pS24 program activity among Stromal cells

Activation of pS24
pS24 gene program activation in Stromal cells.
Gene program activation of pS24 by different cell subtypes
pS24 gene program activation among cells of different subtypes (Stromal cells).

pS24 top program genes

Top genes of pS24 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS24 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS24
pS24 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0019221 cytokine-mediated signaling pathway 2.94858758525213e-06 810 29 12 0.413793103448276 0.0148148148148148
GO:BP GO:0007166 cell surface receptor signaling pathway 2.15979086645548e-05 3210 32 20 0.625 0.00623052959501558
GO:BP GO:0071345 cellular response to cytokine stimulus 4.1703495192672e-05 1132 29 12 0.413793103448276 0.0106007067137809
GO:BP GO:0071346 cellular response to interferon-gamma 5.52367110194777e-05 175 25 6 0.24 0.0342857142857143
GO:BP GO:0034097 response to cytokine 6.00653481921979e-05 1226 29 12 0.413793103448276 0.00978792822185971
GO:BP GO:0034341 response to interferon-gamma 7.19890248182604e-05 196 25 6 0.24 0.0306122448979592
GO:BP GO:0071310 cellular response to organic substance 8.12134687514067e-05 2776 40 20 0.5 0.00720461095100865
GO:BP GO:0070098 chemokine-mediated signaling pathway 0.000443316032362582 87 19 4 0.210526315789474 0.0459770114942529
GO:BP GO:1990868 response to chemokine 0.000498547450750936 97 19 4 0.210526315789474 0.0412371134020619
GO:BP GO:1990869 cellular response to chemokine 0.000498547450750936 97 19 4 0.210526315789474 0.0412371134020619
GO:BP GO:0032649 regulation of interferon-gamma production 0.000498547450750936 110 37 5 0.135135135135135 0.0454545454545455
GO:BP GO:0032609 interferon-gamma production 0.000568380924272854 115 37 5 0.135135135135135 0.0434782608695652
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 0.000911622937151894 88 25 4 0.16 0.0454545454545455
GO:BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 0.00104736738144386 96 25 4 0.16 0.0416666666666667
GO:BP GO:0070887 cellular response to chemical stimulus 0.00104736738144386 3393 40 20 0.5 0.00589448865310934
GO:BP GO:0010033 response to organic substance 0.00104736738144386 3412 40 20 0.5 0.00586166471277843
GO:BP GO:0032729 positive regulation of interferon-gamma production 0.0010948657553262 66 37 4 0.108108108108108 0.0606060606060606
GO:BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 0.0010948657553262 100 25 4 0.16 0.04
GO:BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 0.00116626100827547 103 25 4 0.16 0.0388349514563107
GO:BP GO:0006955 immune response 0.001828960932418 2311 25 12 0.48 0.00519255733448724
GO:BP GO:0048584 positive regulation of response to stimulus 0.00201574614073848 2344 25 12 0.48 0.00511945392491468
GO:BP GO:0019882 antigen processing and presentation 0.00235269612165284 234 28 5 0.178571428571429 0.0213675213675214
GO:BP GO:0002250 adaptive immune response 0.00249653273883576 689 25 7 0.28 0.0101596516690856
GO:BP GO:0050776 regulation of immune response 0.00307823244830057 996 25 8 0.32 0.00803212851405622
GO:BP GO:0002376 immune system process 0.00326579060854748 3278 29 15 0.517241379310345 0.00457596095179988
GO:BP GO:0050778 positive regulation of immune response 0.00389466050469435 753 25 7 0.28 0.00929614873837981
GO:BP GO:0002684 positive regulation of immune system process 0.00441205123221356 1065 25 8 0.32 0.00751173708920188
GO:BP GO:0006952 defense response 0.00557573965751079 1818 25 10 0.4 0.0055005500550055
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 0.00596863173983301 174 25 4 0.16 0.0229885057471264
GO:BP GO:0010718 positive regulation of epithelial to mesenchymal transition 0.00639289409886297 51 32 3 0.09375 0.0588235294117647
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00643651699983716 1455 37 11 0.297297297297297 0.00756013745704467
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.00643651699983716 182 25 4 0.16 0.021978021978022
GO:BP GO:0098542 defense response to other organism 0.00669979273614489 1218 37 10 0.27027027027027 0.00821018062397373
GO:BP GO:0048878 chemical homeostasis 0.00669979273614489 1229 51 12 0.235294117647059 0.00976403580146461
GO:BP GO:0009605 response to external stimulus 0.00684288361902456 2944 49 19 0.387755102040816 0.00645380434782609
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.00684288361902456 192 25 4 0.16 0.0208333333333333
GO:BP GO:0016477 cell migration 0.00717641841141223 1649 19 8 0.421052631578947 0.00485142510612492
GO:BP GO:0050900 leukocyte migration 0.00732867812534159 511 19 5 0.263157894736842 0.00978473581213307
GO:BP GO:0050852 T cell receptor signaling pathway 0.00777970929321116 203 25 4 0.16 0.0197044334975369
GO:BP GO:0007165 signal transduction 0.00777970929321116 6309 43 27 0.627906976744186 0.00427960057061341
GO:BP GO:0051707 response to other organism 0.00777970929321116 1592 25 9 0.36 0.00565326633165829
GO:BP GO:0043207 response to external biotic stimulus 0.00777970929321116 1594 25 9 0.36 0.00564617314930991
GO:BP GO:0003206 cardiac chamber morphogenesis 0.00787303202835749 120 17 3 0.176470588235294 0.025
GO:BP GO:0023052 signaling 0.00787303202835749 6810 33 23 0.696969696969697 0.00337738619676946
GO:BP GO:0007154 cell communication 0.00808633065966142 6829 33 23 0.696969696969697 0.00336798945672866
GO:BP GO:0009607 response to biotic stimulus 0.00811427047180323 1626 25 9 0.36 0.00553505535055351
GO:BP GO:0048583 regulation of response to stimulus 0.00811427047180323 4278 26 15 0.576923076923077 0.00350631136044881
GO:BP GO:0048518 positive regulation of biological process 0.00857608871836604 6363 37 24 0.648648648648649 0.00377180575200377
GO:BP GO:0072676 lymphocyte migration 0.00919415380558691 117 19 3 0.157894736842105 0.0256410256410256
GO:BP GO:0048870 cell motility 0.0102055283449466 1828 19 8 0.421052631578947 0.00437636761487965
GO:BP GO:0001819 positive regulation of cytokine production 0.0102055283449466 452 37 6 0.162162162162162 0.0132743362831858
GO:BP GO:0051674 localization of cell 0.0102055283449466 1828 19 8 0.421052631578947 0.00437636761487965
GO:BP GO:1990266 neutrophil migration 0.0102055283449466 124 19 3 0.157894736842105 0.0241935483870968
GO:BP GO:0045087 innate immune response 0.0105009477159774 998 25 7 0.28 0.00701402805611222
GO:BP GO:0002697 regulation of immune effector process 0.0106907954238492 461 37 6 0.162162162162162 0.0130151843817787
GO:BP GO:0002443 leukocyte mediated immunity 0.0116548483205778 877 14 5 0.357142857142857 0.00570125427594071
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0116850428885557 363 18 4 0.222222222222222 0.0110192837465565
GO:BP GO:0030334 regulation of cell migration 0.0116850428885557 999 42 9 0.214285714285714 0.00900900900900901
GO:BP GO:0048522 positive regulation of cellular process 0.0116850428885557 5757 48 27 0.5625 0.00468994267847837
GO:BP GO:0014009 glial cell proliferation 0.0120920323942006 55 48 3 0.0625 0.0545454545454545
GO:BP GO:0007186 G protein-coupled receptor signaling pathway 0.0120920323942006 1355 6 4 0.666666666666667 0.0029520295202952
GO:BP GO:0003205 cardiac chamber development 0.0121666108383492 161 17 3 0.176470588235294 0.0186335403726708
GO:BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0121666108383492 152 18 3 0.166666666666667 0.0197368421052632
GO:BP GO:0042221 response to chemical 0.0122337927427947 4781 51 25 0.490196078431373 0.00522903158335076
GO:BP GO:0030198 extracellular matrix organization 0.0122337927427947 401 17 4 0.235294117647059 0.00997506234413965
GO:BP GO:0043062 extracellular structure organization 0.0122337927427947 402 17 4 0.235294117647059 0.00995024875621891
GO:BP GO:0045229 external encapsulating structure organization 0.0122947926111399 404 17 4 0.235294117647059 0.0099009900990099
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0127426000394889 2255 25 10 0.4 0.00443458980044346
GO:BP GO:0042592 homeostatic process 0.0127878266443555 1981 54 15 0.277777777777778 0.00757193336698637
GO:BP GO:0097530 granulocyte migration 0.0127878266443555 151 19 3 0.157894736842105 0.0198675496688742
GO:BP GO:0051239 regulation of multicellular organismal process 0.0129832251536865 2861 47 17 0.361702127659574 0.00594197832925551
GO:BP GO:0008283 cell population proliferation 0.0129832251536865 2054 32 11 0.34375 0.0053554040895813
GO:BP GO:0002819 regulation of adaptive immune response 0.0138126530075339 167 18 3 0.166666666666667 0.0179640718562874
GO:BP GO:0040011 locomotion 0.0141616148912066 2028 19 8 0.421052631578947 0.00394477317554241
GO:BP GO:2000145 regulation of cell motility 0.0141949266994727 1061 42 9 0.214285714285714 0.00848256361922714
GO:BP GO:0043408 regulation of MAPK cascade 0.0141949266994727 730 37 7 0.189189189189189 0.00958904109589041
GO:BP GO:0006950 response to stress 0.0143300430552325 4170 26 14 0.538461538461538 0.00335731414868106
GO:BP GO:0001817 regulation of cytokine production 0.0143300430552325 806 44 8 0.181818181818182 0.00992555831265509
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0158378505092973 539 37 6 0.162162162162162 0.0111317254174397
GO:BP GO:0010717 regulation of epithelial to mesenchymal transition 0.0167138169855112 102 32 3 0.09375 0.0294117647058824
GO:BP GO:0032642 regulation of chemokine production 0.0171364010041021 94 37 3 0.0810810810810811 0.0319148936170213
GO:BP GO:0042593 glucose homeostasis 0.0171364010041021 248 32 4 0.125 0.0161290322580645
GO:BP GO:0030335 positive regulation of cell migration 0.0171364010041021 567 37 6 0.162162162162162 0.0105820105820106
GO:BP GO:0002699 positive regulation of immune effector process 0.0171364010041021 215 37 4 0.108108108108108 0.0186046511627907
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.0171364010041021 323 25 4 0.16 0.0123839009287926
GO:BP GO:0040012 regulation of locomotion 0.0171364010041021 1104 42 9 0.214285714285714 0.00815217391304348
GO:BP GO:0033500 carbohydrate homeostasis 0.0171364010041021 249 32 4 0.125 0.0160642570281124
GO:BP GO:0071347 cellular response to interleukin-1 0.0171364010041021 185 19 3 0.157894736842105 0.0162162162162162
GO:BP GO:0001816 cytokine production 0.0171364010041021 844 25 6 0.24 0.00710900473933649
GO:BP GO:0071674 mononuclear cell migration 0.0171364010041021 191 19 3 0.157894736842105 0.0157068062827225
GO:BP GO:0002253 activation of immune response 0.0171364010041021 568 25 5 0.2 0.00880281690140845
GO:BP GO:0051270 regulation of cellular component movement 0.0173990928331528 1141 42 9 0.214285714285714 0.00788781770376862
GO:BP GO:0048762 mesenchymal cell differentiation 0.017578988073014 234 60 5 0.0833333333333333 0.0213675213675214
GO:BP GO:0002682 regulation of immune system process 0.017712156233144 1617 25 8 0.32 0.00494743351886209
GO:BP GO:0002685 regulation of leukocyte migration 0.0178431453398034 211 18 3 0.166666666666667 0.014218009478673
GO:BP GO:0002702 positive regulation of production of molecular mediator of immune response 0.0178431453398034 100 37 3 0.0810810810810811 0.03
GO:BP GO:0006954 inflammatory response 0.0178431453398034 794 19 5 0.263157894736842 0.00629722921914358
GO:BP GO:0032602 chemokine production 0.0178966957894716 101 37 3 0.0810810810810811 0.0297029702970297
GO:BP GO:2000147 positive regulation of cell motility 0.0179851181090005 591 37 6 0.162162162162162 0.0101522842639594
GO:BP GO:0002252 immune effector process 0.0189446846981633 1309 18 6 0.333333333333333 0.00458365164247517
GO:BP GO:0042063 gliogenesis 0.0193972227509786 308 48 5 0.104166666666667 0.0162337662337662
GO:BP GO:0051272 positive regulation of cellular component movement 0.0193972227509786 604 37 6 0.162162162162162 0.00993377483443709
GO:BP GO:0040017 positive regulation of locomotion 0.0194641021323388 606 37 6 0.162162162162162 0.0099009900990099
GO:BP GO:0070555 response to interleukin-1 0.0201867939537072 215 19 3 0.157894736842105 0.013953488372093
GO:BP GO:0002696 positive regulation of leukocyte activation 0.0202617034464799 412 37 5 0.135135135135135 0.0121359223300971
GO:BP GO:0006928 movement of cell or subcellular component 0.0202617034464799 2311 19 8 0.421052631578947 0.00346170488965816
GO:BP GO:0097529 myeloid leukocyte migration 0.0210599953880727 221 19 3 0.157894736842105 0.0135746606334842
GO:BP GO:0003208 cardiac ventricle morphogenesis 0.0215644389290727 69 60 3 0.05 0.0434782608695652
GO:BP GO:0050867 positive regulation of cell activation 0.0222277919867977 424 37 5 0.135135135135135 0.0117924528301887
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.0222277919867977 375 25 4 0.16 0.0106666666666667
GO:BP GO:0051716 cellular response to stimulus 0.023324842479708 7781 33 23 0.696969696969697 0.00295591826243413
GO:BP GO:0001837 epithelial to mesenchymal transition 0.023355667571547 156 60 4 0.0666666666666667 0.0256410256410256
GO:BP GO:0042127 regulation of cell population proliferation 0.0241625897140321 1774 25 8 0.32 0.00450958286358512
GO:BP GO:0010628 positive regulation of gene expression 0.0241625897140321 1160 37 8 0.216216216216216 0.00689655172413793
GO:BP GO:0032874 positive regulation of stress-activated MAPK cascade 0.0241625897140321 121 37 3 0.0810810810810811 0.0247933884297521
GO:BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 0.0241625897140321 123 37 3 0.0810810810810811 0.024390243902439
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 0.0241625897140321 122 37 3 0.0810810810810811 0.0245901639344262
GO:BP GO:0008202 steroid metabolic process 0.0242707630752484 342 29 4 0.137931034482759 0.0116959064327485
GO:BP GO:0045321 leukocyte activation 0.0254453275559972 1332 48 10 0.208333333333333 0.00750750750750751
GO:BP GO:0002449 lymphocyte mediated immunity 0.0258003207273011 354 14 3 0.214285714285714 0.00847457627118644
GO:BP GO:0050896 response to stimulus 0.0258003207273011 9407 26 21 0.807692307692308 0.00223238014244711
GO:BP GO:0065008 regulation of biological quality 0.0265467428430863 4131 54 22 0.407407407407407 0.00532558702493343
GO:BP GO:0016125 sterol metabolic process 0.0269935399412947 171 29 3 0.103448275862069 0.0175438596491228
GO:BP GO:0000165 MAPK cascade 0.0269935399412947 935 37 7 0.189189189189189 0.00748663101604278
GO:BP GO:0060485 mesenchyme development 0.0272898061530597 291 36 4 0.111111111111111 0.013745704467354
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0278868509239287 717 48 7 0.145833333333333 0.0097629009762901
GO:BP GO:0002263 cell activation involved in immune response 0.0282864358041604 721 48 7 0.145833333333333 0.00970873786407767
GO:BP GO:0042110 T cell activation 0.0293715498879878 489 37 5 0.135135135135135 0.0102249488752556
GO:BP GO:0098609 cell-cell adhesion 0.0296694498940103 894 30 6 0.2 0.00671140939597315
GO:BP GO:0055082 cellular chemical homeostasis 0.0304982620731164 841 32 6 0.1875 0.00713436385255648
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.0305311449641104 309 36 4 0.111111111111111 0.0129449838187702
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0313887499869014 982 37 7 0.189189189189189 0.00712830957230143
GO:BP GO:0050870 positive regulation of T cell activation 0.0313887499869014 219 25 3 0.12 0.0136986301369863
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 0.0317347381292414 148 37 3 0.0810810810810811 0.0202702702702703
GO:BP GO:0071322 cellular response to carbohydrate stimulus 0.0317347381292414 148 37 3 0.0810810810810811 0.0202702702702703
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0350755738118807 477 25 4 0.16 0.00838574423480084
GO:BP GO:0002757 immune response-activating signal transduction 0.0350755738118807 477 25 4 0.16 0.00838574423480084
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.035403314155962 329 36 4 0.111111111111111 0.0121580547112462
GO:BP GO:0009967 positive regulation of signal transduction 0.0359131280186869 1598 37 9 0.243243243243243 0.00563204005006258
GO:BP GO:0051099 positive regulation of binding 0.0364304968341715 174 34 3 0.0882352941176471 0.0172413793103448
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.0371432919370741 241 25 3 0.12 0.012448132780083
GO:BP GO:0019725 cellular homeostasis 0.0378562134250617 981 39 7 0.179487179487179 0.00713557594291539
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.0378562134250617 1037 37 7 0.189189189189189 0.00675024108003857
GO:BP GO:0051098 regulation of binding 0.0384499203016172 365 34 4 0.117647058823529 0.010958904109589
GO:BP GO:0070663 regulation of leukocyte proliferation 0.0391764649455321 251 25 3 0.12 0.0119521912350598
GO:BP GO:0072657 protein localization to membrane 0.0393802546840594 665 10 3 0.3 0.00451127819548872
GO:BP GO:0009893 positive regulation of metabolic process 0.0396151086705272 3783 37 15 0.405405405405405 0.00396510705789056
GO:BP GO:0001775 cell activation 0.0396151086705272 1495 48 10 0.208333333333333 0.00668896321070234
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.0396151086705272 512 25 4 0.16 0.0078125
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0396151086705272 515 25 4 0.16 0.00776699029126214
GO:BP GO:0035556 intracellular signal transduction 0.0396151086705272 2772 40 13 0.325 0.00468975468975469
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.0432954326608662 760 40 6 0.15 0.00789473684210526
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.044411836080854 365 37 4 0.108108108108108 0.010958904109589
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0447623683826396 3483 37 14 0.378378378378378 0.00401952339936836
GO:BP GO:0006935 chemotaxis 0.0448664891167134 653 47 6 0.127659574468085 0.00918836140888208
GO:BP GO:0042330 taxis 0.0450078314282384 656 47 6 0.127659574468085 0.00914634146341463
GO:BP GO:0002440 production of molecular mediator of immune response 0.0450078314282384 189 37 3 0.0810810810810811 0.0158730158730159
GO:BP GO:0032872 regulation of stress-activated MAPK cascade 0.0451769055575202 190 37 3 0.0810810810810811 0.0157894736842105
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.0451769055575202 284 25 3 0.12 0.0105633802816901
GO:BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 0.0461829632519846 193 37 3 0.0810810810810811 0.0155440414507772
GO:BP GO:0050801 ion homeostasis 0.0461900197699125 808 51 7 0.137254901960784 0.00866336633663366
GO:BP GO:0002694 regulation of leukocyte activation 0.0480049281212344 610 37 5 0.135135135135135 0.00819672131147541
GO:BP GO:0007155 cell adhesion 0.0484028740082746 1492 36 8 0.222222222222222 0.00536193029490617
GO:BP GO:0022610 biological adhesion 0.0488957550074106 1499 36 8 0.222222222222222 0.00533689126084056
GO:BP GO:0010647 positive regulation of cell communication 0.0489945143960346 1777 37 9 0.243243243243243 0.00506471581316826
GO:BP GO:0023056 positive regulation of signaling 0.0494264653037406 1782 37 9 0.243243243243243 0.00505050505050505
GO:BP GO:0002703 regulation of leukocyte mediated immunity 0.0498254274776953 205 37 3 0.0810810810810811 0.0146341463414634
GO:CC GO:0042613 MHC class II protein complex 1.14261525186165e-06 16 25 4 0.16 0.25
GO:CC GO:0098553 lumenal side of endoplasmic reticulum membrane 1.96966855716347e-06 25 25 4 0.16 0.16
GO:CC GO:0042611 MHC protein complex 1.96966855716347e-06 24 25 4 0.16 0.166666666666667
GO:CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 1.96966855716347e-06 25 25 4 0.16 0.16
GO:CC GO:0098576 lumenal side of membrane 5.06112615425388e-06 33 25 4 0.16 0.121212121212121
GO:CC GO:0030669 clathrin-coated endocytic vesicle membrane 6.05517927761459e-06 36 25 4 0.16 0.111111111111111
GO:CC GO:0030133 transport vesicle 1.23877676279543e-05 414 56 10 0.178571428571429 0.0241545893719807
GO:CC GO:0030658 transport vesicle membrane 1.73413503436764e-05 209 28 6 0.214285714285714 0.0287081339712919
GO:CC GO:0045334 clathrin-coated endocytic vesicle 2.13295817249302e-05 54 25 4 0.16 0.0740740740740741
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 2.39136256660229e-05 57 25 4 0.16 0.0701754385964912
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 0.000136569828455581 90 25 4 0.16 0.0444444444444444
GO:CC GO:0032588 trans-Golgi network membrane 0.000137425878869969 94 25 4 0.16 0.0425531914893617
GO:CC GO:0098552 side of membrane 0.000137425878869969 619 32 8 0.25 0.012924071082391
GO:CC GO:0030665 clathrin-coated vesicle membrane 0.000274322731042441 114 25 4 0.16 0.0350877192982456
GO:CC GO:0030666 endocytic vesicle membrane 0.000886097745194077 159 25 4 0.16 0.0251572327044025
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.000886097745194077 158 25 4 0.16 0.0253164556962025
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.000986278662409969 166 25 4 0.16 0.0240963855421687
GO:CC GO:0030662 coated vesicle membrane 0.00119504915722862 177 25 4 0.16 0.0225988700564972
GO:CC GO:0030136 clathrin-coated vesicle 0.00158237430170668 193 25 4 0.16 0.0207253886010363
GO:CC GO:0005887 integral component of plasma membrane 0.00213860569057444 1645 36 11 0.305555555555556 0.00668693009118541
GO:CC GO:0000323 lytic vacuole 0.00273855890944538 712 25 6 0.24 0.00842696629213483
GO:CC GO:0098797 plasma membrane protein complex 0.00273855890944538 694 25 6 0.24 0.00864553314121038
GO:CC GO:0031226 intrinsic component of plasma membrane 0.00273855890944538 1726 36 11 0.305555555555556 0.00637311703360371
GO:CC GO:0005764 lysosome 0.00273855890944538 712 25 6 0.24 0.00842696629213483
GO:CC GO:0031224 intrinsic component of membrane 0.0027998174734757 5868 37 22 0.594594594594595 0.00374914792092706
GO:CC GO:0031300 intrinsic component of organelle membrane 0.0027998174734757 413 28 5 0.178571428571429 0.0121065375302663
GO:CC GO:0009986 cell surface 0.0027998174734757 899 37 8 0.216216216216216 0.00889877641824249
GO:CC GO:0005802 trans-Golgi network 0.0027998174734757 250 25 4 0.16 0.016
GO:CC GO:0005789 endoplasmic reticulum membrane 0.00364556633224019 1117 25 7 0.28 0.0062667860340197
GO:CC GO:0097708 intracellular vesicle 0.00364556633224019 2428 56 17 0.303571428571429 0.00700164744645799
GO:CC GO:0031410 cytoplasmic vesicle 0.00364556633224019 2424 56 17 0.303571428571429 0.00701320132013201
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00364556633224019 779 35 7 0.2 0.00898587933247754
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.00364556633224019 1122 25 7 0.28 0.00623885918003565
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.00383527755104977 1139 25 7 0.28 0.00614574187884109
GO:CC GO:0005773 vacuole 0.00383797254973042 810 25 6 0.24 0.00740740740740741
GO:CC GO:0005886 plasma membrane 0.00387018108986545 5681 37 21 0.567567567567568 0.00369653230065129
GO:CC GO:0005783 endoplasmic reticulum 0.00387018108986545 1982 25 9 0.36 0.00454086781029263
GO:CC GO:0012506 vesicle membrane 0.00387018108986545 800 35 7 0.2 0.00875
GO:CC GO:0030139 endocytic vesicle 0.00387018108986545 306 25 4 0.16 0.0130718954248366
GO:CC GO:0030135 coated vesicle 0.00387018108986545 295 25 4 0.16 0.0135593220338983
GO:CC GO:0016021 integral component of membrane 0.00392302013980429 5711 37 21 0.567567567567568 0.00367711434074593
GO:CC GO:0005576 extracellular region 0.00650795731017607 4567 21 12 0.571428571428571 0.00262754543463981
GO:CC GO:0098852 lytic vacuole membrane 0.00769329744395251 383 25 4 0.16 0.010443864229765
GO:CC GO:0031301 integral component of organelle membrane 0.00769329744395251 382 25 4 0.16 0.0104712041884817
GO:CC GO:0005765 lysosomal membrane 0.00769329744395251 383 25 4 0.16 0.010443864229765
GO:CC GO:0012505 endomembrane system 0.00971632556565108 4640 56 24 0.428571428571429 0.00517241379310345
GO:CC GO:0071944 cell periphery 0.010146236694511 6169 37 21 0.567567567567568 0.00340411736099854
GO:CC GO:0099503 secretory vesicle 0.0119605060959089 1020 55 9 0.163636363636364 0.00882352941176471
GO:CC GO:0005774 vacuolar membrane 0.0119605060959089 441 25 4 0.16 0.0090702947845805
GO:CC GO:0005768 endosome 0.012594030978423 987 28 6 0.214285714285714 0.0060790273556231
GO:CC GO:0005615 extracellular space 0.012594030978423 3594 21 10 0.476190476190476 0.00278241513633834
GO:CC GO:0031982 vesicle 0.0151157453278469 4055 35 15 0.428571428571429 0.00369913686806412
GO:CC GO:0010008 endosome membrane 0.0170173215214367 505 25 4 0.16 0.00792079207920792
GO:CC GO:0098796 membrane protein complex 0.0260569464559775 1322 25 6 0.24 0.00453857791225416
GO:CC GO:0031984 organelle subcompartment 0.0264543464504423 1773 25 7 0.28 0.00394811054709532
GO:CC GO:0070062 extracellular exosome 0.0279282787782424 2176 21 7 0.333333333333333 0.00321691176470588
GO:CC GO:0016020 membrane 0.0285008675349658 9838 37 27 0.72972972972973 0.00274446025614962
GO:CC GO:1903561 extracellular vesicle 0.0326701153482139 2261 21 7 0.333333333333333 0.00309597523219814
GO:CC GO:0043230 extracellular organelle 0.0326701153482139 2263 21 7 0.333333333333333 0.00309323906319046
GO:CC GO:0009897 external side of plasma membrane 0.0340709648961655 408 60 5 0.0833333333333333 0.0122549019607843
GO:CC GO:0030141 secretory granule 0.0375707235734259 851 55 7 0.127272727272727 0.0082256169212691
GO:MF GO:0042605 peptide antigen binding 2.43929013192657e-05 30 25 4 0.16 0.133333333333333
GO:MF GO:0140375 immune receptor activity 0.000320865665833408 133 29 5 0.172413793103448 0.037593984962406
GO:MF GO:0005102 signaling receptor binding 0.000548659483045123 1672 21 10 0.476190476190476 0.00598086124401914
GO:MF GO:0005126 cytokine receptor binding 0.000817358282530698 275 21 5 0.238095238095238 0.0181818181818182
GO:MF GO:0003823 antigen binding 0.0027974117524586 163 25 4 0.16 0.0245398773006135
GO:MF GO:0019955 cytokine binding 0.0027974117524586 138 29 4 0.137931034482759 0.0289855072463768
GO:MF GO:0042277 peptide binding 0.00449908881562357 314 29 5 0.172413793103448 0.0159235668789809
GO:MF GO:0033218 amide binding 0.0109669161057006 389 29 5 0.172413793103448 0.012853470437018
GO:MF GO:0019838 growth factor binding 0.0145287155497767 138 21 3 0.142857142857143 0.0217391304347826
GO:MF GO:0004896 cytokine receptor activity 0.0145287155497767 99 29 3 0.103448275862069 0.0303030303030303
GO:MF GO:0005125 cytokine activity 0.0239756642599427 235 19 3 0.157894736842105 0.0127659574468085
GO:MF GO:0008135 translation factor activity, RNA binding 0.0266012826919876 99 48 3 0.0625 0.0303030303030303
GO:MF GO:0044877 protein-containing complex binding 0.0266012826919876 1287 15 5 0.333333333333333 0.00388500388500389
GO:MF GO:0050839 cell adhesion molecule binding 0.0266012826919876 546 10 3 0.3 0.00549450549450549
GO:MF GO:0004888 transmembrane signaling receptor activity 0.0269093032503833 1269 29 7 0.241379310344828 0.00551615445232467
GO:MF GO:0001664 G protein-coupled receptor binding 0.028095216065891 292 19 3 0.157894736842105 0.0102739726027397
GO:MF GO:0090079 translation regulator activity, nucleic acid binding 0.0290952422385978 123 48 3 0.0625 0.024390243902439
GO:MF GO:0046914 transition metal ion binding 0.0294334413174437 1111 12 4 0.333333333333333 0.0036003600360036
GO:MF GO:0038023 signaling receptor activity 0.0313046619780077 1458 22 6 0.272727272727273 0.00411522633744856
GO:MF GO:0008270 zinc ion binding 0.0313046619780077 833 9 3 0.333333333333333 0.00360144057623049
GO:MF GO:0060089 molecular transducer activity 0.0313046619780077 1458 22 6 0.272727272727273 0.00411522633744856
GO:MF GO:0045182 translation regulator activity 0.0336685836374025 155 48 3 0.0625 0.0193548387096774
GO:MF GO:0048018 receptor ligand activity 0.0479430465162311 494 19 3 0.157894736842105 0.00607287449392713
GO:MF GO:0030546 signaling receptor activator activity 0.0486575353484025 501 19 3 0.157894736842105 0.00598802395209581
KEGG KEGG:04672 Intestinal immune network for IgA production 1.00648106329201e-05 45 25 5 0.2 0.111111111111111
KEGG KEGG:04940 Type I diabetes mellitus 1.00648106329201e-05 40 25 5 0.2 0.125
KEGG KEGG:05310 Asthma 3.80175426346701e-05 27 25 4 0.16 0.148148148148148
KEGG KEGG:05330 Allograft rejection 7.42447294364752e-05 34 25 4 0.16 0.117647058823529
KEGG KEGG:05332 Graft-versus-host disease 8.40545053653151e-05 37 25 4 0.16 0.108108108108108
KEGG KEGG:04640 Hematopoietic cell lineage 0.000143296940039459 95 25 5 0.2 0.0526315789473684
KEGG KEGG:05320 Autoimmune thyroid disease 0.000167392472921714 49 25 4 0.16 0.0816326530612245
KEGG KEGG:04659 Th17 cell differentiation 0.000167392472921714 104 25 5 0.2 0.0480769230769231
KEGG KEGG:05416 Viral myocarditis 0.00024951321931312 56 25 4 0.16 0.0714285714285714
KEGG KEGG:05321 Inflammatory bowel disease 0.000336787679171899 62 25 4 0.16 0.0645161290322581
KEGG KEGG:05322 Systemic lupus erythematosus 0.000386123832217782 132 25 5 0.2 0.0378787878787879
KEGG KEGG:04612 Antigen processing and presentation 0.000428576161568794 69 25 4 0.16 0.0579710144927536
KEGG KEGG:05140 Leishmaniasis 0.000467826250792909 72 25 4 0.16 0.0555555555555556
KEGG KEGG:04514 Cell adhesion molecules 0.000491301293365238 146 25 5 0.2 0.0342465753424658
KEGG KEGG:05323 Rheumatoid arthritis 0.000773686292663618 88 25 4 0.16 0.0454545454545455
KEGG KEGG:05164 Influenza A 0.000773686292663618 169 25 5 0.2 0.029585798816568
KEGG KEGG:04658 Th1 and Th2 cell differentiation 0.000773686292663618 89 25 4 0.16 0.0449438202247191
KEGG KEGG:05150 Staphylococcus aureus infection 0.000773686292663618 87 25 4 0.16 0.0459770114942529
KEGG KEGG:05145 Toxoplasmosis 0.00160119371115197 109 25 4 0.16 0.036697247706422
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 0.00215196566472764 216 25 5 0.2 0.0231481481481481
KEGG KEGG:04145 Phagosome 0.00223211419496874 147 37 5 0.135135135135135 0.0340136054421769
KEGG KEGG:04060 Cytokine-cytokine receptor interaction 0.00223211419496874 293 29 6 0.206896551724138 0.0204778156996587
KEGG KEGG:05152 Tuberculosis 0.00467373699099569 175 37 5 0.135135135135135 0.0285714285714286
KEGG KEGG:05169 Epstein-Barr virus infection 0.011734001349741 198 25 4 0.16 0.0202020202020202
REAC REAC:R-HSA-389948 PD-1 signaling 1.36013413914727e-05 24 25 4 0.16 0.166666666666667
REAC REAC:R-HSA-202433 Generation of second messenger molecules 1.36013413914727e-05 35 42 5 0.119047619047619 0.142857142857143
REAC REAC:R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 1.36013413914727e-05 20 25 4 0.16 0.2
REAC REAC:R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 1.36013413914727e-05 23 25 4 0.16 0.173913043478261
REAC REAC:R-HSA-388841 Costimulation by the CD28 family 0.000732817438186362 67 25 4 0.16 0.0597014925373134
REAC REAC:R-HSA-877300 Interferon gamma signaling 0.00171771111497596 87 25 4 0.16 0.0459770114942529
REAC REAC:R-HSA-202424 Downstream TCR signaling 0.0023477475494176 98 25 4 0.16 0.0408163265306122
REAC REAC:R-HSA-202403 TCR signaling 0.00286848186731574 120 42 5 0.119047619047619 0.0416666666666667
REAC REAC:R-HSA-2132295 MHC class II antigen presentation 0.00440966102349435 123 25 4 0.16 0.032520325203252
REAC REAC:R-HSA-913531 Interferon Signaling 0.0210688146330342 191 25 4 0.16 0.0209424083769634
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.0447579739730455 842 25 7 0.28 0.00831353919239905
TF TF:M08838_1 Factor: Sox-9; motif: MACARWGNNNYCNTTNW; match class: 1 0.0312314313973579 667 61 11 0.180327868852459 0.0164917541229385
WP WP:WP2328 Allograft Rejection 0.000718889581672232 88 25 5 0.2 0.0568181818181818
WP WP:WP4217 Ebola Virus Pathway on Host 0.000718889581672232 130 32 6 0.1875 0.0461538461538462

pS24 transcription factor target enrichment of top program genes

TF enrichment of pS24
TFs corrosponding to activation of pS24. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.