pM22 program activity among Myeloid cells

Activation of pM22
pM22 gene program activation in Myeloid cells.
Gene program activation of pM22 by different cell subtypes
pM22 gene program activation among cells of different subtypes (Myeloid cells).

pM22 top program genes

Top genes of pM22 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pM22 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pM22
pM22 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 1.39984113691543e-15 103 12 9 0.75 0.087378640776699
GO:BP GO:0019882 antigen processing and presentation 1.39984113691543e-15 234 20 12 0.6 0.0512820512820513
GO:BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 1.12153801352554e-13 96 12 8 0.666666666666667 0.0833333333333333
GO:BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 1.17951635674706e-13 100 12 8 0.666666666666667 0.08
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 2.63595133700388e-13 182 27 11 0.407407407407407 0.0604395604395604
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 7.37065686410312e-12 174 12 8 0.666666666666667 0.0459770114942529
GO:BP GO:0002399 MHC class II protein complex assembly 8.76881452624091e-12 4 10 4 0.4 1
GO:BP GO:0002503 peptide antigen assembly with MHC class II protein complex 8.76881452624091e-12 4 10 4 0.4 1
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 1.09299960701909e-11 192 12 8 0.666666666666667 0.0416666666666667
GO:BP GO:0002250 adaptive immune response 5.48447086268006e-11 689 12 10 0.833333333333333 0.0145137880986938
GO:BP GO:0002501 peptide antigen assembly with MHC protein complex 9.56091003913182e-11 6 10 4 0.4 0.666666666666667
GO:BP GO:0002396 MHC protein complex assembly 2.04443046323999e-10 7 10 4 0.4 0.571428571428571
GO:BP GO:0050776 regulation of immune response 2.2917578572972e-10 996 20 13 0.65 0.0130522088353414
GO:BP GO:0006955 immune response 2.2917578572972e-10 2311 21 17 0.80952380952381 0.00735612289052358
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 5.50003877027909e-10 88 21 7 0.333333333333333 0.0795454545454545
GO:BP GO:0034341 response to interferon-gamma 2.7484307195302e-09 196 21 8 0.380952380952381 0.0408163265306122
GO:BP GO:0019883 antigen processing and presentation of endogenous antigen 5.45232449515958e-09 26 20 5 0.25 0.192307692307692
GO:BP GO:0002468 dendritic cell antigen processing and presentation 1.32297695215535e-08 14 13 4 0.307692307692308 0.285714285714286
GO:BP GO:0002286 T cell activation involved in immune response 2.92917510681658e-08 112 16 6 0.375 0.0535714285714286
GO:BP GO:0050870 positive regulation of T cell activation 4.40456172287136e-08 219 10 6 0.6 0.0273972602739726
GO:BP GO:0002376 immune system process 4.67783532229828e-08 3278 21 17 0.80952380952381 0.00518608907870653
GO:BP GO:0022407 regulation of cell-cell adhesion 4.69280669019939e-08 445 15 8 0.533333333333333 0.0179775280898876
GO:BP GO:0071346 cellular response to interferon-gamma 4.70374946099897e-08 175 21 7 0.333333333333333 0.04
GO:BP GO:0002682 regulation of immune system process 5.79858951386227e-08 1617 20 13 0.65 0.0080395794681509
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 5.92937130078402e-08 338 48 11 0.229166666666667 0.0325443786982249
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 6.03016911144214e-08 241 10 6 0.6 0.024896265560166
GO:BP GO:0050863 regulation of T cell activation 6.26853059574276e-08 337 13 7 0.538461538461538 0.0207715133531157
GO:BP GO:0001916 positive regulation of T cell mediated cytotoxicity 9.15529836537341e-08 26 37 5 0.135135135135135 0.192307692307692
GO:BP GO:0050778 positive regulation of immune response 9.48873402541168e-08 753 20 10 0.5 0.0132802124833997
GO:BP GO:0007159 leukocyte cell-cell adhesion 1.18613483923416e-07 375 13 7 0.538461538461538 0.0186666666666667
GO:BP GO:0042110 T cell activation 1.32662330534822e-07 489 16 8 0.5 0.016359918200409
GO:BP GO:0022409 positive regulation of cell-cell adhesion 1.32662330534822e-07 284 10 6 0.6 0.0211267605633803
GO:BP GO:0046649 lymphocyte activation 3.23841018719557e-07 771 48 14 0.291666666666667 0.0181582360570687
GO:BP GO:0001914 regulation of T cell mediated cytotoxicity 3.67188722123793e-07 35 37 5 0.135135135135135 0.142857142857143
GO:BP GO:0002285 lymphocyte activation involved in immune response 3.86400343562996e-07 190 16 6 0.375 0.0315789473684211
GO:BP GO:0051251 positive regulation of lymphocyte activation 5.24353882028143e-07 365 10 6 0.6 0.0164383561643836
GO:BP GO:0050852 T cell receptor signaling pathway 6.20114763629943e-07 203 4 4 1 0.0197044334975369
GO:BP GO:0001913 T cell mediated cytotoxicity 8.52066433837018e-07 42 37 5 0.135135135135135 0.119047619047619
GO:BP GO:0051249 regulation of lymphocyte activation 8.5250657211439e-07 518 13 7 0.538461538461538 0.0135135135135135
GO:BP GO:0045321 leukocyte activation 8.6152001131431e-07 1332 48 17 0.354166666666667 0.0127627627627628
GO:BP GO:0002696 positive regulation of leukocyte activation 9.48186403149878e-07 412 10 6 0.6 0.0145631067961165
GO:BP GO:0002684 positive regulation of immune system process 1.06043086966136e-06 1065 40 14 0.35 0.0131455399061033
GO:BP GO:0050867 positive regulation of cell activation 1.07267320216912e-06 424 10 6 0.6 0.0141509433962264
GO:BP GO:0006952 defense response 1.17463553345695e-06 1818 30 15 0.5 0.00825082508250825
GO:BP GO:0045785 positive regulation of cell adhesion 1.17463553345695e-06 437 10 6 0.6 0.0137299771167048
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 1.23794855913426e-06 512 14 7 0.5 0.013671875
GO:BP GO:0030155 regulation of cell adhesion 1.23794855913426e-06 748 15 8 0.533333333333333 0.0106951871657754
GO:BP GO:0002764 immune response-regulating signaling pathway 1.24646023888654e-06 515 14 7 0.5 0.0135922330097087
GO:BP GO:0002711 positive regulation of T cell mediated immunity 1.2666819126641e-06 48 37 5 0.135135135135135 0.104166666666667
GO:BP GO:0098609 cell-cell adhesion 1.32679726877215e-06 894 48 14 0.291666666666667 0.0156599552572707
GO:BP GO:0098542 defense response to other organism 1.54182621104276e-06 1218 27 12 0.444444444444444 0.00985221674876847
GO:BP GO:0001912 positive regulation of leukocyte mediated cytotoxicity 1.63394390961057e-06 51 37 5 0.135135135135135 0.0980392156862745
GO:BP GO:0043380 regulation of memory T cell differentiation 1.69335431406148e-06 12 13 3 0.230769230769231 0.25
GO:BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.69335431406148e-06 96 40 6 0.15 0.0625
GO:BP GO:0002694 regulation of leukocyte activation 1.79343908845702e-06 610 13 7 0.538461538461538 0.0114754098360656
GO:BP GO:0050670 regulation of lymphocyte proliferation 1.95267345479505e-06 230 10 5 0.5 0.0217391304347826
GO:BP GO:0032944 regulation of mononuclear cell proliferation 2.00433163352985e-06 232 10 5 0.5 0.021551724137931
GO:BP GO:0043379 memory T cell differentiation 2.05375241091526e-06 13 13 3 0.230769230769231 0.230769230769231
GO:BP GO:0002821 positive regulation of adaptive immune response 2.09025818408728e-06 101 40 6 0.15 0.0594059405940594
GO:BP GO:0002699 positive regulation of immune effector process 2.12485176730709e-06 215 20 6 0.3 0.027906976744186
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 2.36033252007703e-06 323 4 4 1 0.0123839009287926
GO:BP GO:0090715 immunological memory formation process 2.44948525229355e-06 14 13 3 0.230769230769231 0.214285714285714
GO:BP GO:0050865 regulation of cell activation 2.55997038957904e-06 655 13 7 0.538461538461538 0.0106870229007634
GO:BP GO:0070663 regulation of leukocyte proliferation 2.65292113819457e-06 251 10 5 0.5 0.0199203187250996
GO:BP GO:0031343 positive regulation of cell killing 2.75103630980977e-06 59 37 5 0.135135135135135 0.0847457627118644
GO:BP GO:0001775 cell activation 2.75103630980977e-06 1495 48 17 0.354166666666667 0.011371237458194
GO:BP GO:0090713 immunological memory process 4.23909911560704e-06 17 13 3 0.230769230769231 0.176470588235294
GO:BP GO:0032649 regulation of interferon-gamma production 4.66401132949384e-06 110 3 3 1 0.0272727272727273
GO:BP GO:0032609 interferon-gamma production 5.26062669671305e-06 115 3 3 1 0.0260869565217391
GO:BP GO:0002757 immune response-activating signal transduction 5.28208535564566e-06 477 12 6 0.5 0.0125786163522013
GO:BP GO:0046651 lymphocyte proliferation 5.28208535564566e-06 294 10 5 0.5 0.0170068027210884
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 5.28208535564566e-06 477 12 6 0.5 0.0125786163522013
GO:BP GO:0032943 mononuclear cell proliferation 5.39117374770901e-06 297 10 5 0.5 0.0168350168350168
GO:BP GO:0001910 regulation of leukocyte mediated cytotoxicity 7.31118213813905e-06 74 37 5 0.135135135135135 0.0675675675675676
GO:BP GO:0002697 regulation of immune effector process 7.31118213813905e-06 461 20 7 0.35 0.0151843817787419
GO:BP GO:0002709 regulation of T cell mediated immunity 7.31118213813905e-06 74 37 5 0.135135135135135 0.0675675675675676
GO:BP GO:0070661 leukocyte proliferation 7.80428781011123e-06 325 10 5 0.5 0.0153846153846154
GO:BP GO:0030098 lymphocyte differentiation 9.73847661775236e-06 376 48 9 0.1875 0.023936170212766
GO:BP GO:0045087 innate immune response 1.05050379556589e-05 998 26 10 0.384615384615385 0.0100200400801603
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 1.27049949933909e-05 141 10 4 0.4 0.0283687943262411
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 1.27658263883938e-05 142 10 4 0.4 0.028169014084507
GO:BP GO:0002253 activation of immune response 1.27658263883938e-05 568 12 6 0.5 0.0105633802816901
GO:BP GO:0002449 lymphocyte mediated immunity 1.50742147382952e-05 354 40 8 0.2 0.0225988700564972
GO:BP GO:0042129 regulation of T cell proliferation 1.53543696117383e-05 176 3 3 1 0.0170454545454545
GO:BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.61384806940222e-05 152 40 6 0.15 0.0394736842105263
GO:BP GO:0051707 response to other organism 1.65193546615327e-05 1592 27 12 0.444444444444444 0.00753768844221105
GO:BP GO:0043207 response to external biotic stimulus 1.65193546615327e-05 1594 27 12 0.444444444444444 0.00752823086574655
GO:BP GO:0019221 cytokine-mediated signaling pathway 1.65193546615327e-05 810 6 5 0.833333333333333 0.00617283950617284
GO:BP GO:0070665 positive regulation of leukocyte proliferation 1.65826053437568e-05 155 10 4 0.4 0.0258064516129032
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.6669181493393e-05 363 40 8 0.2 0.0220385674931129
GO:BP GO:0002366 leukocyte activation involved in immune response 1.91022490418522e-05 717 16 7 0.4375 0.0097629009762901
GO:BP GO:0031341 regulation of cell killing 1.91022490418522e-05 93 37 5 0.135135135135135 0.0537634408602151
GO:BP GO:0009607 response to biotic stimulus 1.93962046841151e-05 1626 27 12 0.444444444444444 0.00738007380073801
GO:BP GO:0002263 cell activation involved in immune response 1.94279098449209e-05 721 16 7 0.4375 0.00970873786407767
GO:BP GO:0042098 T cell proliferation 2.1192070533429e-05 205 3 3 1 0.0146341463414634
GO:BP GO:0002456 T cell mediated immunity 2.333412711759e-05 98 37 5 0.135135135135135 0.0510204081632653
GO:BP GO:1903131 mononuclear cell differentiation 2.36190871868745e-05 430 48 9 0.1875 0.0209302325581395
GO:BP GO:0002819 regulation of adaptive immune response 2.39267837457075e-05 167 40 6 0.15 0.0359281437125748
GO:BP GO:0002443 leukocyte mediated immunity 2.91242300714132e-05 877 40 11 0.275 0.0125427594070696
GO:BP GO:0002708 positive regulation of lymphocyte mediated immunity 3.01381467934194e-05 104 37 5 0.135135135135135 0.0480769230769231
GO:BP GO:0045582 positive regulation of T cell differentiation 3.39766012238152e-05 91 6 3 0.5 0.032967032967033
GO:BP GO:0001909 leukocyte mediated cytotoxicity 3.40436060467134e-05 107 37 5 0.135135135135135 0.0467289719626168
GO:BP GO:0002252 immune effector process 3.60486213099855e-05 1309 40 13 0.325 0.00993124522536287
GO:BP GO:0045580 regulation of T cell differentiation 4.37523747002679e-05 152 13 4 0.307692307692308 0.0263157894736842
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 4.90155473504225e-05 104 6 3 0.5 0.0288461538461538
GO:BP GO:0007155 cell adhesion 5.46658625096419e-05 1492 48 15 0.3125 0.0100536193029491
GO:BP GO:0022610 biological adhesion 5.74027350938747e-05 1499 48 15 0.3125 0.0100066711140761
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 6.15116849664655e-05 122 37 5 0.135135135135135 0.040983606557377
GO:BP GO:0071345 cellular response to cytokine stimulus 6.88400851079472e-05 1132 6 5 0.833333333333333 0.00441696113074205
GO:BP GO:0045619 regulation of lymphocyte differentiation 7.78344837020513e-05 180 13 4 0.307692307692308 0.0222222222222222
GO:BP GO:0034097 response to cytokine 9.79934391953275e-05 1226 6 5 0.833333333333333 0.00407830342577488
GO:BP GO:0002521 leukocyte differentiation 0.000144621056895758 550 48 9 0.1875 0.0163636363636364
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.000149038734717845 157 6 3 0.5 0.0191082802547771
GO:BP GO:1903708 positive regulation of hemopoiesis 0.000149038734717845 157 6 3 0.5 0.0191082802547771
GO:BP GO:0002577 regulation of antigen processing and presentation 0.000152262081415488 21 40 3 0.075 0.142857142857143
GO:BP GO:0002706 regulation of lymphocyte mediated immunity 0.000154940203227412 151 37 5 0.135135135135135 0.033112582781457
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.000184348975043182 194 15 4 0.266666666666667 0.0206185567010309
GO:BP GO:0046596 regulation of viral entry into host cell 0.000185384909696898 43 21 3 0.142857142857143 0.0697674418604651
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.000209532362862445 1455 6 5 0.833333333333333 0.00343642611683849
GO:BP GO:0002292 T cell differentiation involved in immune response 0.000211609274650465 75 13 3 0.230769230769231 0.04
GO:BP GO:0006950 response to stress 0.000217516475286287 4170 33 19 0.575757575757576 0.00455635491606715
GO:BP GO:0042102 positive regulation of T cell proliferation 0.000234323278100177 104 10 3 0.3 0.0288461538461538
GO:BP GO:0048584 positive regulation of response to stimulus 0.000255159017530379 2344 12 8 0.666666666666667 0.00341296928327645
GO:BP GO:0052372 modulation by symbiont of entry into host 0.000266855192455727 50 21 3 0.142857142857143 0.06
GO:BP GO:0030217 T cell differentiation 0.000273657473670199 260 13 4 0.307692307692308 0.0153846153846154
GO:BP GO:0001906 cell killing 0.000273657473670199 175 37 5 0.135135135135135 0.0285714285714286
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.000385264172799631 2255 27 12 0.444444444444444 0.00532150776053215
GO:BP GO:1902105 regulation of leukocyte differentiation 0.000396436181252598 288 13 4 0.307692307692308 0.0138888888888889
GO:BP GO:0048583 regulation of response to stimulus 0.000490581394380475 4278 42 22 0.523809523809524 0.00514258999532492
GO:BP GO:0001817 regulation of cytokine production 0.000521636324886125 806 6 4 0.666666666666667 0.00496277915632754
GO:BP GO:0002703 regulation of leukocyte mediated immunity 0.000547637385125583 205 37 5 0.135135135135135 0.024390243902439
GO:BP GO:0001816 cytokine production 0.00061342386577988 844 6 4 0.666666666666667 0.004739336492891
GO:BP GO:0009605 response to external stimulus 0.000697299980064633 2944 40 17 0.425 0.00577445652173913
GO:BP GO:0050868 negative regulation of T cell activation 0.000750445927510869 123 13 3 0.230769230769231 0.024390243902439
GO:BP GO:0007162 negative regulation of cell adhesion 0.000808384325682481 304 15 4 0.266666666666667 0.0131578947368421
GO:BP GO:0050896 response to stimulus 0.00104401066173463 9407 22 20 0.909090909090909 0.00212607632614011
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.00110932762535865 142 13 3 0.230769230769231 0.0211267605633803
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.00144001776315284 156 13 3 0.230769230769231 0.0192307692307692
GO:BP GO:1903706 regulation of hemopoiesis 0.00152310115428542 424 13 4 0.307692307692308 0.00943396226415094
GO:BP GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 0.00180179343267413 53 40 3 0.075 0.0566037735849057
GO:BP GO:0002831 regulation of response to biotic stimulus 0.00222950500732411 415 26 5 0.192307692307692 0.0120481927710843
GO:BP GO:0001819 positive regulation of cytokine production 0.00229179307770819 452 37 6 0.162162162162162 0.0132743362831858
GO:BP GO:0002695 negative regulation of leukocyte activation 0.00236047030696136 188 13 3 0.230769230769231 0.0159574468085106
GO:BP GO:0045581 negative regulation of T cell differentiation 0.00237899777315827 49 48 3 0.0625 0.0612244897959184
GO:BP GO:0032101 regulation of response to external stimulus 0.00251483581148823 1051 39 9 0.230769230769231 0.00856327307326356
GO:BP GO:0051239 regulation of multicellular organismal process 0.00257989830005627 2861 8 6 0.75 0.00209716882209018
GO:BP GO:0050866 negative regulation of cell activation 0.00322405621998903 211 13 3 0.230769230769231 0.014218009478673
GO:BP GO:0071310 cellular response to organic substance 0.00339446022506144 2776 6 5 0.833333333333333 0.00180115273775216
GO:BP GO:0045620 negative regulation of lymphocyte differentiation 0.0035325491831138 57 48 3 0.0625 0.0526315789473684
GO:BP GO:0046718 viral entry into host cell 0.00415082305023873 141 21 3 0.142857142857143 0.0212765957446809
GO:BP GO:0030097 hemopoiesis 0.00480645092800929 928 48 9 0.1875 0.00969827586206897
GO:BP GO:1903900 regulation of viral life cycle 0.00513663361243211 153 21 3 0.142857142857143 0.0196078431372549
GO:BP GO:0044409 entry into host 0.00514650518572394 154 21 3 0.142857142857143 0.0194805194805195
GO:BP GO:0002440 production of molecular mediator of immune response 0.00555398364157369 189 40 4 0.1 0.0211640211640212
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.00607277167211977 966 48 9 0.1875 0.0093167701863354
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00626999049886466 3210 6 5 0.833333333333333 0.00155763239875389
GO:BP GO:0042127 regulation of cell population proliferation 0.00656639483931163 1774 3 3 1 0.00169109357384442
GO:BP GO:0052126 movement in host environment 0.00729893225652646 177 21 3 0.142857142857143 0.0169491525423729
GO:BP GO:0065003 protein-containing complex assembly 0.00782151912822398 1680 10 5 0.5 0.00297619047619048
GO:BP GO:0070887 cellular response to chemical stimulus 0.00786050025419352 3393 6 5 0.833333333333333 0.00147362216327734
GO:BP GO:0010033 response to organic substance 0.00803861531489435 3412 6 5 0.833333333333333 0.00146541617819461
GO:BP GO:0002520 immune system development 0.00836352607624237 1020 48 9 0.1875 0.00882352941176471
GO:BP GO:0031347 regulation of defense response 0.0087168953846631 704 22 5 0.227272727272727 0.00710227272727273
GO:BP GO:0050792 regulation of viral process 0.00882404342299578 192 21 3 0.142857142857143 0.015625
GO:BP GO:0002377 immunoglobulin production 0.00882404342299578 99 40 3 0.075 0.0303030303030303
GO:BP GO:0008284 positive regulation of cell population proliferation 0.00898427737069707 982 10 4 0.4 0.00407331975560081
GO:BP GO:0016064 immunoglobulin mediated immune response 0.0092820954008143 223 40 4 0.1 0.0179372197309417
GO:BP GO:0008283 cell population proliferation 0.00932321255963767 2054 3 3 1 0.00146056475170399
GO:BP GO:0019724 B cell mediated immunity 0.00962495687623172 226 40 4 0.1 0.0176991150442478
GO:BP GO:0042113 B cell activation 0.00995513251351793 330 47 5 0.106382978723404 0.0151515151515152
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 0.00995513251351793 203 21 3 0.142857142857143 0.0147783251231527
GO:BP GO:0051701 biological process involved in interaction with host 0.0119364362601568 221 21 3 0.142857142857143 0.0135746606334842
GO:BP GO:0045597 positive regulation of cell differentiation 0.0119364362601568 879 6 3 0.5 0.00341296928327645
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0124637150715464 1107 10 4 0.4 0.003613369467028
GO:BP GO:0043933 protein-containing complex subunit organization 0.0133049002133584 1963 10 5 0.5 0.00254712175241977
GO:BP GO:0016032 viral process 0.0138718873695761 942 6 3 0.5 0.00318471337579618
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0157148880347582 1001 6 3 0.5 0.002997002997003
GO:BP GO:0002683 negative regulation of immune system process 0.0157148880347582 420 13 3 0.230769230769231 0.00714285714285714
GO:BP GO:0002274 myeloid leukocyte activation 0.0157148880347582 667 17 4 0.235294117647059 0.00599700149925037
GO:BP GO:0031348 negative regulation of defense response 0.0164931517408028 246 22 3 0.136363636363636 0.0121951219512195
GO:BP GO:0002687 positive regulation of leukocyte migration 0.0165481396370858 137 39 3 0.0769230769230769 0.0218978102189781
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0178371980856154 1160 17 5 0.294117647058824 0.00431034482758621
GO:BP GO:0010628 positive regulation of gene expression 0.0216575392866083 1160 6 3 0.5 0.00258620689655172
GO:BP GO:0042221 response to chemical 0.022568521985808 4781 4 4 1 0.000836645053336122
GO:BP GO:0048518 positive regulation of biological process 0.0237506983596214 6363 48 26 0.541666666666667 0.00408612289800409
GO:BP GO:0002833 positive regulation of response to biotic stimulus 0.023889107213806 250 26 3 0.115384615384615 0.012
GO:BP GO:0061337 cardiac conduction 0.0239828120364081 150 43 3 0.0697674418604651 0.02
GO:BP GO:0030183 B cell differentiation 0.0248841484470949 140 47 3 0.0638297872340425 0.0214285714285714
GO:BP GO:0080134 regulation of response to stress 0.0267774774102838 1443 22 6 0.272727272727273 0.00415800415800416
GO:BP GO:0023052 signaling 0.0279022859705253 6810 48 27 0.5625 0.0039647577092511
GO:BP GO:0006954 inflammatory response 0.0280810995988026 794 39 6 0.153846153846154 0.00755667506297229
GO:BP GO:0051094 positive regulation of developmental process 0.0287710189895208 1341 6 3 0.5 0.00223713646532438
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.029599350963427 3483 3 3 1 0.000861326442721792
GO:BP GO:2000026 regulation of multicellular organismal development 0.0339081664479563 1447 6 3 0.5 0.00207325501036628
GO:BP GO:0009893 positive regulation of metabolic process 0.0355179602562922 3783 3 3 1 0.000793021411578113
GO:BP GO:0048522 positive regulation of cellular process 0.0379357846598533 5757 4 4 1 0.000694806322737537
GO:BP GO:0002685 regulation of leukocyte migration 0.0385811300759057 211 39 3 0.0769230769230769 0.014218009478673
GO:BP GO:0035637 multicellular organismal signaling 0.0444336412416779 204 43 3 0.0697674418604651 0.0147058823529412
GO:BP GO:0032102 negative regulation of response to external stimulus 0.0444336412416779 406 22 3 0.136363636363636 0.00738916256157635
GO:BP GO:0050920 regulation of chemotaxis 0.044480682121563 226 39 3 0.0769230769230769 0.0132743362831858
GO:BP GO:0045595 regulation of cell differentiation 0.0447904628783357 1679 6 3 0.5 0.00178677784395473
GO:CC GO:0042613 MHC class II protein complex 5.19673728591719e-25 16 12 9 0.75 0.5625
GO:CC GO:0042611 MHC protein complex 2.96635066916078e-23 24 12 9 0.75 0.375
GO:CC GO:0098553 lumenal side of endoplasmic reticulum membrane 1.13634213277821e-13 25 12 6 0.5 0.24
GO:CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 1.13634213277821e-13 25 12 6 0.5 0.24
GO:CC GO:0030669 clathrin-coated endocytic vesicle membrane 1.94228389764517e-13 36 40 8 0.2 0.222222222222222
GO:CC GO:0098576 lumenal side of membrane 4.72743962763518e-13 33 12 6 0.5 0.181818181818182
GO:CC GO:0098852 lytic vacuole membrane 2.39442383947119e-12 383 12 9 0.75 0.0234986945169713
GO:CC GO:0005765 lysosomal membrane 2.39442383947119e-12 383 12 9 0.75 0.0234986945169713
GO:CC GO:0045334 clathrin-coated endocytic vesicle 3.61110728031094e-12 54 40 8 0.2 0.148148148148148
GO:CC GO:0005774 vacuolar membrane 6.84283471661522e-12 441 12 9 0.75 0.0204081632653061
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 8.3935808074057e-12 57 12 6 0.5 0.105263157894737
GO:CC GO:0098797 plasma membrane protein complex 6.85120844489229e-11 694 47 16 0.340425531914894 0.0230547550432277
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 1.20767505572247e-10 90 12 6 0.5 0.0666666666666667
GO:CC GO:0032588 trans-Golgi network membrane 1.46491719448623e-10 94 12 6 0.5 0.0638297872340425
GO:CC GO:0000323 lytic vacuole 2.69293299649401e-10 712 20 11 0.55 0.0154494382022472
GO:CC GO:0005764 lysosome 2.69293299649401e-10 712 20 11 0.55 0.0154494382022472
GO:CC GO:0030665 clathrin-coated vesicle membrane 3.9300375325931e-10 114 12 6 0.5 0.0526315789473684
GO:CC GO:0010008 endosome membrane 6.0921389729531e-10 505 16 9 0.5625 0.0178217821782178
GO:CC GO:0005773 vacuole 8.42763193339961e-10 810 12 9 0.75 0.0111111111111111
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 1.98930638653904e-09 158 6 5 0.833333333333333 0.0316455696202532
GO:CC GO:0030666 endocytic vesicle membrane 1.98930638653904e-09 159 6 5 0.833333333333333 0.0314465408805031
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 2.36097857145982e-09 166 6 5 0.833333333333333 0.0301204819277108
GO:CC GO:0030662 coated vesicle membrane 3.12288614592905e-09 177 6 5 0.833333333333333 0.0282485875706215
GO:CC GO:0005768 endosome 3.87967970115272e-09 987 12 9 0.75 0.00911854103343465
GO:CC GO:0030136 clathrin-coated vesicle 4.44655865790672e-09 193 6 5 0.833333333333333 0.0259067357512953
GO:CC GO:0030658 transport vesicle membrane 6.38816724293241e-09 209 6 5 0.833333333333333 0.0239234449760766
GO:CC GO:0009986 cell surface 1.2824304077585e-08 899 40 14 0.35 0.0155728587319244
GO:CC GO:0005802 trans-Golgi network 1.46158143285466e-08 250 6 5 0.833333333333333 0.02
GO:CC GO:0030135 coated vesicle 3.24192781783652e-08 295 6 5 0.833333333333333 0.0169491525423729
GO:CC GO:0030139 endocytic vesicle 3.76616122720027e-08 306 6 5 0.833333333333333 0.0163398692810458
GO:CC GO:0098796 membrane protein complex 3.99956955540842e-08 1322 12 9 0.75 0.00680786686838124
GO:CC GO:0071944 cell periphery 4.13062707764302e-08 6169 20 19 0.95 0.00307991570757011
GO:CC GO:0005770 late endosome 4.13062707764302e-08 275 12 6 0.5 0.0218181818181818
GO:CC GO:0031410 cytoplasmic vesicle 4.65873568152696e-08 2424 13 11 0.846153846153846 0.00453795379537954
GO:CC GO:0097708 intracellular vesicle 4.65873568152696e-08 2428 13 11 0.846153846153846 0.00453047775947282
GO:CC GO:0031902 late endosome membrane 7.76111274754149e-08 140 12 5 0.416666666666667 0.0357142857142857
GO:CC GO:0016021 integral component of membrane 8.09911813353858e-08 5711 47 33 0.702127659574468 0.00577832253545789
GO:CC GO:0031301 integral component of organelle membrane 9.04319821209251e-08 382 6 5 0.833333333333333 0.0130890052356021
GO:CC GO:0030133 transport vesicle 1.28526970917161e-07 414 6 5 0.833333333333333 0.0120772946859903
GO:CC GO:0031300 intrinsic component of organelle membrane 1.28526970917161e-07 413 6 5 0.833333333333333 0.0121065375302663
GO:CC GO:0031224 intrinsic component of membrane 1.52986658596984e-07 5868 47 33 0.702127659574468 0.00562372188139059
GO:CC GO:0005886 plasma membrane 1.55621484186517e-07 5681 20 18 0.9 0.00316845625770111
GO:CC GO:0031982 vesicle 3.95140518784737e-07 4055 13 12 0.923076923076923 0.00295930949445129
GO:CC GO:0098552 side of membrane 4.49334214239727e-07 619 20 8 0.4 0.012924071082391
GO:CC GO:0098588 bounding membrane of organelle 9.81301245129715e-07 2158 7 7 1 0.00324374420759963
GO:CC GO:0000139 Golgi membrane 2.49146055325456e-06 771 6 5 0.833333333333333 0.00648508430609598
GO:CC GO:0030659 cytoplasmic vesicle membrane 2.56702064646882e-06 779 6 5 0.833333333333333 0.00641848523748395
GO:CC GO:0012506 vesicle membrane 2.86932836249483e-06 800 6 5 0.833333333333333 0.00625
GO:CC GO:0098791 Golgi apparatus subcompartment 4.64440547802965e-06 885 6 5 0.833333333333333 0.00564971751412429
GO:CC GO:0005789 endoplasmic reticulum membrane 1.44575779776672e-05 1117 6 5 0.833333333333333 0.0044762757385855
GO:CC GO:0098827 endoplasmic reticulum subcompartment 1.44914145015821e-05 1122 6 5 0.833333333333333 0.00445632798573975
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 1.53125807176562e-05 1139 6 5 0.833333333333333 0.00438981562774363
GO:CC GO:0012505 endomembrane system 2.98262092167834e-05 4640 13 11 0.846153846153846 0.00237068965517241
GO:CC GO:0005887 integral component of plasma membrane 2.98262092167834e-05 1645 43 14 0.325581395348837 0.00851063829787234
GO:CC GO:0031090 organelle membrane 2.98262092167834e-05 3612 7 7 1 0.00193798449612403
GO:CC GO:0005794 Golgi apparatus 3.01680014856002e-05 1623 8 6 0.75 0.00369685767097967
GO:CC GO:0031226 intrinsic component of plasma membrane 4.5370054609722e-05 1726 23 10 0.434782608695652 0.00579374275782155
GO:CC GO:0005783 endoplasmic reticulum 9.18340210388938e-05 1982 8 6 0.75 0.00302724520686176
GO:CC GO:0031984 organelle subcompartment 0.000118103039936776 1773 6 5 0.833333333333333 0.00282007896221094
GO:CC GO:0016020 membrane 0.000393182175845768 9838 47 37 0.787234042553192 0.00376092701768652
GO:CC GO:0032991 protein-containing complex 0.00053186843591089 5548 7 7 1 0.00126171593366979
GO:CC GO:0009897 external side of plasma membrane 0.000564951533584646 408 40 6 0.15 0.0147058823529412
GO:CC GO:0070062 extracellular exosome 0.000668313689839748 2176 13 7 0.538461538461538 0.00321691176470588
GO:CC GO:1903561 extracellular vesicle 0.00083065546973785 2261 13 7 0.538461538461538 0.00309597523219814
GO:CC GO:0043230 extracellular organelle 0.00083065546973785 2263 13 7 0.538461538461538 0.00309323906319046
GO:CC GO:0043202 lysosomal lumen 0.0015303030344867 97 32 3 0.09375 0.0309278350515464
GO:CC GO:0005615 extracellular space 0.00434175730348685 3594 20 10 0.5 0.00278241513633834
GO:CC GO:0034703 cation channel complex 0.00434175730348685 227 43 4 0.0930232558139535 0.0176211453744493
GO:CC GO:0005576 extracellular region 0.00507916223424214 4567 22 12 0.545454545454545 0.00262754543463981
GO:CC GO:0101002 ficolin-1-rich granule 0.00742316399260039 184 30 3 0.1 0.016304347826087
GO:CC GO:0005775 vacuolar lumen 0.00753715903519355 174 32 3 0.09375 0.0172413793103448
GO:CC GO:0034702 ion channel complex 0.0111684430110993 302 43 4 0.0930232558139535 0.0132450331125828
GO:CC GO:1902495 transmembrane transporter complex 0.0139064232682306 325 43 4 0.0930232558139535 0.0123076923076923
GO:CC GO:1990351 transporter complex 0.0160670725019253 340 43 4 0.0930232558139535 0.0117647058823529
GO:CC GO:0005769 early endosome 0.0278042829195896 378 46 4 0.0869565217391304 0.0105820105820106
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0331917048473954 11296 8 8 1 0.000708215297450425
GO:CC GO:0043227 membrane-bounded organelle 0.0425221061516502 12858 10 10 1 0.000777725929382486
GO:CC GO:0005737 cytoplasm 0.0484762968809314 11911 8 8 1 0.000671648056418437
GO:MF GO:0023026 MHC class II protein complex binding 1.91486360681911e-11 17 10 5 0.5 0.294117647058824
GO:MF GO:0023023 MHC protein complex binding 8.2058099179842e-11 25 10 5 0.5 0.2
GO:MF GO:0042605 peptide antigen binding 4.20029493864811e-10 30 4 4 1 0.133333333333333
GO:MF GO:0042277 peptide binding 7.96469885396328e-10 314 20 9 0.45 0.0286624203821656
GO:MF GO:0003823 antigen binding 2.37845265061499e-09 163 40 9 0.225 0.0552147239263804
GO:MF GO:0033218 amide binding 3.58491478386007e-09 389 20 9 0.45 0.0231362467866324
GO:MF GO:0032395 MHC class II receptor activity 6.86733278890917e-09 8 4 3 0.75 0.375
GO:MF GO:0140375 immune receptor activity 3.53767552261164e-07 133 40 7 0.175 0.0526315789473684
GO:MF GO:0030246 carbohydrate binding 8.28399879197441e-05 275 45 7 0.155555555555556 0.0254545454545455
GO:MF GO:0019955 cytokine binding 0.00217837217206576 138 39 4 0.102564102564103 0.0289855072463768
GO:MF GO:0044877 protein-containing complex binding 0.00217837217206576 1287 14 6 0.428571428571429 0.00466200466200466
GO:MF GO:0004888 transmembrane signaling receptor activity 0.00301632277356849 1269 6 4 0.666666666666667 0.00315208825847124
GO:MF GO:0038023 signaling receptor activity 0.0045494863697704 1458 6 4 0.666666666666667 0.00274348422496571
GO:MF GO:0060089 molecular transducer activity 0.0045494863697704 1458 6 4 0.666666666666667 0.00274348422496571
GO:MF GO:0004896 cytokine receptor activity 0.00946447958286538 99 39 3 0.0769230769230769 0.0303030303030303
GO:MF GO:0005261 cation channel activity 0.0338247495337399 340 43 4 0.0930232558139535 0.0117647058823529
GO:MF GO:0022836 gated channel activity 0.0338247495337399 341 43 4 0.0930232558139535 0.0117302052785924
GO:MF GO:0022832 voltage-gated channel activity 0.0387873616375037 201 43 3 0.0697674418604651 0.0149253731343284
GO:MF GO:0005102 signaling receptor binding 0.0387873616375037 1672 6 3 0.5 0.00179425837320574
GO:MF GO:0005244 voltage-gated ion channel activity 0.0387873616375037 200 43 3 0.0697674418604651 0.015
HP HP:0011227 Elevated C-reactive protein level 0.000202714674131022 51 3 3 1 0.0588235294117647
HP HP:0003565 Elevated erythrocyte sedimentation rate 0.000202714674131022 48 3 3 1 0.0625
HP HP:0002113 Pulmonary infiltrates 0.000202714674131022 53 3 3 1 0.0566037735849057
HP HP:0001701 Pericarditis 0.000202714674131022 34 3 3 1 0.0882352941176471
HP HP:0025021 Abnormal erythrocyte sedimentation rate 0.000202714674131022 49 3 3 1 0.0612244897959184
HP HP:0032436 Abnormal C-reactive protein level 0.000202714674131022 52 3 3 1 0.0576923076923077
HP HP:0100749 Chest pain 0.000202714674131022 93 5 4 0.8 0.043010752688172
HP HP:0045073 Serositis 0.000202714674131022 40 3 3 1 0.075
HP HP:0000873 Diabetes insipidus 0.000225050844064728 57 3 3 1 0.0526315789473684
HP HP:0002105 Hemoptysis 0.000225050844064728 59 3 3 1 0.0508474576271186
HP HP:0012735 Cough 0.000258044548048625 128 5 4 0.8 0.03125
HP HP:0001697 Abnormal pericardium morphology 0.000258044548048625 68 3 3 1 0.0441176470588235
HP HP:0033331 Acute phase response 0.000258044548048625 65 3 3 1 0.0461538461538462
HP HP:0001287 Meningitis 0.000258044548048625 72 3 3 1 0.0416666666666667
HP HP:0031983 Abnormal pulmonary thoracic imaging finding 0.000258044548048625 71 3 3 1 0.0422535211267606
HP HP:0002206 Pulmonary fibrosis 0.000258044548048625 69 3 3 1 0.0434782608695652
HP HP:0002103 Abnormal pleura morphology 0.000329812430801679 84 3 3 1 0.0357142857142857
HP HP:0002091 Restrictive ventilatory defect 0.000329812430801679 80 3 3 1 0.0375
HP HP:0011450 Unusual CNS infection 0.000349416267387358 87 3 3 1 0.0344827586206897
HP HP:0011122 Abnormality of skin physiology 0.000362070018435677 430 5 5 1 0.0116279069767442
HP HP:0032158 Unusual infection by anatomical site 0.000362070018435677 91 3 3 1 0.032967032967033
HP HP:0002960 Autoimmunity 0.000402350261350892 170 5 4 0.8 0.0235294117647059
HP HP:0000763 Sensory neuropathy 0.000494641470646504 182 5 4 0.8 0.021978021978022
HP HP:0032016 Abnormal sputum 0.000494641470646504 106 3 3 1 0.0283018867924528
HP HP:0200042 Skin ulcer 0.000569751747247447 115 3 3 1 0.0260869565217391
HP HP:0000988 Skin rash 0.000569751747247447 114 3 3 1 0.0263157894736842
HP HP:0030878 Abnormality on pulmonary function testing 0.000762339331772549 128 3 3 1 0.0234375
HP HP:0006530 Abnormal pulmonary Interstitial morphology 0.000968272793558044 140 3 3 1 0.0214285714285714
HP HP:0002829 Arthralgia 0.00143203894299058 161 3 3 1 0.0186335403726708
HP HP:0001824 Weight loss 0.00194379539519596 273 5 4 0.8 0.0146520146520147
HP HP:0100533 Inflammatory abnormality of the eye 0.00220706928120743 193 3 3 1 0.0155440414507772
HP HP:0012575 Abnormal nephron morphology 0.00262398941629379 208 3 3 1 0.0144230769230769
HP HP:0030163 Abnormal vascular physiology 0.00369923284527551 248 3 3 1 0.0120967741935484
HP HP:0002027 Abdominal pain 0.00375575820862466 251 3 3 1 0.0119521912350598
HP HP:0011123 Inflammatory abnormality of the skin 0.00417691756184559 367 5 4 0.8 0.0108991825613079
HP HP:0006824 Cranial nerve paralysis 0.00495910739325898 287 3 3 1 0.0104529616724739
HP HP:0031910 Abnormal cranial nerve physiology 0.00495910739325898 288 3 3 1 0.0104166666666667
HP HP:0001945 Fever 0.00518245524714746 294 3 3 1 0.0102040816326531
HP HP:0000822 Hypertension 0.00564407324521147 306 3 3 1 0.00980392156862745
HP HP:0001426 Multifactorial inheritance 0.00578430535937014 84 8 3 0.375 0.0357142857142857
HP HP:0010974 Abnormal myeloid leukocyte morphology 0.00578430535937014 312 3 3 1 0.00961538461538462
HP HP:0012378 Fatigue 0.00682371285364852 335 3 3 1 0.00895522388059702
HP HP:0000083 Renal insufficiency 0.00683848339247641 337 3 3 1 0.00890207715133531
HP HP:0032263 Increased blood pressure 0.00733884408480937 350 3 3 1 0.00857142857142857
HP HP:0010876 Abnormal circulating protein concentration 0.00868211255028474 480 5 4 0.8 0.00833333333333333
HP HP:0011675 Arrhythmia 0.00868211255028474 381 3 3 1 0.0078740157480315
HP HP:0011276 Vascular skin abnormality 0.00913332738849345 493 5 4 0.8 0.00811359026369168
HP HP:0004370 Abnormality of temperature regulation 0.00937570264075217 398 3 3 1 0.00753768844221105
HP HP:0011799 Abnormality of facial soft tissue 0.0103447564913126 413 3 3 1 0.00726392251815981
HP HP:0030972 Abnormal systemic blood pressure 0.010424950025361 423 3 3 1 0.00709219858156028
HP HP:0004374 Hemiplegia/hemiparesis 0.010424950025361 199 5 3 0.6 0.0150753768844221
HP HP:0030956 Abnormality of cardiovascular system electrophysiology 0.010424950025361 424 3 3 1 0.00707547169811321
HP HP:0002017 Nausea and vomiting 0.0111185797098109 442 3 3 1 0.00678733031674208
HP HP:0000969 Edema 0.0139672914194894 489 3 3 1 0.00613496932515337
HP HP:0009830 Peripheral neuropathy 0.0140526931269379 588 5 4 0.8 0.00680272108843537
HP HP:0001881 Abnormal leukocyte morphology 0.0147720317103461 510 3 3 1 0.00588235294117647
HP HP:0010987 Abnormal cellular immune system morphology 0.0147720317103461 510 3 3 1 0.00588235294117647
HP HP:0032251 Abnormal immune system morphology 0.016451992738525 532 3 3 1 0.0056390977443609
HP HP:0012531 Pain 0.0172050428412379 636 5 4 0.8 0.00628930817610063
HP HP:0011032 Abnormality of fluid regulation 0.0186890183797198 562 3 3 1 0.00533807829181495
HP HP:0003110 Abnormality of urine homeostasis 0.0205524064722824 586 3 3 1 0.00511945392491468
HP HP:0012211 Abnormal renal physiology 0.0224670175672389 614 3 3 1 0.00488599348534202
HP HP:0002719 Recurrent infections 0.0256412685743335 745 5 4 0.8 0.00536912751677852
HP HP:0032101 Unusual infection 0.0297639898231512 792 5 4 0.8 0.00505050505050505
HP HP:0011355 Localized skin lesion 0.030743412852609 805 5 4 0.8 0.00496894409937888
HP HP:0002242 Abnormal intestine morphology 0.0308841768234911 742 3 3 1 0.00404312668463612
HP HP:0000759 Abnormal peripheral nervous system morphology 0.0350124809715562 845 5 4 0.8 0.00473372781065089
HP HP:0011354 Generalized abnormality of skin 0.0380309007947449 876 5 4 0.8 0.0045662100456621
HP HP:0012649 Increased inflammatory response 0.0426783290886783 914 5 4 0.8 0.00437636761487965
HP HP:0012647 Abnormal inflammatory response 0.0426783290886783 914 5 4 0.8 0.00437636761487965
HP HP:0012719 Functional abnormality of the gastrointestinal tract 0.0429691912954082 917 5 4 0.8 0.00436205016357688
HP HP:0000479 Abnormal retinal morphology 0.0438191825432244 877 3 3 1 0.00342075256556442
HP HP:0025142 Constitutional symptom 0.0456207905464566 939 5 4 0.8 0.00425985090521832
HP HP:0012210 Abnormal renal morphology 0.0464376099978063 909 3 3 1 0.0033003300330033
HP HP:0002088 Abnormal lung morphology 0.0474406425804562 960 5 4 0.8 0.00416666666666667
HP HP:0011277 Abnormality of the urinary system physiology 0.0474406425804562 922 3 3 1 0.00325379609544469
HP HP:0011121 Abnormality of skin morphology 0.0476122651018184 1740 5 5 1 0.0028735632183908
HP HP:0010549 Weakness due to upper motor neuron dysfunction 0.0490314498014545 459 5 3 0.6 0.0065359477124183
HP HP:0025033 Abnormality of digestive system morphology 0.0491756426462527 943 3 3 1 0.0031813361611877
HP HP:0012718 Morphological abnormality of the gastrointestinal tract 0.0491756426462527 943 3 3 1 0.0031813361611877
HPA HPA:0310433 lymph node; germinal center cells[High] 0.00557360939200451 908 10 6 0.6 0.0066079295154185
HPA HPA:0530712 spleen; cells in red pulp[≥Medium] 0.00557360939200451 3049 13 11 0.846153846153846 0.00360774024270253
HPA HPA:0310442 lymph node; non-germinal center cells[≥Medium] 0.00557360939200451 3875 15 13 0.866666666666667 0.00335483870967742
HPA HPA:0530711 spleen; cells in red pulp[≥Low] 0.00557360939200451 5195 15 15 1 0.00288739172281039
HPA HPA:0530000 spleen 0.00557360939200451 5756 15 15 1 0.00260597637248089
HPA HPA:0310443 lymph node; non-germinal center cells[High] 0.00768801541318618 1169 4 4 1 0.00342172797262618
HPA HPA:0600433 tonsil; germinal center cells[High] 0.0113172589468592 1179 7 5 0.714285714285714 0.00424088210347752
HPA HPA:0300412 lung; macrophages[≥Medium] 0.0113172589468592 4732 10 10 1 0.00211327134404058
HPA HPA:0300413 lung; macrophages[High] 0.0120429653427447 1224 7 5 0.714285714285714 0.00408496732026144
HPA HPA:0600443 tonsil; non-germinal center cells[High] 0.0129848774008781 1271 7 5 0.714285714285714 0.003933910306845
HPA HPA:0600432 tonsil; germinal center cells[≥Medium] 0.0245339734679147 3988 7 7 1 0.00175526579739218
HPA HPA:0600441 tonsil; non-germinal center cells[≥Low] 0.0245339734679147 5966 12 12 1 0.00201139792155548
HPA HPA:0211092 fallopian tube; non-ciliated cells[≥Medium] 0.0245339734679147 328 7 3 0.428571428571429 0.00914634146341463
HPA HPA:0600442 tonsil; non-germinal center cells[≥Medium] 0.0261840365078429 4079 15 12 0.8 0.00294189752390292
HPA HPA:0530722 spleen; cells in white pulp[≥Medium] 0.0269503097547156 2645 7 6 0.857142857142857 0.00226843100189036
HPA HPA:0530721 spleen; cells in white pulp[≥Low] 0.0310779923346121 4249 7 7 1 0.00164744645799012
HPA HPA:0310441 lymph node; non-germinal center cells[≥Low] 0.0328344657588679 5915 15 14 0.933333333333333 0.00236686390532544
HPA HPA:0211091 fallopian tube; non-ciliated cells[≥Low] 0.0407544897847735 456 7 3 0.428571428571429 0.00657894736842105
HPA HPA:0460643 skin 1; Langerhans[High] 0.0473513200897613 734 5 3 0.6 0.00408719346049046
KEGG KEGG:05310 Asthma 1.76381609242217e-18 27 14 9 0.642857142857143 0.333333333333333
KEGG KEGG:05330 Allograft rejection 7.49124863572189e-16 34 12 8 0.666666666666667 0.235294117647059
KEGG KEGG:04612 Antigen processing and presentation 7.73311398665462e-16 69 12 9 0.75 0.130434782608696
KEGG KEGG:05332 Graft-versus-host disease 7.95417819478972e-16 37 12 8 0.666666666666667 0.216216216216216
KEGG KEGG:04940 Type I diabetes mellitus 1.26584056324339e-15 40 12 8 0.666666666666667 0.2
KEGG KEGG:04672 Intestinal immune network for IgA production 2.95005247493363e-15 45 12 8 0.666666666666667 0.177777777777778
KEGG KEGG:05320 Autoimmune thyroid disease 5.28089802683314e-15 49 12 8 0.666666666666667 0.163265306122449
KEGG KEGG:05321 Inflammatory bowel disease 1.11588358001547e-14 62 17 9 0.529411764705882 0.145161290322581
KEGG KEGG:05416 Viral myocarditis 1.28969880069931e-14 56 12 8 0.666666666666667 0.142857142857143
KEGG KEGG:04640 Hematopoietic cell lineage 3.65927038578556e-14 95 20 10 0.5 0.105263157894737
KEGG KEGG:05140 Leishmaniasis 3.65927038578556e-14 72 17 9 0.529411764705882 0.125
KEGG KEGG:04658 Th1 and Th2 cell differentiation 2.27446324705397e-13 89 17 9 0.529411764705882 0.101123595505618
KEGG KEGG:05145 Toxoplasmosis 2.42653778708939e-13 109 21 10 0.476190476190476 0.0917431192660551
KEGG KEGG:05150 Staphylococcus aureus infection 3.36352634141659e-13 87 12 8 0.666666666666667 0.0919540229885057
KEGG KEGG:05323 Rheumatoid arthritis 3.45167117451618e-13 88 12 8 0.666666666666667 0.0909090909090909
KEGG KEGG:05152 Tuberculosis 5.11010620340232e-13 175 21 11 0.523809523809524 0.0628571428571429
KEGG KEGG:04659 Th17 cell differentiation 6.84568078208758e-13 104 17 9 0.529411764705882 0.0865384615384615
KEGG KEGG:05322 Systemic lupus erythematosus 8.07885086120386e-12 132 12 8 0.666666666666667 0.0606060606060606
KEGG KEGG:05164 Influenza A 1.44072374504787e-11 169 21 10 0.476190476190476 0.0591715976331361
KEGG KEGG:04514 Cell adhesion molecules 1.65289662874275e-11 146 12 8 0.666666666666667 0.0547945205479452
KEGG KEGG:04145 Phagosome 1.66403632353842e-11 147 12 8 0.666666666666667 0.054421768707483
KEGG KEGG:05169 Epstein-Barr virus infection 1.76877311979145e-10 198 12 8 0.666666666666667 0.0404040404040404
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 3.40696063194483e-10 216 12 8 0.666666666666667 0.037037037037037
KEGG KEGG:05168 Herpes simplex virus 1 infection 6.59986461420742e-09 494 12 9 0.75 0.0182186234817814
REAC REAC:R-HSA-2132295 MHC class II antigen presentation 1.45422041210661e-11 123 12 8 0.666666666666667 0.0650406504065041
REAC REAC:R-HSA-202430 Translocation of ZAP-70 to Immunological synapse 5.27331127151611e-10 20 4 4 1 0.2
REAC REAC:R-HSA-389948 PD-1 signaling 5.78268375347059e-10 24 4 4 1 0.166666666666667
REAC REAC:R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 5.78268375347059e-10 23 4 4 1 0.173913043478261
REAC REAC:R-HSA-202433 Generation of second messenger molecules 2.27955069702028e-09 35 4 4 1 0.114285714285714
REAC REAC:R-HSA-877300 Interferon gamma signaling 4.02954451431355e-09 87 21 7 0.333333333333333 0.0804597701149425
REAC REAC:R-HSA-388841 Costimulation by the CD28 family 2.38353980444739e-08 67 4 4 1 0.0597014925373134
REAC REAC:R-HSA-202424 Downstream TCR signaling 9.82903861706509e-08 98 4 4 1 0.0408163265306122
REAC REAC:R-HSA-202403 TCR signaling 1.98683566433473e-07 120 4 4 1 0.0333333333333333
REAC REAC:R-HSA-913531 Interferon Signaling 6.0290075355755e-07 191 21 7 0.333333333333333 0.0366492146596859
REAC REAC:R-HSA-168256 Immune System 7.16781977453126e-07 2139 17 14 0.823529411764706 0.00654511453950444
REAC REAC:R-HSA-1280218 Adaptive Immune System 3.72871348018067e-06 800 12 8 0.666666666666667 0.01
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.000348188450968907 842 4 4 1 0.00475059382422803
TF TF:M09920 Factor: Fli-1; motif: NNRGGMAGGAAGGRRRGR 0.0409865040370222 9289 46 36 0.782608695652174 0.00387555172785015
TF TF:M09726_1 Factor: GATAD2A; motif: CCTKTG; match class: 1 0.0409865040370222 9052 15 15 1 0.0016570923552806
WP WP:WP4217 Ebola Virus Pathway on Host 8.99581322546475e-13 130 12 9 0.75 0.0692307692307692
WP WP:WP2328 Allograft Rejection 2.50038399573493e-12 88 12 8 0.666666666666667 0.0909090909090909
WP WP:WP4884 Pathogenesis of SARS-CoV-2 Mediated by nsp9-nsp10 Complex 5.81808956006384e-05 21 12 3 0.25 0.142857142857143

pM22 transcription factor target enrichment of top program genes

TF enrichment of pM22
TFs corrosponding to activation of pM22. (Left) pearson correlation of TF expression and gene expression program activatity in Myeloid cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.