pTNI18 program activity among T/NK/ILC cells

Activation of pTNI18
pTNI18 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI18 by different cell subtypes
pTNI18 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI18 top program genes

Top genes of pTNI18 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI18 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI18
pTNI18 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002682 regulation of immune system process 7.83103970607272e-06 1617 65 23 0.353846153846154 0.0142238713667285
GO:BP GO:0046649 lymphocyte activation 7.83103970607272e-06 771 47 14 0.297872340425532 0.0181582360570687
GO:BP GO:0042110 T cell activation 2.07446755956987e-05 489 47 11 0.234042553191489 0.0224948875255624
GO:BP GO:0002376 immune system process 2.07446755956987e-05 3278 55 28 0.509090909090909 0.00854179377669311
GO:BP GO:0002694 regulation of leukocyte activation 2.07446755956987e-05 610 48 12 0.25 0.019672131147541
GO:BP GO:0006955 immune response 2.07446755956987e-05 2311 62 25 0.403225806451613 0.0108178277801817
GO:BP GO:0045321 leukocyte activation 2.07446755956987e-05 1332 48 17 0.354166666666667 0.0127627627627628
GO:BP GO:0050865 regulation of cell activation 3.54883007115708e-05 655 48 12 0.25 0.0183206106870229
GO:BP GO:0001775 cell activation 4.13354879763486e-05 1495 48 17 0.354166666666667 0.011371237458194
GO:BP GO:0050863 regulation of T cell activation 4.74992662647764e-05 337 47 9 0.191489361702128 0.0267062314540059
GO:BP GO:0002250 adaptive immune response 4.74992662647764e-05 689 48 12 0.25 0.0174165457184325
GO:BP GO:0002684 positive regulation of immune system process 7.71592396089446e-05 1065 54 15 0.277777777777778 0.0140845070422535
GO:BP GO:0051249 regulation of lymphocyte activation 0.000153578969202348 518 47 10 0.212765957446809 0.0193050193050193
GO:BP GO:0050776 regulation of immune response 0.000197800726147373 996 62 15 0.241935483870968 0.0150602409638554
GO:BP GO:0022407 regulation of cell-cell adhesion 0.000355064084043283 445 47 9 0.191489361702128 0.0202247191011236
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.000419890929753602 338 47 8 0.170212765957447 0.0236686390532544
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.000768016227837905 375 47 8 0.170212765957447 0.0213333333333333
GO:BP GO:0051707 response to other organism 0.000768016227837905 1592 5 5 1 0.00314070351758794
GO:BP GO:0043207 response to external biotic stimulus 0.000768016227837905 1594 5 5 1 0.00313676286072773
GO:BP GO:0048583 regulation of response to stimulus 0.000768016227837905 4278 85 39 0.458823529411765 0.0091164095371669
GO:BP GO:0009607 response to biotic stimulus 0.000784651683996736 1626 5 5 1 0.0030750307503075
GO:BP GO:0002683 negative regulation of immune system process 0.00119429600770353 420 60 9 0.15 0.0214285714285714
GO:BP GO:0009617 response to bacterium 0.00168636049197407 743 5 4 0.8 0.0053835800807537
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.00354842649193404 2255 5 5 1 0.00221729490022173
GO:BP GO:0050896 response to stimulus 0.00358552383039712 9407 28 25 0.892857142857143 0.00265759540767514
GO:BP GO:0002695 negative regulation of leukocyte activation 0.00400117062786303 188 60 6 0.1 0.0319148936170213
GO:BP GO:0050856 regulation of T cell receptor signaling pathway 0.00592197945074553 42 91 4 0.043956043956044 0.0952380952380952
GO:BP GO:0050866 negative regulation of cell activation 0.00684710588210563 211 60 6 0.1 0.028436018957346
GO:BP GO:0098609 cell-cell adhesion 0.00766097742084849 894 47 10 0.212765957446809 0.0111856823266219
GO:BP GO:0071385 cellular response to glucocorticoid stimulus 0.00773114116890887 57 74 4 0.0540540540540541 0.0701754385964912
GO:BP GO:0048519 negative regulation of biological process 0.00773114116890887 5757 30 20 0.666666666666667 0.00347403161368768
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.00773114116890887 284 47 6 0.127659574468085 0.0211267605633803
GO:BP GO:0002696 positive regulation of leukocyte activation 0.00815019441790098 412 48 7 0.145833333333333 0.0169902912621359
GO:BP GO:0030155 regulation of cell adhesion 0.00821484786936734 748 47 9 0.191489361702128 0.0120320855614973
GO:BP GO:0009605 response to external stimulus 0.00821484786936734 2944 5 5 1 0.00169836956521739
GO:BP GO:0050867 positive regulation of cell activation 0.0083510250716661 424 48 7 0.145833333333333 0.0165094339622642
GO:BP GO:0071384 cellular response to corticosteroid stimulus 0.00882457842297019 63 74 4 0.0540540540540541 0.0634920634920635
GO:BP GO:0048585 negative regulation of response to stimulus 0.0110553586537062 1733 28 10 0.357142857142857 0.00577034045008656
GO:BP GO:0042267 natural killer cell mediated cytotoxicity 0.0123635401951821 62 83 4 0.0481927710843374 0.0645161290322581
GO:BP GO:0050852 T cell receptor signaling pathway 0.0126129977747058 203 48 5 0.104166666666667 0.0246305418719212
GO:BP GO:0043473 pigmentation 0.013102675508202 95 56 4 0.0714285714285714 0.0421052631578947
GO:BP GO:0002228 natural killer cell mediated immunity 0.013102675508202 65 83 4 0.0481927710843374 0.0615384615384615
GO:BP GO:0022610 biological adhesion 0.0137711955017761 1499 48 12 0.25 0.00800533689126084
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0137711955017761 783 72 11 0.152777777777778 0.0140485312899106
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.0137711955017761 544 22 5 0.227272727272727 0.00919117647058824
GO:BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 0.0137711955017761 68 91 4 0.043956043956044 0.0588235294117647
GO:BP GO:0023052 signaling 0.0137711955017761 6810 58 35 0.603448275862069 0.00513950073421439
GO:BP GO:0007155 cell adhesion 0.0137711955017761 1492 48 12 0.25 0.00804289544235925
GO:BP GO:0007154 cell communication 0.0137711955017761 6829 58 35 0.603448275862069 0.00512520134719578
GO:BP GO:0071396 cellular response to lipid 0.0137711955017761 578 44 7 0.159090909090909 0.0121107266435986
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.0137711955017761 156 41 4 0.0975609756097561 0.0256410256410256
GO:BP GO:0071549 cellular response to dexamethasone stimulus 0.0137711955017761 31 74 3 0.0405405405405405 0.0967741935483871
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.0137711955017761 365 47 6 0.127659574468085 0.0164383561643836
GO:BP GO:0050870 positive regulation of T cell activation 0.0137711955017761 219 47 5 0.106382978723404 0.0228310502283105
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.0137711955017761 241 47 5 0.106382978723404 0.020746887966805
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.0137711955017761 543 22 5 0.227272727272727 0.00920810313075507
GO:BP GO:0050794 regulation of cellular process 0.0137711955017761 11473 33 30 0.909090909090909 0.00261483482959993
GO:BP GO:0048523 negative regulation of cellular process 0.0137711955017761 5139 30 18 0.6 0.00350262697022767
GO:BP GO:0042461 photoreceptor cell development 0.0139040269586907 49 56 3 0.0535714285714286 0.0612244897959184
GO:BP GO:0050900 leukocyte migration 0.0139040269586907 511 65 8 0.123076923076923 0.0156555772994129
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 0.0139040269586907 119 55 4 0.0727272727272727 0.0336134453781513
GO:BP GO:0007165 signal transduction 0.0139191026395343 6309 58 33 0.568965517241379 0.00523062291963861
GO:BP GO:0033059 cellular pigmentation 0.0157648386590177 52 56 3 0.0535714285714286 0.0576923076923077
GO:BP GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 0.0157648386590177 25 117 3 0.0256410256410256 0.12
GO:BP GO:0071548 response to dexamethasone 0.0163056201910627 40 74 3 0.0405405405405405 0.075
GO:BP GO:0051336 regulation of hydrolase activity 0.0163137624971145 1321 72 14 0.194444444444444 0.0105980317940954
GO:BP GO:0042129 regulation of T cell proliferation 0.0164541590771077 176 41 4 0.0975609756097561 0.0227272727272727
GO:BP GO:0009892 negative regulation of metabolic process 0.0164541590771077 3479 27 13 0.481481481481481 0.00373670594998563
GO:BP GO:0043368 positive T cell selection 0.0170235728244856 38 83 3 0.036144578313253 0.0789473684210526
GO:BP GO:0010646 regulation of cell communication 0.0170984383464705 3543 30 14 0.466666666666667 0.00395145357042055
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.0173713941416678 512 54 7 0.12962962962963 0.013671875
GO:BP GO:0071363 cellular response to growth factor stimulus 0.0173713941416678 731 28 6 0.214285714285714 0.00820793433652531
GO:BP GO:0043087 regulation of GTPase activity 0.0173713941416678 493 72 8 0.111111111111111 0.0162271805273834
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0173713941416678 3210 55 20 0.363636363636364 0.00623052959501558
GO:BP GO:0023051 regulation of signaling 0.0174027459295826 3578 30 14 0.466666666666667 0.00391280044717719
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0177110681046582 515 54 7 0.12962962962963 0.0135922330097087
GO:BP GO:0045785 positive regulation of cell adhesion 0.0184401829599618 437 47 6 0.127659574468085 0.0137299771167048
GO:BP GO:0070848 response to growth factor 0.0187426997207033 759 28 6 0.214285714285714 0.00790513833992095
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0205855575550274 2719 16 8 0.5 0.00294225818315557
GO:BP GO:0046530 photoreceptor cell differentiation 0.0206498687406513 65 56 3 0.0535714285714286 0.0461538461538462
GO:BP GO:0042098 T cell proliferation 0.0212455234185499 205 41 4 0.0975609756097561 0.0195121951219512
GO:BP GO:0098542 defense response to other organism 0.0212455234185499 1218 4 3 0.75 0.00246305418719212
GO:BP GO:0050777 negative regulation of immune response 0.0212455234185499 157 24 3 0.125 0.0191082802547771
GO:BP GO:0001906 cell killing 0.021260238298972 175 48 4 0.0833333333333333 0.0228571428571429
GO:BP GO:0043547 positive regulation of GTPase activity 0.0214521069409036 413 72 7 0.0972222222222222 0.0169491525423729
GO:BP GO:0050789 regulation of biological process 0.0222765561065512 12091 28 26 0.928571428571429 0.00215035977173104
GO:BP GO:1900101 regulation of endoplasmic reticulum unfolded protein response 0.0232504421741734 31 131 3 0.0229007633587786 0.0967741935483871
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.023803457091446 107 83 4 0.0481927710843374 0.0373831775700935
GO:BP GO:0042326 negative regulation of phosphorylation 0.0238405900104981 420 22 4 0.181818181818182 0.00952380952380952
GO:BP GO:0042113 B cell activation 0.0238405900104981 330 13 3 0.230769230769231 0.00909090909090909
GO:BP GO:0016601 Rac protein signal transduction 0.0241576071087247 40 104 3 0.0288461538461538 0.075
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.0245624459634351 323 48 5 0.104166666666667 0.0154798761609907
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0245624459634351 1103 55 10 0.181818181818182 0.00906618313689937
GO:BP GO:0045058 T cell selection 0.0250690475712491 51 83 3 0.036144578313253 0.0588235294117647
GO:BP GO:0071383 cellular response to steroid hormone stimulus 0.0250690475712491 210 44 4 0.0909090909090909 0.019047619047619
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.0260371273409876 230 41 4 0.0975609756097561 0.0173913043478261
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.0266110742221111 232 41 4 0.0975609756097561 0.0172413793103448
GO:BP GO:0071216 cellular response to biotic stimulus 0.0277184303054612 238 41 4 0.0975609756097561 0.0168067226890756
GO:BP GO:0002526 acute inflammatory response 0.0281683994781839 114 41 3 0.0731707317073171 0.0263157894736842
GO:BP GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.0289676442370594 63 75 3 0.04 0.0476190476190476
GO:BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0292115210534157 138 35 3 0.0857142857142857 0.0217391304347826
GO:BP GO:0070663 regulation of leukocyte proliferation 0.0292115210534157 251 41 4 0.0975609756097561 0.0159362549800797
GO:BP GO:0031343 positive regulation of cell killing 0.0297572533513586 59 83 3 0.036144578313253 0.0508474576271186
GO:BP GO:0009966 regulation of signal transduction 0.0305831702083751 3165 37 14 0.378378378378378 0.00442338072669826
GO:BP GO:0045862 positive regulation of proteolysis 0.0305831702083751 378 46 5 0.108695652173913 0.0132275132275132
GO:BP GO:0050868 negative regulation of T cell activation 0.0311609104554674 123 41 3 0.0731707317073171 0.024390243902439
GO:BP GO:0002757 immune response-activating signal transduction 0.0312537336064287 477 91 8 0.0879120879120879 0.0167714884696017
GO:BP GO:1903131 mononuclear cell differentiation 0.0312537336064287 430 41 5 0.121951219512195 0.0116279069767442
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0312537336064287 477 91 8 0.0879120879120879 0.0167714884696017
GO:BP GO:0051384 response to glucocorticoid 0.0313686557048513 146 35 3 0.0857142857142857 0.0205479452054795
GO:BP GO:0030510 regulation of BMP signaling pathway 0.0340853470292697 96 55 3 0.0545454545454545 0.03125
GO:BP GO:0046688 response to copper ion 0.0342919851829219 42 127 3 0.0236220472440945 0.0714285714285714
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.0345150603320392 3241 26 11 0.423076923076923 0.00339401419315026
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0345150603320392 1151 24 6 0.25 0.0052128583840139
GO:BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.0345150603320392 154 35 3 0.0857142857142857 0.0194805194805195
GO:BP GO:0045747 positive regulation of Notch signaling pathway 0.0345150603320392 57 94 3 0.0319148936170213 0.0526315789473684
GO:BP GO:0032729 positive regulation of interferon-gamma production 0.035258912308092 66 83 3 0.036144578313253 0.0454545454545455
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.035258912308092 2518 24 9 0.375 0.00357426528991263
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.035258912308092 760 131 13 0.099236641221374 0.0171052631578947
GO:BP GO:0048013 ephrin receptor signaling pathway 0.0367221860428066 88 130 4 0.0307692307692308 0.0454545454545455
GO:BP GO:0001819 positive regulation of cytokine production 0.0367718336195573 452 60 6 0.1 0.0132743362831858
GO:BP GO:0006952 defense response 0.0367718336195573 1818 4 3 0.75 0.00165016501650165
GO:BP GO:0031960 response to corticosteroid 0.0369860949231823 165 35 3 0.0857142857142857 0.0181818181818182
GO:BP GO:0001822 kidney development 0.0369860949231823 293 40 4 0.1 0.0136518771331058
GO:BP GO:0048732 gland development 0.0369860949231823 436 44 5 0.113636363636364 0.0114678899082569
GO:BP GO:0016050 vesicle organization 0.0370124311308683 341 56 5 0.0892857142857143 0.0146627565982405
GO:BP GO:0044264 cellular polysaccharide metabolic process 0.0371749576243462 107 110 4 0.0363636363636364 0.0373831775700935
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.0371749576243462 142 41 3 0.0731707317073171 0.0211267605633803
GO:BP GO:0046651 lymphocyte proliferation 0.0380447507213638 294 41 4 0.0975609756097561 0.0136054421768707
GO:BP GO:0072001 renal system development 0.0380447507213638 302 40 4 0.1 0.0132450331125828
GO:BP GO:0033673 negative regulation of kinase activity 0.0380447507213638 275 22 3 0.136363636363636 0.0109090909090909
GO:BP GO:0051716 cellular response to stimulus 0.0380447507213638 7781 42 27 0.642857142857143 0.00346999100372703
GO:BP GO:0032943 mononuclear cell proliferation 0.038534493970643 297 41 4 0.0975609756097561 0.0134680134680135
GO:BP GO:0050778 positive regulation of immune response 0.038534493970643 753 91 10 0.10989010989011 0.0132802124833997
GO:BP GO:0043583 ear development 0.0392375169638184 218 56 4 0.0714285714285714 0.018348623853211
GO:BP GO:0030098 lymphocyte differentiation 0.0393268901997517 376 33 4 0.121212121212121 0.0106382978723404
GO:BP GO:0030879 mammary gland development 0.0395149606075787 140 44 3 0.0681818181818182 0.0214285714285714
GO:BP GO:0030595 leukocyte chemotaxis 0.0395149606075787 227 124 6 0.0483870967741935 0.026431718061674
GO:BP GO:0031400 negative regulation of protein modification process 0.0395149606075787 578 22 4 0.181818181818182 0.0069204152249135
GO:BP GO:0065007 biological regulation 0.0395149606075787 12809 28 26 0.928571428571429 0.00202982278085721
GO:BP GO:0001817 regulation of cytokine production 0.0396902944936634 806 60 8 0.133333333333333 0.00992555831265509
GO:BP GO:0002437 inflammatory response to antigenic stimulus 0.0396902944936634 65 96 3 0.03125 0.0461538461538462
GO:BP GO:0009791 post-embryonic development 0.0402684848147282 84 75 3 0.04 0.0357142857142857
GO:BP GO:0048518 positive regulation of biological process 0.0409355604997225 6363 48 26 0.541666666666667 0.00408612289800409
GO:BP GO:1901184 regulation of ERBB signaling pathway 0.0414998481887248 97 131 4 0.0305343511450382 0.0412371134020619
GO:BP GO:0060326 cell chemotaxis 0.0419593235302258 310 124 7 0.0564516129032258 0.0225806451612903
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.0420361288834933 187 35 3 0.0857142857142857 0.0160427807486631
GO:BP GO:0005976 polysaccharide metabolic process 0.0422526554078871 117 110 4 0.0363636363636364 0.0341880341880342
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0423581433385332 982 73 10 0.136986301369863 0.010183299389002
GO:BP GO:0023057 negative regulation of signaling 0.0429022748924059 1471 28 7 0.25 0.00475866757307954
GO:BP GO:0051348 negative regulation of transferase activity 0.0432314134192808 310 22 3 0.136363636363636 0.00967741935483871
GO:BP GO:0050790 regulation of catalytic activity 0.0433520462581057 2545 30 10 0.333333333333333 0.00392927308447937
GO:BP GO:0070661 leukocyte proliferation 0.043607286157998 325 41 4 0.0975609756097561 0.0123076923076923
GO:BP GO:0033993 response to lipid 0.043955554981403 918 44 7 0.159090909090909 0.00762527233115468
GO:BP GO:0001655 urogenital system development 0.044418504550883 337 40 4 0.1 0.0118694362017804
GO:BP GO:0001816 cytokine production 0.0445633475005059 844 60 8 0.133333333333333 0.00947867298578199
GO:BP GO:0006909 phagocytosis 0.0449747014774341 387 56 5 0.0892857142857143 0.0129198966408269
GO:BP GO:0002253 activation of immune response 0.0449747014774341 568 54 6 0.111111111111111 0.0105633802816901
GO:BP GO:0006984 ER-nucleus signaling pathway 0.0449747014774341 53 131 3 0.0229007633587786 0.0566037735849057
GO:BP GO:0002685 regulation of leukocyte migration 0.0452801808218227 211 65 4 0.0615384615384615 0.018957345971564
GO:BP GO:0030856 regulation of epithelial cell differentiation 0.0452801808218227 164 43 3 0.0697674418604651 0.0182926829268293
GO:BP GO:0002252 immune effector process 0.0453609860691694 1309 103 15 0.145631067961165 0.0114591291061879
GO:BP GO:0048699 generation of neurons 0.0455233159224973 1559 41 9 0.219512195121951 0.00577293136626042
GO:BP GO:0010952 positive regulation of peptidase activity 0.0457059974364163 205 35 3 0.0857142857142857 0.0146341463414634
GO:BP GO:0050793 regulation of developmental process 0.0459333164013635 2605 44 13 0.295454545454545 0.00499040307101727
GO:BP GO:0002520 immune system development 0.0459735733398196 1020 41 7 0.170731707317073 0.00686274509803922
GO:BP GO:1901655 cellular response to ketone 0.0459735733398196 97 74 3 0.0405405405405405 0.0309278350515464
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0464626599395204 1455 60 11 0.183333333333333 0.00756013745704467
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0464789990934171 385 37 4 0.108108108108108 0.0103896103896104
GO:BP GO:0002521 leukocyte differentiation 0.0467842183112667 550 41 5 0.121951219512195 0.00909090909090909
GO:BP GO:0018212 peptidyl-tyrosine modification 0.0470690318380674 388 37 4 0.108108108108108 0.0103092783505155
GO:BP GO:0097529 myeloid leukocyte migration 0.0480949853958672 221 65 4 0.0615384615384615 0.0180995475113122
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0486274100249052 217 35 3 0.0857142857142857 0.0138248847926267
GO:BP GO:0042127 regulation of cell population proliferation 0.0499527698744432 1774 44 10 0.227272727272727 0.0056369785794814
GO:CC GO:0098552 side of membrane 0.000264552959135806 619 52 11 0.211538461538462 0.0177705977382876
GO:CC GO:0009897 external side of plasma membrane 0.0194961756299691 408 52 7 0.134615384615385 0.017156862745098
GO:CC GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 0.0194961756299691 102 51 4 0.0784313725490196 0.0392156862745098
GO:CC GO:0097730 non-motile cilium 0.0409214248381339 163 56 4 0.0714285714285714 0.0245398773006135
GO:CC GO:0098797 plasma membrane protein complex 0.0409214248381339 694 52 7 0.134615384615385 0.0100864553314121
GO:CC GO:0098802 plasma membrane signaling receptor complex 0.0409214248381339 300 37 4 0.108108108108108 0.0133333333333333
GO:CC GO:0098857 membrane microdomain 0.0409214248381339 335 27 4 0.148148148148148 0.0119402985074627
GO:CC GO:0042101 T cell receptor complex 0.0409214248381339 134 33 3 0.0909090909090909 0.0223880597014925
GO:CC GO:0048770 pigment granule 0.0409214248381339 105 56 3 0.0535714285714286 0.0285714285714286
GO:CC GO:0045121 membrane raft 0.0409214248381339 335 27 4 0.148148148148148 0.0119402985074627
GO:CC GO:0042470 melanosome 0.0409214248381339 105 56 3 0.0535714285714286 0.0285714285714286
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0409214248381339 324 19 3 0.157894736842105 0.00925925925925926
GO:CC GO:0034774 secretory granule lumen 0.0409214248381339 320 19 3 0.157894736842105 0.009375
GO:CC GO:0031983 vesicle lumen 0.0409214248381339 326 19 3 0.157894736842105 0.00920245398773006
GO:CC GO:0035869 ciliary transition zone 0.0409214248381339 70 56 3 0.0535714285714286 0.0428571428571429
GO:CC GO:0019898 extrinsic component of membrane 0.0409214248381339 313 51 5 0.0980392156862745 0.0159744408945687
GO:CC GO:0097733 photoreceptor cell cilium 0.0498591902774838 118 56 3 0.0535714285714286 0.0254237288135593
GO:MF GO:0017124 SH3 domain binding 0.0234984548542099 129 85 5 0.0588235294117647 0.0387596899224806
GO:MF GO:0005515 protein binding 0.0234984548542099 14767 110 101 0.918181818181818 0.00683957472743279
GO:MF GO:0019900 kinase binding 0.0234984548542099 752 48 9 0.1875 0.011968085106383
GO:MF GO:0019899 enzyme binding 0.0294042845495383 2074 48 14 0.291666666666667 0.00675024108003857
MIRNA MIRNA:hsa-miR-512-5p hsa-miR-512-5p 0.0224579331760669 132 40 5 0.125 0.0378787878787879
MIRNA MIRNA:hsa-miR-214-3p hsa-miR-214-3p 0.0224579331760669 204 86 8 0.0930232558139535 0.0392156862745098
MIRNA MIRNA:hsa-miR-5186 hsa-miR-5186 0.0413529196077588 249 100 8 0.08 0.0321285140562249
MIRNA MIRNA:hsa-miR-6511a-5p hsa-miR-6511a-5p 0.0413529196077588 498 121 13 0.107438016528926 0.0261044176706827
MIRNA MIRNA:hsa-miR-1910-3p hsa-miR-1910-3p 0.0413529196077588 495 121 13 0.107438016528926 0.0262626262626263
MIRNA MIRNA:hsa-miR-616-5p hsa-miR-616-5p 0.0413529196077588 371 86 9 0.104651162790698 0.0242587601078167
MIRNA MIRNA:hsa-miR-371b-5p hsa-miR-371b-5p 0.0413529196077588 368 86 9 0.104651162790698 0.0244565217391304
MIRNA MIRNA:hsa-miR-5003-3p hsa-miR-5003-3p 0.0413529196077588 137 85 6 0.0705882352941176 0.0437956204379562
MIRNA MIRNA:hsa-miR-3619-5p hsa-miR-3619-5p 0.0413529196077588 148 85 6 0.0705882352941176 0.0405405405405405
MIRNA MIRNA:hsa-miR-373-5p hsa-miR-373-5p 0.0413529196077588 367 86 9 0.104651162790698 0.0245231607629428
MIRNA MIRNA:hsa-miR-761 hsa-miR-761 0.0413529196077588 150 85 6 0.0705882352941176 0.04
MIRNA MIRNA:hsa-miR-6736-3p hsa-miR-6736-3p 0.0413529196077588 242 119 9 0.0756302521008403 0.0371900826446281
MIRNA MIRNA:hsa-miR-630 hsa-miR-630 0.0467015206708153 76 119 5 0.0420168067226891 0.0657894736842105
MIRNA MIRNA:hsa-miR-922 hsa-miR-922 0.0470211533627295 160 14 3 0.214285714285714 0.01875
MIRNA MIRNA:hsa-miR-4328 hsa-miR-4328 0.0470211533627295 128 112 6 0.0535714285714286 0.046875

pTNI18 transcription factor target enrichment of top program genes

TF enrichment of pTNI18
TFs corrosponding to activation of pTNI18. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.