pM01 program activity among Myeloid cells

Activation of pM01
pM01 gene program activation in Myeloid cells.
Gene program activation of pM01 by different cell subtypes
pM01 gene program activation among cells of different subtypes (Myeloid cells).

pM01 top program genes

Top genes of pM01 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pM01 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pM01
pM01 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006954 inflammatory response 1.62480324005632e-06 794 142 26 0.183098591549296 0.0327455919395466
GO:BP GO:0006952 defense response 6.54585798468996e-06 1818 143 39 0.272727272727273 0.0214521452145215
GO:BP GO:0050670 regulation of lymphocyte proliferation 2.04049542307182e-05 230 138 13 0.0942028985507246 0.0565217391304348
GO:BP GO:0032944 regulation of mononuclear cell proliferation 2.04049542307182e-05 232 138 13 0.0942028985507246 0.0560344827586207
GO:BP GO:0070663 regulation of leukocyte proliferation 4.12511846859151e-05 251 138 13 0.0942028985507246 0.051792828685259
GO:BP GO:0042129 regulation of T cell proliferation 5.6002164934037e-05 176 138 11 0.0797101449275362 0.0625
GO:BP GO:0032943 mononuclear cell proliferation 0.000173558780227999 297 138 13 0.0942028985507246 0.0437710437710438
GO:BP GO:0046651 lymphocyte proliferation 0.000173558780227999 294 138 13 0.0942028985507246 0.0442176870748299
GO:BP GO:0042098 T cell proliferation 0.000173558780227999 205 138 11 0.0797101449275362 0.0536585365853659
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.000374840095545853 141 138 9 0.0652173913043478 0.0638297872340425
GO:BP GO:0070661 leukocyte proliferation 0.000374840095545853 325 138 13 0.0942028985507246 0.04
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.000374840095545853 142 138 9 0.0652173913043478 0.0633802816901408
GO:BP GO:0050863 regulation of T cell activation 0.000455199229258904 337 138 13 0.0942028985507246 0.0385756676557863
GO:BP GO:0051249 regulation of lymphocyte activation 0.000486815767337145 518 138 16 0.115942028985507 0.0308880308880309
GO:BP GO:0050865 regulation of cell activation 0.000515880621781172 655 138 18 0.130434782608696 0.0274809160305344
GO:BP GO:0002376 immune system process 0.000515880621781172 3278 139 48 0.345323741007194 0.0146430750457596
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.000547470910754056 155 138 9 0.0652173913043478 0.0580645161290323
GO:BP GO:0050801 ion homeostasis 0.000571464643885935 808 93 16 0.172043010752688 0.0198019801980198
GO:BP GO:0002694 regulation of leukocyte activation 0.000675229098332737 610 138 17 0.123188405797101 0.0278688524590164
GO:BP GO:0009605 response to external stimulus 0.000727346854436411 2944 143 45 0.314685314685315 0.0152853260869565
GO:BP GO:0055080 cation homeostasis 0.000917198649112605 750 93 15 0.161290322580645 0.02
GO:BP GO:0098771 inorganic ion homeostasis 0.00104277512426357 761 93 15 0.161290322580645 0.0197109067017083
GO:BP GO:0006950 response to stress 0.00127779648561874 4170 123 50 0.40650406504065 0.0119904076738609
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.0014476731688593 338 138 12 0.0869565217391304 0.0355029585798817
GO:BP GO:0035556 intracellular signal transduction 0.00159036323084756 2772 102 33 0.323529411764706 0.0119047619047619
GO:BP GO:0042102 positive regulation of T cell proliferation 0.0018019000857682 104 138 7 0.0507246376811594 0.0673076923076923
GO:BP GO:0006955 immune response 0.00200284323099049 2311 138 36 0.260869565217391 0.0155776720034617
GO:BP GO:0032101 regulation of response to external stimulus 0.00252777852798179 1051 142 22 0.154929577464789 0.0209324452901998
GO:BP GO:0042110 T cell activation 0.00252777852798179 489 138 14 0.101449275362319 0.0286298568507157
GO:BP GO:0016192 vesicle-mediated transport 0.0028642303121367 2180 31 13 0.419354838709677 0.00596330275229358
GO:BP GO:0002682 regulation of immune system process 0.00301620003149408 1617 138 28 0.202898550724638 0.0173160173160173
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.00303320703831688 375 138 12 0.0869565217391304 0.032
GO:BP GO:0030003 cellular cation homeostasis 0.00351183660529814 673 93 13 0.139784946236559 0.0193164933135215
GO:BP GO:0006959 humoral immune response 0.00351183660529814 384 138 12 0.0869565217391304 0.03125
GO:BP GO:0045321 leukocyte activation 0.00351183660529814 1332 85 18 0.211764705882353 0.0135135135135135
GO:BP GO:0042592 homeostatic process 0.00375927438107896 1981 87 23 0.264367816091954 0.0116102978293791
GO:BP GO:0006873 cellular ion homeostasis 0.00410441987066547 687 93 13 0.139784946236559 0.0189228529839884
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0041537771759329 3210 87 31 0.35632183908046 0.00965732087227414
GO:BP GO:0007155 cell adhesion 0.00422152697368889 1492 138 26 0.188405797101449 0.017426273458445
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.00422152697368889 2255 143 35 0.244755244755245 0.0155210643015521
GO:BP GO:0002684 positive regulation of immune system process 0.00422152697368889 1065 138 21 0.152173913043478 0.0197183098591549
GO:BP GO:0022610 biological adhesion 0.00430444603201716 1499 138 26 0.188405797101449 0.0173448965977318
GO:BP GO:0002576 platelet degranulation 0.00438153653202076 126 142 7 0.0492957746478873 0.0555555555555556
GO:BP GO:1902105 regulation of leukocyte differentiation 0.00438153653202076 288 85 8 0.0941176470588235 0.0277777777777778
GO:BP GO:0002683 negative regulation of immune system process 0.00506639686592879 420 135 12 0.0888888888888889 0.0285714285714286
GO:BP GO:0002696 positive regulation of leukocyte activation 0.00511217871208308 412 138 12 0.0869565217391304 0.029126213592233
GO:BP GO:0046649 lymphocyte activation 0.00521148255207604 771 138 17 0.123188405797101 0.0220492866407263
GO:BP GO:0055065 metal ion homeostasis 0.00521148255207604 667 87 12 0.137931034482759 0.0179910044977511
GO:BP GO:0002430 complement receptor mediated signaling pathway 0.00531129766729196 12 135 3 0.0222222222222222 0.25
GO:BP GO:0040011 locomotion 0.00531129766729196 2028 118 28 0.23728813559322 0.0138067061143984
GO:BP GO:0050896 response to stimulus 0.00579316063380608 9407 81 59 0.728395061728395 0.00627192516211332
GO:BP GO:0050867 positive regulation of cell activation 0.00594862596774676 424 138 12 0.0869565217391304 0.0283018867924528
GO:BP GO:0050900 leukocyte migration 0.0064093206305817 511 134 13 0.0970149253731343 0.025440313111546
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.0064093206305817 365 138 11 0.0797101449275362 0.0301369863013699
GO:BP GO:0002253 activation of immune response 0.0064093206305817 568 138 14 0.101449275362319 0.0246478873239437
GO:BP GO:0006875 cellular metal ion homeostasis 0.00693366796225048 593 87 11 0.126436781609195 0.0185497470489039
GO:BP GO:0002638 negative regulation of immunoglobulin production 0.00760473353138737 14 135 3 0.0222222222222222 0.214285714285714
GO:BP GO:0045589 regulation of regulatory T cell differentiation 0.00760473353138737 35 138 4 0.0289855072463768 0.114285714285714
GO:BP GO:0030098 lymphocyte differentiation 0.00774367570944862 376 138 11 0.0797101449275362 0.0292553191489362
GO:BP GO:0022407 regulation of cell-cell adhesion 0.00799123342636946 445 138 12 0.0869565217391304 0.0269662921348315
GO:BP GO:0048878 chemical homeostasis 0.00799123342636946 1229 93 17 0.182795698924731 0.0138323840520749
GO:BP GO:0001775 cell activation 0.0083273711704073 1495 85 18 0.211764705882353 0.0120401337792642
GO:BP GO:0042130 negative regulation of T cell proliferation 0.00873663677293976 70 135 5 0.037037037037037 0.0714285714285714
GO:BP GO:0045066 regulatory T cell differentiation 0.00941574696868297 38 138 4 0.0289855072463768 0.105263157894737
GO:BP GO:0050776 regulation of immune response 0.00949231122246173 996 138 19 0.13768115942029 0.0190763052208835
GO:BP GO:0016477 cell migration 0.0106475066305919 1649 144 27 0.1875 0.0163735597331716
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.0114106890892363 760 74 11 0.148648648648649 0.0144736842105263
GO:BP GO:0050870 positive regulation of T cell activation 0.0126499544211071 219 138 8 0.0579710144927536 0.0365296803652968
GO:BP GO:0045840 positive regulation of mitotic nuclear division 0.0142086689160484 43 138 4 0.0289855072463768 0.0930232558139535
GO:BP GO:0051179 localization 0.0143801710274045 6901 121 65 0.537190082644628 0.00941892479350819
GO:BP GO:0051239 regulation of multicellular organismal process 0.0146994830835104 2861 144 39 0.270833333333333 0.0136315973435862
GO:BP GO:0071887 leukocyte apoptotic process 0.0146994830835104 108 102 5 0.0490196078431373 0.0462962962962963
GO:BP GO:0002698 negative regulation of immune effector process 0.0146994830835104 125 135 6 0.0444444444444444 0.048
GO:BP GO:0006810 transport 0.0146994830835104 5224 105 47 0.447619047619048 0.00899693721286371
GO:BP GO:0055082 cellular chemical homeostasis 0.0146994830835104 841 93 13 0.139784946236559 0.0154577883472057
GO:BP GO:0006027 glycosaminoglycan catabolic process 0.0158618766369419 61 43 3 0.0697674418604651 0.0491803278688525
GO:BP GO:1903706 regulation of hemopoiesis 0.0158618766369419 424 138 11 0.0797101449275362 0.0259433962264151
GO:BP GO:0050672 negative regulation of lymphocyte proliferation 0.0162113567050449 85 135 5 0.037037037037037 0.0588235294117647
GO:BP GO:0006898 receptor-mediated endocytosis 0.0162113567050449 333 20 4 0.2 0.012012012012012
GO:BP GO:0031347 regulation of defense response 0.0162113567050449 704 142 15 0.105633802816901 0.0213068181818182
GO:BP GO:0140352 export from cell 0.0162258316939924 1418 105 19 0.180952380952381 0.0133991537376587
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0162258316939924 363 50 6 0.12 0.0165289256198347
GO:BP GO:1903131 mononuclear cell differentiation 0.0162258316939924 430 138 11 0.0797101449275362 0.0255813953488372
GO:BP GO:2001234 negative regulation of apoptotic signaling pathway 0.0162258316939924 236 50 5 0.1 0.0211864406779661
GO:BP GO:0045619 regulation of lymphocyte differentiation 0.0162258316939924 180 138 7 0.0507246376811594 0.0388888888888889
GO:BP GO:0032945 negative regulation of mononuclear cell proliferation 0.0162258316939924 86 135 5 0.037037037037037 0.0581395348837209
GO:BP GO:0048870 cell motility 0.0168635518351955 1828 144 28 0.194444444444444 0.0153172866520788
GO:BP GO:0051674 localization of cell 0.0168635518351955 1828 144 28 0.194444444444444 0.0153172866520788
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.0171058006587556 241 138 8 0.0579710144927536 0.033195020746888
GO:BP GO:0045785 positive regulation of cell adhesion 0.0171058006587556 437 138 11 0.0797101449275362 0.0251716247139588
GO:BP GO:0006026 aminoglycan catabolic process 0.0173149893686893 67 43 3 0.0697674418604651 0.0447761194029851
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.017650778002849 512 138 12 0.0869565217391304 0.0234375
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0184000240724952 515 138 12 0.0869565217391304 0.0233009708737864
GO:BP GO:0070664 negative regulation of leukocyte proliferation 0.0195459182903375 92 135 5 0.037037037037037 0.0543478260869565
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.0212218375025194 142 135 6 0.0444444444444444 0.0422535211267606
GO:BP GO:0051234 establishment of localization 0.0214456891771426 5372 105 47 0.447619047619048 0.00874906924795235
GO:BP GO:0050864 regulation of B cell activation 0.0214456891771426 194 138 7 0.0507246376811594 0.0360824742268041
GO:BP GO:0031348 negative regulation of defense response 0.0214456891771426 246 142 8 0.0563380281690141 0.032520325203252
GO:BP GO:0006887 exocytosis 0.0214456891771426 904 142 17 0.119718309859155 0.0188053097345133
GO:BP GO:0006928 movement of cell or subcellular component 0.0219351606959438 2311 118 28 0.23728813559322 0.0121159671138035
GO:BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 0.0223719550357932 93 142 5 0.0352112676056338 0.0537634408602151
GO:BP GO:0006897 endocytosis 0.0223719550357932 696 20 5 0.25 0.00718390804597701
GO:BP GO:0032940 secretion by cell 0.0223719550357932 1364 105 18 0.171428571428571 0.0131964809384164
GO:BP GO:0003094 glomerular filtration 0.0223719550357932 25 133 3 0.0225563909774436 0.12
GO:BP GO:0080134 regulation of response to stress 0.0223719550357932 1443 142 23 0.161971830985915 0.0159390159390159
GO:BP GO:0050727 regulation of inflammatory response 0.0225508852439661 381 142 10 0.0704225352112676 0.026246719160105
GO:BP GO:0030217 T cell differentiation 0.0225508852439661 260 138 8 0.0579710144927536 0.0307692307692308
GO:BP GO:0072583 clathrin-dependent endocytosis 0.0227301128263442 46 74 3 0.0405405405405405 0.0652173913043478
GO:BP GO:0097205 renal filtration 0.022891612059601 26 133 3 0.0225563909774436 0.115384615384615
GO:BP GO:0051785 positive regulation of nuclear division 0.0237863061178294 57 138 4 0.0289855072463768 0.0701754385964912
GO:BP GO:0030334 regulation of cell migration 0.0242252180026064 999 144 18 0.125 0.018018018018018
GO:BP GO:0051707 response to other organism 0.0245992691130155 1592 123 22 0.178861788617886 0.0138190954773869
GO:BP GO:0033674 positive regulation of kinase activity 0.0245992691130155 608 142 13 0.0915492957746479 0.0213815789473684
GO:BP GO:0043207 response to external biotic stimulus 0.0247926999258357 1594 123 22 0.178861788617886 0.013801756587202
GO:BP GO:0050866 negative regulation of cell activation 0.0248657221268738 211 135 7 0.0518518518518519 0.033175355450237
GO:BP GO:0002521 leukocyte differentiation 0.0248657221268738 550 138 12 0.0869565217391304 0.0218181818181818
GO:BP GO:0002757 immune response-activating signal transduction 0.0252130183544856 477 138 11 0.0797101449275362 0.0230607966457023
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0252130183544856 477 138 11 0.0797101449275362 0.0230607966457023
GO:BP GO:0045580 regulation of T cell differentiation 0.0252495093919909 152 138 6 0.0434782608695652 0.0394736842105263
GO:BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0252495093919909 152 138 6 0.0434782608695652 0.0394736842105263
GO:BP GO:1903902 positive regulation of viral life cycle 0.0252495093919909 34 109 3 0.0275229357798165 0.0882352941176471
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.0252871493779447 156 135 6 0.0444444444444444 0.0384615384615385
GO:BP GO:0097190 apoptotic signaling pathway 0.0267656337916892 600 50 7 0.14 0.0116666666666667
GO:BP GO:0005975 carbohydrate metabolic process 0.0275015744796069 635 140 13 0.0928571428571429 0.0204724409448819
GO:BP GO:0098609 cell-cell adhesion 0.0275015744796069 894 138 16 0.115942028985507 0.0178970917225951
GO:BP GO:0097529 myeloid leukocyte migration 0.0275015744796069 221 134 7 0.0522388059701493 0.0316742081447964
GO:BP GO:0045055 regulated exocytosis 0.0275015744796069 785 142 15 0.105633802816901 0.0191082802547771
GO:BP GO:0009607 response to biotic stimulus 0.0276432200100422 1626 123 22 0.178861788617886 0.013530135301353
GO:BP GO:0050690 regulation of defense response to virus by virus 0.0283470107751517 29 138 3 0.0217391304347826 0.103448275862069
GO:BP GO:0032102 negative regulation of response to external stimulus 0.0283779416005888 406 142 10 0.0704225352112676 0.0246305418719212
GO:BP GO:0030449 regulation of complement activation 0.0284093226990577 110 135 5 0.037037037037037 0.0454545454545455
GO:BP GO:0019725 cellular homeostasis 0.0290623273759483 981 93 13 0.139784946236559 0.0132517838939857
GO:BP GO:0007165 signal transduction 0.0290623273759483 6309 103 51 0.495145631067961 0.00808368996671422
GO:BP GO:0042742 defense response to bacterium 0.0290623273759483 349 26 4 0.153846153846154 0.0114613180515759
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.0296618299704222 284 138 8 0.0579710144927536 0.028169014084507
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0311822852327532 1103 74 12 0.162162162162162 0.0108794197642792
GO:BP GO:0007154 cell communication 0.0311822852327532 6829 103 54 0.524271844660194 0.00790745350710207
GO:BP GO:0006874 cellular calcium ion homeostasis 0.031494039797412 460 87 8 0.0919540229885057 0.0173913043478261
GO:BP GO:0048583 regulation of response to stimulus 0.031494039797412 4278 144 50 0.347222222222222 0.0116877045348294
GO:BP GO:0002637 regulation of immunoglobulin production 0.0319626388714267 67 138 4 0.0289855072463768 0.0597014925373134
GO:BP GO:0009611 response to wounding 0.0319626388714267 674 120 12 0.1 0.0178041543026706
GO:BP GO:0030155 regulation of cell adhesion 0.0319626388714267 748 138 14 0.101449275362319 0.018716577540107
GO:BP GO:0002819 regulation of adaptive immune response 0.0324833931899989 167 138 6 0.0434782608695652 0.0359281437125748
GO:BP GO:1901700 response to oxygen-containing compound 0.0325993378891483 1739 118 22 0.186440677966102 0.0126509488211616
GO:BP GO:0050778 positive regulation of immune response 0.0332293222097733 753 138 14 0.101449275362319 0.0185922974767596
GO:BP GO:0032103 positive regulation of response to external stimulus 0.0337432953858899 513 138 11 0.0797101449275362 0.0214424951267057
GO:BP GO:2000145 regulation of cell motility 0.0337432953858899 1061 144 18 0.125 0.0169651272384543
GO:BP GO:0019318 hexose metabolic process 0.0337432953858899 253 38 4 0.105263157894737 0.0158102766798419
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0337432953858899 363 138 9 0.0652173913043478 0.0247933884297521
GO:BP GO:0055074 calcium ion homeostasis 0.0339335878701656 472 87 8 0.0919540229885057 0.0169491525423729
GO:BP GO:0010906 regulation of glucose metabolic process 0.0346678006462494 120 38 3 0.0789473684210526 0.025
GO:BP GO:0050869 negative regulation of B cell activation 0.034927574984451 34 135 3 0.0222222222222222 0.0882352941176471
GO:BP GO:0008037 cell recognition 0.0352628574529358 235 20 3 0.15 0.0127659574468085
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0353232957019579 1160 144 19 0.131944444444444 0.0163793103448276
GO:BP GO:0043648 dicarboxylic acid metabolic process 0.0353232957019579 99 99 4 0.0404040404040404 0.0404040404040404
GO:BP GO:0048584 positive regulation of response to stimulus 0.035768996190683 2344 142 31 0.21830985915493 0.0132252559726962
GO:BP GO:0016032 viral process 0.035768996190683 942 138 16 0.115942028985507 0.0169851380042463
GO:BP GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 0.036644247886859 102 98 4 0.0408163265306122 0.0392156862745098
GO:BP GO:0050868 negative regulation of T cell activation 0.036644247886859 123 135 5 0.037037037037037 0.040650406504065
GO:BP GO:0006956 complement activation 0.0366988735724298 180 135 6 0.0444444444444444 0.0333333333333333
GO:BP GO:0050728 negative regulation of inflammatory response 0.0366988735724298 171 142 6 0.0422535211267606 0.0350877192982456
GO:BP GO:0002250 adaptive immune response 0.0370091008539655 689 138 13 0.0942028985507246 0.0188679245283019
GO:BP GO:0048871 multicellular organismal homeostasis 0.0370091008539655 530 47 6 0.127659574468085 0.0113207547169811
GO:BP GO:0046903 secretion 0.0370091008539655 1501 105 18 0.171428571428571 0.0119920053297801
GO:BP GO:0002761 regulation of myeloid leukocyte differentiation 0.037570157426377 123 83 4 0.0481927710843374 0.032520325203252
GO:BP GO:0001816 cytokine production 0.0382752813900945 844 142 15 0.105633802816901 0.0177725118483412
GO:BP GO:0002701 negative regulation of production of molecular mediator of immune response 0.0382752813900945 37 135 3 0.0222222222222222 0.0810810810810811
GO:BP GO:0006575 cellular modified amino acid metabolic process 0.0382752813900945 199 125 6 0.048 0.0301507537688442
GO:BP GO:0005996 monosaccharide metabolic process 0.0382752813900945 276 38 4 0.105263157894737 0.0144927536231884
GO:BP GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 0.0386290670442846 100 50 3 0.06 0.03
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.0386290670442846 497 87 8 0.0919540229885057 0.0160965794768612
GO:BP GO:0002697 regulation of immune effector process 0.0399894606758075 461 138 10 0.072463768115942 0.0216919739696312
GO:BP GO:2000026 regulation of multicellular organismal development 0.0399894606758075 1447 85 15 0.176470588235294 0.0103662750518314
GO:BP GO:0023052 signaling 0.0399894606758075 6810 103 53 0.514563106796116 0.00778267254038179
GO:BP GO:0002695 negative regulation of leukocyte activation 0.0404035054682462 188 135 6 0.0444444444444444 0.0319148936170213
GO:BP GO:0040012 regulation of locomotion 0.0409124092795621 1104 144 18 0.125 0.016304347826087
GO:BP GO:0071674 mononuclear cell migration 0.0413215483254735 191 134 6 0.0447761194029851 0.031413612565445
GO:BP GO:0051347 positive regulation of transferase activity 0.04149390553952 689 142 13 0.0915492957746479 0.0188679245283019
GO:BP GO:0009617 response to bacterium 0.0422584286468339 743 117 12 0.102564102564103 0.0161507402422611
GO:BP GO:0060326 cell chemotaxis 0.0423175918839181 310 142 8 0.0563380281690141 0.0258064516129032
GO:BP GO:0001818 negative regulation of cytokine production 0.0423905312671936 381 142 9 0.0633802816901408 0.0236220472440945
GO:BP GO:0030212 hyaluronan metabolic process 0.0426233138016045 38 142 3 0.0211267605633803 0.0789473684210526
GO:BP GO:0002920 regulation of humoral immune response 0.0426233138016045 133 135 5 0.037037037037037 0.037593984962406
GO:BP GO:0045860 positive regulation of protein kinase activity 0.0426233138016045 534 142 11 0.0774647887323944 0.0205992509363296
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0427468695413539 982 138 16 0.115942028985507 0.0162932790224033
GO:BP GO:0002573 myeloid leukocyte differentiation 0.0427468695413539 213 85 5 0.0588235294117647 0.0234741784037559
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.0427725683506158 194 135 6 0.0444444444444444 0.0309278350515464
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.0427725683506158 516 87 8 0.0919540229885057 0.0155038759689922
GO:BP GO:0003179 heart valve morphogenesis 0.0433728693036047 54 102 3 0.0294117647058824 0.0555555555555556
GO:BP GO:0061024 membrane organization 0.0433728693036047 973 20 5 0.25 0.00513874614594039
GO:BP GO:0043066 negative regulation of apoptotic process 0.0433728693036047 921 50 8 0.16 0.00868621064060804
GO:BP GO:0006935 chemotaxis 0.0438076645488815 653 118 11 0.0932203389830508 0.0168453292496172
GO:BP GO:0035850 epithelial cell differentiation involved in kidney development 0.0440307995601561 48 118 3 0.0254237288135593 0.0625
GO:BP GO:0030595 leukocyte chemotaxis 0.0440307995601561 227 118 6 0.0508474576271186 0.026431718061674
GO:BP GO:0031952 regulation of protein autophosphorylation 0.0440307995601561 48 118 3 0.0254237288135593 0.0625
GO:BP GO:1905521 regulation of macrophage migration 0.0440307995601561 42 134 3 0.0223880597014925 0.0714285714285714
GO:BP GO:0042330 taxis 0.0440307995601561 656 118 11 0.0932203389830508 0.0167682926829268
GO:BP GO:0010675 regulation of cellular carbohydrate metabolic process 0.0440307995601561 149 38 3 0.0789473684210526 0.0201342281879195
GO:BP GO:0042113 B cell activation 0.0443221551219036 330 138 8 0.0579710144927536 0.0242424242424242
GO:BP GO:0071417 cellular response to organonitrogen compound 0.0444414935312437 666 117 11 0.094017094017094 0.0165165165165165
GO:BP GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 0.0444414935312437 49 117 3 0.0256410256410256 0.0612244897959184
GO:BP GO:0042398 cellular modified amino acid biosynthetic process 0.044563317345003 46 125 3 0.024 0.0652173913043478
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0446052038699149 1001 138 16 0.115942028985507 0.015984015984016
GO:BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 0.0446052038699149 133 142 5 0.0352112676056338 0.037593984962406
GO:BP GO:0043069 negative regulation of programmed cell death 0.0447007762324621 943 50 8 0.16 0.00848356309650053
GO:BP GO:0002707 negative regulation of lymphocyte mediated immunity 0.0447007762324621 43 135 3 0.0222222222222222 0.0697674418604651
GO:BP GO:0046718 viral entry into host cell 0.0455606111872006 141 135 5 0.037037037037037 0.0354609929078014
GO:BP GO:0051270 regulation of cellular component movement 0.0456557574729606 1141 144 18 0.125 0.0157756354075372
GO:BP GO:0048016 inositol phosphate-mediated signaling 0.0461163822703969 60 98 3 0.0306122448979592 0.05
GO:BP GO:0010243 response to organonitrogen compound 0.0461990602903467 1085 117 15 0.128205128205128 0.0138248847926267
GO:BP GO:0001817 regulation of cytokine production 0.0474368958919282 806 142 14 0.0985915492957746 0.0173697270471464
GO:BP GO:0009636 response to toxic substance 0.0474368958919282 243 80 5 0.0625 0.0205761316872428
GO:BP GO:0048146 positive regulation of fibroblast proliferation 0.04772547825731 51 118 3 0.0254237288135593 0.0588235294117647
GO:BP GO:0008038 neuron recognition 0.0481263128491292 47 129 3 0.0232558139534884 0.0638297872340425
GO:BP GO:0050829 defense response to Gram-negative bacterium 0.0489187493691615 88 70 3 0.0428571428571429 0.0340909090909091
GO:BP GO:0071621 granulocyte chemotaxis 0.0489187493691615 126 98 4 0.0408163265306122 0.0317460317460317
GO:BP GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0489187493691615 46 135 3 0.0222222222222222 0.0652173913043478
GO:CC GO:0031982 vesicle 7.13773851238916e-07 4055 142 62 0.436619718309859 0.0152897657213317
GO:CC GO:0031410 cytoplasmic vesicle 3.6895617041845e-06 2424 135 41 0.303703703703704 0.0169141914191419
GO:CC GO:0031226 intrinsic component of plasma membrane 3.6895617041845e-06 1726 138 34 0.246376811594203 0.0196987253765933
GO:CC GO:0097708 intracellular vesicle 3.6895617041845e-06 2428 135 41 0.303703703703704 0.0168863261943987
GO:CC GO:0031224 intrinsic component of membrane 3.6895617041845e-06 5868 90 53 0.588888888888889 0.00903203817314247
GO:CC GO:0071944 cell periphery 3.6895617041845e-06 6169 139 77 0.553956834532374 0.0124817636569947
GO:CC GO:0009986 cell surface 6.91623602471538e-06 899 138 23 0.166666666666667 0.0255839822024472
GO:CC GO:0005886 plasma membrane 8.77326324557085e-06 5681 120 63 0.525 0.0110895969019539
GO:CC GO:0009897 external side of plasma membrane 1.0650083224483e-05 408 85 12 0.141176470588235 0.0294117647058824
GO:CC GO:0016021 integral component of membrane 1.56616241695221e-05 5711 90 50 0.555555555555556 0.00875503414463316
GO:CC GO:0005887 integral component of plasma membrane 2.14030081040278e-05 1645 138 31 0.22463768115942 0.0188449848024316
GO:CC GO:0000323 lytic vacuole 5.42492826481661e-05 712 106 16 0.150943396226415 0.0224719101123595
GO:CC GO:0005764 lysosome 5.42492826481661e-05 712 106 16 0.150943396226415 0.0224719101123595
GO:CC GO:0016020 membrane 5.42492826481661e-05 9838 121 88 0.727272727272727 0.0089449075015247
GO:CC GO:0005576 extracellular region 7.18548858116868e-05 4567 49 27 0.551020408163265 0.00591197722793957
GO:CC GO:0031093 platelet alpha granule lumen 0.000223022302003533 66 142 6 0.0422535211267606 0.0909090909090909
GO:CC GO:0005773 vacuole 0.00022568282411805 810 106 16 0.150943396226415 0.0197530864197531
GO:CC GO:0098552 side of membrane 0.000307468269360041 619 70 11 0.157142857142857 0.0177705977382876
GO:CC GO:0012505 endomembrane system 0.000388321782002316 4640 135 55 0.407407407407407 0.0118534482758621
GO:CC GO:0005615 extracellular space 0.000388321782002316 3594 65 27 0.415384615384615 0.00751252086811352
GO:CC GO:0070062 extracellular exosome 0.000415395478770813 2176 65 20 0.307692307692308 0.00919117647058824
GO:CC GO:0098588 bounding membrane of organelle 0.000442597283945029 2158 121 30 0.247933884297521 0.0139017608897127
GO:CC GO:0005768 endosome 0.000529297519298736 987 117 18 0.153846153846154 0.0182370820668693
GO:CC GO:0043230 extracellular organelle 0.000616859179453288 2263 65 20 0.307692307692308 0.00883782589482987
GO:CC GO:1903561 extracellular vesicle 0.000616859179453288 2261 65 20 0.307692307692308 0.00884564352056612
GO:CC GO:0031091 platelet alpha granule 0.000811814397929984 90 142 6 0.0422535211267606 0.0666666666666667
GO:CC GO:0010008 endosome membrane 0.00309567714280759 505 114 11 0.0964912280701754 0.0217821782178218
GO:CC GO:0098791 Golgi apparatus subcompartment 0.00367817375191959 885 140 17 0.121428571428571 0.0192090395480226
GO:CC GO:0034774 secretory granule lumen 0.00393636256909271 320 55 6 0.109090909090909 0.01875
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.00406578060812259 324 55 6 0.109090909090909 0.0185185185185185
GO:CC GO:0031983 vesicle lumen 0.00406578060812259 326 55 6 0.109090909090909 0.0184049079754601
GO:CC GO:0005770 late endosome 0.00631183437596521 275 128 8 0.0625 0.0290909090909091
GO:CC GO:0005765 lysosomal membrane 0.00715288277629461 383 119 9 0.0756302521008403 0.0234986945169713
GO:CC GO:0098852 lytic vacuole membrane 0.00715288277629461 383 119 9 0.0756302521008403 0.0234986945169713
GO:CC GO:0030666 endocytic vesicle membrane 0.00748055961749166 159 49 4 0.0816326530612245 0.0251572327044025
GO:CC GO:0018995 host cellular component 0.00768154700757081 198 18 3 0.166666666666667 0.0151515151515152
GO:CC GO:0043657 host cell 0.00768154700757081 198 18 3 0.166666666666667 0.0151515151515152
GO:CC GO:0030139 endocytic vesicle 0.00917591715901008 306 71 6 0.0845070422535211 0.0196078431372549
GO:CC GO:0005737 cytoplasm 0.0115017214114491 11911 108 83 0.768518518518518 0.00696834858534128
GO:CC GO:0005766 primary lysosome 0.0124478617001043 154 28 3 0.107142857142857 0.0194805194805195
GO:CC GO:0042582 azurophil granule 0.0124478617001043 154 28 3 0.107142857142857 0.0194805194805195
GO:CC GO:0005794 Golgi apparatus 0.0124478617001043 1623 7 4 0.571428571428571 0.00246457178065311
GO:CC GO:0099503 secretory vesicle 0.012780244944412 1020 142 17 0.119718309859155 0.0166666666666667
GO:CC GO:0000139 Golgi membrane 0.0130819333481568 771 140 14 0.1 0.0181582360570687
GO:CC GO:0098590 plasma membrane region 0.0131096881193449 1240 9 4 0.444444444444444 0.0032258064516129
GO:CC GO:0005774 vacuolar membrane 0.0136123614545837 441 119 9 0.0756302521008403 0.0204081632653061
GO:CC GO:0072562 blood microparticle 0.0157465209193247 140 123 5 0.040650406504065 0.0357142857142857
GO:CC GO:0005905 clathrin-coated pit 0.0178783623286233 71 74 3 0.0405405405405405 0.0422535211267606
GO:CC GO:0030141 secretory granule 0.0194417272408234 851 55 8 0.145454545454545 0.00940070505287897
GO:CC GO:0005788 endoplasmic reticulum lumen 0.0195133860405481 307 118 7 0.0593220338983051 0.0228013029315961
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0216482754077247 779 49 7 0.142857142857143 0.00898587933247754
GO:CC GO:0031984 organelle subcompartment 0.0230942255279815 1773 121 21 0.173553719008264 0.011844331641286
GO:CC GO:0012506 vesicle membrane 0.0233985365188583 800 49 7 0.142857142857143 0.00875
GO:CC GO:0005795 Golgi stack 0.0249748319136532 149 140 5 0.0357142857142857 0.0335570469798658
GO:CC GO:0043202 lysosomal lumen 0.0249748319136532 97 139 4 0.0287769784172662 0.0412371134020619
GO:CC GO:0005783 endoplasmic reticulum 0.0283739107624578 1982 121 22 0.181818181818182 0.0110998990918264
GO:CC GO:0005775 vacuolar lumen 0.028811734605782 174 43 3 0.0697674418604651 0.0172413793103448
GO:CC GO:0030136 clathrin-coated vesicle 0.0289620466600176 193 119 5 0.0420168067226891 0.0259067357512953
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0289620466600176 421 55 5 0.0909090909090909 0.0118764845605701
GO:CC GO:0031090 organelle membrane 0.0289620466600176 3612 73 23 0.315068493150685 0.00636766334440753
GO:CC GO:0030665 clathrin-coated vesicle membrane 0.0333038313298313 114 70 3 0.0428571428571429 0.0263157894736842
GO:CC GO:0031902 late endosome membrane 0.0382967987582726 140 114 4 0.0350877192982456 0.0285714285714286
GO:CC GO:0031985 Golgi cisterna 0.0390435654819663 115 140 4 0.0285714285714286 0.0347826086956522
GO:CC GO:0030135 coated vesicle 0.0399304024566599 295 119 6 0.0504201680672269 0.0203389830508475
GO:CC GO:0043235 receptor complex 0.0431075972657241 522 134 9 0.0671641791044776 0.0172413793103448
GO:MF GO:0038024 cargo receptor activity 9.33390578023666e-05 78 31 5 0.161290322580645 0.0641025641025641
GO:MF GO:0140375 immune receptor activity 0.00148886954750628 133 135 8 0.0592592592592593 0.0601503759398496
GO:MF GO:0033218 amide binding 0.00467676858410665 389 18 5 0.277777777777778 0.012853470437018
GO:MF GO:0004875 complement receptor activity 0.00704935474466705 11 135 3 0.0222222222222222 0.272727272727273
GO:MF GO:0140312 cargo adaptor activity 0.00704935474466705 17 101 3 0.0297029702970297 0.176470588235294
GO:MF GO:0005044 scavenger receptor activity 0.00704935474466705 48 31 3 0.0967741935483871 0.0625
GO:MF GO:0035615 clathrin adaptor activity 0.00704935474466705 16 101 3 0.0297029702970297 0.1875
GO:MF GO:0060089 molecular transducer activity 0.00731067628733788 1458 138 24 0.173913043478261 0.0164609053497942
GO:MF GO:0038023 signaling receptor activity 0.00731067628733788 1458 138 24 0.173913043478261 0.0164609053497942
GO:MF GO:0004364 glutathione transferase activity 0.0167696250070788 25 122 3 0.0245901639344262 0.12
GO:MF GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 0.0253168383312363 57 68 3 0.0441176470588235 0.0526315789473684
GO:MF GO:0004896 cytokine receptor activity 0.0253168383312363 99 87 4 0.0459770114942529 0.0404040404040404
GO:MF GO:0019838 growth factor binding 0.0281480227301434 138 118 5 0.0423728813559322 0.036231884057971
GO:MF GO:0050699 WW domain binding 0.0281480227301434 33 137 3 0.0218978102189781 0.0909090909090909
GO:MF GO:0004888 transmembrane signaling receptor activity 0.0291029919372829 1269 135 19 0.140740740740741 0.0149724192277384
GO:MF GO:0001618 virus receptor activity 0.0293437954368465 76 135 4 0.0296296296296296 0.0526315789473684
GO:MF GO:0140272 exogenous protein binding 0.0293437954368465 77 135 4 0.0296296296296296 0.051948051948052
GO:MF GO:0051287 NAD binding 0.0330320015194563 55 99 3 0.0303030303030303 0.0545454545454545
GO:MF GO:0042277 peptide binding 0.0330320015194563 314 18 3 0.166666666666667 0.00955414012738853
GO:MF GO:0019955 cytokine binding 0.0334832583708182 138 85 4 0.0470588235294118 0.0289855072463768
GO:MF GO:0005178 integrin binding 0.034394317171624 147 133 5 0.037593984962406 0.0340136054421769
GO:MF GO:0015026 coreceptor activity 0.0375789463268482 47 138 3 0.0217391304347826 0.0638297872340425
GO:MF GO:0042802 identical protein binding 0.0390572816826983 2067 73 16 0.219178082191781 0.00774068698597
GO:MF GO:0016491 oxidoreductase activity 0.0393614587714278 771 125 12 0.096 0.0155642023346304
GO:MF GO:0030276 clathrin binding 0.0407488372853172 70 101 3 0.0297029702970297 0.0428571428571429
GO:MF GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 0.0407488372853172 58 122 3 0.0245901639344262 0.0517241379310345
GO:MF GO:0005102 signaling receptor binding 0.0413333482699552 1672 133 21 0.157894736842105 0.0125598086124402
GO:MF GO:0008083 growth factor activity 0.0421090755000149 163 47 3 0.0638297872340425 0.0184049079754601
GO:MF GO:0005518 collagen binding 0.0487083941361296 70 120 3 0.025 0.0428571428571429
REAC REAC:R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 0.0271657735247998 10 135 3 0.0222222222222222 0.3
REAC REAC:R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.0496942328477523 95 20 3 0.15 0.0315789473684211
REAC REAC:R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi 0.0496942328477523 26 73 3 0.0410958904109589 0.115384615384615
TF TF:M04897_1 Factor: Fra-1; motif: ACTCATG; match class: 1 0.00652272859619625 218 31 6 0.193548387096774 0.0275229357798165
TF TF:M03581 Factor: TBP; motif: NGNNTATAAAA 0.00859574558078464 7052 31 24 0.774193548387097 0.00340328984685196
TF TF:M01878 Factor: GATA-3; motif: AGATAA 0.0161956578611154 10147 103 75 0.728155339805825 0.00739134719621563
TF TF:M11641_1 Factor: Sox-30; motif: NAACAATN; match class: 1 0.0417530922973728 236 129 9 0.0697674418604651 0.038135593220339
TF TF:M08369 Factor: HOXD12:PEA3; motif: RCCGGAAGTAATAAAM 0.0435285989064032 4596 31 18 0.580645161290323 0.00391644908616188

pM01 transcription factor target enrichment of top program genes

TF enrichment of pM01
TFs corrosponding to activation of pM01. (Left) pearson correlation of TF expression and gene expression program activatity in Myeloid cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.