pEpi28 program activity among Epithelial cells

Activation of pEpi28
pEpi28 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi28 by different cell subtypes
pEpi28 gene program activation among cells of different subtypes (Epithelial cells).

pEpi28 top program genes

Top genes of pEpi28 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi28 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi28
pEpi28 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:181 26S proteasome 1.13169444291589e-16 22 90 14 0.155555555555556 0.636363636363636
CORUM CORUM:193 PA700-20S-PA28 complex 1.13169444291589e-16 36 96 17 0.177083333333333 0.472222222222222
CORUM CORUM:178 Respiratory chain complex I (holoenzyme), mitochondrial 1.0980433323452e-14 44 69 15 0.217391304347826 0.340909090909091
CORUM CORUM:191 20S proteasome 3.54072768805869e-11 14 83 9 0.108433734939759 0.642857142857143
CORUM CORUM:194 PA28gamma-20S proteasome 6.951061084552e-11 15 83 9 0.108433734939759 0.6
CORUM CORUM:192 PA28-20S proteasome 1.29963054861693e-10 16 83 9 0.108433734939759 0.5625
CORUM CORUM:2905 Respiratory chain complex I (intermediate), mitochondrial 2.47437383152868e-08 11 52 6 0.115384615384615 0.545454545454545
CORUM CORUM:2948 Respiratory chain complex I (incomplete intermediate), mitochondrial 2.47437383152868e-08 11 52 6 0.115384615384615 0.545454545454545
CORUM CORUM:32 PA700 complex 1.35614476652957e-07 20 96 8 0.0833333333333333 0.4
CORUM CORUM:2914 Respiratory chain complex I (beta subunit) mitochondrial 3.00786710991042e-07 16 91 7 0.0769230769230769 0.4375
CORUM CORUM:2920 Respiratory chain complex I (lambda subunit) mitochondrial 3.00786710991042e-07 16 52 6 0.115384615384615 0.375
CORUM CORUM:2898 Respiratory chain complex I (intermediate I/200kD and III/250kD), mitochondrial 5.99066227542311e-07 3 18 3 0.166666666666667 1
CORUM CORUM:2904 Respiratory chain complex I (intermediate VII/650kD), mitochondrial 6.40310526386384e-07 10 52 5 0.0961538461538462 0.5
CORUM CORUM:2901 Respiratory chain complex I (intermediate IV/310kD), mitochondrial 2.04756529191437e-06 4 18 3 0.166666666666667 0.75
CORUM CORUM:2903 Respiratory chain complex I (intermediate V/380kD and VI/480kD), mitochondrial 4.76282086689657e-06 5 18 3 0.166666666666667 0.6
CORUM CORUM:2884 Respiratory chain complex I (early intermediate NDUFAF1 assembly), mitochondrial 3.35681908250299e-05 7 23 3 0.130434782608696 0.428571428571429
CORUM CORUM:2919 Respiratory chain complex I (gamma subunit) mitochondrial 0.00510526232907826 13 64 3 0.046875 0.230769230769231
GO:BP GO:0045333 cellular respiration 4.93926977982539e-34 192 91 30 0.32967032967033 0.15625
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 8.76618820757913e-29 289 91 30 0.32967032967033 0.103806228373702
GO:BP GO:0055114 obsolete oxidation-reduction process 1.24227507898363e-28 745 71 36 0.507042253521127 0.0483221476510067
GO:BP GO:0022900 electron transport chain 1.24227507898363e-28 180 91 26 0.285714285714286 0.144444444444444
GO:BP GO:0022904 respiratory electron transport chain 1.26965689463133e-26 117 91 22 0.241758241758242 0.188034188034188
GO:BP GO:0006091 generation of precursor metabolites and energy 2.58179915121832e-26 538 91 34 0.373626373626374 0.0631970260223048
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 7.89121938625768e-25 99 91 20 0.21978021978022 0.202020202020202
GO:BP GO:0042773 ATP synthesis coupled electron transport 8.59865890448357e-25 100 91 20 0.21978021978022 0.2
GO:BP GO:0019752 carboxylic acid metabolic process 3.23181740274673e-23 1024 84 38 0.452380952380952 0.037109375
GO:BP GO:0006521 regulation of cellular amino acid metabolic process 8.13450086593042e-23 64 96 17 0.177083333333333 0.265625
GO:BP GO:0043436 oxoacid metabolic process 8.27465799898314e-23 1057 84 38 0.452380952380952 0.0359508041627247
GO:BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 1.89178367046149e-22 56 91 16 0.175824175824176 0.285714285714286
GO:BP GO:0006082 organic acid metabolic process 2.10817509465688e-22 1090 84 38 0.452380952380952 0.0348623853211009
GO:BP GO:1902036 regulation of hematopoietic stem cell differentiation 1.11469653192737e-21 75 96 17 0.177083333333333 0.226666666666667
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 1.11469653192737e-21 75 96 17 0.177083333333333 0.226666666666667
GO:BP GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 2.18172200912157e-21 78 96 17 0.177083333333333 0.217948717948718
GO:BP GO:0010257 NADH dehydrogenase complex assembly 2.46866301802102e-21 67 69 15 0.217391304347826 0.223880597014925
GO:BP GO:0006119 oxidative phosphorylation 2.46866301802102e-21 151 91 20 0.21978021978022 0.132450331125828
GO:BP GO:0032981 mitochondrial respiratory chain complex I assembly 2.46866301802102e-21 67 69 15 0.217391304347826 0.223880597014925
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 2.80077138962718e-21 80 96 17 0.177083333333333 0.2125
GO:BP GO:0033238 regulation of cellular amine metabolic process 4.22373869748747e-21 82 96 17 0.177083333333333 0.207317073170732
GO:BP GO:0031145 anaphase-promoting complex-dependent catabolic process 7.84777403257312e-21 85 96 17 0.177083333333333 0.2
GO:BP GO:0060218 hematopoietic stem cell differentiation 1.67924831023539e-20 89 96 17 0.177083333333333 0.191011235955056
GO:BP GO:1901532 regulation of hematopoietic progenitor cell differentiation 1.67924831023539e-20 89 96 17 0.177083333333333 0.191011235955056
GO:BP GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 5.32086555531622e-20 95 96 17 0.177083333333333 0.178947368421053
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1.08302628298724e-19 99 96 17 0.177083333333333 0.171717171717172
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 1.79058277543214e-19 102 96 17 0.177083333333333 0.166666666666667
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 2.91312800914656e-19 105 96 17 0.177083333333333 0.161904761904762
GO:BP GO:0060071 Wnt signaling pathway, planar cell polarity pathway 6.48792769229799e-19 110 96 17 0.177083333333333 0.154545454545455
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 7.37526039472653e-19 111 96 17 0.177083333333333 0.153153153153153
GO:BP GO:0002223 stimulatory C-type lectin receptor signaling pathway 8.37974407569243e-19 112 96 17 0.177083333333333 0.151785714285714
GO:BP GO:1902750 negative regulation of cell cycle G2/M phase transition 9.51588158704863e-19 113 96 17 0.177083333333333 0.150442477876106
GO:BP GO:0090175 regulation of establishment of planar polarity 1.07998435035255e-18 114 96 17 0.177083333333333 0.149122807017544
GO:BP GO:2000736 regulation of stem cell differentiation 1.189965388898e-18 115 96 17 0.177083333333333 0.147826086956522
GO:BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 1.189965388898e-18 115 96 17 0.177083333333333 0.147826086956522
GO:BP GO:0002758 innate immune response-activating signal transduction 1.34996281156712e-18 116 96 17 0.177083333333333 0.146551724137931
GO:BP GO:0033108 mitochondrial respiratory chain complex assembly 1.35288739348117e-18 103 69 15 0.217391304347826 0.145631067961165
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 1.4901350744776e-18 117 96 17 0.177083333333333 0.145299145299145
GO:BP GO:0044281 small molecule metabolic process 5.87582704433133e-18 1921 84 42 0.5 0.0218636127017179
GO:BP GO:0007164 establishment of tissue polarity 8.91626415058655e-18 130 96 17 0.177083333333333 0.130769230769231
GO:BP GO:0001736 establishment of planar polarity 8.91626415058655e-18 130 96 17 0.177083333333333 0.130769230769231
GO:BP GO:0002218 activation of innate immune response 5.14804002888902e-17 144 96 17 0.177083333333333 0.118055555555556
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 5.14804002888902e-17 174 96 18 0.1875 0.103448275862069
GO:BP GO:0006099 tricarboxylic acid cycle 1.02775542633422e-16 36 79 11 0.139240506329114 0.305555555555556
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 1.06678945191686e-16 182 96 18 0.1875 0.0989010989010989
GO:BP GO:0035567 non-canonical Wnt signaling pathway 1.06678945191686e-16 151 96 17 0.177083333333333 0.112582781456954
GO:BP GO:0090263 positive regulation of canonical Wnt signaling pathway 1.06678945191686e-16 151 96 17 0.177083333333333 0.112582781456954
GO:BP GO:0001738 morphogenesis of a polarized epithelium 1.16895125973769e-16 152 96 17 0.177083333333333 0.111842105263158
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 2.69475834632298e-16 192 96 18 0.1875 0.09375
GO:BP GO:0043488 regulation of mRNA stability 2.92394487402953e-16 191 97 18 0.185567010309278 0.0942408376963351
GO:BP GO:0042180 cellular ketone metabolic process 3.6663645260402e-16 271 96 20 0.208333333333333 0.0738007380073801
GO:BP GO:0044106 cellular amine metabolic process 3.6663645260402e-16 163 96 17 0.177083333333333 0.104294478527607
GO:BP GO:0038095 Fc-epsilon receptor signaling pathway 5.37106964987036e-16 167 96 17 0.177083333333333 0.101796407185629
GO:BP GO:0009308 amine metabolic process 5.84077819397089e-16 168 96 17 0.177083333333333 0.101190476190476
GO:BP GO:0043487 regulation of RNA stability 6.66487265416072e-16 201 97 18 0.185567010309278 0.0895522388059701
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 8.43199683581861e-16 172 96 17 0.177083333333333 0.0988372093023256
GO:BP GO:0071456 cellular response to hypoxia 1.3513889474267e-15 212 96 18 0.1875 0.0849056603773585
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 1.3513889474267e-15 177 96 17 0.177083333333333 0.096045197740113
GO:BP GO:0061013 regulation of mRNA catabolic process 1.75627113097349e-15 213 97 18 0.185567010309278 0.0845070422535211
GO:BP GO:0006520 cellular amino acid metabolic process 1.79901550340698e-15 341 96 21 0.21875 0.06158357771261
GO:BP GO:0046034 ATP metabolic process 1.80431591474147e-15 314 91 20 0.21978021978022 0.0636942675159236
GO:BP GO:0030177 positive regulation of Wnt signaling pathway 2.37093353956982e-15 184 96 17 0.177083333333333 0.0923913043478261
GO:BP GO:2000027 regulation of animal organ morphogenesis 2.37093353956982e-15 184 96 17 0.177083333333333 0.0923913043478261
GO:BP GO:0071347 cellular response to interleukin-1 2.55939135593267e-15 185 96 17 0.177083333333333 0.0918918918918919
GO:BP GO:0036294 cellular response to decreased oxygen levels 2.7454779997936e-15 222 96 18 0.1875 0.0810810810810811
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 2.97975148692686e-15 187 96 17 0.177083333333333 0.0909090909090909
GO:BP GO:0010565 regulation of cellular ketone metabolic process 5.39504667257656e-15 194 96 17 0.177083333333333 0.0876288659793814
GO:BP GO:0038061 NIK/NF-kappaB signaling 5.39504667257656e-15 194 96 17 0.177083333333333 0.0876288659793814
GO:BP GO:0019882 antigen processing and presentation 6.59012350418958e-15 234 96 18 0.1875 0.0769230769230769
GO:BP GO:0038093 Fc receptor signaling pathway 8.76993607042661e-15 238 96 18 0.1875 0.0756302521008403
GO:BP GO:0010499 proteasomal ubiquitin-independent protein catabolic process 9.72331702479635e-15 23 83 9 0.108433734939759 0.391304347826087
GO:BP GO:0071453 cellular response to oxygen levels 9.88644766636458e-15 240 96 18 0.1875 0.075
GO:BP GO:0050852 T cell receptor signaling pathway 1.08148543904267e-14 203 96 17 0.177083333333333 0.083743842364532
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 1.48214267322784e-14 207 96 17 0.177083333333333 0.0821256038647343
GO:BP GO:0070555 response to interleukin-1 2.76543451694221e-14 215 96 17 0.177083333333333 0.0790697674418605
GO:BP GO:0045089 positive regulation of innate immune response 2.94987666669249e-14 216 96 17 0.177083333333333 0.0787037037037037
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 3.39782461663915e-14 218 96 17 0.177083333333333 0.0779816513761468
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 4.27394820579181e-14 262 96 18 0.1875 0.0687022900763359
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 4.83995997714168e-14 223 96 17 0.177083333333333 0.0762331838565022
GO:BP GO:0009060 aerobic respiration 7.02326470342624e-14 89 79 12 0.151898734177215 0.134831460674157
GO:BP GO:1901988 negative regulation of cell cycle phase transition 1.39812334905652e-13 281 96 18 0.1875 0.0640569395017794
GO:BP GO:0044237 cellular metabolic process 3.09885539903338e-13 10871 98 92 0.938775510204082 0.00846288289945727
GO:BP GO:0002833 positive regulation of response to biotic stimulus 3.09885539903338e-13 250 96 17 0.177083333333333 0.068
GO:BP GO:0048863 stem cell differentiation 5.11539580151566e-13 258 96 17 0.177083333333333 0.0658914728682171
GO:BP GO:0070646 protein modification by small protein removal 7.30023347060432e-13 310 96 18 0.1875 0.0580645161290323
GO:BP GO:1903311 regulation of mRNA metabolic process 7.32849653332263e-13 356 97 19 0.195876288659794 0.0533707865168539
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 7.67221946076109e-13 265 96 17 0.177083333333333 0.0641509433962264
GO:BP GO:0010948 negative regulation of cell cycle process 1.29303241595732e-12 372 96 19 0.197916666666667 0.0510752688172043
GO:BP GO:0044839 cell cycle G2/M phase transition 2.19987623978988e-12 283 96 17 0.177083333333333 0.0600706713780919
GO:BP GO:0045930 negative regulation of mitotic cell cycle 2.35501513444201e-12 333 96 18 0.1875 0.0540540540540541
GO:BP GO:0006402 mRNA catabolic process 2.64400631875828e-12 384 97 19 0.195876288659794 0.0494791666666667
GO:BP GO:1901685 glutathione derivative metabolic process 2.64400631875828e-12 21 54 7 0.12962962962963 0.333333333333333
GO:BP GO:1901687 glutathione derivative biosynthetic process 2.64400631875828e-12 21 54 7 0.12962962962963 0.333333333333333
GO:BP GO:0016579 protein deubiquitination 3.46875618807479e-12 292 96 17 0.177083333333333 0.0582191780821918
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 4.77635894884115e-12 298 96 17 0.177083333333333 0.0570469798657718
GO:BP GO:0007005 mitochondrion organization 6.71689666737738e-12 561 91 21 0.230769230769231 0.0374331550802139
GO:BP GO:0071356 cellular response to tumor necrosis factor 7.1862829987678e-12 306 96 17 0.177083333333333 0.0555555555555556
GO:BP GO:0045088 regulation of innate immune response 8.32877243243666e-12 309 96 17 0.177083333333333 0.0550161812297735
GO:BP GO:0031349 positive regulation of defense response 8.77650047152747e-12 362 96 18 0.1875 0.0497237569060773
GO:BP GO:0043687 post-translational protein modification 8.77650047152747e-12 362 96 18 0.1875 0.0497237569060773
GO:BP GO:0001666 response to hypoxia 1.09599781554695e-11 367 96 18 0.1875 0.0490463215258856
GO:BP GO:0006401 RNA catabolic process 1.39580298051113e-11 424 97 19 0.195876288659794 0.044811320754717
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 1.61918457945634e-11 323 96 17 0.177083333333333 0.0526315789473684
GO:BP GO:0036293 response to decreased oxygen levels 2.09194619782989e-11 382 96 18 0.1875 0.0471204188481675
GO:BP GO:0034612 response to tumor necrosis factor 2.35302655834431e-11 331 96 17 0.177083333333333 0.0513595166163142
GO:BP GO:0000209 protein polyubiquitination 3.933995261566e-11 342 96 17 0.177083333333333 0.0497076023391813
GO:BP GO:0060070 canonical Wnt signaling pathway 4.48062145596178e-11 345 96 17 0.177083333333333 0.0492753623188406
GO:BP GO:0070482 response to oxygen levels 6.07327596759876e-11 408 96 18 0.1875 0.0441176470588235
GO:BP GO:0002831 regulation of response to biotic stimulus 7.99087927222431e-11 415 96 18 0.1875 0.0433734939759036
GO:BP GO:0030111 regulation of Wnt signaling pathway 1.70925111848151e-10 376 96 17 0.177083333333333 0.0452127659574468
GO:BP GO:0008152 metabolic process 2.44770692799625e-10 11827 98 92 0.938775510204082 0.00777881119472394
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 3.08468944812502e-10 451 96 18 0.1875 0.0399113082039911
GO:BP GO:0034622 cellular protein-containing complex assembly 4.28468754673565e-10 1107 93 26 0.279569892473118 0.023486901535682
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 7.53516967342306e-10 477 96 18 0.1875 0.0377358490566038
GO:BP GO:0002757 immune response-activating signal transduction 7.53516967342306e-10 477 96 18 0.1875 0.0377358490566038
GO:BP GO:1901987 regulation of cell cycle phase transition 1.27912781664386e-09 493 96 18 0.1875 0.0365111561866126
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 1.51745845137378e-09 434 96 17 0.177083333333333 0.0391705069124424
GO:BP GO:0034655 nucleobase-containing compound catabolic process 1.84125226594972e-09 567 97 19 0.195876288659794 0.0335097001763668
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 2.30218815881001e-09 512 96 18 0.1875 0.03515625
GO:BP GO:0062012 regulation of small molecule metabolic process 2.33550407439081e-09 447 96 17 0.177083333333333 0.0380313199105145
GO:BP GO:0032103 positive regulation of response to external stimulus 2.33669646171565e-09 513 96 18 0.1875 0.0350877192982456
GO:BP GO:1990748 cellular detoxification 2.36925388349806e-09 113 63 9 0.142857142857143 0.079646017699115
GO:BP GO:0002764 immune response-regulating signaling pathway 2.44787979684836e-09 515 96 18 0.1875 0.0349514563106796
GO:BP GO:0043933 protein-containing complex subunit organization 3.20737529214533e-09 1963 93 33 0.354838709677419 0.0168110035659705
GO:BP GO:0016055 Wnt signaling pathway 3.71166641607521e-09 529 96 18 0.1875 0.0340264650283554
GO:BP GO:0198738 cell-cell signaling by wnt 3.91191963153386e-09 531 96 18 0.1875 0.0338983050847458
GO:BP GO:0097237 cellular response to toxic substance 3.91191963153386e-09 120 63 9 0.142857142857143 0.075
GO:BP GO:0044772 mitotic cell cycle phase transition 4.6517212006855e-09 609 96 19 0.197916666666667 0.0311986863711002
GO:BP GO:0046700 heterocycle catabolic process 4.6517212006855e-09 602 97 19 0.195876288659794 0.0315614617940199
GO:BP GO:0044270 cellular nitrogen compound catabolic process 5.41221289577931e-09 608 97 19 0.195876288659794 0.03125
GO:BP GO:0019439 aromatic compound catabolic process 8.06789778881961e-09 623 97 19 0.195876288659794 0.0304975922953451
GO:BP GO:0010498 proteasomal protein catabolic process 8.95287598791747e-09 491 96 17 0.177083333333333 0.0346232179226069
GO:BP GO:0098754 detoxification 1.00351690047992e-08 134 63 9 0.142857142857143 0.0671641791044776
GO:BP GO:0002253 activation of immune response 1.08013489517202e-08 568 96 18 0.1875 0.0316901408450704
GO:BP GO:0045786 negative regulation of cell cycle 1.21922498245705e-08 647 96 19 0.197916666666667 0.0293663060278207
GO:BP GO:0044770 cell cycle phase transition 1.59986736764092e-08 658 96 19 0.197916666666667 0.0288753799392097
GO:BP GO:1901361 organic cyclic compound catabolic process 1.60003315123484e-08 651 97 19 0.195876288659794 0.0291858678955453
GO:BP GO:0044272 sulfur compound biosynthetic process 3.8513670877286e-08 193 70 10 0.142857142857143 0.0518134715025907
GO:BP GO:0007346 regulation of mitotic cell cycle 4.04434475931418e-08 619 96 18 0.1875 0.0290791599353796
GO:BP GO:0002009 morphogenesis of an epithelium 6.08722517038161e-08 560 96 17 0.177083333333333 0.0303571428571429
GO:BP GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 6.08722517038161e-08 636 96 18 0.1875 0.0283018867924528
GO:BP GO:0098869 cellular oxidant detoxification 7.21699900968862e-08 100 27 6 0.222222222222222 0.06
GO:BP GO:0065003 protein-containing complex assembly 1.24774298778719e-07 1680 93 28 0.301075268817204 0.0166666666666667
GO:BP GO:0031347 regulation of defense response 2.8552851704688e-07 704 96 18 0.1875 0.0255681818181818
GO:BP GO:0044248 cellular catabolic process 3.07771139919038e-07 2347 98 34 0.346938775510204 0.0144865786109928
GO:BP GO:0016071 mRNA metabolic process 3.23176645604912e-07 874 97 20 0.206185567010309 0.022883295194508
GO:BP GO:0010564 regulation of cell cycle process 4.1971059922854e-07 809 96 19 0.197916666666667 0.0234857849196539
GO:BP GO:0019221 cytokine-mediated signaling pathway 4.25106084545097e-07 810 96 19 0.197916666666667 0.0234567901234568
GO:BP GO:1903047 mitotic cell cycle process 5.21666264785841e-07 911 96 20 0.208333333333333 0.021953896816685
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 5.68089731733157e-07 655 96 17 0.177083333333333 0.0259541984732824
GO:BP GO:0019941 modification-dependent protein catabolic process 6.57840655817189e-07 662 96 17 0.177083333333333 0.0256797583081571
GO:BP GO:0048729 tissue morphogenesis 7.2827771475204e-07 667 96 17 0.177083333333333 0.0254872563718141
GO:BP GO:0050778 positive regulation of immune response 7.44787046820445e-07 753 96 18 0.1875 0.0239043824701195
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 8.17539488432198e-07 673 96 17 0.177083333333333 0.025260029717682
GO:BP GO:0031329 regulation of cellular catabolic process 1.37808954477363e-06 866 97 19 0.195876288659794 0.0219399538106236
GO:BP GO:0009636 response to toxic substance 1.53168376428967e-06 243 63 9 0.142857142857143 0.037037037037037
GO:BP GO:0010608 posttranscriptional regulation of gene expression 2.30291801573165e-06 896 97 19 0.195876288659794 0.0212053571428571
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 3.70292172143546e-06 750 96 17 0.177083333333333 0.0226666666666667
GO:BP GO:0009056 catabolic process 3.93157487353795e-06 2744 98 35 0.357142857142857 0.0127551020408163
GO:BP GO:0032101 regulation of response to external stimulus 4.86008957836043e-06 1051 96 20 0.208333333333333 0.0190294957183635
GO:BP GO:0000278 mitotic cell cycle 5.4432998807584e-06 1059 96 20 0.208333333333333 0.0188857412653447
GO:BP GO:0016567 protein ubiquitination 8.52235074883294e-06 892 96 18 0.1875 0.0201793721973094
GO:BP GO:0044257 cellular protein catabolic process 1.09757159573425e-05 813 96 17 0.177083333333333 0.020910209102091
GO:BP GO:1901575 organic substance catabolic process 1.35210892580863e-05 2267 97 30 0.309278350515464 0.0132333480370534
GO:BP GO:0030097 hemopoiesis 1.4743457163614e-05 928 96 18 0.1875 0.0193965517241379
GO:BP GO:0000165 MAPK cascade 1.63071689646893e-05 935 96 18 0.1875 0.0192513368983957
GO:BP GO:0006790 sulfur compound metabolic process 1.76070167479852e-05 386 54 9 0.166666666666667 0.0233160621761658
GO:BP GO:0009894 regulation of catabolic process 1.83853738146141e-05 1033 97 19 0.195876288659794 0.0183930300096805
GO:BP GO:0110095 cellular detoxification of aldehyde 2.05253653252251e-05 8 63 3 0.0476190476190476 0.375
GO:BP GO:0048534 hematopoietic or lymphoid organ development 2.52479442917644e-05 966 96 18 0.1875 0.0186335403726708
GO:BP GO:0032446 protein modification by small protein conjugation 2.77792449006926e-05 973 96 18 0.1875 0.0184994861253854
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 2.92647024260013e-05 2255 96 29 0.302083333333333 0.012860310421286
GO:BP GO:0006108 malate metabolic process 3.26561851561311e-05 8 74 3 0.0405405405405405 0.375
GO:BP GO:0050776 regulation of immune response 3.78429730038242e-05 996 96 18 0.1875 0.0180722891566265
GO:BP GO:0070125 mitochondrial translational elongation 3.88978200122315e-05 87 89 6 0.0674157303370786 0.0689655172413793
GO:BP GO:0010033 response to organic substance 4.48358266613144e-05 3412 39 20 0.512820512820513 0.00586166471277843
GO:BP GO:0002520 immune system development 5.175939332147e-05 1020 96 18 0.1875 0.0176470588235294
GO:BP GO:0071345 cellular response to cytokine stimulus 5.59782854369811e-05 1132 96 19 0.197916666666667 0.0167844522968198
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 6.86562846455176e-05 1042 96 18 0.1875 0.017274472168906
GO:BP GO:0019395 fatty acid oxidation 8.22507100390226e-05 108 82 6 0.0731707317073171 0.0555555555555556
GO:BP GO:0002684 positive regulation of immune system process 9.14966954628138e-05 1065 96 18 0.1875 0.0169014084507042
GO:BP GO:0046185 aldehyde catabolic process 9.56110127787239e-05 13 63 3 0.0476190476190476 0.230769230769231
GO:BP GO:0110096 cellular response to aldehyde 9.56110127787239e-05 13 63 3 0.0476190476190476 0.230769230769231
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.000102664131354448 1184 96 19 0.197916666666667 0.0160472972972973
GO:BP GO:0034440 lipid oxidation 0.000103783839728065 113 82 6 0.0731707317073171 0.0530973451327434
GO:BP GO:0030163 protein catabolic process 0.000107396735687453 974 96 17 0.177083333333333 0.0174537987679671
GO:BP GO:0072329 monocarboxylic acid catabolic process 0.000122749695383177 132 43 5 0.116279069767442 0.0378787878787879
GO:BP GO:0045087 innate immune response 0.00014552817590207 998 96 17 0.177083333333333 0.0170340681362725
GO:BP GO:0042221 response to chemical 0.000145746962073084 4781 39 23 0.58974358974359 0.0048107090566827
GO:BP GO:0140053 mitochondrial gene expression 0.000150004733222423 167 89 7 0.0786516853932584 0.0419161676646707
GO:BP GO:0044283 small molecule biosynthetic process 0.000151508482786018 704 50 10 0.2 0.0142045454545455
GO:BP GO:0034097 response to cytokine 0.000160436800322821 1226 96 19 0.197916666666667 0.0154975530179445
GO:BP GO:0043603 cellular amide metabolic process 0.000161836903647281 1241 95 19 0.2 0.0153102336825141
GO:BP GO:0051726 regulation of cell cycle 0.000177777056359479 1236 96 19 0.197916666666667 0.0153721682847896
GO:BP GO:0060429 epithelium development 0.000185017582380123 1325 98 20 0.204081632653061 0.0150943396226415
GO:BP GO:0006635 fatty acid beta-oxidation 0.000186064846868399 76 40 4 0.1 0.0526315789473684
GO:BP GO:0080134 regulation of response to stress 0.000189708445698654 1443 38 12 0.315789473684211 0.00831600831600832
GO:BP GO:0044265 cellular macromolecule catabolic process 0.000191890835720464 1231 97 19 0.195876288659794 0.0154346060113729
GO:BP GO:0009968 negative regulation of signal transduction 0.000199472508085027 1364 96 20 0.208333333333333 0.0146627565982405
GO:BP GO:0043604 amide biosynthetic process 0.000199472508085027 932 95 16 0.168421052631579 0.0171673819742489
GO:BP GO:0044282 small molecule catabolic process 0.000220987074727937 439 82 10 0.121951219512195 0.0227790432801822
GO:BP GO:0009628 response to abiotic stimulus 0.00022521606099569 1261 96 19 0.197916666666667 0.0150674068199841
GO:BP GO:0006805 xenobiotic metabolic process 0.000234894604958551 122 27 4 0.148148148148148 0.0327868852459016
GO:BP GO:0071466 cellular response to xenobiotic stimulus 0.000272295241603124 127 27 4 0.148148148148148 0.031496062992126
GO:BP GO:0009410 response to xenobiotic stimulus 0.000332681327222753 134 27 4 0.148148148148148 0.0298507462686567
GO:BP GO:0009887 animal organ morphogenesis 0.000332681327222753 1073 96 17 0.177083333333333 0.0158434296365331
GO:BP GO:0005996 monosaccharide metabolic process 0.000386722646763532 276 44 6 0.136363636363636 0.0217391304347826
GO:BP GO:0043648 dicarboxylic acid metabolic process 0.000393854883588982 99 74 5 0.0675675675675676 0.0505050505050505
GO:BP GO:0022402 cell cycle process 0.000406134445872299 1439 96 20 0.208333333333333 0.0138985406532314
GO:BP GO:0032543 mitochondrial translation 0.000412355580624293 136 89 6 0.0674157303370786 0.0441176470588235
GO:BP GO:0006518 peptide metabolic process 0.000433787659339064 955 89 15 0.168539325842697 0.0157068062827225
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.000433787659339064 3087 71 26 0.366197183098592 0.00842241658568189
GO:BP GO:0051707 response to other organism 0.000457643230846862 1592 38 12 0.315789473684211 0.00753768844221105
GO:BP GO:0043207 response to external biotic stimulus 0.000461162414603664 1594 38 12 0.315789473684211 0.00752823086574655
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.000473822567986087 1853 95 23 0.242105263157895 0.0124123043712898
GO:BP GO:0006414 translational elongation 0.000488075833364371 141 89 6 0.0674157303370786 0.0425531914893617
GO:BP GO:0006793 phosphorus metabolic process 0.000490928623470572 3114 71 26 0.366197183098592 0.00834938985228003
GO:BP GO:0006081 cellular aldehyde metabolic process 0.000506279657438812 64 63 4 0.0634920634920635 0.0625
GO:BP GO:0010648 negative regulation of cell communication 0.000506279657438812 1468 96 20 0.208333333333333 0.0136239782016349
GO:BP GO:0070126 mitochondrial translational termination 0.000507223371883618 88 89 5 0.0561797752808989 0.0568181818181818
GO:BP GO:0002682 regulation of immune system process 0.000511520233204412 1617 38 12 0.315789473684211 0.00742115027829314
GO:BP GO:0023057 negative regulation of signaling 0.000512890719350749 1471 96 20 0.208333333333333 0.0135961930659415
GO:BP GO:0009607 response to biotic stimulus 0.000535167425885057 1626 38 12 0.315789473684211 0.00738007380073801
GO:BP GO:1901565 organonitrogen compound catabolic process 0.000544840920061433 1358 96 19 0.197916666666667 0.0139911634756996
GO:BP GO:0046364 monosaccharide biosynthetic process 0.000577469662067208 98 43 4 0.0930232558139535 0.0408163265306122
GO:BP GO:0016032 viral process 0.000580600588068764 942 93 15 0.161290322580645 0.0159235668789809
GO:BP GO:1901576 organic substance biosynthetic process 0.000599618655168152 6248 57 34 0.596491228070175 0.00544174135723431
GO:BP GO:0009062 fatty acid catabolic process 0.000601911149321053 107 40 4 0.1 0.0373831775700935
GO:BP GO:0010629 negative regulation of gene expression 0.000607432093679029 1460 98 20 0.204081632653061 0.0136986301369863
GO:BP GO:0006749 glutathione metabolic process 0.000738601633619958 63 27 3 0.111111111111111 0.0476190476190476
GO:BP GO:0046395 carboxylic acid catabolic process 0.000811446748214958 245 82 7 0.0853658536585366 0.0285714285714286
GO:BP GO:0009058 biosynthetic process 0.00081643263663133 6340 57 34 0.596491228070175 0.00536277602523659
GO:BP GO:0048585 negative regulation of response to stimulus 0.00094797918471413 1733 38 12 0.315789473684211 0.00692440854010387
GO:BP GO:0044242 cellular lipid catabolic process 0.000981894509290141 232 40 5 0.125 0.021551724137931
GO:BP GO:0022607 cellular component assembly 0.000993450611880677 3010 93 30 0.32258064516129 0.00996677740863787
GO:BP GO:0006415 translational termination 0.00103629897719016 104 89 5 0.0561797752808989 0.0480769230769231
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.00107146518180706 1001 93 15 0.161290322580645 0.014985014985015
GO:BP GO:0032787 monocarboxylic acid metabolic process 0.00114494539348583 658 82 11 0.134146341463415 0.0167173252279635
GO:BP GO:0016054 organic acid catabolic process 0.00117244462457194 262 82 7 0.0853658536585366 0.0267175572519084
GO:BP GO:0033554 cellular response to stress 0.00124827205218418 2111 90 23 0.255555555555556 0.0108953102794884
GO:BP GO:0098542 defense response to other organism 0.00130006227487418 1218 96 17 0.177083333333333 0.0139573070607553
GO:BP GO:0070887 cellular response to chemical stimulus 0.00132491685374362 3393 38 17 0.447368421052632 0.00501031535514294
GO:BP GO:0009057 macromolecule catabolic process 0.00158407372767343 1468 97 19 0.195876288659794 0.0129427792915531
GO:BP GO:0046394 carboxylic acid biosynthetic process 0.00175349734274251 330 50 6 0.12 0.0181818181818182
GO:BP GO:0016053 organic acid biosynthetic process 0.00196205158639186 338 50 6 0.12 0.0177514792899408
GO:BP GO:1901564 organonitrogen compound metabolic process 0.00220457868264588 6792 90 50 0.555555555555556 0.00736160188457008
GO:BP GO:0044085 cellular component biogenesis 0.00244399694230461 3257 95 31 0.326315789473684 0.00951796131409272
GO:BP GO:0016310 phosphorylation 0.00258487262192107 2138 71 19 0.267605633802817 0.00888681010289991
GO:BP GO:0006734 NADH metabolic process 0.00268256588929349 46 59 3 0.0508474576271186 0.0652173913043478
GO:BP GO:0043043 peptide biosynthetic process 0.00279662384079575 790 89 12 0.134831460674157 0.0151898734177215
GO:BP GO:0006631 fatty acid metabolic process 0.00284602429465033 404 82 8 0.0975609756097561 0.0198019801980198
GO:BP GO:0006508 proteolysis 0.00307787947616572 1836 83 19 0.228915662650602 0.0103485838779956
GO:BP GO:0002183 cytoplasmic translational initiation 0.00350631921619792 35 86 3 0.0348837209302326 0.0857142857142857
GO:BP GO:0007049 cell cycle 0.00477242997430889 1902 96 21 0.21875 0.0110410094637224
GO:BP GO:0006952 defense response 0.00530932049882979 1818 38 11 0.289473684210526 0.00605060506050605
GO:BP GO:0071310 cellular response to organic substance 0.00543013350506924 2776 38 14 0.368421052631579 0.00504322766570605
GO:BP GO:0016042 lipid catabolic process 0.00548806702456832 349 40 5 0.125 0.0143266475644699
GO:BP GO:0006979 response to oxidative stress 0.00556812135234565 466 18 4 0.222222222222222 0.00858369098712446
GO:BP GO:0071616 acyl-CoA biosynthetic process 0.00657977951530249 54 70 3 0.0428571428571429 0.0555555555555556
GO:BP GO:0035384 thioester biosynthetic process 0.00657977951530249 54 70 3 0.0428571428571429 0.0555555555555556
GO:BP GO:0044249 cellular biosynthetic process 0.00661123992358615 6154 57 31 0.543859649122807 0.00503737406564836
GO:BP GO:0006412 translation 0.00696489240068391 764 89 11 0.123595505617978 0.0143979057591623
GO:BP GO:0009967 positive regulation of signal transduction 0.0071674308104374 1598 38 10 0.263157894736842 0.00625782227784731
GO:BP GO:0006006 glucose metabolic process 0.0072733734784919 211 70 5 0.0714285714285714 0.023696682464455
GO:BP GO:0030258 lipid modification 0.00777043578707512 271 82 6 0.0731707317073171 0.022140221402214
GO:BP GO:0055085 transmembrane transport 0.00838652583757473 1635 38 10 0.263157894736842 0.00611620795107034
GO:BP GO:0016051 carbohydrate biosynthetic process 0.00869855242505253 214 43 4 0.0930232558139535 0.0186915887850467
GO:BP GO:0005975 carbohydrate metabolic process 0.00886237808613642 635 94 10 0.106382978723404 0.015748031496063
GO:BP GO:0009888 tissue development 0.00904893221825311 2107 98 22 0.224489795918367 0.0104413858566682
GO:BP GO:0009605 response to external stimulus 0.00910845128820376 2944 38 14 0.368421052631579 0.0047554347826087
GO:BP GO:0045595 regulation of cell differentiation 0.00994264297442325 1679 38 10 0.263157894736842 0.00595592614651578
GO:BP GO:0006955 immune response 0.010271283449769 2311 38 12 0.315789473684211 0.00519255733448724
GO:BP GO:0048584 positive regulation of response to stimulus 0.0115312047913444 2344 38 12 0.315789473684211 0.00511945392491468
GO:BP GO:0034033 purine nucleoside bisphosphate biosynthetic process 0.0116562095858906 68 70 3 0.0428571428571429 0.0441176470588235
GO:BP GO:0034030 ribonucleoside bisphosphate biosynthetic process 0.0116562095858906 68 70 3 0.0428571428571429 0.0441176470588235
GO:BP GO:0033866 nucleoside bisphosphate biosynthetic process 0.0116562095858906 68 70 3 0.0428571428571429 0.0441176470588235
GO:BP GO:0006996 organelle organization 0.0141555002188403 4104 55 22 0.4 0.00536062378167641
GO:BP GO:0010647 positive regulation of cell communication 0.0141745943842862 1777 38 10 0.263157894736842 0.0056274620146314
GO:BP GO:0019318 hexose metabolic process 0.0143061590829381 253 70 5 0.0714285714285714 0.0197628458498024
GO:BP GO:0023056 positive regulation of signaling 0.0143370827586906 1782 38 10 0.263157894736842 0.00561167227833894
GO:BP GO:0006575 cellular modified amino acid metabolic process 0.0149558271687624 199 27 3 0.111111111111111 0.0150753768844221
GO:BP GO:0043312 neutrophil degranulation 0.0150605961243795 482 38 5 0.131578947368421 0.0103734439834025
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0153272022421302 485 38 5 0.131578947368421 0.0103092783505155
GO:BP GO:0045055 regulated exocytosis 0.0153272022421302 785 15 4 0.266666666666667 0.00509554140127389
GO:BP GO:0002446 neutrophil mediated immunity 0.0167141525187637 497 38 5 0.131578947368421 0.0100603621730382
GO:BP GO:0042119 neutrophil activation 0.0167591753959513 498 38 5 0.131578947368421 0.0100401606425703
GO:BP GO:0050896 response to stimulus 0.0169894769135249 9407 22 18 0.818181818181818 0.0019134686935261
GO:BP GO:0007267 cell-cell signaling 0.0172450561165008 1722 96 18 0.1875 0.0104529616724739
GO:BP GO:0036230 granulocyte activation 0.017482452251152 504 38 5 0.131578947368421 0.00992063492063492
GO:BP GO:0035556 intracellular signal transduction 0.0179862696318531 2772 39 13 0.333333333333333 0.00468975468975469
GO:BP GO:0034308 primary alcohol metabolic process 0.0194773839694209 95 63 3 0.0476190476190476 0.0315789473684211
GO:BP GO:0006887 exocytosis 0.0194773839694209 904 42 7 0.166666666666667 0.00774336283185841
GO:BP GO:0002376 immune system process 0.0209322849542879 3278 38 14 0.368421052631579 0.00427089688834655
GO:BP GO:0043299 leukocyte degranulation 0.0212685563786805 535 38 5 0.131578947368421 0.00934579439252336
GO:BP GO:0043624 cellular protein complex disassembly 0.0216718586808029 226 89 5 0.0561797752808989 0.0221238938053097
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0224793397241681 547 38 5 0.131578947368421 0.00914076782449726
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0229928559885021 551 38 5 0.131578947368421 0.00907441016333938
GO:BP GO:0001775 cell activation 0.0231612527785146 1495 15 5 0.333333333333333 0.00334448160535117
GO:BP GO:0032984 protein-containing complex disassembly 0.0241464283919325 333 89 6 0.0674157303370786 0.018018018018018
GO:BP GO:0010243 response to organonitrogen compound 0.024879848928409 1085 7 3 0.428571428571429 0.00276497695852535
GO:BP GO:0044238 primary metabolic process 0.025693194297789 10584 97 69 0.711340206185567 0.00651927437641723
GO:BP GO:0006810 transport 0.0289433939839813 5224 42 20 0.476190476190476 0.00382848392036753
GO:BP GO:0035383 thioester metabolic process 0.0293454058455227 105 70 3 0.0428571428571429 0.0285714285714286
GO:BP GO:1901698 response to nitrogen compound 0.0293454058455227 1172 7 3 0.428571428571429 0.00255972696245734
GO:BP GO:0006637 acyl-CoA metabolic process 0.0293454058455227 105 70 3 0.0428571428571429 0.0285714285714286
GO:BP GO:0071704 organic substance metabolic process 0.0301735286200712 11326 98 73 0.744897959183674 0.00644534698922832
GO:BP GO:0044267 cellular protein metabolic process 0.0311924655666933 5229 90 37 0.411111111111111 0.00707592273857334
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0315545033525638 3210 41 14 0.341463414634146 0.0043613707165109
GO:BP GO:0065008 regulation of biological quality 0.0346667133391539 4131 77 27 0.350649350649351 0.0065359477124183
GO:BP GO:0002252 immune effector process 0.0346667133391539 1309 19 5 0.263157894736842 0.00381970970206264
GO:BP GO:0042493 response to drug 0.0364321608160646 396 21 3 0.142857142857143 0.00757575757575758
GO:BP GO:0051234 establishment of localization 0.0369599386381382 5372 42 20 0.476190476190476 0.00372300819061802
GO:BP GO:0002274 myeloid leukocyte activation 0.0411993970970612 667 38 5 0.131578947368421 0.00749625187406297
GO:BP GO:0002181 cytoplasmic translation 0.0430641464846815 103 86 3 0.0348837209302326 0.029126213592233
GO:CC GO:0098798 mitochondrial protein-containing complex 3.75594947531278e-29 270 91 29 0.318681318681319 0.107407407407407
GO:CC GO:1990204 oxidoreductase complex 1.57732041749137e-28 113 71 21 0.295774647887324 0.185840707964602
GO:CC GO:0098803 respiratory chain complex 2.34311233056047e-27 86 71 19 0.267605633802817 0.22093023255814
GO:CC GO:0005746 mitochondrial respirasome 3.61724254758102e-27 89 71 19 0.267605633802817 0.213483146067416
GO:CC GO:0070469 respirasome 6.04820206576739e-26 103 71 19 0.267605633802817 0.184466019417476
GO:CC GO:0005739 mitochondrion 2.48273814854503e-25 1673 91 48 0.527472527472527 0.0286909742976689
GO:CC GO:0098800 inner mitochondrial membrane protein complex 8.8535846795943e-25 146 71 20 0.28169014084507 0.136986301369863
GO:CC GO:0005747 mitochondrial respiratory chain complex I 3.39207084823084e-24 51 91 16 0.175824175824176 0.313725490196078
GO:CC GO:0030964 NADH dehydrogenase complex 3.39207084823084e-24 51 91 16 0.175824175824176 0.313725490196078
GO:CC GO:0045271 respiratory chain complex I 3.39207084823084e-24 51 91 16 0.175824175824176 0.313725490196078
GO:CC GO:1902494 catalytic complex 6.64153139473559e-24 1441 96 45 0.46875 0.0312283136710618
GO:CC GO:0000502 proteasome complex 9.99558520774191e-24 66 96 17 0.177083333333333 0.257575757575758
GO:CC GO:1905369 endopeptidase complex 4.85610790970509e-23 72 96 17 0.177083333333333 0.236111111111111
GO:CC GO:1905368 peptidase complex 1.73703525129986e-22 96 96 18 0.1875 0.1875
GO:CC GO:0005759 mitochondrial matrix 7.38181295610196e-21 479 89 27 0.303370786516854 0.0563674321503132
GO:CC GO:0005743 mitochondrial inner membrane 4.80720953469474e-20 503 91 27 0.296703296703297 0.0536779324055666
GO:CC GO:0019866 organelle inner membrane 8.77187694979117e-19 564 91 27 0.296703296703297 0.0478723404255319
GO:CC GO:0031966 mitochondrial membrane 9.00241053535221e-17 746 91 28 0.307692307692308 0.0375335120643432
GO:CC GO:0005737 cytoplasm 3.56766384531504e-16 11911 98 96 0.979591836734694 0.00805977667702124
GO:CC GO:0005740 mitochondrial envelope 4.50117538496043e-16 797 91 28 0.307692307692308 0.0351317440401506
GO:CC GO:0032991 protein-containing complex 3.05865076225039e-15 5548 96 67 0.697916666666667 0.0120764239365537
GO:CC GO:0005839 proteasome core complex 3.65660468130165e-15 23 83 9 0.108433734939759 0.391304347826087
GO:CC GO:0031967 organelle envelope 6.17587194182879e-14 1237 91 31 0.340659340659341 0.0250606305578011
GO:CC GO:0031975 envelope 6.17587194182879e-14 1237 91 31 0.340659340659341 0.0250606305578011
GO:CC GO:0043227 membrane-bounded organelle 3.26227808627575e-13 12858 98 96 0.979591836734694 0.00746616892207186
GO:CC GO:0005838 proteasome regulatory particle 1.01969639783412e-12 22 96 8 0.0833333333333333 0.363636363636364
GO:CC GO:0022624 proteasome accessory complex 3.28028166979586e-12 25 96 8 0.0833333333333333 0.32
GO:CC GO:0098796 membrane protein complex 7.92728220043769e-12 1322 72 26 0.361111111111111 0.0196671709531014
GO:CC GO:0043226 organelle 4.05822322451383e-11 14008 98 97 0.989795918367347 0.00692461450599657
GO:CC GO:0043231 intracellular membrane-bounded organelle 4.19868526995715e-11 11296 98 89 0.908163265306122 0.00787889518413598
GO:CC GO:0070013 intracellular organelle lumen 2.01929091597645e-10 5402 92 57 0.619565217391304 0.0105516475379489
GO:CC GO:0043229 intracellular organelle 2.37951534965334e-10 12491 93 88 0.946236559139785 0.00704507245216556
GO:CC GO:0031974 membrane-enclosed lumen 6.70459449324957e-10 5565 92 57 0.619565217391304 0.0102425876010782
GO:CC GO:0043233 organelle lumen 6.70459449324957e-10 5565 92 57 0.619565217391304 0.0102425876010782
GO:CC GO:0070062 extracellular exosome 2.1283078831631e-09 2176 63 27 0.428571428571429 0.0124080882352941
GO:CC GO:0019774 proteasome core complex, beta-subunit complex 2.54206923280114e-09 11 73 5 0.0684931506849315 0.454545454545455
GO:CC GO:0043230 extracellular organelle 4.7559201648338e-09 2263 63 27 0.428571428571429 0.0119310649580203
GO:CC GO:1903561 extracellular vesicle 4.7559201648338e-09 2261 63 27 0.428571428571429 0.0119416187527643
GO:CC GO:0005622 intracellular anatomical structure 5.06041275057627e-09 14790 98 97 0.989795918367347 0.00655848546315078
GO:CC GO:0019773 proteasome core complex, alpha-subunit complex 4.81349776818409e-07 10 83 4 0.0481927710843374 0.4
GO:CC GO:0031090 organelle membrane 1.09265381469716e-06 3612 98 41 0.418367346938776 0.0113510520487265
GO:CC GO:0031982 vesicle 1.10550091886619e-06 4055 43 25 0.581395348837209 0.0061652281134402
GO:CC GO:0008540 proteasome regulatory particle, base subcomplex 1.45437929191653e-06 12 90 4 0.0444444444444444 0.333333333333333
GO:CC GO:0140535 intracellular protein-containing complex 1.69280758830755e-06 767 96 17 0.177083333333333 0.0221642764015645
GO:CC GO:0045257 succinate dehydrogenase complex (ubiquinone) 2.79881331917273e-06 5 71 3 0.0422535211267606 0.6
GO:CC GO:0045283 fumarate reductase complex 2.79881331917273e-06 5 71 3 0.0422535211267606 0.6
GO:CC GO:0045281 succinate dehydrogenase complex 2.79881331917273e-06 5 71 3 0.0422535211267606 0.6
GO:CC GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) 2.79881331917273e-06 5 71 3 0.0422535211267606 0.6
GO:CC GO:0045273 respiratory chain complex II 2.79881331917273e-06 5 71 3 0.0422535211267606 0.6
GO:CC GO:0000313 organellar ribosome 1.92882601258832e-05 88 89 6 0.0674157303370786 0.0681818181818182
GO:CC GO:0005761 mitochondrial ribosome 1.92882601258832e-05 88 89 6 0.0674157303370786 0.0681818181818182
GO:CC GO:0005615 extracellular space 4.66519784933669e-05 3594 43 21 0.488372093023256 0.00584307178631052
GO:CC GO:0005829 cytosol 5.18682918778729e-05 5303 96 47 0.489583333333333 0.0088629077880445
GO:CC GO:0044391 ribosomal subunit 0.000158832018091592 190 89 7 0.0786516853932584 0.0368421052631579
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.000197934425143911 124 96 6 0.0625 0.0483870967741935
GO:CC GO:0042645 mitochondrial nucleoid 0.000539079904816148 45 40 3 0.075 0.0666666666666667
GO:CC GO:0009295 nucleoid 0.000539079904816148 45 40 3 0.075 0.0666666666666667
GO:CC GO:1990904 ribonucleoprotein complex 0.000550636459824344 688 92 12 0.130434782608696 0.0174418604651163
GO:CC GO:0000315 organellar large ribosomal subunit 0.000599679205714677 57 87 4 0.0459770114942529 0.0701754385964912
GO:CC GO:0005762 mitochondrial large ribosomal subunit 0.000599679205714677 57 87 4 0.0459770114942529 0.0701754385964912
GO:CC GO:0005840 ribosome 0.000672425631031477 245 89 7 0.0786516853932584 0.0285714285714286
GO:CC GO:0101002 ficolin-1-rich granule 0.00139559702849976 184 96 6 0.0625 0.0326086956521739
GO:CC GO:0005576 extracellular region 0.00143637870726134 4567 43 21 0.488372093023256 0.00459820451061966
GO:CC GO:0031981 nuclear lumen 0.00144814123361586 4444 97 38 0.391752577319588 0.00855085508550855
GO:CC GO:0005654 nucleoplasm 0.00144814123361586 4102 38 18 0.473684210526316 0.00438810336421258
GO:CC GO:0005634 nucleus 0.00332727619608341 7592 98 55 0.561224489795918 0.00724446786090622
GO:CC GO:0048475 coated membrane 0.00460236990177637 97 93 4 0.043010752688172 0.0412371134020619
GO:CC GO:0030117 membrane coat 0.00460236990177637 97 93 4 0.043010752688172 0.0412371134020619
GO:CC GO:0030667 secretory granule membrane 0.00539367834336938 303 15 3 0.2 0.0099009900990099
GO:CC GO:0015934 large ribosomal subunit 0.00695528933692616 118 87 4 0.0459770114942529 0.0338983050847458
GO:CC GO:0030141 secretory granule 0.0110153943154812 851 15 4 0.266666666666667 0.00470035252643948
GO:CC GO:0015935 small ribosomal subunit 0.015423471484208 75 89 3 0.0337078651685393 0.04
GO:CC GO:0034774 secretory granule lumen 0.0162129561789958 320 96 6 0.0625 0.01875
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.017024192639581 324 96 6 0.0625 0.0185185185185185
GO:CC GO:0031983 vesicle lumen 0.0170811832914304 326 96 6 0.0625 0.0184049079754601
GO:CC GO:0099503 secretory vesicle 0.0185833923600652 1020 15 4 0.266666666666667 0.00392156862745098
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.04686698448392 779 15 3 0.2 0.00385109114249037
GO:CC GO:0012506 vesicle membrane 0.0494794700973724 800 15 3 0.2 0.00375
GO:MF GO:0009055 electron transfer activity 2.75678568670778e-26 148 91 23 0.252747252747253 0.155405405405405
GO:MF GO:0016491 oxidoreductase activity 2.75678568670778e-26 771 71 34 0.47887323943662 0.0440985732814527
GO:MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 1.47532877309289e-22 46 91 15 0.164835164835165 0.326086956521739
GO:MF GO:0050136 NADH dehydrogenase (quinone) activity 1.47532877309289e-22 46 91 15 0.164835164835165 0.326086956521739
GO:MF GO:0003954 NADH dehydrogenase activity 1.47532877309289e-22 46 91 15 0.164835164835165 0.326086956521739
GO:MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity 3.74205505540739e-22 49 91 15 0.164835164835165 0.306122448979592
GO:MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1.37149396815252e-20 61 91 15 0.164835164835165 0.245901639344262
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 6.69661794877337e-17 107 69 14 0.202898550724638 0.130841121495327
GO:MF GO:0003824 catalytic activity 3.07604011734456e-14 5896 74 57 0.77027027027027 0.00966757123473541
GO:MF GO:0004298 threonine-type endopeptidase activity 2.23599998563131e-10 14 73 6 0.0821917808219178 0.428571428571429
GO:MF GO:0070003 threonine-type peptidase activity 8.83444959593563e-09 24 73 6 0.0821917808219178 0.25
GO:MF GO:0016209 antioxidant activity 5.16433720666378e-08 87 27 6 0.222222222222222 0.0689655172413793
GO:MF GO:0004601 peroxidase activity 2.37157316324312e-07 53 27 5 0.185185185185185 0.0943396226415094
GO:MF GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 3.20054165079937e-07 57 27 5 0.185185185185185 0.087719298245614
GO:MF GO:0004602 glutathione peroxidase activity 3.58748433621436e-07 21 27 4 0.148148148148148 0.19047619047619
GO:MF GO:0004364 glutathione transferase activity 7.08067787024382e-07 25 27 4 0.148148148148148 0.16
GO:MF GO:0051287 NAD binding 1.80287035178774e-06 55 79 6 0.0759493670886076 0.109090909090909
GO:MF GO:0000104 succinate dehydrogenase activity 7.68032658249469e-06 5 71 3 0.0422535211267606 0.6
GO:MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 1.37253473628035e-05 125 79 7 0.0886075949367089 0.056
GO:MF GO:0036402 proteasome-activating ATPase activity 1.41862337247442e-05 5 90 3 0.0333333333333333 0.6
GO:MF GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 1.75144182377107e-05 58 27 4 0.148148148148148 0.0689655172413793
GO:MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 2.10008246113715e-05 137 79 7 0.0886075949367089 0.0510948905109489
GO:MF GO:0004175 endopeptidase activity 2.10008246113715e-05 450 36 8 0.222222222222222 0.0177777777777778
GO:MF GO:0008233 peptidase activity 4.44095830519613e-05 646 58 11 0.189655172413793 0.0170278637770898
GO:MF GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors 5.02873112507267e-05 65 71 5 0.0704225352112676 0.0769230769230769
GO:MF GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 0.000118619827932871 38 70 4 0.0571428571428571 0.105263157894737
GO:MF GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.000238697525727669 46 70 4 0.0571428571428571 0.0869565217391304
GO:MF GO:0048038 quinone binding 0.000329722975572175 19 65 3 0.0461538461538462 0.157894736842105
GO:MF GO:0051540 metal cluster binding 0.000342157484203361 70 52 4 0.0769230769230769 0.0571428571428571
GO:MF GO:0051536 iron-sulfur cluster binding 0.000342157484203361 70 52 4 0.0769230769230769 0.0571428571428571
GO:MF GO:0051539 4 iron, 4 sulfur cluster binding 0.000555544838775182 44 35 3 0.0857142857142857 0.0681818181818182
GO:MF GO:0008135 translation factor activity, RNA binding 0.0057424339666715 99 86 4 0.0465116279069767 0.0404040404040404
GO:MF GO:0003735 structural constituent of ribosome 0.00627688417105813 171 89 5 0.0561797752808989 0.0292397660818713
GO:MF GO:0003743 translation initiation factor activity 0.00858883397360857 58 86 3 0.0348837209302326 0.0517241379310345
GO:MF GO:0090079 translation regulator activity, nucleic acid binding 0.00858883397360857 123 86 4 0.0465116279069767 0.032520325203252
GO:MF GO:0016787 hydrolase activity 0.014135789248233 2615 58 16 0.275862068965517 0.00611854684512428
GO:MF GO:0045182 translation regulator activity 0.0152588121837552 155 86 4 0.0465116279069767 0.0258064516129032
GO:MF GO:0016829 lyase activity 0.0155991648177491 203 34 3 0.0882352941176471 0.0147783251231527
GO:MF GO:0005515 protein binding 0.0245187958074029 14767 44 41 0.931818181818182 0.00277646102796777
GO:MF GO:0008237 metallopeptidase activity 0.037732827844315 188 55 3 0.0545454545454545 0.0159574468085106
GO:MF GO:0005198 structural molecule activity 0.037732827844315 698 89 8 0.0898876404494382 0.0114613180515759
HP HP:0002490 Increased CSF lactate 2.75297803514713e-11 91 53 15 0.283018867924528 0.164835164835165
HP HP:0030085 Abnormal CSF lactate level 2.75297803514713e-11 91 53 15 0.283018867924528 0.164835164835165
HP HP:0007183 Focal T2 hyperintense basal ganglia lesion 1.32270813698117e-10 40 52 11 0.211538461538462 0.275
HP HP:0025454 Abnormal CSF metabolite level 2.52964296979782e-10 110 53 15 0.283018867924528 0.136363636363636
HP HP:0002928 Decreased activity of the pyruvate dehydrogenase complex 3.39762437399313e-10 34 70 11 0.157142857142857 0.323529411764706
HP HP:0012751 Abnormal basal ganglia MRI signal intensity 9.81825103370371e-10 50 52 11 0.211538461538462 0.22
HP HP:0008972 Decreased activity of mitochondrial respiratory chain 1.17192208777093e-09 84 53 13 0.245283018867925 0.154761904761905
HP HP:0011922 Abnormal activity of mitochondrial respiratory chain 1.20041573252552e-09 85 53 13 0.245283018867925 0.152941176470588
HP HP:0002415 Leukodystrophy 1.32797114876784e-08 103 53 13 0.245283018867925 0.12621359223301
HP HP:0003287 Abnormality of mitochondrial metabolism 3.25057363418312e-08 139 82 17 0.207317073170732 0.122302158273381
HP HP:0007020 Progressive spastic paraplegia 7.3454973047572e-08 58 52 10 0.192307692307692 0.172413793103448
HP HP:0004366 Abnormality of glycolysis 2.19372343462559e-07 47 53 9 0.169811320754717 0.191489361702128
HP HP:0003542 Increased serum pyruvate 2.19372343462559e-07 47 53 9 0.169811320754717 0.191489361702128
HP HP:0012103 Abnormality of the mitochondrion 2.66993050442142e-07 163 53 14 0.264150943396226 0.0858895705521472
HP HP:0002151 Increased serum lactate 3.84870428015285e-07 172 52 14 0.269230769230769 0.0813953488372093
HP HP:0001941 Acidosis 1.07512363463779e-06 335 82 23 0.280487804878049 0.0686567164179104
HP HP:0011013 Abnormal circulating carbohydrate concentration 1.6206504101144e-06 60 53 9 0.169811320754717 0.15
HP HP:0002073 Progressive cerebellar ataxia 1.89791918732827e-06 84 52 10 0.192307692307692 0.119047619047619
HP HP:0012748 Focal T2 hyperintense brainstem lesion 3.9610387335981e-06 32 53 7 0.132075471698113 0.21875
HP HP:0004360 Abnormality of acid-base homeostasis 3.9610387335981e-06 363 82 23 0.280487804878049 0.0633608815426997
HP HP:0011923 Decreased activity of mitochondrial complex I 4.14504023124918e-06 49 53 8 0.150943396226415 0.163265306122449
HP HP:0001639 Hypertrophic cardiomyopathy 4.14504023124918e-06 244 53 15 0.283018867924528 0.0614754098360656
HP HP:0000580 Pigmentary retinopathy 6.41259818400304e-06 151 53 12 0.226415094339623 0.0794701986754967
HP HP:0008316 Abnormal mitochondria in muscle tissue 1.08649827029556e-05 38 53 7 0.132075471698113 0.184210526315789
HP HP:0007704 Paroxysmal involuntary eye movements 1.08649827029556e-05 38 53 7 0.132075471698113 0.184210526315789
HP HP:0003128 Lactic acidosis 1.15529500450467e-05 161 53 12 0.226415094339623 0.0745341614906832
HP HP:0012747 Abnormal brainstem MRI signal intensity 1.21505549199136e-05 39 53 7 0.132075471698113 0.179487179487179
HP HP:0002134 Abnormality of the basal ganglia 1.28271255280334e-05 201 52 13 0.25 0.0646766169154229
HP HP:0025116 Fetal distress 1.62392043037157e-05 41 53 7 0.132075471698113 0.170731707317073
HP HP:0000712 Emotional lability 2.55004409704903e-05 116 52 10 0.192307692307692 0.0862068965517241
HP HP:0002421 Poor head control 3.08609611232063e-05 179 53 12 0.226415094339623 0.0670391061452514
HP HP:0003800 Muscle abnormality related to mitochondrial dysfunction 4.38723132142846e-05 69 53 8 0.150943396226415 0.115942028985507
HP HP:0000114 Proximal tubulopathy 4.38723132142846e-05 48 53 7 0.132075471698113 0.145833333333333
HP HP:0001258 Spastic paraplegia 5.24287096207147e-05 127 52 10 0.192307692307692 0.078740157480315
HP HP:0003737 Mitochondrial myopathy 9.42435537809775e-05 54 53 7 0.132075471698113 0.12962962962963
HP HP:0031284 Flushing 0.000107902913614034 26 74 6 0.0810810810810811 0.230769230769231
HP HP:0001138 Optic neuropathy 0.000129525839031231 57 53 7 0.132075471698113 0.12280701754386
HP HP:0012222 Arachnoid hemangiomatosis 0.000138416137417602 16 74 5 0.0675675675675676 0.3125
HP HP:0009711 Retinal capillary hemangioma 0.000138416137417602 16 74 5 0.0675675675675676 0.3125
HP HP:0000740 Episodic paroxysmal anxiety 0.00017158242003704 17 74 5 0.0675675675675676 0.294117647058824
HP HP:0002864 Paraganglioma of head and neck 0.00017158242003704 17 74 5 0.0675675675675676 0.294117647058824
HP HP:0008629 Pulsatile tinnitus 0.00017158242003704 17 74 5 0.0675675675675676 0.294117647058824
HP HP:0006737 Extraadrenal pheochromocytoma 0.00017158242003704 17 74 5 0.0675675675675676 0.294117647058824
HP HP:0003639 Elevated urinary epinephrine 0.00017158242003704 17 74 5 0.0675675675675676 0.294117647058824
HP HP:0011400 Abnormal CNS myelination 0.000198216102317549 261 53 13 0.245283018867925 0.0498084291187739
HP HP:0011979 Elevated urinary dopamine 0.000198453530428829 18 74 5 0.0675675675675676 0.277777777777778
HP HP:0010797 Hemangioblastoma 0.000198453530428829 18 74 5 0.0675675675675676 0.277777777777778
HP HP:0010532 Paroxysmal vertigo 0.000198453530428829 18 74 5 0.0675675675675676 0.277777777777778
HP HP:0003574 Positive regitine blocking test 0.000198453530428829 18 74 5 0.0675675675675676 0.277777777777778
HP HP:0006748 Adrenal pheochromocytoma 0.000198453530428829 18 74 5 0.0675675675675676 0.277777777777778
HP HP:0100642 Neoplasm of the adrenal medulla 0.000198453530428829 18 74 5 0.0675675675675676 0.277777777777778
HP HP:0003345 Elevated urinary norepinephrine 0.000198453530428829 18 74 5 0.0675675675675676 0.277777777777778
HP HP:0010550 Paraplegia 0.000245322831204608 158 52 10 0.192307692307692 0.0632911392405063
HP HP:0002640 Hypertension associated with pheochromocytoma 0.000251381728594106 19 74 5 0.0675675675675676 0.263157894736842
HP HP:0001095 Hypertensive retinopathy 0.000251381728594106 19 74 5 0.0675675675675676 0.263157894736842
HP HP:0002061 Lower limb spasticity 0.00028803940955784 199 52 11 0.211538461538462 0.0552763819095477
HP HP:0002668 Paraganglioma 0.000319278776518368 20 74 5 0.0675675675675676 0.25
HP HP:0030074 Chemodectoma 0.000346591659376615 4 71 3 0.0422535211267606 0.75
HP HP:0001942 Metabolic acidosis 0.000382399844347485 135 78 11 0.141025641025641 0.0814814814814815
HP HP:0011703 Sinus tachycardia 0.000493868188556662 22 74 5 0.0675675675675676 0.227272727272727
HP HP:0009594 Retinal hamartoma 0.000493868188556662 22 74 5 0.0675675675675676 0.227272727272727
HP HP:0010551 Paraplegia/paraparesis 0.000541695166517915 215 52 11 0.211538461538462 0.0511627906976744
HP HP:0000998 Hypertrichosis 0.00058152363119764 217 52 11 0.211538461538462 0.0506912442396313
HP HP:0001069 Episodic hyperhidrosis 0.000584650082718359 23 74 5 0.0675675675675676 0.217391304347826
HP HP:0003528 Elevated calcitonin 0.000584650082718359 23 74 5 0.0675675675675676 0.217391304347826
HP HP:0001298 Encephalopathy 0.000708521306149248 260 53 12 0.226415094339623 0.0461538461538462
HP HP:0003001 Glomus jugular tumor 0.000741563939668727 5 71 3 0.0422535211267606 0.6
HP HP:0000602 Ophthalmoplegia 0.000833341547340829 249 65 13 0.2 0.0522088353413655
HP HP:0011976 Elevated urinary catecholamines 0.00100674405269968 26 74 5 0.0675675675675676 0.192307692307692
HP HP:0002331 Recurrent paroxysmal headache 0.00100674405269968 26 74 5 0.0675675675675676 0.192307692307692
HP HP:0011281 Abnormality of urine catecholamine concentration 0.00100674405269968 26 74 5 0.0675675675675676 0.192307692307692
HP HP:0000817 Poor eye contact 0.00104060109228664 86 53 7 0.132075471698113 0.0813953488372093
HP HP:0002666 Pheochromocytoma 0.00118635157562197 27 74 5 0.0675675675675676 0.185185185185185
HP HP:0010568 Hamartoma of the eye 0.00165550698527155 29 74 5 0.0675675675675676 0.172413793103448
HP HP:0030670 Hamartoma of the orbital region 0.00165550698527155 29 74 5 0.0675675675675676 0.172413793103448
HP HP:0007703 Abnormality of retinal pigmentation 0.00243920349271397 319 65 14 0.215384615384615 0.0438871473354232
HP HP:0000597 Ophthalmoparesis 0.00256602901673354 281 65 13 0.2 0.0462633451957295
HP HP:0000124 Renal tubular dysfunction 0.0026843342020495 101 53 7 0.132075471698113 0.0693069306930693
HP HP:0100634 Neuroendocrine neoplasm 0.00298379740318116 33 74 5 0.0675675675675676 0.151515151515152
HP HP:0001638 Cardiomyopathy 0.00326187264487315 463 53 15 0.283018867924528 0.0323974082073434
HP HP:0002574 Episodic abdominal pain 0.00332728209472813 34 74 5 0.0675675675675676 0.147058823529412
HP HP:0032148 Episodic pain 0.00332728209472813 34 74 5 0.0675675675675676 0.147058823529412
HP HP:0001943 Hypoglycemia 0.0037104772008053 224 53 10 0.188679245283019 0.0446428571428571
HP HP:0010864 Intellectual disability, severe 0.00493658620863125 384 52 13 0.25 0.0338541666666667
HP HP:0001637 Abnormal myocardium morphology 0.00538325950223352 487 53 15 0.283018867924528 0.0308008213552361
HP HP:0000618 Blindness 0.005432594936962 266 65 12 0.184615384615385 0.0451127819548872
HP HP:0002921 Abnormality of the cerebrospinal fluid 0.0058831208255034 492 53 15 0.283018867924528 0.0304878048780488
HP HP:0000543 Optic disc pallor 0.00614100131623357 139 59 8 0.135593220338983 0.0575539568345324
HP HP:0012707 Elevated brain lactate level by MRS 0.0061560851519013 17 40 3 0.075 0.176470588235294
HP HP:0100631 Neoplasm of the adrenal gland 0.0065649517351919 40 74 5 0.0675675675675676 0.125
HP HP:0001293 Cranial nerve compression 0.0065649517351919 40 74 5 0.0675675675675676 0.125
HP HP:0000735 Impaired social interactions 0.00697065229017553 121 53 7 0.132075471698113 0.0578512396694215
HP HP:0025045 Abnormal brain lactate level by MRS 0.00702598561275522 18 40 3 0.075 0.166666666666667
HP HP:0031801 Vocal cord dysfunction 0.00706621834483738 41 74 5 0.0675675675675676 0.121951219512195
HP HP:0001605 Vocal cord paralysis 0.00706621834483738 41 74 5 0.0675675675675676 0.121951219512195
HP HP:0011015 Abnormal blood glucose concentration 0.00706621834483738 247 53 10 0.188679245283019 0.0404858299595142
HP HP:0100780 Conjunctival hamartoma 0.00789263241746538 11 71 3 0.0422535211267606 0.272727272727273
HP HP:0100530 Abnormal calcium-phosphate regulating hormone level 0.00858161692638745 43 74 5 0.0675675675675676 0.116279069767442
HP HP:0000526 Aniridia 0.00927471645964125 44 74 5 0.0675675675675676 0.113636363636364
HP HP:0002352 Leukoencephalopathy 0.00950146694548581 205 78 11 0.141025641025641 0.0536585365853659
HP HP:0100012 Neoplasm of the eye 0.0111890368022022 46 74 5 0.0675675675675676 0.108695652173913
HP HP:0011017 Abnormal cellular physiology 0.014106029734705 485 53 14 0.264150943396226 0.0288659793814433
HP HP:0002104 Apnea 0.016878211489109 285 52 10 0.192307692307692 0.0350877192982456
HP HP:0012447 Abnormal myelination 0.0172824617665359 497 53 14 0.264150943396226 0.028169014084507
HP HP:0001629 Ventricular septal defect 0.0172824617665359 385 53 12 0.226415094339623 0.0311688311688312
HP HP:0001254 Lethargy 0.0178572743944864 189 53 8 0.150943396226415 0.0423280423280423
HP HP:0006731 Follicular thyroid carcinoma 0.0178640070409357 15 71 3 0.0422535211267606 0.2
HP HP:0025354 Abnormal cellular phenotype 0.0178640070409357 501 53 14 0.264150943396226 0.0279441117764471
HP HP:0010438 Abnormal ventricular septum morphology 0.0195437431052867 393 53 12 0.226415094339623 0.0305343511450382
HP HP:0100833 Neoplasm of the small intestine 0.0213462527031403 16 71 3 0.0422535211267606 0.1875
HP HP:0002018 Nausea 0.0227675183405056 73 82 6 0.0731707317073171 0.0821917808219178
HP HP:0000360 Tinnitus 0.0235515351449381 56 74 5 0.0675675675675676 0.0892857142857143
HP HP:0003072 Hypercalcemia 0.0235515351449381 56 74 5 0.0675675675675676 0.0892857142857143
HP HP:0005595 Generalized hyperkeratosis 0.0241576195001014 17 71 3 0.0422535211267606 0.176470588235294
HP HP:0004390 Hamartomatous polyposis 0.0241576195001014 17 71 3 0.0422535211267606 0.176470588235294
HP HP:0001332 Dystonia 0.0253009857102884 475 52 13 0.25 0.0273684210526316
HP HP:0100007 Neoplasm of the peripheral nervous system 0.0264379745244045 58 74 5 0.0675675675675676 0.0862068965517241
HP HP:0100723 Gastrointestinal stroma tumor 0.0277524527492754 18 71 3 0.0422535211267606 0.166666666666667
HP HP:0012705 Abnormal metabolic brain imaging by MRS 0.0286847154636269 32 40 3 0.075 0.09375
HP HP:0001342 Cerebral hemorrhage 0.029765628794587 60 74 5 0.0675675675675676 0.0833333333333333
HP HP:0002363 Abnormal brainstem morphology 0.029765628794587 219 74 10 0.135135135135135 0.045662100456621
HP HP:0008675 Enlarged polycystic ovaries 0.0312848935105477 19 71 3 0.0422535211267606 0.157894736842105
HP HP:0033052 Psychogenic non-epileptic seizure 0.0312848935105477 61 74 5 0.0675675675675676 0.0819672131147541
HP HP:0025269 Panic attack 0.0312848935105477 61 74 5 0.0675675675675676 0.0819672131147541
HP HP:0100879 Enlarged ovaries 0.0359085406459796 20 71 3 0.0422535211267606 0.15
HP HP:0010549 Weakness due to upper motor neuron dysfunction 0.0377334914425049 459 44 11 0.25 0.0239651416122004
HP HP:0011702 Abnormal electrophysiology of sinoatrial node origin 0.0377334914425049 64 74 5 0.0675675675675676 0.078125
HP HP:0012433 Abnormal social behavior 0.0391773113690553 174 53 7 0.132075471698113 0.0402298850574713
HP HP:0009720 Adenoma sebaceum 0.0399211651874228 21 71 3 0.0422535211267606 0.142857142857143
HP HP:0001511 Intrauterine growth retardation 0.042209120817013 500 53 13 0.245283018867925 0.026
HP HP:0100751 Esophageal neoplasm 0.0442300781467615 21 74 3 0.0405405405405405 0.142857142857143
HP HP:0011343 Moderate global developmental delay 0.0445434031830319 24 65 3 0.0461538461538462 0.125
HP HP:0012032 Lipoma 0.0445434031830319 22 71 3 0.0422535211267606 0.136363636363636
HP HP:0001962 Palpitations 0.048927072452757 69 74 5 0.0675675675675676 0.072463768115942
HP HP:0005584 Renal cell carcinoma 0.048927072452757 69 74 5 0.0675675675675676 0.072463768115942
HP HP:0012114 Endometrial carcinoma 0.0491222300108952 23 71 3 0.0422535211267606 0.130434782608696
HP HP:0200063 Colorectal polyposis 0.0491222300108952 23 71 3 0.0422535211267606 0.130434782608696
HP HP:0001423 X-linked dominant inheritance 0.0494516092276745 61 53 4 0.0754716981132075 0.0655737704918033
HPA HPA:0290402 liver; hepatocytes[≥Medium] 2.14629257754639e-10 3640 66 51 0.772727272727273 0.014010989010989
HPA HPA:0020052 adrenal gland; glandular cells[≥Medium] 7.81763595457112e-08 5867 79 69 0.873417721518987 0.0117606954150332
HPA HPA:0241103 heart muscle; cardiomyocytes[High] 1.08065901558929e-07 1113 91 31 0.340659340659341 0.0278526504941599
HPA HPA:0470682 skin 2; epidermal cells[≥Medium] 1.64883125472214e-07 4735 79 61 0.772151898734177 0.012882787750792
HPA HPA:0130053 colon; glandular cells[High] 1.9458117675218e-07 2538 92 48 0.521739130434783 0.0189125295508274
HPA HPA:0610832 urinary bladder; urothelial cells[≥Medium] 2.06714403295076e-07 5819 94 78 0.829787234042553 0.0134043650111703
HPA HPA:0190222 esophagus; squamous epithelial cells[≥Medium] 3.89694920700859e-07 4937 93 70 0.752688172043011 0.0141786510026332
HPA HPA:0320102 nasopharynx; respiratory epithelial cells[≥Medium] 4.42135397300015e-07 5010 94 71 0.75531914893617 0.0141716566866267
HPA HPA:0060102 bronchus; respiratory epithelial cells[≥Medium] 5.89805181100727e-07 5184 94 72 0.765957446808511 0.0138888888888889
HPA HPA:0291161 liver; cholangiocytes[≥Low] 5.89805181100727e-07 3867 40 32 0.8 0.0082751486940781
HPA HPA:0290401 liver; hepatocytes[≥Low] 8.00853410641499e-07 5611 66 56 0.848484848484849 0.00998039565139904
HPA HPA:0270362 kidney; cells in tubules[≥Medium] 8.74873640936119e-07 6318 67 60 0.895522388059702 0.00949667616334283
HPA HPA:0400053 rectum; glandular cells[High] 1.32726900621829e-06 2687 94 48 0.51063829787234 0.0178637886118348
HPA HPA:0400052 rectum; glandular cells[≥Medium] 1.75915727634834e-06 6410 94 80 0.851063829787234 0.0124804992199688
HPA HPA:0290000 liver 1.75915727634834e-06 6158 66 58 0.878787878787879 0.00941864241636895
HPA HPA:0080132 caudate; neuronal cells[≥Medium] 1.78683345152952e-06 4022 77 52 0.675324675324675 0.0129288910989557
HPA HPA:0540053 stomach 1; glandular cells[High] 1.7987569704578e-06 2365 94 44 0.468085106382979 0.0186046511627907
HPA HPA:0110052 cervix, uterine; glandular cells[≥Medium] 2.04217043256968e-06 3938 67 46 0.686567164179104 0.0116810563737938
HPA HPA:0360052 parathyroid gland; glandular cells[≥Medium] 2.09648271221182e-06 4306 94 63 0.670212765957447 0.0146307477937761
HPA HPA:0480052 small intestine; glandular cells[≥Medium] 2.4374985228524e-06 6461 66 59 0.893939393939394 0.00913171335706547
HPA HPA:0290403 liver; hepatocytes[High] 2.5153758049943e-06 839 35 14 0.4 0.0166865315852205
HPA HPA:0480053 small intestine; glandular cells[High] 2.5153758049943e-06 2723 93 47 0.505376344086022 0.0172603745868527
HPA HPA:0250132 hippocampus; neuronal cells[≥Medium] 2.5890380722119e-06 4126 92 60 0.652173913043478 0.0145419292292778
HPA HPA:0390052 prostate; glandular cells[≥Medium] 2.68065326026255e-06 4699 94 66 0.702127659574468 0.0140455416045967
HPA HPA:0550052 stomach 2; glandular cells[≥Medium] 2.78825350585126e-06 6134 67 58 0.865671641791045 0.00945549396804695
HPA HPA:0430052 seminal vesicle; glandular cells[≥Medium] 3.58024443503807e-06 5096 94 69 0.734042553191489 0.0135400313971743
HPA HPA:0020053 adrenal gland; glandular cells[High] 3.85956973054685e-06 2199 97 42 0.43298969072165 0.0190995907230559
HPA HPA:0241102 heart muscle; cardiomyocytes[≥Medium] 4.27445108697324e-06 4249 56 41 0.732142857142857 0.0096493292539421
HPA HPA:0210052 fallopian tube; glandular cells[≥Medium] 5.02482060233579e-06 5023 94 68 0.723404255319149 0.0135377264582919
HPA HPA:0050011 breast; adipocytes[≥Low] 5.74283648050664e-06 2725 93 46 0.494623655913978 0.0168807339449541
HPA HPA:0150052 duodenum; glandular cells[≥Medium] 6.06189278295634e-06 6480 67 59 0.880597014925373 0.00910493827160494
HPA HPA:0570732 testis; Leydig cells[≥Medium] 6.06189278295634e-06 5295 94 70 0.74468085106383 0.0132200188857413
HPA HPA:0270363 kidney; cells in tubules[High] 6.30642685655176e-06 2461 93 43 0.462365591397849 0.0174725721251524
HPA HPA:0351182 pancreas; pancreatic endocrine cells[≥Medium] 6.30642685655176e-06 3523 98 56 0.571428571428571 0.0158955435708203
HPA HPA:0100133 cerebral cortex; neuronal cells[High] 6.87008036803498e-06 1785 92 35 0.380434782608696 0.0196078431372549
HPA HPA:0420051 salivary gland; glandular cells[≥Low] 7.38369902026755e-06 6744 67 60 0.895522388059702 0.00889679715302491
HPA HPA:0420000 salivary gland 7.38369902026755e-06 6744 67 60 0.895522388059702 0.00889679715302491
HPA HPA:0540052 stomach 1; glandular cells[≥Medium] 7.54915844416917e-06 6201 86 71 0.825581395348837 0.0114497661667473
HPA HPA:0160052 endometrium 1; glandular cells[≥Medium] 8.1391461459557e-06 5014 59 46 0.779661016949153 0.00917431192660551
HPA HPA:0110051 cervix, uterine; glandular cells[≥Low] 9.21636018038611e-06 5579 64 52 0.8125 0.00932066678616239
HPA HPA:0020051 adrenal gland; glandular cells[≥Low] 1.02292258879766e-05 7265 67 62 0.925373134328358 0.00853406744666208
HPA HPA:0020000 adrenal gland 1.04270265308743e-05 7271 67 62 0.925373134328358 0.00852702516847751
HPA HPA:0130052 colon; glandular cells[≥Medium] 1.26000937121205e-05 6278 86 71 0.825581395348837 0.0113093341828608
HPA HPA:0530722 spleen; cells in white pulp[≥Medium] 1.3569607444966e-05 2645 93 44 0.473118279569892 0.0166351606805293
HPA HPA:0360053 parathyroid gland; glandular cells[High] 1.40937645276397e-05 1486 94 31 0.329787234042553 0.0208613728129206
HPA HPA:0030053 appendix; glandular cells[High] 1.40937645276397e-05 1986 94 37 0.393617021276596 0.0186304128902316
HPA HPA:0430000 seminal vesicle 1.60756349693326e-05 6672 67 59 0.880597014925373 0.00884292565947242
HPA HPA:0430051 seminal vesicle; glandular cells[≥Low] 1.60756349693326e-05 6672 67 59 0.880597014925373 0.00884292565947242
HPA HPA:0610831 urinary bladder; urothelial cells[≥Low] 1.80659595029998e-05 7141 67 61 0.91044776119403 0.00854222097745414
HPA HPA:0460672 skin 1; melanocytes[≥Medium] 1.80659595029998e-05 3700 93 54 0.580645161290323 0.0145945945945946
HPA HPA:0610000 urinary bladder 1.80659595029998e-05 7141 67 61 0.91044776119403 0.00854222097745414
HPA HPA:0030051 appendix; glandular cells[≥Low] 1.80659595029998e-05 7142 67 61 0.91044776119403 0.00854102492299076
HPA HPA:0090182 cerebellum; cells in granular layer[≥Medium] 1.92867348429806e-05 2854 65 35 0.538461538461538 0.0122634898388227
HPA HPA:0590051 thyroid gland; glandular cells[≥Low] 2.30468626248886e-05 6963 67 60 0.895522388059702 0.00861697544161999
HPA HPA:0030052 appendix; glandular cells[≥Medium] 2.30468626248886e-05 5767 94 72 0.765957446808511 0.0124848274666204
HPA HPA:0590000 thyroid gland 2.30468626248886e-05 6963 67 60 0.895522388059702 0.00861697544161999
HPA HPA:0430053 seminal vesicle; glandular cells[High] 2.4192720676276e-05 1410 97 30 0.309278350515464 0.0212765957446809
HPA HPA:0350472 pancreas; exocrine glandular cells[≥Medium] 2.4192720676276e-05 5157 94 67 0.712765957446808 0.0129920496412643
HPA HPA:0220053 gallbladder; glandular cells[High] 2.42236726214047e-05 2772 78 39 0.5 0.0140692640692641
HPA HPA:0150053 duodenum; glandular cells[High] 2.52252325018202e-05 2767 92 44 0.478260869565217 0.0159016985905313
HPA HPA:0170051 endometrium 2; glandular cells[≥Low] 2.6343675370994e-05 6568 67 58 0.865671641791045 0.00883069427527406
HPA HPA:0250133 hippocampus; neuronal cells[High] 2.92277843123654e-05 1210 70 22 0.314285714285714 0.0181818181818182
HPA HPA:0180052 epididymis; glandular cells[≥Medium] 2.95157757460012e-05 5560 94 70 0.74468085106383 0.012589928057554
HPA HPA:0210051 fallopian tube; glandular cells[≥Low] 3.31241023956215e-05 6089 94 74 0.787234042553192 0.012153062900312
HPA HPA:0090192 cerebellum; cells in molecular layer[≥Medium] 3.31241023956215e-05 2699 59 31 0.525423728813559 0.0114857354575769
HPA HPA:0060101 bronchus; respiratory epithelial cells[≥Low] 3.34909251915996e-05 6226 94 75 0.797872340425532 0.0120462576292965
HPA HPA:0100211 cerebral cortex; neuropil[≥Low] 3.34909251915996e-05 4942 91 63 0.692307692307692 0.0127478753541076
HPA HPA:0420052 salivary gland; glandular cells[≥Medium] 3.46050262780079e-05 4742 64 46 0.71875 0.00970054829185998
HPA HPA:0600431 tonsil; germinal center cells[≥Low] 3.51607842526666e-05 5845 94 72 0.765957446808511 0.0123182207014542
HPA HPA:0460641 skin 1; Langerhans[≥Low] 3.66316272846631e-05 4634 67 47 0.701492537313433 0.0101424255502805
HPA HPA:0390000 prostate 3.89206082121852e-05 6528 94 77 0.819148936170213 0.0117953431372549
HPA HPA:0570733 testis; Leydig cells[High] 3.89206082121852e-05 1718 92 32 0.347826086956522 0.0186263096623981
HPA HPA:0390051 prostate; glandular cells[≥Low] 3.89206082121852e-05 6528 94 77 0.819148936170213 0.0117953431372549
HPA HPA:0460662 skin 1; keratinocytes[≥Medium] 3.89206082121852e-05 3893 98 57 0.581632653061224 0.0146416645260724
HPA HPA:0570801 testis; sertoli cells[≥Low] 3.89206082121852e-05 2256 92 38 0.41304347826087 0.0168439716312057
HPA HPA:0351181 pancreas; pancreatic endocrine cells[≥Low] 4.02403640313287e-05 5497 94 69 0.734042553191489 0.0125523012552301
HPA HPA:0291162 liver; cholangiocytes[≥Medium] 4.24215124576069e-05 1910 52 23 0.442307692307692 0.0120418848167539
HPA HPA:0320101 nasopharynx; respiratory epithelial cells[≥Low] 4.24215124576069e-05 6079 67 55 0.82089552238806 0.00904754071393321
HPA HPA:0610833 urinary bladder; urothelial cells[High] 4.49546933968993e-05 1969 97 36 0.371134020618557 0.0182833925850686
HPA HPA:0570802 testis; sertoli cells[≥Medium] 5.21176057806717e-05 1662 92 31 0.33695652173913 0.0186522262334537
HPA HPA:0220052 gallbladder; glandular cells[≥Medium] 5.27962210468871e-05 6461 66 56 0.848484848484849 0.00866738894907909
HPA HPA:0160053 endometrium 1; glandular cells[High] 5.27962210468871e-05 1413 97 29 0.298969072164948 0.0205237084217976
HPA HPA:0150051 duodenum; glandular cells[≥Low] 5.27962210468871e-05 7606 67 62 0.925373134328358 0.00815145937417828
HPA HPA:0150000 duodenum 5.27962210468871e-05 7606 67 62 0.925373134328358 0.00815145937417828
HPA HPA:0080131 caudate; neuronal cells[≥Low] 5.27962210468871e-05 6042 59 49 0.830508474576271 0.00810989738497186
HPA HPA:0460671 skin 1; melanocytes[≥Low] 5.29455828328591e-05 5378 93 67 0.720430107526882 0.0124581628858312
HPA HPA:0110222 cervix, uterine; squamous epithelial cells[≥Medium] 5.29455828328591e-05 3617 94 52 0.553191489361702 0.0143765551562068
HPA HPA:0250131 hippocampus; neuronal cells[≥Low] 5.29455828328591e-05 6101 92 72 0.782608695652174 0.0118013440419603
HPA HPA:0090163 cerebellum; Purkinje cells[High] 5.73484669685628e-05 1527 91 29 0.318681318681319 0.0189914865749836
HPA HPA:0170000 endometrium 2 6.07036192469795e-05 6755 67 58 0.865671641791045 0.00858623242042931
HPA HPA:0010000 adipose tissue 6.07036192469795e-05 3848 79 47 0.594936708860759 0.0122141372141372
HPA HPA:0010011 adipose tissue; adipocytes[≥Low] 6.07036192469795e-05 3848 79 47 0.594936708860759 0.0122141372141372
HPA HPA:0130051 colon; glandular cells[≥Low] 6.36516623021318e-05 7414 67 61 0.91044776119403 0.00822767736714324
HPA HPA:0270361 kidney; cells in tubules[≥Low] 6.48419500598387e-05 7652 67 62 0.925373134328358 0.00810245687401986
HPA HPA:0390053 prostate; glandular cells[High] 6.73147577097973e-05 1284 97 27 0.278350515463918 0.0210280373831776
HPA HPA:0100132 cerebral cortex; neuronal cells[≥Medium] 6.7853403646556e-05 4883 59 43 0.728813559322034 0.00880606184722507
HPA HPA:0600432 tonsil; germinal center cells[≥Medium] 7.46803865289457e-05 3988 94 55 0.585106382978723 0.0137913741223671
HPA HPA:0470000 skin 2 7.46803865289457e-05 6608 93 76 0.817204301075269 0.011501210653753
HPA HPA:0470681 skin 2; epidermal cells[≥Low] 7.46803865289457e-05 6608 93 76 0.817204301075269 0.011501210653753
HPA HPA:0300411 lung; macrophages[≥Low] 8.22484090695542e-05 6645 79 66 0.835443037974684 0.00993227990970655
HPA HPA:0160051 endometrium 1; glandular cells[≥Low] 8.37109517387787e-05 6663 64 55 0.859375 0.00825453999699835
HPA HPA:0170052 endometrium 2; glandular cells[≥Medium] 9.44702923905697e-05 4758 59 42 0.711864406779661 0.00882723833543506
HPA HPA:0540051 stomach 1; glandular cells[≥Low] 9.44702923905697e-05 7493 67 61 0.91044776119403 0.00814093153610036
HPA HPA:0400051 rectum; glandular cells[≥Low] 9.44702923905697e-05 7496 67 61 0.91044776119403 0.00813767342582711
HPA HPA:0530721 spleen; cells in white pulp[≥Low] 9.44702923905697e-05 4249 98 59 0.602040816326531 0.0138856201459167
HPA HPA:0540000 stomach 1 9.44702923905697e-05 7493 67 61 0.91044776119403 0.00814093153610036
HPA HPA:0400000 rectum 9.44702923905697e-05 7496 67 61 0.91044776119403 0.00813767342582711
HPA HPA:0060000 bronchus 9.62352012987899e-05 7277 67 60 0.895522388059702 0.00824515597086712
HPA HPA:0550053 stomach 2; glandular cells[High] 0.000107354324699206 2350 74 32 0.432432432432432 0.0136170212765957
HPA HPA:0300412 lung; macrophages[≥Medium] 0.000120394774373393 4732 94 61 0.648936170212766 0.0128909551986475
HPA HPA:0080000 caudate 0.000137421898216332 6817 61 53 0.868852459016393 0.00777468094469708
HPA HPA:0030000 appendix 0.000157826503809229 7584 67 61 0.91044776119403 0.00804324894514768
HPA HPA:0570813 testis; spermatogonia cells[High] 0.000158372580005467 1281 97 26 0.268041237113402 0.0202966432474629
HPA HPA:0480051 small intestine; glandular cells[≥Low] 0.000162666584578113 7593 67 61 0.91044776119403 0.008033715264059
HPA HPA:0480000 small intestine 0.000162666584578113 7593 67 61 0.91044776119403 0.008033715264059
HPA HPA:0350471 pancreas; exocrine glandular cells[≥Low] 0.000171724021114071 6778 94 77 0.819148936170213 0.011360283269401
HPA HPA:0100131 cerebral cortex; neuronal cells[≥Low] 0.000181879236034692 6566 67 56 0.835820895522388 0.00852878464818763
HPA HPA:0190221 esophagus; squamous epithelial cells[≥Low] 0.000186284453930836 6524 94 75 0.797872340425532 0.0114960147148988
HPA HPA:0190000 esophagus 0.000186284453930836 6524 94 75 0.797872340425532 0.0114960147148988
HPA HPA:0050053 breast; glandular cells[High] 0.000189407070867744 1299 97 26 0.268041237113402 0.0200153964588145
HPA HPA:0350473 pancreas; exocrine glandular cells[High] 0.000194645851019051 1879 89 31 0.348314606741573 0.0164981373070782
HPA HPA:0360000 parathyroid gland 0.000196363480603533 5767 94 69 0.734042553191489 0.0119646263221779
HPA HPA:0360051 parathyroid gland; glandular cells[≥Low] 0.000196363480603533 5767 94 69 0.734042553191489 0.0119646263221779
HPA HPA:0060103 bronchus; respiratory epithelial cells[High] 0.000214537575584844 1890 97 33 0.34020618556701 0.0174603174603175
HPA HPA:0460661 skin 1; keratinocytes[≥Low] 0.000233192893146265 6051 67 53 0.791044776119403 0.00875888282928442
HPA HPA:0210053 fallopian tube; glandular cells[High] 0.000233192893146265 1728 97 31 0.319587628865979 0.0179398148148148
HPA HPA:0550051 stomach 2; glandular cells[≥Low] 0.00024347275713804 7453 67 60 0.895522388059702 0.00805044948342949
HPA HPA:0550000 stomach 2 0.00024347275713804 7453 67 60 0.895522388059702 0.00805044948342949
HPA HPA:0050091 breast; myoepithelial cells[≥Low] 0.000247867654973509 5551 86 62 0.720930232558139 0.0111691587101423
HPA HPA:0050052 breast; glandular cells[≥Medium] 0.000256740184348432 4971 94 62 0.659574468085106 0.0124723395695031
HPA HPA:0160000 endometrium 1 0.00025702527964644 6894 64 55 0.859375 0.00797795184218161
HPA HPA:0530000 spleen 0.00025702527964644 5756 59 46 0.779661016949153 0.00799166087560806
HPA HPA:0600441 tonsil; non-germinal center cells[≥Low] 0.000258928264929038 5966 59 47 0.796610169491525 0.00787797519275897
HPA HPA:0590052 thyroid gland; glandular cells[≥Medium] 0.000265679771634291 5454 94 66 0.702127659574468 0.0121012101210121
HPA HPA:0241101 heart muscle; cardiomyocytes[≥Low] 0.000267620413664478 6188 59 48 0.813559322033898 0.00775694893341952
HPA HPA:0240000 heart muscle 0.000267620413664478 6188 59 48 0.813559322033898 0.00775694893341952
HPA HPA:0050051 breast; glandular cells[≥Low] 0.000271401969083685 6659 67 56 0.835820895522388 0.00840967112179006
HPA HPA:0330222 oral mucosa; squamous epithelial cells[≥Medium] 0.00028188734776666 4254 93 55 0.591397849462366 0.0129290079924777
HPA HPA:0510000 soft tissue 2 0.000283885891755064 5082 77 53 0.688311688311688 0.0104289649744195
HPA HPA:0270000 kidney 0.000283885891755064 7944 67 62 0.925373134328358 0.00780463242698892
HPA HPA:0250000 hippocampus 0.000314968590138146 6678 92 74 0.804347826086957 0.0110811620245583
HPA HPA:0210000 fallopian tube 0.000321460493780292 7302 67 59 0.880597014925373 0.00807997808819502
HPA HPA:0100121 cerebral cortex; glial cells[≥Low] 0.000346193564231294 4804 92 59 0.641304347826087 0.0122814321398834
HPA HPA:0110000 cervix, uterine 0.000363796628439533 6778 94 76 0.808510638297872 0.0112127471230451
HPA HPA:0620000 vagina 0.000461585858444168 5868 93 68 0.731182795698925 0.0115882753919564
HPA HPA:0620221 vagina; squamous epithelial cells[≥Low] 0.000461585858444168 5868 93 68 0.731182795698925 0.0115882753919564
HPA HPA:0300000 lung 0.00046450471824207 7163 67 58 0.865671641791045 0.00809716599190283
HPA HPA:0170251 endometrium 2; cells in endometrial stroma[≥Low] 0.00049942165340911 3410 92 46 0.5 0.0134897360703812
HPA HPA:0350000 pancreas 0.000513721677381392 7242 94 79 0.840425531914894 0.0109085887876277
HPA HPA:0600000 tonsil 0.000555403026415089 7618 67 60 0.895522388059702 0.00787608296140719
HPA HPA:0600222 tonsil; squamous epithelial cells[≥Medium] 0.000559966373795104 4851 67 45 0.671641791044776 0.00927643784786642
HPA HPA:0090162 cerebellum; Purkinje cells[≥Medium] 0.000568297030130145 4047 59 36 0.610169491525424 0.00889547813194959
HPA HPA:0620222 vagina; squamous epithelial cells[≥Medium] 0.000665564669991353 3945 93 51 0.548387096774194 0.0129277566539924
HPA HPA:0320000 nasopharynx 0.000675685937214406 7035 67 57 0.850746268656716 0.00810234541577825
HPA HPA:0130241 colon; peripheral nerve/ganglion[≥Low] 0.000682376998856686 5037 40 30 0.75 0.00595592614651578
HPA HPA:0570731 testis; Leydig cells[≥Low] 0.000689860764282542 7041 67 57 0.850746268656716 0.00809544098849595
HPA HPA:0600221 tonsil; squamous epithelial cells[≥Low] 0.000728264760825451 6518 78 62 0.794871794871795 0.00951212028229518
HPA HPA:0530711 spleen; cells in red pulp[≥Low] 0.000743312491250567 5195 59 42 0.711864406779661 0.00808469682386911
HPA HPA:0180053 epididymis; glandular cells[High] 0.000780034718391313 1779 97 30 0.309278350515464 0.0168634064080944
HPA HPA:0510701 soft tissue 2; peripheral nerve[≥Low] 0.000810385098968708 3100 75 36 0.48 0.0116129032258065
HPA HPA:0250121 hippocampus; glial cells[≥Low] 0.000820371458973007 4033 58 35 0.603448275862069 0.00867840317381602
HPA HPA:0301171 lung; alveolar cells[≥Low] 0.000838450154811743 5028 66 45 0.681818181818182 0.00894988066825776
HPA HPA:0090191 cerebellum; cells in molecular layer[≥Low] 0.000972170017840616 4336 57 36 0.631578947368421 0.00830258302583026
HPA HPA:0130000 colon 0.00102349545448849 7959 67 61 0.91044776119403 0.00766427943208946
HPA HPA:0440000 skeletal muscle 0.00102361996801768 5762 93 66 0.709677419354839 0.011454356126345
HPA HPA:0440341 skeletal muscle; myocytes[≥Low] 0.00102361996801768 5762 93 66 0.709677419354839 0.011454356126345
HPA HPA:0110221 cervix, uterine; squamous epithelial cells[≥Low] 0.00102361996801768 5325 94 63 0.670212765957447 0.011830985915493
HPA HPA:0090161 cerebellum; Purkinje cells[≥Low] 0.00102361996801768 5460 59 43 0.728813559322034 0.00787545787545788
HPA HPA:0220051 gallbladder; glandular cells[≥Low] 0.00108969523306916 7503 66 58 0.878787878787879 0.0077302412368386
HPA HPA:0220000 gallbladder 0.00108969523306916 7503 66 58 0.878787878787879 0.0077302412368386
HPA HPA:0080121 caudate; glial cells[≥Low] 0.00114101751621196 4464 58 37 0.637931034482759 0.00828853046594982
HPA HPA:0380521 placenta; trophoblastic cells[≥Low] 0.00114763234972041 6388 67 53 0.791044776119403 0.00829680651221039
HPA HPA:0010012 adipose tissue; adipocytes[≥Medium] 0.00146342233115861 2168 26 13 0.5 0.00599630996309963
HPA HPA:0300413 lung; macrophages[High] 0.00148090326880943 1224 48 14 0.291666666666667 0.011437908496732
HPA HPA:0050000 breast 0.00155468412645221 7026 94 76 0.808510638297872 0.0108169655565044
HPA HPA:0160251 endometrium 1; cells in endometrial stroma[≥Low] 0.00163860827807284 3962 98 52 0.530612244897959 0.0131246845027764
HPA HPA:0180051 epididymis; glandular cells[≥Low] 0.00164175961844242 7171 94 77 0.819148936170213 0.0107376934876586
HPA HPA:0180000 epididymis 0.00164175961844242 7171 94 77 0.819148936170213 0.0107376934876586
HPA HPA:0380522 placenta; trophoblastic cells[≥Medium] 0.0017756448906254 5074 94 60 0.638297872340426 0.0118249901458415
HPA HPA:0050012 breast; adipocytes[≥Medium] 0.0017756448906254 1445 97 25 0.257731958762887 0.0173010380622837
HPA HPA:0090000 cerebellum 0.0018589867649393 7058 59 50 0.847457627118644 0.00708415981864551
HPA HPA:0100212 cerebral cortex; neuropil[≥Medium] 0.0018589867649393 2588 79 32 0.40506329113924 0.0123647604327666
HPA HPA:0570803 testis; sertoli cells[High] 0.00216730186515377 536 97 13 0.134020618556701 0.0242537313432836
HPA HPA:0030071 appendix; lymphoid tissue[≥Low] 0.00265831370068683 4976 93 58 0.623655913978495 0.0116559485530547
HPA HPA:0460000 skin 1 0.00265831370068683 6938 67 55 0.82089552238806 0.00792735658691266
HPA HPA:0030072 appendix; lymphoid tissue[≥Medium] 0.00267913146331922 3131 98 43 0.438775510204082 0.0137336314276589
HPA HPA:0100000 cerebral cortex 0.00270186373285227 7943 67 60 0.895522388059702 0.00755382097444291
HPA HPA:0301172 lung; alveolar cells[≥Medium] 0.0027795547386215 2863 5 5 1 0.00174641983932937
HPA HPA:0080133 caudate; neuronal cells[High] 0.00282739923404209 1059 92 19 0.206521739130435 0.0179414542020774
HPA HPA:0130202 colon; endothelial cells[≥Medium] 0.00291648351573988 3655 93 46 0.494623655913978 0.0125854993160055
HPA HPA:0420053 salivary gland; glandular cells[High] 0.00296523520849989 1418 97 24 0.247422680412371 0.0169252468265162
HPA HPA:0330000 oral mucosa 0.00327590428740802 6102 93 67 0.720430107526882 0.0109800065552278
HPA HPA:0330221 oral mucosa; squamous epithelial cells[≥Low] 0.00327590428740802 6102 93 67 0.720430107526882 0.0109800065552278
HPA HPA:0090183 cerebellum; cells in granular layer[High] 0.00335713045559176 709 69 12 0.173913043478261 0.0169252468265162
HPA HPA:0530723 spleen; cells in white pulp[High] 0.00341377731489841 811 69 13 0.188405797101449 0.0160295930949445
HPA HPA:0510651 soft tissue 2; fibroblasts[≥Low] 0.00341377731489841 4037 77 42 0.545454545454545 0.0104037651721575
HPA HPA:0570812 testis; spermatogonia cells[≥Medium] 0.00362330030193856 2285 92 32 0.347826086956522 0.0140043763676149
HPA HPA:0170053 endometrium 2; glandular cells[High] 0.00394435073692595 1282 97 22 0.22680412371134 0.0171606864274571
HPA HPA:0460642 skin 1; Langerhans[≥Medium] 0.00420053655000675 3123 92 40 0.434782608695652 0.0128081972462376
HPA HPA:0100201 cerebral cortex; endothelial cells[≥Low] 0.0042811933413832 4556 76 45 0.592105263157895 0.00987708516242318
HPA HPA:0130201 colon; endothelial cells[≥Low] 0.00434263799530449 5671 93 63 0.67741935483871 0.0111091518250749
HPA HPA:0050092 breast; myoepithelial cells[≥Medium] 0.0043696665543089 3700 40 23 0.575 0.00621621621621622
HPA HPA:0490000 smooth muscle 0.00453594552119059 5324 93 60 0.645161290322581 0.0112697220135237
HPA HPA:0490691 smooth muscle; smooth muscle cells[≥Low] 0.00453594552119059 5324 93 60 0.645161290322581 0.0112697220135237
HPA HPA:0090951 cerebellum; Purkinje cells - dendrites[≥Low] 0.00453594552119059 230 86 7 0.0813953488372093 0.0304347826086957
HPA HPA:0040082 bone marrow; hematopoietic cells[≥Medium] 0.00484266840859066 4126 66 37 0.560606060606061 0.00896752302472128
HPA HPA:0310443 lymph node; non-germinal center cells[High] 0.00525173191493165 1169 40 11 0.275 0.00940975192472198
HPA HPA:0380000 placenta 0.00541559845109644 7321 59 50 0.847457627118644 0.0068296680781314
HPA HPA:0600433 tonsil; germinal center cells[High] 0.0055651521333804 1179 40 11 0.275 0.00932994062765055
HPA HPA:0080122 caudate; glial cells[≥Medium] 0.00605472980735347 2230 53 20 0.377358490566038 0.00896860986547085
HPA HPA:0190223 esophagus; squamous epithelial cells[High] 0.00613466563167474 1596 92 24 0.260869565217391 0.0150375939849624
HPA HPA:0100122 cerebral cortex; glial cells[≥Medium] 0.00621900969112007 2588 59 24 0.406779661016949 0.00927357032457496
HPA HPA:0380512 placenta; decidual cells[≥Medium] 0.00626630706137084 3463 53 27 0.509433962264151 0.00779670805659833
HPA HPA:0600442 tonsil; non-germinal center cells[≥Medium] 0.00626630706137084 4079 61 34 0.557377049180328 0.00833537631772493
HPA HPA:0310441 lymph node; non-germinal center cells[≥Low] 0.006447172311059 5915 59 43 0.728813559322034 0.00726965342349958
HPA HPA:0250122 hippocampus; glial cells[≥Medium] 0.0066052728852563 1926 53 18 0.339622641509434 0.00934579439252336
HPA HPA:0090181 cerebellum; cells in granular layer[≥Low] 0.00666627287678177 4438 65 38 0.584615384615385 0.00856241550247859
HPA HPA:0340452 ovary; follicle cells[≥Medium] 0.00693680141352906 2183 44 17 0.386363636363636 0.00778744846541457
HPA HPA:0460651 skin 1; fibroblasts[≥Low] 0.00718298164675808 4726 89 52 0.584269662921348 0.0110029623360135
HPA HPA:0570761 testis; pachytene spermatocytes[≥Low] 0.00744168680069709 2077 39 15 0.384615384615385 0.00722195474241695
HPA HPA:0110053 cervix, uterine; glandular cells[High] 0.00781903726573383 1135 62 14 0.225806451612903 0.0123348017621145
HPA HPA:0570751 testis; elongated or late spermatids[≥Low] 0.00838703272346394 1798 89 25 0.280898876404494 0.0139043381535039
HPA HPA:0090921 cerebellum; GLUC cells - cytoplasm/membrane[≥Low] 0.00845573672165346 197 86 6 0.0697674418604651 0.0304568527918782
HPA HPA:0570811 testis; spermatogonia cells[≥Low] 0.00845573672165346 2732 92 35 0.380434782608696 0.0128111273792094
HPA HPA:0050093 breast; myoepithelial cells[High] 0.00862959735792387 798 97 15 0.154639175257732 0.018796992481203
HPA HPA:0310431 lymph node; germinal center cells[≥Low] 0.00874117666697396 4935 62 39 0.629032258064516 0.00790273556231003
HPA HPA:0460652 skin 1; fibroblasts[≥Medium] 0.00892125008826841 3304 67 31 0.462686567164179 0.00938256658595642
HPA HPA:0351183 pancreas; pancreatic endocrine cells[High] 0.00915456814989576 758 24 6 0.25 0.0079155672823219
HPA HPA:0320103 nasopharynx; respiratory epithelial cells[High] 0.00959177030312732 1844 97 27 0.278350515463918 0.0146420824295011
HPA HPA:0380523 placenta; trophoblastic cells[High] 0.010377731603145 1998 27 11 0.407407407407407 0.00550550550550551
HPA HPA:0130242 colon; peripheral nerve/ganglion[≥Medium] 0.0104124556370677 3406 92 41 0.445652173913043 0.0120375807398708
HPA HPA:0090952 cerebellum; Purkinje cells - dendrites[≥Medium] 0.011083587390002 210 86 6 0.0697674418604651 0.0285714285714286
HPA HPA:0100202 cerebral cortex; endothelial cells[≥Medium] 0.0124627958141121 2425 98 33 0.336734693877551 0.0136082474226804
HPA HPA:0500652 soft tissue 1; fibroblasts[≥Medium] 0.0132664233490411 2649 58 23 0.396551724137931 0.00868252170630427
HPA HPA:0340453 ovary; follicle cells[High] 0.0132664233490411 579 24 5 0.208333333333333 0.00863557858376511
HPA HPA:0090942 cerebellum; Purkinje cells - cytoplasm/membrane[≥Medium] 0.0148643442397066 368 86 8 0.0930232558139535 0.0217391304347826
HPA HPA:0040000 bone marrow 0.0149738796190948 6349 94 67 0.712765957446808 0.0105528429673964
HPA HPA:0040081 bone marrow; hematopoietic cells[≥Low] 0.0149738796190948 6349 94 67 0.712765957446808 0.0105528429673964
HPA HPA:0090941 cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] 0.0151083066377404 448 86 9 0.104651162790698 0.0200892857142857
HPA HPA:0500651 soft tissue 1; fibroblasts[≥Low] 0.0151083066377404 4156 94 48 0.51063829787234 0.0115495668912416
HPA HPA:0340000 ovary 0.0156561802186426 5298 13 11 0.846153846153846 0.00207625519063798
HPA HPA:0310000 lymph node 0.0163363326740044 6374 62 46 0.741935483870968 0.00721681832444305
HPA HPA:0090923 cerebellum; GLUC cells - cytoplasm/membrane[High] 0.016764275034779 107 86 4 0.0465116279069767 0.0373831775700935
HPA HPA:0570000 testis 0.016764275034779 8790 67 62 0.925373134328358 0.00705346985210466
HPA HPA:0160252 endometrium 1; cells in endometrial stroma[≥Medium] 0.0167912318305532 2142 76 24 0.315789473684211 0.0112044817927171
HPA HPA:0340461 ovary; ovarian stroma cells[≥Low] 0.0171530766674841 3894 98 47 0.479591836734694 0.0120698510529019
HPA HPA:0380511 placenta; decidual cells[≥Low] 0.0175144136768756 4716 53 32 0.60377358490566 0.00678541136556404
HPA HPA:0310432 lymph node; germinal center cells[≥Medium] 0.0202491372843561 3209 98 40 0.408163265306122 0.0124649423496416
HPA HPA:0510652 soft tissue 2; fibroblasts[≥Medium] 0.0202688462150696 2543 97 33 0.34020618556701 0.0129767990562328
HPA HPA:0090922 cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] 0.0219747673481525 179 86 5 0.0581395348837209 0.0279329608938547
HPA HPA:0530712 spleen; cells in red pulp[≥Medium] 0.0221055934984777 3049 59 25 0.423728813559322 0.00819940964250574
HPA HPA:0170252 endometrium 2; cells in endometrial stroma[≥Medium] 0.0221199210341381 1722 4 3 0.75 0.00174216027874564
HPA HPA:0310433 lymph node; germinal center cells[High] 0.0238066016067264 908 97 15 0.154639175257732 0.0165198237885463
HPA HPA:0600443 tonsil; non-germinal center cells[High] 0.0238128083304178 1271 40 10 0.25 0.00786782061369001
HPA HPA:0590053 thyroid gland; glandular cells[High] 0.0238662172833388 1804 97 25 0.257731958762887 0.0138580931263858
HPA HPA:0270351 kidney; cells in glomeruli[≥Low] 0.024930435455306 5033 66 40 0.606060606060606 0.00794754619511226
HPA HPA:0620223 vagina; squamous epithelial cells[High] 0.0258265164297947 1091 97 17 0.175257731958763 0.0155820348304308
HPA HPA:0570762 testis; pachytene spermatocytes[≥Medium] 0.0263863417307342 1658 23 8 0.347826086956522 0.00482509047044632
HPA HPA:0380513 placenta; decidual cells[High] 0.0291510958063442 1144 59 12 0.203389830508475 0.0104895104895105
HPA HPA:0100123 cerebral cortex; glial cells[High] 0.0315543615360422 683 35 6 0.171428571428571 0.00878477306002928
HPA HPA:0490692 smooth muscle; smooth muscle cells[≥Medium] 0.0323724343957832 3038 7 5 0.714285714285714 0.00164581961816985
HPA HPA:0510702 soft tissue 2; peripheral nerve[≥Medium] 0.033757116160446 1477 92 20 0.217391304347826 0.01354096140826
HPA HPA:0301173 lung; alveolar cells[High] 0.0381612686841021 778 24 5 0.208333333333333 0.006426735218509
HPA HPA:0500000 soft tissue 1 0.0391058742005865 5242 67 41 0.611940298507463 0.00782144219763449
HPA HPA:0470683 skin 2; epidermal cells[High] 0.0431655163053089 1346 97 19 0.195876288659794 0.0141158989598811
HPA HPA:0510111 soft tissue 2; chondrocytes[≥Low] 0.0431655163053089 1055 83 14 0.168674698795181 0.0132701421800948
HPA HPA:0500112 soft tissue 1; chondrocytes[≥Medium] 0.0439395828675198 1395 10 4 0.4 0.0028673835125448
HPA HPA:0090971 cerebellum; granular cells - cytoplasm/membrane[≥Low] 0.0444122331302022 297 86 6 0.0697674418604651 0.0202020202020202
HPA HPA:0570783 testis; preleptotene spermatocytes[High] 0.0462251321091381 603 92 10 0.108695652173913 0.0165837479270315
KEGG KEGG:05012 Parkinson disease 1.07516204466965e-29 249 96 37 0.385416666666667 0.14859437751004
KEGG KEGG:05020 Prion disease 1.75544197131963e-28 273 96 37 0.385416666666667 0.135531135531136
KEGG KEGG:05016 Huntington disease 8.31699907695659e-27 306 96 37 0.385416666666667 0.120915032679739
KEGG KEGG:05010 Alzheimer disease 4.01465635145926e-25 369 96 38 0.395833333333333 0.102981029810298
KEGG KEGG:05014 Amyotrophic lateral sclerosis 4.3087649084587e-25 363 98 38 0.387755102040816 0.104683195592287
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 2.80624432579612e-21 475 96 38 0.395833333333333 0.08
KEGG KEGG:03050 Proteasome 8.17770518176844e-21 46 96 17 0.177083333333333 0.369565217391304
KEGG KEGG:00190 Oxidative phosphorylation 7.14869835638826e-19 133 71 20 0.28169014084507 0.150375939849624
KEGG KEGG:04932 Non-alcoholic fatty liver disease 1.70419204575619e-16 150 71 19 0.267605633802817 0.126666666666667
KEGG KEGG:05415 Diabetic cardiomyopathy 1.70419204575619e-16 203 71 21 0.295774647887324 0.103448275862069
KEGG KEGG:00020 Citrate cycle (TCA cycle) 1.55393698659189e-14 30 79 11 0.139240506329114 0.366666666666667
KEGG KEGG:01200 Carbon metabolism 9.56591430314534e-14 116 79 16 0.20253164556962 0.137931034482759
KEGG KEGG:04714 Thermogenesis 4.39210833303119e-13 232 71 19 0.267605633802817 0.0818965517241379
KEGG KEGG:05017 Spinocerebellar ataxia 3.79575522783676e-12 142 96 17 0.177083333333333 0.119718309859155
KEGG KEGG:04723 Retrograde endocannabinoid signaling 6.85622645149784e-12 148 69 15 0.217391304347826 0.101351351351351
KEGG KEGG:01100 Metabolic pathways 2.44108935783285e-11 1490 79 42 0.531645569620253 0.0281879194630872
KEGG KEGG:00620 Pyruvate metabolism 4.33346040518296e-08 47 74 8 0.108108108108108 0.170212765957447
KEGG KEGG:00480 Glutathione metabolism 4.80189194557083e-06 56 27 5 0.185185185185185 0.0892857142857143
KEGG KEGG:00982 Drug metabolism - cytochrome P450 1.29899728355038e-05 69 27 5 0.185185185185185 0.072463768115942
KEGG KEGG:00980 Metabolism of xenobiotics by cytochrome P450 1.74858814797528e-05 74 27 5 0.185185185185185 0.0675675675675676
KEGG KEGG:05204 Chemical carcinogenesis 2.60641655058175e-05 81 27 5 0.185185185185185 0.0617283950617284
KEGG KEGG:01524 Platinum drug resistance 0.000353669485226046 72 27 4 0.148148148148148 0.0555555555555556
KEGG KEGG:00983 Drug metabolism - other enzymes 0.000486155272271274 79 27 4 0.148148148148148 0.0506329113924051
KEGG KEGG:00010 Glycolysis / Gluconeogenesis 0.00100823591614398 67 70 5 0.0714285714285714 0.0746268656716418
KEGG KEGG:05418 Fluid shear stress and atherosclerosis 0.00375804191603857 138 27 4 0.148148148148148 0.0289855072463768
KEGG KEGG:00280 Valine, leucine and isoleucine degradation 0.00388604577830034 48 78 4 0.0512820512820513 0.0833333333333333
KEGG KEGG:05225 Hepatocellular carcinoma 0.00688127384702281 166 27 4 0.148148148148148 0.0240963855421687
KEGG KEGG:05169 Epstein-Barr virus infection 0.00772756988267809 198 96 8 0.0833333333333333 0.0404040404040404
KEGG KEGG:00410 beta-Alanine metabolism 0.00887985904078362 30 78 3 0.0384615384615385 0.1
KEGG KEGG:00640 Propanoate metabolism 0.0119064530728444 34 78 3 0.0384615384615385 0.0882352941176471
KEGG KEGG:00071 Fatty acid degradation 0.0123316603942618 43 63 3 0.0476190476190476 0.0697674418604651
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 3.9728499631424e-26 174 91 28 0.307692307692308 0.160919540229885
REAC REAC:R-HSA-1430728 Metabolism 1.30335587467142e-22 2070 84 60 0.714285714285714 0.0289855072463768
REAC REAC:R-HSA-611105 Respiratory electron transport 5.03325088296825e-22 100 91 21 0.230769230769231 0.21
REAC REAC:R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 2.10408130189675e-21 51 96 17 0.177083333333333 0.333333333333333
REAC REAC:R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 2.10408130189675e-21 50 96 17 0.177083333333333 0.34
REAC REAC:R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 2.10408130189675e-21 52 96 17 0.177083333333333 0.326923076923077
REAC REAC:R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 2.10408130189675e-21 52 96 17 0.177083333333333 0.326923076923077
REAC REAC:R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 2.10408130189675e-21 52 96 17 0.177083333333333 0.326923076923077
REAC REAC:R-HSA-180534 Vpu mediated degradation of CD4 2.10408130189675e-21 52 96 17 0.177083333333333 0.326923076923077
REAC REAC:R-HSA-69610 p53-Independent DNA Damage Response 2.10408130189675e-21 52 96 17 0.177083333333333 0.326923076923077
REAC REAC:R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 2.10408130189675e-21 52 96 17 0.177083333333333 0.326923076923077
REAC REAC:R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 2.10408130189675e-21 50 96 17 0.177083333333333 0.34
REAC REAC:R-HSA-180585 Vif-mediated degradation of APOBEC3G 2.4605328580721e-21 53 96 17 0.177083333333333 0.320754716981132
REAC REAC:R-HSA-169911 Regulation of Apoptosis 2.4605328580721e-21 53 96 17 0.177083333333333 0.320754716981132
REAC REAC:R-HSA-9604323 Negative regulation of NOTCH4 signaling 2.4605328580721e-21 53 96 17 0.177083333333333 0.320754716981132
REAC REAC:R-HSA-8941858 Regulation of RUNX3 expression and activity 3.14605730757021e-21 54 96 17 0.177083333333333 0.314814814814815
REAC REAC:R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 3.14605730757021e-21 54 96 17 0.177083333333333 0.314814814814815
REAC REAC:R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 3.84297470211765e-21 55 96 17 0.177083333333333 0.309090909090909
REAC REAC:R-HSA-4641257 Degradation of AXIN 3.84297470211765e-21 55 96 17 0.177083333333333 0.309090909090909
REAC REAC:R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 3.84297470211765e-21 55 96 17 0.177083333333333 0.309090909090909
REAC REAC:R-HSA-5362768 Hh mutants are degraded by ERAD 5.21800288507557e-21 56 96 17 0.177083333333333 0.303571428571429
REAC REAC:R-HSA-69541 Stabilization of p53 6.74082569392695e-21 57 96 17 0.177083333333333 0.298245614035088
REAC REAC:R-HSA-4641258 Degradation of DVL 6.74082569392695e-21 57 96 17 0.177083333333333 0.298245614035088
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 7.86368757814119e-21 124 91 21 0.230769230769231 0.169354838709677
REAC REAC:R-HSA-351202 Metabolism of polyamines 8.71058476708773e-21 58 96 17 0.177083333333333 0.293103448275862
REAC REAC:R-HSA-5387390 Hh mutants abrogate ligand secretion 1.08476097053207e-20 59 96 17 0.177083333333333 0.288135593220339
REAC REAC:R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 1.08476097053207e-20 59 96 17 0.177083333333333 0.288135593220339
REAC REAC:R-HSA-5676590 NIK-->noncanonical NF-kB signaling 1.08476097053207e-20 59 96 17 0.177083333333333 0.288135593220339
REAC REAC:R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 1.27515438628627e-20 60 96 17 0.177083333333333 0.283333333333333
REAC REAC:R-HSA-5610783 Degradation of GLI2 by the proteasome 1.27515438628627e-20 60 96 17 0.177083333333333 0.283333333333333
REAC REAC:R-HSA-5610780 Degradation of GLI1 by the proteasome 1.27515438628627e-20 60 96 17 0.177083333333333 0.283333333333333
REAC REAC:R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 1.27515438628627e-20 60 96 17 0.177083333333333 0.283333333333333
REAC REAC:R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 1.27515438628627e-20 60 96 17 0.177083333333333 0.283333333333333
REAC REAC:R-HSA-5678895 Defective CFTR causes cystic fibrosis 1.70363507664925e-20 61 96 17 0.177083333333333 0.278688524590164
REAC REAC:R-HSA-6799198 Complex I biogenesis 3.06671113062636e-20 55 69 15 0.217391304347826 0.272727272727273
REAC REAC:R-HSA-4608870 Asymmetric localization of PCP proteins 3.93732614206725e-20 64 96 17 0.177083333333333 0.265625
REAC REAC:R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 3.93732614206725e-20 64 96 17 0.177083333333333 0.265625
REAC REAC:R-HSA-5358346 Hedgehog ligand biogenesis 5.15456978947209e-20 65 96 17 0.177083333333333 0.261538461538462
REAC REAC:R-HSA-69563 p53-Dependent G1 DNA Damage Response 6.38911341631478e-20 66 96 17 0.177083333333333 0.257575757575758
REAC REAC:R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 6.38911341631478e-20 66 96 17 0.177083333333333 0.257575757575758
REAC REAC:R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 6.38911341631478e-20 66 96 17 0.177083333333333 0.257575757575758
REAC REAC:R-HSA-1169091 Activation of NF-kappaB in B cells 8.10515204749222e-20 67 96 17 0.177083333333333 0.253731343283582
REAC REAC:R-HSA-5658442 Regulation of RAS by GAPs 8.10515204749222e-20 67 96 17 0.177083333333333 0.253731343283582
REAC REAC:R-HSA-69615 G1/S DNA Damage Checkpoints 1.00302252773644e-19 68 96 17 0.177083333333333 0.25
REAC REAC:R-HSA-68867 Assembly of the pre-replicative complex 1.00302252773644e-19 68 96 17 0.177083333333333 0.25
REAC REAC:R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 1.00302252773644e-19 68 96 17 0.177083333333333 0.25
REAC REAC:R-HSA-8948751 Regulation of PTEN stability and activity 1.29335087092233e-19 69 96 17 0.177083333333333 0.246376811594203
REAC REAC:R-HSA-8939902 Regulation of RUNX2 expression and activity 2.12375382620984e-19 71 96 17 0.177083333333333 0.23943661971831
REAC REAC:R-HSA-68949 Orc1 removal from chromatin 2.12375382620984e-19 71 96 17 0.177083333333333 0.23943661971831
REAC REAC:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 2.55236884437903e-19 86 97 18 0.185567010309278 0.209302325581395
REAC REAC:R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 3.36666569214276e-19 73 96 17 0.177083333333333 0.232876712328767
REAC REAC:R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 3.36666569214276e-19 73 96 17 0.177083333333333 0.232876712328767
REAC REAC:R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 4.17893243588223e-19 74 96 17 0.177083333333333 0.22972972972973
REAC REAC:R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 4.17893243588223e-19 74 96 17 0.177083333333333 0.22972972972973
REAC REAC:R-HSA-1234174 Cellular response to hypoxia 5.26778922486558e-19 75 96 17 0.177083333333333 0.226666666666667
REAC REAC:R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 6.61703031140316e-19 76 96 17 0.177083333333333 0.223684210526316
REAC REAC:R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 8.14068434216702e-19 77 96 17 0.177083333333333 0.220779220779221
REAC REAC:R-HSA-5619084 ABC transporter disorders 8.14068434216702e-19 77 96 17 0.177083333333333 0.220779220779221
REAC REAC:R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 1.28538434711656e-18 79 96 17 0.177083333333333 0.215189873417722
REAC REAC:R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 1.59360565929411e-18 80 96 17 0.177083333333333 0.2125
REAC REAC:R-HSA-9013694 Signaling by NOTCH4 1.93795156440843e-18 81 96 17 0.177083333333333 0.209876543209877
REAC REAC:R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 1.93795156440843e-18 81 96 17 0.177083333333333 0.209876543209877
REAC REAC:R-HSA-69202 Cyclin E associated events during G1/S transition 2.8910138856795e-18 83 96 17 0.177083333333333 0.204819277108434
REAC REAC:R-HSA-195253 Degradation of beta-catenin by the destruction complex 2.8910138856795e-18 83 96 17 0.177083333333333 0.204819277108434
REAC REAC:R-HSA-1236974 ER-Phagosome pathway 2.8910138856795e-18 83 96 17 0.177083333333333 0.204819277108434
REAC REAC:R-HSA-5632684 Hedgehog 'on' state 4.26935785632231e-18 85 96 17 0.177083333333333 0.2
REAC REAC:R-HSA-69002 DNA Replication Pre-Initiation 4.26935785632231e-18 85 96 17 0.177083333333333 0.2
REAC REAC:R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 4.26935785632231e-18 85 96 17 0.177083333333333 0.2
REAC REAC:R-HSA-453276 Regulation of mitotic cell cycle 7.79393766891656e-18 88 96 17 0.177083333333333 0.193181818181818
REAC REAC:R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 7.79393766891656e-18 88 96 17 0.177083333333333 0.193181818181818
REAC REAC:R-HSA-5687128 MAPK6/MAPK4 signaling 9.43082994322922e-18 89 96 17 0.177083333333333 0.191011235955056
REAC REAC:R-HSA-69052 Switching of origins to a post-replicative state 1.38993993139656e-17 91 96 17 0.177083333333333 0.186813186813187
REAC REAC:R-HSA-4086400 PCP/CE pathway 1.64709455929525e-17 92 96 17 0.177083333333333 0.184782608695652
REAC REAC:R-HSA-5689603 UCH proteinases 1.64709455929525e-17 92 96 17 0.177083333333333 0.184782608695652
REAC REAC:R-HSA-8878159 Transcriptional regulation by RUNX3 2.36174411211666e-17 94 96 17 0.177083333333333 0.180851063829787
REAC REAC:R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 2.36174411211666e-17 94 96 17 0.177083333333333 0.180851063829787
REAC REAC:R-HSA-5607764 CLEC7A (Dectin-1) signaling 4.09443127996273e-17 97 96 17 0.177083333333333 0.175257731958763
REAC REAC:R-HSA-202424 Downstream TCR signaling 4.85539625544936e-17 98 96 17 0.177083333333333 0.173469387755102
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 5.74655064253591e-17 99 96 17 0.177083333333333 0.171717171717172
REAC REAC:R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 6.78828001172824e-17 100 96 17 0.177083333333333 0.17
REAC REAC:R-HSA-9020702 Interleukin-1 signaling 8.00387126312923e-17 101 96 17 0.177083333333333 0.168316831683168
REAC REAC:R-HSA-382556 ABC-family proteins mediated transport 1.12015272341362e-16 103 96 17 0.177083333333333 0.16504854368932
REAC REAC:R-HSA-162909 Host Interactions of HIV factors 1.50162782186659e-16 125 96 18 0.1875 0.144
REAC REAC:R-HSA-5610787 Hedgehog 'off' state 5.60317930104116e-16 113 96 17 0.177083333333333 0.150442477876106
REAC REAC:R-HSA-8878166 Transcriptional regulation by RUNX2 1.18010312401867e-15 118 96 17 0.177083333333333 0.144067796610169
REAC REAC:R-HSA-202403 TCR signaling 1.54486082018955e-15 120 96 17 0.177083333333333 0.141666666666667
REAC REAC:R-HSA-69239 Synthesis of DNA 1.54486082018955e-15 120 96 17 0.177083333333333 0.141666666666667
REAC REAC:R-HSA-69306 DNA Replication 4.67004836961717e-15 128 96 17 0.177083333333333 0.1328125
REAC REAC:R-HSA-69206 G1/S Transition 6.88143400708894e-15 131 96 17 0.177083333333333 0.129770992366412
REAC REAC:R-HSA-2871837 FCERI mediated NF-kB activation 1.27965313705276e-14 136 96 17 0.177083333333333 0.125
REAC REAC:R-HSA-5621481 C-type lectin receptors (CLRs) 1.27965313705276e-14 136 96 17 0.177083333333333 0.125
REAC REAC:R-HSA-6807070 PTEN Regulation 1.60714562141691e-14 138 96 17 0.177083333333333 0.123188405797101
REAC REAC:R-HSA-446652 Interleukin-1 family signaling 1.60714562141691e-14 138 96 17 0.177083333333333 0.123188405797101
REAC REAC:R-HSA-3858494 Beta-catenin independent WNT signaling 2.91645024454103e-14 143 96 17 0.177083333333333 0.118881118881119
REAC REAC:R-HSA-162906 HIV Infection 3.15262966881768e-14 226 96 20 0.208333333333333 0.0884955752212389
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 4.49342184538257e-14 368 96 24 0.25 0.0652173913043478
REAC REAC:R-HSA-453279 Mitotic G1 phase and G1/S transition 5.06378198472673e-14 148 96 17 0.177083333333333 0.114864864864865
REAC REAC:R-HSA-5358351 Signaling by Hedgehog 5.56041556914402e-14 149 96 17 0.177083333333333 0.114093959731544
REAC REAC:R-HSA-69481 G2/M Checkpoints 5.56041556914402e-14 149 96 17 0.177083333333333 0.114093959731544
REAC REAC:R-HSA-69242 S Phase 2.24934985624637e-13 162 96 17 0.177083333333333 0.104938271604938
REAC REAC:R-HSA-983705 Signaling by the B Cell Receptor (BCR) 2.73437260488059e-13 164 96 17 0.177083333333333 0.103658536585366
REAC REAC:R-HSA-68882 Mitotic Anaphase 4.45286539968131e-13 228 96 19 0.197916666666667 0.0833333333333333
REAC REAC:R-HSA-2555396 Mitotic Metaphase and Anaphase 4.77467104609121e-13 229 96 19 0.197916666666667 0.0829694323144105
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 5.3294164506787e-13 171 96 17 0.177083333333333 0.0994152046783626
REAC REAC:R-HSA-5619115 Disorders of transmembrane transporters 6.40322944232418e-13 173 96 17 0.177083333333333 0.0982658959537572
REAC REAC:R-HSA-109581 Apoptosis 6.97927551301513e-13 174 96 17 0.177083333333333 0.0977011494252874
REAC REAC:R-HSA-5357801 Programmed Cell Death 9.17731716193778e-13 177 96 17 0.177083333333333 0.096045197740113
REAC REAC:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 1.44045632525487e-12 182 96 17 0.177083333333333 0.0934065934065934
REAC REAC:R-HSA-2467813 Separation of Sister Chromatids 2.43354972913879e-12 188 96 17 0.177083333333333 0.0904255319148936
REAC REAC:R-HSA-201681 TCF dependent signaling in response to WNT 4.72735761710035e-12 196 96 17 0.177083333333333 0.086734693877551
REAC REAC:R-HSA-69275 G2/M Transition 4.72735761710035e-12 196 96 17 0.177083333333333 0.086734693877551
REAC REAC:R-HSA-157118 Signaling by NOTCH 5.09085461241471e-12 197 96 17 0.177083333333333 0.0862944162436548
REAC REAC:R-HSA-453274 Mitotic G2-G2/M phases 5.48012223541858e-12 198 96 17 0.177083333333333 0.0858585858585859
REAC REAC:R-HSA-71403 Citric acid cycle (TCA cycle) 5.75458820594861e-12 22 79 8 0.10126582278481 0.363636363636364
REAC REAC:R-HSA-5689880 Ub-specific processing proteases 6.28807043718134e-12 200 96 17 0.177083333333333 0.085
REAC REAC:R-HSA-8878171 Transcriptional regulation by RUNX1 6.28807043718134e-12 200 96 17 0.177083333333333 0.085
REAC REAC:R-HSA-8951664 Neddylation 6.71380145014343e-12 233 96 18 0.1875 0.0772532188841202
REAC REAC:R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle 1.55807962733675e-11 54 79 10 0.126582278481013 0.185185185185185
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 2.29603756628134e-11 217 96 17 0.177083333333333 0.0783410138248848
REAC REAC:R-HSA-1257604 PIP3 activates AKT signaling 2.03877108279786e-10 249 96 17 0.177083333333333 0.0682730923694779
REAC REAC:R-HSA-195721 Signaling by WNT 2.84184810985104e-10 292 96 18 0.1875 0.0616438356164384
REAC REAC:R-HSA-5673001 RAF/MAP kinase cascade 5.0242938622562e-10 264 96 17 0.177083333333333 0.0643939393939394
REAC REAC:R-HSA-5684996 MAPK1/MAPK3 signaling 6.67863301573604e-10 269 96 17 0.177083333333333 0.0631970260223048
REAC REAC:R-HSA-69620 Cell Cycle Checkpoints 7.43476661089647e-10 271 96 17 0.177083333333333 0.0627306273062731
REAC REAC:R-HSA-156590 Glutathione conjugation 7.72569967152905e-10 34 54 7 0.12962962962963 0.205882352941176
REAC REAC:R-HSA-5688426 Deubiquitination 9.72075360544946e-10 276 96 17 0.177083333333333 0.0615942028985507
REAC REAC:R-HSA-9607240 FLT3 Signaling 1.07867893447998e-09 278 96 17 0.177083333333333 0.0611510791366906
REAC REAC:R-HSA-68886 M Phase 1.80604961761731e-09 371 96 19 0.197916666666667 0.0512129380053908
REAC REAC:R-HSA-9006925 Intracellular signaling by second messengers 1.93392575485921e-09 289 96 17 0.177083333333333 0.0588235294117647
REAC REAC:R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 5.04845799024203e-09 308 96 17 0.177083333333333 0.0551948051948052
REAC REAC:R-HSA-5683057 MAPK family signaling cascades 5.04845799024203e-09 308 96 17 0.177083333333333 0.0551948051948052
REAC REAC:R-HSA-449147 Signaling by Interleukins 3.66264314681957e-08 446 96 19 0.197916666666667 0.0426008968609865
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 7.73163536755136e-08 370 96 17 0.177083333333333 0.0459459459459459
REAC REAC:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 7.9841355594647e-08 371 96 17 0.177083333333333 0.045822102425876
REAC REAC:R-HSA-69278 Cell Cycle, Mitotic 3.32342802236238e-07 513 96 19 0.197916666666667 0.037037037037037
REAC REAC:R-HSA-156580 Phase II - Conjugation of compounds 2.1317590289797e-06 104 54 7 0.12962962962963 0.0673076923076923
REAC REAC:R-HSA-2262752 Cellular responses to stress 4.00751415107979e-06 546 96 18 0.1875 0.032967032967033
REAC REAC:R-HSA-422475 Axon guidance 4.30251028713418e-06 549 96 18 0.1875 0.0327868852459016
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 5.66521986565154e-06 560 96 18 0.1875 0.0321428571428571
REAC REAC:R-HSA-5663205 Infectious disease 6.56869711267524e-06 815 96 22 0.229166666666667 0.0269938650306748
REAC REAC:R-HSA-9675108 Nervous system development 7.91717571176485e-06 574 96 18 0.1875 0.0313588850174216
REAC REAC:R-HSA-1640170 Cell Cycle 9.42011119024095e-06 642 96 19 0.197916666666667 0.029595015576324
REAC REAC:R-HSA-211859 Biological oxidations 1.06123548465524e-05 215 63 9 0.142857142857143 0.0418604651162791
REAC REAC:R-HSA-8953854 Metabolism of RNA 1.55754812821771e-05 658 97 19 0.195876288659794 0.0288753799392097
REAC REAC:R-HSA-5423646 Aflatoxin activation and detoxification 2.65400092864901e-05 18 27 3 0.111111111111111 0.166666666666667
REAC REAC:R-HSA-72766 Translation 7.21292129674579e-05 292 89 11 0.123595505617978 0.0376712328767123
REAC REAC:R-HSA-5389840 Mitochondrial translation elongation 0.000195832922842241 87 89 6 0.0674157303370786 0.0689655172413793
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.00027838520857347 842 38 11 0.289473684210526 0.0130641330166271
REAC REAC:R-HSA-5368287 Mitochondrial translation 0.00028008152933189 93 89 6 0.0674157303370786 0.0645161290322581
REAC REAC:R-HSA-392499 Metabolism of proteins 0.000359598179731198 1961 96 33 0.34375 0.0168281489036206
REAC REAC:R-HSA-382551 Transport of small molecules 0.000496565300517472 718 96 17 0.177083333333333 0.0236768802228412
REAC REAC:R-HSA-168249 Innate Immune System 0.000541765227411807 1073 38 12 0.315789473684211 0.0111835973904939
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.000588072847617625 800 96 18 0.1875 0.0225
REAC REAC:R-HSA-70895 Branched-chain amino acid catabolism 0.000987264908060909 21 78 3 0.0384615384615385 0.142857142857143
REAC REAC:R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 0.00128638788889295 37 48 3 0.0625 0.0810810810810811
REAC REAC:R-HSA-5368286 Mitochondrial translation initiation 0.00168893709753887 87 89 5 0.0561797752808989 0.0574712643678161
REAC REAC:R-HSA-5419276 Mitochondrial translation termination 0.00168893709753887 87 89 5 0.0561797752808989 0.0574712643678161
REAC REAC:R-HSA-389661 Glyoxylate metabolism and glycine degradation 0.00225446507707 31 70 3 0.0428571428571429 0.0967741935483871
REAC REAC:R-HSA-1643685 Disease 0.00300305093573524 1509 42 14 0.333333333333333 0.00927766732935719
REAC REAC:R-HSA-1266738 Developmental Biology 0.00726708351906511 1069 38 10 0.263157894736842 0.00935453695042095
REAC REAC:R-HSA-212436 Generic Transcription Pathway 0.0138527775842295 1180 38 10 0.263157894736842 0.00847457627118644
REAC REAC:R-HSA-597592 Post-translational protein modification 0.0139237917758679 1377 38 11 0.289473684210526 0.00798838053740015
REAC REAC:R-HSA-8978868 Fatty acid metabolism 0.0160895867975131 173 50 4 0.08 0.023121387283237
REAC REAC:R-HSA-168256 Immune System 0.0232685169722214 2139 38 14 0.368421052631579 0.00654511453950444
REAC REAC:R-HSA-73857 RNA Polymerase II Transcription 0.0249157490507969 1301 38 10 0.263157894736842 0.00768639508070715
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.0420459150830412 474 38 5 0.131578947368421 0.0105485232067511
REAC REAC:R-HSA-74160 Gene expression (Transcription) 0.0429959403502049 1435 38 10 0.263157894736842 0.00696864111498258
REAC REAC:R-HSA-71387 Metabolism of carbohydrates 0.0442900744985829 285 43 4 0.0930232558139535 0.0140350877192982
TF TF:M10119 Factor: REX-1; motif: GGCMGCCATTTT 1.07892845368621e-06 1888 97 32 0.329896907216495 0.0169491525423729
TF TF:M12273 Factor: YY1; motif: GGCSGCCATTTTGN 7.83963325373485e-05 6229 97 57 0.587628865979381 0.00915074650826778
TF TF:M10849_1 Factor: Cdx-2; motif: NRTCGTAANNNN; match class: 1 7.83963325373485e-05 4497 59 33 0.559322033898305 0.00733822548365577
TF TF:M01744 Factor: REX1; motif: AANATGGCKGCN 7.8599038697789e-05 628 73 14 0.191780821917808 0.0222929936305732
TF TF:M02065 Factor: ER81; motif: RCCGGAARYN 7.8599038697789e-05 12550 94 83 0.882978723404255 0.00661354581673307
TF TF:M10849 Factor: Cdx-2; motif: NRTCGTAANNNN 9.3230961219779e-05 11163 60 53 0.883333333333333 0.00474782764489832
TF TF:M10104 Factor: YY1; motif: CAARATGGCGGC 9.3230961219779e-05 6071 97 55 0.56701030927835 0.00905946302091912
TF TF:M10785 Factor: hoxa9; motif: RTCGTWANNN 0.00011287494322039 5632 63 38 0.603174603174603 0.00674715909090909
TF TF:M12275 Factor: YY1; motif: NGCCGCCATYTTGN 0.000160712799092762 7043 98 60 0.612244897959184 0.00851909697572057
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.00021365760402714 8322 94 64 0.680851063829787 0.00769045902427301
TF TF:M07234 Factor: YY1; motif: CAARATGGCNGC 0.000231582002197666 6045 98 54 0.551020408163265 0.00893300248138958
TF TF:M01035 Factor: YY1; motif: NYNKCCATNTT 0.000231582002197666 5924 95 52 0.547368421052632 0.0087778528021607
TF TF:M08982 Factor: YY1; motif: NAANATGGCGNNN 0.000302132857353384 7125 97 59 0.608247422680412 0.00828070175438596
TF TF:M11424 Factor: Erm; motif: NNSCGGAWGYN 0.000352337932684269 8149 97 64 0.65979381443299 0.00785372438335992
TF TF:M11404 Factor: Fli-1; motif: NACCGGAARTN 0.000360032368402703 8743 94 65 0.691489361702128 0.00743451904380647
TF TF:M10785_1 Factor: hoxa9; motif: RTCGTWANNN; match class: 1 0.000360032368402703 1160 98 20 0.204081632653061 0.0172413793103448
TF TF:M03988 Factor: FLI1; motif: ACCGGAARTN 0.000360032368402703 8318 94 63 0.670212765957447 0.00757393604231787
TF TF:M01003 Factor: Helios; motif: NNTWGGGANNN 0.000379985401123051 3726 91 37 0.406593406593407 0.00993022007514761
TF TF:M11427 Factor: PEA3; motif: NACCGGAAGTN 0.000379985401123051 10585 94 73 0.776595744680851 0.00689655172413793
TF TF:M10799 Factor: HOXA10; motif: NRTCGTAAANN 0.000379985401123051 5646 62 36 0.580645161290323 0.00637619553666312
TF TF:M01752 Factor: ERG; motif: ACCGGAART 0.000420648056778381 9474 94 68 0.723404255319149 0.00717753852649356
TF TF:M04696 Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN 0.00051155583800534 7819 98 62 0.63265306122449 0.00792940273692288
TF TF:M07370 Factor: YY1; motif: NNNNAARATGGNNNN 0.00051155583800534 5811 95 50 0.526315789473684 0.0086043710204784
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.000547881292481036 11728 98 80 0.816326530612245 0.00682128240109141
TF TF:M03983 Factor: ETV5; motif: NCCGGAWGYN 0.000547881292481036 3129 96 34 0.354166666666667 0.0108660914030042
TF TF:M02059 Factor: ELK-1; motif: ACCGGAAGTN 0.000701931571645295 9423 94 67 0.712765957446808 0.00711026212458877
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.000701931571645295 6749 96 55 0.572916666666667 0.00814935546006816
TF TF:M09608 Factor: Erg; motif: NNACCGGAARTSN 0.000701931571645295 8152 92 60 0.652173913043478 0.00736015701668302
TF TF:M01078 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN 0.000723502868041755 7544 96 59 0.614583333333333 0.00782078472958643
TF TF:M12275_1 Factor: YY1; motif: NGCCGCCATYTTGN; match class: 1 0.000796406617873353 1600 93 22 0.236559139784946 0.01375
TF TF:M03862 Factor: YB-1; motif: NNNNCCAATNN 0.000828669988862604 9198 98 68 0.693877551020408 0.00739291150250054
TF TF:M00025 Factor: Elk-1; motif: NNNNCCGGAARTNN 0.000828669988862604 10262 98 73 0.744897959183674 0.00711362307542389
TF TF:M11400 Factor: Fli-1; motif: NACCGGAARTN 0.000843845867340014 9946 94 69 0.734042553191489 0.00693746229640056
TF TF:M10436 Factor: YY1; motif: CAANATGGCGGC 0.00091386288258999 8220 98 63 0.642857142857143 0.00766423357664234
TF TF:M11434 Factor: Elk-1; motif: NRSCGGAAGNN 0.00091386288258999 8219 98 63 0.642857142857143 0.00766516607859837
TF TF:M03975 Factor: ERG; motif: ACCGGAARTN 0.000966528036956395 10002 94 69 0.734042553191489 0.00689862027594481
TF TF:M03970 Factor: ELK1; motif: ACCGGAAGTN 0.000966528036956395 4782 92 42 0.456521739130435 0.00878293601003764
TF TF:M12310 Factor: ZNF597; motif: NGCCGCCATTTTGN 0.000966528036956395 437 75 10 0.133333333333333 0.022883295194508
TF TF:M11419 Factor: ER81; motif: NNCCGGAWGYN 0.000966528036956395 5699 92 47 0.510869565217391 0.00824706088787507
TF TF:M08206_1 Factor: E2F-3:Prrxl1; motif: SGCGCTAATTNN; match class: 1 0.00100578342768388 5052 29 19 0.655172413793103 0.00376088677751386
TF TF:M09935 Factor: GABP-alpha; motif: NNNRCCGGAAGTGN 0.00100578342768388 4420 96 41 0.427083333333333 0.00927601809954751
TF TF:M03977 Factor: ETS1; motif: ACCGGAARYN 0.00100578342768388 10512 94 71 0.75531914893617 0.00675418569254186
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.00100578342768388 8319 94 61 0.648936170212766 0.00733261209279962
TF TF:M01163 Factor: Elk-1; motif: AACCGGAAGTR 0.00100578342768388 5260 96 46 0.479166666666667 0.00874524714828897
TF TF:M03925 Factor: YY2; motif: NCCGCCATNTY 0.00100578342768388 4641 98 43 0.438775510204082 0.00926524455936221
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.00106965395320484 10765 94 72 0.765957446808511 0.00668834184858337
TF TF:M07061 Factor: POU4F3; motif: CTAATYW 0.00150176588589075 7215 47 32 0.680851063829787 0.00443520443520443
TF TF:M11425 Factor: PEA3; motif: NACCGGAAGTN 0.00164384661256198 7428 96 57 0.59375 0.00767366720516963
TF TF:M10783 Factor: hoxa9; motif: RTCGTWAANN 0.00175383911700323 1897 98 24 0.244897959183673 0.0126515550869794
TF TF:M01863 Factor: ATF-3; motif: RTKRCGTCANN 0.00175383911700323 1885 46 15 0.326086956521739 0.00795755968169761
TF TF:M11392 Factor: Erg; motif: NACCGGAARYN 0.00175806463105414 8690 94 62 0.659574468085106 0.00713463751438435
TF TF:M09904 Factor: Elk-1; motif: RCCGGAAGTGN 0.00175806463105414 8164 93 59 0.634408602150538 0.00722684958353748
TF TF:M03791 Factor: GABPalpha_GABPbeta; motif: CTTCCKGY 0.00175806463105414 2969 91 30 0.32967032967033 0.0101044122600202
TF TF:M00793 Factor: YY1; motif: GCCATNTTN 0.00183462792689805 5186 97 45 0.463917525773196 0.00867720786733513
TF TF:M11433 Factor: Elk-1; motif: NRCCGGAAGTN 0.00184415657430215 7679 96 58 0.604166666666667 0.00755306680557364
TF TF:M02063 Factor: c-ets-1; motif: ACCGGAWGTN 0.00200187363372047 7600 93 56 0.602150537634409 0.00736842105263158
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.00200187363372047 14997 82 77 0.939024390243902 0.00513436020537441
TF TF:M11005 Factor: LHX4; motif: NNCRTTAN 0.00212442876537081 10614 98 73 0.744897959183674 0.00687770868664029
TF TF:M11396_1 Factor: Erg; motif: NACCGGAARTN; match class: 1 0.0022794478734291 4963 93 42 0.451612903225806 0.00846262341325811
TF TF:M02066 Factor: PEA3; motif: RCCGGAAGYN 0.00235089768254891 7045 93 53 0.56989247311828 0.00752306600425834
TF TF:M02044 Factor: YY1; motif: GCCGCCATTTTG 0.00250791296039644 6102 76 41 0.539473684210526 0.00671910848901999
TF TF:M00025_1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 0.00250791296039644 4639 93 40 0.43010752688172 0.00862254796292304
TF TF:M08213 Factor: Elk-1:TBR2; motif: TNRCACCGGAAGN 0.00250791296039644 6273 98 51 0.520408163265306 0.00813008130081301
TF TF:M00793_1 Factor: YY1; motif: GCCATNTTN; match class: 1 0.00257830269219966 819 59 11 0.186440677966102 0.0134310134310134
TF TF:M10948 Factor: rax; motif: NNCRTTAN 0.00257830269219966 11816 98 78 0.795918367346939 0.00660121868652674
TF TF:M11420 Factor: ER81; motif: NACCGGAAGTN 0.00288680383052942 3210 96 32 0.333333333333333 0.00996884735202492
TF TF:M02064 Factor: c-ets-2; motif: ACCGGAWRTN 0.00295262243373962 10939 92 70 0.760869565217391 0.00639912240607002
TF TF:M09900 Factor: Elf-1; motif: NNANCCGGAAGTGS 0.00295262243373962 5219 93 43 0.462365591397849 0.00823912626940027
TF TF:M02263 Factor: NFE2L2; motif: RTGACWCAGCA 0.0034079000622975 3025 72 25 0.347222222222222 0.00826446280991736
TF TF:M02068 Factor: etv3; motif: ACCGGAAGYN 0.0034079000622975 3443 91 32 0.351648351648352 0.00929422015683997
TF TF:M01167 Factor: SAP-1a; motif: NACCGGAAGTV 0.00405660518867616 1948 96 23 0.239583333333333 0.0118069815195072
TF TF:M02071_1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 0.00414467547121459 4465 92 38 0.41304347826087 0.00851063829787234
TF TF:M07370_1 Factor: YY1; motif: NNNNAARATGGNNNN; match class: 1 0.0044574849178439 1076 95 16 0.168421052631579 0.0148698884758364
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 0.00466653927512295 336 40 6 0.15 0.0178571428571429
TF TF:M08231 Factor: Elk-1:T-bet; motif: TCACACCGGAAGNN 0.00471315785703435 6635 98 52 0.530612244897959 0.00783722682743029
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 0.00471315785703435 1617 40 12 0.3 0.00742115027829314
TF TF:M11428 Factor: PEA3; motif: NACCGGAAGTN 0.0047545823322957 7186 96 54 0.5625 0.00751461174505984
TF TF:M07061_1 Factor: POU4F3; motif: CTAATYW; match class: 1 0.00475956644070272 1890 35 12 0.342857142857143 0.00634920634920635
TF TF:M04714 Factor: Elf-1; motif: ACTTCCGGG 0.00508593885920305 7798 96 57 0.59375 0.00730956655552706
TF TF:M03982 Factor: ETV4; motif: ACCGGAAGTN 0.00508593885920305 6826 96 52 0.541666666666667 0.00761793143861705
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 0.00536061774995586 1651 40 12 0.3 0.00726832222895215
TF TF:M02061 Factor: ERF; motif: ACCGGAARYN 0.0053742292813842 2579 96 27 0.28125 0.0104691740984878
TF TF:M11422_1 Factor: Erm; motif: NRCMGGAAGTN; match class: 1 0.00552720893037685 934 31 8 0.258064516129032 0.00856531049250535
TF TF:M10956 Factor: isx; motif: NTCRTTAA 0.00557720798553437 9441 98 66 0.673469387755102 0.00699078487448364
TF TF:M11430 Factor: PEA3; motif: NACCGGAAGTN 0.00591498140459934 10865 94 70 0.74468085106383 0.00644270593649333
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.00596007696761013 14593 98 88 0.897959183673469 0.00603028849448366
TF TF:M11414 Factor: GABP-alpha; motif: NACCGGAAGTN 0.00596007696761013 2907 96 29 0.302083333333333 0.00997592019263846
TF TF:M09905 Factor: SAP-1; motif: NNCCGGAAGTGN 0.00596007696761013 8273 94 58 0.617021276595745 0.00701075788710262
TF TF:M08982_1 Factor: YY1; motif: NAANATGGCGNNN; match class: 1 0.00596007696761013 1662 66 16 0.242424242424242 0.00962695547533093
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 0.00596007696761013 3595 40 18 0.45 0.00500695410292072
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.00596007696761013 14873 98 89 0.908163265306122 0.00598399784845021
TF TF:M01830 Factor: MAX; motif: CNNGMCACGTGN 0.00596007696761013 104 84 5 0.0595238095238095 0.0480769230769231
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.00596007696761013 10116 98 69 0.704081632653061 0.0068208778173191
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 0.00596007696761013 535 40 7 0.175 0.0130841121495327
TF TF:M01035_1 Factor: YY1; motif: NYNKCCATNTT; match class: 1 0.00611576715868442 1112 59 12 0.203389830508475 0.0107913669064748
TF TF:M04287 Factor: BARHL2; motif: NNTAAAYGNN 0.00640041350298016 4416 89 36 0.404494382022472 0.00815217391304348
TF TF:M11415 Factor: GABP-alpha; motif: NRCCGGAAGTN 0.00678253788460291 3257 96 31 0.322916666666667 0.00951796131409272
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 0.00708047185321546 622 36 7 0.194444444444444 0.0112540192926045
TF TF:M02067 Factor: ER71; motif: ACCGGAARYN 0.00708047185321546 5930 92 45 0.489130434782609 0.0075885328836425
TF TF:M08313 Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR 0.00708047185321546 15419 57 55 0.964912280701754 0.00356702769310591
TF TF:M10104_1 Factor: YY1; motif: CAARATGGCGGC; match class: 1 0.00716364426254005 1138 59 12 0.203389830508475 0.0105448154657293
TF TF:M11432 Factor: Elk-1; motif: NACMGGAAGTN 0.00736346048045349 6140 92 46 0.5 0.00749185667752443
TF TF:M00069 Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW 0.00743627031139649 8347 98 60 0.612244897959184 0.0071882113334132
TF TF:M07047_1 Factor: Lhx2; motif: WATTAN; match class: 1 0.00774155750017105 4624 28 16 0.571428571428571 0.00346020761245675
TF TF:M09605 Factor: Elf-1; motif: NAANCMGGAAGTGN 0.00782686613765066 5778 92 44 0.478260869565217 0.00761509172724126
TF TF:M10436_1 Factor: YY1; motif: CAANATGGCGGC; match class: 1 0.00821566607294033 2285 72 20 0.277777777777778 0.0087527352297593
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.0087747491376033 11116 98 73 0.744897959183674 0.00656711047139259
TF TF:M07234_1 Factor: YY1; motif: CAARATGGCNGC; match class: 1 0.00903308388541692 1177 59 12 0.203389830508475 0.0101954120645709
TF TF:M01230_1 Factor: ZNF333; motif: ATAAT; match class: 1 0.00903308388541692 11582 95 73 0.768421052631579 0.00630288378518391
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 0.00903308388541692 2396 40 14 0.35 0.00584307178631052
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.00904376211983357 16228 90 86 0.955555555555556 0.00529948237614
TF TF:M01258 Factor: GABP; motif: CACTTCCGGNNN 0.00907670024448439 2838 92 27 0.293478260869565 0.00951374207188161
TF TF:M08418_1 Factor: TEF-3:Elk-1; motif: RMATWCCGGAWGT; match class: 1 0.00907670024448439 5247 98 43 0.438775510204082 0.00819515913855537
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 0.00912656245496486 1267 40 10 0.25 0.00789265982636148
TF TF:M10727_1 Factor: HOXB8; motif: RTCRTTAN; match class: 1 0.00918479692515298 1379 91 17 0.186813186813187 0.0123277737490935
TF TF:M11451 Factor: Elf-1; motif: NANCCGGAAGTN 0.0101339963930194 6886 96 51 0.53125 0.00740633168748185
TF TF:M08526 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN 0.0102921340744814 16867 98 95 0.969387755102041 0.0056322997569218
TF TF:M10815 Factor: HOXC11; motif: NRTCGTAAANN 0.0112525158868553 1139 91 15 0.164835164835165 0.0131694468832309
TF TF:M00178 Factor: CREB; motif: NSTGACGTMANN 0.0113464809994198 5255 96 42 0.4375 0.00799238820171265
TF TF:M11447 Factor: Elf-1; motif: NAMCCGGAAGTN 0.0114035699964288 7703 96 55 0.572916666666667 0.00714007529533948
TF TF:M04018 Factor: IRF7; motif: NCGAAARYGAAANT 0.0114035699964288 619 40 7 0.175 0.0113085621970921
TF TF:M09607 Factor: SAP-1; motif: ACCGGAAGTNN 0.0115627095756565 4727 93 38 0.408602150537634 0.00803892532261477
TF TF:M11529 Factor: E2F-2; motif: GCGCGCGCNCS 0.0119019133775582 16263 98 93 0.948979591836735 0.00571850212137982
TF TF:M09901 Factor: nerf; motif: NNNCCGGAAGTGN 0.0121281169512027 5352 92 41 0.445652173913043 0.00766068759342302
TF TF:M04698 Factor: GABP-alpha; motif: CACTTCCGG 0.0121977662230384 3196 93 29 0.311827956989247 0.0090738423028786
TF TF:M03977_1 Factor: ETS1; motif: ACCGGAARYN; match class: 1 0.0126082623781027 4677 88 36 0.409090909090909 0.00769724182168056
TF TF:M10625 Factor: Nkx3-2; motif: NTCGTTAN 0.0126082623781027 6062 98 47 0.479591836734694 0.00775321676014517
TF TF:M02104 Factor: NF-E2; motif: CATGACTCAGCANNCN 0.0126334839351098 1146 38 9 0.236842105263158 0.00785340314136126
TF TF:M01230 Factor: ZNF333; motif: ATAAT 0.0128367959691115 15485 78 73 0.935897435897436 0.0047142395866968
TF TF:M10591 Factor: BSX; motif: NNCGTTAN 0.0128367959691115 7760 98 56 0.571428571428571 0.00721649484536083
TF TF:M11406 Factor: Pet-1; motif: NACCGGAAGTN 0.0131430132302234 1301 91 16 0.175824175824176 0.0122982321291314
TF TF:M11705_1 Factor: MRG2; motif: TGACASSTGTCA; match class: 1 0.0131430132302234 254 25 4 0.16 0.015748031496063
TF TF:M03544 Factor: CREB1; motif: NNNNACGTCANN 0.013563243693103 4101 96 35 0.364583333333333 0.00853450377956596
TF TF:M11320_1 Factor: C/EBPdelta; motif: NRTTGCGYAAYN; match class: 1 0.0137918520134964 2586 4 4 1 0.00154679040989946
TF TF:M04696_1 Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN; match class: 1 0.0137918520134964 1973 62 16 0.258064516129032 0.00810947795235682
TF TF:M11422 Factor: Erm; motif: NRCMGGAAGTN 0.0139676914013225 4669 92 37 0.402173913043478 0.00792460912400942
TF TF:M02022 Factor: MafK; motif: TGASTCAGCDN 0.0141570132401489 311 38 5 0.131578947368421 0.0160771704180064
TF TF:M11705 Factor: MRG2; motif: TGACASSTGTCA 0.0142124472002415 298 61 6 0.0983606557377049 0.0201342281879195
TF TF:M00916 Factor: CREB; motif: NNTKACGTCANNNS 0.0142436487393025 5889 96 45 0.46875 0.0076413652572593
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.0142436487393025 14473 89 79 0.887640449438202 0.00545843985352035
TF TF:M03967 Factor: ELF3; motif: WACCCGGAAGTAN 0.0145291196366191 7610 96 54 0.5625 0.00709592641261498
TF TF:M08979_1 Factor: VDR; motif: NRRGTTCA; match class: 1 0.0145291196366191 709 27 6 0.222222222222222 0.00846262341325811
TF TF:M10996_1 Factor: LMX1A; motif: YTAATTAN; match class: 1 0.0145837412719564 89 73 4 0.0547945205479452 0.0449438202247191
TF TF:M03981 Factor: ETV3; motif: ACCGGAAGTN 0.0146452304250136 2327 92 23 0.25 0.00988397077782553
TF TF:M10783_1 Factor: hoxa9; motif: RTCGTWAANN; match class: 1 0.0147218631558579 130 91 5 0.0549450549450549 0.0384615384615385
TF TF:M08626 Factor: TEF-3:C/EBPbeta; motif: RTTGCGYAAYNNNNNGGAATGY 0.0155002284881266 7003 92 49 0.532608695652174 0.0069970012851635
TF TF:M03987 Factor: FEV; motif: ACCGGAAGTN 0.0155062950265421 1318 92 16 0.173913043478261 0.0121396054628225
TF TF:M08206 Factor: E2F-3:Prrxl1; motif: SGCGCTAATTNN 0.0155062950265421 11802 98 75 0.76530612244898 0.00635485510930351
TF TF:M02053 Factor: ELF1; motif: NCCGGAARTN 0.0160175686803853 6033 92 44 0.478260869565217 0.00729322061992375
TF TF:M01742 Factor: Zfp206; motif: TGCGCAKGCGC 0.0160715527501175 274 69 6 0.0869565217391304 0.0218978102189781
TF TF:M07419 Factor: FOXP3; motif: NNNVAAACANWD 0.0160715527501175 6311 91 45 0.494505494505495 0.00713040722547932
TF TF:M11530_1 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN; match class: 1 0.0160715527501175 13449 98 82 0.836734693877551 0.0060971075916425
TF TF:M02062 Factor: Erg; motif: ACCGGAAGTN 0.0160715527501175 8056 98 57 0.581632653061224 0.00707547169811321
TF TF:M11432_1 Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 0.0163915644783705 1525 31 9 0.290322580645161 0.0059016393442623
TF TF:M03972 Factor: ELK3; motif: ACCGGAAGTN 0.0163915644783705 1211 91 15 0.164835164835165 0.0123864574731627
TF TF:M12273_1 Factor: YY1; motif: GGCSGCCATTTTGN; match class: 1 0.0165767207840877 1261 61 12 0.19672131147541 0.00951625693893735
TF TF:M08402 Factor: POU2F1:PEA3; motif: ACCGGATATGCAN 0.0168992668704208 8519 67 43 0.641791044776119 0.00504754079117267
TF TF:M11704 Factor: MRG2; motif: TGACASSTGTCA 0.0174836912856807 451 79 8 0.10126582278481 0.0177383592017738
TF TF:M11384_1 Factor: ESE-1; motif: ACCCGGAAGTRNNNNNNNWWWWW; match class: 1 0.0180397409376427 408 67 7 0.104477611940299 0.017156862745098
TF TF:M11033_1 Factor: Six-2; motif: NCGTATCRYN; match class: 1 0.0183351775548172 2382 92 23 0.25 0.00965575146935348
TF TF:M07114 Factor: c-MAF:NF-E2p45; motif: ATGACTCAGCANWTN 0.0187389493585192 745 38 7 0.184210526315789 0.00939597315436242
TF TF:M09593 Factor: Bach1; motif: TGCTGAGTCANNS 0.0197402374915588 536 38 6 0.157894736842105 0.0111940298507463
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 0.0197402374915588 2761 39 14 0.358974358974359 0.00507062658457081
TF TF:M10880 Factor: Alx-4; motif: NNCRTTAN 0.0203431388090629 8535 98 59 0.602040816326531 0.00691271236086702
TF TF:M00981 Factor: CREB,; motif: NTGACGTNA 0.020515821108874 8345 96 57 0.59375 0.00683043738765728
TF TF:M03916 Factor: PRDM1; motif: NRAAAGTGAAAGTNN 0.020515821108874 948 31 7 0.225806451612903 0.00738396624472574
TF TF:M04626 Factor: Prop-1; motif: WNCTWATT 0.020515821108874 764 74 10 0.135135135135135 0.0130890052356021
TF TF:M12082 Factor: ZNF76; motif: NNTWCCCAYAATGCANYGCGN 0.020515821108874 146 51 4 0.0784313725490196 0.0273972602739726
TF TF:M07047 Factor: Lhx2; motif: WATTAN 0.0210516266657157 10826 28 24 0.857142857142857 0.00221688527618696
TF TF:M02063_1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 0.0210516266657157 2396 76 20 0.263157894736842 0.00834724540901502
TF TF:M07610 Factor: Nrf2; motif: NTGCTGAGTCANN 0.0210516266657157 1012 38 8 0.210526315789474 0.00790513833992095
TF TF:M00183_1 Factor: c-Myb; motif: NNNAACTGNC; match class: 1 0.0211758876821971 228 89 6 0.0674157303370786 0.0263157894736842
TF TF:M11449 Factor: Elf-1; motif: NANCCGGAAGTN 0.0214744706021272 4305 95 35 0.368421052631579 0.00813008130081301
TF TF:M11033 Factor: Six-2; motif: NCGTATCRYN 0.0215985055261106 8598 90 55 0.611111111111111 0.00639683647359851
TF TF:M00747 Factor: IRF-1; motif: TTCACTT 0.0216644466776652 5208 12 9 0.75 0.00172811059907834
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.0218201822238677 16194 98 92 0.938775510204082 0.00568111646288749
TF TF:M11452 Factor: Elf-1; motif: NANGCGGAAGTR 0.0218201822238677 6276 93 45 0.483870967741935 0.00717017208413002
TF TF:M09600 Factor: CREB1; motif: TKACGTCAYNN 0.0218201822238677 5324 96 41 0.427083333333333 0.00770097670924117
TF TF:M07248 Factor: CREB1; motif: NNNNTGACGTNANNN 0.0218201822238677 4266 96 35 0.364583333333333 0.00820440693858415
TF TF:M08759_1 Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 0.0219605142920106 2915 42 15 0.357142857142857 0.00514579759862779
TF TF:M01306_1 Factor: ZABC1; motif: ATTCCNAC; match class: 1 0.0224778200577327 2690 20 9 0.45 0.0033457249070632
TF TF:M10007 Factor: TTF-1; motif: NTKGAGTGSN 0.0232176333672219 4630 83 33 0.397590361445783 0.00712742980561555
TF TF:M04691 Factor: Kaiso; motif: TCTCGCGAG 0.0232176333672219 15113 98 88 0.897959183673469 0.00582280156156951
TF TF:M07312 Factor: ATF-2; motif: NNTGACGTCAN 0.0232176333672219 3483 95 30 0.315789473684211 0.00861326442721792
TF TF:M12352 Factor: ZBTB44; motif: MACWGCAGS 0.023441284706406 6614 54 30 0.555555555555556 0.00453583308134261
TF TF:M08223_1 Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 0.023441284706406 5853 86 40 0.465116279069767 0.00683410216982744
TF TF:M04015 Factor: IRF-4; motif: NCGAAACCGAAACYA 0.023441284706406 2038 47 13 0.276595744680851 0.00637880274779195
TF TF:M10170 Factor: ZNF85; motif: ANAGAARWCTGMWGKAATCT 0.023441284706406 181 77 5 0.0649350649350649 0.0276243093922652
TF TF:M08451 Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA 0.023441284706406 8421 96 57 0.59375 0.00676879230495191
TF TF:M08458 Factor: Erm:C/EBPdelta; motif: RSCGGAWRTTGCGYAAY 0.023441284706406 9714 92 61 0.66304347826087 0.00627959645871937
TF TF:M10098 Factor: DP-1; motif: NRNNGGCGGGAANN 0.023441284706406 7015 7 7 1 0.000997861724875267
TF TF:M08339 Factor: HOXB2:Elf-1; motif: SCGGAAGTMRTTA 0.023441284706406 1690 92 18 0.195652173913043 0.0106508875739645
TF TF:M04020 Factor: IRF8; motif: NCGAAACCGAAACT 0.0235023697863707 992 40 8 0.2 0.00806451612903226
TF TF:M07207 Factor: EBF1; motif: NTCCCCWGGGA 0.0235023697863707 483 8 3 0.375 0.0062111801242236
TF TF:M11407 Factor: Pet-1; motif: NACCGGAAGTN 0.0235023697863707 772 76 10 0.131578947368421 0.0129533678756477
TF TF:M11715 Factor: TGIF2; motif: TGACAGCTGTCA 0.0235023697863707 638 61 8 0.131147540983607 0.0125391849529781
TF TF:M09962_1 Factor: ITF-2; motif: NGCAGSTGKS; match class: 1 0.0235023697863707 768 51 8 0.156862745098039 0.0104166666666667
TF TF:M08959_1 Factor: PAX-7; motif: NASCGTRACKAAT; match class: 1 0.0235023697863707 3856 10 7 0.7 0.00181535269709544
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 0.0238380969649444 562 39 6 0.153846153846154 0.0106761565836299
TF TF:M01861 Factor: ATF-1; motif: TNACGTCAN 0.0238380969649444 6294 96 46 0.479166666666667 0.0073085478233238
TF TF:M11384 Factor: ESE-1; motif: ACCCGGAAGTRNNNNNNNWWWWW 0.0239286444857267 3272 24 11 0.458333333333333 0.00336185819070905
TF TF:M04802_1 Factor: c-Fos; motif: ACTCACCA; match class: 1 0.0239286444857267 1481 56 12 0.214285714285714 0.00810263335584065
TF TF:M11375 Factor: Spi-B; motif: NAWGCGGAAGTN 0.0240970696484413 2608 52 16 0.307692307692308 0.00613496932515337
TF TF:M10558 Factor: Prox-1; motif: NAAGGCGTCNTN 0.0249086504728726 996 82 12 0.146341463414634 0.0120481927710843
TF TF:M02055 Factor: ESE-1; motif: NSMGGAARTN 0.025228109898998 7559 95 52 0.547368421052632 0.0068792168276227
TF TF:M01214 Factor: ESE-1; motif: NSMGGAARTN 0.025228109898998 7559 95 52 0.547368421052632 0.0068792168276227
TF TF:M00039 Factor: CREB; motif: TGACGTMA 0.0259861980002624 5222 96 40 0.416666666666667 0.00765990042129452
TF TF:M01229 Factor: GTF2IRD1-isoform2; motif: GGGATTRNR 0.0263780213321725 15179 98 88 0.897959183673469 0.00579748336517557
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 0.0265341884250312 4690 40 19 0.475 0.00405117270788913
TF TF:M11381 Factor: ESE-1; motif: SATKGCGGATGCN 0.026575254533271 15720 98 90 0.918367346938776 0.00572519083969466
TF TF:M09871 Factor: bach2; motif: TGCTGAGTCAN 0.0270640001586216 395 38 5 0.131578947368421 0.0126582278481013
TF TF:M09887 Factor: CREB1; motif: NRRTGACGTMA 0.0270640001586216 5419 96 41 0.427083333333333 0.0075659715814726
TF TF:M07464_1 Factor: Prep-1; motif: GRBTGANAGATN; match class: 1 0.0271232391413614 607 7 3 0.428571428571429 0.00494233937397035
TF TF:M03925_1 Factor: YY2; motif: NCCGCCATNTY; match class: 1 0.0272062746177439 765 79 10 0.126582278481013 0.0130718954248366
TF TF:M00485 Factor: Nkx2-2; motif: TTAAGTRSTT 0.0272222053926064 2603 94 24 0.25531914893617 0.0092201306185171
TF TF:M08917 Factor: GABP-ALPHA; motif: RCCGGAARTNN 0.0272222053926064 2702 96 25 0.260416666666667 0.00925240562546262
TF TF:M10557 Factor: Prox-1; motif: NAAGRCGTCTTN 0.0276293640179606 1391 45 10 0.222222222222222 0.00718907260963336
TF TF:M09818 Factor: PRDM1; motif: TCACTTTCWC 0.0276293640179606 1087 22 6 0.272727272727273 0.00551977920883165
TF TF:M09913 Factor: ER81; motif: NNCCGGAAGYG 0.0281775614325451 2871 91 25 0.274725274725275 0.00870776732845698
TF TF:M00981_1 Factor: CREB,; motif: NTGACGTNA; match class: 1 0.028381196237563 2904 95 26 0.273684210526316 0.00895316804407714
TF TF:M10593 Factor: Dlx-6; motif: NTCRTTAN 0.0286221610534771 7158 98 51 0.520408163265306 0.00712489522212909
TF TF:M11436 Factor: SAP-1; motif: NRNCGGAWRYN 0.0288031238172881 1431 76 14 0.184210526315789 0.00978336827393431
TF TF:M11389 Factor: elf5; motif: GAMCCGGAAGTN 0.0291077384988154 1308 65 12 0.184615384615385 0.00917431192660551
TF TF:M02069 Factor: Erm; motif: ACCGGAAGTN 0.0291077384988154 6892 92 47 0.510869565217391 0.00681950087057458
TF TF:M11381_1 Factor: ESE-1; motif: SATKGCGGATGCN; match class: 1 0.0293710316146721 9745 98 64 0.653061224489796 0.00656747049769112
TF TF:M10742 Factor: Hox-D3; motif: GTCRTTAR 0.0293710316146721 530 77 8 0.103896103896104 0.0150943396226415
TF TF:M10709 Factor: HOXD4; motif: NYMATKAN 0.0293710316146721 530 77 8 0.103896103896104 0.0150943396226415
TF TF:M02219_1 Factor: NR3C1; motif: RRGAACATWMYGTYCTRN; match class: 1 0.0306155029305548 1458 12 5 0.416666666666667 0.00342935528120713
TF TF:M01589 Factor: ERR2; motif: YCAAGGTCANNN 0.0313626309331154 254 91 6 0.0659340659340659 0.0236220472440945
TF TF:M11715_1 Factor: TGIF2; motif: TGACAGCTGTCA; match class: 1 0.0317886910078878 527 61 7 0.114754098360656 0.0132827324478178
TF TF:M02066_1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 0.0326094825103104 2283 96 22 0.229166666666667 0.00963644327639071
TF TF:M10795 Factor: HOXA10; motif: NGTCGTAAAAN 0.0326094825103104 6913 60 33 0.55 0.00477361492839578
TF TF:M11389_1 Factor: elf5; motif: GAMCCGGAAGTN; match class: 1 0.0326094825103104 99 42 3 0.0714285714285714 0.0303030303030303
TF TF:M12243 Factor: Blimp-1; motif: NAGKGAAAGTGN 0.0326094825103104 1987 18 7 0.388888888888889 0.00352289884247609
TF TF:M11714_1 Factor: TGIF2; motif: TGACANNTGTCA; match class: 1 0.0332146868645445 533 61 7 0.114754098360656 0.0131332082551595
TF TF:M08313_1 Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 0.0335867924770393 9721 97 63 0.649484536082474 0.00648081473099475
TF TF:M07386 Factor: Lmx1; motif: RDNTAATT 0.0335867924770393 6123 47 25 0.531914893617021 0.00408296586640536
TF TF:M11427_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0335867924770393 4606 96 36 0.375 0.00781589231437256
TF TF:M01967 Factor: Pbx; motif: NKTGATTGACRKSN 0.0335867924770393 5077 94 38 0.404255319148936 0.00748473507977152
TF TF:M00179 Factor: ATF2; motif: VGTGACGTMACN 0.0335867924770393 6065 96 44 0.458333333333333 0.00725474031327288
TF TF:M02056 Factor: ELF4; motif: NCCGGAARTN 0.0335867924770393 5332 93 39 0.419354838709677 0.00731432858214554
TF TF:M03835 Factor: Nrf2; motif: ACNRTGACTCAGCANWA 0.0335867924770393 1562 49 11 0.224489795918367 0.00704225352112676
TF TF:M10727 Factor: HOXB8; motif: RTCRTTAN 0.0335867924770393 6289 98 46 0.469387755102041 0.00731435840356177
TF TF:M04458_1 Factor: ESRRA; motif: CAAGGTCANNYSAAGGTCA; match class: 1 0.0335867924770393 4477 85 32 0.376470588235294 0.00714764351127987
TF TF:M00017 Factor: ATF; motif: CNSTGACGTNNNYC 0.0335867924770393 7226 98 51 0.520408163265306 0.00705784666482148
TF TF:M10578_1 Factor: Barhl-1; motif: NTAAACGN; match class: 1 0.0336537742491779 1391 98 16 0.163265306122449 0.0115025161754134
TF TF:M03563 Factor: RelA-p65; motif: GGGANTTTCCNN 0.0337999673154276 4643 63 26 0.412698412698413 0.0055998276976093
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.0340335649309312 4841 92 36 0.391304347826087 0.00743648006610205
TF TF:M08412 Factor: rfx3:SREBP-2; motif: ATGGYAACRTCACGTGAY 0.0340436088919408 10607 63 46 0.73015873015873 0.00433675874422551
TF TF:M11223 Factor: CREB1; motif: NRTGACGTCANN 0.0351292084306857 2810 95 25 0.263157894736842 0.00889679715302491
TF TF:M08220_1 Factor: Elk-1:HOXA3; motif: ACCGGWAATKRNNTNWCNNATTAN; match class: 1 0.0351292084306857 5350 93 39 0.419354838709677 0.00728971962616822
TF TF:M02058 Factor: SAP1A; motif: NCCGGAARYN 0.0351674076262914 842 76 10 0.131578947368421 0.0118764845605701
TF TF:M11442 Factor: Net; motif: NACCGGAAGTN 0.0357549446853828 2012 96 20 0.208333333333333 0.0099403578528827
TF TF:M02070 Factor: TEL1; motif: CNCGGAANNN 0.0357549446853828 10837 92 65 0.706521739130435 0.00599796991787395
TF TF:M06605 Factor: ZNF681; motif: SGGGGTAAAGM 0.0357549446853828 48 92 3 0.0326086956521739 0.0625
TF TF:M08779 Factor: PXR; motif: AGTTCANNSAGTTC 0.035863240635064 3913 52 20 0.384615384615385 0.00511116790186558
TF TF:M11437 Factor: SAP-1; motif: NRCCGGAWGYN 0.0359799339235767 2788 96 25 0.260416666666667 0.00896700143472023
TF TF:M07314 Factor: Blimp-1; motif: RGRAAGNGAAAG 0.0360963607009309 1460 31 8 0.258064516129032 0.00547945205479452
TF TF:M11882 Factor: pax-6; motif: NYACGCNYSANYGMNCN 0.0360963607009309 15490 89 81 0.910112359550562 0.005229180116204
TF TF:M11438 Factor: SAP-1; motif: NTCGTAAATGCN 0.0376102968303329 5901 67 32 0.477611940298507 0.00542280969327233
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 0.0377672561179126 14575 98 85 0.86734693877551 0.00583190394511149
TF TF:M08341 Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN 0.0378164666015391 6145 93 43 0.462365591397849 0.00699755899104963
TF TF:M03990 Factor: GABPA; motif: ACCGGAAGTN 0.0378164666015391 5258 92 38 0.41304347826087 0.00722708254089007
TF TF:M11418 Factor: ER81; motif: NRCMGGAWGNN 0.0382013410435969 3978 92 31 0.33695652173913 0.0077928607340372
TF TF:M09784 Factor: RELB; motif: NNATTCCCCNN 0.0382013410435969 5356 32 17 0.53125 0.00317401045556385
TF TF:M02073 Factor: Fli-1; motif: ACCGGAAGYN 0.0382013410435969 5839 92 41 0.445652173913043 0.00702175029970885
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 0.0382013410435969 272 37 4 0.108108108108108 0.0147058823529412
TF TF:M07057 Factor: Pitx3; motif: GATTANA 0.0383960785867092 2284 86 20 0.232558139534884 0.00875656742556918
TF TF:M09904_1 Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 0.0385036586831333 2743 93 24 0.258064516129032 0.00874954429456799
TF TF:M00148_1 Factor: SRY; motif: AAACWAM; match class: 1 0.0386743150246667 4397 91 33 0.362637362637363 0.00750511712531271
TF TF:M10683_1 Factor: HOXB7; motif: GTCRTTAN; match class: 1 0.0387469762303171 110 91 4 0.043956043956044 0.0363636363636364
TF TF:M09905_1 Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 0.038783078922033 2989 86 24 0.27906976744186 0.00802944128471061
TF TF:M11027 Factor: Six-1; motif: NCGTATCRNN 0.038783078922033 3180 16 8 0.5 0.00251572327044025
TF TF:M02044_1 Factor: YY1; motif: GCCGCCATTTTG; match class: 1 0.038783078922033 1198 65 11 0.169230769230769 0.00918196994991653
TF TF:M09960 Factor: IRF-8; motif: NNAARRGGAASTGAAASTNN 0.038783078922033 282 17 3 0.176470588235294 0.0106382978723404
TF TF:M00069_1 Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW; match class: 1 0.038783078922033 2205 59 15 0.254237288135593 0.00680272108843537
TF TF:M10940 Factor: CHX10; motif: GCYAATTAY 0.0394671903716618 125 81 4 0.0493827160493827 0.032
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 0.0395643514908929 278 37 4 0.108108108108108 0.0143884892086331
TF TF:M10615 Factor: Dlx-5; motif: NTCRTTAN 0.0395643514908929 4413 98 35 0.357142857142857 0.00793111262179923
TF TF:M11450 Factor: Elf-1; motif: NANSCGGAAGTR 0.0395643514908929 5601 93 40 0.43010752688172 0.00714158186038207
TF TF:M08713 Factor: HOXB2:Net; motif: TAAYGNNNANCGGAAGTR 0.0395643514908929 149 32 3 0.09375 0.0201342281879195
TF TF:M11316 Factor: C/EBPbeta; motif: NRTTGCGYAAYN 0.0395643514908929 5225 11 8 0.727272727272727 0.0015311004784689
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.0404536755131532 8947 25 19 0.76 0.00212361685481167
TF TF:M10578 Factor: Barhl-1; motif: NTAAACGN 0.0410773091826479 6099 89 41 0.460674157303371 0.00672241351041154
TF TF:M08525 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM 0.0412159139891013 17065 98 94 0.959183673469388 0.00550835042484618
TF TF:M00652 Factor: NRF-1; motif: CGCATGCGCR 0.0412159139891013 1376 84 14 0.166666666666667 0.0101744186046512
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.0412159139891013 15268 89 80 0.898876404494382 0.00523971705527901
TF TF:M03793 Factor: IRF-7; motif: AARGGAAANNGAA 0.0412159139891013 1987 41 11 0.268292682926829 0.00553598389531958
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 0.0412159139891013 3795 40 16 0.4 0.00421607378129117
TF TF:M11002_1 Factor: LHX5; motif: NTCGTTAN; match class: 1 0.0412159139891013 114 91 4 0.043956043956044 0.0350877192982456
TF TF:M11015 Factor: ISL2; motif: SCACTTAN 0.0412769928490023 4207 13 8 0.615384615384615 0.00190159258378892
TF TF:M02074 Factor: GABPalpha; motif: RCCGGAWRYN 0.0413619169873689 4607 98 36 0.36734693877551 0.00781419578901671
TF TF:M04691_1 Factor: Kaiso; motif: TCTCGCGAG; match class: 1 0.0413619169873689 10488 39 30 0.769230769230769 0.0028604118993135
TF TF:M10575_1 Factor: Gbx2; motif: NTCRTTAN; match class: 1 0.0414347127409296 192 91 5 0.0549450549450549 0.0260416666666667
TF TF:M11987 Factor: NFATc3; motif: NAYGGAAANW 0.0414581054205077 2409 66 17 0.257575757575758 0.0070568700705687
TF TF:M00032_1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 1 0.0421001053046593 2161 92 20 0.217391304347826 0.00925497454881999
TF TF:M11754 Factor: HNF-4alpha; motif: RRGGTCAAAGGTCAN 0.0425523572881041 1336 87 14 0.160919540229885 0.0104790419161677
TF TF:M11714 Factor: TGIF2; motif: TGACANNTGTCA 0.0425523572881041 581 61 7 0.114754098360656 0.0120481927710843
TF TF:M11430_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0425523572881041 4902 96 37 0.385416666666667 0.00754793961648307
TF TF:M11922 Factor: Brn-4; motif: DNATGCRCATMW 0.0430118615817101 1874 70 15 0.214285714285714 0.0080042689434365
TF TF:M03966 Factor: ELF1; motif: AACCCGGAAGTR 0.0445088440763041 6610 43 24 0.558139534883721 0.00363086232980333
TF TF:M11922_1 Factor: Brn-4; motif: DNATGCRCATMW; match class: 1 0.0445472939199699 517 69 7 0.101449275362319 0.0135396518375242
TF TF:M07386_1 Factor: Lmx1; motif: RDNTAATT; match class: 1 0.0445711232644971 1358 35 8 0.228571428571429 0.00589101620029455
TF TF:M08575_1 Factor: GCMa:C/EBPbeta; motif: ATGCGGGTNNRTTGCGCAAY; match class: 1 0.0445711232644971 1690 12 5 0.416666666666667 0.0029585798816568
TF TF:M11425_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0448666893199219 2330 31 10 0.32258064516129 0.00429184549356223
TF TF:M11392_1 Factor: Erg; motif: NACCGGAARYN; match class: 1 0.0455986890460151 3233 86 25 0.290697674418605 0.00773275595422209
TF TF:M08960 Factor: PPARALPHA:RXR-ALPHA; motif: AWNTRGGTNAAAGGTCAN 0.0455986890460151 11671 89 66 0.741573033707865 0.0056550424128181
TF TF:M10758_1 Factor: HOXB1; motif: NTCRTTAN; match class: 1 0.0455986890460151 275 96 6 0.0625 0.0218181818181818
TF TF:M02072 Factor: Pet-1; motif: ACCGGAWRTN 0.0455986890460151 2395 96 22 0.229166666666667 0.00918580375782881
TF TF:M08222 Factor: Elk-1:HOXB13; motif: ACCGGAAGTNGTAAAN 0.0473688890744744 7653 93 50 0.537634408602151 0.00653338560041814
TF TF:M07415 Factor: Elf-1; motif: AWCCCGGAAGTN 0.0473688890744744 7978 96 53 0.552083333333333 0.00664326898972174
TF TF:M09755_1 Factor: ZNF295; motif: NYCYCWGCYYCCCN; match class: 1 0.0473688890744744 612 93 9 0.0967741935483871 0.0147058823529412
TF TF:M10948_1 Factor: rax; motif: NNCRTTAN; match class: 1 0.0473688890744744 5245 94 38 0.404255319148936 0.00724499523355577
TF TF:M09833_1 Factor: RXRALPHA; motif: CNNTGRCCTYTNN; match class: 1 0.0476937495206908 987 48 8 0.166666666666667 0.00810536980749747
TF TF:M10748_1 Factor: GSH2; motif: SYMATTAR; match class: 1 0.0477400594120497 369 73 6 0.0821917808219178 0.016260162601626
TF TF:M11439 Factor: Net; motif: NRCCGGAAGTN 0.0477400594120497 2568 96 23 0.239583333333333 0.00895638629283489
TF TF:M11713_1 Factor: TGIF; motif: TGACAGCTGTCA; match class: 1 0.047885260232235 601 61 7 0.114754098360656 0.0116472545757072
TF TF:M07034 Factor: ATF-1; motif: NNNTGACGTNNN 0.047885260232235 4248 96 33 0.34375 0.0077683615819209
TF TF:M11400_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.047885260232235 4201 86 30 0.348837209302326 0.00714115686741252
TF TF:M11320 Factor: C/EBPdelta; motif: NRTTGCGYAAYN 0.047885260232235 5477 11 8 0.727272727272727 0.00146065364250502
TF TF:M08676_1 Factor: C/EBPgamma:Elf-1; motif: TKRCGHAATWSCGGAAGT; match class: 1 0.047885260232235 2364 6 4 0.666666666666667 0.00169204737732657
TF TF:M10632 Factor: Nkx2-8; motif: STCGTTGAN 0.047885260232235 4871 91 35 0.384615384615385 0.00718538287825908
TF TF:M00052 Factor: NF-kappaB; motif: GGGRATTTCC 0.047885260232235 1874 16 6 0.375 0.0032017075773746
TF TF:M02090 Factor: E2F-4; motif: GCGGGAAANA 0.047885260232235 11966 12 12 1 0.00100284138392111
TF TF:M11031 Factor: Six-2; motif: NCGTATCRNN 0.047885260232235 9204 96 59 0.614583333333333 0.00641025641025641
TF TF:M08626_1 Factor: TEF-3:C/EBPbeta; motif: RTTGCGYAAYNNNNNGGAATGY; match class: 1 0.047885260232235 1730 55 12 0.218181818181818 0.0069364161849711
TF TF:M04287_1 Factor: BARHL2; motif: NNTAAAYGNN; match class: 1 0.0481039980958574 713 52 7 0.134615384615385 0.00981767180925666
TF TF:M11881_1 Factor: pax-6; motif: NYACGCNTSANYGCNYN; match class: 1 0.0481822307758255 7158 92 47 0.510869565217391 0.00656607991058955
TF TF:M10799_1 Factor: HOXA10; motif: NRTCGTAAANN; match class: 1 0.0485618143394037 1078 98 13 0.13265306122449 0.0120593692022263
TF TF:M00514 Factor: ATF4; motif: CVTGACGYMABG 0.0485999688371251 5390 95 39 0.410526315789474 0.00723562152133581
TF TF:M10001 Factor: NF-E2p45; motif: NNRTGACTCAGCA 0.0488068640185439 143 38 3 0.0789473684210526 0.020979020979021
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 4.4509977035006e-17 105 71 18 0.253521126760563 0.171428571428571
WP WP:WP183 Proteasome Degradation 4.4509977035006e-17 64 96 17 0.177083333333333 0.265625
WP WP:WP4324 Mitochondrial complex I assembly model OXPHOS system 6.41221273349566e-16 56 69 14 0.202898550724638 0.25
WP WP:WP4396 Nonalcoholic fatty liver disease 2.48663202913514e-15 159 71 19 0.267605633802817 0.119496855345912
WP WP:WP623 Oxidative phosphorylation 2.41236342356657e-12 62 69 12 0.173913043478261 0.193548387096774
WP WP:WP78 TCA Cycle (aka Krebs or citric acid cycle) 4.34911953393475e-11 18 79 8 0.10126582278481 0.444444444444444
WP WP:WP2359 Parkin-Ubiquitin Proteasomal System pathway 2.33563024940577e-05 70 96 8 0.0833333333333333 0.114285714285714
WP WP:WP4290 Metabolic reprogramming in colon cancer 3.1043294774676e-05 44 74 6 0.0810810810810811 0.136363636363636
WP WP:WP3925 Amino Acid metabolism 0.0002800649294639 91 78 7 0.0897435897435897 0.0769230769230769
WP WP:WP4920 Mitochondrial CII Assembly 0.000285632416232787 8 71 3 0.0422535211267606 0.375
WP WP:WP5050 TCA cycle in senescence 0.000621339419865024 10 74 3 0.0405405405405405 0.3
WP WP:WP357 Fatty Acid Biosynthesis 0.000668677966574077 22 34 3 0.0882352941176471 0.136363636363636
WP WP:WP702 Metapathway biotransformation Phase I and II 0.0021841885484234 185 27 5 0.185185185185185 0.027027027027027
WP WP:WP2453 TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) 0.0021841885484234 16 74 3 0.0405405405405405 0.1875
WP WP:WP4595 Urea cycle and associated pathways 0.00696628035837061 24 74 3 0.0405405405405405 0.125
WP WP:WP534 Glycolysis and Gluconeogenesis 0.00860727013922146 45 44 3 0.0681818181818182 0.0666666666666667
WP WP:WP4352 Ciliary landscape 0.0104664647545262 218 67 7 0.104477611940299 0.0321100917431193
WP WP:WP465 Tryptophan metabolism 0.0136585482845876 42 60 3 0.05 0.0714285714285714

pEpi28 transcription factor target enrichment of top program genes

TF enrichment of pEpi28
Possible regulators of activation of pEpi28 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.