pM03 program activity among Myeloid cells

Activation of pM03
pM03 gene program activation in Myeloid cells.
Gene program activation of pM03 by different cell subtypes
pM03 gene program activation among cells of different subtypes (Myeloid cells).

pM03 top program genes

Top genes of pM03 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pM03 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pM03
pM03 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006735 NADH regeneration 1.55464415588434e-20 27 64 12 0.1875 0.444444444444444
GO:BP GO:0019674 NAD metabolic process 1.55464415588434e-20 52 64 14 0.21875 0.269230769230769
GO:BP GO:0061718 glucose catabolic process to pyruvate 1.55464415588434e-20 27 64 12 0.1875 0.444444444444444
GO:BP GO:0061621 canonical glycolysis 1.55464415588434e-20 27 64 12 0.1875 0.444444444444444
GO:BP GO:0061620 glycolytic process through glucose-6-phosphate 2.17072840745741e-20 28 64 12 0.1875 0.428571428571429
GO:BP GO:0061615 glycolytic process through fructose-6-phosphate 3.07765358435288e-20 29 64 12 0.1875 0.413793103448276
GO:BP GO:0006007 glucose catabolic process 6.24533699288665e-19 36 64 12 0.1875 0.333333333333333
GO:BP GO:0006734 NADH metabolic process 1.6542402499242e-17 46 64 12 0.1875 0.260869565217391
GO:BP GO:0009179 purine ribonucleoside diphosphate metabolic process 1.99880225740035e-16 136 50 14 0.28 0.102941176470588
GO:BP GO:0009135 purine nucleoside diphosphate metabolic process 1.99880225740035e-16 136 50 14 0.28 0.102941176470588
GO:BP GO:0019320 hexose catabolic process 2.12384475867754e-16 57 64 12 0.1875 0.210526315789474
GO:BP GO:0009185 ribonucleoside diphosphate metabolic process 2.28314130738791e-16 139 50 14 0.28 0.100719424460432
GO:BP GO:0046365 monosaccharide catabolic process 6.67272190915962e-16 63 64 12 0.1875 0.19047619047619
GO:BP GO:0006090 pyruvate metabolic process 7.57590675371011e-16 151 64 15 0.234375 0.0993377483443709
GO:BP GO:0046031 ADP metabolic process 1.05456048983873e-15 123 48 13 0.270833333333333 0.105691056910569
GO:BP GO:0009132 nucleoside diphosphate metabolic process 1.08041842046788e-15 158 50 14 0.28 0.0886075949367089
GO:BP GO:0006165 nucleoside diphosphate phosphorylation 2.93682005528669e-15 134 48 13 0.270833333333333 0.0970149253731343
GO:BP GO:0046939 nucleotide phosphorylation 3.06367962579566e-15 135 48 13 0.270833333333333 0.0962962962962963
GO:BP GO:0006096 glycolytic process 1.62278582392615e-14 115 34 11 0.323529411764706 0.0956521739130435
GO:BP GO:0006757 ATP generation from ADP 1.70116029209559e-14 116 34 11 0.323529411764706 0.0948275862068965
GO:BP GO:0001666 response to hypoxia 2.51014154278506e-13 367 92 20 0.217391304347826 0.0544959128065395
GO:BP GO:0036293 response to decreased oxygen levels 5.14601841665978e-13 382 92 20 0.217391304347826 0.0523560209424084
GO:BP GO:0070482 response to oxygen levels 1.71697185885883e-12 408 92 20 0.217391304347826 0.0490196078431373
GO:BP GO:0016052 carbohydrate catabolic process 5.55067105672272e-12 198 34 11 0.323529411764706 0.0555555555555556
GO:BP GO:0009150 purine ribonucleotide metabolic process 5.55067105672272e-12 414 64 17 0.265625 0.0410628019323672
GO:BP GO:0009259 ribonucleotide metabolic process 1.02739870415249e-11 431 64 17 0.265625 0.0394431554524362
GO:BP GO:0019693 ribose phosphate metabolic process 1.43553689771946e-11 441 64 17 0.265625 0.0385487528344671
GO:BP GO:0006163 purine nucleotide metabolic process 1.920175839309e-11 450 64 17 0.265625 0.0377777777777778
GO:BP GO:0006091 generation of precursor metabolites and energy 2.79460096776484e-11 538 48 16 0.333333333333333 0.0297397769516729
GO:BP GO:0006006 glucose metabolic process 3.83205848530648e-11 211 64 13 0.203125 0.0616113744075829
GO:BP GO:0072521 purine-containing compound metabolic process 3.87869178933599e-11 473 64 17 0.265625 0.0359408033826638
GO:BP GO:0005996 monosaccharide metabolic process 5.82356962762813e-11 276 64 14 0.21875 0.0507246376811594
GO:BP GO:0046034 ATP metabolic process 9.94314316488888e-11 314 48 13 0.270833333333333 0.0414012738853503
GO:BP GO:0009117 nucleotide metabolic process 3.29403077777161e-10 544 64 17 0.265625 0.03125
GO:BP GO:0006094 gluconeogenesis 3.29403077777161e-10 89 34 8 0.235294117647059 0.0898876404494382
GO:BP GO:0019318 hexose metabolic process 3.29403077777161e-10 253 64 13 0.203125 0.0513833992094862
GO:BP GO:0006753 nucleoside phosphate metabolic process 4.09711953945746e-10 555 64 17 0.265625 0.0306306306306306
GO:BP GO:0019319 hexose biosynthetic process 4.09711953945746e-10 92 34 8 0.235294117647059 0.0869565217391304
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 4.61743596553974e-10 629 66 18 0.272727272727273 0.0286168521462639
GO:BP GO:0046364 monosaccharide biosynthetic process 6.53005037775446e-10 98 34 8 0.235294117647059 0.0816326530612245
GO:BP GO:0016051 carbohydrate biosynthetic process 1.09488042333822e-09 214 66 12 0.181818181818182 0.0560747663551402
GO:BP GO:0019752 carboxylic acid metabolic process 2.80046295140105e-09 1024 66 21 0.318181818181818 0.0205078125
GO:BP GO:0046903 secretion 3.78044678438435e-09 1501 89 29 0.325842696629214 0.0193204530313125
GO:BP GO:0044282 small molecule catabolic process 4.77330220460488e-09 439 48 13 0.270833333333333 0.0296127562642369
GO:BP GO:0032787 monocarboxylic acid metabolic process 4.77330220460488e-09 658 64 17 0.265625 0.0258358662613982
GO:BP GO:0043436 oxoacid metabolic process 4.77330220460488e-09 1057 66 21 0.318181818181818 0.0198675496688742
GO:BP GO:0005975 carbohydrate metabolic process 4.77330220460488e-09 635 66 17 0.257575757575758 0.0267716535433071
GO:BP GO:0006082 organic acid metabolic process 7.81169395381681e-09 1090 66 21 0.318181818181818 0.0192660550458716
GO:BP GO:0044281 small molecule metabolic process 9.66991104543998e-09 1921 66 27 0.409090909090909 0.0140551795939615
GO:BP GO:0032940 secretion by cell 1.08064109754985e-08 1364 89 27 0.303370786516854 0.0197947214076246
GO:BP GO:0044283 small molecule biosynthetic process 2.12375855124971e-08 704 66 17 0.257575757575758 0.0241477272727273
GO:BP GO:0140352 export from cell 2.47257960604122e-08 1418 89 27 0.303370786516854 0.0190409026798307
GO:BP GO:0002274 myeloid leukocyte activation 2.48556450013748e-08 667 89 19 0.213483146067416 0.0284857571214393
GO:BP GO:0071456 cellular response to hypoxia 4.20507508155756e-08 212 92 12 0.130434782608696 0.0566037735849057
GO:BP GO:0043299 leukocyte degranulation 4.35989149467e-08 535 89 17 0.191011235955056 0.0317757009345794
GO:BP GO:0002444 myeloid leukocyte mediated immunity 6.6954806028915e-08 551 89 17 0.191011235955056 0.0308529945553539
GO:BP GO:0036294 cellular response to decreased oxygen levels 6.74481705413856e-08 222 92 12 0.130434782608696 0.0540540540540541
GO:BP GO:0019637 organophosphate metabolic process 6.7724306959737e-08 1041 70 20 0.285714285714286 0.0192122958693564
GO:BP GO:0042119 neutrophil activation 1.1626242064197e-07 498 89 16 0.179775280898876 0.0321285140562249
GO:BP GO:0036230 granulocyte activation 1.35687459154848e-07 504 89 16 0.179775280898876 0.0317460317460317
GO:BP GO:0071453 cellular response to oxygen levels 1.52653076327832e-07 240 92 12 0.130434782608696 0.05
GO:BP GO:0045055 regulated exocytosis 3.11943248567564e-07 785 89 19 0.213483146067416 0.024203821656051
GO:BP GO:0002275 myeloid cell activation involved in immune response 4.13203973775426e-07 547 89 16 0.179775280898876 0.0292504570383912
GO:BP GO:0002366 leukocyte activation involved in immune response 4.59495235740392e-07 717 89 18 0.202247191011236 0.0251046025104603
GO:BP GO:0002263 cell activation involved in immune response 4.93065059745255e-07 721 89 18 0.202247191011236 0.0249653259361997
GO:BP GO:0006887 exocytosis 4.99370828883263e-07 904 89 20 0.224719101123595 0.0221238938053097
GO:BP GO:0043312 neutrophil degranulation 5.26186613024585e-07 482 89 15 0.168539325842697 0.0311203319502075
GO:BP GO:0002283 neutrophil activation involved in immune response 5.55005429267492e-07 485 89 15 0.168539325842697 0.0309278350515464
GO:BP GO:0006950 response to stress 5.55005429267492e-07 4170 89 45 0.50561797752809 0.0107913669064748
GO:BP GO:1901135 carbohydrate derivative metabolic process 5.95708744178605e-07 1145 66 19 0.287878787878788 0.0165938864628821
GO:BP GO:0002446 neutrophil mediated immunity 7.46577223189131e-07 497 89 15 0.168539325842697 0.0301810865191147
GO:BP GO:0070887 cellular response to chemical stimulus 8.60804074937118e-07 3393 87 39 0.448275862068966 0.0114942528735632
GO:BP GO:0042221 response to chemical 1.60723127346585e-06 4781 87 47 0.540229885057471 0.00983057937669943
GO:BP GO:0010273 detoxification of copper ion 3.89477021677258e-06 14 59 4 0.0677966101694915 0.285714285714286
GO:BP GO:1990169 stress response to copper ion 3.89477021677258e-06 14 59 4 0.0677966101694915 0.285714285714286
GO:BP GO:0061687 detoxification of inorganic compound 6.86401763165285e-06 16 59 4 0.0677966101694915 0.25
GO:BP GO:0097501 stress response to metal ion 6.86401763165285e-06 16 59 4 0.0677966101694915 0.25
GO:BP GO:0009628 response to abiotic stimulus 9.00316062361775e-06 1261 92 22 0.239130434782609 0.0174464710547185
GO:BP GO:0002252 immune effector process 9.06514521217203e-06 1309 89 22 0.247191011235955 0.0168067226890756
GO:BP GO:0008219 cell death 1.05392842270866e-05 2292 39 18 0.461538461538462 0.00785340314136126
GO:BP GO:0012501 programmed cell death 2.32000194626135e-05 2143 39 17 0.435897435897436 0.00793280447970135
GO:BP GO:1901575 organic substance catabolic process 2.93370320961148e-05 2267 34 16 0.470588235294118 0.0070577856197618
GO:BP GO:0071294 cellular response to zinc ion 3.04593432169372e-05 23 59 4 0.0677966101694915 0.173913043478261
GO:BP GO:0002443 leukocyte mediated immunity 3.7500722491316e-05 877 89 17 0.191011235955056 0.0193842645381984
GO:BP GO:0006915 apoptotic process 4.66098613273467e-05 1990 39 16 0.41025641025641 0.00804020100502513
GO:BP GO:0045321 leukocyte activation 4.71845212742891e-05 1332 89 21 0.235955056179775 0.0157657657657658
GO:BP GO:0046688 response to copper ion 5.07527750110958e-05 42 85 5 0.0588235294117647 0.119047619047619
GO:BP GO:0071280 cellular response to copper ion 5.63876903567753e-05 27 59 4 0.0677966101694915 0.148148148148148
GO:BP GO:0046686 response to cadmium ion 7.25857092865093e-05 65 59 5 0.0847457627118644 0.0769230769230769
GO:BP GO:0001775 cell activation 7.49399690737627e-05 1495 89 22 0.247191011235955 0.0147157190635452
GO:BP GO:0016192 vesicle-mediated transport 0.000108326713781786 2180 89 27 0.303370786516854 0.0123853211009174
GO:BP GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia 0.000138543452632926 7 92 3 0.0326086956521739 0.428571428571429
GO:BP GO:0072522 purine-containing compound biosynthetic process 0.000141691018500708 213 57 7 0.12280701754386 0.0328638497652582
GO:BP GO:0050896 response to stimulus 0.000152528458519212 9407 89 67 0.752808988764045 0.00712235569256936
GO:BP GO:0030388 fructose 1,6-bisphosphate metabolic process 0.000152528458519212 10 64 3 0.046875 0.3
GO:BP GO:0010043 response to zinc ion 0.000177462447614146 55 85 5 0.0588235294117647 0.0909090909090909
GO:BP GO:0071276 cellular response to cadmium ion 0.000184097688195111 37 59 4 0.0677966101694915 0.108108108108108
GO:BP GO:0006882 cellular zinc ion homeostasis 0.000184097688195111 37 59 4 0.0677966101694915 0.108108108108108
GO:BP GO:0010941 regulation of cell death 0.000203437484632936 1720 39 14 0.358974358974359 0.00813953488372093
GO:BP GO:0018126 protein hydroxylation 0.000203437484632936 28 81 4 0.0493827160493827 0.142857142857143
GO:BP GO:0035795 negative regulation of mitochondrial membrane permeability 0.000203437484632936 8 92 3 0.0326086956521739 0.375
GO:BP GO:0016310 phosphorylation 0.000218786392879736 2138 64 21 0.328125 0.009822263797942
GO:BP GO:0055069 zinc ion homeostasis 0.000218786392879736 39 59 4 0.0677966101694915 0.102564102564103
GO:BP GO:0045765 regulation of angiogenesis 0.000233054299213515 358 87 10 0.114942528735632 0.0279329608938547
GO:BP GO:0009056 catabolic process 0.000238289505392886 2744 48 20 0.416666666666667 0.00728862973760933
GO:BP GO:0010038 response to metal ion 0.000250979492191713 371 85 10 0.117647058823529 0.0269541778975741
GO:BP GO:0051156 glucose 6-phosphate metabolic process 0.000250979492191713 25 30 3 0.1 0.12
GO:BP GO:1901342 regulation of vasculature development 0.000259523338503337 364 87 10 0.114942528735632 0.0274725274725275
GO:BP GO:0042981 regulation of apoptotic process 0.000324978801526331 1549 39 13 0.333333333333333 0.00839251129761136
GO:BP GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline 0.000367681386030708 11 81 3 0.037037037037037 0.272727272727273
GO:BP GO:0006754 ATP biosynthetic process 0.000386484917642041 59 46 4 0.0869565217391304 0.0677966101694915
GO:BP GO:0010035 response to inorganic substance 0.000386484917642041 575 85 12 0.141176470588235 0.0208695652173913
GO:BP GO:0008637 apoptotic mitochondrial changes 0.000386484917642041 126 22 4 0.181818181818182 0.0317460317460317
GO:BP GO:0043067 regulation of programmed cell death 0.000390416025879509 1582 39 13 0.333333333333333 0.00821744627054362
GO:BP GO:0002376 immune system process 0.000440602269667896 3278 89 33 0.370786516853933 0.0100671140939597
GO:BP GO:0000422 autophagy of mitochondrion 0.000498726951882246 75 39 4 0.102564102564103 0.0533333333333333
GO:BP GO:0061726 mitochondrion disassembly 0.000498726951882246 75 39 4 0.102564102564103 0.0533333333333333
GO:BP GO:1905709 negative regulation of membrane permeability 0.000502958038313372 11 92 3 0.0326086956521739 0.272727272727273
GO:BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process 0.000718765701788512 70 46 4 0.0869565217391304 0.0571428571428571
GO:BP GO:0048878 chemical homeostasis 0.000718765701788512 1229 82 17 0.207317073170732 0.0138323840520749
GO:BP GO:0006810 transport 0.000731217551953165 5224 89 44 0.49438202247191 0.00842266462480858
GO:BP GO:0006898 receptor-mediated endocytosis 0.000731217551953165 333 87 9 0.103448275862069 0.027027027027027
GO:BP GO:1904018 positive regulation of vasculature development 0.000731217551953165 187 87 7 0.0804597701149425 0.0374331550802139
GO:BP GO:0009145 purine nucleoside triphosphate biosynthetic process 0.000731217551953165 71 46 4 0.0869565217391304 0.0563380281690141
GO:BP GO:0009605 response to external stimulus 0.000731217551953165 2944 45 19 0.422222222222222 0.00645380434782609
GO:BP GO:0045766 positive regulation of angiogenesis 0.000731217551953165 187 87 7 0.0804597701149425 0.0374331550802139
GO:BP GO:0002576 platelet degranulation 0.000731217551953165 126 87 6 0.0689655172413793 0.0476190476190476
GO:BP GO:1903146 regulation of autophagy of mitochondrion 0.000881339247836285 31 39 3 0.0769230769230769 0.0967741935483871
GO:BP GO:0006164 purine nucleotide biosynthetic process 0.000887096573197863 202 57 6 0.105263157894737 0.0297029702970297
GO:BP GO:0009201 ribonucleoside triphosphate biosynthetic process 0.000891477187696174 76 46 4 0.0869565217391304 0.0526315789473684
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.000924267121332585 497 92 11 0.119565217391304 0.0221327967806841
GO:BP GO:0019511 peptidyl-proline hydroxylation 0.000987660209650601 16 81 3 0.037037037037037 0.1875
GO:BP GO:0016241 regulation of macroautophagy 0.0012533678725719 161 47 5 0.106382978723404 0.031055900621118
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.00126478547930883 516 92 11 0.119565217391304 0.0213178294573643
GO:BP GO:0009205 purine ribonucleoside triphosphate metabolic process 0.00126478547930883 84 46 4 0.0869565217391304 0.0476190476190476
GO:BP GO:0097190 apoptotic signaling pathway 0.00126657015949381 600 22 6 0.272727272727273 0.01
GO:BP GO:0051234 establishment of localization 0.0013712016728041 5372 89 44 0.49438202247191 0.00819061801935964
GO:BP GO:0009142 nucleoside triphosphate biosynthetic process 0.00142075947415019 87 46 4 0.0869565217391304 0.0459770114942529
GO:BP GO:0046902 regulation of mitochondrial membrane permeability 0.00155219925439932 80 19 3 0.157894736842105 0.0375
GO:BP GO:0009144 purine nucleoside triphosphate metabolic process 0.00159969203096426 90 46 4 0.0869565217391304 0.0444444444444444
GO:BP GO:1903008 organelle disassembly 0.00161781399371042 107 39 4 0.102564102564103 0.0373831775700935
GO:BP GO:0009199 ribonucleoside triphosphate metabolic process 0.00164757656046785 91 46 4 0.0869565217391304 0.043956043956044
GO:BP GO:0006955 immune response 0.00172856062457556 2311 89 25 0.280898876404494 0.0108178277801817
GO:BP GO:0070997 neuron death 0.00172942171970775 365 37 6 0.162162162162162 0.0164383561643836
GO:BP GO:0019725 cellular homeostasis 0.00188231111049865 981 36 9 0.25 0.00917431192660551
GO:BP GO:0044262 cellular carbohydrate metabolic process 0.00191722240126191 296 66 7 0.106060606060606 0.0236486486486486
GO:BP GO:0042592 homeostatic process 0.0020841680329834 1981 92 23 0.25 0.0116102978293791
GO:BP GO:0065008 regulation of biological quality 0.00209905044255971 4131 88 36 0.409090909090909 0.00871459694989107
GO:BP GO:0030595 leukocyte chemotaxis 0.00209905044255971 227 87 7 0.0804597701149425 0.0308370044052863
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.00225400993129957 1042 87 15 0.172413793103448 0.0143953934740883
GO:BP GO:0060326 cell chemotaxis 0.00226734538464813 310 87 8 0.0919540229885057 0.0258064516129032
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.00235596786295279 3087 66 24 0.363636363636364 0.00777453838678328
GO:BP GO:0090559 regulation of membrane permeability 0.00235596786295279 95 19 3 0.157894736842105 0.0315789473684211
GO:BP GO:0051402 neuron apoptotic process 0.00264361287153485 250 58 6 0.103448275862069 0.024
GO:BP GO:0006793 phosphorus metabolic process 0.00267462380502275 3114 66 24 0.363636363636364 0.00770712909441233
GO:BP GO:0010033 response to organic substance 0.00289430944638555 3412 87 31 0.35632183908046 0.00908558030480656
GO:BP GO:1901564 organonitrogen compound metabolic process 0.00300527046652641 6792 22 17 0.772727272727273 0.00250294464075383
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 0.0030354781063377 294 18 4 0.222222222222222 0.0136054421768707
GO:BP GO:0010243 response to organonitrogen compound 0.0030354781063377 1085 51 11 0.215686274509804 0.0101382488479263
GO:BP GO:0001525 angiogenesis 0.0030354781063377 617 87 11 0.126436781609195 0.0178282009724473
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0030354781063377 1001 23 7 0.304347826086957 0.00699300699300699
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.0030354781063377 686 66 10 0.151515151515152 0.0145772594752187
GO:BP GO:0009167 purine ribonucleoside monophosphate metabolic process 0.00311691269467742 40 50 3 0.06 0.075
GO:BP GO:0009141 nucleoside triphosphate metabolic process 0.00326012921350018 113 46 4 0.0869565217391304 0.0353982300884956
GO:BP GO:0050878 regulation of body fluid levels 0.00326047508678939 514 88 10 0.113636363636364 0.0194552529182879
GO:BP GO:0009165 nucleotide biosynthetic process 0.00328384210137191 269 57 6 0.105263157894737 0.0223048327137546
GO:BP GO:0055082 cellular chemical homeostasis 0.00331660720165867 841 36 8 0.222222222222222 0.00951248513674197
GO:BP GO:0031639 plasminogen activation 0.00333313663419347 24 87 3 0.0344827586206897 0.125
GO:BP GO:0071248 cellular response to metal ion 0.00335914173871455 192 28 4 0.142857142857143 0.0208333333333333
GO:BP GO:0006875 cellular metal ion homeostasis 0.00335914173871455 593 92 11 0.119565217391304 0.0185497470489039
GO:BP GO:1901293 nucleoside phosphate biosynthetic process 0.00343852940543469 273 57 6 0.105263157894737 0.021978021978022
GO:BP GO:0043066 negative regulation of apoptotic process 0.00351550874215756 921 92 14 0.152173913043478 0.0152008686210641
GO:BP GO:0060548 negative regulation of cell death 0.0035297646978069 1038 92 15 0.16304347826087 0.0144508670520231
GO:BP GO:0009126 purine nucleoside monophosphate metabolic process 0.00361825531945835 43 50 3 0.06 0.0697674418604651
GO:BP GO:1903578 regulation of ATP metabolic process 0.00371834754040125 119 46 4 0.0869565217391304 0.0336134453781513
GO:BP GO:0009152 purine ribonucleotide biosynthetic process 0.00389848235169259 179 57 5 0.087719298245614 0.0279329608938547
GO:BP GO:0043069 negative regulation of programmed cell death 0.00428882372932734 943 92 14 0.152173913043478 0.0148462354188759
GO:BP GO:0016239 positive regulation of macroautophagy 0.0044747560174898 60 39 3 0.0769230769230769 0.05
GO:BP GO:0043030 regulation of macrophage activation 0.00450016248934426 65 89 4 0.0449438202247191 0.0615384615384615
GO:BP GO:2000108 positive regulation of leukocyte apoptotic process 0.00458170692495492 29 82 3 0.0365853658536585 0.103448275862069
GO:BP GO:1900371 regulation of purine nucleotide biosynthetic process 0.00472140439972887 42 57 3 0.0526315789473684 0.0714285714285714
GO:BP GO:0030808 regulation of nucleotide biosynthetic process 0.00493696772295064 43 57 3 0.0526315789473684 0.0697674418604651
GO:BP GO:0009260 ribonucleotide biosynthetic process 0.00500988113045888 192 57 5 0.087719298245614 0.0260416666666667
GO:BP GO:1901698 response to nitrogen compound 0.00502585298359361 1172 51 11 0.215686274509804 0.00938566552901024
GO:BP GO:0071241 cellular response to inorganic substance 0.00502904305645593 220 28 4 0.142857142857143 0.0181818181818182
GO:BP GO:0070613 regulation of protein processing 0.00512371121685538 66 92 4 0.0434782608695652 0.0606060606060606
GO:BP GO:0010821 regulation of mitochondrion organization 0.0052184501527937 158 39 4 0.102564102564103 0.0253164556962025
GO:BP GO:0048284 organelle fusion 0.00538084053758437 148 42 4 0.0952380952380952 0.027027027027027
GO:BP GO:1903317 regulation of protein maturation 0.00563399972052468 68 92 4 0.0434782608695652 0.0588235294117647
GO:BP GO:0046390 ribose phosphate biosynthetic process 0.00567694736647627 199 57 5 0.087719298245614 0.0251256281407035
GO:BP GO:2000378 negative regulation of reactive oxygen species metabolic process 0.00617799889024695 69 39 3 0.0769230769230769 0.0434782608695652
GO:BP GO:0098771 inorganic ion homeostasis 0.00641964168281984 761 92 12 0.130434782608696 0.0157687253613666
GO:BP GO:0090407 organophosphate biosynthetic process 0.00654836108272584 598 70 9 0.128571428571429 0.0150501672240803
GO:BP GO:0009161 ribonucleoside monophosphate metabolic process 0.00678216445215039 56 50 3 0.06 0.0535714285714286
GO:BP GO:0007006 mitochondrial membrane organization 0.00680569091465368 151 19 3 0.157894736842105 0.0198675496688742
GO:BP GO:0051707 response to other organism 0.00698627669848105 1592 23 8 0.347826086956522 0.0050251256281407
GO:BP GO:0043207 response to external biotic stimulus 0.0070135685265414 1594 23 8 0.347826086956522 0.00501882057716437
GO:BP GO:1900542 regulation of purine nucleotide metabolic process 0.00712737172898525 119 57 4 0.0701754385964912 0.0336134453781513
GO:BP GO:0055065 metal ion homeostasis 0.00734476615470865 667 92 11 0.119565217391304 0.0164917541229385
GO:BP GO:0046916 cellular transition metal ion homeostasis 0.00734476615470865 116 59 4 0.0677966101694915 0.0344827586206897
GO:BP GO:0006140 regulation of nucleotide metabolic process 0.0074881394992349 121 57 4 0.0701754385964912 0.0330578512396694
GO:BP GO:0098542 defense response to other organism 0.00753302845230653 1218 23 7 0.304347826086957 0.00574712643678161
GO:BP GO:0033554 cellular response to stress 0.0075848857662827 2111 27 10 0.37037037037037 0.00473709142586452
GO:BP GO:0048514 blood vessel morphogenesis 0.0075848857662827 711 87 11 0.126436781609195 0.0154711673699015
GO:BP GO:0009607 response to biotic stimulus 0.00766930303083339 1626 23 8 0.347826086956522 0.00492004920049201
GO:BP GO:0030003 cellular cation homeostasis 0.00770444861244891 673 92 11 0.119565217391304 0.0163447251114413
GO:BP GO:0045926 negative regulation of growth 0.00771081661834798 255 28 4 0.142857142857143 0.0156862745098039
GO:BP GO:0046128 purine ribonucleoside metabolic process 0.00847610129947664 62 50 3 0.06 0.0483870967741935
GO:BP GO:0097529 myeloid leukocyte migration 0.00864408467753385 221 87 6 0.0689655172413793 0.0271493212669683
GO:BP GO:0006873 cellular ion homeostasis 0.00892557494895461 687 92 11 0.119565217391304 0.0160116448326055
GO:BP GO:0050900 leukocyte migration 0.00935599004782707 511 87 9 0.103448275862069 0.0176125244618395
GO:BP GO:0042278 purine nucleoside metabolic process 0.00935599004782707 65 50 3 0.06 0.0461538461538462
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.00944598148835606 2255 18 8 0.444444444444444 0.00354767184035477
GO:BP GO:0050801 ion homeostasis 0.00944598148835606 808 92 12 0.130434782608696 0.0148514851485149
GO:BP GO:0043467 regulation of generation of precursor metabolites and energy 0.00945236494309989 164 46 4 0.0869565217391304 0.024390243902439
GO:BP GO:0010822 positive regulation of mitochondrion organization 0.00995622470152896 86 39 3 0.0769230769230769 0.0348837209302326
GO:BP GO:1901652 response to peptide 0.00999098828567362 551 51 7 0.137254901960784 0.0127041742286751
GO:BP GO:0016032 viral process 0.0107467415234045 942 23 6 0.260869565217391 0.00636942675159236
GO:BP GO:0051604 protein maturation 0.0109721373659066 306 92 7 0.0760869565217391 0.0228758169934641
GO:BP GO:0098754 detoxification 0.0110314026547527 134 59 4 0.0677966101694915 0.0298507462686567
GO:BP GO:0051641 cellular localization 0.0110347792905411 3541 92 31 0.33695652173913 0.00875458909912454
GO:BP GO:0007589 body fluid secretion 0.0111243622794504 90 88 4 0.0454545454545455 0.0444444444444444
GO:BP GO:0016236 macroautophagy 0.0113056116497258 312 12 3 0.25 0.00961538461538462
GO:BP GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 0.01186082270459 91 89 4 0.0449438202247191 0.043956043956044
GO:BP GO:0055076 transition metal ion homeostasis 0.011884689968267 138 59 4 0.0677966101694915 0.0289855072463768
GO:BP GO:0034637 cellular carbohydrate biosynthetic process 0.01222477288895 90 91 4 0.043956043956044 0.0444444444444444
GO:BP GO:0048519 negative regulation of biological process 0.0125684830861289 5757 19 13 0.684210526315789 0.00225812054889699
GO:BP GO:0006935 chemotaxis 0.0125684830861289 653 87 10 0.114942528735632 0.0153139356814701
GO:BP GO:0006952 defense response 0.0126496406096933 1818 89 19 0.213483146067416 0.0104510451045105
GO:BP GO:0009119 ribonucleoside metabolic process 0.0126802902037392 75 50 3 0.06 0.04
GO:BP GO:0042330 taxis 0.0127882559303247 656 87 10 0.114942528735632 0.0152439024390244
GO:BP GO:0038084 vascular endothelial growth factor signaling pathway 0.0128956135433768 54 70 3 0.0428571428571429 0.0555555555555556
GO:BP GO:0009123 nucleoside monophosphate metabolic process 0.0130310823312236 76 50 3 0.06 0.0394736842105263
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0131780360364968 745 6 3 0.5 0.00402684563758389
GO:BP GO:0010506 regulation of autophagy 0.0131780360364968 336 12 3 0.25 0.00892857142857143
GO:BP GO:0016485 protein processing 0.0131780360364968 235 92 6 0.0652173913043478 0.025531914893617
GO:BP GO:0046394 carboxylic acid biosynthetic process 0.0131780360364968 330 66 6 0.0909090909090909 0.0181818181818182
GO:BP GO:0031623 receptor internalization 0.0134013654649592 116 74 4 0.0540540540540541 0.0344827586206897
GO:BP GO:0051649 establishment of localization in cell 0.01350786678841 2813 92 26 0.282608695652174 0.00924280127977248
GO:BP GO:0010508 positive regulation of autophagy 0.0136558660152598 124 70 4 0.0571428571428571 0.032258064516129
GO:BP GO:1901700 response to oxygen-containing compound 0.0136558660152598 1739 87 18 0.206896551724138 0.0103507763082231
GO:BP GO:0032868 response to insulin 0.014000948913258 295 75 6 0.08 0.0203389830508475
GO:BP GO:0001568 blood vessel development 0.0141014446953391 792 87 11 0.126436781609195 0.0138888888888889
GO:BP GO:0016053 organic acid biosynthetic process 0.0142923205668929 338 66 6 0.0909090909090909 0.0177514792899408
GO:BP GO:0010942 positive regulation of cell death 0.0143317234331232 684 23 5 0.217391304347826 0.00730994152046784
GO:BP GO:0055080 cation homeostasis 0.0143317234331232 750 92 11 0.119565217391304 0.0146666666666667
GO:BP GO:0051179 localization 0.0164091731443853 6901 89 48 0.539325842696629 0.00695551369366758
GO:BP GO:0006897 endocytosis 0.0175800399167457 696 87 10 0.114942528735632 0.014367816091954
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.0175800399167457 253 92 6 0.0652173913043478 0.0237154150197628
GO:BP GO:0032502 developmental process 0.0176974010391935 6628 46 27 0.58695652173913 0.00407362703681352
GO:BP GO:0035239 tube morphogenesis 0.0179736246715025 950 87 12 0.137931034482759 0.0126315789473684
GO:BP GO:0019216 regulation of lipid metabolic process 0.0186382284645881 419 57 6 0.105263157894737 0.0143198090692124
GO:BP GO:1904659 glucose transmembrane transport 0.0186918024848441 112 86 4 0.0465116279069767 0.0357142857142857
GO:BP GO:0002684 positive regulation of immune system process 0.018882189509851 1065 89 13 0.146067415730337 0.0122065727699531
GO:BP GO:0009250 glucan biosynthetic process 0.018882189509851 50 91 3 0.032967032967033 0.06
GO:BP GO:0001944 vasculature development 0.018882189509851 830 87 11 0.126436781609195 0.0132530120481928
GO:BP GO:0005978 glycogen biosynthetic process 0.018882189509851 50 91 3 0.032967032967033 0.06
GO:BP GO:0048259 regulation of receptor-mediated endocytosis 0.0191947622939772 112 87 4 0.0459770114942529 0.0357142857142857
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0192902400005865 1202 89 14 0.157303370786517 0.0116472545757072
GO:BP GO:0042116 macrophage activation 0.0193503035591804 110 89 4 0.0449438202247191 0.0363636363636364
GO:BP GO:0006914 autophagy 0.0196048613310388 543 19 4 0.210526315789474 0.00736648250460405
GO:BP GO:0061919 process utilizing autophagic mechanism 0.0196048613310388 543 19 4 0.210526315789474 0.00736648250460405
GO:BP GO:0009611 response to wounding 0.0198211164641865 674 92 10 0.108695652173913 0.0148367952522255
GO:BP GO:0008645 hexose transmembrane transport 0.0198211164641865 115 86 4 0.0465116279069767 0.0347826086956522
GO:BP GO:0051716 cellular response to stimulus 0.020570357356043 7781 89 52 0.584269662921348 0.00668294563680761
GO:BP GO:0015749 monosaccharide transmembrane transport 0.0206653649560397 117 86 4 0.0465116279069767 0.0341880341880342
GO:BP GO:0071310 cellular response to organic substance 0.0207712259718342 2776 87 24 0.275862068965517 0.00864553314121038
GO:BP GO:0010466 negative regulation of peptidase activity 0.0210524050695879 267 92 6 0.0652173913043478 0.0224719101123595
GO:BP GO:0051049 regulation of transport 0.0210524050695879 1809 88 18 0.204545454545455 0.00995024875621891
GO:BP GO:0072359 circulatory system development 0.0213887584252229 1194 91 14 0.153846153846154 0.0117252931323283
GO:BP GO:0034219 carbohydrate transmembrane transport 0.0214343252598778 119 86 4 0.0465116279069767 0.0336134453781513
GO:BP GO:0051128 regulation of cellular component organization 0.0216408151433474 2412 24 9 0.375 0.00373134328358209
GO:BP GO:0042493 response to drug 0.0217046870534584 396 85 7 0.0823529411764706 0.0176767676767677
GO:BP GO:0031329 regulation of cellular catabolic process 0.0219198130370692 866 21 5 0.238095238095238 0.00577367205542725
GO:BP GO:0061024 membrane organization 0.0219198130370692 973 27 6 0.222222222222222 0.00616649537512847
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0221462198102687 470 92 8 0.0869565217391304 0.0170212765957447
GO:BP GO:0062012 regulation of small molecule metabolic process 0.0225081936410538 447 57 6 0.105263157894737 0.0134228187919463
GO:BP GO:0006839 mitochondrial transport 0.0247665955545137 284 19 3 0.157894736842105 0.0105633802816901
GO:BP GO:0048856 anatomical structure development 0.0251217511073103 6106 46 25 0.543478260869565 0.00409433344251556
GO:BP GO:0035295 tube development 0.0251217511073103 1146 87 13 0.149425287356322 0.0113438045375218
GO:BP GO:0006979 response to oxidative stress 0.0251217511073103 466 12 3 0.25 0.00643776824034335
GO:BP GO:0002931 response to ischemia 0.0252944721301334 58 92 3 0.0326086956521739 0.0517241379310345
GO:BP GO:0009116 nucleoside metabolic process 0.0252944721301334 107 50 3 0.06 0.0280373831775701
GO:BP GO:0042593 glucose homeostasis 0.0255783976666455 248 73 5 0.0684931506849315 0.0201612903225806
GO:BP GO:0033500 carbohydrate homeostasis 0.0258838615100723 249 73 5 0.0684931506849315 0.0200803212851406
GO:BP GO:0015909 long-chain fatty acid transport 0.0267803021141511 75 73 3 0.0410958904109589 0.04
GO:BP GO:0030100 regulation of endocytosis 0.0272344295158671 212 87 5 0.0574712643678161 0.0235849056603774
GO:BP GO:0035924 cellular response to vascular endothelial growth factor stimulus 0.0281054062976927 81 70 3 0.0428571428571429 0.037037037037037
GO:BP GO:0071219 cellular response to molecule of bacterial origin 0.0281054062976927 214 87 5 0.0574712643678161 0.0233644859813084
GO:BP GO:0071677 positive regulation of mononuclear cell migration 0.0281054062976927 65 87 3 0.0344827586206897 0.0461538461538462
GO:BP GO:0043086 negative regulation of catalytic activity 0.0282846007192929 851 92 11 0.119565217391304 0.0129259694477086
GO:BP GO:0032879 regulation of localization 0.0282846007192929 2872 92 25 0.271739130434783 0.00870473537604457
GO:BP GO:0040007 growth 0.0297198984502202 967 82 11 0.134146341463415 0.0113753877973113
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.0300914833492931 536 87 8 0.0919540229885057 0.0149253731343284
GO:BP GO:0010628 positive regulation of gene expression 0.0303074783214034 1160 89 13 0.146067415730337 0.0112068965517241
GO:BP GO:0007005 mitochondrion organization 0.0303184744964756 561 22 4 0.181818181818182 0.0071301247771836
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.0304972284790627 222 87 5 0.0574712643678161 0.0225225225225225
GO:BP GO:0031667 response to nutrient levels 0.0308153532702043 482 41 5 0.121951219512195 0.0103734439834025
GO:BP GO:0010001 glial cell differentiation 0.0308153532702043 225 27 3 0.111111111111111 0.0133333333333333
GO:BP GO:0050865 regulation of cell activation 0.0318552156329288 655 89 9 0.101123595505618 0.0137404580152672
GO:BP GO:0030855 epithelial cell differentiation 0.031883385732572 798 87 10 0.114942528735632 0.012531328320802
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0326332246210068 539 89 8 0.0898876404494382 0.0148423005565863
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0334453036871248 1132 19 5 0.263157894736842 0.00441696113074205
GO:BP GO:0009615 response to virus 0.0334453036871248 364 18 3 0.166666666666667 0.00824175824175824
GO:BP GO:0050729 positive regulation of inflammatory response 0.0335363726693516 142 89 4 0.0449438202247191 0.028169014084507
GO:BP GO:0006954 inflammatory response 0.0347305324295652 794 89 10 0.112359550561798 0.0125944584382872
GO:BP GO:1901657 glycosyl compound metabolic process 0.0347803597380007 130 50 3 0.06 0.0230769230769231
GO:BP GO:0043065 positive regulation of apoptotic process 0.0347814615921861 604 22 4 0.181818181818182 0.00662251655629139
GO:BP GO:0052548 regulation of endopeptidase activity 0.0348524455642078 437 30 4 0.133333333333333 0.0091533180778032
GO:BP GO:0051651 maintenance of location in cell 0.0348728902826035 223 92 5 0.0543478260869565 0.0224215246636771
GO:BP GO:0043112 receptor metabolic process 0.0349642090328878 174 74 4 0.0540540540540541 0.0229885057471264
GO:BP GO:0009894 regulation of catabolic process 0.0349642090328878 1033 21 5 0.238095238095238 0.00484027105517909
GO:BP GO:1901653 cellular response to peptide 0.0350661663316669 408 51 5 0.0980392156862745 0.0122549019607843
GO:BP GO:0009991 response to extracellular stimulus 0.0351099600069092 512 41 5 0.121951219512195 0.009765625
GO:BP GO:0071216 cellular response to biotic stimulus 0.0353272256157489 238 87 5 0.0574712643678161 0.0210084033613445
GO:BP GO:0051235 maintenance of location 0.035823732535584 337 62 5 0.0806451612903226 0.0148367952522255
GO:BP GO:0009636 response to toxic substance 0.0365969949404728 243 28 3 0.107142857142857 0.0123456790123457
GO:BP GO:0043068 positive regulation of programmed cell death 0.0366017861290802 621 22 4 0.181818181818182 0.00644122383252818
GO:BP GO:2000106 regulation of leukocyte apoptotic process 0.0366017861290802 82 82 3 0.0365853658536585 0.0365853658536585
GO:BP GO:0008643 carbohydrate transport 0.0369820592373497 154 86 4 0.0465116279069767 0.025974025974026
GO:BP GO:0019538 protein metabolic process 0.0369820592373497 5808 15 10 0.666666666666667 0.00172176308539945
GO:BP GO:0018193 peptidyl-amino acid modification 0.0373283842715869 1303 6 3 0.5 0.00230237912509593
GO:BP GO:0033692 cellular polysaccharide biosynthetic process 0.0374515031656368 75 91 3 0.032967032967033 0.04
GO:BP GO:0048523 negative regulation of cellular process 0.0385752042916754 5139 19 11 0.578947368421053 0.00214049425958358
GO:BP GO:0034248 regulation of cellular amide metabolic process 0.0388528064591402 535 26 4 0.153846153846154 0.00747663551401869
GO:BP GO:0052547 regulation of peptidase activity 0.040046362747281 467 30 4 0.133333333333333 0.00856531049250535
GO:BP GO:0030162 regulation of proteolysis 0.0409759611074021 752 30 5 0.166666666666667 0.00664893617021277
GO:BP GO:0034097 response to cytokine 0.0410270423969892 1226 19 5 0.263157894736842 0.00407830342577488
GO:BP GO:0045087 innate immune response 0.0410270423969892 998 23 5 0.217391304347826 0.00501002004008016
GO:BP GO:0005977 glycogen metabolic process 0.0410270423969892 79 91 3 0.032967032967033 0.0379746835443038
GO:BP GO:0009653 anatomical structure morphogenesis 0.0417935843768948 2797 89 23 0.258426966292135 0.00822309617447265
GO:BP GO:0044042 glucan metabolic process 0.0420749721701418 80 91 3 0.032967032967033 0.0375
GO:BP GO:0006073 cellular glucan metabolic process 0.0420749721701418 80 91 3 0.032967032967033 0.0375
GO:BP GO:1903530 regulation of secretion by cell 0.0426560124582635 588 88 8 0.0909090909090909 0.0136054421768707
GO:BP GO:0002237 response to molecule of bacterial origin 0.0429471690525675 361 87 6 0.0689655172413793 0.0166204986149584
GO:BP GO:0000271 polysaccharide biosynthetic process 0.0430273924225263 81 91 3 0.032967032967033 0.037037037037037
GO:BP GO:0120035 regulation of plasma membrane bounded cell projection organization 0.0430273924225263 638 23 4 0.173913043478261 0.00626959247648903
GO:BP GO:0042113 B cell activation 0.0437071953868088 330 23 3 0.130434782608696 0.00909090909090909
GO:BP GO:0031589 cell-substrate adhesion 0.0453694492990252 367 87 6 0.0689655172413793 0.0163487738419619
GO:BP GO:0046330 positive regulation of JNK cascade 0.0457498912145029 86 89 3 0.0337078651685393 0.0348837209302326
GO:BP GO:0031344 regulation of cell projection organization 0.0457498912145029 656 23 4 0.173913043478261 0.00609756097560976
GO:BP GO:0006874 cellular calcium ion homeostasis 0.0457498912145029 460 92 7 0.0760869565217391 0.0152173913043478
GO:BP GO:0002065 columnar/cuboidal epithelial cell differentiation 0.0457498912145029 89 87 3 0.0344827586206897 0.0337078651685393
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.046542407829449 167 89 4 0.0449438202247191 0.0239520958083832
GO:BP GO:0032760 positive regulation of tumor necrosis factor production 0.0466804978083402 88 89 3 0.0337078651685393 0.0340909090909091
GO:BP GO:2000377 regulation of reactive oxygen species metabolic process 0.0470569912359122 203 39 3 0.0769230769230769 0.0147783251231527
GO:BP GO:0043434 response to peptide hormone 0.0471801311745459 462 51 5 0.0980392156862745 0.0108225108225108
GO:BP GO:0043408 regulation of MAPK cascade 0.0472579235272484 730 89 9 0.101123595505618 0.0123287671232877
GO:BP GO:0032501 multicellular organismal process 0.0473653514552185 7946 92 52 0.565217391304348 0.00654417316889001
GO:BP GO:0030155 regulation of cell adhesion 0.0473653514552185 748 87 9 0.103448275862069 0.0120320855614973
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.0479888557721324 170 89 4 0.0449438202247191 0.0235294117647059
GO:BP GO:0044267 cellular protein metabolic process 0.048262623111063 5229 22 12 0.545454545454545 0.00229489386115892
GO:BP GO:0055074 calcium ion homeostasis 0.048262623111063 472 92 7 0.0760869565217391 0.0148305084745763
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.048262623111063 360 92 6 0.0652173913043478 0.0166666666666667
GO:BP GO:0002694 regulation of leukocyte activation 0.048262623111063 610 89 8 0.0898876404494382 0.0131147540983607
GO:BP GO:0044237 cellular metabolic process 0.048262623111063 10871 9 9 1 0.000827890718425168
GO:BP GO:0042180 cellular ketone metabolic process 0.0488910737731644 271 57 4 0.0701754385964912 0.014760147601476
GO:BP GO:0050793 regulation of developmental process 0.0490832339799424 2605 87 21 0.241379310344828 0.00806142034548944
GO:BP GO:0050789 regulation of biological process 0.0492425872520086 12091 47 39 0.829787234042553 0.00322553965759656
GO:BP GO:0042063 gliogenesis 0.0492425872520086 308 27 3 0.111111111111111 0.00974025974025974
GO:CC GO:0043230 extracellular organelle 1.20065035643739e-08 2263 48 24 0.5 0.0106053910737958
GO:CC GO:0070062 extracellular exosome 1.20065035643739e-08 2176 48 24 0.5 0.0110294117647059
GO:CC GO:1903561 extracellular vesicle 1.20065035643739e-08 2261 48 24 0.5 0.0106147722246793
GO:CC GO:0030141 secretory granule 1.48576166769261e-07 851 89 20 0.224719101123595 0.0235017626321974
GO:CC GO:0031982 vesicle 2.73827315387427e-07 4055 89 44 0.49438202247191 0.0108508014796547
GO:CC GO:0099503 secretory vesicle 3.79633026174098e-07 1020 89 21 0.235955056179775 0.0205882352941176
GO:CC GO:0101002 ficolin-1-rich granule 4.97577657527598e-07 184 64 9 0.140625 0.0489130434782609
GO:CC GO:0005615 extracellular space 7.24414040448075e-07 3594 89 40 0.449438202247191 0.0111296605453534
GO:CC GO:0070820 tertiary granule 2.55853316460168e-06 163 89 9 0.101123595505618 0.0552147239263804
GO:CC GO:1904813 ficolin-1-rich granule lumen 2.55853316460168e-06 124 34 6 0.176470588235294 0.0483870967741935
GO:CC GO:1904724 tertiary granule lumen 6.30351329517062e-06 55 89 6 0.0674157303370786 0.109090909090909
GO:CC GO:0034774 secretory granule lumen 7.40733279563273e-06 320 89 11 0.123595505617978 0.034375
GO:CC GO:0012505 endomembrane system 7.40733279563273e-06 4640 89 44 0.49438202247191 0.00948275862068966
GO:CC GO:0031983 vesicle lumen 7.72237965705392e-06 326 89 11 0.123595505617978 0.0337423312883436
GO:CC GO:0060205 cytoplasmic vesicle lumen 7.72237965705392e-06 324 89 11 0.123595505617978 0.0339506172839506
GO:CC GO:0005576 extracellular region 1.1194964301682e-05 4567 89 43 0.48314606741573 0.00941537114079264
GO:CC GO:0005737 cytoplasm 2.22178693035894e-05 11911 52 48 0.923076923076923 0.00402988833851062
GO:CC GO:0097708 intracellular vesicle 5.74376537728778e-05 2428 89 28 0.314606741573034 0.0115321252059308
GO:CC GO:0031410 cytoplasmic vesicle 5.74376537728778e-05 2424 89 28 0.314606741573034 0.0115511551155116
GO:CC GO:0005829 cytosol 0.000129881351201137 5303 50 29 0.58 0.00546860267772959
GO:CC GO:0009986 cell surface 0.000625636917915396 899 85 14 0.164705882352941 0.0155728587319244
GO:CC GO:0031091 platelet alpha granule 0.000812581810495698 90 87 5 0.0574712643678161 0.0555555555555556
GO:CC GO:0062023 collagen-containing extracellular matrix 0.00212018196834636 421 89 9 0.101123595505618 0.0213776722090261
GO:CC GO:0031093 platelet alpha granule lumen 0.00306152094348238 66 87 4 0.0459770114942529 0.0606060606060606
GO:CC GO:0005788 endoplasmic reticulum lumen 0.00326466463901126 307 20 4 0.2 0.0130293159609121
GO:CC GO:0043227 membrane-bounded organelle 0.00373198302517684 12858 49 44 0.897959183673469 0.00342199408928294
GO:CC GO:0030667 secretory granule membrane 0.00517217697131152 303 86 7 0.0813953488372093 0.0231023102310231
GO:CC GO:0098588 bounding membrane of organelle 0.00569708936300148 2158 86 21 0.244186046511628 0.00973123262279889
GO:CC GO:0005783 endoplasmic reticulum 0.00573854043437327 1982 51 14 0.274509803921569 0.0070635721493441
GO:CC GO:0001917 photoreceptor inner segment 0.00573854043437327 61 50 3 0.06 0.0491803278688525
GO:CC GO:0005741 mitochondrial outer membrane 0.00742622817533402 202 39 4 0.102564102564103 0.0198019801980198
GO:CC GO:0016020 membrane 0.00746366901474563 9838 48 36 0.75 0.00365928034153283
GO:CC GO:0042581 specific granule 0.00746366901474563 158 89 5 0.0561797752808989 0.0316455696202532
GO:CC GO:0031012 extracellular matrix 0.00746366901474563 562 26 5 0.192307692307692 0.00889679715302491
GO:CC GO:0030312 external encapsulating structure 0.00746366901474563 563 26 5 0.192307692307692 0.0088809946714032
GO:CC GO:0031968 organelle outer membrane 0.00921836298795779 227 39 4 0.102564102564103 0.0176211453744493
GO:CC GO:0019867 outer membrane 0.00929501884048287 229 39 4 0.102564102564103 0.0174672489082969
GO:CC GO:0070821 tertiary granule membrane 0.0101129377950779 72 58 3 0.0517241379310345 0.0416666666666667
GO:CC GO:0031090 organelle membrane 0.0133851689277867 3612 86 28 0.325581395348837 0.00775193798449612
GO:CC GO:0005635 nuclear envelope 0.0173096940403921 467 12 3 0.25 0.00642398286937901
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0173096940403921 779 86 10 0.116279069767442 0.0128369704749679
GO:CC GO:0005791 rough endoplasmic reticulum 0.0193408055204319 86 65 3 0.0461538461538462 0.0348837209302326
GO:CC GO:0012506 vesicle membrane 0.0195211367195118 800 86 10 0.116279069767442 0.0125
GO:CC GO:0005634 nucleus 0.0228130138713744 7592 14 11 0.785714285714286 0.00144889357218124
GO:CC GO:0043226 organelle 0.0258641189790763 14008 96 82 0.854166666666667 0.00585379782981154
GO:CC GO:0016529 sarcoplasmic reticulum 0.0258641189790763 70 92 3 0.0326086956521739 0.0428571428571429
GO:CC GO:0045121 membrane raft 0.0261602037033571 335 63 5 0.0793650793650794 0.0149253731343284
GO:CC GO:0098857 membrane microdomain 0.0261602037033571 335 63 5 0.0793650793650794 0.0149253731343284
GO:CC GO:0031967 organelle envelope 0.0274099651128172 1237 12 4 0.333333333333333 0.00323362974939369
GO:CC GO:0005739 mitochondrion 0.0274099651128172 1673 32 8 0.25 0.00478182904961148
GO:CC GO:0005622 intracellular anatomical structure 0.0274099651128172 14790 52 48 0.923076923076923 0.00324543610547667
GO:CC GO:0031966 mitochondrial membrane 0.0274099651128172 746 19 4 0.210526315789474 0.00536193029490617
GO:CC GO:0031975 envelope 0.0274099651128172 1237 12 4 0.333333333333333 0.00323362974939369
GO:CC GO:0030017 sarcomere 0.0286754767379694 208 67 4 0.0597014925373134 0.0192307692307692
GO:CC GO:0016528 sarcoplasm 0.0301068404102134 79 92 3 0.0326086956521739 0.0379746835443038
GO:CC GO:0005740 mitochondrial envelope 0.0312478731208029 797 19 4 0.210526315789474 0.00501882057716437
GO:CC GO:0071944 cell periphery 0.0315685324530144 6169 45 23 0.511111111111111 0.00372831901442697
GO:CC GO:0035579 specific granule membrane 0.0324990610912219 90 86 3 0.0348837209302326 0.0333333333333333
GO:CC GO:0030016 myofibril 0.0351637579372556 231 67 4 0.0597014925373134 0.0173160173160173
GO:CC GO:0043292 contractile fiber 0.0391051653511841 240 67 4 0.0597014925373134 0.0166666666666667
GO:CC GO:0030139 endocytic vesicle 0.0394875459120465 306 82 5 0.0609756097560976 0.0163398692810458
GO:CC GO:0031674 I band 0.047583742880289 139 67 3 0.0447761194029851 0.0215827338129496
GO:MF GO:0048029 monosaccharide binding 1.66856371890143e-11 71 91 11 0.120879120879121 0.154929577464789
GO:MF GO:0030246 carbohydrate binding 1.31933966276427e-08 275 91 14 0.153846153846154 0.0509090909090909
GO:MF GO:0016860 intramolecular oxidoreductase activity 2.9761737580558e-05 53 47 5 0.106382978723404 0.0943396226415094
GO:MF GO:0042802 identical protein binding 3.21361241403652e-05 2067 48 19 0.395833333333333 0.00919206579583938
GO:MF GO:0031418 L-ascorbic acid binding 0.000189361491052809 21 85 4 0.0470588235294118 0.19047619047619
GO:MF GO:0016853 isomerase activity 0.000277685334293331 169 47 6 0.127659574468085 0.0355029585798817
GO:MF GO:0016491 oxidoreductase activity 0.000358510864094007 771 8 5 0.625 0.00648508430609598
GO:MF GO:0005536 glucose binding 0.000845893551811019 11 91 3 0.032967032967033 0.272727272727273
GO:MF GO:0016829 lyase activity 0.00148744644774682 203 85 7 0.0823529411764706 0.0344827586206897
GO:MF GO:0016835 carbon-oxygen lyase activity 0.00249686865487414 81 54 4 0.0740740740740741 0.0493827160493827
GO:MF GO:0005355 glucose transmembrane transporter activity 0.00291744813748115 21 86 3 0.0348837209302326 0.142857142857143
GO:MF GO:0015149 hexose transmembrane transporter activity 0.00291744813748115 21 86 3 0.0348837209302326 0.142857142857143
GO:MF GO:0015145 monosaccharide transmembrane transporter activity 0.00308733309256902 23 86 3 0.0348837209302326 0.130434782608696
GO:MF GO:0036094 small molecule binding 0.00308733309256902 2506 93 26 0.279569892473118 0.0103750997605746
GO:MF GO:0045296 cadherin binding 0.00352644219145498 333 48 6 0.125 0.018018018018018
GO:MF GO:0051119 sugar transmembrane transporter activity 0.00352644219145498 25 86 3 0.0348837209302326 0.12
GO:MF GO:0015144 carbohydrate transmembrane transporter activity 0.00825844280482998 38 86 3 0.0348837209302326 0.0789473684210526
GO:MF GO:0016836 hydro-lyase activity 0.00900716338428114 65 54 3 0.0555555555555556 0.0461538461538462
GO:MF GO:0003824 catalytic activity 0.00962695688036953 5896 6 6 1 0.00101763907734057
GO:MF GO:0050839 cell adhesion molecule binding 0.0104947526236888 546 58 7 0.120689655172414 0.0128205128205128
GO:MF GO:0016706 2-oxoglutarate-dependent dioxygenase activity 0.0104947526236888 48 81 3 0.037037037037037 0.0625
GO:MF GO:0042803 protein homodimerization activity 0.0104947526236888 676 24 5 0.208333333333333 0.00739644970414201
GO:MF GO:0004866 endopeptidase inhibitor activity 0.0116992378108096 176 92 5 0.0543478260869565 0.0284090909090909
GO:MF GO:0043177 organic acid binding 0.0128240506553051 120 85 4 0.0470588235294118 0.0333333333333333
GO:MF GO:0016772 transferase activity, transferring phosphorus-containing groups 0.0150971632611474 952 93 12 0.129032258064516 0.0126050420168067
GO:MF GO:0016301 kinase activity 0.0151770461194089 796 57 8 0.140350877192982 0.0100502512562814
GO:MF GO:0004857 enzyme inhibitor activity 0.0153529658638572 385 92 7 0.0760869565217391 0.0181818181818182
GO:MF GO:0019842 vitamin binding 0.019784577999775 149 85 4 0.0470588235294118 0.0268456375838926
GO:MF GO:0000166 nucleotide binding 0.0217365395359273 2171 70 16 0.228571428571429 0.00736987563334869
GO:MF GO:1901265 nucleoside phosphate binding 0.0217365395359273 2172 70 16 0.228571428571429 0.00736648250460405
GO:MF GO:0000287 magnesium ion binding 0.0251699206542924 222 33 3 0.0909090909090909 0.0135135135135135
GO:MF GO:0046914 transition metal ion binding 0.0251699206542924 1111 90 12 0.133333333333333 0.0108010801080108
GO:MF GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 0.0253490424104785 167 85 4 0.0470588235294118 0.0239520958083832
GO:MF GO:0005515 protein binding 0.0259614439491811 14767 46 43 0.934782608695652 0.00291189815128327
GO:MF GO:0051213 dioxygenase activity 0.0280249035027691 96 81 3 0.037037037037037 0.03125
GO:MF GO:0001664 G protein-coupled receptor binding 0.0303687063865097 292 82 5 0.0609756097560976 0.0171232876712329
GO:MF GO:0046983 protein dimerization activity 0.0321345265928915 1069 24 5 0.208333333333333 0.00467726847521048
GO:MF GO:0051020 GTPase binding 0.034439116330164 330 27 3 0.111111111111111 0.00909090909090909
GO:MF GO:0031406 carboxylic acid binding 0.0346792635976138 194 85 4 0.0470588235294118 0.0206185567010309
GO:MF GO:0019899 enzyme binding 0.0352103886053981 2074 41 10 0.24390243902439 0.00482160077145612
GO:MF GO:0008270 zinc ion binding 0.0465747439685289 833 90 9 0.1 0.0108043217286915
GO:MF GO:0005125 cytokine activity 0.0477961417108344 235 82 4 0.0487804878048781 0.0170212765957447
GO:MF GO:0019838 growth factor binding 0.047885234747683 138 78 3 0.0384615384615385 0.0217391304347826
GO:MF GO:0008509 anion transmembrane transporter activity 0.047885234747683 464 86 6 0.0697674418604651 0.0129310344827586
KEGG KEGG:00010 Glycolysis / Gluconeogenesis 2.72508886595866e-13 67 34 11 0.323529411764706 0.164179104477612
KEGG KEGG:04066 HIF-1 signaling pathway 4.14885507199935e-11 109 87 15 0.172413793103448 0.137614678899083
KEGG KEGG:01230 Biosynthesis of amino acids 7.05861801405902e-10 75 64 11 0.171875 0.146666666666667
KEGG KEGG:01200 Carbon metabolism 1.24821357761786e-09 116 34 10 0.294117647058824 0.0862068965517241
KEGG KEGG:05230 Central carbon metabolism in cancer 5.14376552667353e-06 70 70 8 0.114285714285714 0.114285714285714
KEGG KEGG:00051 Fructose and mannose metabolism 0.000171125759097192 33 64 5 0.078125 0.151515151515152
KEGG KEGG:00500 Starch and sucrose metabolism 0.00127827643858032 36 91 5 0.0549450549450549 0.138888888888889
KEGG KEGG:00030 Pentose phosphate pathway 0.00200769400289928 30 64 4 0.0625 0.133333333333333
KEGG KEGG:01100 Metabolic pathways 0.0069981940237258 1490 50 20 0.4 0.0134228187919463
KEGG KEGG:04922 Glucagon signaling pathway 0.00776747555073344 107 48 5 0.104166666666667 0.0467289719626168
KEGG KEGG:04978 Mineral absorption 0.015008498440831 59 59 4 0.0677966101694915 0.0677966101694915
KEGG KEGG:00052 Galactose metabolism 0.0313311392754693 31 66 3 0.0454545454545455 0.0967741935483871
MIRNA MIRNA:hsa-miR-320a hsa-miR-320a 0.0299091702364274 584 41 9 0.219512195121951 0.0154109589041096
MIRNA MIRNA:hsa-miR-331-3p hsa-miR-331-3p 0.0482127626648562 403 4 3 0.75 0.00744416873449132
REAC REAC:R-HSA-70263 Gluconeogenesis 1.34812927030318e-11 32 34 8 0.235294117647059 0.25
REAC REAC:R-HSA-70171 Glycolysis 2.32346116989039e-11 67 64 11 0.171875 0.164179104477612
REAC REAC:R-HSA-70326 Glucose metabolism 2.36561914422515e-10 85 64 11 0.171875 0.129411764705882
REAC REAC:R-HSA-71387 Metabolism of carbohydrates 1.13829520873906e-08 285 66 15 0.227272727272727 0.0526315789473684
REAC REAC:R-HSA-5661231 Metallothioneins bind metals 1.59319319270807e-05 11 59 4 0.0677966101694915 0.363636363636364
REAC REAC:R-HSA-5660526 Response to metal ions 3.97704645354529e-05 14 59 4 0.0677966101694915 0.285714285714286
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.000309319981503472 474 89 15 0.168539325842697 0.0316455696202532
REAC REAC:R-HSA-1430728 Metabolism 0.000803633633007565 2070 57 25 0.43859649122807 0.0120772946859903
REAC REAC:R-HSA-76002 Platelet activation, signaling and aggregation 0.00746157269608254 258 87 9 0.103448275862069 0.0348837209302326
REAC REAC:R-HSA-3322077 Glycogen synthesis 0.00820381914422683 16 91 3 0.032967032967033 0.1875
REAC REAC:R-HSA-114608 Platelet degranulation 0.0122765457228743 125 87 6 0.0689655172413793 0.048
REAC REAC:R-HSA-70268 Pyruvate metabolism 0.0122765457228743 30 57 3 0.0526315789473684 0.1
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.013090540111563 130 87 6 0.0689655172413793 0.0461538461538462
REAC REAC:R-HSA-8982491 Glycogen metabolism 0.0245963876211535 27 91 3 0.032967032967033 0.111111111111111
REAC REAC:R-HSA-114604 GPVI-mediated activation cascade 0.0245963876211535 35 70 3 0.0428571428571429 0.0857142857142857
REAC REAC:R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 0.0452123842279829 54 57 3 0.0526315789473684 0.0555555555555556
TF TF:M07043 Factor: HIF-1alpha; motif: NNACGTGNN 9.95068733588542e-07 1439 37 17 0.459459459459459 0.0118137595552467
TF TF:M09773 Factor: HIF1A; motif: NNACGTGCNN 9.21808440212859e-05 2413 63 25 0.396825396825397 0.0103605470368835
TF TF:M00797 Factor: HIF1; motif: GNNKACGTGCGGNN 0.000161074063485183 3576 63 30 0.476190476190476 0.00838926174496644
TF TF:M09944 Factor: HIF-1alpha; motif: GNACGTGM 0.000164735345073815 5581 63 38 0.603174603174603 0.00680881562444006
TF TF:M09906 Factor: HIF2A; motif: NTACGTGMN 0.000559137918962875 933 86 17 0.197674418604651 0.0182207931404073
TF TF:M02012 Factor: HIF-1alpha; motif: NCACGT 0.000649098776980451 6648 64 41 0.640625 0.00616726835138388
TF TF:M04744 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA 0.00072358270783806 10089 57 47 0.824561403508772 0.00465853900287442
TF TF:M09944_1 Factor: HIF-1alpha; motif: GNACGTGM; match class: 1 0.0011150645189238 1384 19 9 0.473684210526316 0.0065028901734104
TF TF:M02378 Factor: HIF1A:ARNT; motif: VNACGTGN 0.0011150645189238 856 62 13 0.209677419354839 0.0151869158878505
TF TF:M01249 Factor: HIF2alpha; motif: NNACGTGCNN 0.0011150645189238 1509 54 16 0.296296296296296 0.0106030483764082
TF TF:M08800 Factor: ARNT; motif: YRCGTGNN 0.0011150645189238 914 34 10 0.294117647058824 0.0109409190371991
TF TF:M07356 Factor: HIF2A; motif: ACGTGNNN 0.00149014322229528 1852 37 14 0.378378378378378 0.00755939524838013
TF TF:M09864 Factor: arnt; motif: NTACGTGMC 0.00185049552700817 896 37 10 0.27027027027027 0.0111607142857143
TF TF:M00650_1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 0.002156536786236 24 28 3 0.107142857142857 0.125
TF TF:M02012_1 Factor: HIF-1alpha; motif: NCACGT; match class: 1 0.00263386077684061 1770 63 18 0.285714285714286 0.0101694915254237
TF TF:M03812 Factor: arnt; motif: CACGYA 0.00442164577941382 4330 93 39 0.419354838709677 0.00900692840646651
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.00604155357735344 10023 56 44 0.785714285714286 0.00438990322258805
TF TF:M11022_1 Factor: IRX2a; motif: ACRYGNNNNACRYGT; match class: 1 0.00661914103213825 6246 65 37 0.569230769230769 0.00592379122638489
TF TF:M00466_1 Factor: HIF1; motif: NGTACGTGCNGB; match class: 1 0.00661914103213825 407 74 9 0.121621621621622 0.0221130221130221
TF TF:M07041_1 Factor: HDAC1; motif: KGCARGGTC; match class: 1 0.00661914103213825 6354 64 37 0.578125 0.00582310355681461
TF TF:M04744_1 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 0.00689314352789028 4889 39 22 0.564102564102564 0.00449989772959705
TF TF:M10014_1 Factor: FXR; motif: NRGGKCANTGRCCNNNNGG; match class: 1 0.00781876062788601 1498 81 18 0.222222222222222 0.0120160213618158
TF TF:M09762 Factor: NF1B; motif: CYTGGCNYNCWGCCAN 0.0082627032390818 5659 92 45 0.489130434782609 0.00795193497084291
TF TF:M11022 Factor: IRX2a; motif: ACRYGNNNNACRYGT 0.00981276049264817 9487 61 45 0.737704918032787 0.00474333298197533
TF TF:M04950_1 Factor: Egr-1; motif: NGCGTGCGY; match class: 1 0.0105566894928181 5551 41 24 0.585365853658537 0.00432354530715186
TF TF:M07103 Factor: JunB; motif: NRRTGASTCAK 0.0114033538719975 2383 96 26 0.270833333333333 0.0109106168694922
TF TF:M07091 Factor: Fra-1; motif: RRTGASTCAKN 0.0117035485916692 1716 88 20 0.227272727272727 0.0116550116550117
TF TF:M00481 Factor: AR; motif: GGTACANNRTGTTCT 0.0119578150757758 4981 67 32 0.477611940298507 0.00642441276852038
TF TF:M01298_1 Factor: MECP2; motif: CCGGSNNNANNAWWT; match class: 1 0.0169151518731393 54 31 3 0.0967741935483871 0.0555555555555556
TF TF:M04515 Factor: E2F-1; motif: WWTGGCGCCAAA 0.0169428595801727 13334 58 52 0.896551724137931 0.00389980500974951
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.0170239149461371 14106 67 61 0.91044776119403 0.00432440096412874
TF TF:M09631 Factor: JunB; motif: NNNTGAGTCAY 0.0170239149461371 1915 96 22 0.229166666666667 0.0114882506527415
TF TF:M04211 Factor: DBP; motif: NRTTACGTAAYN 0.0170239149461371 160 60 5 0.0833333333333333 0.03125
TF TF:M04950 Factor: Egr-1; motif: NGCGTGCGY 0.0170239149461371 10935 55 44 0.8 0.00402377686328304
TF TF:M03895 Factor: CTCF; motif: WGCGCCMYCTAGYGGYN 0.0170239149461371 9251 93 62 0.666666666666667 0.00670197816452275
TF TF:M07600 Factor: C-Fos; motif: NNTGACTCAN 0.0170239149461371 2834 46 17 0.369565217391304 0.00599858856739591
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.0170239149461371 11467 60 49 0.816666666666667 0.00427313159501177
TF TF:M04211_1 Factor: DBP; motif: NRTTACGTAAYN; match class: 1 0.0170239149461371 160 60 5 0.0833333333333333 0.03125
TF TF:M00333 Factor: ZF5; motif: NRNGNGCGCGCWN 0.0170239149461371 15072 67 63 0.940298507462687 0.00417993630573248
TF TF:M04112_1 Factor: GMEB2; motif: TTACGYAM; match class: 1 0.0170239149461371 160 60 5 0.0833333333333333 0.03125
TF TF:M04504 Factor: GMEB2; motif: TTACGTAA 0.0170239149461371 160 60 5 0.0833333333333333 0.03125
TF TF:M04504_1 Factor: GMEB2; motif: TTACGTAA; match class: 1 0.0170239149461371 160 60 5 0.0833333333333333 0.03125
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.0170239149461371 16228 60 59 0.983333333333333 0.00363569139758442
TF TF:M04515_1 Factor: E2F-1; motif: WWTGGCGCCAAA; match class: 1 0.0181454368901297 12173 58 49 0.844827586206897 0.00402530189764232
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.0181689734379612 10230 58 44 0.758620689655172 0.0043010752688172
TF TF:M00925 Factor: AP-1; motif: NTGACTCAN 0.0181689734379612 2554 96 26 0.270833333333333 0.0101801096319499
TF TF:M11331_1 Factor: Hlf; motif: NNTTACGTAANN; match class: 1 0.0181689734379612 168 60 5 0.0833333333333333 0.0297619047619048
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.0181689734379612 11232 60 48 0.8 0.00427350427350427
TF TF:M09670_1 Factor: USF2; motif: NGGTCACGTGNNSNNNNNN; match class: 1 0.0181689734379612 850 47 9 0.191489361702128 0.0105882352941176
TF TF:M09645 Factor: Pax-5; motif: NNNNRNKCAGCNRAGCGTGAC 0.0181689734379612 2596 79 23 0.291139240506329 0.0088597842835131
TF TF:M12173_1 Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 0.0181689734379612 4965 67 31 0.462686567164179 0.00624370594159114
TF TF:M12152 Factor: Sp1; motif: NWRGCCACGCCCMCN 0.0190314320583843 7341 95 53 0.557894736842105 0.007219724833129
TF TF:M04453_1 Factor: AR; motif: RGGWACAYNGTGTWCYN; match class: 1 0.01936698238893 3794 64 25 0.390625 0.00658935160780179
TF TF:M12186 Factor: BTEB4; motif: NCCACGCCCM 0.01936698238893 9135 67 46 0.686567164179104 0.00503557744937055
TF TF:M10161 Factor: ZNF667; motif: GNGSCYTNMARAGCTCMNC 0.0194654567027291 3556 5 5 1 0.00140607424071991
TF TF:M11052 Factor: Hey2; motif: NNCACGYGNN 0.0194654567027291 12502 64 54 0.84375 0.00431930891057431
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0212779398750901 13190 58 51 0.879310344827586 0.00386656557998484
TF TF:M04636 Factor: TFII-I; motif: NAGGAAGTGN 0.0212779398750901 12845 87 72 0.827586206896552 0.00560529388867264
TF TF:M00517_1 Factor: AP-1; motif: NNNTGAGTCAKCN; match class: 1 0.0212779398750901 3227 96 30 0.3125 0.0092965602726991
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.0212891013067891 14096 79 70 0.886075949367089 0.00496594778660613
TF TF:M03572 Factor: DEC1; motif: CNCACRTGASC 0.0213050495496446 6713 53 31 0.584905660377358 0.00461790555638314
TF TF:M02090_1 Factor: E2F-4; motif: GCGGGAAANA; match class: 1 0.021534695193161 6378 67 36 0.537313432835821 0.00564440263405456
TF TF:M01201 Factor: AR; motif: GGNACRNNRTGTWCT 0.021534695193161 6380 67 36 0.537313432835821 0.00564263322884012
TF TF:M08441 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG 0.0225240454031849 16345 44 44 1 0.00269195472621597
TF TF:M04112 Factor: GMEB2; motif: TTACGYAM 0.0225240454031849 292 60 6 0.1 0.0205479452054795
TF TF:M02090 Factor: E2F-4; motif: GCGGGAAANA 0.0225240454031849 11966 82 65 0.792682926829268 0.00543205749623934
TF TF:M00481_1 Factor: AR; motif: GGTACANNRTGTTCT; match class: 1 0.0226026636055566 2295 64 18 0.28125 0.00784313725490196
TF TF:M12085 Factor: ZNF501; motif: NNNCSACGCGAACAC 0.0233186777538223 8467 59 39 0.661016949152542 0.00460611786937522
TF TF:M04516 Factor: E2F-1; motif: TTTGGCGCCAAA 0.0254897667271057 11383 46 38 0.826086956521739 0.00333831151717473
TF TF:M09617 Factor: c-Fos; motif: RTGAGTCAYNN 0.0257425167700734 2663 96 26 0.270833333333333 0.00976342470897484
TF TF:M11081_1 Factor: SREBP-1; motif: RTCRCGTGAY; match class: 1 0.0258745167950124 7890 12 11 0.916666666666667 0.00139416983523447
TF TF:M11535 Factor: E2F-4; motif: TTTTGGCGCCAWWN 0.0261461638588388 10884 55 43 0.781818181818182 0.00395075339948548
TF TF:M00172 Factor: AP-1; motif: RSTGACTNMNW 0.0261461638588388 2280 10 6 0.6 0.00263157894736842
TF TF:M10157 Factor: ZNF554; motif: GCNGAGYCANNTRGNNNRCT 0.0289588823226413 1436 3 3 1 0.0020891364902507
TF TF:M11061_1 Factor: HES-1; motif: GGCRCGTGNC; match class: 1 0.0289588823226413 2453 47 15 0.319148936170213 0.00611496127191194
TF TF:M01201_1 Factor: AR; motif: GGNACRNNRTGTWCT; match class: 1 0.0300244985835245 2129 65 17 0.261538461538462 0.00798496946923438
TF TF:M00466 Factor: HIF1; motif: NGTACGTGCNGB 0.0309069567873872 2997 65 21 0.323076923076923 0.00700700700700701
TF TF:M08952_1 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN; match class: 1 0.0309479185613117 3457 65 23 0.353846153846154 0.00665316748625976
TF TF:M11330_1 Factor: Hlf; motif: NGTTRYGYAANN; match class: 1 0.0338098766423795 213 60 5 0.0833333333333333 0.0234741784037559
TF TF:M09969_1 Factor: EKLF; motif: NGGGYGKGGCNNGG; match class: 1 0.0341252389051695 1489 39 10 0.256410256410256 0.00671591672263264
TF TF:M09924 Factor: c-Fos; motif: NTGAGTCAN 0.0341252389051695 2431 96 24 0.25 0.00987248046071575
TF TF:M11533_1 Factor: E2F-1; motif: NTTTTGGCGCCAWWWN; match class: 1 0.0354521057498222 8705 83 52 0.626506024096386 0.00597357840321654
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.0355007023157818 10253 63 46 0.73015873015873 0.0044864917585097
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.0356611668997563 3020 79 24 0.30379746835443 0.00794701986754967
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.0356611668997563 16103 60 58 0.966666666666667 0.00360181332670931
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.0365583643502783 8492 83 51 0.614457831325301 0.00600565237870937
TF TF:M10026 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN 0.0373520258064491 8389 15 13 0.866666666666667 0.00154964834902849
TF TF:M11066_1 Factor: HES-7; motif: GNCACGYGNN; match class: 1 0.0377181819464873 8172 47 31 0.659574468085106 0.00379344101811062
TF TF:M03846 Factor: SMAD5; motif: GSGGCAGM 0.0377181819464873 8552 60 39 0.65 0.00456033676333021
TF TF:M07347 Factor: AhR; motif: NNNKNGCGTGNSNNNNN 0.0382953601572895 1426 49 11 0.224489795918367 0.00771388499298738
TF TF:M11849_1 Factor: MR; motif: NGNACRNNNYGTNCN; match class: 1 0.0382953601572895 4264 65 26 0.4 0.00609756097560976
TF TF:M04516_1 Factor: E2F-1; motif: TTTGGCGCCAAA; match class: 1 0.0398229728640531 10227 46 35 0.760869565217391 0.00342231348391513
TF TF:M08936 Factor: C-JUN:FOSB; motif: NATGACTCAY 0.039858037979536 3271 96 29 0.302083333333333 0.00886579027820238
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.0403214543259343 13022 77 64 0.831168831168831 0.00491475963753648
TF TF:M11090_1 Factor: TFEA; motif: YRCACGTGACN; match class: 1 0.0408416089426333 3393 64 22 0.34375 0.00648393751842028
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0408416089426333 9106 77 50 0.649350649350649 0.00549088513068307
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.0411867442334296 10055 58 42 0.724137931034483 0.00417702635504724
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 0.0411867442334296 12351 58 48 0.827586206896552 0.00388632499392762
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.0411867442334296 16194 60 58 0.966666666666667 0.00358157342225516
TF TF:M00924 Factor: AP-1; motif: TGACTCANNSKN 0.0419950199181707 2801 67 20 0.298507462686567 0.00714030703320243
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.0422396994597679 11063 60 46 0.766666666666667 0.00415800415800416
TF TF:M00444 Factor: VDR; motif: GGGKNARNRRGGWSA 0.0422396994597679 10308 65 47 0.723076923076923 0.00455956538610788
TF TF:M11849 Factor: MR; motif: NGNACRNNNYGTNCN 0.0422396994597679 4324 65 26 0.4 0.00601295097132285
TF TF:M03866 Factor: c-Fos:c-Jun; motif: NTGACTCAN 0.0426802653154482 1626 96 18 0.1875 0.011070110701107
TF TF:M00333_1 Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 0.0440707272472982 12401 58 48 0.827586206896552 0.00387065559229094
TF TF:M07259_1 Factor: HSF1; motif: TCYAGAANNTTC; match class: 1 0.0451713040696589 732 31 6 0.193548387096774 0.00819672131147541
TF TF:M12227_1 Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 0.0451713040696589 5898 60 30 0.5 0.00508646998982706
TF TF:M07226_1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 0.0453738762931259 3915 79 28 0.354430379746835 0.00715197956577267
TF TF:M10121 Factor: ZFX; motif: SNAGGCCNCR 0.0453738762931259 3997 15 9 0.6 0.00225168876657493
TF TF:M04453 Factor: AR; motif: RGGWACAYNGTGTWCYN 0.0459588713360499 7164 75 41 0.546666666666667 0.00572305974316025
TF TF:M11297 Factor: jdp2; motif: NRTGASTCAYN 0.046770028293846 1811 96 19 0.197916666666667 0.0104914411927112
TF TF:M11297_1 Factor: jdp2; motif: NRTGASTCAYN; match class: 1 0.046770028293846 1667 96 18 0.1875 0.0107978404319136
TF TF:M09658_1 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS; match class: 1 0.046770028293846 2033 79 18 0.227848101265823 0.0088539104771274
TF TF:M11081 Factor: SREBP-1; motif: RTCRCGTGAY 0.046770028293846 11062 12 12 1 0.00108479479298499
TF TF:M11054_1 Factor: Hey2; motif: NGCACGYGYN; match class: 1 0.046770028293846 808 63 9 0.142857142857143 0.0111386138613861
TF TF:M11846 Factor: GR; motif: RGWACATWAYGTWCY 0.046770028293846 6061 64 32 0.5 0.00527965682230655
TF TF:M01240_1 Factor: BEN; motif: CAGCGRNV; match class: 1 0.046770028293846 13227 57 49 0.859649122807018 0.00370454373629697
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.046770028293846 3962 40 17 0.425 0.00429076224129228
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.046770028293846 14473 67 60 0.895522388059702 0.00414565052166102
TF TF:M07042 Factor: HES-1; motif: NNCKYGTGNNN 0.046770028293846 3966 90 31 0.344444444444444 0.00781643973777105
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.046770028293846 14873 67 61 0.91044776119403 0.00410139178376925
TF TF:M04691 Factor: Kaiso; motif: TCTCGCGAG 0.046770028293846 15113 43 41 0.953488372093023 0.00271289618209489
TF TF:M00797_1 Factor: HIF1; motif: GNNKACGTGCGGNN; match class: 1 0.046770028293846 549 74 8 0.108108108108108 0.0145719489981785
TF TF:M10111 Factor: ZF5; motif: NGAGCGCGC 0.046770028293846 2647 57 17 0.298245614035088 0.00642236494144314
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.0471609808567007 3783 71 25 0.352112676056338 0.00660851176315094
TF TF:M11535_1 Factor: E2F-4; motif: TTTTGGCGCCAWWN; match class: 1 0.0471609808567007 6532 77 39 0.506493506493506 0.00597060624617269
TF TF:M07102_1 Factor: c-Jun; motif: NNNNRRTGASTCAN; match class: 1 0.0471609808567007 3047 96 27 0.28125 0.00886117492615688
TF TF:M12183 Factor: KLF14; motif: NRCCACRCCCMCN 0.0471609808567007 6878 14 11 0.785714285714286 0.00159930212271009
TF TF:M08938 Factor: C-JUN:FRA-1; motif: NNATGACTCATNN 0.048231618656288 3714 88 29 0.329545454545455 0.0078082929456112
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0483547840144628 5905 79 37 0.468354430379747 0.00626587637595258
TF TF:M08964_1 Factor: NR1B1:RXR-ALPHA; motif: RRGGTCANNNNNRGGTCA; match class: 1 0.0492785913281143 1827 96 19 0.197916666666667 0.0103995621237001
TF TF:M04106_1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 0.0494083054856018 8372 82 49 0.597560975609756 0.00585284280936455
TF TF:M11528_1 Factor: E2F-2; motif: NTTTTGGCGCCAWWWN; match class: 1 0.0496106817964005 4778 46 21 0.456521739130435 0.00439514441188782
TF TF:M07090_1 Factor: c-Fos; motif: NNTGASTCATN; match class: 1 0.0496106817964005 1726 94 18 0.191489361702128 0.0104287369640788
TF TF:M11056_1 Factor: Hey1; motif: NGCACGYGYN; match class: 1 0.0496106817964005 663 63 8 0.126984126984127 0.0120663650075415
WP WP:WP534 Glycolysis and Gluconeogenesis 2.46903068029545e-17 45 64 14 0.21875 0.311111111111111
WP WP:WP4629 Computational Model of Aerobic Glycolysis 2.46903068029545e-17 12 41 9 0.219512195121951 0.75
WP WP:WP1946 Cori Cycle 8.48559784344419e-15 17 48 9 0.1875 0.529411764705882
WP WP:WP4018 Pathways in clear cell renal cell carcinoma 1.08127974878709e-14 87 65 15 0.230769230769231 0.172413793103448
WP WP:WP4290 Metabolic reprogramming in colon cancer 1.60574196414336e-09 44 41 8 0.195121951219512 0.181818181818182
WP WP:WP5049 Glycolysis in senescence 3.12073098178864e-09 11 64 6 0.09375 0.545454545454545
WP WP:WP3614 Photodynamic therapy-induced HIF-1 survival signaling 4.55078807609963e-09 37 87 9 0.103448275862069 0.243243243243243
WP WP:WP2456 HIF1A and PPARG regulation of glycolysis 5.66766329564495e-08 8 4 3 0.75 0.375
WP WP:WP4206 Hereditary leiomyomatosis and renal cell carcinoma pathway 0.000840389542280451 20 81 4 0.0493827160493827 0.2
WP WP:WP3529 Zinc homeostasis 0.00265249818227777 37 59 4 0.0677966101694915 0.108108108108108
WP WP:WP3286 Copper homeostasis 0.01318709496949 54 28 3 0.107142857142857 0.0555555555555556
WP WP:WP500 Glycogen Synthesis and Degradation 0.0156343653899685 40 91 4 0.043956043956044 0.1
WP WP:WP4786 Type I collagen synthesis in the context of Osteogenesis imperfecta 0.0308920323324185 33 65 3 0.0461538461538462 0.0909090909090909

pM03 transcription factor target enrichment of top program genes

TF enrichment of pM03
TFs corrosponding to activation of pM03. (Left) pearson correlation of TF expression and gene expression program activatity in Myeloid cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.