pMA05 program activity among Mast cells

Activation of pMA05
pMA05 gene program activation in Mast cells.
Gene program activation of pMA05 by different cell subtypes
pMA05 gene program activation among cells of different subtypes (Mast cells).

pMA05 top program genes

Top genes of pMA05 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pMA05 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pMA05
pMA05 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:6442 Cytochrome c oxidase, mitochondrial 0.0020267196651214 14 22 3 0.136363636363636 0.214285714285714
CORUM CORUM:2914 Respiratory chain complex I (beta subunit) mitochondrial 0.0050102508723113 16 39 3 0.0769230769230769 0.1875
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 0.0050102508723113 47 26 4 0.153846153846154 0.0851063829787234
CORUM CORUM:5380 TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) 0.00508267301650593 25 26 3 0.115384615384615 0.12
CORUM CORUM:306 Ribosome, cytoplasmic 0.0123706877602294 80 26 4 0.153846153846154 0.05
CORUM CORUM:3055 Nop56p-associated pre-rRNA complex 0.0242290196207247 104 26 4 0.153846153846154 0.0384615384615385
GO:BP GO:0042773 ATP synthesis coupled electron transport 2.73160986983466e-08 100 41 8 0.195121951219512 0.08
GO:BP GO:0006119 oxidative phosphorylation 2.73160986983466e-08 151 41 9 0.219512195121951 0.0596026490066225
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 2.73160986983466e-08 99 41 8 0.195121951219512 0.0808080808080808
GO:BP GO:1902600 proton transmembrane transport 7.20973693334971e-08 157 32 8 0.25 0.0509554140127389
GO:BP GO:0022904 respiratory electron transport chain 7.20973693334971e-08 117 41 8 0.195121951219512 0.0683760683760684
GO:BP GO:0046034 ATP metabolic process 3.78678746378502e-07 314 41 10 0.24390243902439 0.0318471337579618
GO:BP GO:0006812 cation transport 9.40937032845493e-07 1197 32 14 0.4375 0.0116959064327485
GO:BP GO:0022900 electron transport chain 1.12807290891074e-06 180 41 8 0.195121951219512 0.0444444444444444
GO:BP GO:0019646 aerobic electron transport chain 1.19935396075178e-06 20 22 4 0.181818181818182 0.2
GO:BP GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 1.19935396075178e-06 20 22 4 0.181818181818182 0.2
GO:BP GO:0045333 cellular respiration 1.36179517852238e-06 192 41 8 0.195121951219512 0.0416666666666667
GO:BP GO:0006811 ion transport 3.96695394518116e-06 3661 32 21 0.65625 0.00573613766730402
GO:BP GO:0009060 aerobic respiration 5.48928613125584e-06 89 41 6 0.146341463414634 0.0674157303370786
GO:BP GO:0002283 neutrophil activation involved in immune response 5.83228464466197e-06 485 30 9 0.3 0.0185567010309278
GO:BP GO:0043312 neutrophil degranulation 5.83228464466197e-06 482 30 9 0.3 0.0186721991701245
GO:BP GO:0042119 neutrophil activation 6.45226254809654e-06 498 30 9 0.3 0.0180722891566265
GO:BP GO:0002446 neutrophil mediated immunity 6.45226254809654e-06 497 30 9 0.3 0.0181086519114688
GO:BP GO:0036230 granulocyte activation 6.74998644518033e-06 504 30 9 0.3 0.0178571428571429
GO:BP GO:0043299 leukocyte degranulation 1.06317324098674e-05 535 30 9 0.3 0.0168224299065421
GO:BP GO:0002275 myeloid cell activation involved in immune response 1.21932686648182e-05 547 30 9 0.3 0.0164533820840951
GO:BP GO:0002444 myeloid leukocyte mediated immunity 1.2352815346792e-05 551 30 9 0.3 0.0163339382940109
GO:BP GO:0006091 generation of precursor metabolites and energy 1.53884867172694e-05 538 41 10 0.24390243902439 0.0185873605947955
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 1.53884867172694e-05 289 41 8 0.195121951219512 0.027681660899654
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 1.53884867172694e-05 96 26 5 0.192307692307692 0.0520833333333333
GO:BP GO:0045055 regulated exocytosis 1.81512765724174e-05 785 30 10 0.333333333333333 0.0127388535031847
GO:BP GO:0006613 cotranslational protein targeting to membrane 1.81512765724174e-05 102 26 5 0.192307692307692 0.0490196078431373
GO:BP GO:0045047 protein targeting to ER 2.91437497907231e-05 113 26 5 0.192307692307692 0.0442477876106195
GO:BP GO:0006810 transport 3.12765272733095e-05 5224 32 23 0.71875 0.00440275650842266
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 3.22637407868268e-05 117 26 5 0.192307692307692 0.0427350427350427
GO:BP GO:0002274 myeloid leukocyte activation 4.3127169062914e-05 667 30 9 0.3 0.0134932533733133
GO:BP GO:0051234 establishment of localization 4.82551760742706e-05 5372 30 22 0.733333333333333 0.00409530900967982
GO:BP GO:0006887 exocytosis 5.27578452971429e-05 904 30 10 0.333333333333333 0.0110619469026549
GO:BP GO:0002366 leukocyte activation involved in immune response 7.14915623377867e-05 717 30 9 0.3 0.0125523012552301
GO:BP GO:0002263 cell activation involved in immune response 7.26593423637977e-05 721 30 9 0.3 0.0124826629680999
GO:BP GO:0070972 protein localization to endoplasmic reticulum 7.78016213422716e-05 146 26 5 0.192307692307692 0.0342465753424658
GO:BP GO:0051649 establishment of localization in cell 7.78016213422716e-05 2813 30 16 0.533333333333333 0.00568787771062922
GO:BP GO:0006754 ATP biosynthetic process 0.000161008616249305 59 10 3 0.3 0.0508474576271186
GO:BP GO:0055114 obsolete oxidation-reduction process 0.000185462834513358 745 41 10 0.24390243902439 0.0134228187919463
GO:BP GO:0098662 inorganic cation transmembrane transport 0.000243882860366054 794 32 9 0.28125 0.0113350125944584
GO:BP GO:0009206 purine ribonucleoside triphosphate biosynthetic process 0.000243882860366054 70 10 3 0.3 0.0428571428571429
GO:BP GO:0072657 protein localization to membrane 0.000244656657249711 665 29 8 0.275862068965517 0.0120300751879699
GO:BP GO:0009145 purine nucleoside triphosphate biosynthetic process 0.000244656657249711 71 10 3 0.3 0.0422535211267606
GO:BP GO:0002443 leukocyte mediated immunity 0.000279133396709897 877 30 9 0.3 0.0102622576966933
GO:BP GO:0009201 ribonucleoside triphosphate biosynthetic process 0.000284869866397523 76 10 3 0.3 0.0394736842105263
GO:BP GO:0006612 protein targeting to membrane 0.000312680634759625 204 26 5 0.192307692307692 0.0245098039215686
GO:BP GO:0009205 purine ribonucleoside triphosphate metabolic process 0.00035376801878884 84 10 3 0.3 0.0357142857142857
GO:BP GO:0009142 nucleoside triphosphate biosynthetic process 0.000385328920355966 87 10 3 0.3 0.0344827586206897
GO:BP GO:0009144 purine nucleoside triphosphate metabolic process 0.000418342055840353 90 10 3 0.3 0.0333333333333333
GO:BP GO:0009199 ribonucleoside triphosphate metabolic process 0.000424161178762137 91 10 3 0.3 0.032967032967033
GO:BP GO:0046903 secretion 0.000431508478134149 1501 30 11 0.366666666666667 0.00732844770153231
GO:BP GO:0098660 inorganic ion transmembrane transport 0.000431508478134149 883 32 9 0.28125 0.0101925254813137
GO:BP GO:0098655 cation transmembrane transport 0.000557916702157552 914 32 9 0.28125 0.00984682713347921
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 0.000726936657395173 123 26 4 0.153846153846154 0.032520325203252
GO:BP GO:0009141 nucleoside triphosphate metabolic process 0.000728241562268432 113 10 3 0.3 0.0265486725663717
GO:BP GO:0002252 immune effector process 0.000735427301764192 1309 30 10 0.333333333333333 0.00763941940412529
GO:BP GO:0006826 iron ion transport 0.000846101478927219 80 15 3 0.2 0.0375
GO:BP GO:0051641 cellular localization 0.00087979716148099 3541 30 16 0.533333333333333 0.00451849759954815
GO:BP GO:0032940 secretion by cell 0.000951301294753934 1364 30 10 0.333333333333333 0.00733137829912024
GO:BP GO:0000041 transition metal ion transport 0.000980673937355743 129 28 4 0.142857142857143 0.0310077519379845
GO:BP GO:0055072 iron ion homeostasis 0.000990734347389674 86 15 3 0.2 0.0348837209302326
GO:BP GO:0051179 localization 0.00119997216827432 6901 33 24 0.727272727272727 0.00347775684683379
GO:BP GO:0140352 export from cell 0.00123511515187361 1418 30 10 0.333333333333333 0.00705218617771509
GO:BP GO:0055085 transmembrane transport 0.00138553791301487 1635 32 11 0.34375 0.00672782874617737
GO:BP GO:0001775 cell activation 0.00183320116920643 1495 30 10 0.333333333333333 0.00668896321070234
GO:BP GO:0051050 positive regulation of transport 0.00186315445947148 923 30 8 0.266666666666667 0.00866738894907909
GO:BP GO:0034220 ion transmembrane transport 0.00187129742448684 1397 32 10 0.3125 0.00715819613457409
GO:BP GO:0009152 purine ribonucleotide biosynthetic process 0.00207671619119494 179 10 3 0.3 0.0167597765363128
GO:BP GO:0051100 negative regulation of binding 0.00209849245302295 163 11 3 0.272727272727273 0.0184049079754601
GO:BP GO:0019083 viral transcription 0.00219503505712975 181 26 4 0.153846153846154 0.0220994475138122
GO:BP GO:0090150 establishment of protein localization to membrane 0.00223223693908236 351 26 5 0.192307692307692 0.0142450142450142
GO:BP GO:0009260 ribonucleotide biosynthetic process 0.00227482360309448 192 10 3 0.3 0.015625
GO:BP GO:0046390 ribose phosphate biosynthetic process 0.00250126512920922 199 10 3 0.3 0.0150753768844221
GO:BP GO:0006164 purine nucleotide biosynthetic process 0.00258598925086871 202 10 3 0.3 0.0148514851485149
GO:BP GO:0045321 leukocyte activation 0.00281784448320803 1332 49 12 0.244897959183673 0.00900900900900901
GO:BP GO:0019080 viral gene expression 0.00285853494753578 199 26 4 0.153846153846154 0.0201005025125628
GO:BP GO:0072522 purine-containing compound biosynthetic process 0.00290843127249356 213 10 3 0.3 0.0140845070422535
GO:BP GO:0006413 translational initiation 0.00290843127249356 201 26 4 0.153846153846154 0.0199004975124378
GO:BP GO:0055076 transition metal ion homeostasis 0.00291735371333423 138 15 3 0.2 0.0217391304347826
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 0.00351851690568893 214 26 4 0.153846153846154 0.0186915887850467
GO:BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 0.00356227885317678 56 39 3 0.0769230769230769 0.0535714285714286
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 0.00412680430702555 80 29 3 0.103448275862069 0.0375
GO:BP GO:0006605 protein targeting 0.00512821370470863 441 26 5 0.192307692307692 0.0113378684807256
GO:BP GO:0009165 nucleotide biosynthetic process 0.00512821370470863 269 10 3 0.3 0.0111524163568773
GO:BP GO:1901293 nucleoside phosphate biosynthetic process 0.00529811860027797 273 10 3 0.3 0.010989010989011
GO:BP GO:0016192 vesicle-mediated transport 0.00616948360697635 2180 30 11 0.366666666666667 0.00504587155963303
GO:BP GO:0030837 negative regulation of actin filament polymerization 0.0069319479798137 68 42 3 0.0714285714285714 0.0441176470588235
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 0.0069319479798137 99 29 3 0.103448275862069 0.0303030303030303
GO:BP GO:0034613 cellular protein localization 0.00754012964660761 2014 33 11 0.333333333333333 0.0054617676266137
GO:BP GO:0070727 cellular macromolecule localization 0.00761354085548258 2024 33 11 0.333333333333333 0.00543478260869565
GO:BP GO:1903076 regulation of protein localization to plasma membrane 0.00762155700549585 105 29 3 0.103448275862069 0.0285714285714286
GO:BP GO:0051651 maintenance of location in cell 0.00843362621470415 223 33 4 0.121212121212121 0.0179372197309417
GO:BP GO:0006955 immune response 0.00916857056389333 2311 30 11 0.366666666666667 0.00475984422327997
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.00979314220026704 1001 29 7 0.241379310344828 0.00699300699300699
GO:BP GO:0032272 negative regulation of protein polymerization 0.0100567553304193 82 42 3 0.0714285714285714 0.0365853658536585
GO:BP GO:1904375 regulation of protein localization to cell periphery 0.0113704301664369 126 29 3 0.103448275862069 0.0238095238095238
GO:BP GO:0050778 positive regulation of immune response 0.0113704301664369 753 29 6 0.206896551724138 0.00796812749003984
GO:BP GO:0060326 cell chemotaxis 0.0117045626419347 310 46 5 0.108695652173913 0.0161290322580645
GO:BP GO:0051098 regulation of binding 0.0123311661195087 365 11 3 0.272727272727273 0.00821917808219178
GO:BP GO:0009150 purine ribonucleotide metabolic process 0.0129306673655806 414 10 3 0.3 0.0072463768115942
GO:BP GO:0072594 establishment of protein localization to organelle 0.0129799948912338 584 26 5 0.192307692307692 0.00856164383561644
GO:BP GO:0032418 lysosome localization 0.0133344334161917 76 52 3 0.0576923076923077 0.0394736842105263
GO:BP GO:0009259 ribonucleotide metabolic process 0.0137093708013145 431 10 3 0.3 0.00696055684454756
GO:BP GO:0033108 mitochondrial respiratory chain complex assembly 0.0137093708013145 103 39 3 0.0769230769230769 0.029126213592233
GO:BP GO:0007568 aging 0.0137093708013145 329 46 5 0.108695652173913 0.0151975683890578
GO:BP GO:0019693 ribose phosphate metabolic process 0.0139903777371996 441 10 3 0.3 0.00680272108843537
GO:BP GO:0006163 purine nucleotide metabolic process 0.0145034068560264 450 10 3 0.3 0.00666666666666667
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.0152173349344073 536 30 5 0.166666666666667 0.00932835820895522
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0161237644775886 2255 29 10 0.344827586206897 0.00443458980044346
GO:BP GO:0072521 purine-containing compound metabolic process 0.0161237644775886 473 10 3 0.3 0.00634249471458774
GO:BP GO:0030593 neutrophil chemotaxis 0.0161330389039697 103 43 3 0.0697674418604651 0.029126213592233
GO:BP GO:0006518 peptide metabolic process 0.0166701689943512 955 18 5 0.277777777777778 0.00523560209424084
GO:BP GO:0006402 mRNA catabolic process 0.0175426219715079 384 26 4 0.153846153846154 0.0104166666666667
GO:BP GO:0009617 response to bacterium 0.0176192228093892 743 23 5 0.217391304347826 0.00672947510094213
GO:BP GO:0065008 regulation of biological quality 0.0176794398524828 4131 15 9 0.6 0.00217864923747277
GO:BP GO:0097529 myeloid leukocyte migration 0.019012414674983 221 46 4 0.0869565217391304 0.0180995475113122
GO:BP GO:0006952 defense response 0.0192380643571927 1818 20 7 0.35 0.00385038503850385
GO:BP GO:0051235 maintenance of location 0.0193886999953927 337 15 3 0.2 0.00890207715133531
GO:BP GO:0030595 leukocyte chemotaxis 0.020146969628923 227 46 4 0.0869565217391304 0.0176211453744493
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 0.0203629935133728 174 29 3 0.103448275862069 0.0172413793103448
GO:BP GO:0050727 regulation of inflammatory response 0.0205983589234303 381 46 5 0.108695652173913 0.0131233595800525
GO:BP GO:0009117 nucleotide metabolic process 0.0208046437182886 544 10 3 0.3 0.00551470588235294
GO:BP GO:0006753 nucleoside phosphate metabolic process 0.0215999993016079 555 10 3 0.3 0.00540540540540541
GO:BP GO:0006401 RNA catabolic process 0.0216320551182876 424 26 4 0.153846153846154 0.00943396226415094
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.0219162068095511 182 29 3 0.103448275862069 0.0164835164835165
GO:BP GO:1990266 neutrophil migration 0.0224183353477099 124 43 3 0.0697674418604651 0.0241935483870968
GO:BP GO:0016032 viral process 0.0231328204663028 942 29 6 0.206896551724138 0.00636942675159236
GO:BP GO:0071621 granulocyte chemotaxis 0.0231328204663028 126 43 3 0.0697674418604651 0.0238095238095238
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.0241077705042298 192 29 3 0.103448275862069 0.015625
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0241077705042298 1107 42 8 0.19047619047619 0.00722673893405601
GO:BP GO:0090407 organophosphate biosynthetic process 0.0245648230054394 598 10 3 0.3 0.00501672240802676
GO:BP GO:0050776 regulation of immune response 0.025466243879624 996 20 5 0.25 0.00502008032128514
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.0254716124699972 1853 38 10 0.263157894736842 0.00539665407447383
GO:BP GO:1905475 regulation of protein localization to membrane 0.0254716124699972 201 29 3 0.103448275862069 0.0149253731343284
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 0.0264607543493269 629 10 3 0.3 0.00476947535771065
GO:BP GO:0065003 protein-containing complex assembly 0.0269116450726742 1680 42 10 0.238095238095238 0.00595238095238095
GO:BP GO:0043270 positive regulation of ion transport 0.0279992297303009 694 29 5 0.172413793103448 0.00720461095100865
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 0.0294417749951088 147 42 3 0.0714285714285714 0.0204081632653061
GO:BP GO:0030100 regulation of endocytosis 0.0307692201538478 212 30 3 0.1 0.0141509433962264
GO:BP GO:0002684 positive regulation of immune system process 0.0308591090486089 1065 20 5 0.25 0.00469483568075117
GO:BP GO:0006950 response to stress 0.0308591090486089 4170 22 11 0.5 0.0026378896882494
GO:BP GO:0031347 regulation of defense response 0.0311701641076446 704 55 7 0.127272727272727 0.00994318181818182
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.0313097967496689 686 10 3 0.3 0.0043731778425656
GO:BP GO:0006897 endocytosis 0.0313097967496689 696 30 5 0.166666666666667 0.00718390804597701
GO:BP GO:0097530 granulocyte migration 0.0322164212528939 151 43 3 0.0697674418604651 0.0198675496688742
GO:BP GO:0016310 phosphorylation 0.0337476058708003 2138 46 12 0.260869565217391 0.00561272217025257
GO:BP GO:0043603 cellular amide metabolic process 0.0344078248091825 1241 18 5 0.277777777777778 0.0040290088638195
GO:BP GO:0019882 antigen processing and presentation 0.0344305846368267 234 29 3 0.103448275862069 0.0128205128205128
GO:BP GO:0043269 regulation of ion transport 0.0351045519878067 1379 30 7 0.233333333333333 0.0050761421319797
GO:BP GO:0042742 defense response to bacterium 0.0351725184689027 349 20 3 0.15 0.00859598853868195
GO:BP GO:0051494 negative regulation of cytoskeleton organization 0.0364980548783031 166 42 3 0.0714285714285714 0.0180722891566265
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.0383545436565114 3087 22 9 0.409090909090909 0.00291545189504373
GO:BP GO:1902904 negative regulation of supramolecular fiber organization 0.0384550612859507 170 42 3 0.0714285714285714 0.0176470588235294
GO:BP GO:0016071 mRNA metabolic process 0.0388142062582953 874 26 5 0.192307692307692 0.005720823798627
GO:BP GO:0006793 phosphorus metabolic process 0.0396860502991995 3114 22 9 0.409090909090909 0.00289017341040462
GO:BP GO:0051049 regulation of transport 0.0402258521333173 1809 30 8 0.266666666666667 0.00442233278054174
GO:BP GO:0008104 protein localization 0.0402757325578987 2770 33 11 0.333333333333333 0.00397111913357401
GO:BP GO:0030833 regulation of actin filament polymerization 0.0407597123480298 177 42 3 0.0714285714285714 0.0169491525423729
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.0413943856109725 567 26 4 0.153846153846154 0.00705467372134039
GO:BP GO:0048584 positive regulation of response to stimulus 0.0423497661603756 2344 11 5 0.454545454545455 0.00213310580204778
GO:BP GO:0050878 regulation of body fluid levels 0.0431269397700834 514 29 4 0.137931034482759 0.00778210116731518
GO:BP GO:0098542 defense response to other organism 0.0439222239922973 1218 20 5 0.25 0.00410509031198686
GO:BP GO:0022898 regulation of transmembrane transporter activity 0.0439222239922973 281 28 3 0.107142857142857 0.0106761565836299
GO:BP GO:0007420 brain development 0.0461736682993212 754 32 5 0.15625 0.00663129973474801
GO:BP GO:0072659 protein localization to plasma membrane 0.0464581763141722 283 29 3 0.103448275862069 0.0106007067137809
GO:BP GO:0030832 regulation of actin filament length 0.0464581763141722 194 42 3 0.0714285714285714 0.0154639175257732
GO:BP GO:0008064 regulation of actin polymerization or depolymerization 0.0464581763141722 193 42 3 0.0714285714285714 0.0155440414507772
GO:BP GO:0046700 heterocycle catabolic process 0.0464581763141722 602 26 4 0.153846153846154 0.00664451827242525
GO:BP GO:0002376 immune system process 0.0464581763141722 3278 49 16 0.326530612244898 0.0048810250152532
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.0470715532059123 608 26 4 0.153846153846154 0.00657894736842105
GO:BP GO:0030041 actin filament polymerization 0.0472278093160859 196 42 3 0.0714285714285714 0.0153061224489796
GO:BP GO:0032409 regulation of transporter activity 0.0473141157319805 297 28 3 0.107142857142857 0.0101010101010101
GO:BP GO:0051707 response to other organism 0.049048274718818 1592 29 7 0.241379310344828 0.00439698492462312
GO:BP GO:0043207 response to external biotic stimulus 0.049048274718818 1594 29 7 0.241379310344828 0.00439146800501882
GO:BP GO:0019439 aromatic compound catabolic process 0.0492229942543621 623 26 4 0.153846153846154 0.00642054574638844
GO:CC GO:0070469 respirasome 1.29417155712851e-08 103 41 8 0.195121951219512 0.0776699029126214
GO:CC GO:0098803 respiratory chain complex 8.34258240088238e-08 86 41 7 0.170731707317073 0.0813953488372093
GO:CC GO:0070069 cytochrome complex 6.66084518611588e-07 34 41 5 0.121951219512195 0.147058823529412
GO:CC GO:0045277 respiratory chain complex IV 6.66084518611588e-07 21 22 4 0.181818181818182 0.19047619047619
GO:CC GO:0030141 secretory granule 1.90187398152435e-06 851 30 11 0.366666666666667 0.0129259694477086
GO:CC GO:0005743 mitochondrial inner membrane 3.84973125575713e-06 503 41 10 0.24390243902439 0.0198807157057654
GO:CC GO:0019866 organelle inner membrane 8.35016389595896e-06 564 41 10 0.24390243902439 0.0177304964539007
GO:CC GO:0099503 secretory vesicle 8.35016389595896e-06 1020 30 11 0.366666666666667 0.0107843137254902
GO:CC GO:0098796 membrane protein complex 1.02255560965196e-05 1322 41 14 0.341463414634146 0.010590015128593
GO:CC GO:0070062 extracellular exosome 1.02255560965196e-05 2176 31 15 0.483870967741935 0.00689338235294118
GO:CC GO:1903561 extracellular vesicle 1.15545238485757e-05 2261 31 15 0.483870967741935 0.00663423264042459
GO:CC GO:0098800 inner mitochondrial membrane protein complex 1.15545238485757e-05 146 41 6 0.146341463414634 0.0410958904109589
GO:CC GO:0005740 mitochondrial envelope 1.15545238485757e-05 797 41 11 0.268292682926829 0.013801756587202
GO:CC GO:0043230 extracellular organelle 1.15545238485757e-05 2263 31 15 0.483870967741935 0.0066283694211224
GO:CC GO:0022625 cytosolic large ribosomal subunit 1.67716032216825e-05 57 26 4 0.153846153846154 0.0701754385964912
GO:CC GO:0005746 mitochondrial respirasome 2.02379879107734e-05 89 41 5 0.121951219512195 0.0561797752808989
GO:CC GO:0031982 vesicle 2.46224899454043e-05 4055 31 19 0.612903225806452 0.00468557336621455
GO:CC GO:0005737 cytoplasm 3.8826046862928e-05 11911 34 33 0.970588235294118 0.00277054823272605
GO:CC GO:0031966 mitochondrial membrane 4.0306826377936e-05 746 41 10 0.24390243902439 0.0134048257372654
GO:CC GO:0070820 tertiary granule 5.26801847186669e-05 163 29 5 0.172413793103448 0.0306748466257669
GO:CC GO:1990204 oxidoreductase complex 5.26801847186669e-05 113 41 5 0.121951219512195 0.0442477876106195
GO:CC GO:0031975 envelope 5.33258093264818e-05 1237 46 13 0.282608695652174 0.0105092966855295
GO:CC GO:0031967 organelle envelope 5.33258093264818e-05 1237 46 13 0.282608695652174 0.0105092966855295
GO:CC GO:0005615 extracellular space 5.57459566552682e-05 3594 45 22 0.488888888888889 0.00612131329994435
GO:CC GO:0005576 extracellular region 5.79074565457711e-05 4567 45 25 0.555555555555556 0.00547405298883293
GO:CC GO:0032991 protein-containing complex 0.000109006117975897 5548 29 20 0.689655172413793 0.00360490266762797
GO:CC GO:0022626 cytosolic ribosome 0.000131935208794924 109 26 4 0.153846153846154 0.036697247706422
GO:CC GO:0015934 large ribosomal subunit 0.000174457128469062 118 26 4 0.153846153846154 0.0338983050847458
GO:CC GO:0098798 mitochondrial protein-containing complex 0.000205574012917115 270 41 6 0.146341463414634 0.0222222222222222
GO:CC GO:1990904 ribonucleoprotein complex 0.000239196484991321 688 26 7 0.269230769230769 0.0101744186046512
GO:CC GO:0062023 collagen-containing extracellular matrix 0.000380557672241512 421 19 5 0.263157894736842 0.0118764845605701
GO:CC GO:0034774 secretory granule lumen 0.00041675341685401 320 25 5 0.2 0.015625
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.000429785404715381 324 25 5 0.2 0.0154320987654321
GO:CC GO:0031983 vesicle lumen 0.000430556033656436 326 25 5 0.2 0.0153374233128834
GO:CC GO:0005766 primary lysosome 0.000626914218372952 154 30 4 0.133333333333333 0.025974025974026
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 0.000626914218372952 128 36 4 0.111111111111111 0.03125
GO:CC GO:0042582 azurophil granule 0.000626914218372952 154 30 4 0.133333333333333 0.025974025974026
GO:CC GO:0101002 ficolin-1-rich granule 0.000626914218372952 184 25 4 0.16 0.0217391304347826
GO:CC GO:0043229 intracellular organelle 0.000714500225486106 12491 34 32 0.941176470588235 0.0025618445280602
GO:CC GO:0044391 ribosomal subunit 0.000745631452920094 190 26 4 0.153846153846154 0.0210526315789474
GO:CC GO:0030964 NADH dehydrogenase complex 0.0008900936863974 51 39 3 0.0769230769230769 0.0588235294117647
GO:CC GO:0005747 mitochondrial respiratory chain complex I 0.0008900936863974 51 39 3 0.0769230769230769 0.0588235294117647
GO:CC GO:0045271 respiratory chain complex I 0.0008900936863974 51 39 3 0.0769230769230769 0.0588235294117647
GO:CC GO:0031012 extracellular matrix 0.00101908565757982 562 19 5 0.263157894736842 0.00889679715302491
GO:CC GO:0030312 external encapsulating structure 0.00101908565757982 563 19 5 0.263157894736842 0.0088809946714032
GO:CC GO:0005840 ribosome 0.00167501032067964 245 26 4 0.153846153846154 0.0163265306122449
GO:CC GO:0031090 organelle membrane 0.00198719603910277 3612 46 19 0.41304347826087 0.00526024363233666
GO:CC GO:0043226 organelle 0.00209682059640334 14008 34 33 0.970588235294118 0.00235579668760708
GO:CC GO:0043227 membrane-bounded organelle 0.00235149977268905 12858 32 30 0.9375 0.00233317778814746
GO:CC GO:0036464 cytoplasmic ribonucleoprotein granule 0.00235149977268905 237 13 3 0.230769230769231 0.0126582278481013
GO:CC GO:0035770 ribonucleoprotein granule 0.00261114498716065 248 13 3 0.230769230769231 0.0120967741935484
GO:CC GO:0012505 endomembrane system 0.00281862120599898 4640 30 16 0.533333333333333 0.00344827586206897
GO:CC GO:0005739 mitochondrion 0.00282506462010037 1673 41 11 0.268292682926829 0.00657501494321578
GO:CC GO:0097708 intracellular vesicle 0.00334097143592556 2428 30 11 0.366666666666667 0.00453047775947282
GO:CC GO:0031410 cytoplasmic vesicle 0.00334097143592556 2424 30 11 0.366666666666667 0.00453795379537954
GO:CC GO:0030667 secretory granule membrane 0.00523397035247762 303 30 4 0.133333333333333 0.0132013201320132
GO:CC GO:0005829 cytosol 0.0054923782899942 5303 26 15 0.576923076923077 0.0028285875919291
GO:CC GO:0005622 intracellular anatomical structure 0.00834327394546947 14790 34 33 0.970588235294118 0.00223123732251521
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00869279236611142 11296 32 27 0.84375 0.00239022662889518
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0205798019883573 779 30 5 0.166666666666667 0.00641848523748395
GO:CC GO:0012506 vesicle membrane 0.0221957316596057 800 30 5 0.166666666666667 0.00625
GO:CC GO:1902494 catalytic complex 0.0287989253372785 1441 41 8 0.195121951219512 0.00555170020818876
GO:CC GO:0009986 cell surface 0.0312359892242223 899 30 5 0.166666666666667 0.00556173526140156
GO:CC GO:0001726 ruffle 0.0366216386719195 179 55 3 0.0545454545454545 0.0167597765363128
GO:CC GO:0005925 focal adhesion 0.0452629995224477 420 26 3 0.115384615384615 0.00714285714285714
GO:CC GO:0030055 cell-substrate junction 0.0468664084338274 427 26 3 0.115384615384615 0.00702576112412178
GO:CC GO:0140535 intracellular protein-containing complex 0.0474393686935978 767 15 3 0.2 0.00391134289439374
GO:MF GO:0009055 electron transfer activity 6.37098470221872e-09 148 41 9 0.219512195121951 0.0608108108108108
GO:MF GO:0016675 oxidoreductase activity, acting on a heme group of donors 1.35786565671082e-06 28 22 4 0.181818181818182 0.142857142857143
GO:MF GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 1.35786565671082e-06 27 22 4 0.181818181818182 0.148148148148148
GO:MF GO:0004129 cytochrome-c oxidase activity 1.35786565671082e-06 27 22 4 0.181818181818182 0.148148148148148
GO:MF GO:0015002 heme-copper terminal oxidase activity 1.35786565671082e-06 27 22 4 0.181818181818182 0.148148148148148
GO:MF GO:0015078 proton transmembrane transporter activity 1.16188309367442e-05 125 22 5 0.227272727272727 0.04
GO:MF GO:0016491 oxidoreductase activity 1.87708718838226e-05 771 41 11 0.268292682926829 0.0142671854734112
GO:MF GO:0003735 structural constituent of ribosome 0.00202805906795133 171 26 4 0.153846153846154 0.0233918128654971
GO:MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 0.00216182882529326 46 39 3 0.0769230769230769 0.0652173913043478
GO:MF GO:0003954 NADH dehydrogenase activity 0.00216182882529326 46 39 3 0.0769230769230769 0.0652173913043478
GO:MF GO:0050136 NADH dehydrogenase (quinone) activity 0.00216182882529326 46 39 3 0.0769230769230769 0.0652173913043478
GO:MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity 0.00226414815996862 49 39 3 0.0769230769230769 0.0612244897959184
GO:MF GO:0046914 transition metal ion binding 0.00248049233414776 1111 6 4 0.666666666666667 0.0036003600360036
GO:MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.00330419276233329 61 39 3 0.0769230769230769 0.0491803278688525
GO:MF GO:0005198 structural molecule activity 0.00360534768538595 698 26 6 0.230769230769231 0.00859598853868195
GO:MF GO:0022890 inorganic cation transmembrane transporter activity 0.00558730700306621 591 22 5 0.227272727272727 0.00846023688663283
GO:MF GO:0015075 ion transmembrane transporter activity 0.00662574707824312 956 22 6 0.272727272727273 0.00627615062761506
GO:MF GO:0008324 cation transmembrane transporter activity 0.00730285901398771 639 22 5 0.227272727272727 0.00782472613458529
GO:MF GO:0022857 transmembrane transporter activity 0.00972474307769181 1075 22 6 0.272727272727273 0.00558139534883721
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.0108562789595198 107 39 3 0.0769230769230769 0.0280373831775701
GO:MF GO:0008092 cytoskeletal protein binding 0.0137062292858083 996 11 4 0.363636363636364 0.00401606425702811
GO:MF GO:0005215 transporter activity 0.0137062292858083 1185 22 6 0.272727272727273 0.00506329113924051
GO:MF GO:0015318 inorganic molecular entity transmembrane transporter activity 0.0155679782102717 831 22 5 0.227272727272727 0.00601684717208183
GO:MF GO:0003723 RNA binding 0.0216506692671462 1943 26 8 0.307692307692308 0.00411734431291817
GO:MF GO:0004252 serine-type endopeptidase activity 0.0218256175601979 171 35 3 0.0857142857142857 0.0175438596491228
GO:MF GO:0008236 serine-type peptidase activity 0.0261971278738716 189 35 3 0.0857142857142857 0.0158730158730159
GO:MF GO:0017171 serine hydrolase activity 0.0266300191771401 193 35 3 0.0857142857142857 0.0155440414507772
GO:MF GO:0042802 identical protein binding 0.0266300191771401 2067 26 8 0.307692307692308 0.003870343492985
HP HP:0001427 Mitochondrial inheritance 8.26475472262162e-05 18 32 5 0.15625 0.277777777777778
HP HP:0012766 Widened cerebral subarachnoid space 8.26475472262162e-05 8 32 4 0.125 0.5
HP HP:0005157 Concentric hypertrophic cardiomyopathy 9.81889728416181e-05 10 32 4 0.125 0.4
HP HP:0007327 Mixed demyelinating and axonal polyneuropathy 9.81889728416181e-05 9 32 4 0.125 0.444444444444444
HP HP:0004309 Ventricular preexcitation 9.81889728416181e-05 23 32 5 0.15625 0.217391304347826
HP HP:0025268 Stuttering 0.000163671215468353 12 32 4 0.125 0.333333333333333
HP HP:0000576 Centrocecal scotoma 0.000163671215468353 12 32 4 0.125 0.333333333333333
HP HP:0007067 Distal peripheral sensory neuropathy 0.000205829277375419 13 32 4 0.125 0.307692307692308
HP HP:0001345 Psychotic mentation 0.000254864100336475 14 32 4 0.125 0.285714285714286
HP HP:0100027 Recurrent pancreatitis 0.000259354964065669 15 32 4 0.125 0.266666666666667
HP HP:0002572 Episodic vomiting 0.000259354964065669 32 32 5 0.15625 0.15625
HP HP:0002401 Stroke-like episode 0.000259354964065669 15 32 4 0.125 0.266666666666667
HP HP:0007159 Fluctuations in consciousness 0.00038374645998962 17 32 4 0.125 0.235294117647059
HP HP:0012707 Elevated brain lactate level by MRS 0.00038374645998962 17 32 4 0.125 0.235294117647059
HP HP:0003200 Ragged-red muscle fibers 0.000407517749635515 40 32 5 0.15625 0.125
HP HP:0200125 Mitochondrial respiratory chain defects 0.000407517749635515 18 32 4 0.125 0.222222222222222
HP HP:0012429 Aplasia/Hypoplasia of the cerebral white matter 0.000407517749635515 19 32 4 0.125 0.210526315789474
HP HP:0007763 Retinal telangiectasia 0.000407517749635515 19 32 4 0.125 0.210526315789474
HP HP:0030895 Abnormal gastrointestinal motility 0.000407517749635515 71 32 6 0.1875 0.0845070422535211
HP HP:0001716 Wolff-Parkinson-White syndrome 0.000407517749635515 19 32 4 0.125 0.210526315789474
HP HP:0002579 Gastrointestinal dysmotility 0.000407517749635515 71 32 6 0.1875 0.0845070422535211
HP HP:0003800 Muscle abnormality related to mitochondrial dysfunction 0.000407517749635515 69 32 6 0.1875 0.0869565217391304
HP HP:0025045 Abnormal brain lactate level by MRS 0.000407517749635515 18 32 4 0.125 0.222222222222222
HP HP:0002922 Increased CSF protein 0.00062598770150956 45 32 5 0.15625 0.111111111111111
HP HP:0004389 Intestinal pseudo-obstruction 0.000746051939093698 23 32 4 0.125 0.173913043478261
HP HP:0025456 Abnormal CSF protein level 0.000746051939093698 47 32 5 0.15625 0.106382978723404
HP HP:0001045 Vitiligo 0.00101609407097356 25 32 4 0.125 0.16
HP HP:0000590 Progressive external ophthalmoplegia 0.00111244130458586 26 32 4 0.125 0.153846153846154
HP HP:0002331 Recurrent paroxysmal headache 0.00111244130458586 26 32 4 0.125 0.153846153846154
HP HP:0030085 Abnormal CSF lactate level 0.0012331077691492 91 32 6 0.1875 0.0659340659340659
HP HP:0002490 Increased CSF lactate 0.0012331077691492 91 32 6 0.1875 0.0659340659340659
HP HP:0003737 Mitochondrial myopathy 0.0012331077691492 54 32 5 0.15625 0.0925925925925926
HP HP:0001112 Leber optic atrophy 0.00130984336650657 10 32 3 0.09375 0.3
HP HP:0010794 Impaired visuospatial constructive cognition 0.00148496962043831 29 32 4 0.125 0.137931034482759
HP HP:0007768 Central retinal vessel vascular tortuosity 0.00164295224083003 11 32 3 0.09375 0.272727272727273
HP HP:0000631 Retinal arterial tortuosity 0.00164295224083003 11 32 3 0.09375 0.272727272727273
HP HP:0000622 Blurred vision 0.0019308608184073 32 32 4 0.125 0.125
HP HP:0012705 Abnormal metabolic brain imaging by MRS 0.0019308608184073 32 32 4 0.125 0.125
HP HP:0007924 Slow decrease in visual acuity 0.0019308608184073 32 32 4 0.125 0.125
HP HP:0007302 Bipolar affective disorder 0.00240371933419868 34 32 4 0.125 0.117647058823529
HP HP:0002135 Basal ganglia calcification 0.00257174676742621 35 32 4 0.125 0.114285714285714
HP HP:0100754 Mania 0.00257174676742621 35 32 4 0.125 0.114285714285714
HP HP:0025454 Abnormal CSF metabolite level 0.00268028082009147 110 32 6 0.1875 0.0545454545454545
HP HP:0000829 Hypoparathyroidism 0.00306563282925154 37 32 4 0.125 0.108108108108108
HP HP:0002381 Aphasia 0.00312077118898749 71 32 5 0.15625 0.0704225352112676
HP HP:0008316 Abnormal mitochondria in muscle tissue 0.00319480129575647 38 32 4 0.125 0.105263157894737
HP HP:0007141 Sensorimotor neuropathy 0.00319480129575647 72 32 5 0.15625 0.0694444444444444
HP HP:0012841 Retinal vascular tortuosity 0.00422360601914098 41 32 4 0.125 0.0975609756097561
HP HP:0000751 Personality changes 0.00499176412222929 43 32 4 0.125 0.0930232558139535
HP HP:0000603 Central scotoma 0.00562243464610698 45 32 4 0.125 0.0888888888888889
HP HP:0000097 Focal segmental glomerulosclerosis 0.00562243464610698 45 32 4 0.125 0.0888888888888889
HP HP:0100651 Type I diabetes mellitus 0.00562243464610698 45 32 4 0.125 0.0888888888888889
HP HP:0002134 Abnormality of the basal ganglia 0.00652647558527895 201 22 6 0.272727272727273 0.0298507462686567
HP HP:0000114 Proximal tubulopathy 0.00696539186712827 48 32 4 0.125 0.0833333333333333
HP HP:0005116 Arterial tortuosity 0.00711251328602531 20 32 3 0.09375 0.15
HP HP:0003287 Abnormality of mitochondrial metabolism 0.00745678010684167 139 32 6 0.1875 0.0431654676258993
HP HP:0003477 Peripheral axonal neuropathy 0.00791402123273559 141 32 6 0.1875 0.0425531914893617
HP HP:0002174 Postural tremor 0.00884414979360283 52 32 4 0.125 0.0769230769230769
HP HP:0004948 Vascular tortuosity 0.00887032094280706 22 32 3 0.09375 0.136363636363636
HP HP:0000544 External ophthalmoplegia 0.0104788044509651 55 32 4 0.125 0.0727272727272727
HP HP:0000112 Nephropathy 0.0104788044509651 98 32 5 0.15625 0.0510204081632653
HP HP:0000580 Pigmentary retinopathy 0.010511815255201 151 32 6 0.1875 0.0397350993377483
HP HP:0000408 Progressive sensorineural hearing impairment 0.011807196555757 36 22 3 0.136363636363636 0.0833333333333333
HP HP:0000709 Psychosis 0.0131213887722931 104 32 5 0.15625 0.0480769230769231
HP HP:0004308 Ventricular arrhythmia 0.0140940344370212 106 32 5 0.15625 0.0471698113207547
HP HP:0012103 Abnormality of the mitochondrion 0.0148168491688727 163 32 6 0.1875 0.0368098159509202
HP HP:0000726 Dementia 0.0150737153794003 164 32 6 0.1875 0.0365853658536585
HP HP:0011767 Abnormality of the parathyroid physiology 0.01548215448984 63 32 4 0.125 0.0634920634920635
HP HP:0012377 Hemianopia 0.0156152510595436 41 22 3 0.136363636363636 0.0731707317073171
HP HP:0010783 Erythema 0.0172510060871551 113 32 5 0.15625 0.0442477876106195
HP HP:0002151 Increased serum lactate 0.0180062137148899 172 32 6 0.1875 0.0348837209302326
HP HP:0000764 Peripheral axonal degeneration 0.0181776778444467 173 32 6 0.1875 0.0346820809248555
HP HP:0001730 Progressive hearing impairment 0.0181776778444467 44 22 3 0.136363636363636 0.0681818181818182
HP HP:0031546 Cardiac conduction abnormality 0.0239012674232695 123 32 5 0.15625 0.040650406504065
HP HP:0000575 Scotoma 0.0257000282113772 74 32 4 0.125 0.0540540540540541
HP HP:0000096 Glomerular sclerosis 0.0263200405220636 75 32 4 0.125 0.0533333333333333
HP HP:0000828 Abnormality of the parathyroid gland 0.0263200405220636 75 32 4 0.125 0.0533333333333333
HP HP:0001733 Pancreatitis 0.0272939454333186 76 32 4 0.125 0.0526315789473684
HP HP:0003546 Exercise intolerance 0.0350860004714538 82 32 4 0.125 0.0487804878048781
HP HP:0004303 Abnormal muscle fiber morphology 0.0350860004714538 205 22 5 0.227272727272727 0.024390243902439
HP HP:0001297 Stroke 0.0350860004714538 138 32 5 0.15625 0.036231884057971
HP HP:0001271 Polyneuropathy 0.0354676272364225 58 46 4 0.0869565217391304 0.0689655172413793
HP HP:0007183 Focal T2 hyperintense basal ganglia lesion 0.0354676272364225 40 32 3 0.09375 0.075
HP HP:0001269 Hemiparesis 0.0365552360456567 85 32 4 0.125 0.0470588235294118
HP HP:0001268 Mental deterioration 0.0382593412263258 311 22 6 0.272727272727273 0.0192926045016077
HP HP:0008619 Bilateral sensorineural hearing impairment 0.0397680670617968 62 22 3 0.136363636363636 0.0483870967741935
HP HP:0012704 Widened subarachnoid space 0.0397680670617968 88 32 4 0.125 0.0454545454545455
HP HP:0001644 Dilated cardiomyopathy 0.0397680670617968 145 32 5 0.15625 0.0344827586206897
HP HP:0001336 Myoclonus 0.0454660534076879 326 22 6 0.272727272727273 0.0184049079754601
HP HP:0410263 Brain imaging abnormality 0.0491546808599125 95 32 4 0.125 0.0421052631578947
HPA HPA:0040083 bone marrow; hematopoietic cells[High] 0.00151136168329111 1376 8 7 0.875 0.00508720930232558
KEGG KEGG:00190 Oxidative phosphorylation 7.3837871044936e-08 133 41 10 0.24390243902439 0.075187969924812
KEGG KEGG:04714 Thermogenesis 6.27991277006919e-07 232 41 11 0.268292682926829 0.0474137931034483
KEGG KEGG:05415 Diabetic cardiomyopathy 1.48431740202333e-06 203 41 10 0.24390243902439 0.0492610837438424
KEGG KEGG:05012 Parkinson disease 7.72795018269691e-05 249 41 9 0.219512195121951 0.036144578313253
KEGG KEGG:05020 Prion disease 0.000131259471548749 273 41 9 0.219512195121951 0.032967032967033
KEGG KEGG:04932 Non-alcoholic fatty liver disease 0.000131838007190816 150 41 7 0.170731707317073 0.0466666666666667
KEGG KEGG:05014 Amyotrophic lateral sclerosis 0.000131838007190816 363 41 10 0.24390243902439 0.0275482093663912
KEGG KEGG:05016 Huntington disease 0.00020583633914507 306 41 9 0.219512195121951 0.0294117647058824
KEGG KEGG:04260 Cardiac muscle contraction 0.000209374008023535 87 53 6 0.113207547169811 0.0689655172413793
KEGG KEGG:05010 Alzheimer disease 0.000717899985418895 369 41 9 0.219512195121951 0.024390243902439
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 0.00436609942790035 475 41 9 0.219512195121951 0.0189473684210526
KEGG KEGG:03010 Ribosome 0.00947929366083054 153 26 4 0.153846153846154 0.0261437908496732
KEGG KEGG:05171 Coronavirus disease - COVID-19 0.0341506504206572 231 26 4 0.153846153846154 0.0173160173160173
MIRNA MIRNA:hsa-miR-744-5p hsa-miR-744-5p 0.00323329713371155 435 34 8 0.235294117647059 0.0183908045977011
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1.9435062033489e-07 124 41 9 0.219512195121951 0.0725806451612903
REAC REAC:R-HSA-611105 Respiratory electron transport 4.31480455475451e-07 100 41 8 0.195121951219512 0.08
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 1.2983683540589e-06 174 41 9 0.219512195121951 0.0517241379310345
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 1.51944973136751e-05 113 26 6 0.230769230769231 0.0530973451327434
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.000202559994789952 474 30 9 0.3 0.0189873417721519
REAC REAC:R-HSA-5628897 TP53 Regulates Metabolic Genes 0.000926230396633219 83 22 4 0.181818181818182 0.0481927710843374
REAC REAC:R-HSA-72766 Translation 0.00150551972133068 292 26 6 0.230769230769231 0.0205479452054795
REAC REAC:R-HSA-192823 Viral mRNA Translation 0.00150551972133068 90 26 4 0.153846153846154 0.0444444444444444
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 0.00150551972133068 94 26 4 0.153846153846154 0.0425531914893617
REAC REAC:R-HSA-156902 Peptide chain elongation 0.00150551972133068 90 26 4 0.153846153846154 0.0444444444444444
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 0.00150551972133068 94 26 4 0.153846153846154 0.0425531914893617
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 0.00150551972133068 94 26 4 0.153846153846154 0.0425531914893617
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.00150881929966752 96 26 4 0.153846153846154 0.0416666666666667
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.00165608314092865 102 26 4 0.153846153846154 0.0392156862745098
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 0.00165608314092865 102 26 4 0.153846153846154 0.0392156862745098
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 0.00201255425024939 117 26 4 0.153846153846154 0.0341880341880342
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.00201255425024939 113 26 4 0.153846153846154 0.0353982300884956
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 0.00201255425024939 116 26 4 0.153846153846154 0.0344827586206897
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 0.00201255425024939 116 26 4 0.153846153846154 0.0344827586206897
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.00201255425024939 112 26 4 0.153846153846154 0.0357142857142857
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 0.00202585908431869 120 26 4 0.153846153846154 0.0333333333333333
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 0.00202585908431869 120 26 4 0.153846153846154 0.0333333333333333
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 0.00276564863305964 133 26 4 0.153846153846154 0.0300751879699248
REAC REAC:R-HSA-432722 Golgi Associated Vesicle Biogenesis 0.00370759031026828 54 29 3 0.103448275862069 0.0555555555555556
REAC REAC:R-HSA-168255 Influenza Infection 0.00410424160148278 152 26 4 0.153846153846154 0.0263157894736842
REAC REAC:R-HSA-168249 Innate Immune System 0.00417974495215933 1073 30 10 0.333333333333333 0.00931966449207828
REAC REAC:R-HSA-9711097 Cellular response to starvation 0.00432927878240643 157 26 4 0.153846153846154 0.0254777070063694
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.00528926357605573 171 26 4 0.153846153846154 0.0233918128654971
REAC REAC:R-HSA-199992 trans-Golgi Network Vesicle Budding 0.00646749503464844 72 29 3 0.103448275862069 0.0416666666666667
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 0.00646749503464844 183 26 4 0.153846153846154 0.0218579234972678
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 0.00760233258533098 193 26 4 0.153846153846154 0.0207253886010363
REAC REAC:R-HSA-72312 rRNA processing 0.00892332756508628 203 26 4 0.153846153846154 0.0197044334975369
REAC REAC:R-HSA-5663205 Infectious disease 0.0105264653460765 815 18 6 0.333333333333333 0.00736196319018405
REAC REAC:R-HSA-422475 Axon guidance 0.0105692993670253 549 26 6 0.230769230769231 0.0109289617486339
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 0.0105692993670253 217 26 4 0.153846153846154 0.0184331797235023
REAC REAC:R-HSA-9675108 Nervous system development 0.0120686591560361 574 26 6 0.230769230769231 0.0104529616724739
REAC REAC:R-HSA-3700989 Transcriptional Regulation by TP53 0.0284601443555965 360 22 4 0.181818181818182 0.0111111111111111
REAC REAC:R-HSA-392499 Metabolism of proteins 0.0427974462304668 1961 18 8 0.444444444444444 0.00407955124936257
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 0.0447004792352752 368 26 4 0.153846153846154 0.0108695652173913
TF TF:M08320_1 Factor: GCMa:HOXB13; motif: RTGCGGGTMATAAAN; match class: 1 0.000113403323126383 22 27 4 0.148148148148148 0.181818181818182
TF TF:M08320 Factor: GCMa:HOXB13; motif: RTGCGGGTMATAAAN 0.00140102214683672 837 32 10 0.3125 0.01194743130227
TF TF:M08331 Factor: GCMb:FOXI1; motif: RTAAATANGGGNN 0.0116012017369378 45 21 3 0.142857142857143 0.0666666666666667
TF TF:M08319 Factor: GCMa:HOXA13; motif: RTGCGGGTAATAAA 0.0179961405858942 455 27 6 0.222222222222222 0.0131868131868132
TF TF:M11594 Factor: GCMa; motif: ATGNGGGYR 0.032621047827248 651 22 6 0.272727272727273 0.00921658986175115
TF TF:M09953_1 Factor: HOXB13; motif: TTTTATNGSN; match class: 1 0.032621047827248 79 21 3 0.142857142857143 0.0379746835443038
TF TF:M01877 Factor: GATA-2; motif: GATAANN 0.032621047827248 1709 10 6 0.6 0.00351082504388531
TF TF:M12285_1 Factor: ZNF647; motif: NTAGGCCTAN; match class: 1 0.032621047827248 429 21 5 0.238095238095238 0.0116550116550117
TF TF:M12296 Factor: ZNF282; motif: NTTCCCAYNACMCK 0.0460608672292314 343 29 5 0.172413793103448 0.0145772594752187
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 8.70714009156415e-09 105 41 10 0.24390243902439 0.0952380952380952
WP WP:WP4922 Mitochondrial CIV Assembly 4.68240824084933e-06 35 28 5 0.178571428571429 0.142857142857143
WP WP:WP4396 Nonalcoholic fatty liver disease 0.000318593229081508 159 41 7 0.170731707317073 0.0440251572327044
WP WP:WP623 Oxidative phosphorylation 0.00296188859643808 62 39 4 0.102564102564103 0.0645161290322581
WP WP:WP477 Cytoplasmic Ribosomal Proteins 0.00296188859643808 90 26 4 0.153846153846154 0.0444444444444444
WP WP:WP98 Prostaglandin Synthesis and Regulation 0.016375812450784 45 46 3 0.0652173913043478 0.0666666666666667

pMA05 transcription factor target enrichment of top program genes

TF enrichment of pMA05
TFs corrosponding to activation of pMA05. (Left) pearson correlation of TF expression and gene expression program activatity in Mast cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.