pP06 program activity among Plasma cells

Activation of pP06
pP06 gene program activation in Plasma cells.
Gene program activation of pP06 by different cell subtypes
pP06 gene program activation among cells of different subtypes (Plasma cells).

pP06 top program genes

Top genes of pP06 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pP06 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pP06
pP06 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0097205 renal filtration 1.4761230468251e-08 26 5 4 0.8 0.153846153846154
GO:BP GO:0003094 glomerular filtration 1.4761230468251e-08 25 5 4 0.8 0.16
GO:BP GO:0045730 respiratory burst 3.4452196120937e-08 35 5 4 0.8 0.114285714285714
GO:BP GO:0060267 positive regulation of respiratory burst 3.7595617802062e-08 9 3 3 1 0.333333333333333
GO:BP GO:0060263 regulation of respiratory burst 2.00509961610997e-07 16 3 3 1 0.1875
GO:BP GO:0003014 renal system process 3.27968360061746e-06 126 5 4 0.8 0.0317460317460317
GO:BP GO:0019731 antibacterial humoral response 9.67255962771418e-06 62 3 3 1 0.0483870967741935
GO:BP GO:0001895 retina homeostasis 1.76965705962455e-05 79 3 3 1 0.0379746835443038
GO:BP GO:0002443 leukocyte mediated immunity 2.19845653000649e-05 877 31 11 0.354838709677419 0.0125427594070696
GO:BP GO:0002283 neutrophil activation involved in immune response 2.9091938097085e-05 485 25 8 0.32 0.0164948453608247
GO:BP GO:0043312 neutrophil degranulation 2.9091938097085e-05 482 25 8 0.32 0.016597510373444
GO:BP GO:0042119 neutrophil activation 3.01287543825357e-05 498 25 8 0.32 0.0160642570281124
GO:BP GO:0002446 neutrophil mediated immunity 3.01287543825357e-05 497 25 8 0.32 0.0160965794768612
GO:BP GO:0036230 granulocyte activation 3.06536458247387e-05 504 25 8 0.32 0.0158730158730159
GO:BP GO:0043299 leukocyte degranulation 4.50662115063785e-05 535 25 8 0.32 0.0149532710280374
GO:BP GO:0019730 antimicrobial humoral response 4.6889932939895e-05 145 3 3 1 0.0206896551724138
GO:BP GO:0002252 immune effector process 4.6889932939895e-05 1309 25 11 0.44 0.00840336134453781
GO:BP GO:0002444 myeloid leukocyte mediated immunity 4.6889932939895e-05 551 25 8 0.32 0.014519056261343
GO:BP GO:0002275 myeloid cell activation involved in immune response 4.6889932939895e-05 547 25 8 0.32 0.0146252285191956
GO:BP GO:0045321 leukocyte activation 4.91363322160005e-05 1332 25 11 0.44 0.00825825825825826
GO:BP GO:0042742 defense response to bacterium 5.63176723326668e-05 349 5 4 0.8 0.0114613180515759
GO:BP GO:0043062 extracellular structure organization 6.78385319630858e-05 402 76 11 0.144736842105263 0.027363184079602
GO:BP GO:0030198 extracellular matrix organization 6.78385319630858e-05 401 76 11 0.144736842105263 0.027431421446384
GO:BP GO:0045229 external encapsulating structure organization 6.82510404225337e-05 404 76 11 0.144736842105263 0.0272277227722772
GO:BP GO:0002376 immune system process 8.98285536518101e-05 3278 21 14 0.666666666666667 0.00427089688834655
GO:BP GO:0016192 vesicle-mediated transport 8.99272155182364e-05 2180 25 13 0.52 0.00596330275229358
GO:BP GO:0045047 protein targeting to ER 8.99272155182364e-05 113 14 4 0.285714285714286 0.0353982300884956
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 9.96693274141121e-05 117 14 4 0.285714285714286 0.0341880341880342
GO:BP GO:0006955 immune response 0.000103557824170207 2311 21 12 0.571428571428571 0.00519255733448724
GO:BP GO:0001775 cell activation 0.000103557824170207 1495 25 11 0.44 0.00735785953177258
GO:BP GO:0006887 exocytosis 0.000104467341592318 904 25 9 0.36 0.00995575221238938
GO:BP GO:0002274 myeloid leukocyte activation 0.000111308970871056 667 25 8 0.32 0.0119940029985007
GO:BP GO:0001894 tissue homeostasis 0.000175996316791315 270 3 3 1 0.0111111111111111
GO:BP GO:0002366 leukocyte activation involved in immune response 0.000179478341197381 717 25 8 0.32 0.0111576011157601
GO:BP GO:0002263 cell activation involved in immune response 0.000181700316061239 721 25 8 0.32 0.0110957004160888
GO:BP GO:0070972 protein localization to endoplasmic reticulum 0.000187502300286093 146 14 4 0.285714285714286 0.0273972602739726
GO:BP GO:0006898 receptor-mediated endocytosis 0.000295104116536013 333 3 3 1 0.00900900900900901
GO:BP GO:0045055 regulated exocytosis 0.000313772274632247 785 25 8 0.32 0.0101910828025478
GO:BP GO:0006959 humoral immune response 0.000429828724446278 384 3 3 1 0.0078125
GO:BP GO:0006810 transport 0.000431135708482196 5224 25 18 0.72 0.00344563552833078
GO:BP GO:0009617 response to bacterium 0.000587448018804361 743 5 4 0.8 0.0053835800807537
GO:BP GO:0051234 establishment of localization 0.000630848791079018 5372 25 18 0.72 0.00335070737155622
GO:BP GO:0060249 anatomical structure homeostasis 0.000772203164781007 482 3 3 1 0.00622406639004149
GO:BP GO:0050900 leukocyte migration 0.000879555048200394 511 3 3 1 0.00587084148727984
GO:BP GO:0051179 localization 0.000886187109228372 6901 25 20 0.8 0.00289813070569483
GO:BP GO:0048871 multicellular organismal homeostasis 0.000939797503503991 530 3 3 1 0.00566037735849057
GO:BP GO:0032940 secretion by cell 0.00117957443906594 1364 35 11 0.314285714285714 0.00806451612903226
GO:BP GO:0045087 innate immune response 0.00155296893652421 998 5 4 0.8 0.00400801603206413
GO:BP GO:0140352 export from cell 0.00162289885028814 1418 35 11 0.314285714285714 0.0077574047954866
GO:BP GO:0006605 protein targeting 0.00184351816988052 441 18 5 0.277777777777778 0.0113378684807256
GO:BP GO:0002250 adaptive immune response 0.00184351816988052 689 3 3 1 0.00435413642960813
GO:BP GO:0006897 endocytosis 0.00185492534638302 696 3 3 1 0.00431034482758621
GO:BP GO:0006958 complement activation, classical pathway 0.0020646453940648 142 54 5 0.0925925925925926 0.0352112676056338
GO:BP GO:0051604 protein maturation 0.00207151137168138 306 26 5 0.192307692307692 0.0163398692810458
GO:BP GO:0046903 secretion 0.00244403242704318 1501 35 11 0.314285714285714 0.00732844770153231
GO:BP GO:0006909 phagocytosis 0.00279837712910611 387 5 3 0.6 0.00775193798449612
GO:BP GO:0098542 defense response to other organism 0.00279837712910611 1218 5 4 0.8 0.00328407224958949
GO:BP GO:0051649 establishment of localization in cell 0.00279837712910611 2813 21 11 0.523809523809524 0.00391041592605759
GO:BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 0.00285835381665289 156 54 5 0.0925925925925926 0.032051282051282
GO:BP GO:0051641 cellular localization 0.00422911790439437 3541 21 12 0.571428571428571 0.00338887319966111
GO:BP GO:0050864 regulation of B cell activation 0.00488499516766387 194 11 3 0.272727272727273 0.0154639175257732
GO:BP GO:0006956 complement activation 0.00502032532008962 180 54 5 0.0925925925925926 0.0277777777777778
GO:BP GO:0072594 establishment of protein localization to organelle 0.00516707443564042 584 18 5 0.277777777777778 0.00856164383561644
GO:BP GO:0042592 homeostatic process 0.00648042597475621 1981 7 5 0.714285714285714 0.00252397778899546
GO:BP GO:0043207 response to external biotic stimulus 0.00648042597475621 1594 5 4 0.8 0.00250941028858218
GO:BP GO:0051707 response to other organism 0.00648042597475621 1592 5 4 0.8 0.00251256281407035
GO:BP GO:0009607 response to biotic stimulus 0.00691555219302356 1626 5 4 0.8 0.002460024600246
GO:BP GO:0009893 positive regulation of metabolic process 0.0073052083110252 3783 11 8 0.727272727272727 0.0021147237642083
GO:BP GO:0030199 collagen fibril organization 0.00950521809621856 58 46 3 0.0652173913043478 0.0517241379310345
GO:BP GO:0016485 protein processing 0.00952157020873868 235 12 3 0.25 0.0127659574468085
GO:BP GO:0006952 defense response 0.00982009853204336 1818 5 4 0.8 0.0022002200220022
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0102794878084843 2255 10 6 0.6 0.00266075388026608
GO:BP GO:0048545 response to steroid hormone 0.0140741353946481 349 56 6 0.107142857142857 0.0171919770773639
GO:BP GO:0016477 cell migration 0.0148386924459594 1649 3 3 1 0.00181928441479685
GO:BP GO:0042113 B cell activation 0.0167298208700092 330 11 3 0.272727272727273 0.00909090909090909
GO:BP GO:0051674 localization of cell 0.0180860390599967 1828 3 3 1 0.00164113785557987
GO:BP GO:0048870 cell motility 0.0180860390599967 1828 3 3 1 0.00164113785557987
GO:BP GO:0031960 response to corticosteroid 0.0180860390599967 165 22 3 0.136363636363636 0.0181818181818182
GO:BP GO:0003008 system process 0.0194412547357344 2293 5 4 0.8 0.00174443959877889
GO:BP GO:0040011 locomotion 0.0219912227563462 2028 3 3 1 0.0014792899408284
GO:BP GO:0006928 movement of cell or subcellular component 0.0291898587848891 2311 3 3 1 0.00129813933362181
GO:BP GO:0034613 cellular protein localization 0.0304022594327157 2014 18 7 0.388888888888889 0.00347567030784508
GO:BP GO:0070727 cellular macromolecule localization 0.0308102124354812 2024 18 7 0.388888888888889 0.00345849802371542
GO:BP GO:0009725 response to hormone 0.031930135280099 921 58 9 0.155172413793103 0.00977198697068404
GO:BP GO:0033365 protein localization to organelle 0.0326641430481202 1017 18 5 0.277777777777778 0.00491642084562439
GO:BP GO:0007160 cell-matrix adhesion 0.0359475814481342 235 46 4 0.0869565217391304 0.0170212765957447
GO:BP GO:0009605 response to external stimulus 0.0361047436885585 2944 5 4 0.8 0.00135869565217391
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0368786151200452 3210 16 8 0.5 0.00249221183800623
GO:BP GO:0032870 cellular response to hormone stimulus 0.0460033192090776 645 58 7 0.120689655172414 0.0108527131782946
GO:BP GO:0048477 oogenesis 0.0488123495485612 89 70 3 0.0428571428571429 0.0337078651685393
GO:BP GO:0071705 nitrogen compound transport 0.0488123495485612 2322 18 7 0.388888888888889 0.00301464254952627
GO:BP GO:0006886 intracellular protein transport 0.0488123495485612 1186 18 5 0.277777777777778 0.00421585160202361
GO:CC GO:0071750 dimeric IgA immunoglobulin complex 1.48796143906394e-10 3 3 3 1 1
GO:CC GO:0071752 secretory dimeric IgA immunoglobulin complex 1.48796143906394e-10 3 3 3 1 1
GO:CC GO:0071748 monomeric IgA immunoglobulin complex 3.9678971708372e-10 4 3 3 1 0.75
GO:CC GO:0071751 secretory IgA immunoglobulin complex 4.25131839732557e-10 5 3 3 1 0.6
GO:CC GO:0071749 polymeric IgA immunoglobulin complex 4.25131839732557e-10 5 3 3 1 0.6
GO:CC GO:0071746 IgA immunoglobulin complex, circulating 4.25131839732557e-10 5 3 3 1 0.6
GO:CC GO:0071745 IgA immunoglobulin complex 4.25131839732557e-10 5 3 3 1 0.6
GO:CC GO:0012505 endomembrane system 9.00565369702536e-08 4640 36 26 0.722222222222222 0.00560344827586207
GO:CC GO:0009986 cell surface 2.63344427442956e-07 899 58 16 0.275862068965517 0.017797552836485
GO:CC GO:0005576 extracellular region 1.49192466226712e-06 4567 83 43 0.518072289156627 0.00941537114079264
GO:CC GO:0042571 immunoglobulin complex, circulating 1.97898871395505e-06 77 3 3 1 0.038961038961039
GO:CC GO:0019814 immunoglobulin complex 3.61700381181467e-06 167 67 8 0.119402985074627 0.0479041916167665
GO:CC GO:0072562 blood microparticle 8.87975707861652e-06 140 3 3 1 0.0214285714285714
GO:CC GO:0070062 extracellular exosome 8.87975707861652e-06 2176 31 15 0.483870967741935 0.00689338235294118
GO:CC GO:0005615 extracellular space 8.87975707861652e-06 3594 61 29 0.475409836065574 0.00806900389538119
GO:CC GO:0071944 cell periphery 1.02198403286745e-05 6169 76 46 0.605263157894737 0.00745663802885395
GO:CC GO:1903561 extracellular vesicle 1.17507931589996e-05 2261 31 15 0.483870967741935 0.00663423264042459
GO:CC GO:0043230 extracellular organelle 1.17507931589996e-05 2263 31 15 0.483870967741935 0.0066283694211224
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 1.67350983117294e-05 128 12 4 0.333333333333333 0.03125
GO:CC GO:0009897 external side of plasma membrane 2.01566821911754e-05 408 38 8 0.210526315789474 0.0196078431372549
GO:CC GO:0031982 vesicle 2.75816554036956e-05 4055 31 19 0.612903225806452 0.00468557336621455
GO:CC GO:0005764 lysosome 0.000119202518055131 712 58 11 0.189655172413793 0.0154494382022472
GO:CC GO:0030141 secretory granule 0.000119202518055131 851 25 8 0.32 0.00940070505287897
GO:CC GO:0000323 lytic vacuole 0.000119202518055131 712 58 11 0.189655172413793 0.0154494382022472
GO:CC GO:0005766 primary lysosome 0.000178095872192429 154 19 4 0.210526315789474 0.025974025974026
GO:CC GO:0042582 azurophil granule 0.000178095872192429 154 19 4 0.210526315789474 0.025974025974026
GO:CC GO:0005783 endoplasmic reticulum 0.000223349391666201 1982 34 13 0.382352941176471 0.0065590312815338
GO:CC GO:0035577 azurophil granule membrane 0.000229373042646845 57 18 3 0.166666666666667 0.0526315789473684
GO:CC GO:0098552 side of membrane 0.000276500183609238 619 38 8 0.210526315789474 0.012924071082391
GO:CC GO:0031224 intrinsic component of membrane 0.000287877533522093 5868 62 35 0.564516129032258 0.00596455351056578
GO:CC GO:0005773 vacuole 0.000299747020379442 810 58 11 0.189655172413793 0.0135802469135802
GO:CC GO:0099503 secretory vesicle 0.000322869333862523 1020 25 8 0.32 0.00784313725490196
GO:CC GO:0016021 integral component of membrane 0.000413183224141531 5711 62 34 0.548387096774194 0.00595342321835055
GO:CC GO:0005886 plasma membrane 0.000482471898573329 5681 70 37 0.528571428571429 0.00651293786305228
GO:CC GO:0070820 tertiary granule 0.00052842224863663 163 25 4 0.16 0.0245398773006135
GO:CC GO:0098796 membrane protein complex 0.00069172216836651 1322 28 9 0.321428571428571 0.00680786686838124
GO:CC GO:0101002 ficolin-1-rich granule 0.00080240555529807 184 25 4 0.16 0.0217391304347826
GO:CC GO:0097708 intracellular vesicle 0.000970637377054199 2428 25 11 0.44 0.00453047775947282
GO:CC GO:0031410 cytoplasmic vesicle 0.000970637377054199 2424 25 11 0.44 0.00453795379537954
GO:CC GO:0030667 secretory granule membrane 0.00123136168620025 303 18 4 0.222222222222222 0.0132013201320132
GO:CC GO:0005788 endoplasmic reticulum lumen 0.00164797015068724 307 76 7 0.0921052631578947 0.0228013029315961
GO:CC GO:0031902 late endosome membrane 0.00208745155017476 140 18 3 0.166666666666667 0.0214285714285714
GO:CC GO:0031012 extracellular matrix 0.00265645928894361 562 76 9 0.118421052631579 0.0160142348754448
GO:CC GO:0005765 lysosomal membrane 0.00265645928894361 383 18 4 0.222222222222222 0.010443864229765
GO:CC GO:0098852 lytic vacuole membrane 0.00265645928894361 383 18 4 0.222222222222222 0.010443864229765
GO:CC GO:0030312 external encapsulating structure 0.00265645928894361 563 76 9 0.118421052631579 0.0159857904085258
GO:CC GO:0005887 integral component of plasma membrane 0.00273783668368442 1645 66 15 0.227272727272727 0.00911854103343465
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.00353816675308211 124 25 3 0.12 0.0241935483870968
GO:CC GO:0005775 vacuolar lumen 0.00406006423377195 174 19 3 0.157894736842105 0.0172413793103448
GO:CC GO:0005774 vacuolar membrane 0.00411568332138508 441 18 4 0.222222222222222 0.0090702947845805
GO:CC GO:0031226 intrinsic component of plasma membrane 0.00422398524173933 1726 66 15 0.227272727272727 0.00869061413673233
GO:CC GO:0034774 secretory granule lumen 0.00443606526407312 320 25 4 0.16 0.0125
GO:CC GO:0031984 organelle subcompartment 0.00445639217394393 1773 18 7 0.388888888888889 0.00394811054709532
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.00449172631422175 324 25 4 0.16 0.0123456790123457
GO:CC GO:0031983 vesicle lumen 0.00452067580353556 326 25 4 0.16 0.0122699386503067
GO:CC GO:0031090 organelle membrane 0.00482735497784168 3612 28 13 0.464285714285714 0.00359911406423034
GO:CC GO:0005789 endoplasmic reticulum membrane 0.00482735497784168 1117 14 5 0.357142857142857 0.0044762757385855
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.00484946203428626 1122 14 5 0.357142857142857 0.00445632798573975
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.00495994616272583 1139 14 5 0.357142857142857 0.00438981562774363
GO:CC GO:0062023 collagen-containing extracellular matrix 0.00535474906038369 421 72 7 0.0972222222222222 0.0166270783847981
GO:CC GO:0032991 protein-containing complex 0.00545978582157244 5548 18 12 0.666666666666667 0.00216294160057678
GO:CC GO:0042581 specific granule 0.00551114022366686 158 25 3 0.12 0.0189873417721519
GO:CC GO:0016020 membrane 0.00761557297193574 9838 62 44 0.709677419354839 0.00447245375076235
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00761557297193574 779 22 5 0.227272727272727 0.00641848523748395
GO:CC GO:0012506 vesicle membrane 0.008053926986543 800 22 5 0.227272727272727 0.00625
GO:CC GO:0043296 apical junction complex 0.008053926986543 145 69 4 0.0579710144927536 0.0275862068965517
GO:CC GO:0005770 late endosome 0.0086387864033627 275 18 3 0.166666666666667 0.0109090909090909
GO:CC GO:0044291 cell-cell contact zone 0.00965788464998283 74 69 3 0.0434782608695652 0.0405405405405405
GO:CC GO:0043202 lysosomal lumen 0.0097043115146084 97 53 3 0.0566037735849057 0.0309278350515464
GO:CC GO:0043227 membrane-bounded organelle 0.0119609494487065 12858 36 32 0.888888888888889 0.00248872297402395
GO:CC GO:0010008 endosome membrane 0.0121137296671326 505 24 4 0.166666666666667 0.00792079207920792
GO:CC GO:0098590 plasma membrane region 0.0121137296671326 1240 66 11 0.166666666666667 0.00887096774193548
GO:CC GO:0031301 integral component of organelle membrane 0.0175226020931852 382 18 3 0.166666666666667 0.00785340314136126
GO:CC GO:0005581 collagen trimer 0.0178682496465314 95 71 3 0.0422535211267606 0.0315789473684211
GO:CC GO:0043226 organelle 0.0184604478878075 14008 31 29 0.935483870967742 0.00207024557395774
GO:CC GO:0005604 basement membrane 0.018599671012438 97 72 3 0.0416666666666667 0.0309278350515464
GO:CC GO:0098797 plasma membrane protein complex 0.0186575559012926 694 60 7 0.116666666666667 0.0100864553314121
GO:CC GO:0005768 endosome 0.019354851030991 987 8 3 0.375 0.00303951367781155
GO:CC GO:0031300 intrinsic component of organelle membrane 0.0194633317432734 413 18 3 0.166666666666667 0.00726392251815981
GO:CC GO:0098588 bounding membrane of organelle 0.0233810554713308 2158 8 4 0.5 0.00185356811862836
GO:CC GO:0005923 bicellular tight junction 0.0278765111844351 123 69 3 0.0434782608695652 0.024390243902439
GO:CC GO:0070161 anchoring junction 0.0288104003199047 836 69 8 0.115942028985507 0.00956937799043062
GO:CC GO:0070160 tight junction 0.0315169994006672 131 69 3 0.0434782608695652 0.0229007633587786
GO:CC GO:0005737 cytoplasm 0.0331873118650923 11911 30 25 0.833333333333333 0.00209890017630761
GO:CC GO:0043025 neuronal cell body 0.0372180549088608 518 35 4 0.114285714285714 0.00772200772200772
GO:CC GO:0005794 Golgi apparatus 0.0447971617456668 1623 19 5 0.263157894736842 0.00308071472581639
GO:MF GO:0034987 immunoglobulin receptor binding 2.14179509356773e-05 79 3 3 1 0.0379746835443038
GO:MF GO:0003823 antigen binding 9.59542023352242e-05 163 3 3 1 0.0184049079754601
GO:MF GO:0030020 extracellular matrix structural constituent conferring tensile strength 0.0247947555799003 41 71 3 0.0422535211267606 0.0731707317073171
GO:MF GO:0005201 extracellular matrix structural constituent 0.0247947555799003 171 71 5 0.0704225352112676 0.0292397660818713
GO:MF GO:0005102 signaling receptor binding 0.0300882309748063 1672 3 3 1 0.00179425837320574
KEGG KEGG:03060 Protein export 0.000658604084402603 23 14 3 0.214285714285714 0.130434782608696
REAC REAC:R-HSA-2168880 Scavenging of heme from plasma 6.15795888111108e-05 67 3 3 1 0.0447761194029851
REAC REAC:R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 8.89629348219382e-05 95 3 3 1 0.0315789473684211
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 0.000363732678056119 113 12 4 0.333333333333333 0.0353982300884956
REAC REAC:R-HSA-202733 Cell surface interactions at the vascular wall 0.000363732678056119 190 3 3 1 0.0157894736842105
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.00043407042952177 474 25 8 0.32 0.0168776371308017
REAC REAC:R-HSA-1474244 Extracellular matrix organization 0.00158896827630788 298 46 8 0.173913043478261 0.0268456375838926
REAC REAC:R-HSA-72766 Translation 0.00549822506737616 292 12 4 0.333333333333333 0.0136986301369863
REAC REAC:R-HSA-109582 Hemostasis 0.00549822506737616 657 3 3 1 0.0045662100456621
REAC REAC:R-HSA-5653656 Vesicle-mediated transport 0.00604922247744691 717 3 3 1 0.00418410041841004
REAC REAC:R-HSA-168249 Innate Immune System 0.0417515324402699 1073 25 8 0.32 0.00745573159366263
REAC REAC:R-HSA-216083 Integrin cell surface interactions 0.0417515324402699 84 71 4 0.0563380281690141 0.0476190476190476
REAC REAC:R-HSA-8948216 Collagen chain trimerization 0.0498979023120032 44 71 3 0.0422535211267606 0.0681818181818182

pP06 transcription factor target enrichment of top program genes

TF enrichment of pP06
TFs corrosponding to activation of pP06. (Left) pearson correlation of TF expression and gene expression program activatity in Plasma cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.