pEpi02 program activity among Epithelial cells

Activation of pEpi02
pEpi02 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi02 by different cell subtypes
pEpi02 gene program activation among cells of different subtypes (Epithelial cells).

pEpi02 top program genes

Top genes of pEpi02 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi02 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi02
pEpi02 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:306 Ribosome, cytoplasmic 9.10054079811282e-27 80 16 16 1 0.2
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 2.55925611373807e-15 47 16 10 0.625 0.212765957446809
CORUM CORUM:3055 Nop56p-associated pre-rRNA complex 7.88057795867001e-12 104 16 10 0.625 0.0961538461538462
CORUM CORUM:305 40S ribosomal subunit, cytoplasmic 5.81586671658324e-09 33 15 6 0.4 0.181818181818182
CORUM CORUM:338 40S ribosomal subunit, cytoplasmic 2.57935656518211e-07 31 15 5 0.333333333333333 0.161290322580645
CORUM CORUM:5380 TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) 3.91789372715959e-06 25 14 4 0.285714285714286 0.16
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 9.21573131562058e-35 96 16 16 1 0.166666666666667
GO:BP GO:0006613 cotranslational protein targeting to membrane 1.31971676018378e-34 102 16 16 1 0.156862745098039
GO:BP GO:0045047 protein targeting to ER 5.14233454845333e-34 113 16 16 1 0.141592920353982
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 7.00302197937895e-34 117 16 16 1 0.136752136752137
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 1.31730495614984e-33 123 16 16 1 0.130081300813008
GO:BP GO:0070972 protein localization to endoplasmic reticulum 2.01409199584499e-32 146 16 16 1 0.10958904109589
GO:BP GO:0019083 viral transcription 6.36980750928943e-31 181 16 16 1 0.0883977900552486
GO:BP GO:0019080 viral gene expression 2.70696759429426e-30 199 16 16 1 0.0804020100502513
GO:BP GO:0006413 translational initiation 2.84162677348557e-30 201 16 16 1 0.0796019900497512
GO:BP GO:0006612 protein targeting to membrane 3.27170938810116e-30 204 16 16 1 0.0784313725490196
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 6.58389553754504e-30 214 16 16 1 0.0747663551401869
GO:BP GO:0090150 establishment of protein localization to membrane 2.0792546075611e-26 351 16 16 1 0.0455840455840456
GO:BP GO:0006402 mRNA catabolic process 8.33033188712134e-26 384 16 16 1 0.0416666666666667
GO:BP GO:0006401 RNA catabolic process 3.89200406068089e-25 424 16 16 1 0.0377358490566038
GO:BP GO:0006605 protein targeting 6.8901445210322e-25 441 16 16 1 0.036281179138322
GO:BP GO:0034655 nucleobase-containing compound catabolic process 3.83117936708168e-23 567 16 16 1 0.0282186948853616
GO:BP GO:0072594 establishment of protein localization to organelle 5.82109631002352e-23 584 16 16 1 0.0273972602739726
GO:BP GO:0046700 heterocycle catabolic process 8.99156334034976e-23 602 16 16 1 0.026578073089701
GO:BP GO:0044270 cellular nitrogen compound catabolic process 1.00031483757433e-22 608 16 16 1 0.0263157894736842
GO:BP GO:0019439 aromatic compound catabolic process 1.41029804270155e-22 623 16 16 1 0.0256821829855538
GO:BP GO:1901361 organic cyclic compound catabolic process 2.73694518748366e-22 651 16 16 1 0.0245775729646697
GO:BP GO:0072657 protein localization to membrane 3.68659577608472e-22 665 16 16 1 0.0240601503759399
GO:BP GO:0006412 translation 3.32638831643995e-21 764 16 16 1 0.0209424083769634
GO:BP GO:0043043 peptide biosynthetic process 5.47399748802768e-21 790 16 16 1 0.020253164556962
GO:BP GO:0016071 mRNA metabolic process 2.68624491331505e-20 874 16 16 1 0.0183066361556064
GO:BP GO:0043604 amide biosynthetic process 7.28346090709836e-20 932 16 16 1 0.0171673819742489
GO:BP GO:0016032 viral process 8.33119807124323e-20 942 16 16 1 0.0169851380042463
GO:BP GO:0006518 peptide metabolic process 1.00210701771911e-19 955 16 16 1 0.0167539267015707
GO:BP GO:0044403 biological process involved in symbiotic interaction 2.0658558830569e-19 1001 16 16 1 0.015984015984016
GO:BP GO:0033365 protein localization to organelle 2.57866155901707e-19 1017 16 16 1 0.015732546705998
GO:BP GO:0006886 intracellular protein transport 2.96992452919126e-18 1186 16 16 1 0.0134907251264755
GO:BP GO:0044265 cellular macromolecule catabolic process 5.24023974285488e-18 1231 16 16 1 0.0129975629569456
GO:BP GO:0043603 cellular amide metabolic process 5.78829789057979e-18 1241 16 16 1 0.0128928283642224
GO:BP GO:0010629 negative regulation of gene expression 7.67770147447852e-17 1460 16 16 1 0.010958904109589
GO:BP GO:0009057 macromolecule catabolic process 8.14346437432268e-17 1468 16 16 1 0.0108991825613079
GO:BP GO:0046907 intracellular transport 1.55879450597166e-15 1767 16 16 1 0.00905489530277306
GO:BP GO:1901566 organonitrogen compound biosynthetic process 3.25452991452313e-15 1853 16 16 1 0.00863464651915812
GO:BP GO:0015031 protein transport 6.04407026298037e-15 1929 16 16 1 0.00829445308449974
GO:BP GO:0015833 peptide transport 8.32333949675384e-15 1971 16 16 1 0.00811770674784373
GO:BP GO:0042886 amide transport 1.08530287659722e-14 2007 16 16 1 0.00797209765819631
GO:BP GO:0034613 cellular protein localization 1.11972482513517e-14 2014 16 16 1 0.00794438927507448
GO:BP GO:0070727 cellular macromolecule localization 1.18356210364954e-14 2024 16 16 1 0.00790513833992095
GO:BP GO:0045184 establishment of protein localization 1.26117184566101e-14 2035 16 16 1 0.00786240786240786
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 6.40641090212518e-14 2255 16 16 1 0.00709534368070953
GO:BP GO:1901575 organic substance catabolic process 6.82114736621069e-14 2267 16 16 1 0.0070577856197618
GO:BP GO:0071705 nitrogen compound transport 9.8046077739127e-14 2322 16 16 1 0.00689061154177433
GO:BP GO:0044248 cellular catabolic process 1.13957869686774e-13 2347 16 16 1 0.00681721346399659
GO:BP GO:0002181 cytoplasmic translation 1.90165894107375e-13 103 16 8 0.5 0.0776699029126214
GO:BP GO:0042254 ribosome biogenesis 2.2431143675053e-13 307 16 10 0.625 0.0325732899022801
GO:BP GO:0009056 catabolic process 1.31532856817311e-12 2744 16 16 1 0.00583090379008746
GO:BP GO:0071702 organic substance transport 1.46580031524086e-12 2766 16 16 1 0.00578452639190166
GO:BP GO:0008104 protein localization 1.47133120434187e-12 2770 16 16 1 0.00577617328519856
GO:BP GO:0051649 establishment of localization in cell 1.84827247343422e-12 2813 16 16 1 0.00568787771062922
GO:BP GO:0006820 anion transport 2.78216067477472e-12 2889 16 16 1 0.00553824852890273
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 8.40095300400285e-12 446 16 10 0.625 0.0224215246636771
GO:BP GO:0033036 macromolecule localization 1.51305416334723e-11 3218 16 16 1 0.00497203231821007
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 1.66636756714654e-11 3241 16 16 1 0.00493674791730947
GO:BP GO:0009892 negative regulation of metabolic process 5.10184747000339e-11 3479 16 16 1 0.00459902270767462
GO:BP GO:0051641 cellular localization 6.65748937982073e-11 3541 16 16 1 0.00451849759954815
GO:BP GO:0006811 ion transport 1.11705840881509e-10 3661 16 16 1 0.0043703906036602
GO:BP GO:0042255 ribosome assembly 1.7367378393768e-10 64 16 6 0.375 0.09375
GO:BP GO:0042273 ribosomal large subunit biogenesis 4.20202692346373e-10 74 16 6 0.375 0.0810810810810811
GO:BP GO:0016070 RNA metabolic process 6.03675924906105e-09 4710 16 16 1 0.00339702760084926
GO:BP GO:0000028 ribosomal small subunit assembly 1.60946179944287e-08 19 15 4 0.266666666666667 0.210526315789474
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 1.60946179944287e-08 5017 16 16 1 0.00318915686665338
GO:BP GO:0034645 cellular macromolecule biosynthetic process 1.76625108387555e-08 5051 16 16 1 0.00316768956642249
GO:BP GO:0009059 macromolecule biosynthetic process 2.1221819807167e-08 5114 16 16 1 0.00312866640594447
GO:BP GO:0010468 regulation of gene expression 2.69801499248169e-08 5196 16 16 1 0.00307929176289453
GO:BP GO:0006810 transport 2.85989664008629e-08 5224 16 16 1 0.00306278713629403
GO:BP GO:0090304 nucleic acid metabolic process 2.85989664008629e-08 5226 16 16 1 0.00306161500191351
GO:BP GO:0044267 cellular protein metabolic process 2.85989664008629e-08 5229 16 16 1 0.00305985848154523
GO:BP GO:0042274 ribosomal small subunit biogenesis 3.56334535455885e-08 74 15 5 0.333333333333333 0.0675675675675676
GO:BP GO:0051234 establishment of localization 4.28577576963752e-08 5372 16 16 1 0.00297840655249442
GO:BP GO:0006364 rRNA processing 1.11098888844605e-07 224 14 6 0.428571428571429 0.0267857142857143
GO:BP GO:0006139 nucleobase-containing compound metabolic process 1.22630231182493e-07 5746 16 16 1 0.00278454577097111
GO:BP GO:0048519 negative regulation of biological process 1.24782103953969e-07 5757 16 16 1 0.00277922529095015
GO:BP GO:0022618 ribonucleoprotein complex assembly 1.29500469054695e-07 197 16 6 0.375 0.0304568527918782
GO:BP GO:0016072 rRNA metabolic process 1.36853989042633e-07 234 14 6 0.428571428571429 0.0256410256410256
GO:BP GO:0019538 protein metabolic process 1.38262526698737e-07 5808 16 16 1 0.00275482093663912
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 1.53589568089548e-07 204 16 6 0.375 0.0294117647058824
GO:BP GO:0046483 heterocycle metabolic process 1.75351134650533e-07 5904 16 16 1 0.002710027100271
GO:BP GO:0006725 cellular aromatic compound metabolic process 1.99338135881807e-07 5956 16 16 1 0.00268636668905306
GO:BP GO:0044249 cellular biosynthetic process 3.32546977925325e-07 6154 16 16 1 0.00259993500162496
GO:BP GO:0010467 gene expression 3.50636712260462e-07 6179 16 16 1 0.00258941576306846
GO:BP GO:1901360 organic cyclic compound metabolic process 3.6681264390867e-07 6201 16 16 1 0.00258022899532333
GO:BP GO:1901576 organic substance biosynthetic process 4.09163354152182e-07 6248 16 16 1 0.00256081946222791
GO:BP GO:0009058 biosynthetic process 5.11174238183213e-07 6340 16 16 1 0.00252365930599369
GO:BP GO:0034641 cellular nitrogen compound metabolic process 8.79216104123518e-07 6563 16 16 1 0.00243790949261009
GO:BP GO:0060255 regulation of macromolecule metabolic process 9.58205739098267e-07 6603 16 16 1 0.00242314099651673
GO:BP GO:1901564 organonitrogen compound metabolic process 1.48911525315117e-06 6792 16 16 1 0.00235571260306243
GO:BP GO:0051179 localization 1.90055485760907e-06 6901 16 16 1 0.00231850456455586
GO:BP GO:0034470 ncRNA processing 2.66957234229677e-06 397 14 6 0.428571428571429 0.0151133501259446
GO:BP GO:0019222 regulation of metabolic process 3.26633298042101e-06 7148 16 16 1 0.00223838836038053
GO:BP GO:0034660 ncRNA metabolic process 9.3023087293447e-06 493 14 6 0.428571428571429 0.0121703853955375
GO:BP GO:0000027 ribosomal large subunit assembly 1.90768738155926e-05 29 16 3 0.1875 0.103448275862069
GO:BP GO:0006396 RNA processing 2.70411677779049e-05 964 14 7 0.5 0.00726141078838174
GO:BP GO:0044260 cellular macromolecule metabolic process 4.0746572738855e-05 8390 16 16 1 0.00190703218116806
GO:BP GO:0044085 cellular component biogenesis 0.000177722004166482 3257 22 13 0.590909090909091 0.0039914031317163
GO:BP GO:0043170 macromolecule metabolic process 0.000477209668578661 9796 16 16 1 0.00163331972233565
GO:BP GO:0070925 organelle assembly 0.000664480979187459 895 16 6 0.375 0.00670391061452514
GO:BP GO:0006807 nitrogen compound metabolic process 0.000736853779926453 10078 16 16 1 0.00158761659059337
GO:BP GO:0044238 primary metabolic process 0.0015831445557224 10584 16 16 1 0.00151171579743008
GO:BP GO:0034622 cellular protein-containing complex assembly 0.00206784987475853 1107 16 6 0.375 0.00542005420054201
GO:BP GO:0044237 cellular metabolic process 0.00238348954485266 10871 16 16 1 0.00147180572164474
GO:BP GO:0071704 organic substance metabolic process 0.0045520019363245 11326 16 16 1 0.00141267879215963
GO:BP GO:0008152 metabolic process 0.00893404781647989 11827 16 16 1 0.00135283672951721
GO:BP GO:0050789 regulation of biological process 0.0123779104091991 12091 16 16 1 0.00132329832106526
GO:BP GO:0065003 protein-containing complex assembly 0.0167423868869548 1680 21 7 0.333333333333333 0.00416666666666667
GO:BP GO:0071840 cellular component organization or biogenesis 0.0255310809780652 6760 30 19 0.633333333333333 0.00281065088757396
GO:BP GO:0065007 biological regulation 0.0285939941992849 12809 16 16 1 0.00124912171129674
GO:BP GO:0043933 protein-containing complex subunit organization 0.0336721256787903 1963 16 6 0.375 0.00305654610290372
GO:BP GO:0022607 cellular component assembly 0.0402577368218605 3010 22 9 0.409090909090909 0.00299003322259136
GO:CC GO:0022626 cytosolic ribosome 8.46780739715429e-35 109 16 16 1 0.146788990825688
GO:CC GO:0044391 ribosomal subunit 5.110364817495e-31 190 16 16 1 0.0842105263157895
GO:CC GO:0005840 ribosome 2.31036819934977e-29 245 16 16 1 0.0653061224489796
GO:CC GO:1990904 ribonucleoprotein complex 3.5852926601622e-22 688 16 16 1 0.0232558139534884
GO:CC GO:0022625 cytosolic large ribosomal subunit 7.77236466449155e-21 57 16 10 0.625 0.175438596491228
GO:CC GO:0015934 large ribosomal subunit 1.43618189914185e-17 118 16 10 0.625 0.0847457627118644
GO:CC GO:0042788 polysomal ribosome 6.51434814691522e-16 34 12 7 0.583333333333333 0.205882352941176
GO:CC GO:0005844 polysome 1.54719617136447e-13 72 12 7 0.583333333333333 0.0972222222222222
GO:CC GO:0022627 cytosolic small ribosomal subunit 1.71244901040012e-11 47 15 6 0.4 0.127659574468085
GO:CC GO:0005925 focal adhesion 2.21172604047447e-10 420 16 9 0.5625 0.0214285714285714
GO:CC GO:0030055 cell-substrate junction 2.33095917373458e-10 427 16 9 0.5625 0.0210772833723653
GO:CC GO:0015935 small ribosomal subunit 2.38113820223757e-10 75 15 6 0.4 0.08
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 1.96837605446256e-08 5338 16 16 1 0.00299737729486699
GO:CC GO:0005829 cytosol 1.96837605446256e-08 5303 16 16 1 0.0030171600980577
GO:CC GO:0043228 non-membrane-bounded organelle 1.96837605446256e-08 5346 16 16 1 0.00299289188178077
GO:CC GO:0032991 protein-containing complex 3.34314281446703e-08 5548 16 16 1 0.00288392213410238
GO:CC GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane 4.27959398725402e-08 6 12 3 0.25 0.5
GO:CC GO:0070161 anchoring junction 5.45775106982492e-08 836 16 9 0.5625 0.0107655502392345
GO:CC GO:0030054 cell junction 7.82668834172379e-07 2105 16 11 0.6875 0.00522565320665083
GO:CC GO:0098554 cytoplasmic side of endoplasmic reticulum membrane 1.01492195745226e-06 16 12 3 0.25 0.1875
GO:CC GO:0030867 rough endoplasmic reticulum membrane 6.27787261390079e-06 29 12 3 0.25 0.103448275862069
GO:CC GO:0005791 rough endoplasmic reticulum 0.00016446036882531 86 12 3 0.25 0.0348837209302326
GO:CC GO:0014069 postsynaptic density 0.00119007472994091 334 16 4 0.25 0.0119760479041916
GO:CC GO:0032279 asymmetric synapse 0.00122132004908483 340 16 4 0.25 0.0117647058823529
GO:CC GO:0070062 extracellular exosome 0.00122686123652601 2176 16 8 0.5 0.00367647058823529
GO:CC GO:0043230 extracellular organelle 0.00135856610353909 2263 16 8 0.5 0.00353513035793195
GO:CC GO:0099572 postsynaptic specialization 0.00135856610353909 358 16 4 0.25 0.0111731843575419
GO:CC GO:1903561 extracellular vesicle 0.00135856610353909 2261 16 8 0.5 0.00353825740822645
GO:CC GO:0098984 neuron to neuron synapse 0.00135856610353909 366 16 4 0.25 0.0109289617486339
GO:CC GO:0098562 cytoplasmic side of membrane 0.00135856610353909 194 12 3 0.25 0.0154639175257732
GO:CC GO:0005737 cytoplasm 0.00314934490007636 11911 16 16 1 0.00134329611283687
GO:CC GO:0005615 extracellular space 0.00314934490007636 3594 18 10 0.555555555555556 0.00278241513633834
GO:CC GO:0045202 synapse 0.00314934490007636 1349 16 6 0.375 0.0044477390659748
GO:CC GO:0005576 extracellular region 0.00616782950013806 4567 21 12 0.571428571428571 0.00262754543463981
GO:CC GO:0043229 intracellular organelle 0.00637784002428876 12491 16 16 1 0.0012809222640301
GO:CC GO:0098794 postsynapse 0.00832661377917308 639 16 4 0.25 0.00625978090766823
GO:CC GO:0005783 endoplasmic reticulum 0.0196611204145384 1982 21 7 0.333333333333333 0.00353178607467205
GO:CC GO:0031982 vesicle 0.0260541665690409 4055 30 13 0.433333333333333 0.0032059186189889
GO:CC GO:0098552 side of membrane 0.0273561117828288 619 12 3 0.25 0.00484652665589661
GO:CC GO:0043226 organelle 0.0335998742003488 14008 16 16 1 0.00114220445459737
GO:CC GO:0070013 intracellular organelle lumen 0.0352786844972804 5402 27 14 0.518518518518518 0.00259163272861903
GO:CC GO:0031981 nuclear lumen 0.0352786844972804 4444 26 12 0.461538461538462 0.0027002700270027
GO:CC GO:0031974 membrane-enclosed lumen 0.0427894073534811 5565 27 14 0.518518518518518 0.00251572327044025
GO:CC GO:0043233 organelle lumen 0.0427894073534811 5565 27 14 0.518518518518518 0.00251572327044025
GO:MF GO:0003735 structural constituent of ribosome 1.92878912976654e-31 171 16 16 1 0.0935672514619883
GO:MF GO:0005198 structural molecule activity 9.93570108379669e-22 698 16 16 1 0.0229226361031519
GO:MF GO:0003723 RNA binding 9.62308424921578e-15 1943 16 16 1 0.00823468862583634
GO:MF GO:0003676 nucleic acid binding 2.25998194313264e-09 4276 16 16 1 0.00374181478016838
GO:MF GO:1901363 heterocyclic compound binding 7.48164743938954e-07 6228 16 16 1 0.00256904303147078
GO:MF GO:0097159 organic cyclic compound binding 7.66856989661551e-07 6309 16 16 1 0.00253605959740054
GO:MF GO:0019843 rRNA binding 0.000402050610369904 63 16 3 0.1875 0.0476190476190476
HP HP:0030270 Elevated red cell adenosine deaminase level 1.51398593287131e-16 22 15 9 0.6 0.409090909090909
HP HP:0020118 Radial artery aplasia 1.51398593287131e-16 22 15 9 0.6 0.409090909090909
HP HP:0031640 Abnormal radial artery morphology 1.51398593287131e-16 22 15 9 0.6 0.409090909090909
HP HP:0005532 Macrocytic dyserythropoietic anemia 1.86319283557927e-16 23 15 9 0.6 0.391304347826087
HP HP:0012133 Erythroid hypoplasia 3.0978191318007e-16 25 15 9 0.6 0.36
HP HP:0012410 Pure red cell aplasia 3.0978191318007e-16 25 15 9 0.6 0.36
HP HP:0006758 Malignant genitourinary tract tumor 4.05609665060862e-16 26 15 9 0.6 0.346153846153846
HP HP:0040276 Adenocarcinoma of the colon 5.31718911510498e-16 27 15 9 0.6 0.333333333333333
HP HP:0001227 Abnormality of the thenar eminence 9.06761818422508e-16 29 15 9 0.6 0.310344827586207
HP HP:0030272 Abnormal erythrocyte enzyme level 9.06761818422508e-16 29 15 9 0.6 0.310344827586207
HP HP:0011904 Persistence of hemoglobin F 1.07817221772574e-15 30 15 9 0.6 0.3
HP HP:0040275 Adenocarcinoma of the large intestine 1.07817221772574e-15 30 15 9 0.6 0.3
HP HP:0001895 Normochromic anemia 1.40068068833415e-15 31 15 9 0.6 0.290322580645161
HP HP:0002669 Osteosarcoma 2.3166688932035e-15 33 15 9 0.6 0.272727272727273
HP HP:0001896 Reticulocytopenia 2.3166688932035e-15 33 15 9 0.6 0.272727272727273
HP HP:0040273 Adenocarcinoma of the intestines 3.96658109692287e-15 35 15 9 0.6 0.257142857142857
HP HP:0009944 Partial duplication of thumb phalanx 6.56170821759209e-15 37 15 9 0.6 0.243243243243243
HP HP:0012131 Abnormal number of erythroid precursors 8.11058763351401e-15 38 15 9 0.6 0.236842105263158
HP HP:0005518 Increased mean corpuscular volume 9.47788584373195e-15 39 15 9 0.6 0.230769230769231
HP HP:0009999 Partial duplication of the phalanx of hand 9.47788584373195e-15 39 15 9 0.6 0.230769230769231
HP HP:0001790 Nonimmune hydrops fetalis 1.48867751433731e-14 41 15 9 0.6 0.219512195121951
HP HP:0009777 Absent thumb 2.86500525570141e-14 44 15 9 0.6 0.204545454545455
HP HP:0025065 Abnormal mean corpuscular volume 7.89361202404078e-14 49 15 9 0.6 0.183673469387755
HP HP:0001894 Thrombocytosis 9.21405279390158e-14 50 15 9 0.6 0.18
HP HP:0000912 Sprengel anomaly 1.07279043155206e-13 51 15 9 0.6 0.176470588235294
HP HP:0009942 Duplication of thumb phalanx 1.49893734995923e-13 53 15 9 0.6 0.169811320754717
HP HP:0011902 Abnormal hemoglobin 1.72999991989883e-13 54 15 9 0.6 0.166666666666667
HP HP:0001972 Macrocytic anemia 4.60366754624135e-13 60 15 9 0.6 0.15
HP HP:0001087 Developmental glaucoma 8.24050832740266e-13 64 15 9 0.6 0.140625
HP HP:0006749 Malignant gastrointestinal tract tumors 1.00123871811424e-12 66 15 9 0.6 0.136363636363636
HP HP:0009380 Aplasia of the fingers 1.00123871811424e-12 66 15 9 0.6 0.136363636363636
HP HP:0002672 Gastrointestinal carcinoma 1.00123871811424e-12 66 15 9 0.6 0.136363636363636
HP HP:0004808 Acute myeloid leukemia 1.08724133440942e-12 67 15 9 0.6 0.134328358208955
HP HP:0001199 Triphalangeal thumb 1.08724133440942e-12 67 15 9 0.6 0.134328358208955
HP HP:0004312 Abnormal reticulocyte morphology 2.08962855450565e-12 72 15 9 0.6 0.125
HP HP:0100273 Neoplasm of the colon 4.32112483368993e-12 78 15 9 0.6 0.115384615384615
HP HP:0000085 Horseshoe kidney 6.7232315511469e-12 82 15 9 0.6 0.109756097560976
HP HP:0001421 Abnormality of the musculature of the hand 1.40777559758497e-11 89 15 9 0.6 0.101123595505618
HP HP:0010622 Neoplasm of the skeletal system 2.06548767224845e-11 93 15 9 0.6 0.0967741935483871
HP HP:0001789 Hydrops fetalis 2.45412435643894e-11 95 15 9 0.6 0.0947368421052632
HP HP:0009778 Short thumb 3.19486072338568e-11 98 15 9 0.6 0.0918367346938776
HP HP:0002863 Myelodysplasia 4.1235619734577e-11 101 15 9 0.6 0.0891089108910891
HP HP:0002488 Acute leukemia 4.82851478636429e-11 103 15 9 0.6 0.087378640776699
HP HP:0000294 Low anterior hairline 5.15947757381269e-11 104 15 9 0.6 0.0865384615384615
HP HP:0100834 Neoplasm of the large intestine 6.0149369498128e-11 106 15 9 0.6 0.0849056603773585
HP HP:0000465 Webbed neck 8.99877319585268e-11 111 15 9 0.6 0.0810810810810811
HP HP:0001680 Coarctation of aorta 1.03800805342158e-10 113 15 9 0.6 0.079646017699115
HP HP:0009601 Aplasia/Hypoplasia of the thumb 2.70251951911064e-10 126 15 9 0.6 0.0714285714285714
HP HP:0000519 Developmental cataract 2.70251951911064e-10 126 15 9 0.6 0.0714285714285714
HP HP:0008551 Microtia 4.64581912947797e-10 134 15 9 0.6 0.0671641791044776
HP HP:0000980 Pallor 5.95406537310589e-10 138 15 9 0.6 0.0652173913043478
HP HP:0008772 Aplasia/Hypoplasia of the external ear 6.23612611818555e-10 139 15 9 0.6 0.0647482014388489
HP HP:0001909 Leukemia 7.91887017473749e-10 143 15 9 0.6 0.0629370629370629
HP HP:0008771 Aplasia/Hypoplasia of the ear 8.28011833031073e-10 144 15 9 0.6 0.0625
HP HP:0000599 Abnormality of the frontal hairline 9.62783720697881e-10 147 15 9 0.6 0.0612244897959184
HP HP:0000782 Abnormal scapula morphology 9.62783720697881e-10 147 15 9 0.6 0.0612244897959184
HP HP:0000185 Cleft soft palate 2.15517449075124e-09 161 15 9 0.6 0.0559006211180124
HP HP:0001875 Neutropenia 2.32764546469236e-09 163 15 9 0.6 0.0552147239263804
HP HP:0100542 Abnormal localization of kidney 2.32764546469236e-09 163 15 9 0.6 0.0552147239263804
HP HP:0100242 Sarcoma 2.51322379952878e-09 165 15 9 0.6 0.0545454545454545
HP HP:0010972 Anemia of inadequate production 2.51322379952878e-09 165 15 9 0.6 0.0545454545454545
HP HP:0000104 Renal agenesis 3.41176879475308e-09 171 15 9 0.6 0.0526315789473684
HP HP:0011991 Abnormal neutrophil count 3.9266069160163e-09 174 15 9 0.6 0.0517241379310345
HP HP:0009602 Abnormality of thumb phalanx 7.38279627833044e-09 187 15 9 0.6 0.0481283422459893
HP HP:0001254 Lethargy 7.99644930590206e-09 189 15 9 0.6 0.0476190476190476
HP HP:0009774 Triangular shaped phalanges of the hand 9.06830895589594e-09 192 15 9 0.6 0.046875
HP HP:0410030 Cleft lip 1.2305837906699e-08 199 15 9 0.6 0.0452261306532663
HP HP:0001446 Abnormality of the musculature of the upper limbs 1.38590016967782e-08 202 15 9 0.6 0.0445544554455446
HP HP:0100736 Abnormal soft palate morphology 1.62706431094951e-08 206 15 9 0.6 0.0436893203883495
HP HP:0009997 Duplication of phalanx of hand 1.74816608724071e-08 208 15 9 0.6 0.0432692307692308
HP HP:0004275 Duplication of hand bones 1.77386317501166e-08 209 15 9 0.6 0.0430622009569378
HP HP:0009142 Duplication of bones involving the upper extremities 1.77386317501166e-08 209 15 9 0.6 0.0430622009569378
HP HP:0009553 Abnormality of the hairline 2.07154625132015e-08 213 15 9 0.6 0.0422535211267606
HP HP:0032309 Abnormal granulocyte count 2.10218628848287e-08 214 15 9 0.6 0.0420560747663551
HP HP:0007379 Neoplasm of the genitourinary tract 2.10218628848287e-08 214 15 9 0.6 0.0420560747663551
HP HP:0001882 Leukopenia 2.44624116178035e-08 218 15 9 0.6 0.0412844036697248
HP HP:0001518 Small for gestational age 2.51478855191067e-08 219 15 9 0.6 0.0410958904109589
HP HP:0002250 Abnormal large intestine morphology 4.64252861328039e-08 235 15 9 0.6 0.0382978723404255
HP HP:0004377 Hematological neoplasm 5.523252144483e-08 240 15 9 0.6 0.0375
HP HP:0001874 Abnormality of neutrophils 7.55267717075418e-08 249 15 9 0.6 0.036144578313253
HP HP:0011361 Congenital abnormal hair pattern 8.58649976301909e-08 253 15 9 0.6 0.0355731225296443
HP HP:0007378 Neoplasm of the gastrointestinal tract 1.15435013556684e-07 262 15 9 0.6 0.0343511450381679
HP HP:0007700 Ocular anterior segment dysgenesis 2.38891048218004e-07 285 15 9 0.6 0.0315789473684211
HP HP:0009381 Short finger 2.48014302244871e-07 287 15 9 0.6 0.0313588850174216
HP HP:0010720 Abnormal hair pattern 2.48014302244871e-07 287 15 9 0.6 0.0313588850174216
HP HP:0001911 Abnormal granulocyte morphology 2.68508243725849e-07 290 15 9 0.6 0.0310344827586207
HP HP:0008678 Renal hypoplasia/aplasia 3.17521385641106e-07 296 15 9 0.6 0.0304054054054054
HP HP:0000047 Hypospadias 3.963036887798e-07 304 15 9 0.6 0.0296052631578947
HP HP:0010974 Abnormal myeloid leukocyte morphology 4.91531248109317e-07 312 15 9 0.6 0.0288461538461538
HP HP:0100037 Abnormality of the scalp hair 5.83245668996134e-07 319 15 9 0.6 0.0282131661442006
HP HP:0001679 Abnormal aortic morphology 5.83245668996134e-07 319 15 9 0.6 0.0282131661442006
HP HP:0100627 Displacement of the urethral meatus 5.86466210818811e-07 320 15 9 0.6 0.028125
HP HP:0032076 Abnormal male urethral meatus morphology 5.86466210818811e-07 320 15 9 0.6 0.028125
HP HP:0001873 Thrombocytopenia 6.16196470463438e-07 323 15 9 0.6 0.0278637770897833
HP HP:0000501 Glaucoma 6.16196470463438e-07 323 15 9 0.6 0.0278637770897833
HP HP:0011792 Neoplasm by histology 6.16196470463438e-07 323 15 9 0.6 0.0278637770897833
HP HP:0006265 Aplasia/Hypoplasia of fingers 6.26464050513725e-07 324 15 9 0.6 0.0277777777777778
HP HP:0001965 Abnormal scalp morphology 7.08368802015223e-07 329 15 9 0.6 0.027355623100304
HP HP:0000470 Short neck 7.1994867199835e-07 330 15 9 0.6 0.0272727272727273
HP HP:0011873 Abnormal platelet count 9.47356474391229e-07 341 15 9 0.6 0.0263929618768328
HP HP:0001172 Abnormal thumb morphology 9.86741539938172e-07 343 15 9 0.6 0.0262390670553936
HP HP:0011893 Abnormal leukocyte count 1.28407016584931e-06 354 15 9 0.6 0.0254237288135593
HP HP:0001631 Atrial septal defect 1.50602276304317e-06 361 15 9 0.6 0.0249307479224377
HP HP:0011994 Abnormal atrial septum morphology 1.56440775536443e-06 363 15 9 0.6 0.0247933884297521
HP HP:0004372 Reduced consciousness/confusion 1.66355774799795e-06 366 15 9 0.6 0.0245901639344262
HP HP:0003319 Abnormality of the cervical spine 1.76805463154509e-06 369 15 9 0.6 0.024390243902439
HP HP:0005922 Abnormal hand morphology 1.87813589161159e-06 372 15 9 0.6 0.0241935483870968
HP HP:0000795 Abnormality of the urethra 1.90428499058696e-06 373 15 9 0.6 0.0241286863270777
HP HP:0001872 Abnormal thrombocyte morphology 1.93083555518629e-06 374 15 9 0.6 0.0240641711229947
HP HP:0001629 Ventricular septal defect 2.45525767794475e-06 385 15 9 0.6 0.0233766233766234
HP HP:0010438 Abnormal ventricular septum morphology 2.90319818528951e-06 393 15 9 0.6 0.0229007633587786
HP HP:0005120 Abnormal cardiac atrium morphology 5.2917985935232e-06 422 15 9 0.6 0.0213270142180095
HP HP:0011004 Abnormal systemic arterial morphology 6.79296606772816e-06 435 15 9 0.6 0.0206896551724138
HP HP:0012379 Abnormal enzyme/coenzyme activity 8.32659224020261e-06 446 15 9 0.6 0.0201793721973094
HP HP:0009127 Abnormality of the musculature of the limbs 1.2415122093466e-05 468 15 9 0.6 0.0192307692307692
HP HP:0005927 Aplasia/hypoplasia involving bones of the hand 1.3707792146637e-05 474 15 9 0.6 0.0189873417721519
HP HP:0000286 Epicanthus 1.40827845607817e-05 476 15 9 0.6 0.0189075630252101
HP HP:0000969 Edema 1.75272569529918e-05 489 15 9 0.6 0.0184049079754601
HP HP:0000431 Wide nasal bridge 1.99243816425936e-05 497 15 9 0.6 0.0181086519114688
HP HP:0005280 Depressed nasal bridge 2.11362293819291e-05 501 15 9 0.6 0.0179640718562874
HP HP:0006496 Aplasia/hypoplasia involving bones of the upper limbs 2.24101732384607e-05 505 15 9 0.6 0.0178217821782178
HP HP:0001881 Abnormal leukocyte morphology 2.3946944674187e-05 510 15 9 0.6 0.0176470588235294
HP HP:0010987 Abnormal cellular immune system morphology 2.3946944674187e-05 510 15 9 0.6 0.0176470588235294
HP HP:0001903 Anemia 3.17635959164435e-05 528 15 9 0.6 0.0170454545454545
HP HP:0032251 Abnormal immune system morphology 3.35615301716532e-05 532 15 9 0.6 0.0169172932330827
HP HP:0011927 Short digit 3.60009476645718e-05 537 15 9 0.6 0.0167597765363128
HP HP:0001713 Abnormal cardiac ventricle morphology 3.68431126458383e-05 539 15 9 0.6 0.0166975881261596
HP HP:0000464 Abnormality of the neck 3.88808945669715e-05 543 15 9 0.6 0.0165745856353591
HP HP:0000175 Cleft palate 3.9780289706368e-05 545 15 9 0.6 0.0165137614678899
HP HP:0100737 Abnormal hard palate morphology 4.00820362367004e-05 546 15 9 0.6 0.0164835164835165
HP HP:0011032 Abnormality of fluid regulation 5.058199170395e-05 562 15 9 0.6 0.0160142348754448
HP HP:0001877 Abnormal erythrocyte morphology 5.81121544432202e-05 572 15 9 0.6 0.0157342657342657
HP HP:0001671 Abnormal cardiac septum morphology 5.93684566397e-05 574 15 9 0.6 0.0156794425087108
HP HP:0030962 Abnormal morphology of the great vessels 5.97816084716431e-05 575 15 9 0.6 0.0156521739130435
HP HP:0000202 Oral cleft 6.65313056620244e-05 583 15 9 0.6 0.0154373927958834
HP HP:0045060 Aplasia/hypoplasia involving bones of the extremities 8.14644158759877e-05 598 15 9 0.6 0.0150501672240803
HP HP:0005918 Abnormal finger phalanx morphology 0.000124866619060404 631 15 9 0.6 0.0142630744849445
HP HP:0000218 High palate 0.000124866619060404 631 15 9 0.6 0.0142630744849445
HP HP:0000036 Abnormal penis morphology 0.000127224774898077 633 15 9 0.6 0.014218009478673
HP HP:0000508 Ptosis 0.000136459094078018 639 15 9 0.6 0.0140845070422535
HP HP:0009815 Aplasia/hypoplasia of the extremities 0.000140783072745798 642 15 9 0.6 0.014018691588785
HP HP:0000316 Hypertelorism 0.000181780421899409 663 15 9 0.6 0.0135746606334842
HP HP:0000377 Abnormality of the pinna 0.000203885201556568 673 15 9 0.6 0.0133729569093611
HP HP:0000369 Low-set ears 0.000236477824072282 686 15 9 0.6 0.0131195335276968
HP HP:0000518 Cataract 0.000240452661141061 688 15 9 0.6 0.0130813953488372
HP HP:0000347 Micrognathia 0.000265294761248623 697 15 9 0.6 0.0129124820659971
HP HP:0010936 Abnormality of the lower urinary tract 0.000274099221324491 701 15 9 0.6 0.0128388017118402
HP HP:0009118 Aplasia/Hypoplasia of the mandible 0.000274099221324491 701 15 9 0.6 0.0128388017118402
HP HP:0000517 Abnormality of the lens 0.000291655684663927 707 15 9 0.6 0.0127298444130127
HP HP:0009116 Aplasia/Hypoplasia involving bones of the skull 0.000303199992798735 711 15 9 0.6 0.0126582278481013
HP HP:0000357 Abnormal location of ears 0.000337053966017358 721 15 9 0.6 0.0124826629680999
HP HP:0002242 Abnormal intestine morphology 0.000421636001209102 742 15 9 0.6 0.0121293800539084
HP HP:0000765 Abnormal thorax morphology 0.000605135940102855 777 15 9 0.6 0.0115830115830116
HP HP:0009122 Aplasia/hypoplasia affecting bones of the axial skeleton 0.000735524154063016 797 15 9 0.6 0.0112923462986198
HP HP:0033353 Abnormal blood vessel morphology 0.000745420800111224 799 15 9 0.6 0.0112640801001252
HP HP:0011793 Neoplasm by anatomical site 0.000755438092772512 801 15 9 0.6 0.0112359550561798
HP HP:0025015 Abnormal vascular morphology 0.000758070374291341 802 15 9 0.6 0.0112219451371571
HP HP:0002664 Neoplasm 0.00103502470033907 835 15 9 0.6 0.0107784431137725
HP HP:0001197 Abnormality of prenatal development or birth 0.00113967953899355 846 15 9 0.6 0.0106382978723404
HP HP:0100886 Abnormality of globe location 0.001652345215648 888 15 9 0.6 0.0101351351351351
HP HP:0000277 Abnormality of the mandible 0.00177556821631506 897 15 9 0.6 0.0100334448160535
HP HP:0000486 Strabismus 0.00187398134131266 904 15 9 0.6 0.00995575221238938
HP HP:0012210 Abnormal renal morphology 0.00194356267951437 909 15 9 0.6 0.0099009900990099
HP HP:0000422 Abnormal nasal bridge morphology 0.00219635359872119 925 15 9 0.6 0.00972972972972973
HP HP:0000549 Abnormal conjugate eye movement 0.00241033924585339 937 15 9 0.6 0.0096051227321238
HP HP:0030791 Abnormal jaw morphology 0.00244074352750919 940 15 9 0.6 0.00957446808510638
HP HP:0000290 Abnormality of the forehead 0.00244074352750919 940 15 9 0.6 0.00957446808510638
HP HP:0025033 Abnormality of digestive system morphology 0.00247164591443067 943 15 9 0.6 0.0095440084835631
HP HP:0012718 Morphological abnormality of the gastrointestinal tract 0.00247164591443067 943 15 9 0.6 0.0095440084835631
HP HP:0000174 Abnormal palate morphology 0.00277233259459233 958 15 9 0.6 0.00939457202505219
HP HP:0001167 Abnormality of finger 0.00403121664592861 1008 15 9 0.6 0.00892857142857143
HP HP:0000032 Abnormality of male external genitalia 0.00431740329757101 1018 15 9 0.6 0.00884086444007859
HP HP:0010461 Abnormality of the male genitalia 0.00534418333421413 1049 15 9 0.6 0.00857959961868446
HP HP:0009115 Aplasia/hypoplasia involving the skeleton 0.00535191398271029 1050 15 9 0.6 0.00857142857142857
HP HP:0000811 Abnormal external genitalia 0.00547493244604203 1054 15 9 0.6 0.00853889943074004
HP HP:0000356 Abnormality of the outer ear 0.00563972830331641 1059 15 9 0.6 0.0084985835694051
HP HP:0001595 Abnormal hair morphology 0.00704116356091892 1092 15 9 0.6 0.00824175824175824
HP HP:0011821 Abnormality of facial skeleton 0.00816332073441134 1115 15 9 0.6 0.00807174887892377
HP HP:0000492 Abnormal eyelid morphology 0.00822590903448869 1117 15 9 0.6 0.00805729632945389
HP HP:0000252 Microcephaly 0.00856416172828664 1124 15 9 0.6 0.00800711743772242
HP HP:0004328 Abnormal anterior eye segment morphology 0.0090290909437146 1133 15 9 0.6 0.00794351279788173
HP HP:0040195 Decreased head circumference 0.00927357506036231 1138 15 9 0.6 0.00790861159929701
HP HP:0005105 Abnormal nasal morphology 0.0103394055491061 1156 15 9 0.6 0.00778546712802768
HP HP:0000077 Abnormality of the kidney 0.0118785136947506 1181 15 9 0.6 0.00762066045723963
HP HP:0001871 Abnormality of blood and blood-forming tissues 0.0133321397847849 1201 15 9 0.6 0.00749375520399667
HP HP:0010935 Abnormality of the upper urinary tract 0.0138259858684848 1208 15 9 0.6 0.00745033112582781
HP HP:0004322 Short stature 0.0143339048769071 1215 15 9 0.6 0.00740740740740741
HP HP:0011138 Abnormality of skin adnexa morphology 0.0152945084886128 1227 15 9 0.6 0.00733496332518337
HP HP:0001627 Abnormal heart morphology 0.0167770288915548 1244 15 9 0.6 0.00723472668810289
HP HP:0012243 Abnormal reproductive system morphology 0.017762984368074 1255 15 9 0.6 0.00717131474103586
HP HP:0001155 Abnormality of the hand 0.0197608757452605 1276 15 9 0.6 0.00705329153605016
HP HP:0011297 Abnormal digit morphology 0.0205413601961163 1284 15 9 0.6 0.00700934579439252
HP HP:0004325 Decreased body weight 0.0205497983524987 1285 15 9 0.6 0.00700389105058366
HP HP:0030669 Abnormal ocular adnexa morphology 0.0221728454539536 1300 15 9 0.6 0.00692307692307692
HP HP:0000925 Abnormality of the vertebral column 0.0225395133321334 1304 15 9 0.6 0.00690184049079755
HP HP:0032039 Abnormality of the ocular adnexa 0.0237834821024776 1316 15 9 0.6 0.00683890577507599
HP HP:0000002 Abnormality of body height 0.0261322076607811 1335 15 9 0.6 0.00674157303370787
HP HP:0000315 Abnormality of the orbital region 0.0269650830835452 1343 15 9 0.6 0.00670141474311243
HP HP:0007364 Aplasia/Hypoplasia of the cerebrum 0.0272494912946352 1346 15 9 0.6 0.00668647845468053
HP HP:0012337 Abnormal homeostasis 0.0304587055881211 1370 15 9 0.6 0.00656934306569343
HP HP:0000240 Abnormality of skull size 0.0331267315594662 1388 15 9 0.6 0.00648414985590778
HP HP:0002817 Abnormality of the upper limb 0.0339512547726196 1395 15 9 0.6 0.00645161290322581
HP HP:0040068 Abnormality of limb bone 0.0458073382973544 1465 15 9 0.6 0.00614334470989761
HP HP:0002813 Abnormality of limb bone morphology 0.0458073382973544 1465 15 9 0.6 0.00614334470989761
HP HP:0000078 Abnormality of the genital system 0.0487655153737651 1480 15 9 0.6 0.00608108108108108
KEGG KEGG:03010 Ribosome 2.16081734052878e-27 153 16 16 1 0.104575163398693
KEGG KEGG:05171 Coronavirus disease - COVID-19 1.04287585729795e-24 231 16 16 1 0.0692640692640693
MIRNA MIRNA:hsa-miR-99a-5p hsa-miR-99a-5p 0.00474057213890581 131 7 3 0.428571428571429 0.0229007633587786
MIRNA MIRNA:hsa-miR-100-5p hsa-miR-100-5p 0.00474057213890581 250 10 4 0.4 0.016
MIRNA MIRNA:hsa-miR-766-3p hsa-miR-766-3p 0.0467659763949368 604 17 5 0.294117647058824 0.00827814569536424
REAC REAC:R-HSA-156902 Peptide chain elongation 1.24193730880287e-32 90 16 16 1 0.177777777777778
REAC REAC:R-HSA-192823 Viral mRNA Translation 1.24193730880287e-32 90 16 16 1 0.177777777777778
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 1.24193730880287e-32 94 16 16 1 0.170212765957447
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 1.24193730880287e-32 94 16 16 1 0.170212765957447
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 1.24193730880287e-32 94 16 16 1 0.170212765957447
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 1.49346891564902e-32 96 16 16 1 0.166666666666667
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 3.20802965813687e-32 102 16 16 1 0.156862745098039
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 3.20802965813687e-32 102 16 16 1 0.156862745098039
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 1.36366134760916e-31 113 16 16 1 0.141592920353982
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 1.36366134760916e-31 112 16 16 1 0.142857142857143
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1.36366134760916e-31 113 16 16 1 0.141592920353982
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.8086530882523e-31 116 16 16 1 0.137931034482759
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 1.8086530882523e-31 116 16 16 1 0.137931034482759
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 1.9455172186929e-31 117 16 16 1 0.136752136752137
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 2.62532219904833e-31 120 16 16 1 0.133333333333333
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 2.62532219904833e-31 120 16 16 1 0.133333333333333
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 1.42515460575563e-30 133 16 16 1 0.120300751879699
REAC REAC:R-HSA-168255 Influenza Infection 1.28759254174816e-29 152 16 16 1 0.105263157894737
REAC REAC:R-HSA-9711097 Cellular response to starvation 2.10331275257615e-29 157 16 16 1 0.101910828025478
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 8.37905081320989e-29 171 16 16 1 0.0935672514619883
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 2.48039362284033e-28 183 16 16 1 0.087431693989071
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.74960066699157e-28 193 16 16 1 0.0829015544041451
REAC REAC:R-HSA-72312 rRNA processing 1.27465366729388e-27 203 16 16 1 0.0788177339901478
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 3.69619456633029e-27 217 16 16 1 0.0737327188940092
REAC REAC:R-HSA-72766 Translation 4.75519645526386e-25 292 16 16 1 0.0547945205479452
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 2.02137684737317e-23 368 16 16 1 0.0434782608695652
REAC REAC:R-HSA-2262752 Cellular responses to stress 1.19689885036627e-20 546 16 16 1 0.0293040293040293
REAC REAC:R-HSA-422475 Axon guidance 1.26145002445673e-20 549 16 16 1 0.029143897996357
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 1.68027804468591e-20 560 16 16 1 0.0285714285714286
REAC REAC:R-HSA-9675108 Nervous system development 2.42410715525407e-20 574 16 16 1 0.0278745644599303
REAC REAC:R-HSA-8953854 Metabolism of RNA 2.14350818429174e-19 658 16 16 1 0.0243161094224924
REAC REAC:R-HSA-5663205 Infectious disease 6.60270354734578e-18 815 16 16 1 0.0196319018404908
REAC REAC:R-HSA-1266738 Developmental Biology 5.09149149552278e-16 1069 16 16 1 0.0149672591206735
REAC REAC:R-HSA-1643685 Disease 1.26939922832612e-13 1509 16 16 1 0.0106030483764082
REAC REAC:R-HSA-392499 Metabolism of proteins 8.31058830327153e-12 1961 16 16 1 0.00815910249872514
REAC REAC:R-HSA-1430728 Metabolism 1.92614052841352e-11 2070 16 16 1 0.00772946859903382
REAC REAC:R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 2.08279506886092e-10 52 15 6 0.4 0.115384615384615
REAC REAC:R-HSA-72702 Ribosomal scanning and start codon recognition 4.35081280983352e-10 59 15 6 0.4 0.101694915254237
REAC REAC:R-HSA-72649 Translation initiation complex formation 4.35081280983352e-10 59 15 6 0.4 0.101694915254237
REAC REAC:R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 4.70991739211386e-10 60 15 6 0.4 0.1
WP WP:WP477 Cytoplasmic Ribosomal Proteins 5.75084681600219e-31 90 16 16 1 0.177777777777778

pEpi02 transcription factor target enrichment of top program genes

TF enrichment of pEpi02
Possible regulators of activation of pEpi02 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.