pEpiTp02 program activity among Epithelial cells

Activation of pEpiTp02
pEpiTp02 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp02 by different cell subtypes
pEpiTp02 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp02 top program genes

Top genes of pEpiTp02 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp02 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp02
pEpiTp02 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0010273 detoxification of copper ion 3.1568094140833e-17 14 12 7 0.583333333333333 0.5
GO:BP GO:1990169 stress response to copper ion 3.1568094140833e-17 14 12 7 0.583333333333333 0.5
GO:BP GO:0061687 detoxification of inorganic compound 5.25880640244894e-17 16 12 7 0.583333333333333 0.4375
GO:BP GO:0097501 stress response to metal ion 5.25880640244894e-17 16 12 7 0.583333333333333 0.4375
GO:BP GO:0071294 cellular response to zinc ion 9.00037366558798e-16 23 12 7 0.583333333333333 0.304347826086957
GO:BP GO:0071280 cellular response to copper ion 2.71420461256997e-15 27 12 7 0.583333333333333 0.259259259259259
GO:BP GO:0006882 cellular zinc ion homeostasis 1.74935323983579e-14 37 6 6 1 0.162162162162162
GO:BP GO:0071276 cellular response to cadmium ion 1.74935323983579e-14 37 6 6 1 0.162162162162162
GO:BP GO:0055069 zinc ion homeostasis 2.18227399110827e-14 39 6 6 1 0.153846153846154
GO:BP GO:0046688 response to copper ion 3.15787883419198e-14 42 6 6 1 0.142857142857143
GO:BP GO:0010043 response to zinc ion 1.58648347961591e-13 55 6 6 1 0.109090909090909
GO:BP GO:0046686 response to cadmium ion 4.14359981643621e-13 65 6 6 1 0.0923076923076923
GO:BP GO:0046916 cellular transition metal ion homeostasis 1.37400771027209e-11 116 6 6 1 0.0517241379310345
GO:BP GO:0098754 detoxification 3.08644888774922e-11 134 6 6 1 0.0447761194029851
GO:BP GO:0055076 transition metal ion homeostasis 3.44817982838027e-11 138 6 6 1 0.0434782608695652
GO:BP GO:0009636 response to toxic substance 8.14722719748033e-11 243 12 8 0.666666666666667 0.0329218106995885
GO:BP GO:0071248 cellular response to metal ion 2.27694705230736e-10 192 6 6 1 0.03125
GO:BP GO:0071241 cellular response to inorganic substance 4.91648960552588e-10 220 6 6 1 0.0272727272727273
GO:BP GO:0045926 negative regulation of growth 1.14026943830339e-09 255 6 6 1 0.0235294117647059
GO:BP GO:0010038 response to metal ion 1.04669311808535e-08 371 6 6 1 0.0161725067385445
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 5.82123774457587e-08 497 6 6 1 0.0120724346076459
GO:BP GO:0072507 divalent inorganic cation homeostasis 6.96719540786017e-08 516 6 6 1 0.0116279069767442
GO:BP GO:0010035 response to inorganic substance 1.27987015503173e-07 575 6 6 1 0.0104347826086957
GO:BP GO:0006875 cellular metal ion homeostasis 1.47689516253624e-07 593 6 6 1 0.0101180438448567
GO:BP GO:0055065 metal ion homeostasis 2.87921232789104e-07 667 6 6 1 0.00899550224887556
GO:BP GO:0030003 cellular cation homeostasis 2.92188614203838e-07 673 6 6 1 0.00891530460624071
GO:BP GO:0040008 regulation of growth 3.02120009350657e-07 681 6 6 1 0.00881057268722467
GO:BP GO:0006873 cellular ion homeostasis 3.0713334465552e-07 687 6 6 1 0.00873362445414847
GO:BP GO:0055080 cation homeostasis 5.02938380881262e-07 750 6 6 1 0.008
GO:BP GO:0098771 inorganic ion homeostasis 5.30710948415064e-07 761 6 6 1 0.00788436268068331
GO:BP GO:0050801 ion homeostasis 7.36678701790594e-07 808 6 6 1 0.00742574257425743
GO:BP GO:0055082 cellular chemical homeostasis 9.08061817435295e-07 841 6 6 1 0.00713436385255648
GO:BP GO:0040007 growth 2.03961296181629e-06 967 6 6 1 0.0062047569803516
GO:BP GO:0019725 cellular homeostasis 2.15841271259742e-06 981 6 6 1 0.00611620795107034
GO:BP GO:0048878 chemical homeostasis 8.13180846860384e-06 1229 6 6 1 0.0048820179007323
GO:BP GO:0042592 homeostatic process 0.000131972716569604 1981 6 6 1 0.00302877334679455
GO:BP GO:0070887 cellular response to chemical stimulus 0.00325664148530672 3393 6 6 1 0.0017683465959328
GO:BP GO:0006950 response to stress 0.00414474069844806 4170 9 8 0.888888888888889 0.00191846522781775
GO:BP GO:0065008 regulation of biological quality 0.0100976903829357 4131 6 6 1 0.00145243282498184
GO:BP GO:0042221 response to chemical 0.011351599700977 4781 9 8 0.888888888888889 0.00167329010667224
GO:BP GO:0048519 negative regulation of biological process 0.0161423513480018 5757 10 9 0.9 0.00156331422615946
GO:BP GO:0070125 mitochondrial translational elongation 0.0174453686212765 87 118 5 0.0423728813559322 0.0574712643678161
GO:BP GO:0070126 mitochondrial translational termination 0.0179920854493138 88 118 5 0.0423728813559322 0.0568181818181818
GO:BP GO:0006487 protein N-linked glycosylation 0.0184175166449036 76 31 3 0.0967741935483871 0.0394736842105263
GO:BP GO:0050434 positive regulation of viral transcription 0.0343758478438653 24 124 3 0.0241935483870968 0.125
GO:BP GO:0006415 translational termination 0.03499936271957 104 118 5 0.0423728813559322 0.0480769230769231
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.0469635647663574 1853 105 22 0.20952380952381 0.0118726389638424
GO:CC GO:0005737 cytoplasm 0.000256393697229724 11911 43 41 0.953488372093023 0.00344219628914449
GO:CC GO:1990904 ribonucleoprotein complex 0.000355341558126512 688 62 12 0.193548387096774 0.0174418604651163
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00717905282648967 11296 105 81 0.771428571428571 0.00717067988668555
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.00717905282648967 124 70 5 0.0714285714285714 0.0403225806451613
GO:CC GO:0005759 mitochondrial matrix 0.00717905282648967 479 134 12 0.0895522388059701 0.0250521920668058
GO:CC GO:0043227 membrane-bounded organelle 0.00717905282648967 12858 71 62 0.873239436619718 0.00482190076217141
GO:CC GO:0005829 cytosol 0.00806289389901995 5303 70 34 0.485714285714286 0.00641146520837262
GO:CC GO:0005743 mitochondrial inner membrane 0.0103126020645754 503 118 11 0.0932203389830508 0.0218687872763419
GO:CC GO:0031967 organelle envelope 0.0103126020645754 1237 103 17 0.16504854368932 0.0137429264349232
GO:CC GO:0031975 envelope 0.0103126020645754 1237 103 17 0.16504854368932 0.0137429264349232
GO:CC GO:0043229 intracellular organelle 0.0103126020645754 12491 71 60 0.845070422535211 0.00480345849011288
GO:CC GO:0031090 organelle membrane 0.0109206340859196 3612 118 38 0.322033898305085 0.0105204872646733
GO:CC GO:0043226 organelle 0.0109206340859196 14008 48 45 0.9375 0.00321245002855511
GO:CC GO:0101002 ficolin-1-rich granule 0.0130547205411047 184 70 5 0.0714285714285714 0.0271739130434783
GO:CC GO:0005739 mitochondrion 0.0130547205411047 1673 103 20 0.194174757281553 0.0119545726240287
GO:CC GO:0005622 intracellular anatomical structure 0.0135547179982976 14790 71 66 0.929577464788732 0.00446247464503043
GO:CC GO:0031966 mitochondrial membrane 0.0140179907026501 746 103 12 0.116504854368932 0.0160857908847185
GO:CC GO:0019866 organelle inner membrane 0.0145405472433229 564 118 11 0.0932203389830508 0.0195035460992908
GO:CC GO:0044391 ribosomal subunit 0.0203276068096671 190 118 6 0.0508474576271186 0.0315789473684211
GO:CC GO:0005740 mitochondrial envelope 0.0204822532014045 797 103 12 0.116504854368932 0.0150564617314931
GO:CC GO:0005761 mitochondrial ribosome 0.032636843472892 88 118 4 0.0338983050847458 0.0454545454545455
GO:CC GO:0000313 organellar ribosome 0.032636843472892 88 118 4 0.0338983050847458 0.0454545454545455
GO:CC GO:0005634 nucleus 0.0384529925141675 7592 12 10 0.833333333333333 0.00131717597471022
GO:CC GO:0005684 U2-type spliceosomal complex 0.0401800237464318 93 122 4 0.0327868852459016 0.043010752688172
GO:CC GO:0035770 ribonucleoprotein granule 0.0412601921579397 248 47 4 0.0851063829787234 0.0161290322580645
GO:CC GO:0071005 U2-type precatalytic spliceosome 0.0454311681233003 50 122 3 0.0245901639344262 0.06
GO:CC GO:0005840 ribosome 0.0454311681233003 245 118 6 0.0508474576271186 0.0244897959183673
GO:CC GO:0071011 precatalytic spliceosome 0.046546353848258 52 122 3 0.0245901639344262 0.0576923076923077
GO:MF GO:0008270 zinc ion binding 3.62179461933132e-06 833 6 6 1 0.00720288115246098
GO:MF GO:0046914 transition metal ion binding 1.02393550975172e-05 1111 6 6 1 0.0054005400540054
GO:MF GO:0043169 cation binding 0.0186581320401847 4351 6 6 1 0.00137899333486555
GO:MF GO:0046872 metal ion binding 0.0186581320401847 4260 6 6 1 0.00140845070422535
GO:MF GO:0046915 transition metal ion transmembrane transporter activity 0.0339032164589951 39 98 3 0.0306122448979592 0.0769230769230769
GO:MF GO:0043167 ion binding 0.0339032164589951 6057 6 6 1 0.000990589400693413
GO:MF GO:0003723 RNA binding 0.0339032164589951 1943 62 16 0.258064516129032 0.00823468862583634
KEGG KEGG:04978 Mineral absorption 1.57344592755359e-11 59 6 6 1 0.101694915254237
KEGG KEGG:03060 Protein export 0.044620248246909 23 62 3 0.0483870967741935 0.130434782608696
MIRNA MIRNA:hsa-miR-3613-5p hsa-miR-3613-5p 0.00141780863731339 47 7 3 0.428571428571429 0.0638297872340425
REAC REAC:R-HSA-5661231 Metallothioneins bind metals 3.24886800866918e-17 11 12 7 0.583333333333333 0.636363636363636
REAC REAC:R-HSA-5660526 Response to metal ions 1.68730687170141e-16 14 12 7 0.583333333333333 0.5
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 2.60517393127423e-06 560 6 6 1 0.0107142857142857
TF TF:M00650_1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 1.10332521474202e-11 24 5 5 1 0.208333333333333
TF TF:M00650 Factor: MTF-1; motif: TBTGCACHCGGCCC 2.15946320549526e-07 816 12 9 0.75 0.0110294117647059
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 4.63686761706443e-05 13929 130 118 0.907692307692308 0.00847153420920382
TF TF:M02070 Factor: TEL1; motif: CNCGGAANNN 9.59293851417658e-05 10837 135 104 0.77037037037037 0.00959675186859832
TF TF:M10163 Factor: ZNF708; motif: GNNNAANAARNAGGYACAGC 9.59293851417658e-05 219 5 4 0.8 0.0182648401826484
TF TF:M01119_1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 1 9.59345810423725e-05 542 6 5 0.833333333333333 0.00922509225092251
TF TF:M08890 Factor: MYB; motif: NNAACTGN 9.59345810423725e-05 1355 6 6 1 0.0044280442804428
TF TF:M04619_1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 0.000111067772185711 50 19 4 0.210526315789474 0.08
TF TF:M08266_1 Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 0.00018732861417168 8979 130 88 0.676923076923077 0.009800645951665
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.000218993176586852 13184 99 88 0.888888888888889 0.0066747572815534
TF TF:M11601_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.000426616025591292 11053 120 93 0.775 0.00841400524744413
TF TF:M07341 Factor: TORC2; motif: TGGGCTKKD 0.000465960513344967 4887 10 10 1 0.00204624514016779
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.000594153203404674 16194 130 125 0.961538461538462 0.00771890823761887
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.000934805014280152 14473 113 103 0.911504424778761 0.00711670006218476
TF TF:M00716 Factor: ZF5; motif: GSGCGCGR 0.00104960459908127 16103 78 77 0.987179487179487 0.00478171769235546
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.00105899682605747 14873 73 70 0.958904109589041 0.00470651516170241
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.00105899682605747 11063 48 42 0.875 0.00379643857904727
TF TF:M11018_1 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 0.00105899682605747 15920 73 72 0.986301369863014 0.00452261306532663
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.00108237593094644 14997 118 109 0.923728813559322 0.00726812029072481
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.00123169396900191 14106 73 68 0.931506849315068 0.00482064369771728
TF TF:M04619 Factor: MTF-1; motif: CCGNGTGCAV 0.00123169396900191 1167 6 5 0.833333333333333 0.00428449014567267
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.00123169396900191 13611 135 116 0.859259259259259 0.00852251855117185
TF TF:M11529 Factor: E2F-2; motif: GCGCGCGCNCS 0.00133592075367488 16263 113 109 0.964601769911504 0.00670233044333764
TF TF:M08207_1 Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT; match class: 1 0.00133592075367488 15466 130 121 0.930769230769231 0.00782361308677098
TF TF:M10438 Factor: ZF5; motif: GGSGCGCGS 0.00133592075367488 16228 77 76 0.987012987012987 0.00468326349519349
TF TF:M08205 Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT 0.00135959388961763 14429 130 116 0.892307692307692 0.00803936516737127
TF TF:M07341_1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 0.00139534521860771 884 12 6 0.5 0.00678733031674208
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.00177320850151264 10253 128 91 0.7109375 0.00887545108748659
TF TF:M04823_1 Factor: E2F-4; motif: NNTTCCCGCCNN; match class: 1 0.00195341353386005 7850 117 70 0.598290598290598 0.0089171974522293
TF TF:M04218 Factor: MAFK; motif: NTGCTGANTCAGCRN 0.00195341353386005 261 4 3 0.75 0.0114942528735632
TF TF:M08526 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN 0.00198097245692691 16867 134 130 0.970149253731343 0.00770735756210352
TF TF:M11344_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.00198097245692691 268 4 3 0.75 0.0111940298507463
TF TF:M07206_1 Factor: E2F-1; motif: NGGGCGGGARV; match class: 1 0.00212549521765774 10849 134 98 0.73134328358209 0.00903309060742926
TF TF:M11344 Factor: MafF; motif: NTGCTGASTCAGCAN 0.00212549521765774 278 4 3 0.75 0.0107913669064748
TF TF:M11346_1 Factor: MafG; motif: NTGCTGASTCAGCAN; match class: 1 0.00259155044668187 302 4 3 0.75 0.00993377483443709
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.00261733814017002 13173 128 107 0.8359375 0.0081226751689061
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.00262699256862388 11232 128 96 0.75 0.00854700854700855
TF TF:M08225 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG 0.00262699256862388 14039 135 117 0.866666666666667 0.00833392691787164
TF TF:M04903_1 Factor: HNF-4alpha; motif: AGTCCAAR; match class: 1 0.00262699256862388 1534 6 5 0.833333333333333 0.00325945241199478
TF TF:M11601 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.00267078627459538 14823 99 91 0.919191919191919 0.00613910814275113
TF TF:M11346 Factor: MafG; motif: NTGCTGASTCAGCAN 0.00268117865114917 322 4 3 0.75 0.0093167701863354
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.00272342176262596 15268 130 119 0.915384615384615 0.00779407911972753
TF TF:M08225_1 Factor: Elk-1:Pax-5; motif: ACCGGAACYACGCWTSANYG; match class: 1 0.00272342176262596 7993 109 66 0.605504587155963 0.00825722507193795
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.00272342176262596 9162 117 77 0.658119658119658 0.0084042785418031
TF TF:M10085 Factor: RBPJK; motif: NSNSTGGGAAN 0.00277816743528276 3436 12 9 0.75 0.00261932479627474
TF TF:M01240_1 Factor: BEN; motif: CAGCGRNV; match class: 1 0.00298647255239537 13227 46 43 0.934782608695652 0.00325092613593407
TF TF:M11058_1 Factor: Hey1; motif: NGCRCGYGYN; match class: 1 0.00316681443266003 10925 46 39 0.847826086956522 0.00356979405034325
TF TF:M04823 Factor: E2F-4; motif: NNTTCCCGCCNN 0.00343376869239729 12747 117 96 0.82051282051282 0.00753118380795481
TF TF:M08224 Factor: Elk-1:Pax-1; motif: ACCGGAACTACGCWTSANTG 0.0036240418327372 8925 128 81 0.6328125 0.00907563025210084
TF TF:M09892 Factor: E2F-1; motif: NNNNGGCGGGAARN 0.0036240418327372 13528 64 58 0.90625 0.00428740390301597
TF TF:M00774 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN 0.0036240418327372 1818 12 7 0.583333333333333 0.00385038503850385
TF TF:M08568_1 Factor: ER71:E2A; motif: CASSTGNACCGGAWRYN; match class: 1 0.0036240418327372 15133 117 107 0.914529914529915 0.00707064032247406
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.00399631759085573 10023 71 53 0.746478873239437 0.00528783797266288
TF TF:M01240 Factor: BEN; motif: CAGCGRNV 0.00399631759085573 16498 130 124 0.953846153846154 0.00751606255303673
TF TF:M00631 Factor: FXR:RXR-alpha; motif: CAAGGTSAWTAACC 0.00399631759085573 3541 6 6 1 0.00169443659983056
TF TF:M08266 Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG 0.00399631759085573 14377 130 114 0.876923076923077 0.00792933157125965
TF TF:M08226 Factor: Elk-1:Pax-9; motif: ACCGGAACYACGCWYSANTG 0.004397191526504 12039 130 101 0.776923076923077 0.00838940111304926
TF TF:M08289 Factor: Fli-1:Max; motif: NCCGGAAACACGTGN 0.00443261401618766 9971 91 65 0.714285714285714 0.00651890482398957
TF TF:M09990_1 Factor: c-Myb; motif: NNWGRCAGTTRN; match class: 1 0.00486753624171331 3933 14 10 0.714285714285714 0.00254258835494533
TF TF:M07299 Factor: c-Myb; motif: NNNNCMGTTNNN 0.00520407981047221 3767 6 6 1 0.00159277940005309
TF TF:M11365_1 Factor: MafA; motif: NYGCTGASTCAGCRN; match class: 1 0.0053942547147796 467 4 3 0.75 0.00642398286937901
TF TF:M00469 Factor: AP-2alpha; motif: GCCNNNRGS 0.0053942547147796 5147 119 51 0.428571428571429 0.00990868467068195
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.00542837730475672 4320 82 34 0.414634146341463 0.00787037037037037
TF TF:M12067 Factor: ZNF32; motif: NYGTAACNYGAYACC 0.00590418133002382 164 50 5 0.1 0.0304878048780488
TF TF:M05548_1 Factor: PLAGL2; motif: AAGGACC; match class: 1 0.0059786346345161 539 96 11 0.114583333333333 0.0204081632653061
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0059786346345161 13190 134 110 0.82089552238806 0.00833965125094769
TF TF:M11365 Factor: MafA; motif: NYGCTGASTCAGCRN 0.0062499225036452 506 4 3 0.75 0.00592885375494071
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0063648834159766 16384 130 123 0.946153846153846 0.00750732421875
TF TF:M00736 Factor: E2F-1:DP-1; motif: TTTCSCGC 0.00648125963556039 10390 123 86 0.699186991869919 0.0082771896053898
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.00654444689557308 8415 133 79 0.593984962406015 0.00938799762329174
TF TF:M11340_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.00658947497245421 525 4 3 0.75 0.00571428571428571
TF TF:M09813_1 Factor: MYB; motif: NNCAACTGNN; match class: 1 0.00734466107515073 979 6 4 0.666666666666667 0.00408580183861083
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.00734466107515073 14096 128 110 0.859375 0.00780363223609535
TF TF:M11368_1 Factor: MafA; motif: NTGCTGASTCAGCAN; match class: 1 0.00777450683973472 566 4 3 0.75 0.00530035335689046
TF TF:M01859 Factor: AP-2; motif: NNGCCTK 0.00777450683973472 7799 10 10 1 0.00128221566867547
TF TF:M11368 Factor: MafA; motif: NTGCTGASTCAGCAN 0.00777450683973472 570 4 3 0.75 0.00526315789473684
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.00777450683973472 4841 94 40 0.425531914893617 0.00826275562900227
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.00790381014143749 7801 126 71 0.563492063492063 0.00910139725676195
TF TF:M11395 Factor: Erg; motif: NACCGGAWWTCCGGTN 0.00795127492154181 8715 83 54 0.650602409638554 0.00619621342512909
TF TF:M11340 Factor: MafF; motif: NTGCTGASTCAGCAN 0.00795127492154181 580 4 3 0.75 0.00517241379310345
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.00811357599899621 10494 61 47 0.770491803278688 0.00447874976176863
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.00815033170253141 6225 118 57 0.483050847457627 0.0091566265060241
TF TF:M04926 Factor: REST; motif: AAGGTGCT 0.00837604602738066 6325 26 18 0.692307692307692 0.00284584980237154
TF TF:M11401_1 Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1 0.00837604602738066 11801 83 66 0.795180722891566 0.00559274637742564
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.00837604602738066 9362 96 64 0.666666666666667 0.00683614612262337
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 0.00845986578025923 14575 134 117 0.873134328358209 0.00802744425385935
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.00845986578025923 10233 83 60 0.72289156626506 0.0058633831720903
TF TF:M09725_1 Factor: DREF; motif: CTYYCWCTTCCY; match class: 1 0.00860348930908455 2061 61 17 0.278688524590164 0.00824842309558467
TF TF:M00235 Factor: AhR:Arnt; motif: KNNKNNTYGCGTGCMS 0.00877333339543993 3122 50 19 0.38 0.00608584240871236
TF TF:M07084 Factor: E2F-4; motif: NGGCGGGAARN 0.00906168898405879 10834 117 84 0.717948717948718 0.00775336902344471
TF TF:M00144 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM 0.00906168898405879 13205 115 95 0.826086956521739 0.00719424460431655
TF TF:M10012 Factor: Rev-ErbAalpha; motif: NRNNMASTGGGTCANNNNN 0.00931103185096481 1105 6 4 0.666666666666667 0.00361990950226244
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0099869832849616 5919 93 45 0.483870967741935 0.00760263558033452
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.0115469659641943 10640 129 90 0.697674418604651 0.00845864661654135
TF TF:M08878_1 Factor: EGR; motif: CGCCCCCGCNN; match class: 1 0.0119808397094513 3224 126 37 0.293650793650794 0.0114764267990074
TF TF:M00194 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN 0.0121930949303733 2412 12 7 0.583333333333333 0.00290215588723051
TF TF:M11401 Factor: Fli-1; motif: NACCGGATATCCGGTN 0.0122217252271589 11952 83 66 0.795180722891566 0.00552208835341365
TF TF:M02102 Factor: NRF-1; motif: YGCGCMTGCGC 0.0127370348252511 2020 53 15 0.283018867924528 0.00742574257425743
TF TF:M11018 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN 0.0128051376147098 16955 73 72 0.986301369863014 0.00424653494544382
TF TF:M11066 Factor: HES-7; motif: GNCACGYGNN 0.0128051376147098 11507 90 69 0.766666666666667 0.00599635004779699
TF TF:M01273 Factor: SP4; motif: SCCCCGCCCCS 0.0128051376147098 3296 77 26 0.337662337662338 0.00788834951456311
TF TF:M00986 Factor: Churchill; motif: CGGGNN 0.0128051376147098 14197 121 104 0.859504132231405 0.00732549130097908
TF TF:M08207 Factor: E2F-3:TBR2; motif: ANGTGYKANGGCGCSTTNNCRNNT 0.013134037343997 17055 130 125 0.961538461538462 0.00732922896511287
TF TF:M11219 Factor: CREB1; motif: NRTGACGTR 0.013134037343997 873 38 8 0.210526315789474 0.00916380297823597
TF TF:M01783 Factor: SP2; motif: GGGCGGGAC 0.0136110057482745 9148 94 61 0.648936170212766 0.00666812418014867
TF TF:M11739 Factor: COUP-TF1; motif: RRGGTCRNTGACCTN 0.0151684647915618 2698 6 5 0.833333333333333 0.00185322461082283
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.0151684647915618 5198 83 37 0.44578313253012 0.00711812235475183
TF TF:M09746_1 Factor: HNRPUL1; motif: NCNCAGN; match class: 1 0.0153692319883421 7619 22 17 0.772727272727273 0.00223126394539966
TF TF:M04694 Factor: NRF-1; motif: CNCTGCGCATGCGC 0.0153774564837683 1548 133 23 0.172932330827068 0.0148578811369509
TF TF:M00051_1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 1 0.0154734230048998 2797 131 34 0.259541984732824 0.0121558813013944
TF TF:M09641 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN 0.0157519323675598 3222 80 26 0.325 0.00806952203600248
TF TF:M07612 Factor: PSF; motif: KWATCCGN 0.0157519323675598 5581 81 38 0.469135802469136 0.00680881562444006
TF TF:M02065 Factor: ER81; motif: RCCGGAARYN 0.0157519323675598 12550 135 105 0.777777777777778 0.00836653386454183
TF TF:M10110 Factor: TCF17; motif: NTTTANNYCATTTACATTTANTGT 0.0158396621520455 616 5 3 0.6 0.00487012987012987
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0158396621520455 7710 120 66 0.55 0.00856031128404669
TF TF:M00144_1 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 0.0158396621520455 7128 117 61 0.521367521367521 0.00855780022446689
TF TF:M00982 Factor: KROX; motif: CCCGCCCCCRCCCC 0.0158396621520455 7815 65 40 0.615384615384615 0.00511836212412028
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 0.0160583896801811 12351 134 103 0.76865671641791 0.00833940571613635
TF TF:M11603 Factor: TCF-1; motif: ACATCGRGRCGCTGW 0.0167343404105944 16361 99 94 0.94949494949495 0.00574537008740297
TF TF:M12280_1 Factor: MTF-1; motif: NTTTTGCACACGGCNNN; match class: 1 0.0170324095912012 1485 14 6 0.428571428571429 0.00404040404040404
TF TF:M09636 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG 0.017164403813048 16244 113 106 0.938053097345133 0.00652548633341541
TF TF:M11058 Factor: Hey1; motif: NGCRCGYGYN 0.017164403813048 13162 90 75 0.833333333333333 0.00569822215468774
TF TF:M08441 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG 0.0171973387625908 16345 134 125 0.932835820895522 0.00764759865402264
TF TF:M08284 Factor: Fli-1:FIGLA; motif: NCCGGAARCASSTGN 0.0171973387625908 7942 12 11 0.916666666666667 0.00138504155124654
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0171973387625908 10419 128 87 0.6796875 0.0083501295709761
TF TF:M08487 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG 0.0171973387625908 13942 126 106 0.841269841269841 0.00760292640941041
TF TF:M02088 Factor: E2A; motif: NRMCASCTGCNNN 0.0171973387625908 2871 6 5 0.833333333333333 0.0017415534656914
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.0171973387625908 11467 135 98 0.725925925925926 0.00854626319002355
TF TF:M11397 Factor: Erg; motif: NACCGGATATCCGGTN 0.0175123197435118 12005 50 42 0.84 0.00349854227405248
TF TF:M09827 Factor: CREB1; motif: NGRTGAYGWNNN 0.0175123197435118 2676 12 7 0.583333333333333 0.00261584454409567
TF TF:M00235_1 Factor: AhR:Arnt; motif: KNNKNNTYGCGTGCMS; match class: 1 0.0175189472938756 350 35 5 0.142857142857143 0.0142857142857143
TF TF:M01242 Factor: MTF-1; motif: GTGTGCANMACTTTGCGCAC 0.0178006643381756 3931 14 9 0.642857142857143 0.00228949376748919
TF TF:M12354_1 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN; match class: 1 0.0178006643381756 5624 95 43 0.452631578947368 0.00764580369843528
TF TF:M03978 Factor: ETS1; motif: GCCGGAWGTACTTCCGGN 0.0180054107256621 12082 134 101 0.753731343283582 0.00835954312199967
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0180054107256621 10281 128 86 0.671875 0.0083649450442564
TF TF:M04738_1 Factor: ER-alpha; motif: AGGTCANMNTGACC; match class: 1 0.0180868816099089 895 121 15 0.12396694214876 0.0167597765363128
TF TF:M00279_1 Factor: MIF-1; motif: NNGTTGCWWGGYAACNGS; match class: 1 0.018402970105276 5341 6 6 1 0.00112338513387006
TF TF:M10147_1 Factor: ZNF394; motif: NRARWRGAANNNAMWGNAAK; match class: 1 0.0185215514594858 1854 26 9 0.346153846153846 0.00485436893203883
TF TF:M08525 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM 0.0188702046389778 17065 71 70 0.985915492957746 0.00410196308233226
TF TF:M11399_1 Factor: Fli-1; motif: NACCGGAWWTCCGGTY; match class: 1 0.0191228975550739 11513 46 38 0.826086956521739 0.00330061669417181
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0191974039338527 6260 77 39 0.506493506493506 0.00623003194888179
TF TF:M11395_1 Factor: Erg; motif: NACCGGAWWTCCGGTN; match class: 1 0.0194233055248039 7963 89 52 0.584269662921348 0.00653020218510612
TF TF:M03544 Factor: CREB1; motif: NNNNACGTCANN 0.0201459357842911 4101 135 45 0.333333333333333 0.0109729334308705
TF TF:M08700 Factor: Erm:HES-7; motif: NCGGANGNNNNNCRCGYG 0.0201459357842911 2058 125 26 0.208 0.0126336248785228
TF TF:M03977 Factor: ETS1; motif: ACCGGAARYN 0.0203201577549649 10512 87 62 0.71264367816092 0.00589802130898021
TF TF:M11399 Factor: Fli-1; motif: NACCGGAWWTCCGGTY 0.0205693045379803 12977 30 28 0.933333333333333 0.00215766355860368
TF TF:M12313 Factor: ZNF460; motif: NNACNCCCCCCNN 0.0209817474203408 5825 134 58 0.432835820895522 0.00995708154506438
TF TF:M09813 Factor: MYB; motif: NNCAACTGNN 0.0212028619632244 5545 6 6 1 0.00108205590622182
TF TF:M03989 Factor: FLI1; motif: ACCGGAAATCCGGT 0.0212028619632244 10442 127 86 0.677165354330709 0.00823597012066654
TF TF:M03976 Factor: ERG; motif: ACCGGAWATCCGGT 0.0213211444424349 12803 134 105 0.783582089552239 0.00820120284308365
TF TF:M00146 Factor: HSF1; motif: AGAANRTTCN 0.0214735090861687 2678 40 14 0.35 0.00522778192681105
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.0215207098740538 13022 135 107 0.792592592592593 0.0082168637690063
TF TF:M08457_1 Factor: ER71:SREBP-2; motif: NTSACGTGACGGAARY; match class: 1 0.0215207098740538 5591 64 31 0.484375 0.00554462529064568
TF TF:M08568 Factor: ER71:E2A; motif: CASSTGNACCGGAWRYN 0.0216599983161667 18245 128 127 0.9921875 0.00696081118114552
TF TF:M08208 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC 0.023213301027684 12560 125 97 0.776 0.00772292993630573
TF TF:M11447 Factor: Elf-1; motif: NAMCCGGAAGTN 0.023213301027684 7703 86 49 0.569767441860465 0.00636115799039335
TF TF:M01073_1 Factor: HIC1; motif: NNNGGKTGCCCSNNNNNN; match class: 1 0.0238166848620333 762 11 4 0.363636363636364 0.005249343832021
TF TF:M02036_1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 0.0238166848620333 5290 126 51 0.404761904761905 0.00964083175803403
TF TF:M09764_1 Factor: ROX; motif: GNNNCASGTGGS; match class: 1 0.0242044709363649 1631 134 23 0.171641791044776 0.0141017780502759
TF TF:M01201_1 Factor: AR; motif: GGNACRNNRTGTWCT; match class: 1 0.0242044709363649 2129 5 4 0.8 0.00187881634570221
TF TF:M04636_1 Factor: TFII-I; motif: NAGGAAGTGN; match class: 1 0.0242044709363649 5733 6 6 1 0.0010465724751439
TF TF:M11727 Factor: NF-1B; motif: NTTGGCNNNNTGCCARN 0.0242044709363649 75 44 3 0.0681818181818182 0.04
TF TF:M11741 Factor: COUP-TF1; motif: RRGGTCRNTGACCYY 0.0242044709363649 3249 6 5 0.833333333333333 0.0015389350569406
TF TF:M00088 Factor: Ik-3; motif: TNYTGGGAATACC 0.0242044709363649 5762 6 6 1 0.001041305102395
TF TF:M09910 Factor: ER-beta; motif: RGGTCASCNTGMCCY 0.0242044709363649 9520 74 50 0.675675675675676 0.00525210084033613
TF TF:M09761 Factor: EGR1; motif: NGNGKGGGYGGNGS 0.0242044709363649 5162 126 50 0.396825396825397 0.00968616815187912
TF TF:M12280 Factor: MTF-1; motif: NTTTTGCACACGGCNNN 0.0245144634573547 6897 7 7 1 0.0010149340292881
TF TF:M01873 Factor: Egr-1; motif: GCGGGGGCGG 0.0246603546584385 6738 126 61 0.484126984126984 0.00905313149302464
TF TF:M05386 Factor: KLF17; motif: NGGGCGG 0.0247160660180002 7900 135 73 0.540740740740741 0.00924050632911392
TF TF:M01770 Factor: XBP-1; motif: WNNGMCACGTC 0.0247160660180002 11003 127 89 0.700787401574803 0.00808870308097791
TF TF:M08957 Factor: NURR1:RXR-ALPHA; motif: NRGGTCRTTGACCYN 0.0247160660180002 8851 128 76 0.59375 0.00858660038413738
TF TF:M05499 Factor: LKLF; motif: NGGGCGG 0.0247160660180002 7900 135 73 0.540740740740741 0.00924050632911392
TF TF:M08441_1 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 0.025355879832251 12761 121 95 0.785123966942149 0.00744455763654886
TF TF:M00483 Factor: ATF6; motif: TGACGTGG 0.0265734728688268 2627 10 6 0.6 0.00228397411496003
TF TF:M00333_1 Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 0.0267255786950033 12401 134 102 0.761194029850746 0.00822514313361826
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.0268442064254665 10116 135 88 0.651851851851852 0.00869909054962436
TF TF:M00054 Factor: NF-kappaB; motif: GGGAMTTYCC 0.0268442064254665 2444 22 9 0.409090909090909 0.00368248772504092
TF TF:M07406 Factor: SREBP-2; motif: RTGGGGTGAY 0.0277330698316304 5983 6 6 1 0.00100284138392111
TF TF:M12345 Factor: Zbtb37; motif: NYACCGCRNTCACCGCR 0.0277330698316304 5505 94 41 0.436170212765957 0.00744777475022707
TF TF:M00426 Factor: E2F; motif: TTTSGCGS 0.0277330698316304 11885 124 92 0.741935483870968 0.00774084981068574
TF TF:M05439 Factor: RREB-1; motif: GGGWCSA 0.0278489003851608 8635 77 48 0.623376623376623 0.00555877243775333
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.0281764444409575 8944 73 47 0.643835616438356 0.00525491949910555
TF TF:M03893 Factor: WT1; motif: GNGGGGGCGGGG 0.0281764444409575 8290 128 72 0.5625 0.00868516284680338
TF TF:M01972 Factor: EGR-1; motif: TGCGTGGGCGK 0.028245156521251 5360 126 51 0.404761904761905 0.00951492537313433
TF TF:M11274 Factor: XBP-1; motif: NGMCACRTCAYC 0.0283178520182734 1759 6 4 0.666666666666667 0.0022740193291643
TF TF:M00481_1 Factor: AR; motif: GGTACANNRTGTTCT; match class: 1 0.0283197403407738 2295 5 4 0.8 0.00174291938997821
TF TF:M10018 Factor: NRF-1; motif: CNSTGCGCATGCGCNNS 0.0283197403407738 1816 53 13 0.245283018867925 0.00715859030837004
TF TF:M08954 Factor: FXR:RXR-ALPHA; motif: NAGKTCATTGACCYN 0.0283197403407738 6443 9 8 0.888888888888889 0.00124165761291324
TF TF:M02052 Factor: EHF; motif: CSCGGAARTN 0.0283595450565414 10107 132 86 0.651515151515151 0.00850895419016523
TF TF:M09967 Factor: AP-2rep; motif: NGGGGCGGGGC 0.0287031565083023 4023 77 28 0.363636363636364 0.00695998011434253
TF TF:M01303 Factor: SP1; motif: GGGGYGGGGNS 0.0287031565083023 7898 121 66 0.545454545454545 0.00835654596100279
TF TF:M08523 Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN 0.0287031565083023 12160 119 90 0.756302521008403 0.00740131578947368
TF TF:M01001 Factor: DEAF1; motif: NCGNNYTCGGGNRTTTCCGDARNNN 0.0291910089425015 2295 59 16 0.271186440677966 0.00697167755991285
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.0295209814063319 3614 118 36 0.305084745762712 0.00996126175982291
TF TF:M10013 Factor: LXR-alpha; motif: NNRRGGTYACTNNAGGNCA 0.0295209814063319 3171 87 26 0.298850574712644 0.00819930621255125
TF TF:M07084_1 Factor: E2F-4; motif: NGGCGGGAARN; match class: 1 0.0295209814063319 5437 116 48 0.413793103448276 0.00882839801361045
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0300641274777269 13270 95 78 0.821052631578947 0.00587792012057272
TF TF:M00084_1 Factor: MZF-1; motif: KNGNKAGGGGNAA; match class: 1 0.0306819778906716 1683 110 20 0.181818181818182 0.011883541295306
TF TF:M07322 Factor: HSF4; motif: CTGCMRN 0.0307427218685864 16573 135 126 0.933333333333333 0.007602727327581
TF TF:M00470_1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 0.030931189992693 5600 119 50 0.420168067226891 0.00892857142857143
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.030931189992693 6334 45 25 0.555555555555556 0.00394695295232081
TF TF:M03976_1 Factor: ERG; motif: ACCGGAWATCCGGT; match class: 1 0.0320796345198811 7781 89 50 0.561797752808989 0.00642590926616116
TF TF:M11541_1 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 0.0323004953281199 5493 101 43 0.425742574257426 0.00782814491170581
TF TF:M09760 Factor: DPF2; motif: NYCACYTCCYCNYYCY 0.0323613102357805 8179 11 10 0.909090909090909 0.00122264335493337
TF TF:M03896 Factor: EGR1; motif: NACGCCCACGCANW 0.0328333252027323 6129 134 59 0.440298507462687 0.00962636645456029
TF TF:M10468 Factor: ZBRK1; motif: NGNNNGGTNAWAAAARRGCNG 0.0329705866322541 10941 20 18 0.9 0.00164518782561009
TF TF:M00069_1 Factor: YY1; motif: NNNCGGCCATCTTGNCTSNW; match class: 1 0.0333409640980639 2205 35 11 0.314285714285714 0.00498866213151927
TF TF:M11391_1 Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 0.0333409640980639 9085 46 32 0.695652173913043 0.00352228948816731
TF TF:M07248 Factor: CREB1; motif: NNNNTGACGTNANNN 0.0333824366577754 4266 135 45 0.333333333333333 0.0105485232067511
TF TF:M01117 Factor: OTX; motif: GATTANNT 0.0335238240654372 790 106 12 0.113207547169811 0.0151898734177215
TF TF:M11052 Factor: Hey2; motif: NNCACGYGNN 0.0336999064410358 12502 90 71 0.788888888888889 0.00567909134538474
TF TF:M08214 Factor: Elk-1:ETV7; motif: ANSCGGACGGATDTCCGGNT 0.0336999064410358 7951 134 72 0.537313432835821 0.00905546472141869
TF TF:M00052 Factor: NF-kappaB; motif: GGGRATTTCC 0.0336999064410358 1874 14 6 0.428571428571429 0.0032017075773746
TF TF:M04106_1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 0.0336999064410358 8372 126 71 0.563492063492063 0.00848064978499761
TF TF:M08980 Factor: VDR:RXR-ALPHA; motif: NRGGTCANNNGGTTCNN 0.0338151797756072 10442 43 33 0.767441860465116 0.00316031411606972
TF TF:M00004_1 Factor: c-Myb; motif: NCNRNNGRCNGTTGGKGG; match class: 1 0.0338274639422898 1883 14 6 0.428571428571429 0.00318640467339352
TF TF:M08878 Factor: EGR; motif: CGCCCCCGCNN 0.0338274639422898 7483 128 66 0.515625 0.00881999198182547
TF TF:M04715 Factor: Oct-2; motif: ATTTGCA 0.0338274639422898 6381 6 6 1 0.000940291490362012
TF TF:M08886_1 Factor: IRF4; motif: MNNRAAANGAAA; match class: 1 0.0338880798858791 938 26 6 0.230769230769231 0.00639658848614072
TF TF:M02034 Factor: TTF-1; motif: NNNCNCTTGASNNN 0.0346289907745719 3810 19 10 0.526315789473684 0.0026246719160105
TF TF:M08289_1 Factor: Fli-1:Max; motif: NCCGGAAACACGTGN; match class: 1 0.0348951546102433 3329 89 27 0.303370786516854 0.00811054370681887
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0352096381238414 6807 77 40 0.519480519480519 0.00587630380490671
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.0352096381238414 11728 134 97 0.723880597014925 0.00827080491132333
TF TF:M11066_1 Factor: HES-7; motif: GNCACGYGNN; match class: 1 0.0360093315653217 8172 90 52 0.577777777777778 0.00636319138521782
TF TF:M11081_1 Factor: SREBP-1; motif: RTCRCGTGAY; match class: 1 0.0360093315653217 7890 42 27 0.642857142857143 0.00342205323193916
TF TF:M09905 Factor: SAP-1; motif: NNCCGGAAGTGN 0.0365740933416505 8273 134 74 0.552238805970149 0.00894476006285507
TF TF:M03876 Factor: Kaiso; motif: GCMGGGRGCRGS 0.036989281328334 13622 46 41 0.891304347826087 0.00300983702833651
TF TF:M02071_1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 0.036989281328334 4465 134 46 0.343283582089552 0.0103023516237402
TF TF:M00025 Factor: Elk-1; motif: NNNNCCGGAARTNN 0.036989281328334 10262 135 88 0.651851851851852 0.00857532644708634
TF TF:M08443 Factor: AP-4:ER81; motif: RSCGGAAGCAGSTGNN 0.0371875571558842 10698 127 86 0.677165354330709 0.00803888577304169
TF TF:M09746 Factor: HNRPUL1; motif: NCNCAGN 0.0379229419114801 13720 25 24 0.96 0.00174927113702624
TF TF:M07034 Factor: ATF-1; motif: NNNTGACGTNNN 0.0381785342852599 4248 10 7 0.7 0.00164783427495292
TF TF:M00039 Factor: CREB; motif: TGACGTMA 0.0388183227711194 5222 135 52 0.385185185185185 0.00995787054768288
TF TF:M02036 Factor: WT1; motif: CGCCCCCNCN 0.0388183227711194 9767 76 51 0.671052631578947 0.00522166478959762
TF TF:M02090_1 Factor: E2F-4; motif: GCGGGAAANA; match class: 1 0.0388183227711194 6378 128 58 0.453125 0.00909375979931013
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.0388183227711194 8227 135 74 0.548148148148148 0.00899477330740246
TF TF:M11052_1 Factor: Hey2; motif: NNCACGYGNN; match class: 1 0.0388183227711194 9523 90 58 0.644444444444444 0.00609051769400399
TF TF:M07056 Factor: Pitx2; motif: WNTAAWCCCA 0.0388183227711194 4685 19 11 0.578947368421053 0.00234791889007471
TF TF:M00208 Factor: NF-kappaB; motif: NGGGACTTTCCA 0.0388183227711194 3757 11 7 0.636363636363636 0.00186318871439979
TF TF:M02114 Factor: pitx2; motif: NNTAAWCCCA 0.0388183227711194 4685 19 11 0.578947368421053 0.00234791889007471
TF TF:M11541 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN 0.0388183227711194 5751 101 44 0.435643564356436 0.00765084333159451
TF TF:M01168 Factor: SREBP; motif: NNNNYCACNCCANNN 0.0388244060141421 6651 6 6 1 0.0009021199819576
TF TF:M02063 Factor: c-ets-1; motif: ACCGGAWGTN 0.0388244060141421 7600 92 50 0.543478260869565 0.00657894736842105
TF TF:M00916 Factor: CREB; motif: NNTKACGTCANNNS 0.0388244060141421 5889 135 57 0.422222222222222 0.00967906265919511
TF TF:M04026_1 Factor: SMAD3; motif: YGTCTAGACA; match class: 1 0.0399024658079572 6085 22 14 0.636363636363636 0.00230073952341824
TF TF:M00341 Factor: GABP; motif: VCCGGAAGNGCR 0.040037088678701 8224 76 45 0.592105263157895 0.00547178988326848
TF TF:M12279 Factor: MTF-1; motif: NTTTTGCACACGGCNYN 0.0403951455208891 6713 6 6 1 0.000893788172203188
TF TF:M00737 Factor: E2F-1:DP-2; motif: TTTSSCGC 0.040864776061381 8771 126 73 0.579365079365079 0.0083228822255159
TF TF:M09606 Factor: nerf; motif: NRRNSCGGAAGNRNNNN 0.040864776061381 6249 123 55 0.447154471544715 0.00880140822531605
TF TF:M12230 Factor: LRF; motif: RCGACCACCNN 0.040864776061381 8543 125 71 0.568 0.00831089781107339
TF TF:M04818 Factor: IRF-4; motif: RGGAASWGR 0.040864776061381 9372 70 46 0.657142857142857 0.0049082373026035
TF TF:M08826 Factor: NF-E4; motif: GTGAGGS 0.040864776061381 11318 106 76 0.716981132075472 0.00671496730871179
TF TF:M00929 Factor: MyoD; motif: CNGNRNCAGGTGNNGNAN 0.040864776061381 1488 4 3 0.75 0.00201612903225806
TF TF:M01660 Factor: GABP-alpha; motif: CTTCCK 0.040864776061381 11116 125 87 0.696 0.0078265563152213
TF TF:M07612_1 Factor: PSF; motif: KWATCCGN; match class: 1 0.040864776061381 1117 69 11 0.159420289855072 0.00984780662488809
TF TF:M06203 Factor: ZXDA; motif: NAGGGTG 0.0410961743239779 7463 132 67 0.507575757575758 0.00897762293983653
TF TF:M06202 Factor: ZXDB; motif: NAGGGTG 0.0410961743239779 7463 132 67 0.507575757575758 0.00897762293983653
TF TF:M10094 Factor: RelA-p65; motif: NWGGGRATTTCCMN 0.0411489450271016 2429 12 6 0.5 0.00247015232606011
TF TF:M08803 Factor: CREM; motif: NNTGACGT 0.0412936322621567 1124 10 4 0.4 0.00355871886120996
TF TF:M07052 Factor: NRF-1; motif: GCGCMTGCGCN 0.0412936322621567 2130 73 17 0.232876712328767 0.007981220657277
TF TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 0.0417527423057639 4556 28 14 0.5 0.00307287093942054
TF TF:M11397_1 Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 0.0418804697308146 11731 63 49 0.777777777777778 0.00417696701048504
TF TF:M11743_1 Factor: COUP-TF1; motif: RAGGTCANYGACCTY; match class: 1 0.0418804697308146 4014 4 4 1 0.000996512207274539
TF TF:M01783_1 Factor: SP2; motif: GGGCGGGAC; match class: 1 0.042923818388384 4333 75 28 0.373333333333333 0.00646203554119548
TF TF:M02066 Factor: PEA3; motif: RCCGGAAGYN 0.042923818388384 7045 92 47 0.510869565217391 0.00667139815471966
TF TF:M02012_1 Factor: HIF-1alpha; motif: NCACGT; match class: 1 0.0434363756490427 1770 95 18 0.189473684210526 0.0101694915254237
TF TF:M07312 Factor: ATF-2; motif: NNTGACGTCAN 0.0434363756490427 3483 131 37 0.282442748091603 0.0106230261269021
TF TF:M00749_1 Factor: SREBP-1; motif: CACSCCA; match class: 1 0.0438659009267104 2768 22 9 0.409090909090909 0.0032514450867052
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.0438659009267104 3783 93 30 0.32258064516129 0.00793021411578113
TF TF:M11391 Factor: Erg; motif: NACCGGATATCCGGTN 0.0438659009267104 10082 83 56 0.674698795180723 0.00555445348145209
TF TF:M12159 Factor: KLF15; motif: GCCACGCCCMCN 0.043998641163983 1422 64 12 0.1875 0.00843881856540084
TF TF:M04744_1 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 0.0440484782227337 4889 135 49 0.362962962962963 0.010022499488648
TF TF:M10042_1 Factor: PR; motif: RGNACATTYTGTNCTN; match class: 1 0.0447054171374952 998 36 7 0.194444444444444 0.00701402805611222
TF TF:M07405 Factor: SREBP-1; motif: RTCACCCCAY 0.0452289513330746 6972 6 6 1 0.000860585197934596
TF TF:M12005_1 Factor: GMEB-1; motif: KNACGTNRNNACGTAN; match class: 1 0.0453638827996321 471 23 4 0.173913043478261 0.00849256900212314
TF TF:M04054_1 Factor: NF-kappaB; motif: AGGGGAWTCCCCT; match class: 1 0.0453638827996321 1295 99 15 0.151515151515152 0.0115830115830116
TF TF:M04903 Factor: HNF-4alpha; motif: AGTCCAAR 0.0453638827996321 6987 6 6 1 0.0008587376556462
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.0453638827996321 4199 118 39 0.330508474576271 0.00928792569659443
TF TF:M00801 Factor: CREB; motif: CGTCAN 0.0463322213680186 4326 62 24 0.387096774193548 0.00554785020804438
TF TF:M11393 Factor: Erg; motif: NACCGGATATCCGGTN 0.0466883353740483 14105 83 71 0.855421686746988 0.00503367600141794
TF TF:M00469_1 Factor: AP-2alpha; motif: GCCNNNRGS; match class: 1 0.0466883353740483 3334 119 33 0.277310924369748 0.00989802039592082
TF TF:M08897_1 Factor: SMAD; motif: TGTCTGNNN; match class: 1 0.0472077952814492 661 17 4 0.235294117647059 0.00605143721633888
TF TF:M00143 Factor: Pax-5; motif: BCNNNRNGCANBGNTGNRTAGCSGCHNB 0.0481251173726843 11392 131 92 0.702290076335878 0.00807584269662921
TF TF:M09668 Factor: RelA-p65; motif: GGGRNTTTCCM 0.0481391939421601 3576 12 7 0.583333333333333 0.00195749440715884
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0481410502093343 7728 118 62 0.525423728813559 0.00802277432712215
TF TF:M00481 Factor: AR; motif: GGTACANNRTGTTCT 0.0481728099285585 4981 49 22 0.448979591836735 0.00441678377835776
TF TF:M00915 Factor: AP-2; motif: SNNNCCNCAGGCN 0.0492646946466129 9612 94 60 0.638297872340426 0.00624219725343321
TF TF:M00224 Factor: STAT1; motif: NNNSANTTCCGGGAANTGNSN 0.0492646946466129 5609 29 16 0.551724137931034 0.00285255838830451
TF TF:M03906 Factor: HIC2; motif: RTGCCCRNN 0.0492646946466129 3458 22 10 0.454545454545455 0.00289184499710815
TF TF:M07603 Factor: Dlx-3; motif: NNNYNAATTAAN 0.0494452280781655 812 45 7 0.155555555555556 0.00862068965517241
WP WP:WP3529 Zinc homeostasis 1.25459625055927e-12 37 6 6 1 0.162162162162162
WP WP:WP3286 Copper homeostasis 6.968962357702e-12 54 6 6 1 0.111111111111111

pEpiTp02 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp02
Possible regulators of activation of pEpiTp02 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.