pEpi23 program activity among Epithelial cells

Activation of pEpi23
pEpi23 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi23 by different cell subtypes
pEpi23 gene program activation among cells of different subtypes (Epithelial cells).

pEpi23 top program genes

Top genes of pEpi23 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi23 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi23
pEpi23 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.00176320842904005 551 48 9 0.1875 0.0163339382940109
GO:BP GO:0002446 neutrophil mediated immunity 0.00176320842904005 497 48 9 0.1875 0.0181086519114688
GO:BP GO:0140352 export from cell 0.00176320842904005 1418 48 14 0.291666666666667 0.00987306064880113
GO:BP GO:0001890 placenta development 0.00176320842904005 147 17 4 0.235294117647059 0.0272108843537415
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.00176320842904005 547 48 9 0.1875 0.0164533820840951
GO:BP GO:0090087 regulation of peptide transport 0.00176320842904005 618 10 5 0.5 0.00809061488673139
GO:BP GO:0072594 establishment of protein localization to organelle 0.00176320842904005 584 10 5 0.5 0.00856164383561644
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.00176320842904005 1853 74 21 0.283783783783784 0.011332973556395
GO:BP GO:0016032 viral process 0.00176320842904005 942 71 15 0.211267605633803 0.0159235668789809
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00176320842904005 485 48 9 0.1875 0.0185567010309278
GO:BP GO:1900034 regulation of cellular response to heat 0.00176320842904005 79 10 3 0.3 0.0379746835443038
GO:BP GO:1904589 regulation of protein import 0.00176320842904005 65 8 3 0.375 0.0461538461538462
GO:BP GO:0051223 regulation of protein transport 0.00176320842904005 586 10 5 0.5 0.00853242320819113
GO:BP GO:0043299 leukocyte degranulation 0.00176320842904005 535 48 9 0.1875 0.0168224299065421
GO:BP GO:0043312 neutrophil degranulation 0.00176320842904005 482 48 9 0.1875 0.0186721991701245
GO:BP GO:0070201 regulation of establishment of protein localization 0.00176320842904005 611 10 5 0.5 0.00818330605564648
GO:BP GO:0036230 granulocyte activation 0.00176320842904005 504 48 9 0.1875 0.0178571428571429
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.00176320842904005 1001 71 15 0.211267605633803 0.014985014985015
GO:BP GO:0042119 neutrophil activation 0.00176320842904005 498 48 9 0.1875 0.0180722891566265
GO:BP GO:0043603 cellular amide metabolic process 0.00243473778752657 1241 49 13 0.26530612244898 0.0104754230459307
GO:BP GO:0043604 amide biosynthetic process 0.00261571727883431 932 47 11 0.234042553191489 0.0118025751072961
GO:BP GO:0046903 secretion 0.00268247918100828 1501 42 13 0.30952380952381 0.00866089273817455
GO:BP GO:0042592 homeostatic process 0.00321220520574351 1981 63 19 0.301587301587302 0.00959111559818274
GO:BP GO:0034605 cellular response to heat 0.00330074373015466 118 10 3 0.3 0.0254237288135593
GO:BP GO:0046822 regulation of nucleocytoplasmic transport 0.00330074373015466 115 10 3 0.3 0.0260869565217391
GO:BP GO:0032940 secretion by cell 0.00346084320546184 1364 48 13 0.270833333333333 0.00953079178885631
GO:BP GO:0061458 reproductive system development 0.00346084320546184 432 17 5 0.294117647058824 0.0115740740740741
GO:BP GO:0048608 reproductive structure development 0.00346084320546184 429 17 5 0.294117647058824 0.0116550116550117
GO:BP GO:1901564 organonitrogen compound metabolic process 0.00356146910988186 6792 50 33 0.66 0.00485865724381625
GO:BP GO:0002274 myeloid leukocyte activation 0.00470158059169314 667 48 9 0.1875 0.0134932533733133
GO:BP GO:0044070 regulation of anion transport 0.00500741292822907 896 10 5 0.5 0.00558035714285714
GO:BP GO:0032880 regulation of protein localization 0.00557447136559534 922 10 5 0.5 0.00542299349240781
GO:BP GO:0017038 protein import 0.00587853156089423 205 8 3 0.375 0.0146341463414634
GO:BP GO:0009408 response to heat 0.00587853156089423 159 10 3 0.3 0.0188679245283019
GO:BP GO:0002263 cell activation involved in immune response 0.00693422343376428 721 48 9 0.1875 0.0124826629680999
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00693422343376428 717 48 9 0.1875 0.0125523012552301
GO:BP GO:0006665 sphingolipid metabolic process 0.00693422343376428 169 50 5 0.1 0.029585798816568
GO:BP GO:0006887 exocytosis 0.00693422343376428 904 57 11 0.192982456140351 0.0121681415929204
GO:BP GO:0033365 protein localization to organelle 0.00738606410421156 1017 10 5 0.5 0.00491642084562439
GO:BP GO:0019538 protein metabolic process 0.00861317215492561 5808 50 29 0.58 0.0049931129476584
GO:BP GO:0019058 viral life cycle 0.00861317215492561 353 6 3 0.5 0.0084985835694051
GO:BP GO:0045055 regulated exocytosis 0.00898150108678218 785 57 10 0.175438596491228 0.0127388535031847
GO:BP GO:0010629 negative regulation of gene expression 0.00952144394766902 1460 12 6 0.5 0.00410958904109589
GO:BP GO:0048260 positive regulation of receptor-mediated endocytosis 0.0101966446168594 54 37 3 0.0810810810810811 0.0555555555555556
GO:BP GO:0002181 cytoplasmic translation 0.0104674525627438 103 20 3 0.15 0.029126213592233
GO:BP GO:0006518 peptide metabolic process 0.0107398223048081 955 49 10 0.204081632653061 0.0104712041884817
GO:BP GO:0015031 protein transport 0.0110243859355929 1929 10 6 0.6 0.0031104199066874
GO:BP GO:0009266 response to temperature stimulus 0.0115157680381266 228 10 3 0.3 0.0131578947368421
GO:BP GO:0006886 intracellular protein transport 0.0116295776833131 1186 10 5 0.5 0.00421585160202361
GO:BP GO:0015833 peptide transport 0.0117602701469948 1971 10 6 0.6 0.0030441400304414
GO:BP GO:0008033 tRNA processing 0.0118879527749004 132 79 5 0.0632911392405063 0.0378787878787879
GO:BP GO:0051049 regulation of transport 0.0118879527749004 1809 11 6 0.545454545454545 0.0033167495854063
GO:BP GO:0045184 establishment of protein localization 0.0118879527749004 2035 10 6 0.6 0.00294840294840295
GO:BP GO:0034613 cellular protein localization 0.0118879527749004 2014 10 6 0.6 0.00297914597815293
GO:BP GO:0042886 amide transport 0.0118879527749004 2007 10 6 0.6 0.00298953662182362
GO:BP GO:0006643 membrane lipid metabolic process 0.0118879527749004 217 50 5 0.1 0.0230414746543779
GO:BP GO:0016192 vesicle-mediated transport 0.0118879527749004 2180 49 15 0.306122448979592 0.00688073394495413
GO:BP GO:0070727 cellular macromolecule localization 0.0118879527749004 2024 10 6 0.6 0.00296442687747036
GO:BP GO:0034504 protein localization to nucleus 0.0118879527749004 289 10 3 0.3 0.0103806228373702
GO:BP GO:0033157 regulation of intracellular protein transport 0.0118879527749004 264 10 3 0.3 0.0113636363636364
GO:BP GO:0002443 leukocyte mediated immunity 0.0118879527749004 877 48 9 0.1875 0.0102622576966933
GO:BP GO:0043010 camera-type eye development 0.0118879527749004 331 8 3 0.375 0.00906344410876133
GO:BP GO:0006457 protein folding 0.0118879527749004 225 48 5 0.104166666666667 0.0222222222222222
GO:BP GO:0043269 regulation of ion transport 0.0122604205689263 1379 10 5 0.5 0.00362581580855693
GO:BP GO:0001654 eye development 0.0123649212069273 379 8 3 0.375 0.0079155672823219
GO:BP GO:0150063 visual system development 0.0123967501031541 383 8 3 0.375 0.00783289817232376
GO:BP GO:0006810 transport 0.0125074860832681 5224 63 31 0.492063492063492 0.00593415007656968
GO:BP GO:0048880 sensory system development 0.0126231579508346 389 8 3 0.375 0.0077120822622108
GO:BP GO:0071705 nitrogen compound transport 0.013988755260296 2322 10 6 0.6 0.00258397932816537
GO:BP GO:0010628 positive regulation of gene expression 0.013988755260296 1160 12 5 0.416666666666667 0.00431034482758621
GO:BP GO:0043484 regulation of RNA splicing 0.0142500992963821 160 44 4 0.0909090909090909 0.025
GO:BP GO:0045454 cell redox homeostasis 0.0142780936610358 58 52 3 0.0576923076923077 0.0517241379310345
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0142784388582578 2255 59 17 0.288135593220339 0.00753880266075388
GO:BP GO:0044237 cellular metabolic process 0.0143477560175011 10871 74 58 0.783783783783784 0.00533529574096219
GO:BP GO:0051222 positive regulation of protein transport 0.0144509415828516 329 10 3 0.3 0.00911854103343465
GO:BP GO:0080135 regulation of cellular response to stress 0.0144509415828516 725 11 4 0.363636363636364 0.00551724137931034
GO:BP GO:0051641 cellular localization 0.0157905099366278 3541 10 7 0.7 0.00197684269980232
GO:BP GO:1904951 positive regulation of establishment of protein localization 0.0157905099366278 345 10 3 0.3 0.00869565217391304
GO:BP GO:0046907 intracellular transport 0.0167599185845278 1767 13 6 0.461538461538462 0.0033955857385399
GO:BP GO:0006913 nucleocytoplasmic transport 0.0167599185845278 354 10 3 0.3 0.00847457627118644
GO:BP GO:0051169 nuclear transport 0.0168102734524427 357 10 3 0.3 0.00840336134453781
GO:BP GO:0010243 response to organonitrogen compound 0.0168102734524427 1085 4 3 0.75 0.00276497695852535
GO:BP GO:0043043 peptide biosynthetic process 0.0168102734524427 790 47 8 0.170212765957447 0.010126582278481
GO:BP GO:0051234 establishment of localization 0.0168102734524427 5372 63 31 0.492063492063492 0.00577066269545793
GO:BP GO:0006807 nitrogen compound metabolic process 0.0168102734524427 10078 50 39 0.78 0.00386981543957134
GO:BP GO:0032386 regulation of intracellular transport 0.0168252466325541 367 10 3 0.3 0.00817438692098093
GO:BP GO:0006396 RNA processing 0.0171221922705924 964 79 12 0.151898734177215 0.012448132780083
GO:BP GO:0051050 positive regulation of transport 0.0172655516917772 923 41 8 0.195121951219512 0.00866738894907909
GO:BP GO:1901698 response to nitrogen compound 0.0181878567872399 1172 4 3 0.75 0.00255972696245734
GO:BP GO:0000041 transition metal ion transport 0.0183324810329254 129 63 4 0.0634920634920635 0.0310077519379845
GO:BP GO:0044267 cellular protein metabolic process 0.018803118673715 5229 60 29 0.483333333333333 0.00554599349780073
GO:BP GO:0045807 positive regulation of endocytosis 0.0192798734823545 101 37 3 0.0810810810810811 0.0297029702970297
GO:BP GO:0006399 tRNA metabolic process 0.0197557938778601 185 79 5 0.0632911392405063 0.027027027027027
GO:BP GO:0051649 establishment of localization in cell 0.0207232813323095 2813 43 15 0.348837209302326 0.0053323853537149
GO:BP GO:0003006 developmental process involved in reproduction 0.0207325718983571 982 17 5 0.294117647058824 0.00509164969450102
GO:BP GO:0046683 response to organophosphorus 0.0207325718983571 137 67 4 0.0597014925373134 0.0291970802919708
GO:BP GO:0048259 regulation of receptor-mediated endocytosis 0.0207325718983571 112 37 3 0.0810810810810811 0.0267857142857143
GO:BP GO:0016331 morphogenesis of embryonic epithelium 0.0207325718983571 151 61 4 0.0655737704918033 0.0264900662251656
GO:BP GO:0045321 leukocyte activation 0.0207325718983571 1332 8 4 0.5 0.003003003003003
GO:BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 0.0207325718983571 361 12 3 0.25 0.00831024930747922
GO:BP GO:0000398 mRNA splicing, via spliceosome 0.0207325718983571 361 12 3 0.25 0.00831024930747922
GO:BP GO:0000375 RNA splicing, via transesterification reactions 0.0207325718983571 364 12 3 0.25 0.00824175824175824
GO:BP GO:0007423 sensory organ development 0.0207325718983571 567 8 3 0.375 0.00529100529100529
GO:BP GO:1903311 regulation of mRNA metabolic process 0.0207325718983571 356 12 3 0.25 0.00842696629213483
GO:BP GO:0043066 negative regulation of apoptotic process 0.0207325718983571 921 11 4 0.363636363636364 0.00434310532030402
GO:BP GO:0008306 associative learning 0.0207325718983571 78 54 3 0.0555555555555556 0.0384615384615385
GO:BP GO:0008104 protein localization 0.0207325718983571 2770 10 6 0.6 0.00216606498194946
GO:BP GO:0071702 organic substance transport 0.0207325718983571 2766 10 6 0.6 0.00216919739696312
GO:BP GO:1903793 positive regulation of anion transport 0.0207325718983571 504 19 4 0.210526315789474 0.00793650793650794
GO:BP GO:0043069 negative regulation of programmed cell death 0.0208779790547567 943 11 4 0.363636363636364 0.00424178154825027
GO:BP GO:0006402 mRNA catabolic process 0.0209059296799294 384 12 3 0.25 0.0078125
GO:BP GO:0009056 catabolic process 0.0213772598955112 2744 77 22 0.285714285714286 0.00801749271137026
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.021667488183735 3241 12 7 0.583333333333333 0.00215982721382289
GO:BP GO:0006414 translational elongation 0.021667488183735 141 68 4 0.0588235294117647 0.0283687943262411
GO:BP GO:0001525 angiogenesis 0.021667488183735 617 8 3 0.375 0.00486223662884927
GO:BP GO:0016071 mRNA metabolic process 0.021667488183735 874 12 4 0.333333333333333 0.0045766590389016
GO:BP GO:0006820 anion transport 0.021667488183735 2889 10 6 0.6 0.00207684319833853
GO:BP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 0.0217543054328461 134 34 3 0.0882352941176471 0.0223880597014925
GO:BP GO:0046173 polyol biosynthetic process 0.0225476119501132 64 72 3 0.0416666666666667 0.046875
GO:BP GO:0002009 morphogenesis of an epithelium 0.0225751865905582 560 44 6 0.136363636363636 0.0107142857142857
GO:BP GO:0048024 regulation of mRNA splicing, via spliceosome 0.0225751865905582 119 39 3 0.0769230769230769 0.0252100840336134
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.0225751865905582 896 12 4 0.333333333333333 0.00446428571428571
GO:BP GO:0048589 developmental growth 0.0228038315700823 649 8 3 0.375 0.00462249614791988
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0231271047978616 2518 15 7 0.466666666666667 0.00277998411437649
GO:BP GO:0009057 macromolecule catabolic process 0.0231271047978616 1468 44 10 0.227272727272727 0.00681198910081744
GO:BP GO:0060562 epithelial tube morphogenesis 0.0231271047978616 329 15 3 0.2 0.00911854103343465
GO:BP GO:0006401 RNA catabolic process 0.0234179993803517 424 12 3 0.25 0.00707547169811321
GO:BP GO:0043687 post-translational protein modification 0.0234179993803517 362 14 3 0.214285714285714 0.00828729281767956
GO:BP GO:0044265 cellular macromolecule catabolic process 0.0234179993803517 1231 44 9 0.204545454545455 0.00731112916328188
GO:BP GO:0001775 cell activation 0.0234179993803517 1495 8 4 0.5 0.00267558528428094
GO:BP GO:0060548 negative regulation of cell death 0.0234179993803517 1038 11 4 0.363636363636364 0.00385356454720617
GO:BP GO:0030162 regulation of proteolysis 0.0234179993803517 752 34 6 0.176470588235294 0.00797872340425532
GO:BP GO:1901575 organic substance catabolic process 0.0234179993803517 2267 77 19 0.246753246753247 0.00838112042346714
GO:BP GO:0071704 organic substance metabolic process 0.0234179993803517 11326 50 41 0.82 0.00361998940490906
GO:BP GO:0043067 regulation of programmed cell death 0.0234782491482138 1582 23 7 0.304347826086957 0.00442477876106195
GO:BP GO:0007612 learning 0.0237891667085029 146 72 4 0.0555555555555556 0.0273972602739726
GO:BP GO:0097190 apoptotic signaling pathway 0.0241591513270158 600 30 5 0.166666666666667 0.00833333333333333
GO:BP GO:0055002 striated muscle cell development 0.0241591513270158 111 46 3 0.0652173913043478 0.027027027027027
GO:BP GO:0006412 translation 0.0245805223243203 764 71 9 0.126760563380282 0.0117801047120419
GO:BP GO:0048514 blood vessel morphogenesis 0.0246861951979723 711 8 3 0.375 0.00421940928270042
GO:BP GO:0008380 RNA splicing 0.0248309351807634 456 12 3 0.25 0.00657894736842105
GO:BP GO:0045861 negative regulation of proteolysis 0.0248309351807634 359 15 3 0.2 0.00835654596100279
GO:BP GO:0009892 negative regulation of metabolic process 0.0249450695237248 3479 12 7 0.583333333333333 0.00201207243460765
GO:BP GO:0009719 response to endogenous stimulus 0.0249450695237248 1683 4 3 0.75 0.0017825311942959
GO:BP GO:0043170 macromolecule metabolic process 0.0249450695237248 9796 50 37 0.74 0.00377705185790118
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0249450695237248 3483 12 7 0.583333333333333 0.00200976169968418
GO:BP GO:0050684 regulation of mRNA processing 0.024950167039793 158 69 4 0.0579710144927536 0.0253164556962025
GO:BP GO:1903827 regulation of cellular protein localization 0.0255341336706677 572 10 3 0.3 0.00524475524475524
GO:BP GO:0051726 regulation of cell cycle 0.0256547662486666 1236 10 4 0.4 0.00323624595469256
GO:BP GO:1901700 response to oxygen-containing compound 0.0258504605478285 1739 4 3 0.75 0.00172512938470385
GO:BP GO:0033036 macromolecule localization 0.0263869418219885 3218 10 6 0.6 0.00186451211932878
GO:BP GO:0051239 regulation of multicellular organismal process 0.0263869418219885 2861 11 6 0.545454545454545 0.00209716882209018
GO:BP GO:0009628 response to abiotic stimulus 0.0263869418219885 1261 10 4 0.4 0.00317208564631245
GO:BP GO:0032879 regulation of localization 0.0264094986893716 2872 11 6 0.545454545454545 0.0020891364902507
GO:BP GO:0012501 programmed cell death 0.0266978235608585 2143 23 8 0.347826086956522 0.00373308446103593
GO:BP GO:2000058 regulation of ubiquitin-dependent protein catabolic process 0.0266978235608585 165 34 3 0.0882352941176471 0.0181818181818182
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0266978235608585 2719 15 7 0.466666666666667 0.00257447591026113
GO:BP GO:0030148 sphingolipid biosynthetic process 0.0267179330177294 112 50 3 0.06 0.0267857142857143
GO:BP GO:0051453 regulation of intracellular pH 0.0268613446519307 89 63 3 0.0476190476190476 0.0337078651685393
GO:BP GO:0051130 positive regulation of cellular component organization 0.0275142996627462 1153 41 8 0.195121951219512 0.00693842150910668
GO:BP GO:0001568 blood vessel development 0.0275939124530898 792 8 3 0.375 0.00378787878787879
GO:BP GO:0009605 response to external stimulus 0.0283639578708376 2944 8 5 0.625 0.00169836956521739
GO:BP GO:0044281 small molecule metabolic process 0.0284222207393235 1921 74 16 0.216216216216216 0.00832899531494014
GO:BP GO:0010941 regulation of cell death 0.0290861914973244 1720 23 7 0.304347826086957 0.00406976744186047
GO:BP GO:0030641 regulation of cellular pH 0.0291031297905992 95 63 3 0.0476190476190476 0.0315789473684211
GO:BP GO:0001944 vasculature development 0.0295096143530751 830 8 3 0.375 0.0036144578313253
GO:BP GO:0031329 regulation of cellular catabolic process 0.0295113459464454 866 44 7 0.159090909090909 0.00808314087759815
GO:BP GO:0006397 mRNA processing 0.0295113459464454 532 12 3 0.25 0.0056390977443609
GO:BP GO:0050801 ion homeostasis 0.0296592976378081 808 72 9 0.125 0.0111386138613861
GO:BP GO:0008152 metabolic process 0.0304876220215599 11827 74 59 0.797297297297297 0.0049885854400947
GO:BP GO:0009893 positive regulation of metabolic process 0.0306863654624053 3783 12 7 0.583333333333333 0.00185038329368226
GO:BP GO:0061136 regulation of proteasomal protein catabolic process 0.0307220794835407 186 34 3 0.0882352941176471 0.0161290322580645
GO:BP GO:0048729 tissue morphogenesis 0.0310867069559289 667 31 5 0.161290322580645 0.00749625187406297
GO:BP GO:0006508 proteolysis 0.0312190903790453 1836 46 11 0.239130434782609 0.00599128540305011
GO:BP GO:0016485 protein processing 0.0312190903790453 235 54 4 0.0740740740740741 0.0170212765957447
GO:BP GO:0019725 cellular homeostasis 0.0312190903790453 981 72 10 0.138888888888889 0.0101936799184506
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.0317599631273269 567 12 3 0.25 0.00529100529100529
GO:BP GO:0008219 cell death 0.0317753104752902 2292 23 8 0.347826086956522 0.00349040139616056
GO:BP GO:0006885 regulation of pH 0.0320900021895357 103 63 3 0.0476190476190476 0.029126213592233
GO:BP GO:0051128 regulation of cellular component organization 0.0323331602630832 2412 41 12 0.292682926829268 0.00497512437810945
GO:BP GO:0009725 response to hormone 0.0333891976495809 921 8 3 0.375 0.00325732899022801
GO:BP GO:1903532 positive regulation of secretion by cell 0.0338447796228238 285 74 5 0.0675675675675676 0.0175438596491228
GO:BP GO:0002252 immune effector process 0.0344609351174573 1309 6 3 0.5 0.00229182582123759
GO:BP GO:0046700 heterocycle catabolic process 0.034526585516106 602 12 3 0.25 0.00498338870431894
GO:BP GO:0035239 tube morphogenesis 0.034537438295382 950 15 4 0.266666666666667 0.00421052631578947
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.0350988527186383 608 12 3 0.25 0.00493421052631579
GO:BP GO:0044238 primary metabolic process 0.0351913550585165 10584 74 54 0.72972972972973 0.00510204081632653
GO:BP GO:0002376 immune system process 0.0351946741092021 3278 8 5 0.625 0.00152532031726663
GO:BP GO:0006811 ion transport 0.0352679414336161 3661 10 6 0.6 0.00163889647637258
GO:BP GO:0048513 animal organ development 0.0353094295181008 3672 10 6 0.6 0.00163398692810458
GO:BP GO:0010468 regulation of gene expression 0.0353094295181008 5196 4 4 1 0.000769822940723634
GO:BP GO:0040007 growth 0.0354663341964422 967 8 3 0.375 0.0031023784901758
GO:BP GO:0014070 response to organic cyclic compound 0.0354663341964422 967 8 3 0.375 0.0031023784901758
GO:BP GO:0051179 localization 0.0355909558697033 6901 65 35 0.538461538461538 0.00507172873496595
GO:BP GO:0019439 aromatic compound catabolic process 0.0356118643925605 623 12 3 0.25 0.00481540930979133
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0367376159335867 6603 12 9 0.75 0.00136301681054066
GO:BP GO:0034470 ncRNA processing 0.0370994170543386 397 79 6 0.0759493670886076 0.0151133501259446
GO:BP GO:0043648 dicarboxylic acid metabolic process 0.0371403180096017 99 74 3 0.0405405405405405 0.0303030303030303
GO:BP GO:0070887 cellular response to chemical stimulus 0.0371407223696316 3393 8 5 0.625 0.00147362216327734
GO:BP GO:1901361 organic cyclic compound catabolic process 0.0375378323614102 651 12 3 0.25 0.00460829493087558
GO:BP GO:0010033 response to organic substance 0.0375378323614102 3412 8 5 0.625 0.00146541617819461
GO:BP GO:0030004 cellular monovalent inorganic cation homeostasis 0.0377322826122582 118 63 3 0.0476190476190476 0.0254237288135593
GO:BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 0.0378767862818699 221 34 3 0.0882352941176471 0.0135746606334842
GO:BP GO:0046467 membrane lipid biosynthetic process 0.0380429157908724 151 50 3 0.06 0.0198675496688742
GO:BP GO:0010564 regulation of cell cycle process 0.0380429157908724 809 10 3 0.3 0.00370828182941904
GO:BP GO:0080134 regulation of response to stress 0.0380429157908724 1443 11 4 0.363636363636364 0.00277200277200277
GO:BP GO:0006766 vitamin metabolic process 0.0382110488013507 131 58 3 0.0517241379310345 0.0229007633587786
GO:BP GO:0052548 regulation of endopeptidase activity 0.0387330128037505 437 34 4 0.117647058823529 0.0091533180778032
GO:BP GO:0070588 calcium ion transmembrane transport 0.0389882617422897 320 72 5 0.0694444444444444 0.015625
GO:BP GO:0032508 DNA duplex unwinding 0.0392608178689769 109 71 3 0.0422535211267606 0.0275229357798165
GO:BP GO:0051047 positive regulation of secretion 0.0393158959840953 314 74 5 0.0675675675675676 0.0159235668789809
GO:BP GO:0030100 regulation of endocytosis 0.0393158959840953 212 37 3 0.0810810810810811 0.0141509433962264
GO:BP GO:0009894 regulation of catabolic process 0.0393158959840953 1033 63 9 0.142857142857143 0.00871248789932236
GO:BP GO:0007163 establishment or maintenance of cell polarity 0.0396748648312512 220 36 3 0.0833333333333333 0.0136363636363636
GO:BP GO:0065008 regulation of biological quality 0.0399668485803657 4131 63 23 0.365079365079365 0.0055676591624304
GO:BP GO:0060341 regulation of cellular localization 0.0400958606336376 851 10 3 0.3 0.00352526439482961
GO:BP GO:0055080 cation homeostasis 0.0400958606336376 750 72 8 0.111111111111111 0.0106666666666667
GO:BP GO:0098655 cation transmembrane transport 0.0411071455591061 914 72 9 0.125 0.00984682713347921
GO:BP GO:1901565 organonitrogen compound catabolic process 0.0412508956362348 1358 41 8 0.195121951219512 0.00589101620029455
GO:BP GO:0022414 reproductive process 0.0412508956362348 1493 17 5 0.294117647058824 0.00334896182183523
GO:BP GO:0043524 negative regulation of neuron apoptotic process 0.0412670055642247 150 54 3 0.0555555555555556 0.02
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0412766837975509 1082 15 4 0.266666666666667 0.00369685767097967
GO:BP GO:0000003 reproduction 0.0412766837975509 1496 17 5 0.294117647058824 0.00334224598930481
GO:BP GO:0043933 protein-containing complex subunit organization 0.0415007654661035 1963 47 11 0.234042553191489 0.00560366785532348
GO:BP GO:0009888 tissue development 0.0415869306034842 2107 44 11 0.25 0.00522069292833412
GO:BP GO:0098771 inorganic ion homeostasis 0.0416598236280622 761 72 8 0.111111111111111 0.0105124835742444
GO:BP GO:0032392 DNA geometric change 0.0419079824215178 116 71 3 0.0422535211267606 0.0258620689655172
GO:BP GO:0033554 cellular response to stress 0.0420316617160464 2111 50 12 0.24 0.00568450971103742
GO:BP GO:0042981 regulation of apoptotic process 0.0420661685139353 1549 11 4 0.363636363636364 0.0025823111684958
GO:BP GO:0052547 regulation of peptidase activity 0.0423224853097382 467 34 4 0.117647058823529 0.00856531049250535
GO:BP GO:0072073 kidney epithelium development 0.0423421046677422 137 61 3 0.0491803278688525 0.0218978102189781
GO:BP GO:0035295 tube development 0.0424252071278537 1146 8 3 0.375 0.00261780104712042
GO:BP GO:0055001 muscle cell development 0.0426964077930894 184 46 3 0.0652173913043478 0.016304347826087
GO:BP GO:0043254 regulation of protein-containing complex assembly 0.0429648366000291 460 19 3 0.157894736842105 0.00652173913043478
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.0431278641815662 253 34 3 0.0882352941176471 0.0118577075098814
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0431848632203695 1445 12 4 0.333333333333333 0.0027681660899654
GO:BP GO:0051129 negative regulation of cellular component organization 0.0439519167109005 759 12 3 0.25 0.00395256916996047
GO:BP GO:1903362 regulation of cellular protein catabolic process 0.0440445130339537 257 34 3 0.0882352941176471 0.0116731517509728
GO:BP GO:0072359 circulatory system development 0.0444240430490509 1194 8 3 0.375 0.00251256281407035
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0444497229022491 1145 60 9 0.15 0.00786026200873362
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0445504816387263 1151 15 4 0.266666666666667 0.00347523892267593
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0447252699819318 1202 8 3 0.375 0.00249584026622296
GO:BP GO:0002064 epithelial cell development 0.045239580219245 218 41 3 0.0731707317073171 0.0137614678899083
GO:BP GO:0044260 cellular macromolecule metabolic process 0.045239580219245 8390 31 21 0.67741935483871 0.00250297973778307
GO:BP GO:0051604 protein maturation 0.045239580219245 306 54 4 0.0740740740740741 0.0130718954248366
GO:BP GO:0043009 chordate embryonic development 0.045239580219245 616 15 3 0.2 0.00487012987012987
GO:BP GO:0009653 anatomical structure morphogenesis 0.045239580219245 2797 4 3 0.75 0.00107257776188774
GO:BP GO:0030163 protein catabolic process 0.0453692415507301 974 37 6 0.162162162162162 0.00616016427104723
GO:BP GO:0098662 inorganic cation transmembrane transport 0.04537233237147 794 72 8 0.111111111111111 0.0100755667506297
GO:BP GO:0060429 epithelium development 0.0455306798239799 1325 44 8 0.181818181818182 0.0060377358490566
GO:BP GO:0010467 gene expression 0.0455306798239799 6179 4 4 1 0.000647353940767114
GO:BP GO:0010466 negative regulation of peptidase activity 0.0455306798239799 267 34 3 0.0882352941176471 0.0112359550561798
GO:BP GO:0019222 regulation of metabolic process 0.0458761563200141 7148 12 9 0.75 0.00125909345271405
GO:BP GO:0009792 embryo development ending in birth or egg hatching 0.0466952568485524 635 15 3 0.2 0.0047244094488189
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 0.0483147242298467 1548 12 4 0.333333333333333 0.00258397932816537
GO:BP GO:0051336 regulation of hydrolase activity 0.0483614325199529 1321 54 9 0.166666666666667 0.00681302043906132
GO:BP GO:0007049 cell cycle 0.0483614325199529 1902 10 4 0.4 0.00210304942166141
GO:BP GO:1901576 organic substance biosynthetic process 0.0483614325199529 6248 74 35 0.472972972972973 0.00560179257362356
GO:BP GO:0031334 positive regulation of protein-containing complex assembly 0.0483614325199529 263 36 3 0.0833333333333333 0.0114068441064639
GO:BP GO:0006805 xenobiotic metabolic process 0.0483614325199529 122 77 3 0.038961038961039 0.0245901639344262
GO:BP GO:0065003 protein-containing complex assembly 0.0485349907270655 1680 36 8 0.222222222222222 0.00476190476190476
GO:BP GO:0099173 postsynapse organization 0.0495195728005234 169 57 3 0.0526315789473684 0.0177514792899408
GO:BP GO:0030001 metal ion transport 0.0497600658512209 514 72 6 0.0833333333333333 0.0116731517509728
GO:BP GO:0007417 central nervous system development 0.0497639775533619 1032 10 3 0.3 0.00290697674418605
GO:CC GO:0070062 extracellular exosome 8.77144405804305e-08 2176 41 21 0.51219512195122 0.00965073529411765
GO:CC GO:0043230 extracellular organelle 8.77144405804305e-08 2263 41 21 0.51219512195122 0.00927971718957137
GO:CC GO:0048770 pigment granule 8.77144405804305e-08 105 10 5 0.5 0.0476190476190476
GO:CC GO:1903561 extracellular vesicle 8.77144405804305e-08 2261 41 21 0.51219512195122 0.00928792569659443
GO:CC GO:0042470 melanosome 8.77144405804305e-08 105 10 5 0.5 0.0476190476190476
GO:CC GO:0005615 extracellular space 1.03434491978832e-07 3594 68 35 0.514705882352941 0.0097384529771842
GO:CC GO:0031982 vesicle 7.26463895968327e-07 4055 42 26 0.619047619047619 0.00641183723797781
GO:CC GO:0005576 extracellular region 7.26463895968327e-07 4567 43 28 0.651162790697674 0.00613093934749288
GO:CC GO:0005737 cytoplasm 1.49819497661491e-06 11911 50 48 0.96 0.00402988833851062
GO:CC GO:0034774 secretory granule lumen 1.37598850725611e-05 320 57 9 0.157894736842105 0.028125
GO:CC GO:0031983 vesicle lumen 1.37598850725611e-05 326 57 9 0.157894736842105 0.0276073619631902
GO:CC GO:0060205 cytoplasmic vesicle lumen 1.37598850725611e-05 324 57 9 0.157894736842105 0.0277777777777778
GO:CC GO:0000323 lytic vacuole 1.37598850725611e-05 712 63 13 0.206349206349206 0.0182584269662921
GO:CC GO:0005764 lysosome 1.37598850725611e-05 712 63 13 0.206349206349206 0.0182584269662921
GO:CC GO:0005775 vacuolar lumen 1.49968980516731e-05 174 54 7 0.12962962962963 0.0402298850574713
GO:CC GO:0043227 membrane-bounded organelle 1.91944992852986e-05 12858 74 68 0.918918918918919 0.0052885363198009
GO:CC GO:0099503 secretory vesicle 2.03011176711802e-05 1020 48 13 0.270833333333333 0.0127450980392157
GO:CC GO:0030141 secretory granule 2.03011176711802e-05 851 48 12 0.25 0.0141010575793184
GO:CC GO:0097708 intracellular vesicle 2.71833044562925e-05 2428 63 23 0.365079365079365 0.00947281713344316
GO:CC GO:0031410 cytoplasmic vesicle 2.71833044562925e-05 2424 63 23 0.365079365079365 0.00948844884488449
GO:CC GO:0012505 endomembrane system 3.02670964629722e-05 4640 63 33 0.523809523809524 0.00711206896551724
GO:CC GO:0005773 vacuole 3.54358797718754e-05 810 63 13 0.206349206349206 0.0160493827160494
GO:CC GO:0005739 mitochondrion 5.19547372926913e-05 1673 79 21 0.265822784810127 0.0125523012552301
GO:CC GO:1904813 ficolin-1-rich granule lumen 8.43328192521376e-05 124 6 3 0.5 0.0241935483870968
GO:CC GO:0043202 lysosomal lumen 0.000123196548419249 97 54 5 0.0925925925925926 0.0515463917525773
GO:CC GO:0043226 organelle 0.000141472848219011 14008 77 72 0.935064935064935 0.00513992004568818
GO:CC GO:0031974 membrane-enclosed lumen 0.000228220446384189 5565 76 40 0.526315789473684 0.00718778077268643
GO:CC GO:0043233 organelle lumen 0.000228220446384189 5565 76 40 0.526315789473684 0.00718778077268643
GO:CC GO:0101002 ficolin-1-rich granule 0.000228220446384189 184 6 3 0.5 0.016304347826087
GO:CC GO:0005759 mitochondrial matrix 0.000354106161570246 479 79 10 0.126582278481013 0.0208768267223382
GO:CC GO:0005622 intracellular anatomical structure 0.0007060733909398 14790 50 49 0.98 0.0033130493576741
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.000744912805440557 11296 74 60 0.810810810810811 0.00531161473087819
GO:CC GO:0005925 focal adhesion 0.000765686364501116 420 11 4 0.363636363636364 0.00952380952380952
GO:CC GO:0030055 cell-substrate junction 0.000793173554451342 427 11 4 0.363636363636364 0.00936768149882904
GO:CC GO:1904724 tertiary granule lumen 0.00112732904807866 55 32 3 0.09375 0.0545454545454545
GO:CC GO:1905368 peptidase complex 0.00140941579136144 96 52 4 0.0769230769230769 0.0416666666666667
GO:CC GO:0070013 intracellular organelle lumen 0.00148912914707155 5402 76 37 0.486842105263158 0.00684931506849315
GO:CC GO:0043229 intracellular organelle 0.00156361429783963 12491 74 63 0.851351351351351 0.00504363141461853
GO:CC GO:0005681 spliceosomal complex 0.001888687964638 191 12 3 0.25 0.0157068062827225
GO:CC GO:0150034 distal axon 0.00190887680409247 308 19 4 0.210526315789474 0.012987012987013
GO:CC GO:0030424 axon 0.00212272926959677 660 37 7 0.189189189189189 0.0106060606060606
GO:CC GO:0098852 lytic vacuole membrane 0.00215587053689878 383 7 3 0.428571428571429 0.00783289817232376
GO:CC GO:0005765 lysosomal membrane 0.00215587053689878 383 7 3 0.428571428571429 0.00783289817232376
GO:CC GO:1990904 ribonucleoprotein complex 0.00215587053689878 688 47 8 0.170212765957447 0.0116279069767442
GO:CC GO:0005774 vacuolar membrane 0.00306817929994907 441 7 3 0.428571428571429 0.00680272108843537
GO:CC GO:0035580 specific granule lumen 0.00363518205276424 61 48 3 0.0625 0.0491803278688525
GO:CC GO:0070161 anchoring junction 0.00534180726174624 836 57 9 0.157894736842105 0.0107655502392345
GO:CC GO:0005783 endoplasmic reticulum 0.00534180726174624 1982 77 18 0.233766233766234 0.00908173562058527
GO:CC GO:0000502 proteasome complex 0.00534180726174624 66 52 3 0.0576923076923077 0.0454545454545455
GO:CC GO:0005743 mitochondrial inner membrane 0.00536692175752393 503 58 7 0.120689655172414 0.0139165009940358
GO:CC GO:0031090 organelle membrane 0.00551438147147317 3612 63 23 0.365079365079365 0.00636766334440753
GO:CC GO:0042995 cell projection 0.0057077084090565 2330 11 6 0.545454545454545 0.00257510729613734
GO:CC GO:1905369 endopeptidase complex 0.00625921964520947 72 52 3 0.0576923076923077 0.0416666666666667
GO:CC GO:0005788 endoplasmic reticulum lumen 0.00763623426727669 307 14 3 0.214285714285714 0.00977198697068404
GO:CC GO:0043195 terminal bouton 0.00763623426727669 57 72 3 0.0416666666666667 0.0526315789473684
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.008184353578707 779 13 4 0.307692307692308 0.00513478818998716
GO:CC GO:0098588 bounding membrane of organelle 0.00842514877556039 2158 9 5 0.555555555555556 0.00231696014828545
GO:CC GO:0019866 organelle inner membrane 0.00842514877556039 564 58 7 0.120689655172414 0.0124113475177305
GO:CC GO:0012506 vesicle membrane 0.0085362816332234 800 13 4 0.307692307692308 0.005
GO:CC GO:0120025 plasma membrane bounded cell projection 0.0111750581564342 2229 6 4 0.666666666666667 0.00179452669358457
GO:CC GO:0070820 tertiary granule 0.0118139808487582 163 32 3 0.09375 0.0184049079754601
GO:CC GO:0005740 mitochondrial envelope 0.0124351468152904 797 58 8 0.137931034482759 0.0100376411543287
GO:CC GO:0030662 coated vesicle membrane 0.0126764556744662 177 31 3 0.0967741935483871 0.0169491525423729
GO:CC GO:0030054 cell junction 0.0133828516159764 2105 57 14 0.245614035087719 0.00665083135391924
GO:CC GO:0098793 presynapse 0.0133891802442054 521 37 5 0.135135135135135 0.00959692898272553
GO:CC GO:0005902 microvillus 0.0140988226738504 91 63 3 0.0476190476190476 0.032967032967033
GO:CC GO:0005768 endosome 0.0158030870608334 987 7 3 0.428571428571429 0.00303951367781155
GO:CC GO:0043005 neuron projection 0.0158030870608334 1380 10 4 0.4 0.00289855072463768
GO:CC GO:0031975 envelope 0.0165088525090834 1237 59 10 0.169491525423729 0.00808407437348424
GO:CC GO:0031967 organelle envelope 0.0165088525090834 1237 59 10 0.169491525423729 0.00808407437348424
GO:CC GO:0098590 plasma membrane region 0.0170309097371027 1240 6 3 0.5 0.00241935483870968
GO:CC GO:0140513 nuclear protein-containing complex 0.0179085269966697 1249 69 11 0.159420289855072 0.00880704563650921
GO:CC GO:0005796 Golgi lumen 0.0223082151312355 99 76 3 0.0394736842105263 0.0303030303030303
GO:CC GO:0031966 mitochondrial membrane 0.0223082151312355 746 58 7 0.120689655172414 0.00938337801608579
GO:CC GO:0042581 specific granule 0.0223082151312355 158 48 3 0.0625 0.0189873417721519
GO:CC GO:0016020 membrane 0.0229709765763636 9838 72 48 0.666666666666667 0.00487904045537711
GO:CC GO:0044391 ribosomal subunit 0.0309988173515014 190 47 3 0.0638297872340425 0.0157894736842105
GO:CC GO:0030135 coated vesicle 0.0319377424214094 295 31 3 0.0967741935483871 0.0101694915254237
GO:CC GO:1902494 catalytic complex 0.032457163406135 1441 34 7 0.205882352941176 0.00485773768216516
GO:CC GO:0035770 ribonucleoprotein granule 0.0346593483376388 248 71 4 0.0563380281690141 0.0161290322580645
GO:CC GO:0045202 synapse 0.034668774780262 1349 37 7 0.189189189189189 0.00518902891030393
GO:CC GO:0001726 ruffle 0.0461558175204738 179 63 3 0.0476190476190476 0.0167597765363128
GO:CC GO:0005840 ribosome 0.0472914065279514 245 47 3 0.0638297872340425 0.0122448979591837
GO:MF GO:0023026 MHC class II protein complex binding 4.24662058994829e-08 17 10 4 0.4 0.235294117647059
GO:MF GO:0023023 MHC protein complex binding 1.12624601784175e-07 25 10 4 0.4 0.16
GO:MF GO:0045296 cadherin binding 1.89589998094089e-06 333 11 6 0.545454545454545 0.018018018018018
GO:MF GO:0050839 cell adhesion molecule binding 2.67569636648997e-05 546 11 6 0.545454545454545 0.010989010989011
GO:MF GO:0003723 RNA binding 0.00463757528078217 1943 12 7 0.583333333333333 0.0036026762738034
GO:MF GO:0051082 unfolded protein binding 0.00889414686437611 112 46 4 0.0869565217391304 0.0357142857142857
GO:MF GO:0003725 double-stranded RNA binding 0.010103266456845 77 71 4 0.0563380281690141 0.051948051948052
GO:MF GO:0031625 ubiquitin protein ligase binding 0.0122811200849778 296 10 3 0.3 0.0101351351351351
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.0124199144861246 314 10 3 0.3 0.00955414012738853
GO:MF GO:0044877 protein-containing complex binding 0.0152278650923712 1287 12 5 0.416666666666667 0.00388500388500389
GO:MF GO:0044325 ion channel binding 0.0152278650923712 135 57 4 0.0701754385964912 0.0296296296296296
GO:MF GO:0016835 carbon-oxygen lyase activity 0.0167701863353987 81 50 3 0.06 0.037037037037037
GO:MF GO:0008237 metallopeptidase activity 0.0167701863353987 188 46 4 0.0869565217391304 0.0212765957446809
GO:MF GO:0004175 endopeptidase activity 0.018466612729883 450 54 6 0.111111111111111 0.0133333333333333
GO:MF GO:0005524 ATP binding 0.0194386958870112 1501 74 14 0.189189189189189 0.00932711525649567
GO:MF GO:0004222 metalloendopeptidase activity 0.0214450721419177 108 46 3 0.0652173913043478 0.0277777777777778
GO:MF GO:0008233 peptidase activity 0.0216757328742084 646 54 7 0.12962962962963 0.0108359133126935
GO:MF GO:0003729 mRNA binding 0.0216757328742084 552 20 4 0.2 0.0072463768115942
GO:MF GO:0032559 adenyl ribonucleotide binding 0.0235371036286381 1565 74 14 0.189189189189189 0.00894568690095847
GO:MF GO:0030554 adenyl nucleotide binding 0.0244377502121545 1578 74 14 0.189189189189189 0.00887198986058302
GO:MF GO:0036094 small molecule binding 0.0247293882706658 2506 74 19 0.256756756756757 0.00758180367118915
GO:MF GO:0097367 carbohydrate derivative binding 0.0274016837734979 2285 76 18 0.236842105263158 0.00787746170678337
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 0.0328467356117058 1847 74 15 0.202702702702703 0.00812127774769897
GO:MF GO:0043168 anion binding 0.0328801421708017 2418 74 18 0.243243243243243 0.00744416873449132
GO:MF GO:0008135 translation factor activity, RNA binding 0.0329454267037208 99 68 3 0.0441176470588235 0.0303030303030303
GO:MF GO:0042802 identical protein binding 0.0364340196700887 2067 12 5 0.416666666666667 0.00241896468311563
GO:MF GO:0019904 protein domain specific binding 0.0364340196700887 710 11 3 0.272727272727273 0.00422535211267606
GO:MF GO:0032555 purine ribonucleotide binding 0.0364340196700887 1918 74 15 0.202702702702703 0.00782064650677789
GO:MF GO:0032553 ribonucleotide binding 0.0369436176927243 1935 74 15 0.202702702702703 0.00775193798449612
GO:MF GO:0017076 purine nucleotide binding 0.0369436176927243 1933 74 15 0.202702702702703 0.00775995861355406
GO:MF GO:0003676 nucleic acid binding 0.0375718940102242 4276 12 7 0.583333333333333 0.00163704396632367
GO:MF GO:0000166 nucleotide binding 0.0406797068259074 2171 74 16 0.216216216216216 0.00736987563334869
GO:MF GO:1901265 nucleoside phosphate binding 0.0406797068259074 2172 74 16 0.216216216216216 0.00736648250460405
GO:MF GO:0090079 translation regulator activity, nucleic acid binding 0.0413257495373021 123 68 3 0.0441176470588235 0.024390243902439
GO:MF GO:0030674 protein-macromolecule adaptor activity 0.0494593617850632 266 36 3 0.0833333333333333 0.0112781954887218
HPA HPA:0080122 caudate; glial cells[≥Medium] 0.00477338689180822 2230 52 24 0.461538461538462 0.010762331838565
HPA HPA:0570801 testis; sertoli cells[≥Low] 0.00477338689180822 2256 48 23 0.479166666666667 0.0101950354609929
HPA HPA:0430053 seminal vesicle; glandular cells[High] 0.00477338689180822 1410 74 24 0.324324324324324 0.0170212765957447
HPA HPA:0250122 hippocampus; glial cells[≥Medium] 0.00720302536452942 1926 52 21 0.403846153846154 0.0109034267912773
HPA HPA:0570802 testis; sertoli cells[≥Medium] 0.00720302536452942 1662 43 17 0.395348837209302 0.0102286401925391
HPA HPA:0351183 pancreas; pancreatic endocrine cells[High] 0.00720302536452942 758 71 15 0.211267605633803 0.0197889182058048
HPA HPA:0570803 testis; sertoli cells[High] 0.00720302536452942 536 48 10 0.208333333333333 0.0186567164179104
HPA HPA:0530722 spleen; cells in white pulp[≥Medium] 0.00890926107616693 2645 46 23 0.5 0.00869565217391304
HPA HPA:0210053 fallopian tube; glandular cells[High] 0.00962042804456841 1728 13 8 0.615384615384615 0.00462962962962963
HPA HPA:0210853 fallopian tube; ciliated cells (cell body)[High] 0.00962042804456841 104 63 5 0.0793650793650794 0.0480769230769231
HPA HPA:0250121 hippocampus; glial cells[≥Low] 0.00962042804456841 4033 52 32 0.615384615384615 0.00793454004463179
HPA HPA:0080123 caudate; glial cells[High] 0.00962042804456841 628 39 9 0.230769230769231 0.0143312101910828
HPA HPA:0100122 cerebral cortex; glial cells[≥Medium] 0.00962042804456841 2588 51 24 0.470588235294118 0.00927357032457496
HPA HPA:0170053 endometrium 2; glandular cells[High] 0.00962042804456841 1282 74 20 0.27027027027027 0.015600624024961
HPA HPA:0310433 lymph node; germinal center cells[High] 0.00962042804456841 908 13 6 0.461538461538462 0.0066079295154185
HPA HPA:0420053 salivary gland; glandular cells[High] 0.00962042804456841 1418 73 21 0.287671232876712 0.0148095909732017
HPA HPA:0600223 tonsil; squamous epithelial cells[High] 0.0118885469041631 1442 74 21 0.283783783783784 0.0145631067961165
HPA HPA:0291162 liver; cholangiocytes[≥Medium] 0.0118885469041631 1910 25 12 0.48 0.00628272251308901
HPA HPA:0550053 stomach 2; glandular cells[High] 0.0118885469041631 2350 74 29 0.391891891891892 0.0123404255319149
HPA HPA:0380513 placenta; decidual cells[High] 0.0158570605852272 1144 12 6 0.5 0.00524475524475524
HPA HPA:0610833 urinary bladder; urothelial cells[High] 0.0161265561056508 1969 73 25 0.342465753424658 0.0126968004062976
HPA HPA:0080133 caudate; neuronal cells[High] 0.0161265561056508 1059 13 6 0.461538461538462 0.0056657223796034
HPA HPA:0020053 adrenal gland; glandular cells[High] 0.0185511429258669 2199 74 27 0.364864864864865 0.0122783083219645
HPA HPA:0160052 endometrium 1; glandular cells[≥Medium] 0.0203852182979428 5014 74 48 0.648648648648649 0.00957319505384922
HPA HPA:0530723 spleen; cells in white pulp[High] 0.0206164528167737 811 12 5 0.416666666666667 0.0061652281134402
HPA HPA:0250133 hippocampus; neuronal cells[High] 0.0277608593890409 1210 13 6 0.461538461538462 0.00495867768595041
HPA HPA:0190223 esophagus; squamous epithelial cells[High] 0.0295757968487162 1596 74 21 0.283783783783784 0.0131578947368421
HPA HPA:0100121 cerebral cortex; glial cells[≥Low] 0.0299378879295886 4804 52 34 0.653846153846154 0.0070774354704413
HPA HPA:0390053 prostate; glandular cells[High] 0.0305210621152857 1284 74 18 0.243243243243243 0.014018691588785
HPA HPA:0250123 hippocampus; glial cells[High] 0.0316001223499065 508 74 10 0.135135135135135 0.0196850393700787
HPA HPA:0380523 placenta; trophoblastic cells[High] 0.0331959738646096 1998 15 8 0.533333333333333 0.004004004004004
HPA HPA:0350473 pancreas; exocrine glandular cells[High] 0.0365543539737038 1879 74 23 0.310810810810811 0.0122405534858968
HPA HPA:0540053 stomach 1; glandular cells[High] 0.0368791913466565 2365 74 27 0.364864864864865 0.0114164904862579
HPA HPA:0291163 liver; cholangiocytes[High] 0.0368791913466565 294 37 5 0.135135135135135 0.0170068027210884
MIRNA MIRNA:hsa-miR-4698 hsa-miR-4698 0.0130373646454935 216 45 6 0.133333333333333 0.0277777777777778
MIRNA MIRNA:hsa-miR-1238-5p hsa-miR-1238-5p 0.0130373646454935 66 16 3 0.1875 0.0454545454545455
MIRNA MIRNA:hsa-miR-484 hsa-miR-484 0.0130373646454935 890 20 7 0.35 0.00786516853932584
MIRNA MIRNA:hsa-miR-615-3p hsa-miR-615-3p 0.0130373646454935 891 20 7 0.35 0.00785634118967452
MIRNA MIRNA:hsa-miR-15b-5p hsa-miR-15b-5p 0.0130373646454935 760 37 10 0.27027027027027 0.0131578947368421
MIRNA MIRNA:hsa-miR-877-3p hsa-miR-877-3p 0.0130373646454935 602 12 5 0.416666666666667 0.00830564784053156
MIRNA MIRNA:hsa-miR-328-3p hsa-miR-328-3p 0.0130373646454935 132 11 3 0.272727272727273 0.0227272727272727
MIRNA MIRNA:hsa-miR-4272 hsa-miR-4272 0.0130373646454935 87 16 3 0.1875 0.0344827586206897
MIRNA MIRNA:hsa-miR-16-5p hsa-miR-16-5p 0.0155885405821432 1556 63 17 0.26984126984127 0.0109254498714653
MIRNA MIRNA:hsa-miR-4533 hsa-miR-4533 0.0173221138718807 229 59 6 0.101694915254237 0.0262008733624454
MIRNA MIRNA:hsa-miR-92a-3p hsa-miR-92a-3p 0.0173221138718807 1404 30 10 0.333333333333333 0.00712250712250712
MIRNA MIRNA:hsa-miR-33a-3p hsa-miR-33a-3p 0.0173221138718807 145 13 3 0.230769230769231 0.0206896551724138
MIRNA MIRNA:hsa-miR-5196-5p hsa-miR-5196-5p 0.0173221138718807 303 44 6 0.136363636363636 0.0198019801980198
MIRNA MIRNA:hsa-miR-4747-5p hsa-miR-4747-5p 0.0173221138718807 303 44 6 0.136363636363636 0.0198019801980198
MIRNA MIRNA:hsa-miR-320a hsa-miR-320a 0.0212195709239539 584 10 4 0.4 0.00684931506849315
MIRNA MIRNA:hsa-miR-3133 hsa-miR-3133 0.0212195709239539 187 12 3 0.25 0.0160427807486631
MIRNA MIRNA:hsa-miR-935 hsa-miR-935 0.02524218712134 120 20 3 0.15 0.025
MIRNA MIRNA:hsa-miR-326 hsa-miR-326 0.0254292954103642 136 42 4 0.0952380952380952 0.0294117647058824
MIRNA MIRNA:hsa-miR-6758-5p hsa-miR-6758-5p 0.0254292954103642 259 10 3 0.3 0.0115830115830116
MIRNA MIRNA:hsa-miR-6778-5p hsa-miR-6778-5p 0.0292906252127995 191 14 3 0.214285714285714 0.0157068062827225
MIRNA MIRNA:hsa-miR-1233-5p hsa-miR-1233-5p 0.0295390590482563 196 14 3 0.214285714285714 0.0153061224489796
MIRNA MIRNA:hsa-miR-340-5p hsa-miR-340-5p 0.0309872569643054 340 9 3 0.333333333333333 0.00882352941176471
MIRNA MIRNA:hsa-miR-361-5p hsa-miR-361-5p 0.0478578049871427 160 48 4 0.0833333333333333 0.025
REAC REAC:R-HSA-3371556 Cellular response to heat stress 0.0054229524279267 87 10 3 0.3 0.0344827586206897
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.0127302903562496 474 48 9 0.1875 0.0189873417721519
REAC REAC:R-HSA-72172 mRNA Splicing 0.0276340399892833 186 12 3 0.25 0.0161290322580645
REAC REAC:R-HSA-428157 Sphingolipid metabolism 0.0276340399892833 86 23 3 0.130434782608696 0.0348837209302326
REAC REAC:R-HSA-597592 Post-translational protein modification 0.0276340399892833 1377 14 7 0.5 0.00508351488743646
REAC REAC:R-HSA-72163 mRNA Splicing - Major Pathway 0.0276340399892833 178 12 3 0.25 0.0168539325842697
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.028378935319489 546 10 4 0.4 0.00732600732600733
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.0292554208944744 560 10 4 0.4 0.00714285714285714
REAC REAC:R-HSA-392499 Metabolism of proteins 0.0313058506285421 1961 14 8 0.571428571428571 0.00407955124936257
REAC REAC:R-HSA-9675108 Nervous system development 0.0357103932346125 574 6 3 0.5 0.00522648083623693
REAC REAC:R-HSA-1643685 Disease 0.0357103932346125 1509 3 3 1 0.00198807157057654
REAC REAC:R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.0357103932346125 235 12 3 0.25 0.0127659574468085
REAC REAC:R-HSA-422475 Axon guidance 0.0357103932346125 549 6 3 0.5 0.00546448087431694
REAC REAC:R-HSA-8953854 Metabolism of RNA 0.0480668909009998 658 12 4 0.333333333333333 0.0060790273556231
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.00307602253628323 13022 74 67 0.905405405405405 0.005145138995546
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.00307602253628323 14473 76 72 0.947368421052632 0.00497478062599323
TF TF:M02011 Factor: HES-1; motif: GSCACGMGMC 0.00326042767275458 4259 72 33 0.458333333333333 0.00774829772247006
TF TF:M02044 Factor: YY1; motif: GCCGCCATTTTG 0.00326042767275458 6102 45 29 0.644444444444444 0.00475254015077024
TF TF:M11052 Factor: Hey2; motif: NNCACGYGNN 0.00326042767275458 12502 64 57 0.890625 0.00455927051671732
TF TF:M12183 Factor: KLF14; motif: NRCCACRCCCMCN 0.00326042767275458 6878 76 46 0.605263157894737 0.00668799069496947
TF TF:M08266_1 Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 0.00326042767275458 8979 75 54 0.72 0.00601403274306716
TF TF:M10581 Factor: Barhl2; motif: NTAAACGGT 0.0034411943478315 1359 80 18 0.225 0.0132450331125828
TF TF:M08982 Factor: YY1; motif: NAANATGGCGNNN 0.0034411943478315 7125 43 30 0.697674418604651 0.00421052631578947
TF TF:M11066 Factor: HES-7; motif: GNCACGYGNN 0.0034411943478315 11507 64 54 0.84375 0.00469279568958026
TF TF:M00982 Factor: KROX; motif: CCCGCCCCCRCCCC 0.00406240728393368 7815 76 49 0.644736842105263 0.00626999360204734
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.00446860440768346 10765 72 57 0.791666666666667 0.00529493729679517
TF TF:M11061 Factor: HES-1; motif: GGCRCGTGNC 0.0055760969308463 6271 78 43 0.551282051282051 0.00685696061234253
TF TF:M08225_1 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 0.00596764677410726 7993 72 47 0.652777777777778 0.00588014512698611
TF TF:M02281 Factor: SP1; motif: CCCCKCCCCC 0.00865092364380912 6480 75 42 0.56 0.00648148148148148
TF TF:M11987_1 Factor: NFATc3; motif: NAYGGAAANW; match class: 1 0.00905392017264596 199 62 6 0.0967741935483871 0.0301507537688442
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.00905392017264596 6260 66 37 0.560606060606061 0.00591054313099042
TF TF:M09641 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN 0.00905392017264596 3222 76 27 0.355263157894737 0.00837988826815642
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.00905392017264596 10640 74 57 0.77027027027027 0.00535714285714286
TF TF:M11066_1 Factor: HES-7; motif: GNCACGYGNN; match class: 1 0.00937464140140577 8172 76 49 0.644736842105263 0.00599608418991679
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.00937464140140577 4320 20 13 0.65 0.00300925925925926
TF TF:M07617 Factor: Sp4; motif: SCCCCKCCCCCSN 0.0119072740089138 3595 74 28 0.378378378378378 0.00778859527121001
TF TF:M09971 Factor: GKLF; motif: WGGGYGKGGC 0.0125205161825972 5546 64 33 0.515625 0.00595023440317346
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.0125205161825972 14873 74 69 0.932432432432432 0.00463927923082095
TF TF:M02064 Factor: c-ets-2; motif: ACCGGAWRTN 0.0125916100716534 10939 72 56 0.777777777777778 0.00511929792485602
TF TF:M11981 Factor: NFATc1; motif: NTTTCCRTNNAYGGAAAN 0.0125916100716534 6351 44 27 0.613636363636364 0.00425129900803023
TF TF:M00986 Factor: Churchill; motif: CGGGNN 0.0140686626738837 14197 80 72 0.9 0.0050714939776009
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.0142170488786706 7283 64 39 0.609375 0.00535493615268433
TF TF:M12152 Factor: Sp1; motif: NWRGCCACGCCCMCN 0.0168661300663989 7341 64 39 0.609375 0.00531262770739681
TF TF:M01243 Factor: MTF-1; motif: TGCGCAC 0.0181098525906015 2835 54 19 0.351851851851852 0.00670194003527337
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.0182601532364457 9715 75 53 0.706666666666667 0.00545548121461657
TF TF:M04110 Factor: RUNX3; motif: NRACCGCANWAACCRCAN 0.0182601532364457 9266 19 17 0.894736842105263 0.00183466436434276
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.0182601532364457 8944 64 44 0.6875 0.00491949910554562
TF TF:M11058 Factor: Hey1; motif: NGCRCGYGYN 0.0182601532364457 13162 64 56 0.875 0.00425467254216684
TF TF:M04064_1 Factor: Pax-5; motif: NGTCACGCWTSANTGMNY; match class: 1 0.0182601532364457 3538 67 25 0.373134328358209 0.00706613906161673
TF TF:M11981_1 Factor: NFATc1; motif: NTTTCCRTNNAYGGAAAN; match class: 1 0.0182601532364457 5744 44 25 0.568181818181818 0.00435236768802228
TF TF:M11052_1 Factor: Hey2; motif: NNCACGYGNN; match class: 1 0.0182601532364457 9523 76 53 0.697368421052632 0.00556547306521054
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.0182601532364457 14106 76 68 0.894736842105263 0.00482064369771728
TF TF:M04287 Factor: BARHL2; motif: NNTAAAYGNN 0.0182601532364457 4416 80 33 0.4125 0.00747282608695652
TF TF:M12151 Factor: Sp1; motif: NWRGCCMCGCCCMCN 0.0182601532364457 6821 64 37 0.578125 0.00542442457117725
TF TF:M07397 Factor: ZBP89; motif: CCCCKCCCCCNN 0.0184300812419197 7143 77 44 0.571428571428571 0.00615987680246395
TF TF:M11533 Factor: E2F-1; motif: NTTTTGGCGCCAWWWN 0.0232915185993509 13105 75 64 0.853333333333333 0.00488363220144983
TF TF:M01597 Factor: Zfp281; motif: TGGGGGAGGGG 0.0240781575018406 1016 25 7 0.28 0.00688976377952756
TF TF:M07226 Factor: SP1; motif: NCCCCKCCCCC 0.0242121948146439 8292 67 43 0.641791044776119 0.00518572117703811
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0242121948146439 13611 77 67 0.87012987012987 0.00492248916317684
TF TF:M01182 Factor: MIZF; motif: CGGACGTT 0.0242435723291236 241 70 6 0.0857142857142857 0.024896265560166
TF TF:M08226_1 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG; match class: 1 0.0245731352087246 5604 72 35 0.486111111111111 0.00624553890078515
TF TF:M10785_1 Factor: hoxa9; motif: RTCGTWANNN; match class: 1 0.0248009224190992 1160 62 12 0.193548387096774 0.0103448275862069
TF TF:M00109 Factor: C/EBPbeta; motif: RNRTKDNGMAAKNN 0.0252150937482435 3254 39 16 0.41025641025641 0.00491702519975415
TF TF:M11081_1 Factor: SREBP-1; motif: RTCRCGTGAY; match class: 1 0.0252150937482435 7890 76 46 0.605263157894737 0.00583016476552598
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0256543410208618 13929 76 67 0.881578947368421 0.00481010840692081
TF TF:M12153 Factor: Sp3; motif: NGCCACGCCCMCN 0.0262371728537098 6205 64 34 0.53125 0.00547945205479452
TF TF:M11986 Factor: NFATc2; motif: NTTTCCATNNATGGAAAN 0.028751338823863 6055 44 25 0.568181818181818 0.00412881915772089
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.02905095987814 13173 74 63 0.851351351351351 0.00478250967888864
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.02905095987814 16228 76 73 0.960526315789474 0.00449839783090954
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.02905095987814 6334 61 33 0.540983606557377 0.00520997789706347
TF TF:M04515 Factor: E2F-1; motif: WWTGGCGCCAAA 0.02905095987814 13334 76 65 0.855263157894737 0.00487475626218689
TF TF:M06689 Factor: ZNF319; motif: NTMTWAAGGCTC 0.0298553431970099 107 25 3 0.12 0.0280373831775701
TF TF:M00322 Factor: c-Myc:Max; motif: GCCAYGYGSN 0.0301023657564945 7873 79 47 0.594936708860759 0.00596977010034294
TF TF:M08226 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG 0.030162459494951 12039 75 60 0.8 0.0049838026414154
TF TF:M11529 Factor: E2F-2; motif: GCGCGCGCNCS 0.030162459494951 16263 76 73 0.960526315789474 0.00448871671893255
TF TF:M01104 Factor: MOVO-B; motif: GNGGGGG 0.030162459494951 10261 80 57 0.7125 0.0055550141311763
TF TF:M11077 Factor: TCFL5; motif: KCACGCGCMC 0.0322936647441416 990 76 12 0.157894736842105 0.0121212121212121
TF TF:M04953 Factor: Sp1; motif: GGNDGGRGGCGGGG 0.0323272475230406 8688 75 48 0.64 0.00552486187845304
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.0323272475230406 8492 67 43 0.641791044776119 0.00506358926048045
TF TF:M11427 Factor: PEA3; motif: NACCGGAAGTN 0.0326066509745043 10585 72 53 0.736111111111111 0.00500708549834672
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.0326066509745043 7801 76 45 0.592105263157895 0.00576849121907448
TF TF:M11986_1 Factor: NFATc2; motif: NTTTCCATNNATGGAAAN; match class: 1 0.0330865018239467 5796 44 24 0.545454545454545 0.0041407867494824
TF TF:M11078 Factor: TCFL5; motif: KCACGCGCNC 0.0333869696865143 1471 76 15 0.197368421052632 0.0101971447994562
TF TF:M11530_1 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 0.033608024721622 13449 76 65 0.855263157894737 0.00483307309093613
TF TF:M09642_1 Factor: p53; motif: RGRCATGTCTGGRCATGYCN; match class: 1 0.033608024721622 246 29 4 0.137931034482759 0.016260162601626
TF TF:M09834 Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN 0.033608024721622 6953 75 41 0.546666666666667 0.00589673522220624
TF TF:M02028 Factor: Pbx1; motif: ATCAATCAN 0.0343527821256739 1304 17 6 0.352941176470588 0.00460122699386503
TF TF:M01857 Factor: AP-2alpha; motif: NGCCYSNNGSN 0.0343527821256739 9178 74 49 0.662162162162162 0.00533885378078013
TF TF:M10119 Factor: REX-1; motif: GGCMGCCATTTT 0.0343527821256739 1888 43 12 0.27906976744186 0.00635593220338983
TF TF:M03924_1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 0.0343527821256739 3700 51 20 0.392156862745098 0.00540540540540541
TF TF:M00987 Factor: FOXP1; motif: TTATTTGTRTTKKYTWKTWT 0.0343527821256739 280 27 4 0.148148148148148 0.0142857142857143
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 0.0343527821256739 12351 74 60 0.810810810810811 0.00485790624240952
TF TF:M00933_1 Factor: Sp1; motif: CCCCGCCCCN; match class: 1 0.0343527821256739 5166 63 29 0.46031746031746 0.00561362756484708
TF TF:M03895 Factor: CTCF; motif: WGCGCCMYCTAGYGGYN 0.0343527821256739 9251 77 51 0.662337662337662 0.00551291752243001
TF TF:M11081 Factor: SREBP-1; motif: RTCRCGTGAY 0.0343527821256739 11062 79 59 0.746835443037975 0.00533357439884289
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.0343527821256739 10357 77 55 0.714285714285714 0.00531041807473207
TF TF:M11979 Factor: NFATc1; motif: NTTTCCRTNNAYGGAAAN 0.0343527821256739 8844 44 31 0.704545454545455 0.0035052012663953
TF TF:M08377 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN 0.0343527821256739 11275 72 55 0.763888888888889 0.0048780487804878
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0343527821256739 10233 52 39 0.75 0.00381119906185869
TF TF:M10112_1 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 0.0343527821256739 4075 25 13 0.52 0.00319018404907975
TF TF:M12086 Factor: ZNF501; motif: NNGCGACGCGAACAN 0.0351343693894487 1830 57 14 0.245614035087719 0.00765027322404372
TF TF:M00144 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM 0.035166663707913 13205 76 64 0.842105263157895 0.0048466489965922
TF TF:M09723 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS 0.0364564705169843 10156 67 48 0.716417910447761 0.00472627018511225
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.0364564705169843 10494 67 49 0.73134328358209 0.0046693348580141
TF TF:M01145 Factor: c-Myc; motif: RACCACGTGCTC 0.0364564705169843 6248 76 38 0.5 0.00608194622279129
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.0364564705169843 15268 76 70 0.921052631578947 0.00458475242336914
TF TF:M11446 Factor: Elf-1; motif: RANSMGGAAGTR 0.0364564705169843 2915 64 20 0.3125 0.00686106346483705
TF TF:M04287_1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 1 0.0364564705169843 713 30 6 0.2 0.00841514726507714
TF TF:M11018_1 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 0.0364564705169843 15920 74 70 0.945945945945946 0.00439698492462312
TF TF:M11430 Factor: PEA3; motif: NACCGGAAGTN 0.0364564705169843 10865 76 56 0.736842105263158 0.00515416474919466
TF TF:M11733 Factor: PXR; motif: NYGAACTSNNTGAACTC 0.0364564705169843 2983 15 8 0.533333333333333 0.00268186389540731
TF TF:M08767_1 Factor: HES-1; motif: GNCACGTGNC; match class: 1 0.0365072990418996 7709 76 44 0.578947368421053 0.00570761447658581
TF TF:M08266 Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG 0.0365072990418996 14377 23 23 1 0.00159977742227168
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 0.0365072990418996 14575 76 68 0.894736842105263 0.00466552315608919
TF TF:M12183_1 Factor: KLF14; motif: NRCCACRCCCMCN; match class: 1 0.0365072990418996 2487 69 19 0.27536231884058 0.00763972657820667
TF TF:M04694 Factor: NRF-1; motif: CNCTGCGCATGCGC 0.0365072990418996 1548 68 14 0.205882352941176 0.00904392764857881
TF TF:M09761 Factor: EGR1; motif: NGNGKGGGYGGNGS 0.0365072990418996 5162 61 28 0.459016393442623 0.00542425416505231
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.0365336589941501 14593 76 68 0.894736842105263 0.00465976838210101
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.0365336589941501 8495 74 46 0.621621621621622 0.00541494997057092
TF TF:M12188 Factor: KLF17; motif: NGMCMCRCCCTN 0.037026830545622 3673 79 27 0.341772151898734 0.00735093928668663
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0372874671810815 7696 66 39 0.590909090909091 0.00506756756756757
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0372874671810815 7696 66 39 0.590909090909091 0.00506756756756757
TF TF:M11061_1 Factor: HES-1; motif: GGCRCGTGNC; match class: 1 0.0382321140395871 2453 76 20 0.263157894736842 0.00815328169588259
TF TF:M11303_1 Factor: batf3; motif: GRTGACGTCATC; match class: 1 0.039605562197163 584 38 6 0.157894736842105 0.0102739726027397
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.0399294269156107 11232 76 57 0.75 0.00507478632478632
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.0402093485979666 16103 67 64 0.955223880597015 0.00397441470533441
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.040747227736505 8031 76 45 0.592105263157895 0.00560328726186029
TF TF:M00428_1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 0.040880283589639 3615 73 25 0.342465753424658 0.00691562932226833
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.0419141693547394 7469 66 38 0.575757575757576 0.00508769580934529
TF TF:M04744_1 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 0.0424062280476849 4889 53 24 0.452830188679245 0.00490897934137861
TF TF:M00225_1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 0.0429970167014879 1922 70 16 0.228571428571429 0.00832466181061394
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0429970167014879 10281 64 46 0.71875 0.00447427293064877
TF TF:M02281_1 Factor: SP1; motif: CCCCKCCCCC; match class: 1 0.0429970167014879 2558 69 19 0.27536231884058 0.00742767787333855
TF TF:M11058_1 Factor: Hey1; motif: NGCRCGYGYN; match class: 1 0.0429970167014879 10925 64 48 0.75 0.00439359267734554
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0429970167014879 9106 76 49 0.644736842105263 0.0053810674280694
TF TF:M08767 Factor: HES-1; motif: GNCACGTGNC 0.0429970167014879 7813 76 44 0.578947368421053 0.0056316395750672
TF TF:M09882 Factor: C/EBPdelta; motif: NTTGCNCMAYN 0.0429970167014879 2027 32 10 0.3125 0.00493339911198816
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.0429970167014879 10230 74 52 0.702702702702703 0.0050830889540567
TF TF:M10880_1 Factor: Alx-4; motif: NNCRTTAN; match class: 1 0.0429970167014879 2683 21 9 0.428571428571429 0.0033544539694372
TF TF:M11387 Factor: elf5; motif: NNNNMGGAAGTN 0.0429970167014879 2598 63 18 0.285714285714286 0.0069284064665127
TF TF:M11979_1 Factor: NFATc1; motif: NTTTCCRTNNAYGGAAAN; match class: 1 0.0442176037768258 8680 44 30 0.681818181818182 0.00345622119815668
TF TF:M11303 Factor: batf3; motif: GRTGACGTCATC 0.0444824137637047 614 38 6 0.157894736842105 0.00977198697068404
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0453037612729819 8415 64 40 0.625 0.0047534165181224
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0461602500765025 13270 74 62 0.837837837837838 0.00467219291635268
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.0464560436931855 11728 48 39 0.8125 0.00332537517053206
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.0474890105221721 7508 15 12 0.8 0.00159829515183804
TF TF:M10112 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR 0.0480613543416183 8711 25 19 0.76 0.00218115026977385
TF TF:M01273 Factor: SP4; motif: SCCCCGCCCCS 0.0480613543416183 3296 64 21 0.328125 0.00637135922330097
TF TF:M11385_1 Factor: ESE-1; motif: NTGTGCGGATGCN; match class: 1 0.0480613543416183 5491 79 35 0.443037974683544 0.00637406665452559
TF TF:M08870_1 Factor: DEC1; motif: NCNCACRTGNSC; match class: 1 0.0480613543416183 2440 79 20 0.253164556962025 0.00819672131147541
TF TF:M03793 Factor: IRF-7; motif: AARGGAAANNGAA 0.0480613543416183 1987 63 15 0.238095238095238 0.00754906894816306
TF TF:M04201_1 Factor: CEBPB; motif: ATTRCGCAAY; match class: 1 0.0480613543416183 1501 66 13 0.196969696969697 0.00866089273817455
TF TF:M04059 Factor: NRF-1; motif: YGCGCATGCGCN 0.0480613543416183 1471 59 12 0.203389830508475 0.00815771583956492
TF TF:M00665_1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 1 0.0480613543416183 2293 72 18 0.25 0.00784997819450502
TF TF:M07208 Factor: EGR1; motif: NCNCCGCCCCCGCN 0.0480613543416183 6183 61 31 0.508196721311475 0.00501374737182597
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.0480613543416183 10253 76 53 0.697368421052632 0.00516921876523944
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.0489375089248148 15260 72 66 0.916666666666667 0.00432503276539974

pEpi23 transcription factor target enrichment of top program genes

TF enrichment of pEpi23
Possible regulators of activation of pEpi23 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.