072463768116 0.0089461713419257
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.000300573384631194 13929 137 121 0.883211678832117 0.00868691219757341
TF TF:M08207_1 Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 0.000300573384631194 15466 142 133 0.936619718309859 0.0085995085995086
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.000300573384631194 14873 142 130 0.915492957746479 0.0087406710145902
TF TF:M09905 Factor: SAP-1; motif: NNCCGGAAGTGN 0.000312218555165597 8273 120 77 0.641666666666667 0.00930738547080865
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.000535793334769101 15268 123 115 0.934959349593496 0.00753209326696358
TF TF:M02066_1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 0.000535793334769101 2283 120 33 0.275 0.0144546649145861
TF TF:M11601 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.000566268841540362 14823 142 129 0.908450704225352 0.00870269176280105
TF TF:M09892 Factor: E2F-1; motif: NNNNGGCGGGAARN 0.000566268841540362 13528 137 118 0.861313868613139 0.00872264931992904
TF TF:M02064 Factor: c-ets-2; motif: ACCGGAWRTN 0.000617069719661379 10939 103 80 0.776699029126214 0.00731328274979431
TF TF:M11603 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.000617069719661379 16361 123 119 0.967479674796748 0.00727339404681865
TF TF:M08224_1 Factor: Elk-1:Pax-1; motif: ACCGGAACTACGCWTSANTG; match class: 1 0.000617069719661379 2748 117 36 0.307692307692308 0.0131004366812227
TF TF:M02053 Factor: ELF1; motif: NCCGGAARTN 0.000617069719661379 6033 69 40 0.579710144927536 0.00663020056356705
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.000655079065593411 16194 115 111 0.965217391304348 0.00685439051500556
TF TF:M00695 Factor: ETF; motif: GVGGMGG 0.000655079065593411 10430 137 99 0.722627737226277 0.00949185043144775
TF TF:M00333_1 Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 0.000655079065593411 12401 141 114 0.808510638297872 0.00919280703169099
TF TF:M11018_1 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 0.000655079065593411 15920 142 134 0.943661971830986 0.00841708542713568
TF TF:M03925 Factor: YY2; motif: NCCGCCATNTY 0.000688942337953123 4641 58 30 0.517241379310345 0.00646412411118293
TF TF:M07250 Factor: E2F-1; motif: NNNSSCGCSAANN 0.000778930136945264 10703 138 101 0.731884057971015 0.00943660655890872
TF TF:M08525 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM 0.000778930136945264 17065 123 121 0.983739837398374 0.00709053618517433
TF TF:M04710 Factor: CHD2; motif: TCTCGCGAG 0.000845180420183388 14109 118 105 0.889830508474576 0.00744205826068467
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.000848851191204734 13022 138 115 0.833333333333333 0.00883120872369836
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.000883741741128134 16228 123 118 0.959349593495935 0.00727138279516884
TF TF:M02065 Factor: ER81; motif: RCCGGAARYN 0.000909348144926464 12550 142 115 0.809859154929577 0.00916334661354582
TF TF:M11400 Factor: Fli-1; motif: NACCGGAARTN 0.000909348144926464 9946 122 86 0.704918032786885 0.00864669213754273
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.000909348144926464 13184 137 115 0.839416058394161 0.00872269417475728
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.000956980520527854 8322 120 75 0.625 0.00901225666906993
TF TF:M02059 Factor: ELK-1; motif: ACCGGAAGTN 0.000956980520527854 9423 138 92 0.666666666666667 0.00976334500689801
TF TF:M02074 Factor: GABPalpha; motif: RCCGGAWRYN 0.000976589225495539 4607 89 40 0.449438202247191 0.00868243976557413
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.00119289806700153 10765 33 30 0.909090909090909 0.00278680910357641
TF TF:M02066 Factor: PEA3; motif: RCCGGAAGYN 0.00119918384686315 7045 121 67 0.553719008264463 0.00951029098651526
TF TF:M11460 Factor: nerf; motif: NANSCGGAAGTN 0.00119918384686315 736 29 8 0.275862068965517 0.0108695652173913
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.00119945669760544 6749 121 65 0.537190082644628 0.00963105645280782
TF TF:M02056 Factor: ELF4; motif: NCCGGAARTN 0.00121549187512239 5332 64 34 0.53125 0.00637659414853713
TF TF:M00333 Factor: ZF5; motif: NRNGNGCGCGCWN 0.00121549187512239 15072 141 128 0.907801418439716 0.00849256900212314
TF TF:M01299 Factor: MECP2; motif: CCGGNNTTWA 0.00121549187512239 5228 114 52 0.456140350877193 0.00994644223412395
TF TF:M00986 Factor: Churchill; motif: CGGGNN 0.00128059182835281 14197 65 61 0.938461538461538 0.00429668239768965
TF TF:M00425 Factor: E2F; motif: TTTCGCGC 0.00128059182835281 11043 138 102 0.739130434782609 0.00923662048356425
TF TF:M08205 Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT 0.00128059182835281 14429 138 122 0.884057971014493 0.00845519440016633
TF TF:M07206_1 Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 0.00136792038814048 10849 137 100 0.72992700729927 0.00921743939533597
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.00166576373842881 10230 126 89 0.706349206349206 0.00869990224828934
TF TF:M04823 Factor: E2F-4; motif: NNTTCCCGCCNN 0.00181795262541418 12747 123 101 0.821138211382114 0.00792343296461913
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.00181795262541418 14106 142 123 0.866197183098592 0.00871969374734156
TF TF:M03977 Factor: ETS1; motif: ACCGGAARYN 0.00182704945567363 10512 122 88 0.721311475409836 0.00837138508371385
TF TF:M08526 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN 0.00186159083551949 16867 142 137 0.964788732394366 0.00812236912313986
TF TF:M01240_1 Factor: BEN; motif: CAGCGRNV; match class: 1 0.00186159083551949 13227 137 114 0.832116788321168 0.00861873440689499
TF TF:M11392 Factor: Erg; motif: NACCGGAARYN 0.00186159083551949 8690 122 77 0.631147540983607 0.00886075949367089
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.00186159083551949 14593 106 96 0.905660377358491 0.00657849653943672
TF TF:M11012 Factor: islet1; motif: SCAMTTAN 0.00186159083551949 6170 108 55 0.509259259259259 0.00891410048622366
TF TF:M02052_1 Factor: EHF; motif: CSCGGAARTN; match class: 1 0.00198362613226817 4056 114 43 0.37719298245614 0.0106015779092702
TF TF:M11434 Factor: Elk-1; motif: NRSCGGAAGNN 0.00201610282230616 8219 138 82 0.594202898550725 0.00997688283246137
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.00224937558115113 8947 127 81 0.637795275590551 0.00905331395998659
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.00233728364700731 11728 142 108 0.76056338028169 0.0092087312414734
TF TF:M01240 Factor: BEN; motif: CAGCGRNV 0.00270166745896753 16498 142 135 0.950704225352113 0.00818281003758031
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.00270166745896753 10116 122 85 0.69672131147541 0.00840253064452353
TF TF:M11455 Factor: ELFR; motif: NANSCGGAAGTN 0.00276282630029082 631 29 7 0.241379310344828 0.0110935023771791
TF TF:M08205_1 Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 0.00293004544815557 10438 137 96 0.700729927007299 0.00919716420770262
TF TF:M01752 Factor: ERG; motif: ACCGGAART 0.00298989371279616 9474 122 81 0.663934426229508 0.00854971500949968
TF TF:M02071_1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 0.00307353216689955 4465 120 47 0.391666666666667 0.0105263157894737
TF TF:M08913_1 Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 0.00307353216689955 3055 92 30 0.326086956521739 0.00981996726677578
TF TF:M02067 Factor: ER71; motif: ACCGGAARYN 0.00307353216689955 5930 114 55 0.482456140350877 0.00927487352445194
TF TF:M02062 Factor: Erg; motif: ACCGGAAGTN 0.00333318965072968 8056 126 74 0.587301587301587 0.00918570009930487
TF TF:M03924_1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 0.00359112030703616 3700 93 34 0.365591397849462 0.00918918918918919
TF TF:M10436 Factor: YY1; motif: CAANATGGCGGC 0.00361052799257323 8220 48 34 0.708333333333333 0.00413625304136253
TF TF:M11541_1 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 0.00377496120656056 5493 137 60 0.437956204379562 0.0109229929000546
TF TF:M11541 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN 0.00377496120656056 5751 137 62 0.452554744525547 0.0107807337854286
TF TF:M00740 Factor: Rb:E2F-1:DP-1; motif: TTTSGCGC 0.00377496120656056 10427 138 96 0.695652173913043 0.00920686678814616
TF TF:M04710_1 Factor: CHD2; motif: TCTCGCGAG; match class: 1 0.00377496120656056 11477 98 76 0.775510204081633 0.00662193953123639
TF TF:M07084 Factor: E2F-4; motif: NGGCGGGAARN 0.00384798581081294 10834 137 98 0.715328467153285 0.00904559719401883
TF TF:M04106 Factor: RUNX2; motif: NRACCGCAAACCGCAN 0.00394634464777473 13833 129 110 0.852713178294574 0.00795199884334562
TF TF:M08207 Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT 0.00407854580308879 17055 102 100 0.980392156862745 0.0058633831720903
TF TF:M00025 Factor: Elk-1; motif: NNNNCCGGAARTNN 0.00421830443427298 10262 122 85 0.69672131147541 0.00828298577275385
TF TF:M11424_1 Factor: Erm; motif: NNSCGGAWGYN; match class: 1 0.00422558081379522 2835 120 34 0.283333333333333 0.0119929453262787
TF TF:M03811 Factor: AP-2gamma; motif: GCCYNCRGSN 0.00425581246501741 8852 110 70 0.636363636363636 0.0079078174423859
TF TF:M03862 Factor: YB-1; motif: NNNNCCAATNN 0.00425581246501741 9198 130 83 0.638461538461538 0.00902370080452272
TF TF:M11435_1 Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 0.0042728933642479 5745 138 62 0.449275362318841 0.0107919930374238
TF TF:M11447_1 Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 0.00462488476113766 2593 80 24 0.3 0.00925568839182414
TF TF:M11654 Factor: HSF1; motif: RGAANRTTCYRGAAN 0.00526295200255454 1353 48 12 0.25 0.00886917960088692
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.00586366684115107 10281 126 87 0.69047619047619 0.00846221184709659
TF TF:M04691_1 Factor: Kaiso; motif: TCTCGCGAG; match class: 1 0.00600580268685074 10488 34 29 0.852941176470588 0.00276506483600305
TF TF:M09950 Factor: HSF1; motif: NRGAANNTTCYRGAA 0.00600580268685074 2501 74 22 0.297297297297297 0.00879648140743703
TF TF:M01770 Factor: XBP-1; motif: WNNGMCACGTC 0.00604425861486225 11003 135 97 0.718518518518519 0.00881577751522312
TF TF:M02069 Factor: Erm; motif: ACCGGAAGTN 0.00621389705705682 6892 126 65 0.515873015873016 0.00943122460824144
TF TF:M04714_1 Factor: Elf-1; motif: ACTTCCGGG; match class: 1 0.00626201065992168 2659 120 32 0.266666666666667 0.0120345994734863
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.00683047912846774 11116 142 102 0.71830985915493 0.00917596257646635
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.00699956559812693 14473 142 123 0.866197183098592 0.0084985835694051
TF TF:M11454 Factor: ELFR; motif: NANGMGGAAGTN 0.007511094701553 1072 29 8 0.275862068965517 0.00746268656716418
TF TF:M11247 Factor: Luman; motif: YGCCACGTCAYC 0.007511094701553 174 86 6 0.0697674418604651 0.0344827586206897
TF TF:M11396_1 Factor: Erg; motif: NACCGGAARTN; match class: 1 0.007511094701553 4963 120 49 0.408333333333333 0.00987306064880113
TF TF:M11655 Factor: HSF1; motif: NGAANGTTCKRGAAN 0.00759239369405519 1207 48 11 0.229166666666667 0.00911350455675228
TF TF:M11018 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN 0.00759239369405519 16955 142 136 0.957746478873239 0.00802123267472722
TF TF:M03988_1 Factor: FLI1; motif: ACCGGAARTN; match class: 1 0.00759239369405519 2950 120 34 0.283333333333333 0.0115254237288136
TF TF:M11457 Factor: nerf; motif: NANGCGGAAGTR 0.00763101248659556 1082 29 8 0.275862068965517 0.00739371534195933
TF TF:M10849 Factor: Cdx-2; motif: NRTCGTAANNNN 0.00771245067598655 11163 142 102 0.71830985915493 0.00913732867508734
TF TF:M11535 Factor: E2F-4; motif: TTTTGGCGCCAWWN 0.00789502676663089 10884 35 30 0.857142857142857 0.00275633958103638
TF TF:M03982 Factor: ETV4; motif: ACCGGAAGTN 0.00796579052996145 6826 126 64 0.507936507936508 0.00937591561675945
TF TF:M08676_1 Factor: C/EBPgamma:Elf-1; motif: TKRCGHAATWSCGGAAGT; match class: 1 0.00801970923024061 2364 6 5 0.833333333333333 0.00211505922165821
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.00819976037369106 8495 122 73 0.598360655737705 0.00859329017068864
TF TF:M02059_1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 0.00841577729281974 3759 120 40 0.333333333333333 0.0106411279595637
TF TF:M09837 Factor: ZNF449; motif: NNNAGCCCARCC 0.00860454804400389 4264 54 24 0.444444444444444 0.00562851782363977
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.00860454804400389 10419 126 87 0.69047619047619 0.0083501295709761
TF TF:M08020 Factor: YY2; motif: NNCCGCCATTW 0.00877263215837393 1331 45 11 0.244444444444444 0.00826446280991736
TF TF:M09905_1 Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 0.00880326184891774 2989 92 28 0.304347826086957 0.00936768149882904
TF TF:M02073 Factor: Fli-1; motif: ACCGGAAGYN 0.00884359633412871 5839 121 55 0.454545454545455 0.00941942113375578
TF TF:M03924 Factor: YY1; motif: NNCGCCATTNN 0.00884359633412871 10084 133 89 0.669172932330827 0.00882586275287584
TF TF:M11430_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.00929114955114366 4902 92 39 0.423913043478261 0.00795593635250918
TF TF:M00738 Factor: E2F-4:DP-1; motif: TTTSGCGC 0.00929114955114366 9812 138 90 0.652173913043478 0.00917244190786792
TF TF:M11601_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.0095204621066609 11053 42 35 0.833333333333333 0.00316656111462951
TF TF:M01770_1 Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 0.0095204621066609 4554 135 50 0.37037037037037 0.0109793588054458
TF TF:M08213 Factor: Elk-1:TBR2; motif: TNRCACCGGAAGN 0.0107741363082622 6273 140 65 0.464285714285714 0.0103618683245656
TF TF:M02054 Factor: ELF2; motif: CCCGGAARYN 0.0107741363082622 3066 114 33 0.289473684210526 0.0107632093933464
TF TF:M08423 Factor: TEF-3:ER81; motif: ACCGGAAATRCC 0.0108191330959347 3845 89 32 0.359550561797753 0.00832249674902471
TF TF:M11430 Factor: PEA3; motif: NACCGGAAGTN 0.0108428613750132 10865 140 98 0.7 0.00901978831109066
TF TF:M03925_1 Factor: YY2; motif: NCCGCCATNTY; match class: 1 0.0111662362574345 765 66 10 0.151515151515152 0.0130718954248366
TF TF:M09608 Factor: Erg; motif: NNACCGGAARTSN 0.0111805800321391 8152 138 78 0.565217391304348 0.00956820412168793
TF TF:M11427 Factor: PEA3; motif: NACCGGAAGTN 0.0111805800321391 10585 122 85 0.69672131147541 0.00803023145961266
TF TF:M07300 Factor: NF-1C; motif: TTGGCNN 0.0113500586424778 6211 93 46 0.494623655913978 0.00740621478022863
TF TF:M11427_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.011363616428427 4606 92 37 0.402173913043478 0.00803300043421624
TF TF:M09832 Factor: RFX1; motif: NGTTGCCATGG 0.011363616428427 2370 37 13 0.351351351351351 0.00548523206751055
TF TF:M07100_1 Factor: HSF1; motif: NTTCTRGAANNTTCY; match class: 1 0.011363616428427 514 116 11 0.0948275862068965 0.0214007782101167
TF TF:M08319 Factor: GCMa:HOXA13; motif: RTGCGGGTAATAAA 0.0113958224137159 455 6 3 0.5 0.00659340659340659
TF TF:M00428_1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 0.0113958224137159 3615 127 40 0.31496062992126 0.0110650069156293
TF TF:M00327_1 Factor: Pax-3; motif: NNNNNNCGTCACGSTYNNNNN; match class: 1 0.0113958224137159 6888 127 64 0.503937007874016 0.00929152148664344
TF TF:M11656 Factor: HSF1; motif: RGAANRTTCYRGAAN 0.0115334305728061 2033 48 14 0.291666666666667 0.00688637481554353
TF TF:M07459 Factor: HSF1; motif: GAANNTTCTNGN 0.0116266358113568 3422 52 20 0.384615384615385 0.00584453535943892
TF TF:M01045_1 Factor: AP-2alphaA; motif: ANNGCCTNAGGSNNT; match class: 1 0.0116266358113568 2116 7 5 0.714285714285714 0.00236294896030246
TF TF:M11481 Factor: AP-2gamma; motif: NSCCYNRGGSN 0.0116266358113568 4868 119 47 0.394957983193277 0.00965488907148726
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.0117356253933526 13173 123 100 0.813008130081301 0.00759128520458514
TF TF:M03978 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN 0.0122015436658084 12082 142 107 0.753521126760563 0.00885614964409866
TF TF:M11393_1 Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 0.0123123282577729 13665 47 43 0.914893617021277 0.00314672521039151
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.0123123282577729 10640 122 85 0.69672131147541 0.00798872180451128
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0123123282577729 10233 126 85 0.674603174603175 0.00830645949379459
TF TF:M00243 Factor: Egr-1; motif: WTGCGTGGGCGK 0.0123123282577729 5356 136 56 0.411764705882353 0.0104555638536221
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.0123123282577729 5133 120 49 0.408333333333333 0.00954607442041691
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.0123123282577729 16103 142 131 0.922535211267606 0.00813513009998137
TF TF:M08313_1 Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 0.0124333893443098 9721 102 68 0.666666666666667 0.00699516510647053
TF TF:M04379 Factor: ISL2; motif: GCAMTTAR 0.0124333893443098 4391 142 50 0.352112676056338 0.0113869278068777
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.0126479071427277 4841 114 45 0.394736842105263 0.00929560008262756
TF TF:M11662 Factor: HSF2; motif: RGAANGTTCYRGAAN 0.0126627727905296 272 66 6 0.0909090909090909 0.0220588235294118
TF TF:M02063_1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 0.0126627727905296 2396 47 15 0.319148936170213 0.00626043405676127
TF TF:M04748_1 Factor: GABP-alpha; motif: AACCGGAAR; match class: 1 0.0127024513369978 10368 60 45 0.75 0.00434027777777778
TF TF:M11529 Factor: E2F-2; motif: GCGCGCGCNCS 0.0127024513369978 16263 123 115 0.934959349593496 0.00707126606407182
TF TF:M12231_1 Factor: LRF; motif: NCGACCACCGN; match class: 1 0.0129822672990828 5126 136 54 0.397058823529412 0.0105345298478346
TF TF:M11392_1 Factor: Erg; motif: NACCGGAARYN; match class: 1 0.0132632528546495 3233 120 35 0.291666666666667 0.0108258583359109
TF TF:M07250_1 Factor: E2F-1; motif: NNNSSCGCSAANN; match class: 1 0.0132721290550746 5515 116 50 0.431034482758621 0.00906618313689937
TF TF:M05432 Factor: ZSCAN18; motif: TRRCGRCGNMCC 0.0132721290550746 4117 118 41 0.347457627118644 0.00995870779693952
TF TF:M05438 Factor: Osx; motif: WGGGCGGGTS 0.0132721290550746 181 141 7 0.049645390070922 0.0386740331491713
TF TF:M06069 Factor: ZNF253; motif: KKGCARMMGM 0.0132721290550746 1560 134 23 0.171641791044776 0.0147435897435897
TF TF:M08231 Factor: Elk-1:T-bet; motif: TCACACCGGAAGNN 0.0133833846882365 6635 140 67 0.478571428571429 0.0100979653353429
TF TF:M04953 Factor: Sp1; motif: GGNDGGRGGCGGGG 0.0135188747254675 8688 71 46 0.647887323943662 0.00529465930018416
TF TF:M01199 Factor: RNF96; motif: BCCCGCRGCC 0.0136391649505571 8473 43 30 0.697674418604651 0.00354065856249262
TF TF:M03990 Factor: GABPA; motif: ACCGGAAGTN 0.0136500130157434 5258 89 39 0.438202247191011 0.00741726892354507
TF TF:M09632 Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN 0.0141238006496477 3001 14 8 0.571428571428571 0.00266577807397534
TF TF:M11481_1 Factor: AP-2gamma; motif: NSCCYNRGGSN; match class: 1 0.0141741501851722 4662 119 45 0.378151260504202 0.00965250965250965
TF TF:M11530_1 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 0.0141741501851722 13449 123 101 0.821138211382114 0.00750985203360845
TF TF:M08341 Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN 0.0143342965969312 6145 93 45 0.483870967741935 0.00732302685109845
TF TF:M10578_1 Factor: Barhl-1; motif: NTAAACGN; match class: 1 0.0146058731059284 1391 63 13 0.206349206349206 0.00934579439252336
TF TF:M01876 Factor: GABP-beta; motif: ASMGGAAGKGN 0.0149673177451424 2138 139 29 0.20863309352518 0.0135640785781104
TF TF:M03971 Factor: ELK1; motif: NACTTCCGSCGGAAGYN 0.0150758398887439 11293 88 66 0.75 0.00584432834499247
TF TF:M00025_1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 0.0150758398887439 4639 120 45 0.375 0.00970036645828842
TF TF:M11434_1 Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 0.0157600994156391 2935 80 24 0.3 0.00817717206132879
TF TF:M04099_1 Factor: RFX4; motif: NGTWRCCATGGYWACN; match class: 1 0.016479095563944 210 34 4 0.117647058823529 0.019047619047619
TF TF:M11479_1 Factor: AP-2alpha; motif: NGCCTNAGGCN; match class: 1 0.016479095563944 3649 93 31 0.333333333333333 0.0084954782132091
TF TF:M11419 Factor: ER81; motif: NNCCGGAWGYN 0.016702907552973 5699 114 50 0.43859649122807 0.00877346902965432
TF TF:M11424 Factor: Erm; motif: NNSCGGAWGYN 0.0170654329519321 8149 122 69 0.565573770491803 0.00846729660080991
TF TF:M01752_1 Factor: ERG; motif: ACCGGAART; match class: 1 0.0171591163601307 3705 92 31 0.33695652173913 0.00836707152496626
TF TF:M11404_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0172463041754399 3171 120 34 0.283333333333333 0.010722169662567
TF TF:M08759_1 Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 0.0175000256388657 2915 120 32 0.266666666666667 0.0109777015437393
TF TF:M11205 Factor: TCFL4; motif: NNCACGTGNYN 0.0175000256388657 87 83 4 0.0481927710843374 0.0459770114942529
TF TF:M11253 Factor: AIBZIP; motif: YGCCACGTCACC 0.0175000256388657 229 86 6 0.0697674418604651 0.0262008733624454
TF TF:M11256 Factor: AIBZIP; motif: NGCCACGTCAYN 0.0179874348056536 1323 68 13 0.191176470588235 0.00982615268329554
TF TF:M09868 Factor: ATF-3; motif: GGTSACGTGAN 0.0180375478388543 6391 69 36 0.521739130434783 0.0056329212955719
TF TF:M00069 Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW 0.0183917952821316 8347 90 54 0.6 0.00646939020007188
TF TF:M09605 Factor: Elf-1; motif: NAANCMGGAAGTGN 0.0183917952821316 5778 86 40 0.465116279069767 0.00692281066112842
TF TF:M08320 Factor: GCMa:HOXB13; motif: RTGCGGGTMATAAAN 0.0186615897070751 837 10 4 0.4 0.004778972520908
TF TF:M00915 Factor: AP-2; motif: SNNNCCNCAGGCN 0.0186615897070751 9612 94 62 0.659574468085106 0.00645027049521432
TF TF:M08243 Factor: ERF:Max; motif: ACCGGAAACACGTGN 0.0186615897070751 1398 65 13 0.2 0.00929899856938484
TF TF:M03862_1 Factor: YB-1; motif: NNNNCCAATNN; match class: 1 0.0186800790129316 3120 104 30 0.288461538461538 0.00961538461538462
TF TF:M07043 Factor: HIF-1alpha; motif: NNACGTGNN 0.0189035057321297 1439 34 9 0.264705882352941 0.00625434329395414
TF TF:M07356 Factor: HIF2A; motif: ACGTGNNN 0.0190503310668602 1852 22 8 0.363636363636364 0.00431965442764579
TF TF:M10514_1 Factor: GLI4; motif: RGGCCTTGAATGCCANGCYMA; match class: 1 0.0196000187195851 5935 11 9 0.818181818181818 0.00151642796967144
TF TF:M07380_1 Factor: E2F-4; motif: NTTTCSCGCC; match class: 1 0.020157435153819 7965 138 75 0.543478260869565 0.00941619585687382
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.020157435153819 10494 16 15 0.9375 0.00142938822184105
TF TF:M00516 Factor: E2F-1; motif: TTTSGCGCGMNR 0.020157435153819 6904 116 58 0.5 0.00840092699884125
TF TF:M04691 Factor: Kaiso; motif: TCTCGCGAG 0.020157435153819 15113 60 56 0.933333333333333 0.00370541917554423
TF TF:M07338 Factor: Sox-10; motif: ACAAWGNN 0.0205086816465927 1695 3 3 1 0.00176991150442478
TF TF:M00695_1 Factor: ETF; motif: GVGGMGG; match class: 1 0.0208363427702665 7032 126 63 0.5 0.00895904436860068
TF TF:M09611 Factor: ER81; motif: NNNGRCMGGAAGYRNNNNNNNS 0.0211323571339229 2666 138 33 0.239130434782609 0.0123780945236309
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0212767605506143 13611 72 62 0.861111111111111 0.00455513922562633
TF TF:M04950 Factor: Egr-1; motif: NGCGTGCGY 0.0218563632281529 10935 123 86 0.699186991869919 0.00786465477823503
TF TF:M04714 Factor: Elf-1; motif: ACTTCCGGG 0.0220886063189628 7798 126 68 0.53968253968254 0.00872018466273403
TF TF:M04950_1 Factor: Egr-1; motif: NGCGTGCGY; match class: 1 0.0223061445454788 5551 136 56 0.411764705882353 0.0100882723833544
TF TF:M03970 Factor: ELK1; motif: ACCGGAAGTN 0.0224129595866004 4782 84 34 0.404761904761905 0.00710999581764952
TF TF:M11389 Factor: elf5; motif: GAMCCGGAAGTN 0.0226240591483429 1308 31 8 0.258064516129032 0.00611620795107034
TF TF:M11015 Factor: ISL2; motif: SCACTTAN 0.0227557673902621 4207 142 47 0.330985915492958 0.0111718564297599
TF TF:M11436 Factor: SAP-1; motif: NRNCGGAWRYN 0.0227557673902621 1431 82 15 0.182926829268293 0.010482180293501
TF TF:M11400_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0228718806618527 4201 120 41 0.341666666666667 0.00975958105213045
TF TF:M10893 Factor: PMX2B; motif: NCAATTAN 0.023249260443271 2080 41 12 0.292682926829268 0.00576923076923077
TF TF:M10894 Factor: PMX2B; motif: NYAATTAS 0.023249260443271 2080 41 12 0.292682926829268 0.00576923076923077
TF TF:M10884 Factor: PRX-2; motif: NCAATTAN 0.023249260443271 2080 41 12 0.292682926829268 0.00576923076923077
TF TF:M11428 Factor: PEA3; motif: NACCGGAAGTN 0.023249260443271 7186 122 62 0.508196721311475 0.00862788755914278
TF TF:M04106_1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 0.023249260443271 8372 137 77 0.562043795620438 0.00919732441471572
TF TF:M09901 Factor: nerf; motif: NNNCCGGAAGTGN 0.023249260443271 5352 120 49 0.408333333333333 0.00915545590433483
TF TF:M07415 Factor: Elf-1; motif: AWCCCGGAAGTN 0.023249260443271 7978 126 69 0.547619047619048 0.00864878415643018
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0232976186109 16384 137 127 0.927007299270073 0.00775146484375
TF TF:M08982 Factor: YY1; motif: NAANATGGCGNNN 0.0233827260575007 7125 7 7 1 0.000982456140350877
TF TF:M11393 Factor: Erg; motif: NACCGGATATCCGGTN 0.02354875412961 14105 47 43 0.914893617021277 0.00304856433888692
TF TF:M10635_1 Factor: Nkx2-3; motif: GNCGTTRAG; match class: 1 0.0240523303145084 703 6 3 0.5 0.0042674253200569
TF TF:M00938 Factor: E2F-1; motif: TTGGCGCGRAANNGNM 0.0241166474195924 7334 136 69 0.507352941176471 0.0094082356149441
TF TF:M06246 Factor: ZNF177; motif: NRWTGAAGAGCA 0.0243861886446234 174 125 6 0.048 0.0344827586206897
TF TF:M07100 Factor: HSF1; motif: NTTCTRGAANNTTCY 0.0243861886446234 3350 74 24 0.324324324324324 0.00716417910447761
TF TF:M11447 Factor: Elf-1; motif: NAMCCGGAAGTN 0.0250662931254324 7703 126 67 0.531746031746032 0.00869790990523173
TF TF:M09595 Factor: BCL-11A; motif: NAAAGAGGAAGTGARAN 0.0254097744706056 3696 16 9 0.5625 0.00243506493506494
TF TF:M11432_1 Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 0.0254741009232941 1525 138 22 0.159420289855072 0.0144262295081967
TF TF:M11433 Factor: Elk-1; motif: NRCCGGAAGTN 0.0260011769704301 7679 120 64 0.533333333333333 0.00833441854408126
TF TF:M08226_1 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 0.0260011769704301 5604 139 57 0.410071942446043 0.0101713062098501
TF TF:M10644 Factor: Homeobox; motif: NCAMTTANC 0.0260011769704301 3682 108 34 0.314814814814815 0.00923411189570885
TF TF:M09632_1 Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN; match class: 1 0.0263831073879165 679 23 5 0.217391304347826 0.00736377025036819
TF TF:M10699_1 Factor: HOXB5; motif: NYMATTAN; match class: 1 0.027439089727089 126 119 5 0.0420168067226891 0.0396825396825397
TF TF:M10697_1 Factor: HOXB5; motif: NYMATTAN; match class: 1 0.027439089727089 126 119 5 0.0420168067226891 0.0396825396825397
TF TF:M00539_1 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1 0.0275504479417273 6676 66 35 0.53030303030303 0.00524266027561414
TF TF:M11381_1 Factor: ESE-1; motif: SATKGCGGATGCN; match class: 1 0.0275504479417273 9745 119 76 0.638655462184874 0.00779887121600821
TF TF:M00539 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN 0.0275504479417273 6676 66 35 0.53030303030303 0.00524266027561414
TF TF:M00189 Factor: AP-2; motif: MKCCCSCNGGCG 0.027874937289389 10621 142 95 0.669014084507042 0.00894454382826476
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.0279307925953679 11063 126 88 0.698412698412698 0.00795444273705143
TF TF:M11657 Factor: HSF1; motif: NGAANRTTCKAGAAN 0.0280254319848136 337 68 6 0.0882352941176471 0.0178041543026706
TF TF:M10086 Factor: TAFII250; motif: RARRWGGCGGMGGNGR 0.0280254319848136 9262 47 33 0.702127659574468 0.00356294536817102
TF TF:M02055 Factor: ESE-1; motif: NSMGGAARTN 0.0280254319848136 7559 70 40 0.571428571428571 0.00529170525201746
TF TF:M01214 Factor: ESE-1; motif: NSMGGAARTN 0.0280254319848136 7559 70 40 0.571428571428571 0.00529170525201746
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.0280254319848136 9162 137 82 0.598540145985402 0.00895001091464746
TF TF:M08390_1 Factor: A-Myb:Elf-1; motif: NMCCGGAACCGTTA; match class: 1 0.0280254319848136 4784 118 44 0.372881355932203 0.00919732441471572
TF TF:M03976 Factor: ERG; motif: ACCGGAWATCCGGT 0.0287144952780202 12803 36 32 0.888888888888889 0.00249941419979692
TF TF:M11179 Factor: ASH-2; motif: ACACGACGCN 0.0289106026163373 2162 21 8 0.380952380952381 0.00370027752081406
TF TF:M08616 Factor: A-Myb:Max; motif: YAACSGNNNNNNNNNNCACGTG 0.0292829155935212 395 59 6 0.101694915254237 0.0151898734177215
TF TF:M11027 Factor: Six-1; motif: NCGTATCRNN 0.0298860955727549 3180 66 21 0.318181818181818 0.00660377358490566
TF TF:M08875_1 Factor: E2F; motif: NNTTTCGCGCN; match class: 1 0.0299258578865852 1719 51 12 0.235294117647059 0.00698080279232112
TF TF:M00007 Factor: Elk-1; motif: NAAACMGGAAGTNCVH 0.0299258578865852 5873 93 42 0.451612903225806 0.00715137067938021
TF TF:M02012_1 Factor: HIF-1alpha; motif: NCACGT; match class: 1 0.0299258578865852 1770 122 22 0.180327868852459 0.0124293785310734
TF TF:M09732_1 Factor: RFX3; motif: NYNCCMTGGCAACM; match class: 1 0.0305325483538168 982 34 7 0.205882352941176 0.00712830957230143
TF TF:M03975_1 Factor: ERG; motif: ACCGGAARTN; match class: 1 0.0305419597661337 4024 120 39 0.325 0.00969184890656064
TF TF:M02063 Factor: c-ets-1; motif: ACCGGAWGTN 0.0311930555977294 7600 120 63 0.525 0.00828947368421053
TF TF:M11014 Factor: ISL2; motif: NCAMTTAN 0.0316964414203159 3602 142 41 0.288732394366197 0.0113825652415325
TF TF:M00245 Factor: Egr-3; motif: NTGCGTGGGCGK 0.0316979145209432 7313 122 62 0.508196721311475 0.00847805278271571
TF TF:M02106_1 Factor: NF-YA; motif: CRGCCAATCAGNRN; match class: 1 0.0316979145209432 217 20 3 0.15 0.0138248847926267
TF TF:M00431 Factor: E2F-1; motif: TTTSGCGS 0.0321710557628115 7257 116 59 0.508620689655172 0.00813008130081301
TF TF:M03976_1 Factor: ERG; motif: ACCGGAWATCCGGT; match class: 1 0.0321721535750417 7781 31 21 0.67741935483871 0.00269888189178769
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.0327023365421096 6334 126 57 0.452380952380952 0.00899905273129144
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0327023365421096 9362 126 77 0.611111111111111 0.00822473830378124
TF TF:M11882_1 Factor: pax-6; motif: NYACGCNYSANYGMNCN; match class: 1 0.0327023365421096 11423 142 100 0.704225352112676 0.00875426770550643
TF TF:M09606 Factor: nerf; motif: NRRNSCGGAAGNRNNNN 0.0327023365421096 6249 86 41 0.476744186046512 0.00656104976796287
TF TF:M03805_1 Factor: YB-1; motif: CCAMTCNGMR; match class: 1 0.0327023365421096 3680 33 14 0.424242424242424 0.00380434782608696
TF TF:M11450 Factor: Elf-1; motif: NANSCGGAAGTR 0.0327023365421096 5601 67 31 0.462686567164179 0.00553472594179611
TF TF:M01258 Factor: GABP; motif: CACTTCCGGNNN 0.0333159944698181 2838 120 30 0.25 0.0105708245243129
TF TF:M01078_1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 0.0333159944698181 2448 120 27 0.225 0.0110294117647059
TF TF:M08877 Factor: EGR3; motif: NCMCRCCCACTNMN 0.0333159944698181 6099 45 24 0.533333333333333 0.00393507132316773
TF TF:M01816_1 Factor: ZBP89; motif: YCCYCCCCCM; match class: 1 0.0333159944698181 237 69 5 0.072463768115942 0.0210970464135021
TF TF:M08529 Factor: E2F-3:T-bet; motif: AGGTGTNANGGCGCST 0.0333159944698181 11439 12 12 1 0.001049042748492
TF TF:M01104_1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 0.0333159944698181 5626 43 22 0.511627906976744 0.00391041592605759
TF TF:M09723 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS 0.0339615101508393 10156 72 50 0.694444444444444 0.00492319810949193
TF TF:M09606_1 Factor: nerf; motif: NRRNSCGGAAGNRNNNN; match class: 1 0.0342143213286848 1704 33 9 0.272727272727273 0.00528169014084507
TF TF:M10020_1 Factor: OSR2; motif: NNNNCWGCTNCTGNNG; match class: 1 0.0343043267120489 667 65 8 0.123076923076923 0.0119940029985007
TF TF:M01972 Factor: EGR-1; motif: TGCGTGGGCGK 0.0343043267120489 5360 126 50 0.396825396825397 0.00932835820895522
TF TF:M02053_1 Factor: ELF1; motif: NCCGGAARTN; match class: 1 0.0343219804971722 1559 89 16 0.179775280898876 0.0102629890955741
TF TF:M09760 Factor: DPF2; motif: NYCACYTCCYCNYYCY 0.0350082791611332 8179 45 29 0.644444444444444 0.00354566572930676
TF TF:M11446 Factor: Elf-1; motif: RANSMGGAAGTR 0.0366077825979191 2915 50 16 0.32 0.00548885077186964
TF TF:M11417 Factor: c-Ets-2; motif: NACCGGAAGYRCTTCCGGTN 0.0368144709972291 14334 73 64 0.876712328767123 0.00446490860890191
TF TF:M08954_1 Factor: FXR:RXR-ALPHA; motif: NAGKTCATTGACCYN; match class: 1 0.0368144709972291 2260 52 14 0.269230769230769 0.00619469026548673
TF TF:M11399 Factor: Fli-1; motif: NACCGGAWWTCCGGTY 0.0368144709972291 12977 117 92 0.786324786324786 0.00708946597826925
TF TF:M12341 Factor: BCL-6; motif: NYGCTTTCKAGGAANN 0.0368144709972291 6051 29 17 0.586206896551724 0.00280945298297802
TF TF:M11391 Factor: Erg; motif: NACCGGATATCCGGTN 0.0368339600775563 10082 117 76 0.64957264957265 0.00753818686768498
TF TF:M08295 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM 0.0370288578599719 11711 66 51 0.772727272727273 0.00435488002732474
TF TF:M04147_1 Factor: TFAP2A; motif: NGCCYSAGGCN; match class: 1 0.0374574303572494 1962 47 12 0.25531914893617 0.00611620795107034
TF TF:M00225 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN 0.0374574303572494 3188 7 5 0.714285714285714 0.00156838143036386
TF TF:M09913 Factor: ER81; motif: NNCCGGAAGYG 0.0375107623060428 2871 120 30 0.25 0.0104493207941484
TF TF:M09904 Factor: Elk-1; motif: RCCGGAAGTGN 0.0376974452760609 8164 120 66 0.55 0.00808427241548261
TF TF:M11451_1 Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 0.0376974452760609 2112 33 10 0.303030303030303 0.00473484848484848
TF TF:M09904_1 Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 0.0376974452760609 2743 120 29 0.241666666666667 0.010572366022603
TF TF:M02067_1 Factor: ER71; motif: ACCGGAARYN; match class: 1 0.0377097600692101 1619 120 20 0.166666666666667 0.0123533045089561
TF TF:M07140_1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 0.0377679049593039 189 133 6 0.0451127819548872 0.0317460317460317
TF TF:M09935 Factor: GABP-alpha; motif: NNNRCCGGAAGTGN 0.0379068379636947 4420 84 31 0.369047619047619 0.00701357466063348
TF TF:M12345 Factor: Zbtb37; motif: NYACCGCRNTCACCGCR 0.0382612739819001 5505 69 31 0.449275362318841 0.00563124432334242
TF TF:M11462 Factor: nerf; motif: AAYSCGGAAGTR 0.0382612739819001 449 57 6 0.105263157894737 0.0133630289532294
TF TF:M11382_1 Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 0.0383037723681522 4112 120 39 0.325 0.00948443579766537
TF TF:M07428 Factor: Six-3; motif: NWBTAATNYYWN 0.0383037723681522 3352 33 13 0.393939393939394 0.00387828162291169
TF TF:M11656_1 Factor: HSF1; motif: RGAANRTTCYRGAAN; match class: 1 0.0383037723681522 219 116 6 0.0517241379310345 0.0273972602739726
TF TF:M11227 Factor: ATF-6; motif: TGRTGACGTGGCAN 0.0383037723681522 201 86 5 0.0581395348837209 0.0248756218905473
TF TF:M11017 Factor: DPRX; motif: AGATAATCCN 0.0383037723681522 930 6 3 0.5 0.0032258064516129
TF TF:M12231 Factor: LRF; motif: NCGACCACCGN 0.0383037723681522 11477 136 96 0.705882352941177 0.00836455519735122
TF TF:M11880_1 Factor: pax-6; motif: NYACGCWTSANYGMNCN; match class: 1 0.0383037723681522 7046 142 68 0.47887323943662 0.00965086573942663
TF TF:M01034 Factor: Ebox; motif: NCACSTGNCN 0.0386195554578627 4854 14 9 0.642857142857143 0.00185414091470952
TF TF:M03812 Factor: arnt; motif: CACGYA 0.039674417489173 4330 86 31 0.36046511627907 0.00715935334872979
TF TF:M04228 Factor: XBP1; motif: WNNGMCACGTCATC 0.039674417489173 57 86 3 0.0348837209302326 0.0526315789473684
TF TF:M11452 Factor: Elf-1; motif: NANGCGGAAGTR 0.039674417489173 6276 33 19 0.575757575757576 0.00302740599107712
TF TF:M10112 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR 0.0401458144788711 8711 102 60 0.588235294117647 0.00688784295718058
TF TF:M11425 Factor: PEA3; motif: NACCGGAAGTN 0.0404467117921139 7428 122 62 0.508196721311475 0.00834679590737749
TF TF:M00069_1 Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW; match class: 1 0.040550261630397 2205 60 15 0.25 0.00680272108843537
TF TF:M11074 Factor: DEC1; motif: GTCACGTGAC 0.0407725415376706 4132 120 39 0.325 0.00943852855759923
TF TF:M02052 Factor: EHF; motif: CSCGGAARTN 0.0408370556827293 10107 126 81 0.642857142857143 0.00801424755120214
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.0408370556827293 8227 126 69 0.547619047619048 0.00838701835419959
TF TF:M11172 Factor: HEN2; motif: NGGNCGCAGCTGCGYCCC 0.0408399882545774 64 78 3 0.0384615384615385 0.046875
TF TF:M08341_1 Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN; match class: 1 0.0408399882545774 1317 138 19 0.13768115942029 0.0144267274107821
TF TF:M10514 Factor: GLI4; motif: RGGCCTTGAATGCCANGCYMA 0.0409495298880772 12698 14 14 1 0.00110253583241455
TF TF:M08897 Factor: SMAD; motif: TGTCTGNNN 0.0409495298880772 4543 10 7 0.7 0.00154083204930663
TF TF:M11415 Factor: GABP-alpha; motif: NRCCGGAAGTN 0.0409507196289411 3257 85 25 0.294117647058824 0.00767577525330058
TF TF:M11256_1 Factor: AIBZIP; motif: NGCCACGTCAYN; match class: 1 0.0409582972095509 75 67 3 0.0447761194029851 0.04
TF TF:M09944 Factor: HIF-1alpha; motif: GNACGTGM 0.0409582972095509 5581 29 16 0.551724137931034 0.00286686973660634
TF TF:M11395 Factor: Erg; motif: NACCGGAWWTCCGGTN 0.040983121549835 8715 47 31 0.659574468085106 0.00355708548479633
TF TF:M10590 Factor: BSX; motif: NYRATTAN 0.0410948869688833 2715 45 14 0.311111111111111 0.00515653775322284
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0412774319300506 7728 118 62 0.525423728813559 0.00802277432712215
TF TF:M02077_1 Factor: Spic; motif: NGNGGAASTN; match class: 1 0.0414024438408528 2260 37 11 0.297297297297297 0.00486725663716814
TF TF:M02102 Factor: NRF-1; motif: YGCGCMTGCGC 0.0414024438408528 2020 141 26 0.184397163120567 0.0128712871287129
TF TF:M11658 Factor: HSF4; motif: RGAANNTTCYRGAAN 0.0414024438408528 400 66 6 0.0909090909090909 0.015
TF TF:M11379 Factor: ESE-1; motif: ACCCGGAAGTRNNNNNNNNWWWW 0.0416216834982037 3200 31 12 0.387096774193548 0.00375
TF TF:M00977 Factor: EBF; motif: KTCCCYWGRGA 0.0416216834982037 2283 6 4 0.666666666666667 0.0017520805957074
TF TF:M08213_1 Factor: Elk-1:TBR2; motif: TNRCACCGGAAGN; match class: 1 0.0416350282780181 1417 83 14 0.168674698795181 0.00988002822865208
TF TF:M08800 Factor: ARNT; motif: YRCGTGNN 0.0416350282780181 914 127 14 0.110236220472441 0.0153172866520788
TF TF:M04099 Factor: RFX4; motif: NGTWRCCATGGYWACN 0.0416350282780181 323 34 4 0.117647058823529 0.0123839009287926
TF TF:M08418_1 Factor: TEF-3:Elk-1; motif: RMATWCCGGAWGT; match class: 1 0.0416350282780181 5247 112 44 0.392857142857143 0.00838574423480084
TF TF:M08390 Factor: A-Myb:Elf-1; motif: NMCCGGAACCGTTA 0.0416350282780181 11072 136 93 0.683823529411765 0.00839956647398844
TF TF:M10638 Factor: Nkx2-3; motif: NNCGTTRWS 0.04167711700646 10804 134 90 0.671641791044776 0.00833024805627545
TF TF:M08266_1 Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 0.0420330429744485 8979 117 69 0.58974358974359 0.00768459739391914
TF TF:M07141 Factor: FPM315; motif: GGAGGAGGRRGRGGRGGRRGR 0.044208107124654 2175 14 6 0.428571428571429 0.00275862068965517
TF TF:M02012 Factor: HIF-1alpha; motif: NCACGT 0.0443977015942714 6648 50 27 0.54 0.00406137184115523
TF TF:M00225_1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 0.0443977015942714 1922 7 4 0.571428571428571 0.00208116545265349
TF TF:M11022 Factor: IRX2a; motif: ACRYGNNNNACRYGT 0.0455404518261186 9487 132 80 0.606060606060606 0.00843259196795615
TF TF:M07612 Factor: PSF; motif: KWATCCGN 0.0462477869735075 5581 127 51 0.401574803149606 0.00913814728543272
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0462590654238891 5919 126 53 0.420634920634921 0.00895421523906065
TF TF:M10436_1 Factor: YY1; motif: CAANATGGCGGC; match class: 1 0.0462590654238891 2285 83 19 0.228915662650602 0.00831509846827133
TF TF:M02017_1 Factor: HSF1; motif: GAANNTTCTRGNAN; match class: 1 0.0462590654238891 543 68 7 0.102941176470588 0.0128913443830571
TF TF:M11381 Factor: ESE-1; motif: SATKGCGGATGCN 0.0462590654238891 15720 69 64 0.927536231884058 0.00407124681933842
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 0.0462590654238891 5051 120 45 0.375 0.00890912690556325
TF TF:M10726_1 Factor: HOXB8; motif: NYMATTAN; match class: 1 0.0468352454599982 229 119 6 0.0504201680672269 0.0262008733624454
TF TF:M11490_1 Factor: LBP-1; motif: NRCCGGTNNNNACCGGYN; match class: 1 0.0468670437373921 5988 122 52 0.426229508196721 0.00868403473613895
TF TF:M08306 Factor: GCMa:Elf-1; motif: NNCGGAARTGCKGGT 0.0470101882659362 2776 19 8 0.421052631578947 0.00288184438040346
TF TF:M06288 Factor: ZNF829; motif: NTGKACAYCAGM 0.0471500674348602 161 71 4 0.0563380281690141 0.0248447204968944
TF TF:M11448_1 Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 0.0472630112169827 2324 138 28 0.202898550724638 0.0120481927710843
TF TF:M08225_1 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 0.0472630112169827 7993 139 73 0.525179856115108 0.00913299136744652
TF TF:M11399_1 Factor: Fli-1; motif: NACCGGAWWTCCGGTY; match class: 1 0.0473271940357469 11513 47 37 0.787234042553192 0.00321375836011465
TF TF:M07259 Factor: HSF1; motif: TCYAGAANNTTC 0.0475996324426676 4742 52 22 0.423076923076923 0.00463939266132434
TF TF:M11276 Factor: XBP-1; motif: NNMCACGTCANN 0.0475996324426676 551 86 8 0.0930232558139535 0.014519056261343
TF TF:M00797 Factor: HIF1; motif: GNNKACGTGCGGNN 0.0476128767321517 3576 122 35 0.286885245901639 0.00978747203579418
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0480140008945038 6225 126 55 0.436507936507937 0.00883534136546185
TF TF:M02090_1 Factor: E2F-4; motif: GCGGGAAANA; match class: 1 0.0481264822910043 6378 45 24 0.533333333333333 0.00376293508936971
TF TF:M11732 Factor: PXR; motif: NYGAACYNNNYGMMCTN 0.0481661196038514 2795 3 3 1 0.00107334525939177
TF TF:M11387 Factor: elf5; motif: NNNNMGGAAGTN 0.0482136036182961 2598 29 10 0.344827586206897 0.00384911470361817
TF TF:M09918 Factor: Pet-1; motif: GCNGGAAGYG 0.0486447179396925 13610 103 84 0.815533980582524 0.00617193240264511
TF TF:M03811_1 Factor: AP-2gamma; motif: GCCYNCRGSN; match class: 1 0.0486758646678309 3812 140 41 0.292857142857143 0.0107555089192025
TF TF:M12160 Factor: KLF15; motif: RCCMCRCCCMCN 0.0488870839847048 12729 71 57 0.802816901408451 0.00447796370492576
TF TF:M12242 Factor: Blimp-1; motif: NAGKGAAAGTGN 0.0488870839847048 1358 5 3 0.6 0.00220913107511046
TF TF:M11075 Factor: Sohlh2; motif: NNCACGTGNN 0.0488875775286529 11927 88 66 0.75 0.00553366311729689
TF TF:M04696 Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN 0.0488875775286529 7819 92 50 0.543478260869565 0.00639467962655071
TF TF:M10581 Factor: Barhl2; motif: NTAAACGGT 0.0488875775286529 1359 29 7 0.241379310344828 0.00515084621044886
TF TF:M03791 Factor: GABPalpha_GABPbeta; motif: CTTCCKGY 0.0488875775286529 2969 85 23 0.270588235294118 0.00774671606601549
TF TF:M07370 Factor: YY1; motif: NNNNAARATGGNNNN 0.0488875775286529 5811 81 36 0.444444444444444 0.00619514713474445
TF TF:M11432 Factor: Elk-1; motif: NACMGGAAGTN 0.0488875775286529 6140 85 39 0.458823529411765 0.00635179153094463
TF TF:M11081 Factor: SREBP-1; motif: RTCRCGTGAY 0.0488875775286529 11062 67 49 0.73134328358209 0.00442957873802206
TF TF:M00427 Factor: E2F; motif: TTTSGCGS 0.0490080951380651 9485 116 71 0.612068965517241 0.00748550342646284
TF TF:M04515 Factor: E2F-1; motif: WWTGGCGCCAAA 0.0490835669959168 13334 117 93 0.794871794871795 0.00697465126743663
TF TF:M09732 Factor: RFX3; motif: NYNCCMTGGCAACM 0.0492058732272823 5207 37 18 0.486486486486487 0.00345688496255041
TF TF:M10785 Factor: hoxa9; motif: RTCGTWANNN 0.0492058732272823 5632 118 48 0.406779661016949 0.00852272727272727
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.0492333375380196 8319 120 66 0.55 0.00793364587089794
TF TF:M08235 Factor: ERF:TBR2; motif: NNTNRCACCGGAWGY 0.0492400659990321 272 138 7 0.0507246376811594 0.0257352941176471
TF TF:M00246 Factor: Egr-2; motif: NTGCGTRGGCGK 0.049395200439311 6212 39 21 0.538461538461538 0.00338055376690277
WP WP:WP3613 Photodynamic therapy-induced unfolded protein response 7.6729137726243e-07 29 40 6 0.15 0.206896551724138
WP WP:WP4917 Proximal tubule transport 0.019339126656306 58 18 3 0.166666666666667 0.0517241379310345

pEpiTp19 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp19
Possible regulators of activation of pEpiTp19 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.