pTNI19 program activity among T/NK/ILC cells

Activation of pTNI19
pTNI19 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI19 by different cell subtypes
pTNI19 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI19 top program genes

Top genes of pTNI19 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI19 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI19
pTNI19 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:7385 DTX3L-PARP9-STAT1 complex 0.000279184998714635 3 80 3 0.0375 1
CORUM CORUM:60 Interferon-stimulated gene factor 3 transcription complex ISGF3 0.000279184998714635 3 77 3 0.038961038961039 1
GO:BP GO:0009615 response to virus 2.34607589420168e-46 364 94 44 0.468085106382979 0.120879120879121
GO:BP GO:0140546 defense response to symbiont 7.1889016273279e-46 267 94 40 0.425531914893617 0.149812734082397
GO:BP GO:0051607 defense response to virus 7.1889016273279e-46 267 94 40 0.425531914893617 0.149812734082397
GO:BP GO:0060337 type I interferon signaling pathway 7.39896920135193e-43 95 102 30 0.294117647058824 0.315789473684211
GO:BP GO:0071357 cellular response to type I interferon 8.5764349944819e-43 96 102 30 0.294117647058824 0.3125
GO:BP GO:0034340 response to type I interferon 3.81485096662092e-42 101 77 28 0.363636363636364 0.277227722772277
GO:BP GO:0045087 innate immune response 4.20351833871767e-42 998 129 63 0.488372093023256 0.06312625250501
GO:BP GO:0098542 defense response to other organism 1.32865060257455e-41 1218 129 67 0.51937984496124 0.055008210180624
GO:BP GO:0043207 response to external biotic stimulus 5.49429927772341e-39 1594 139 74 0.532374100719424 0.0464240903387704
GO:BP GO:0051707 response to other organism 5.49429927772341e-39 1592 139 74 0.532374100719424 0.0464824120603015
GO:BP GO:0009607 response to biotic stimulus 1.98737380151803e-38 1626 139 74 0.532374100719424 0.045510455104551
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 1.32394734553202e-37 2255 139 83 0.597122302158273 0.0368070953436807
GO:BP GO:0006952 defense response 4.96998442128009e-36 1818 129 72 0.558139534883721 0.0396039603960396
GO:BP GO:0034097 response to cytokine 9.84569742332609e-35 1226 129 61 0.472868217054264 0.0497553017944535
GO:BP GO:0006955 immune response 1.79172762445863e-34 2311 131 78 0.595419847328244 0.033751622674167
GO:BP GO:0019221 cytokine-mediated signaling pathway 7.18216290741329e-30 810 64 36 0.5625 0.0444444444444444
GO:BP GO:0071345 cellular response to cytokine stimulus 2.73116916882011e-29 1132 78 43 0.551282051282051 0.0379858657243816
GO:BP GO:0048525 negative regulation of viral process 4.54657168471949e-29 94 129 24 0.186046511627907 0.25531914893617
GO:BP GO:0050792 regulation of viral process 2.17074094391332e-28 192 129 29 0.224806201550388 0.151041666666667
GO:BP GO:0002376 immune system process 2.65812920009692e-28 3278 139 86 0.618705035971223 0.026235509456986
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 1.05712914667633e-27 203 129 29 0.224806201550388 0.142857142857143
GO:BP GO:0034341 response to interferon-gamma 3.63296457094279e-27 196 139 29 0.20863309352518 0.147959183673469
GO:BP GO:1903900 regulation of viral life cycle 9.84067783439897e-27 153 129 26 0.201550387596899 0.169934640522876
GO:BP GO:0045071 negative regulation of viral genome replication 2.72516848518299e-26 54 76 17 0.223684210526316 0.314814814814815
GO:BP GO:0002252 immune effector process 8.9809576237955e-26 1309 94 46 0.48936170212766 0.0351413292589763
GO:BP GO:0016032 viral process 1.16521445567888e-24 942 129 46 0.356589147286822 0.0488322717622081
GO:BP GO:0045069 regulation of viral genome replication 1.41152524115968e-24 84 76 18 0.236842105263158 0.214285714285714
GO:BP GO:0044403 biological process involved in symbiotic interaction 1.41152524115968e-24 1001 129 47 0.364341085271318 0.046953046953047
GO:BP GO:0009605 response to external stimulus 3.60485578127533e-24 2944 94 61 0.648936170212766 0.0207201086956522
GO:BP GO:0019079 viral genome replication 1.36393208828747e-22 131 76 19 0.25 0.145038167938931
GO:BP GO:0071346 cellular response to interferon-gamma 2.40550393392096e-22 175 129 24 0.186046511627907 0.137142857142857
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 2.04065622031826e-21 88 129 19 0.147286821705426 0.215909090909091
GO:BP GO:0019058 viral life cycle 4.7328108090553e-21 353 116 28 0.241379310344828 0.0793201133144476
GO:BP GO:0006950 response to stress 1.80947237995344e-19 4170 94 65 0.691489361702128 0.0155875299760192
GO:BP GO:0002831 regulation of response to biotic stimulus 3.66715824735276e-18 415 137 29 0.211678832116788 0.0698795180722892
GO:BP GO:0071310 cellular response to organic substance 6.95912465625189e-18 2776 92 52 0.565217391304348 0.0187319884726225
GO:BP GO:0010033 response to organic substance 1.29800151408031e-17 3412 93 57 0.612903225806452 0.0167057444314185
GO:BP GO:0035455 response to interferon-alpha 8.49181173362001e-16 23 96 10 0.104166666666667 0.434782608695652
GO:BP GO:0045088 regulation of innate immune response 8.9408120617427e-15 309 137 23 0.167883211678832 0.0744336569579288
GO:BP GO:0070887 cellular response to chemical stimulus 4.70189350637717e-14 3393 92 52 0.565217391304348 0.0153256704980843
GO:BP GO:0031347 regulation of defense response 7.21477197146098e-14 704 137 31 0.226277372262774 0.0440340909090909
GO:BP GO:0007166 cell surface receptor signaling pathway 1.30013352196381e-13 3210 64 40 0.625 0.0124610591900312
GO:BP GO:0032479 regulation of type I interferon production 2.58427312239034e-12 130 134 15 0.111940298507463 0.115384615384615
GO:BP GO:0032606 type I interferon production 2.83448666599452e-12 131 134 15 0.111940298507463 0.114503816793893
GO:BP GO:0042221 response to chemical 4.03161158750058e-12 4781 93 59 0.634408602150538 0.0123405145367078
GO:BP GO:0002682 regulation of immune system process 1.14360239828125e-11 1617 129 41 0.317829457364341 0.0253555967841682
GO:BP GO:0032101 regulation of response to external stimulus 1.50672131821426e-11 1051 129 33 0.255813953488372 0.0313986679352997
GO:BP GO:0035456 response to interferon-beta 2.55452618255555e-11 30 78 8 0.102564102564103 0.266666666666667
GO:BP GO:0000209 protein polyubiquitination 2.35281750065651e-10 342 129 19 0.147286821705426 0.0555555555555556
GO:BP GO:0002833 positive regulation of response to biotic stimulus 3.70105895376591e-10 250 137 17 0.124087591240876 0.068
GO:BP GO:0050776 regulation of immune response 5.88869766634003e-10 996 137 31 0.226277372262774 0.0311244979919679
GO:BP GO:0032480 negative regulation of type I interferon production 2.35089749964886e-09 46 134 9 0.0671641791044776 0.195652173913043
GO:BP GO:0001817 regulation of cytokine production 2.9866712562094e-09 806 137 27 0.197080291970803 0.0334987593052109
GO:BP GO:0045089 positive regulation of innate immune response 4.20774748100585e-09 216 75 12 0.16 0.0555555555555556
GO:BP GO:0001816 cytokine production 8.079943671204e-09 844 137 27 0.197080291970803 0.0319905213270142
GO:BP GO:0032103 positive regulation of response to external stimulus 1.4087041070059e-08 513 137 21 0.153284671532847 0.0409356725146199
GO:BP GO:0080134 regulation of response to stress 2.92351424409307e-08 1443 139 35 0.251798561151079 0.0242550242550243
GO:BP GO:0046596 regulation of viral entry into host cell 2.98186514106524e-08 43 129 8 0.062015503875969 0.186046511627907
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 3.38530535215221e-08 185 129 13 0.10077519379845 0.0702702702702703
GO:BP GO:0050896 response to stimulus 5.48769593896735e-08 9407 94 77 0.819148936170213 0.00818539385563942
GO:BP GO:0016567 protein ubiquitination 7.33508998262758e-08 892 134 26 0.194029850746269 0.0291479820627803
GO:BP GO:0032446 protein modification by small protein conjugation 9.63193489225309e-08 973 134 27 0.201492537313433 0.0277492291880781
GO:BP GO:0052372 modulation by symbiont of entry into host 9.74914814354617e-08 50 129 8 0.062015503875969 0.16
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 1.06883916819852e-07 291 129 15 0.116279069767442 0.0515463917525773
GO:BP GO:0060759 regulation of response to cytokine stimulus 1.10348488869453e-07 197 87 11 0.126436781609195 0.0558375634517767
GO:BP GO:0050688 regulation of defense response to virus 1.30374029048106e-07 71 137 9 0.0656934306569343 0.126760563380282
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 1.30881798797638e-07 251 129 14 0.108527131782946 0.0557768924302789
GO:BP GO:0098586 cellular response to virus 1.44052392247854e-07 72 94 8 0.0851063829787234 0.111111111111111
GO:BP GO:0048584 positive regulation of response to stimulus 2.16422319230946e-07 2344 138 44 0.318840579710145 0.0187713310580205
GO:BP GO:0002684 positive regulation of immune system process 2.26665616269694e-07 1065 137 28 0.204379562043796 0.0262910798122066
GO:BP GO:0051701 biological process involved in interaction with host 2.45785689156143e-07 221 129 13 0.10077519379845 0.0588235294117647
GO:BP GO:0051716 cellular response to stimulus 2.64978775124072e-07 7781 94 68 0.723404255319149 0.00873923660197918
GO:BP GO:0007165 signal transduction 2.64978775124072e-07 6309 62 44 0.709677419354839 0.00697416389285148
GO:BP GO:0060700 regulation of ribonuclease activity 2.81545656952184e-07 9 52 4 0.0769230769230769 0.444444444444444
GO:BP GO:0070647 protein modification by small protein conjugation or removal 3.03792835032135e-07 1184 134 29 0.216417910447761 0.0244932432432432
GO:BP GO:0032481 positive regulation of type I interferon production 3.03792835032135e-07 80 94 8 0.0851063829787234 0.1
GO:BP GO:0045824 negative regulation of innate immune response 3.13356472295259e-07 66 115 8 0.0695652173913043 0.121212121212121
GO:BP GO:0060760 positive regulation of response to cytokine stimulus 3.56079912825296e-07 57 87 7 0.0804597701149425 0.12280701754386
GO:BP GO:0050778 positive regulation of immune response 3.68751169684896e-07 753 137 23 0.167883211678832 0.0305444887118194
GO:BP GO:0038061 NIK/NF-kappaB signaling 4.91250267909127e-07 194 60 9 0.15 0.0463917525773196
GO:BP GO:0031349 positive regulation of defense response 5.23638566743194e-07 362 137 16 0.116788321167883 0.0441988950276243
GO:BP GO:0023052 signaling 6.47677444684431e-07 6810 88 59 0.670454545454545 0.00866372980910426
GO:BP GO:0140289 protein mono-ADP-ribosylation 6.97026103917217e-07 12 142 5 0.0352112676056338 0.416666666666667
GO:BP GO:1903901 negative regulation of viral life cycle 7.83133118376125e-07 26 129 6 0.0465116279069767 0.230769230769231
GO:BP GO:0048519 negative regulation of biological process 8.77255621266251e-07 5757 64 42 0.65625 0.00729546638874414
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 1.34361507553204e-06 162 137 11 0.0802919708029197 0.0679012345679012
GO:BP GO:0032020 ISG15-protein conjugation 1.35098663833845e-06 6 134 4 0.0298507462686567 0.666666666666667
GO:BP GO:0009967 positive regulation of signal transduction 1.72813741704813e-06 1598 129 32 0.248062015503876 0.0200250312891114
GO:BP GO:0052126 movement in host environment 1.73051447917695e-06 177 129 11 0.0852713178294574 0.0621468926553672
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 1.73930751785252e-06 75 128 8 0.0625 0.106666666666667
GO:BP GO:0046718 viral entry into host cell 2.01327619501205e-06 141 129 10 0.0775193798449612 0.0709219858156028
GO:BP GO:0007154 cell communication 2.16849070989333e-06 6829 88 58 0.659090909090909 0.00849319080392444
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 2.80802518707811e-06 80 128 8 0.0625 0.1
GO:BP GO:0001819 positive regulation of cytokine production 3.21193928020537e-06 452 111 15 0.135135135135135 0.0331858407079646
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 4.0206012671294e-06 270 137 13 0.0948905109489051 0.0481481481481481
GO:BP GO:0039530 MDA-5 signaling pathway 4.0206012671294e-06 10 94 4 0.0425531914893617 0.4
GO:BP GO:0044409 entry into host 4.34110673128313e-06 154 129 10 0.0775193798449612 0.0649350649350649
GO:BP GO:0002230 positive regulation of defense response to virus by host 4.38868122070442e-06 33 137 6 0.0437956204379562 0.181818181818182
GO:BP GO:0002221 pattern recognition receptor signaling pathway 4.38868122070442e-06 213 94 10 0.106382978723404 0.0469483568075117
GO:BP GO:0010647 positive regulation of cell communication 5.2949871729491e-06 1777 129 33 0.255813953488372 0.0185706246482836
GO:BP GO:0023056 positive regulation of signaling 5.59701050062705e-06 1782 129 33 0.255813953488372 0.0185185185185185
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 6.02522722335346e-06 184 86 9 0.104651162790698 0.0489130434782609
GO:BP GO:0002832 negative regulation of response to biotic stimulus 6.34717892834938e-06 100 115 8 0.0695652173913043 0.08
GO:BP GO:0046597 negative regulation of viral entry into host cell 6.41712495375851e-06 20 129 5 0.0387596899224806 0.25
GO:BP GO:0032647 regulation of interferon-alpha production 7.70192839806553e-06 30 87 5 0.0574712643678161 0.166666666666667
GO:BP GO:0032607 interferon-alpha production 7.70192839806553e-06 30 87 5 0.0574712643678161 0.166666666666667
GO:BP GO:0070555 response to interleukin-1 9.52476098230954e-06 215 128 11 0.0859375 0.0511627906976744
GO:BP GO:0032069 regulation of nuclease activity 1.08949248288649e-05 22 52 4 0.0769230769230769 0.181818181818182
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 1.26507124601697e-05 99 128 8 0.0625 0.0808080808080808
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 1.35211968050061e-05 673 134 19 0.141791044776119 0.0282317979197623
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 1.60116112185516e-05 750 134 20 0.149253731343284 0.0266666666666667
GO:BP GO:0048583 regulation of response to stimulus 1.73199164431178e-05 4278 94 44 0.468085106382979 0.0102851799906498
GO:BP GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 1.75148639834752e-05 33 94 5 0.0531914893617021 0.151515151515152
GO:BP GO:0050691 regulation of defense response to virus by host 1.97166857528737e-05 43 137 6 0.0437956204379562 0.13953488372093
GO:BP GO:0044265 cellular macromolecule catabolic process 2.41795326633601e-05 1231 134 26 0.194029850746269 0.0211210398050366
GO:BP GO:0010629 negative regulation of gene expression 2.60640403848181e-05 1460 94 23 0.24468085106383 0.0157534246575342
GO:BP GO:0002218 activation of innate immune response 3.52614456820954e-05 144 137 9 0.0656934306569343 0.0625
GO:BP GO:0019941 modification-dependent protein catabolic process 4.40433255207046e-05 662 134 18 0.134328358208955 0.027190332326284
GO:BP GO:0044257 cellular protein catabolic process 5.1798635942379e-05 813 134 20 0.149253731343284 0.02460024600246
GO:BP GO:0051336 regulation of hydrolase activity 6.54503807450882e-05 1321 72 18 0.25 0.0136260408781226
GO:BP GO:0046719 regulation by virus of viral protein levels in host cell 6.68633077967495e-05 8 69 3 0.0434782608695652 0.375
GO:BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 6.77943526055079e-05 68 60 5 0.0833333333333333 0.0735294117647059
GO:BP GO:0023051 regulation of signaling 7.00324488338987e-05 3578 64 29 0.453125 0.00810508664058133
GO:BP GO:1902187 negative regulation of viral release from host cell 7.0394766774637e-05 15 129 4 0.0310077519379845 0.266666666666667
GO:BP GO:0009966 regulation of signal transduction 7.05162777663944e-05 3165 64 27 0.421875 0.00853080568720379
GO:BP GO:0052548 regulation of endopeptidase activity 7.34218419663312e-05 437 96 12 0.125 0.0274599542334096
GO:BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 8.37110677647583e-05 50 86 5 0.0581395348837209 0.1
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 8.76037176484597e-05 174 128 9 0.0703125 0.0517241379310345
GO:BP GO:1902036 regulation of hematopoietic stem cell differentiation 8.80660106429425e-05 75 58 5 0.0862068965517241 0.0666666666666667
GO:BP GO:0001818 negative regulation of cytokine production 9.50404490661295e-05 381 94 11 0.117021276595745 0.0288713910761155
GO:BP GO:0002697 regulation of immune effector process 9.75371474483502e-05 461 94 12 0.127659574468085 0.0260303687635575
GO:BP GO:0032727 positive regulation of interferon-alpha production 0.000102577625003689 24 87 4 0.0459770114942529 0.166666666666667
GO:BP GO:0060338 regulation of type I interferon-mediated signaling pathway 0.000102577625003689 35 59 4 0.0677966101694915 0.114285714285714
GO:BP GO:1990668 vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane 0.000109780977738652 6 118 3 0.0254237288135593 0.5
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.000119845796025664 182 128 9 0.0703125 0.0494505494505494
GO:BP GO:0006508 proteolysis 0.000121299238699019 1836 138 32 0.231884057971014 0.0174291938997821
GO:BP GO:0002253 activation of immune response 0.000126839306214065 568 137 16 0.116788321167883 0.028169014084507
GO:BP GO:0052547 regulation of peptidase activity 0.000131879437903417 467 96 12 0.125 0.0256959314775161
GO:BP GO:0071347 cellular response to interleukin-1 0.000132915357209878 185 128 9 0.0703125 0.0486486486486487
GO:BP GO:0050777 negative regulation of immune response 0.000142068330943255 157 115 8 0.0695652173913043 0.0509554140127389
GO:BP GO:0032648 regulation of interferon-beta production 0.00014221135252672 52 94 5 0.0531914893617021 0.0961538461538462
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 0.000158309328691933 177 137 9 0.0656934306569343 0.0508474576271186
GO:BP GO:0006471 protein ADP-ribosylation 0.000165522432222236 36 142 5 0.0352112676056338 0.138888888888889
GO:BP GO:0010646 regulation of cell communication 0.000166066082549689 3543 64 28 0.4375 0.00790290714084109
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.000166476121012986 3241 138 46 0.333333333333333 0.0141931502622647
GO:BP GO:0070269 pyroptosis 0.000166476121012986 18 137 4 0.0291970802919708 0.222222222222222
GO:BP GO:0032608 interferon-beta production 0.000166476121012986 54 94 5 0.0531914893617021 0.0925925925925926
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.000168534639999592 192 128 9 0.0703125 0.046875
GO:BP GO:1901532 regulation of hematopoietic progenitor cell differentiation 0.000172937012042834 89 58 5 0.0862068965517241 0.0561797752808989
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 0.000172937012042834 105 128 7 0.0546875 0.0666666666666667
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.000172937012042834 456 137 14 0.102189781021898 0.0307017543859649
GO:BP GO:0034612 response to tumor necrosis factor 0.000172937012042834 331 139 12 0.0863309352517986 0.0362537764350453
GO:BP GO:0060218 hematopoietic stem cell differentiation 0.000172937012042834 89 58 5 0.0862068965517241 0.0561797752808989
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.000238912980010898 1037 129 21 0.162790697674419 0.0202507232401157
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.00023932843107124 187 138 9 0.0652173913043478 0.0481283422459893
GO:BP GO:0050852 T cell receptor signaling pathway 0.000249960919089216 203 128 9 0.0703125 0.0443349753694581
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.000268337189344967 655 128 16 0.125 0.0244274809160305
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.000268417428200711 240 138 10 0.072463768115942 0.0416666666666667
GO:BP GO:0035457 cellular response to interferon-alpha 0.000275931721595796 13 71 3 0.0422535211267606 0.230769230769231
GO:BP GO:0035458 cellular response to interferon-beta 0.000286266128265504 21 137 4 0.0291970802919708 0.19047619047619
GO:BP GO:0044248 cellular catabolic process 0.000286266128265504 2347 136 36 0.264705882352941 0.0153387302939923
GO:BP GO:0032611 interleukin-1 beta production 0.000286266128265504 107 137 7 0.0510948905109489 0.0654205607476635
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 0.000302932624731723 172 58 6 0.103448275862069 0.0348837209302326
GO:BP GO:0009057 macromolecule catabolic process 0.000370544045624092 1468 96 21 0.21875 0.0143051771117166
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.000379452461435773 567 39 8 0.205128205128205 0.0141093474426808
GO:BP GO:0030097 hemopoiesis 0.000406115087840249 928 40 10 0.25 0.0107758620689655
GO:BP GO:0065009 regulation of molecular function 0.000431538993077283 3221 92 33 0.358695652173913 0.0102452654455138
GO:BP GO:0010952 positive regulation of peptidase activity 0.000452458833144745 205 138 9 0.0652173913043478 0.0439024390243902
GO:BP GO:2000736 regulation of stem cell differentiation 0.0004542294690666 115 28 4 0.142857142857143 0.0347826086956522
GO:BP GO:0002683 negative regulation of immune system process 0.000468993834290406 420 123 12 0.0975609756097561 0.0285714285714286
GO:BP GO:0030163 protein catabolic process 0.000506426146029838 974 134 20 0.149253731343284 0.0205338809034908
GO:BP GO:0010468 regulation of gene expression 0.000538713859251129 5196 138 62 0.449275362318841 0.0119322555812163
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.000549923906548003 966 40 10 0.25 0.010351966873706
GO:BP GO:0032728 positive regulation of interferon-beta production 0.000551631906612078 36 94 4 0.0425531914893617 0.111111111111111
GO:BP GO:0046700 heterocycle catabolic process 0.000551631906612078 602 39 8 0.205128205128205 0.0132890365448505
GO:BP GO:1901222 regulation of NIK/NF-kappaB signaling 0.000558404019420337 113 60 5 0.0833333333333333 0.0442477876106195
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.000582737199610729 608 39 8 0.205128205128205 0.0131578947368421
GO:BP GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 0.00059087488548293 73 94 5 0.0531914893617021 0.0684931506849315
GO:BP GO:0031329 regulation of cellular catabolic process 0.00064402817867661 866 129 18 0.13953488372093 0.0207852193995381
GO:BP GO:0019882 antigen processing and presentation 0.000656608139671476 234 128 9 0.0703125 0.0384615384615385
GO:BP GO:0019439 aromatic compound catabolic process 0.000677550232162719 623 39 8 0.205128205128205 0.0128410914927769
GO:BP GO:0010498 proteasomal protein catabolic process 0.000678659076359463 491 128 13 0.1015625 0.0264765784114053
GO:BP GO:0032612 interleukin-1 production 0.000725372013131907 126 137 7 0.0510948905109489 0.0555555555555556
GO:BP GO:0006521 regulation of cellular amino acid metabolic process 0.000775404813972995 64 58 4 0.0689655172413793 0.0625
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.000779715849671219 306 58 7 0.120689655172414 0.0228758169934641
GO:BP GO:0009892 negative regulation of metabolic process 0.000811806948034177 3479 134 45 0.335820895522388 0.0129347513653349
GO:BP GO:0002520 immune system development 0.000811806948034177 1020 40 10 0.25 0.00980392156862745
GO:BP GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 0.000837925873363098 95 128 6 0.046875 0.0631578947368421
GO:BP GO:1902186 regulation of viral release from host cell 0.000844662793251875 30 129 4 0.0310077519379845 0.133333333333333
GO:BP GO:0030162 regulation of proteolysis 0.000849374688026937 752 138 17 0.123188405797101 0.0226063829787234
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.000851726164429411 434 128 12 0.09375 0.0276497695852535
GO:BP GO:1901361 organic cyclic compound catabolic process 0.000871619571301606 651 39 8 0.205128205128205 0.0122887864823349
GO:BP GO:0032731 positive regulation of interleukin-1 beta production 0.000914876012335373 56 137 5 0.0364963503649635 0.0892857142857143
GO:BP GO:0062208 positive regulation of pattern recognition receptor signaling pathway 0.00101509967458891 43 94 4 0.0425531914893617 0.0930232558139535
GO:BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 0.00103279929826754 13 118 3 0.0254237288135593 0.230769230769231
GO:BP GO:0070213 protein auto-ADP-ribosylation 0.00103924463115707 11 142 3 0.0211267605633803 0.272727272727273
GO:BP GO:0035556 intracellular signal transduction 0.00104690174392617 2772 129 37 0.286821705426357 0.0133477633477633
GO:BP GO:1901565 organonitrogen compound catabolic process 0.00109936016445367 1358 96 19 0.197916666666667 0.0139911634756996
GO:BP GO:0035567 non-canonical Wnt signaling pathway 0.00111971935785012 151 28 4 0.142857142857143 0.0264900662251656
GO:BP GO:0006915 apoptotic process 0.0011397052675037 1990 96 24 0.25 0.0120603015075377
GO:BP GO:0035890 exit from host 0.00129642069385765 34 129 4 0.0310077519379845 0.117647058823529
GO:BP GO:0035891 exit from host cell 0.00129642069385765 34 129 4 0.0310077519379845 0.117647058823529
GO:BP GO:0019076 viral release from host cell 0.00129642069385765 34 129 4 0.0310077519379845 0.117647058823529
GO:BP GO:0071360 cellular response to exogenous dsRNA 0.00131192144188974 19 87 3 0.0344827586206897 0.157894736842105
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00133096514674133 323 128 10 0.078125 0.0309597523219814
GO:BP GO:0060330 regulation of response to interferon-gamma 0.00136061035424878 26 64 3 0.046875 0.115384615384615
GO:BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 0.00136061035424878 26 64 3 0.046875 0.115384615384615
GO:BP GO:0006954 inflammatory response 0.00136895022196555 794 137 17 0.124087591240876 0.0214105793450882
GO:BP GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 0.0014772678099961 78 58 4 0.0689655172413793 0.0512820512820513
GO:BP GO:0032651 regulation of interleukin-1 beta production 0.00161836935607021 102 137 6 0.0437956204379562 0.0588235294117647
GO:BP GO:0032732 positive regulation of interleukin-1 production 0.00170718395331096 65 137 5 0.0364963503649635 0.0769230769230769
GO:BP GO:0033238 regulation of cellular amine metabolic process 0.00176102934849704 82 58 4 0.0689655172413793 0.0487804878048781
GO:BP GO:0061013 regulation of mRNA catabolic process 0.00176102934849704 213 128 8 0.0625 0.0375586854460094
GO:BP GO:0002757 immune response-activating signal transduction 0.00182512551538884 477 128 12 0.09375 0.0251572327044025
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.00182512551538884 477 128 12 0.09375 0.0251572327044025
GO:BP GO:0019985 translesion synthesis 0.00184680622863596 42 116 4 0.0344827586206897 0.0952380952380952
GO:BP GO:0031145 anaphase-promoting complex-dependent catabolic process 0.00196061556515307 85 58 4 0.0689655172413793 0.0470588235294118
GO:BP GO:0002224 toll-like receptor signaling pathway 0.00209712301404309 161 92 6 0.0652173913043478 0.0372670807453416
GO:BP GO:0061025 membrane fusion 0.00210098986079149 179 118 7 0.0593220338983051 0.0391061452513966
GO:BP GO:0051252 regulation of RNA metabolic process 0.0021316450327433 3822 132 46 0.348484848484849 0.0120355834641549
GO:BP GO:0031348 negative regulation of defense response 0.0021316450327433 246 115 8 0.0695652173913043 0.032520325203252
GO:BP GO:0071359 cellular response to dsRNA 0.0021374959240896 23 87 3 0.0344827586206897 0.130434782608696
GO:BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.00215367972208327 154 138 7 0.0507246376811594 0.0454545454545455
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.00233192876055572 6603 124 65 0.524193548387097 0.00984401029834923
GO:BP GO:0006401 RNA catabolic process 0.00252128727991942 424 128 11 0.0859375 0.0259433962264151
GO:BP GO:0044546 NLRP3 inflammasome complex assembly 0.00260921105480351 16 137 3 0.0218978102189781 0.1875
GO:BP GO:0016579 protein deubiquitination 0.00273327111766632 292 128 9 0.0703125 0.0308219178082192
GO:BP GO:0010628 positive regulation of gene expression 0.00273365382108057 1160 111 18 0.162162162162162 0.0155172413793103
GO:BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 0.00282681730397319 19 118 3 0.0254237288135593 0.157894736842105
GO:BP GO:0062207 regulation of pattern recognition receptor signaling pathway 0.00287538457665946 108 94 5 0.0531914893617021 0.0462962962962963
GO:BP GO:0012501 programmed cell death 0.00301495913289218 2143 96 24 0.25 0.0111992533831078
GO:BP GO:0043170 macromolecule metabolic process 0.00312579886002828 9796 125 87 0.696 0.00888117599020008
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.00313818201757944 512 128 12 0.09375 0.0234375
GO:BP GO:0008219 cell death 0.00318356261758711 2292 96 25 0.260416666666667 0.0109075043630017
GO:BP GO:0032652 regulation of interleukin-1 production 0.00322587927484889 119 137 6 0.0437956204379562 0.0504201680672269
GO:BP GO:0002764 immune response-regulating signaling pathway 0.00325589516424273 515 128 12 0.09375 0.0233009708737864
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00337784616699048 3483 119 39 0.327731092436975 0.0111972437553833
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 0.00351115232482678 102 58 4 0.0689655172413793 0.0392156862745098
GO:BP GO:0039529 RIG-I signaling pathway 0.00354523203881951 26 94 3 0.0319148936170213 0.115384615384615
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 0.0036443083072526 218 28 4 0.142857142857143 0.018348623853211
GO:BP GO:0006301 postreplication repair 0.00367315633077572 52 116 4 0.0344827586206897 0.0769230769230769
GO:BP GO:0070646 protein modification by small protein removal 0.00386381004260432 310 128 9 0.0703125 0.0290322580645161
GO:BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 0.00389791567733769 96 115 5 0.0434782608695652 0.0520833333333333
GO:BP GO:0009894 regulation of catabolic process 0.00404011370206988 1033 129 18 0.13953488372093 0.0174249757986447
GO:BP GO:0000731 DNA synthesis involved in DNA repair 0.00416775854126444 54 116 4 0.0344827586206897 0.0740740740740741
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.00430475546787095 253 11 3 0.272727272727273 0.0118577075098814
GO:BP GO:0043488 regulation of mRNA stability 0.00439476604254604 191 128 7 0.0546875 0.0366492146596859
GO:BP GO:0060071 Wnt signaling pathway, planar cell polarity pathway 0.00443301717736294 110 58 4 0.0689655172413793 0.0363636363636364
GO:BP GO:0009056 catabolic process 0.00447244951051859 2744 136 36 0.264705882352941 0.0131195335276968
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 0.00453028675229835 111 58 4 0.0689655172413793 0.036036036036036
GO:BP GO:0044093 positive regulation of molecular function 0.00453028675229835 1771 140 27 0.192857142857143 0.0152456239412761
GO:BP GO:0032757 positive regulation of interleukin-8 production 0.00453028675229835 58 111 4 0.036036036036036 0.0689655172413793
GO:BP GO:0002223 stimulatory C-type lectin receptor signaling pathway 0.00464139018537294 112 58 4 0.0689655172413793 0.0357142857142857
GO:BP GO:1902750 negative regulation of cell cycle G2/M phase transition 0.0047826633767986 113 58 4 0.0689655172413793 0.0353982300884956
GO:BP GO:0010466 negative regulation of peptidase activity 0.00485467377891697 267 11 3 0.272727272727273 0.0112359550561798
GO:BP GO:0090175 regulation of establishment of planar polarity 0.00490873727373673 114 58 4 0.0689655172413793 0.0350877192982456
GO:BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 0.00503681107120514 115 58 4 0.0689655172413793 0.0347826086956522
GO:BP GO:0050790 regulation of catalytic activity 0.00503681107120514 2545 52 17 0.326923076923077 0.00667976424361493
GO:BP GO:0002758 innate immune response-activating signal transduction 0.00518554652053738 116 58 4 0.0689655172413793 0.0344827586206897
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 0.0053371152913597 117 58 4 0.0689655172413793 0.0341880341880342
GO:BP GO:0010499 proteasomal ubiquitin-independent protein catabolic process 0.00540205623201605 23 128 3 0.0234375 0.130434782608696
GO:BP GO:0043487 regulation of RNA stability 0.0055410811044579 201 128 7 0.0546875 0.0348258706467662
GO:BP GO:1901575 organic substance catabolic process 0.00584125790635087 2267 96 24 0.25 0.0105866784296427
GO:BP GO:0034121 regulation of toll-like receptor signaling pathway 0.00584125790635087 79 38 3 0.0789473684210526 0.0379746835443038
GO:BP GO:0019883 antigen processing and presentation of endogenous antigen 0.00602474932198313 26 118 3 0.0254237288135593 0.115384615384615
GO:BP GO:0045862 positive regulation of proteolysis 0.00602474932198313 378 91 8 0.0879120879120879 0.0211640211640212
GO:BP GO:0048863 stem cell differentiation 0.00602474932198313 258 28 4 0.142857142857143 0.0155038759689922
GO:BP GO:0007005 mitochondrion organization 0.00639393917016733 561 78 9 0.115384615384615 0.0160427807486631
GO:BP GO:0030522 intracellular receptor signaling pathway 0.00656035671782376 284 94 7 0.074468085106383 0.0246478873239437
GO:BP GO:0000266 mitochondrial fission 0.00662305982486271 41 77 3 0.038961038961039 0.0731707317073171
GO:BP GO:0001736 establishment of planar polarity 0.00742175412153457 130 58 4 0.0689655172413793 0.0307692307692308
GO:BP GO:0007164 establishment of tissue polarity 0.00742175412153457 130 58 4 0.0689655172413793 0.0307692307692308
GO:BP GO:0009968 negative regulation of signal transduction 0.00768036770647362 1364 64 13 0.203125 0.00953079178885631
GO:BP GO:0048585 negative regulation of response to stimulus 0.00780046719613134 1733 64 15 0.234375 0.00865551067512983
GO:BP GO:0097190 apoptotic signaling pathway 0.00782177744076961 600 91 10 0.10989010989011 0.0166666666666667
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 0.00788672013632859 4091 132 46 0.348484848484849 0.0112441945734539
GO:BP GO:0006900 vesicle budding from membrane 0.00794106658153973 107 72 4 0.0555555555555556 0.0373831775700935
GO:BP GO:0007259 receptor signaling pathway via JAK-STAT 0.00794106658153973 174 77 5 0.0649350649350649 0.028735632183908
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.00799543644948092 1160 94 15 0.159574468085106 0.0129310344827586
GO:BP GO:0030099 myeloid cell differentiation 0.00799991995001138 428 19 4 0.210526315789474 0.00934579439252336
GO:BP GO:0006513 protein monoubiquitination 0.00799991995001138 67 116 4 0.0344827586206897 0.0597014925373134
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.00805791727863979 223 91 6 0.0659340659340659 0.0269058295964126
GO:BP GO:0016050 vesicle organization 0.00831929400485659 341 133 9 0.0676691729323308 0.0263929618768328
GO:BP GO:0010467 gene expression 0.00915518869839539 6179 138 65 0.471014492753623 0.0105195015374656
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0091704621185795 217 96 6 0.0625 0.0276497695852535
GO:BP GO:0032760 positive regulation of tumor necrosis factor production 0.00919203253621524 88 92 4 0.0434782608695652 0.0454545454545455
GO:BP GO:0043687 post-translational protein modification 0.00944801925254394 362 128 9 0.0703125 0.0248618784530387
GO:BP GO:0032755 positive regulation of interleukin-6 production 0.00946773504664819 89 92 4 0.0434782608695652 0.0449438202247191
GO:BP GO:0097696 receptor signaling pathway via STAT 0.00963207956616166 184 77 5 0.0649350649350649 0.0271739130434783
GO:BP GO:0045861 negative regulation of proteolysis 0.00970066591924724 359 11 3 0.272727272727273 0.00835654596100279
GO:BP GO:1902531 regulation of intracellular signal transduction 0.00987135312506563 1842 129 25 0.193798449612403 0.0135722041259501
GO:BP GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 0.0100920590500627 91 92 4 0.0434782608695652 0.043956043956044
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.0102027971366258 4199 30 15 0.5 0.00357227911407478
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.0104303495436492 159 91 5 0.0549450549450549 0.0314465408805031
GO:BP GO:0090263 positive regulation of canonical Wnt signaling pathway 0.0114363856674487 151 58 4 0.0689655172413793 0.0264900662251656
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.0116829358096919 152 58 4 0.0689655172413793 0.0263157894736842
GO:BP GO:0018130 heterocycle biosynthetic process 0.0118588855842694 4269 30 15 0.5 0.00351370344342937
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0118678344079743 5746 61 31 0.508196721311475 0.00539505743125653
GO:BP GO:0048518 positive regulation of biological process 0.0119297083667673 6363 131 63 0.480916030534351 0.0099009900990099
GO:BP GO:0019438 aromatic compound biosynthetic process 0.0119914906814058 4278 30 15 0.5 0.00350631136044881
GO:BP GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 0.0120600966269512 45 91 3 0.032967032967033 0.0666666666666667
GO:BP GO:0071897 DNA biosynthetic process 0.0127992714031571 195 116 6 0.0517241379310345 0.0307692307692308
GO:BP GO:0009893 positive regulation of metabolic process 0.012870022580493 3783 119 39 0.327731092436975 0.0103092783505155
GO:BP GO:0044106 cellular amine metabolic process 0.012870022580493 163 139 6 0.0431654676258993 0.0368098159509202
GO:BP GO:0010648 negative regulation of cell communication 0.012870022580493 1468 64 13 0.203125 0.00885558583106267
GO:BP GO:0006402 mRNA catabolic process 0.0129048407553354 384 128 9 0.0703125 0.0234375
GO:BP GO:0023057 negative regulation of signaling 0.0130345235606025 1471 64 13 0.203125 0.008837525492862
GO:BP GO:0009617 response to bacterium 0.0134550242374794 743 139 14 0.100719424460432 0.018842530282638
GO:BP GO:0031397 negative regulation of protein ubiquitination 0.01352041984138 83 112 4 0.0357142857142857 0.0481927710843374
GO:BP GO:0043330 response to exogenous dsRNA 0.0137050944321171 50 87 3 0.0344827586206897 0.06
GO:BP GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 0.0138161526627191 48 91 3 0.032967032967033 0.0625
GO:BP GO:0009308 amine metabolic process 0.0143175617929649 168 139 6 0.0431654676258993 0.0357142857142857
GO:BP GO:0072527 pyrimidine-containing compound metabolic process 0.0143682459445857 84 53 3 0.0566037735849057 0.0357142857142857
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0145188488227429 1082 5 3 0.6 0.00277264325323475
GO:BP GO:0006355 regulation of transcription, DNA-templated 0.0145188488227429 3534 132 40 0.303030303030303 0.0113186191284663
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 0.014534534582461 3535 132 40 0.303030303030303 0.0113154172560113
GO:BP GO:2001141 regulation of RNA biosynthetic process 0.014852655194115 3540 132 40 0.303030303030303 0.0112994350282486
GO:BP GO:0038095 Fc-epsilon receptor signaling pathway 0.0148577100522972 167 58 4 0.0689655172413793 0.0239520958083832
GO:BP GO:0044766 multi-organism transport 0.0149580758123463 66 69 3 0.0434782608695652 0.0454545454545455
GO:BP GO:1902579 multi-organism localization 0.0149580758123463 66 69 3 0.0434782608695652 0.0454545454545455
GO:BP GO:0019222 regulation of metabolic process 0.0149580758123463 7148 139 72 0.517985611510791 0.0100727476217124
GO:BP GO:0048524 positive regulation of viral process 0.0149580758123463 91 50 3 0.06 0.032967032967033
GO:BP GO:0097300 programmed necrotic cell death 0.0156506765516696 54 86 3 0.0348837209302326 0.0555555555555556
GO:BP GO:0051254 positive regulation of RNA metabolic process 0.0157069137123171 1714 129 23 0.178294573643411 0.0134189031505251
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0158729301948408 4439 30 15 0.5 0.00337913944582113
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0166129492536229 1151 5 3 0.6 0.00260642919200695
GO:BP GO:0046483 heterocycle metabolic process 0.0168862955666576 5904 61 31 0.508196721311475 0.00525067750677507
GO:BP GO:0048523 negative regulation of cellular process 0.0171317542080148 5139 69 31 0.449275362318841 0.00603230200428099
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0173171760807414 470 11 3 0.272727272727273 0.00638297872340425
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.0173473949521237 263 19 3 0.157894736842105 0.0114068441064639
GO:BP GO:0043331 response to dsRNA 0.0173473949521237 56 87 3 0.0344827586206897 0.0535714285714286
GO:BP GO:0070936 protein K48-linked ubiquitination 0.0173610161658812 61 80 3 0.0375 0.0491803278688525
GO:BP GO:0001666 response to hypoxia 0.0173874592689181 367 91 7 0.0769230769230769 0.0190735694822888
GO:BP GO:0030111 regulation of Wnt signaling pathway 0.0174258027201595 376 28 4 0.142857142857143 0.0106382978723404
GO:BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 0.0174258027201595 221 112 6 0.0535714285714286 0.0271493212669683
GO:BP GO:0042157 lipoprotein metabolic process 0.0174258027201595 136 125 5 0.04 0.0367647058823529
GO:BP GO:0044092 negative regulation of molecular function 0.0186003735921971 1219 5 3 0.6 0.00246103363412633
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0186003735921971 5956 61 31 0.508196721311475 0.0052048354600403
GO:BP GO:0051239 regulation of multicellular organismal process 0.0186003735921971 2861 124 32 0.258064516129032 0.0111849003844809
GO:BP GO:0030177 positive regulation of Wnt signaling pathway 0.0186381905669245 184 28 3 0.107142857142857 0.016304347826087
GO:BP GO:2000027 regulation of animal organ morphogenesis 0.0186381905669245 184 28 3 0.107142857142857 0.016304347826087
GO:BP GO:0050856 regulation of T cell receptor signaling pathway 0.0186703283106913 42 122 3 0.0245901639344262 0.0714285714285714
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 0.0192896192950377 187 28 3 0.107142857142857 0.0160427807486631
GO:BP GO:0042981 regulation of apoptotic process 0.0196981746695233 1549 96 17 0.177083333333333 0.0109748224661072
GO:BP GO:0036293 response to decreased oxygen levels 0.0202376944549271 382 91 7 0.0769230769230769 0.0183246073298429
GO:BP GO:0032677 regulation of interleukin-8 production 0.020851447121902 99 111 4 0.036036036036036 0.0404040404040404
GO:BP GO:0010565 regulation of cellular ketone metabolic process 0.0210457176162031 194 28 3 0.107142857142857 0.0154639175257732
GO:BP GO:0033554 cellular response to stress 0.0218627530743331 2111 28 9 0.321428571428571 0.00426338228327807
GO:BP GO:0090304 nucleic acid metabolic process 0.021943274068349 5226 61 28 0.459016393442623 0.00535782625334864
GO:BP GO:0050794 regulation of cellular process 0.0221044426131347 11473 78 61 0.782051282051282 0.00531683082018653
GO:BP GO:0016070 RNA metabolic process 0.0221044426131347 4710 61 26 0.426229508196721 0.00552016985138004
GO:BP GO:0043067 regulation of programmed cell death 0.0233432439312972 1582 96 17 0.177083333333333 0.0107458912768647
GO:BP GO:0010941 regulation of cell death 0.0233432439312972 1720 96 18 0.1875 0.0104651162790698
GO:BP GO:1903311 regulation of mRNA metabolic process 0.0236181801866291 356 128 8 0.0625 0.0224719101123595
GO:BP GO:0051100 negative regulation of binding 0.0237075934932873 163 71 4 0.0563380281690141 0.0245398773006135
GO:BP GO:0032637 interleukin-8 production 0.0237075934932873 104 111 4 0.036036036036036 0.0384615384615385
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 0.0240165666385533 207 28 3 0.107142857142857 0.0144927536231884
GO:BP GO:0043462 regulation of ATPase activity 0.0242895642777245 80 72 3 0.0416666666666667 0.0375
GO:BP GO:0032722 positive regulation of chemokine production 0.0246382229346529 63 92 3 0.0326086956521739 0.0476190476190476
GO:BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.024998732520838 138 138 5 0.036231884057971 0.036231884057971
GO:BP GO:0070265 necrotic cell death 0.0250073752047647 68 86 3 0.0348837209302326 0.0441176470588235
GO:BP GO:0071456 cellular response to hypoxia 0.025114107776353 212 28 3 0.107142857142857 0.0141509433962264
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 0.0251773098681179 1617 119 20 0.168067226890756 0.0123685837971552
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 0.0251773098681179 1617 119 20 0.168067226890756 0.0123685837971552
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 0.0252978651041861 1618 119 20 0.168067226890756 0.0123609394313968
GO:BP GO:0032102 negative regulation of response to external stimulus 0.0258711473284182 406 115 8 0.0695652173913043 0.0197044334975369
GO:BP GO:0070482 response to oxygen levels 0.0260352310381318 408 91 7 0.0769230769230769 0.017156862745098
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 0.0264783162548476 243 115 6 0.0521739130434783 0.0246913580246914
GO:BP GO:0032496 response to lipopolysaccharide 0.0265964767631266 338 139 8 0.0575539568345324 0.0236686390532544
GO:BP GO:0036294 cellular response to decreased oxygen levels 0.0272612591104637 222 28 3 0.107142857142857 0.0135135135135135
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 0.027490506914661 223 28 3 0.107142857142857 0.0134529147982063
GO:BP GO:0006351 transcription, DNA-templated 0.0275765414187711 3714 132 40 0.303030303030303 0.0107700592353258
GO:BP GO:0097659 nucleic acid-templated transcription 0.0276528923628401 3715 132 40 0.303030303030303 0.0107671601615074
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0279118790740512 5848 92 42 0.456521739130435 0.00718194254445964
GO:BP GO:0032680 regulation of tumor necrosis factor production 0.0283090968662776 163 123 5 0.040650406504065 0.0306748466257669
GO:BP GO:0048522 positive regulation of cellular process 0.0286747280207532 5757 131 56 0.427480916030534 0.00972728851832552
GO:BP GO:0002699 positive regulation of immune effector process 0.0286747280207532 215 94 5 0.0531914893617021 0.0232558139534884
GO:BP GO:1903362 regulation of cellular protein catabolic process 0.0286800517731077 257 112 6 0.0535714285714286 0.0233463035019455
GO:BP GO:0032774 RNA biosynthetic process 0.0286800517731077 3731 132 40 0.303030303030303 0.0107209863307424
GO:BP GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 0.0291508846953917 92 138 4 0.0289855072463768 0.0434782608695652
GO:BP GO:0032640 tumor necrosis factor production 0.0291508846953917 165 123 5 0.040650406504065 0.0303030303030303
GO:BP GO:0006906 vesicle fusion 0.0294703858435916 108 118 4 0.0338983050847458 0.037037037037037
GO:BP GO:0048284 organelle fusion 0.0294991129083705 148 138 5 0.036231884057971 0.0337837837837838
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0294991129083705 6201 61 31 0.508196721311475 0.00499919367843896
GO:BP GO:0051098 regulation of binding 0.0294991129083705 365 80 6 0.075 0.0164383561643836
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0297736519367106 2518 30 10 0.333333333333333 0.0039714058776807
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.0299696620040204 167 123 5 0.040650406504065 0.029940119760479
GO:BP GO:0050727 regulation of inflammatory response 0.0299696620040204 381 128 8 0.0625 0.020997375328084
GO:BP GO:0019538 protein metabolic process 0.0299696620040204 5808 117 51 0.435897435897436 0.00878099173553719
GO:BP GO:0038093 Fc receptor signaling pathway 0.0299696620040204 238 28 3 0.107142857142857 0.0126050420168067
GO:BP GO:0032675 regulation of interleukin-6 production 0.0299696620040204 168 123 5 0.040650406504065 0.0297619047619048
GO:BP GO:0006974 cellular response to DNA damage stimulus 0.0299696620040204 888 93 11 0.118279569892473 0.0123873873873874
GO:BP GO:0071453 cellular response to oxygen levels 0.0301249735974418 240 28 3 0.107142857142857 0.0125
GO:BP GO:0061136 regulation of proteasomal protein catabolic process 0.0302771022501135 186 112 5 0.0446428571428571 0.0268817204301075
GO:BP GO:0045595 regulation of cell differentiation 0.0305790141855713 1679 31 8 0.258064516129032 0.00476474091721263
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.030610759720264 170 123 5 0.040650406504065 0.0294117647058824
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 0.0308519448520687 2555 44 13 0.295454545454545 0.0050880626223092
GO:BP GO:0032088 negative regulation of NF-kappaB transcription factor activity 0.0313451982798764 97 137 4 0.0291970802919708 0.0412371134020619
GO:BP GO:0032635 interleukin-6 production 0.031591087185611 172 123 5 0.040650406504065 0.0290697674418605
GO:BP GO:0051246 regulation of protein metabolic process 0.031942074270583 2704 96 24 0.25 0.00887573964497041
GO:BP GO:0090174 organelle membrane fusion 0.0319677690871377 114 118 4 0.0338983050847458 0.0350877192982456
GO:BP GO:0045930 negative regulation of mitotic cell cycle 0.0320646560762819 333 91 6 0.0659340659340659 0.018018018018018
GO:BP GO:0002237 response to molecule of bacterial origin 0.0326013111309909 361 139 8 0.0575539568345324 0.0221606648199446
GO:BP GO:0046822 regulation of nucleocytoplasmic transport 0.0328898978319073 115 61 3 0.0491803278688525 0.0260869565217391
GO:BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 0.0328898978319073 77 91 3 0.032967032967033 0.038961038961039
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.0336985433088066 1887 129 23 0.178294573643411 0.0121886592474828
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0343361398043726 1455 111 17 0.153153153153153 0.0116838487972509
GO:BP GO:0043112 receptor metabolic process 0.0347294790975666 174 80 4 0.05 0.0229885057471264
GO:BP GO:0050789 regulation of biological process 0.0347958212759133 12091 94 74 0.787234042553192 0.0061202547349268
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 0.035028025355426 262 28 3 0.107142857142857 0.0114503816793893
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0354327683567178 1042 31 6 0.193548387096774 0.00575815738963532
GO:BP GO:0051345 positive regulation of hydrolase activity 0.035575205075814 783 140 13 0.0928571428571429 0.016602809706258
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 0.035657177868722 265 28 3 0.107142857142857 0.0113207547169811
GO:BP GO:1901564 organonitrogen compound metabolic process 0.0357506408028918 6792 119 58 0.487394957983193 0.0085394581861013
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0357506408028918 5017 30 15 0.5 0.00298983456248754
GO:BP GO:0031323 regulation of cellular metabolic process 0.0362063952999669 6269 64 32 0.5 0.0051044823735843
GO:BP GO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process 0.0362063952999669 66 112 3 0.0267857142857143 0.0454545454545455
GO:BP GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 0.0362369334931535 103 138 4 0.0289855072463768 0.0388349514563107
GO:BP GO:0002718 regulation of cytokine production involved in immune response 0.0362369334931535 85 87 3 0.0344827586206897 0.0352941176470588
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.0364668631867826 155 92 4 0.0434782608695652 0.0258064516129032
GO:BP GO:0042180 cellular ketone metabolic process 0.0370701507931303 271 28 3 0.107142857142857 0.011070110701107
GO:BP GO:0016055 Wnt signaling pathway 0.0375714937864116 529 28 4 0.142857142857143 0.00756143667296786
GO:BP GO:0051656 establishment of organelle localization 0.0376449995901107 445 72 6 0.0833333333333333 0.0134831460674157
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0376449995901107 790 67 8 0.119402985074627 0.010126582278481
GO:BP GO:0198738 cell-cell signaling by wnt 0.0378393350407208 531 28 4 0.142857142857143 0.00753295668549906
GO:BP GO:0070534 protein K63-linked ubiquitination 0.0378393350407208 59 129 3 0.0232558139534884 0.0508474576271186
GO:BP GO:0080090 regulation of primary metabolic process 0.0387738650608064 6053 64 31 0.484375 0.00512142739137618
GO:BP GO:1901988 negative regulation of cell cycle phase transition 0.0390533053907147 281 28 3 0.107142857142857 0.0106761565836299
GO:BP GO:0050793 regulation of developmental process 0.0394171387099058 2605 31 10 0.32258064516129 0.00383877159309021
GO:BP GO:0044839 cell cycle G2/M phase transition 0.0394467551424793 283 28 3 0.107142857142857 0.0106007067137809
GO:BP GO:1903706 regulation of hemopoiesis 0.0395856725592129 424 19 3 0.157894736842105 0.00707547169811321
GO:BP GO:0061024 membrane organization 0.0395856725592129 973 142 15 0.105633802816901 0.0154162384378212
GO:BP GO:0044267 cellular protein metabolic process 0.0398939467633077 5229 117 46 0.393162393162393 0.00879709313444253
GO:BP GO:2000779 regulation of double-strand break repair 0.0402427637340967 87 91 3 0.032967032967033 0.0344827586206897
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0402610692128989 2719 30 10 0.333333333333333 0.00367782272894446
GO:BP GO:0051051 negative regulation of transport 0.0402610692128989 474 50 5 0.1 0.0105485232067511
GO:BP GO:0031667 response to nutrient levels 0.0402610692128989 482 17 3 0.176470588235294 0.00622406639004149
GO:BP GO:0031396 regulation of protein ubiquitination 0.0415374819879705 211 112 5 0.0446428571428571 0.023696682464455
GO:BP GO:0002009 morphogenesis of an epithelium 0.0419766197739903 560 28 4 0.142857142857143 0.00714285714285714
GO:BP GO:0001836 release of cytochrome c from mitochondria 0.042026399807887 59 138 3 0.0217391304347826 0.0508474576271186
GO:BP GO:0002698 negative regulation of immune effector process 0.0422977130833301 125 123 4 0.032520325203252 0.032
GO:BP GO:0002367 cytokine production involved in immune response 0.0423454733770976 94 87 3 0.0344827586206897 0.0319148936170213
GO:BP GO:0006366 transcription by RNA polymerase II 0.0424158531830042 2723 44 13 0.295454545454545 0.00477414616232097
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 0.042871448281902 298 28 3 0.107142857142857 0.0100671140939597
GO:BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 0.0436148295972687 68 122 3 0.0245901639344262 0.0441176470588235
GO:BP GO:0009991 response to extracellular stimulus 0.0453973117481276 512 17 3 0.176470588235294 0.005859375
GO:BP GO:0050729 positive regulation of inflammatory response 0.0457793710341712 142 60 3 0.05 0.0211267605633803
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0461935987901865 8390 96 56 0.583333333333333 0.0066746126340882
GO:BP GO:0051865 protein autoubiquitination 0.047126300176711 75 115 3 0.0260869565217391 0.04
GO:BP GO:0032642 regulation of chemokine production 0.0474483185552182 94 92 3 0.0326086956521739 0.0319148936170213
GO:BP GO:0006464 cellular protein modification process 0.0479987583171972 4041 117 37 0.316239316239316 0.00915614946795348
GO:BP GO:0036211 protein modification process 0.0479987583171972 4041 117 37 0.316239316239316 0.00915614946795348
GO:BP GO:1903363 negative regulation of cellular protein catabolic process 0.0483043901800273 78 112 3 0.0267857142857143 0.0384615384615385
GO:BP GO:0001525 angiogenesis 0.0483199492140717 617 27 4 0.148148148148148 0.00648298217179903
GO:BP GO:0043086 negative regulation of catalytic activity 0.0490035643571258 851 11 3 0.272727272727273 0.00352526439482961
GO:BP GO:0051259 protein complex oligomerization 0.0496815488566677 234 108 5 0.0462962962962963 0.0213675213675214
GO:CC GO:0005829 cytosol 1.30594160491833e-09 5303 95 59 0.621052631578947 0.0111257778615878
GO:CC GO:0005737 cytoplasm 1.63361797742315e-06 11911 97 86 0.88659793814433 0.0072202166064982
GO:CC GO:0005634 nucleus 0.000625839370355781 7592 80 52 0.65 0.00684931506849315
GO:CC GO:0031981 nuclear lumen 0.00082273763592801 4444 47 25 0.531914893617021 0.00562556255625563
GO:CC GO:0042824 MHC class I peptide loading complex 0.00110303687302972 9 118 3 0.0254237288135593 0.333333333333333
GO:CC GO:0005654 nucleoplasm 0.00110303687302972 4102 65 29 0.446153846153846 0.00706972208678693
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00110303687302972 11296 80 65 0.8125 0.0057542492917847
GO:CC GO:0000502 proteasome complex 0.00153804937981068 66 58 4 0.0689655172413793 0.0606060606060606
GO:CC GO:1905369 endopeptidase complex 0.00198525874884851 72 58 4 0.0689655172413793 0.0555555555555556
GO:CC GO:0043233 organelle lumen 0.00212442022716643 5565 83 41 0.493975903614458 0.00736747529200359
GO:CC GO:0031974 membrane-enclosed lumen 0.00212442022716643 5565 83 41 0.493975903614458 0.00736747529200359
GO:CC GO:0005622 intracellular anatomical structure 0.00212442022716643 14790 97 90 0.927835051546392 0.00608519269776876
GO:CC GO:0070013 intracellular organelle lumen 0.00218666264119648 5402 47 26 0.553191489361702 0.00481303221029248
GO:CC GO:0005730 nucleolus 0.00317123890193463 955 91 14 0.153846153846154 0.0146596858638743
GO:CC GO:0061702 inflammasome complex 0.00330860685889413 16 137 3 0.0218978102189781 0.1875
GO:CC GO:1905368 peptidase complex 0.00332334286899872 96 58 4 0.0689655172413793 0.0416666666666667
GO:CC GO:0043229 intracellular organelle 0.00432503474223802 12491 80 67 0.8375 0.00536386198062605
GO:CC GO:0016605 PML body 0.00476483496522718 102 112 5 0.0446428571428571 0.0490196078431373
GO:CC GO:0005839 proteasome core complex 0.00636114307881308 23 128 3 0.0234375 0.130434782608696
GO:CC GO:0012505 endomembrane system 0.00972610760904961 4640 142 52 0.366197183098592 0.0112068965517241
GO:CC GO:0043227 membrane-bounded organelle 0.0113718762928233 12858 80 67 0.8375 0.00521076372686265
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0301281356156144 735 140 13 0.0928571428571429 0.017687074829932
GO:CC GO:0000932 P-body 0.0321029483332704 91 129 4 0.0310077519379845 0.043956043956044
GO:CC GO:0031410 cytoplasmic vesicle 0.0425017600905515 2424 139 29 0.20863309352518 0.011963696369637
GO:CC GO:0097708 intracellular vesicle 0.0425017600905515 2428 139 29 0.20863309352518 0.0119439868204283
GO:CC GO:0043226 organelle 0.0461940102759936 14008 80 69 0.8625 0.00492575671045117
GO:CC GO:1904724 tertiary granule lumen 0.0496088797576981 55 131 3 0.0229007633587786 0.0545454545454545
GO:MF GO:0003725 double-stranded RNA binding 6.86010284362213e-11 77 94 11 0.117021276595745 0.142857142857143
GO:MF GO:0001730 2'-5'-oligoadenylate synthetase activity 1.25281378597979e-08 4 52 4 0.0769230769230769 1
GO:MF GO:0042802 identical protein binding 9.20074795962715e-06 2067 95 30 0.315789473684211 0.0145137880986938
GO:MF GO:1990404 protein ADP-ribosylase activity 1.13359121166763e-05 16 142 5 0.0352112676056338 0.3125
GO:MF GO:0003724 RNA helicase activity 6.72873253145354e-05 76 124 7 0.0564516129032258 0.0921052631578947
GO:MF GO:0070566 adenylyltransferase activity 0.000126956113585978 33 52 4 0.0769230769230769 0.121212121212121
GO:MF GO:0015433 ABC-type peptide antigen transporter activity 0.000126956113585978 5 118 3 0.0254237288135593 0.6
GO:MF GO:0015440 ABC-type peptide transporter activity 0.000126956113585978 5 118 3 0.0254237288135593 0.6
GO:MF GO:0003950 NAD+ ADP-ribosyltransferase activity 0.000126956113585978 27 142 5 0.0352112676056338 0.185185185185185
GO:MF GO:0004842 ubiquitin-protein transferase activity 0.000163885357980233 442 134 14 0.104477611940299 0.0316742081447964
GO:MF GO:0016763 transferase activity, transferring pentosyl groups 0.000163885357980233 56 79 5 0.0632911392405063 0.0892857142857143
GO:MF GO:0046978 TAP1 binding 0.000189555030242597 6 118 3 0.0254237288135593 0.5
GO:MF GO:0019787 ubiquitin-like protein transferase activity 0.000233319497177164 465 134 14 0.104477611940299 0.0301075268817204
GO:MF GO:0003727 single-stranded RNA binding 0.000233319497177164 92 94 6 0.0638297872340425 0.0652173913043478
GO:MF GO:0004386 helicase activity 0.000370963527002169 162 124 8 0.0645161290322581 0.0493827160493827
GO:MF GO:0003824 catalytic activity 0.000370963527002169 5896 136 67 0.492647058823529 0.0113636363636364
GO:MF GO:0003723 RNA binding 0.000424550910196581 1943 128 30 0.234375 0.0154400411734431
GO:MF GO:0017111 nucleoside-triphosphatase activity 0.000468859723059085 872 124 18 0.145161290322581 0.0206422018348624
GO:MF GO:0046977 TAP binding 0.00049589164566363 9 118 3 0.0254237288135593 0.333333333333333
GO:MF GO:0016787 hydrolase activity 0.000517700397272058 2615 128 36 0.28125 0.0137667304015296
GO:MF GO:0016462 pyrophosphatase activity 0.000821473181951441 928 124 18 0.145161290322581 0.0193965517241379
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.000821473181951441 930 124 18 0.145161290322581 0.0193548387096774
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.000821473181951441 930 124 18 0.145161290322581 0.0193548387096774
GO:MF GO:0003712 transcription coregulator activity 0.000917398584323892 506 129 13 0.10077519379845 0.0256916996047431
GO:MF GO:0016887 ATPase activity 0.00173131990568515 488 124 12 0.0967741935483871 0.0245901639344262
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.00231415952633759 314 91 8 0.0879120879120879 0.0254777070063694
GO:MF GO:0003713 transcription coactivator activity 0.00231415952633759 280 129 9 0.0697674418604651 0.0321428571428571
GO:MF GO:0140098 catalytic activity, acting on RNA 0.00255062256523243 395 94 9 0.0957446808510638 0.0227848101265823
GO:MF GO:0016740 transferase activity 0.00283394174096851 2357 116 29 0.25 0.0123037759864234
GO:MF GO:1901363 heterocyclic compound binding 0.00299182032227067 6228 79 42 0.531645569620253 0.00674373795761079
GO:MF GO:0042288 MHC class I protein binding 0.00337607381582808 20 118 3 0.0254237288135593 0.15
GO:MF GO:0016779 nucleotidyltransferase activity 0.00337607381582808 135 78 5 0.0641025641025641 0.037037037037037
GO:MF GO:0097159 organic cyclic compound binding 0.00377087963541779 6309 79 42 0.531645569620253 0.00665715644317641
GO:MF GO:0042803 protein homodimerization activity 0.00388678046869428 676 37 7 0.189189189189189 0.0103550295857988
GO:MF GO:0140359 ABC-type transporter activity 0.00477486373979613 23 118 3 0.0254237288135593 0.130434782608696
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 0.00553110976138612 1847 139 27 0.194244604316547 0.0146182999458581
GO:MF GO:1901265 nucleoside phosphate binding 0.00572733339397213 2172 139 30 0.215827338129496 0.0138121546961326
GO:MF GO:0003714 transcription corepressor activity 0.00572733339397213 187 67 5 0.0746268656716418 0.0267379679144385
GO:MF GO:0097367 carbohydrate derivative binding 0.00596799584256788 2285 87 22 0.252873563218391 0.00962800875273523
GO:MF GO:0043167 ion binding 0.00730406903157035 6057 56 30 0.535714285714286 0.00495294700346706
GO:MF GO:0005515 protein binding 0.00730406903157035 14767 142 127 0.894366197183099 0.0086002573305343
GO:MF GO:0032555 purine ribonucleotide binding 0.00730406903157035 1918 139 27 0.194244604316547 0.0140771637122002
GO:MF GO:0042605 peptide antigen binding 0.0073817345786867 30 118 3 0.0254237288135593 0.1
GO:MF GO:0032553 ribonucleotide binding 0.00752856644164378 1935 139 27 0.194244604316547 0.013953488372093
GO:MF GO:0017076 purine nucleotide binding 0.00752856644164378 1933 139 27 0.194244604316547 0.0139679255043973
GO:MF GO:0046983 protein dimerization activity 0.00752856644164378 1069 37 8 0.216216216216216 0.00748362956033676
GO:MF GO:0016504 peptidase activator activity 0.00752856644164378 42 86 3 0.0348837209302326 0.0714285714285714
GO:MF GO:0003676 nucleic acid binding 0.00823737345479532 4276 87 33 0.379310344827586 0.00771749298409729
GO:MF GO:0000166 nucleotide binding 0.00858689312716947 2171 139 29 0.20863309352518 0.0133578995854445
GO:MF GO:0061630 ubiquitin protein ligase activity 0.00893479458235673 305 129 8 0.062015503875969 0.0262295081967213
GO:MF GO:0061659 ubiquitin-like protein ligase activity 0.0109143612234409 316 129 8 0.062015503875969 0.0253164556962025
GO:MF GO:1904680 peptide transmembrane transporter activity 0.0109442018468187 37 118 3 0.0254237288135593 0.0810810810810811
GO:MF GO:0032813 tumor necrosis factor receptor superfamily binding 0.0119500396055189 49 92 3 0.0326086956521739 0.0612244897959184
GO:MF GO:0042287 MHC protein binding 0.0124006364817041 39 118 3 0.0254237288135593 0.0769230769230769
GO:MF GO:0140096 catalytic activity, acting on a protein 0.0128153256636894 2332 116 26 0.224137931034483 0.0111492281303602
GO:MF GO:0036094 small molecule binding 0.0136881634382114 2506 56 16 0.285714285714286 0.00638467677573823
GO:MF GO:0140110 transcription regulator activity 0.0138501078392553 1935 119 23 0.19327731092437 0.0118863049095607
GO:MF GO:0043168 anion binding 0.0179255888072832 2418 139 30 0.215827338129496 0.0124069478908189
GO:MF GO:0008270 zinc ion binding 0.0199576234153839 833 139 14 0.100719424460432 0.0168067226890756
GO:MF GO:0005525 GTP binding 0.0217862102167105 381 75 6 0.08 0.015748031496063
GO:MF GO:0032550 purine ribonucleoside binding 0.0224714917446437 386 75 6 0.08 0.0155440414507772
GO:MF GO:0001883 purine nucleoside binding 0.0226124878225486 389 75 6 0.08 0.0154241645244216
GO:MF GO:0032549 ribonucleoside binding 0.0226124878225486 389 75 6 0.08 0.0154241645244216
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.0226504394861398 283 103 6 0.058252427184466 0.0212014134275618
GO:MF GO:0001882 nucleoside binding 0.0229356933523778 395 75 6 0.08 0.0151898734177215
GO:MF GO:0019001 guanyl nucleotide binding 0.0241655729273004 403 75 6 0.08 0.0148883374689826
GO:MF GO:0032561 guanyl ribonucleotide binding 0.0241655729273004 403 75 6 0.08 0.0148883374689826
GO:MF GO:0042887 amide transmembrane transporter activity 0.0248981081533118 58 118 3 0.0254237288135593 0.0517241379310345
GO:MF GO:0008134 transcription factor binding 0.0256851601777037 676 61 7 0.114754098360656 0.0103550295857988
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.0273582720834703 281 80 5 0.0625 0.0177935943060498
GO:MF GO:0032559 adenyl ribonucleotide binding 0.0296539200654141 1565 134 20 0.149253731343284 0.012779552715655
GO:MF GO:0004518 nuclease activity 0.0303311428040998 207 113 5 0.0442477876106195 0.0241545893719807
GO:MF GO:0042626 ATPase-coupled transmembrane transporter activity 0.0306784241656774 67 118 3 0.0254237288135593 0.0447761194029851
GO:MF GO:0030554 adenyl nucleotide binding 0.0306784241656774 1578 134 20 0.149253731343284 0.0126742712294043
GO:MF GO:0005488 binding 0.0328018100683547 17074 95 93 0.978947368421053 0.00544687829448284
GO:MF GO:0003924 GTPase activity 0.0344098456832074 328 75 5 0.0666666666666667 0.0152439024390244
GO:MF GO:0005524 ATP binding 0.0352220741361872 1501 134 19 0.141791044776119 0.0126582278481013
GO:MF GO:0015399 primary active transmembrane transporter activity 0.0362663836521421 74 118 3 0.0254237288135593 0.0405405405405405
GO:MF GO:0004540 ribonuclease activity 0.0362663836521421 111 78 3 0.0384615384615385 0.027027027027027
GO:MF GO:0046872 metal ion binding 0.0378983539574421 4260 47 18 0.382978723404255 0.00422535211267606
GO:MF GO:0032182 ubiquitin-like protein binding 0.0398531987969225 100 91 3 0.032967032967033 0.03
GO:MF GO:0043169 cation binding 0.0449658793390896 4351 47 18 0.382978723404255 0.00413698000459664
HP HP:0030354 Abnormal serum interferon level 0.000628805934097405 11 85 5 0.0588235294117647 0.454545454545455
HP HP:0030355 Abnormal serum interferon-gamma level 0.000628805934097405 11 85 5 0.0588235294117647 0.454545454545455
HP HP:0011112 Abnormality of serum cytokine level 0.0173824658055237 23 40 4 0.1 0.173913043478261
HP HP:0011111 Abnormality of immune serum protein physiology 0.0173824658055237 24 40 4 0.1 0.166666666666667
KEGG KEGG:05164 Influenza A 5.4061622140441e-11 169 92 18 0.195652173913043 0.106508875739645
KEGG KEGG:05162 Measles 2.94732536513623e-08 139 92 14 0.152173913043478 0.100719424460432
KEGG KEGG:05160 Hepatitis C 5.93625016630592e-08 157 48 11 0.229166666666667 0.0700636942675159
KEGG KEGG:04621 NOD-like receptor signaling pathway 3.54757815514321e-07 177 92 14 0.152173913043478 0.0790960451977401
KEGG KEGG:05171 Coronavirus disease - COVID-19 1.17402236378235e-06 231 92 15 0.16304347826087 0.0649350649350649
KEGG KEGG:05169 Epstein-Barr virus infection 7.42231374030295e-06 198 92 13 0.141304347826087 0.0656565656565657
KEGG KEGG:04217 Necroptosis 0.000862797268604685 159 86 9 0.104651162790698 0.0566037735849057
KEGG KEGG:04622 RIG-I-like receptor signaling pathway 0.000997139863001002 70 116 7 0.0603448275862069 0.1
KEGG KEGG:05168 Herpes simplex virus 1 infection 0.00194751728067689 494 92 16 0.173913043478261 0.0323886639676113
KEGG KEGG:03050 Proteasome 0.00407482649769345 46 58 4 0.0689655172413793 0.0869565217391304
KEGG KEGG:04623 Cytosolic DNA-sensing pathway 0.00565206308413027 62 87 5 0.0574712643678161 0.0806451612903226
KEGG KEGG:04612 Antigen processing and presentation 0.00565206308413027 69 118 6 0.0508474576271186 0.0869565217391304
KEGG KEGG:05165 Human papillomavirus infection 0.0326080612793178 331 8 3 0.375 0.00906344410876133
MIRNA MIRNA:hsa-miR-146a-5p hsa-miR-146a-5p 7.4842480669797e-15 200 76 18 0.236842105263158 0.09
REAC REAC:R-HSA-913531 Interferon Signaling 1.58139843945517e-40 191 91 38 0.417582417582418 0.198952879581152
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 7.08066481280664e-38 66 77 26 0.337662337662338 0.393939393939394
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 2.28767903870238e-22 842 92 44 0.478260869565217 0.0522565320665083
REAC REAC:R-HSA-168256 Immune System 3.88530329242804e-16 2139 95 58 0.610526315789474 0.0271154745208041
REAC REAC:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 5.15064692438313e-15 78 54 13 0.240740740740741 0.166666666666667
REAC REAC:R-HSA-877300 Interferon gamma signaling 1.78393236696968e-14 87 129 17 0.131782945736434 0.195402298850575
REAC REAC:R-HSA-1169408 ISG15 antiviral mechanism 3.70902212221247e-09 70 134 12 0.0895522388059701 0.171428571428571
REAC REAC:R-HSA-8983711 OAS antiviral response 2.21159868030717e-07 9 87 5 0.0574712643678161 0.555555555555556
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 1.86755728940142e-06 370 134 20 0.149253731343284 0.0540540540540541
REAC REAC:R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 7.82641397147581e-06 34 134 7 0.0522388059701493 0.205882352941176
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 1.17378949736583e-05 99 128 10 0.078125 0.101010101010101
REAC REAC:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 1.61531192781475e-05 76 134 9 0.0671641791044776 0.118421052631579
REAC REAC:R-HSA-1236974 ER-Phagosome pathway 2.16665932288681e-05 83 128 9 0.0703125 0.108433734939759
REAC REAC:R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.000245949494850825 308 134 15 0.111940298507463 0.0487012987012987
REAC REAC:R-HSA-918233 TRAF3-dependent IRF activation pathway 0.000360727427423707 14 116 4 0.0344827586206897 0.285714285714286
REAC REAC:R-HSA-9683610 Maturation of nucleoprotein 0.000753872642165707 10 67 3 0.0447761194029851 0.3
REAC REAC:R-HSA-8939902 Regulation of RUNX2 expression and activity 0.000851447679594665 71 28 4 0.142857142857143 0.0563380281690141
REAC REAC:R-HSA-933541 TRAF6 mediated IRF7 activation 0.00260884864849254 27 116 4 0.0344827586206897 0.148148148148148
REAC REAC:R-HSA-8941858 Regulation of RUNX3 expression and activity 0.00260884864849254 54 58 4 0.0689655172413793 0.0740740740740741
REAC REAC:R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 0.00260884864849254 52 58 4 0.0689655172413793 0.0769230769230769
REAC REAC:R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 0.00260884864849254 55 58 4 0.0689655172413793 0.0727272727272727
REAC REAC:R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 0.00260884864849254 51 58 4 0.0689655172413793 0.0784313725490196
REAC REAC:R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 0.00260884864849254 50 58 4 0.0689655172413793 0.08
REAC REAC:R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 0.00260884864849254 55 58 4 0.0689655172413793 0.0727272727272727
REAC REAC:R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 0.00260884864849254 52 58 4 0.0689655172413793 0.0769230769230769
REAC REAC:R-HSA-4641257 Degradation of AXIN 0.00260884864849254 55 58 4 0.0689655172413793 0.0727272727272727
REAC REAC:R-HSA-180534 Vpu mediated degradation of CD4 0.00260884864849254 52 58 4 0.0689655172413793 0.0769230769230769
REAC REAC:R-HSA-180585 Vif-mediated degradation of APOBEC3G 0.00260884864849254 53 58 4 0.0689655172413793 0.0754716981132075
REAC REAC:R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 0.00260884864849254 52 58 4 0.0689655172413793 0.0769230769230769
REAC REAC:R-HSA-197264 Nicotinamide salvaging 0.00260884864849254 19 67 3 0.0447761194029851 0.157894736842105
REAC REAC:R-HSA-9604323 Negative regulation of NOTCH4 signaling 0.00260884864849254 53 58 4 0.0689655172413793 0.0754716981132075
REAC REAC:R-HSA-69613 p53-Independent G1/S DNA damage checkpoint 0.00260884864849254 52 58 4 0.0689655172413793 0.0769230769230769
REAC REAC:R-HSA-196807 Nicotinate metabolism 0.00260884864849254 31 88 4 0.0454545454545455 0.129032258064516
REAC REAC:R-HSA-169911 Regulation of Apoptosis 0.00260884864849254 53 58 4 0.0689655172413793 0.0754716981132075
REAC REAC:R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 0.00260884864849254 54 58 4 0.0689655172413793 0.0740740740740741
REAC REAC:R-HSA-69610 p53-Independent DNA Damage Response 0.00260884864849254 52 58 4 0.0689655172413793 0.0769230769230769
REAC REAC:R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 0.00260884864849254 50 58 4 0.0689655172413793 0.08
REAC REAC:R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 0.00265141687519063 12 116 3 0.0258620689655172 0.25
REAC REAC:R-HSA-5676590 NIK-->noncanonical NF-kB signaling 0.00265141687519063 59 58 4 0.0689655172413793 0.0677966101694915
REAC REAC:R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 0.00265141687519063 59 58 4 0.0689655172413793 0.0677966101694915
REAC REAC:R-HSA-351202 Metabolism of polyamines 0.00265141687519063 58 58 4 0.0689655172413793 0.0689655172413793
REAC REAC:R-HSA-5610783 Degradation of GLI2 by the proteasome 0.00265141687519063 60 58 4 0.0689655172413793 0.0666666666666667
REAC REAC:R-HSA-5362768 Hh mutants are degraded by ERAD 0.00265141687519063 56 58 4 0.0689655172413793 0.0714285714285714
REAC REAC:R-HSA-5610780 Degradation of GLI1 by the proteasome 0.00265141687519063 60 58 4 0.0689655172413793 0.0666666666666667
REAC REAC:R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 0.00265141687519063 60 58 4 0.0689655172413793 0.0666666666666667
REAC REAC:R-HSA-69541 Stabilization of p53 0.00265141687519063 57 58 4 0.0689655172413793 0.0701754385964912
REAC REAC:R-HSA-5387390 Hh mutants abrogate ligand secretion 0.00265141687519063 59 58 4 0.0689655172413793 0.0677966101694915
REAC REAC:R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 0.00265141687519063 60 58 4 0.0689655172413793 0.0666666666666667
REAC REAC:R-HSA-8878166 Transcriptional regulation by RUNX2 0.00265141687519063 118 28 4 0.142857142857143 0.0338983050847458
REAC REAC:R-HSA-4641258 Degradation of DVL 0.00265141687519063 57 58 4 0.0689655172413793 0.0701754385964912
REAC REAC:R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 0.00265141687519063 60 58 4 0.0689655172413793 0.0666666666666667
REAC REAC:R-HSA-5678895 Defective CFTR causes cystic fibrosis 0.00277156974835561 61 58 4 0.0689655172413793 0.0655737704918033
REAC REAC:R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 0.00320992901997912 64 58 4 0.0689655172413793 0.0625
REAC REAC:R-HSA-4608870 Asymmetric localization of PCP proteins 0.00320992901997912 64 58 4 0.0689655172413793 0.0625
REAC REAC:R-HSA-5358346 Hedgehog ligand biogenesis 0.00334454277656778 65 58 4 0.0689655172413793 0.0615384615384615
REAC REAC:R-HSA-69563 p53-Dependent G1 DNA Damage Response 0.00336240961657281 66 58 4 0.0689655172413793 0.0606060606060606
REAC REAC:R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint 0.00336240961657281 66 58 4 0.0689655172413793 0.0606060606060606
REAC REAC:R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 0.00336240961657281 66 58 4 0.0689655172413793 0.0606060606060606
REAC REAC:R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 0.00341520078447684 68 58 4 0.0689655172413793 0.0588235294117647
REAC REAC:R-HSA-1169091 Activation of NF-kappaB in B cells 0.00341520078447684 67 58 4 0.0689655172413793 0.0597014925373134
REAC REAC:R-HSA-5658442 Regulation of RAS by GAPs 0.00341520078447684 67 58 4 0.0689655172413793 0.0597014925373134
REAC REAC:R-HSA-69615 G1/S DNA Damage Checkpoints 0.00341520078447684 68 58 4 0.0689655172413793 0.0588235294117647
REAC REAC:R-HSA-68867 Assembly of the pre-replicative complex 0.00341520078447684 68 58 4 0.0689655172413793 0.0588235294117647
REAC REAC:R-HSA-8948751 Regulation of PTEN stability and activity 0.00355505302273575 69 58 4 0.0689655172413793 0.0579710144927536
REAC REAC:R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.00384483614354033 63 115 5 0.0434782608695652 0.0793650793650794
REAC REAC:R-HSA-68949 Orc1 removal from chromatin 0.00384483614354033 71 58 4 0.0689655172413793 0.0563380281690141
REAC REAC:R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 0.00404368448115629 73 58 4 0.0689655172413793 0.0547945205479452
REAC REAC:R-HSA-179419 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint 0.00404368448115629 74 58 4 0.0689655172413793 0.0540540540540541
REAC REAC:R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 0.00404368448115629 73 58 4 0.0689655172413793 0.0547945205479452
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.00404368448115629 800 95 17 0.178947368421053 0.02125
REAC REAC:R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.00404368448115629 74 58 4 0.0689655172413793 0.0540540540540541
REAC REAC:R-HSA-5656169 Termination of translesion DNA synthesis 0.00404368448115629 32 134 4 0.0298507462686567 0.125
REAC REAC:R-HSA-9683701 Translation of structural proteins 0.00404368448115629 28 67 3 0.0447761194029851 0.107142857142857
REAC REAC:R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.00404368448115629 80 140 6 0.0428571428571429 0.075
REAC REAC:R-HSA-5687128 MAPK6/MAPK4 signaling 0.00404368448115629 89 128 6 0.046875 0.0674157303370786
REAC REAC:R-HSA-1234174 Cellular response to hypoxia 0.0041172690808059 75 58 4 0.0689655172413793 0.0533333333333333
REAC REAC:R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 0.00427282687311122 76 58 4 0.0689655172413793 0.0526315789473684
REAC REAC:R-HSA-5619084 ABC transporter disorders 0.00437639785970505 77 58 4 0.0689655172413793 0.051948051948052
REAC REAC:R-HSA-176814 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.00437639785970505 77 58 4 0.0689655172413793 0.051948051948052
REAC REAC:R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 0.00476002348280836 79 58 4 0.0689655172413793 0.0506329113924051
REAC REAC:R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 0.0051020663837322 81 58 4 0.0689655172413793 0.0493827160493827
REAC REAC:R-HSA-9013694 Signaling by NOTCH4 0.0051020663837322 81 58 4 0.0689655172413793 0.0493827160493827
REAC REAC:R-HSA-69202 Cyclin E associated events during G1/S transition 0.0053945617710856 83 58 4 0.0689655172413793 0.0481927710843374
REAC REAC:R-HSA-195253 Degradation of beta-catenin by the destruction complex 0.0053945617710856 83 58 4 0.0689655172413793 0.0481927710843374
REAC REAC:R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 0.00569703354063574 85 58 4 0.0689655172413793 0.0470588235294118
REAC REAC:R-HSA-69002 DNA Replication Pre-Initiation 0.00569703354063574 85 58 4 0.0689655172413793 0.0470588235294118
REAC REAC:R-HSA-5632684 Hedgehog 'on' state 0.00569703354063574 85 58 4 0.0689655172413793 0.0470588235294118
REAC REAC:R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements 0.005849290134224 86 58 4 0.0689655172413793 0.0465116279069767
REAC REAC:R-HSA-168249 Innate Immune System 0.005849290134224 1073 137 26 0.18978102189781 0.0242311276794035
REAC REAC:R-HSA-446652 Interleukin-1 family signaling 0.00587161493826477 138 92 6 0.0652173913043478 0.0434782608695652
REAC REAC:R-HSA-5689880 Ub-specific processing proteases 0.00587161493826477 200 87 7 0.0804597701149425 0.035
REAC REAC:R-HSA-174143 APC/C-mediated degradation of cell cycle proteins 0.00607207642495435 88 58 4 0.0689655172413793 0.0454545454545455
REAC REAC:R-HSA-453276 Regulation of mitotic cell cycle 0.00607207642495435 88 58 4 0.0689655172413793 0.0454545454545455
REAC REAC:R-HSA-9020702 Interleukin-1 signaling 0.00620384046648274 101 128 6 0.046875 0.0594059405940594
REAC REAC:R-HSA-6807070 PTEN Regulation 0.00625336781682955 138 128 7 0.0546875 0.0507246376811594
REAC REAC:R-HSA-69052 Switching of origins to a post-replicative state 0.00653119719869831 91 58 4 0.0689655172413793 0.043956043956044
REAC REAC:R-HSA-4086400 PCP/CE pathway 0.00662197989002978 92 58 4 0.0689655172413793 0.0434782608695652
REAC REAC:R-HSA-5689603 UCH proteinases 0.00662197989002978 92 58 4 0.0689655172413793 0.0434782608695652
REAC REAC:R-HSA-157118 Signaling by NOTCH 0.00686255062740331 197 28 4 0.142857142857143 0.0203045685279188
REAC REAC:R-HSA-8878159 Transcriptional regulation by RUNX3 0.00688000782432871 94 58 4 0.0689655172413793 0.0425531914893617
REAC REAC:R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 0.00688000782432871 94 58 4 0.0689655172413793 0.0425531914893617
REAC REAC:R-HSA-5607764 CLEC7A (Dectin-1) signaling 0.00765070804988347 97 58 4 0.0689655172413793 0.0412371134020619
REAC REAC:R-HSA-202424 Downstream TCR signaling 0.00787100644435856 98 58 4 0.0689655172413793 0.0408163265306122
REAC REAC:R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 0.00839791277206637 100 58 4 0.0689655172413793 0.04
REAC REAC:R-HSA-933542 TRAF6 mediated NF-kB activation 0.00845743303607872 24 116 3 0.0258620689655172 0.125
REAC REAC:R-HSA-382556 ABC-family proteins mediated transport 0.00918699943419769 103 58 4 0.0689655172413793 0.0388349514563107
REAC REAC:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.00983193101945174 25 118 3 0.0254237288135593 0.12
REAC REAC:R-HSA-8878171 Transcriptional regulation by RUNX1 0.0110952269499899 200 128 8 0.0625 0.04
REAC REAC:R-HSA-5610787 Hedgehog 'off' state 0.0118847458067032 113 28 3 0.107142857142857 0.0265486725663717
REAC REAC:R-HSA-109581 Apoptosis 0.0127654796535428 174 62 5 0.0806451612903226 0.028735632183908
REAC REAC:R-HSA-5357801 Programmed Cell Death 0.013606541370657 177 62 5 0.0806451612903226 0.0282485875706215
REAC REAC:R-HSA-202403 TCR signaling 0.013606541370657 120 28 3 0.107142857142857 0.025
REAC REAC:R-HSA-69239 Synthesis of DNA 0.013606541370657 120 28 3 0.107142857142857 0.025
REAC REAC:R-HSA-9678108 SARS-CoV-1 Infection 0.0136935000365448 50 67 3 0.0447761194029851 0.06
REAC REAC:R-HSA-162909 Host Interactions of HIV factors 0.0150069204261059 125 28 3 0.107142857142857 0.024
REAC REAC:R-HSA-69306 DNA Replication 0.015905906499752 128 28 3 0.107142857142857 0.0234375
REAC REAC:R-HSA-69206 G1/S Transition 0.0166959426274049 131 28 3 0.107142857142857 0.0229007633587786
REAC REAC:R-HSA-162906 HIV Infection 0.0174804376204108 226 33 4 0.121212121212121 0.0176991150442478
REAC REAC:R-HSA-2871837 FCERI mediated NF-kB activation 0.0180950562530968 136 28 3 0.107142857142857 0.0220588235294118
REAC REAC:R-HSA-5621481 C-type lectin receptors (CLRs) 0.0180950562530968 136 28 3 0.107142857142857 0.0220588235294118
REAC REAC:R-HSA-3858494 Beta-catenin independent WNT signaling 0.0206368087795013 143 28 3 0.107142857142857 0.020979020979021
REAC REAC:R-HSA-5688426 Deubiquitination 0.0208581357780449 276 128 9 0.0703125 0.0326086956521739
REAC REAC:R-HSA-453279 Mitotic G1 phase and G1/S transition 0.0220053063864711 148 28 3 0.107142857142857 0.0202702702702703
REAC REAC:R-HSA-5358351 Signaling by Hedgehog 0.0220832087846575 149 28 3 0.107142857142857 0.0201342281879195
REAC REAC:R-HSA-69481 G2/M Checkpoints 0.0220832087846575 149 28 3 0.107142857142857 0.0201342281879195
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.0237809368641663 446 128 12 0.09375 0.0269058295964126
REAC REAC:R-HSA-5689896 Ovarian tumor domain proteases 0.0244373736520731 38 116 3 0.0258620689655172 0.0789473684210526
REAC REAC:R-HSA-69242 S Phase 0.0256753990100724 162 28 3 0.107142857142857 0.0185185185185185
REAC REAC:R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.0261890133736884 164 28 3 0.107142857142857 0.0182926829268293
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.0289512094483608 171 28 3 0.107142857142857 0.0175438596491228
REAC REAC:R-HSA-5619115 Disorders of transmembrane transporters 0.0296802194888865 173 28 3 0.107142857142857 0.0173410404624277
REAC REAC:R-HSA-1257604 PIP3 activates AKT signaling 0.0304520020982083 249 128 8 0.0625 0.0321285140562249
REAC REAC:R-HSA-5663205 Infectious disease 0.0319244219403623 815 33 7 0.212121212121212 0.00858895705521472
REAC REAC:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.0325479783486144 182 28 3 0.107142857142857 0.0164835164835165
REAC REAC:R-HSA-2467813 Separation of Sister Chromatids 0.0346081497302684 188 28 3 0.107142857142857 0.0159574468085106
REAC REAC:R-HSA-201681 TCF dependent signaling in response to WNT 0.0370807076515532 196 28 3 0.107142857142857 0.0153061224489796
REAC REAC:R-HSA-69275 G2/M Transition 0.0370807076515532 196 28 3 0.107142857142857 0.0153061224489796
REAC REAC:R-HSA-453274 Mitotic G2-G2/M phases 0.0378734073189388 198 28 3 0.107142857142857 0.0151515151515152
REAC REAC:R-HSA-451927 Interleukin-2 family signaling 0.038716491649011 44 127 3 0.0236220472440945 0.0681818181818182
REAC REAC:R-HSA-5663202 Diseases of signal transduction by growth factor receptors and second messengers 0.038716491649011 371 28 4 0.142857142857143 0.0107816711590297
REAC REAC:R-HSA-9679506 SARS-CoV Infections 0.0402022814882729 85 67 3 0.0447761194029851 0.0352941176470588
REAC REAC:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.0422360870925401 120 88 4 0.0454545454545455 0.0333333333333333
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 0.0448307658548656 217 28 3 0.107142857142857 0.0138248847926267
REAC REAC:R-HSA-68882 Mitotic Anaphase 0.0499393431480316 228 28 3 0.107142857142857 0.0131578947368421
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 1.23690492986728e-48 1617 124 77 0.620967741935484 0.0476190476190476
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 1.23690492986728e-48 272 124 45 0.362903225806452 0.165441176470588
TF TF:M07216 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT 1.278411485697e-44 440 134 50 0.373134328358209 0.113636363636364
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 3.60124046965805e-44 1651 132 76 0.575757575757576 0.0460327074500303
TF TF:M04020 Factor: IRF8; motif: NCGAAACCGAAACT 9.50343469718274e-44 992 125 62 0.496 0.0625
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 3.57927528392866e-41 622 104 48 0.461538461538462 0.0771704180064309
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 1.44082115046305e-40 1267 140 68 0.485714285714286 0.0536700868192581
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 2.55857610465858e-40 2396 132 83 0.628787878787879 0.0346410684474124
TF TF:M04018 Factor: IRF7; motif: NCGAAARYGAAANT 9.52958846917533e-40 619 130 51 0.392307692307692 0.0823909531502423
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 4.16110049985155e-39 2761 134 87 0.649253731343284 0.0315103223469757
TF TF:M11670 Factor: IRF-5; motif: NYGAAACCGAAACY 2.2250477290208e-37 871 124 54 0.435483870967742 0.0619977037887486
TF TF:M04015 Factor: IRF-4; motif: NCGAAACCGAAACYA 2.2250477290208e-37 2038 141 78 0.553191489361702 0.0382728164867517
TF TF:M10080 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN 4.45615492700866e-37 356 130 41 0.315384615384615 0.115168539325843
TF TF:M11685_1 Factor: IRF-8; motif: NCGAAACYGAAACYN; match class: 1 6.14703308605123e-37 118 117 29 0.247863247863248 0.245762711864407
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 9.3045105291196e-37 278 132 38 0.287878787878788 0.136690647482014
TF TF:M04788 Factor: IRF-1; motif: STTTCACTTTCNNT 1.61618927345547e-36 536 129 46 0.356589147286822 0.0858208955223881
TF TF:M11671 Factor: IRF-5; motif: NCGAAACCGAAACY 8.84576740542647e-36 389 120 40 0.333333333333333 0.102827763496144
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 5.86092731685793e-35 3795 132 93 0.704545454545455 0.0245059288537549
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 2.68380946011565e-34 3082 132 85 0.643939393939394 0.027579493835172
TF TF:M09733 Factor: STAT2; motif: NRGAAANNGAAACTNA 5.26869414543039e-34 2842 132 82 0.621212121212121 0.0288529204785362
TF TF:M11683_1 Factor: IRF-8; motif: NCGAAACCGAAACYN; match class: 1 1.90651718050201e-33 814 140 52 0.371428571428571 0.0638820638820639
TF TF:M11686 Factor: IRF-4; motif: NYGAAASYGAAACYN 4.30333196604855e-33 3391 132 87 0.659090909090909 0.0256561486287231
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 4.82670333442486e-33 3595 132 89 0.674242424242424 0.0247566063977747
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 4.93327320741961e-33 4690 132 99 0.75 0.0211087420042644
TF TF:M11687_1 Factor: IRF-4; motif: NCGAAACCGAAACYN; match class: 1 1.69615891482357e-32 474 120 40 0.333333333333333 0.0843881856540084
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 2.35857989033363e-32 535 140 44 0.314285714285714 0.0822429906542056
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 4.07172630580578e-32 336 134 37 0.276119402985075 0.110119047619048
TF TF:M09956 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN 1.40091060489324e-31 317 124 35 0.282258064516129 0.110410094637224
TF TF:M11664_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 2.21312910785161e-31 140 117 27 0.230769230769231 0.192857142857143
TF TF:M11677 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN 3.78356926387942e-31 470 130 40 0.307692307692308 0.0851063829787234
TF TF:M09733_1 Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 9.23536982410542e-31 367 124 36 0.290322580645161 0.0980926430517711
TF TF:M11682_1 Factor: IRF-8; motif: NYGAAASYGAAACYN; match class: 1 9.23536982410542e-31 543 117 40 0.341880341880342 0.0736648250460405
TF TF:M11684_1 Factor: IRF-8; motif: NYGAAACYGAAACTN; match class: 1 1.6575040792608e-30 832 117 46 0.393162393162393 0.0552884615384615
TF TF:M08887_1 Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 2.69540178834328e-30 73 94 21 0.223404255319149 0.287671232876712
TF TF:M00453_1 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 6.16244244284503e-29 332 140 35 0.25 0.105421686746988
TF TF:M11665_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 6.16244244284503e-29 246 117 30 0.256410256410256 0.121951219512195
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 9.39710071294238e-29 4664 134 95 0.708955223880597 0.020368782161235
TF TF:M11686_1 Factor: IRF-4; motif: NYGAAASYGAAACYN; match class: 1 1.32560245704993e-28 452 117 36 0.307692307692308 0.079646017699115
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 3.24499673937789e-28 562 130 40 0.307692307692308 0.0711743772241993
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 1.12668699198304e-27 1029 134 50 0.373134328358209 0.0485908649173955
TF TF:M00699 Factor: ICSBP; motif: RAARTGAAACTG 2.06812084458117e-27 1184 96 45 0.46875 0.0380067567567568
TF TF:M04016 Factor: IRF5; motif: CCGAAACCGAAACY 4.8538514897169e-26 314 104 29 0.278846153846154 0.0923566878980892
TF TF:M11681 Factor: IRF-9; motif: NCGAAACYGAAACYN 2.58999465333999e-25 97 97 20 0.206185567010309 0.206185567010309
TF TF:M11680 Factor: IRF-9; motif: NYGAAACYGAAACYN 9.71749246926058e-25 128 94 21 0.223404255319149 0.1640625
TF TF:M04015_1 Factor: IRF-4; motif: NCGAAACCGAAACYA; match class: 1 5.00459166408249e-24 158 97 22 0.22680412371134 0.139240506329114
TF TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 1.79843406079071e-23 823 94 36 0.382978723404255 0.0437424058323208
TF TF:M11672 Factor: IRF-5; motif: NCGAAACCGAAACY 2.35208668022729e-23 120 97 20 0.206185567010309 0.166666666666667
TF TF:M07323 Factor: IRF-4; motif: KRAAMNGAAANYN 8.30791468186679e-23 938 124 42 0.338709677419355 0.0447761194029851
TF TF:M04020_1 Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 1.86778749598107e-22 45 94 15 0.159574468085106 0.333333333333333
TF TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 2.17597032974189e-22 8370 119 104 0.873949579831933 0.0124253285543608
TF TF:M11670_1 Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 7.39043577076889e-20 36 94 13 0.138297872340426 0.361111111111111
TF TF:M00972 Factor: IRF; motif: RAAANTGAAAN 4.53748310873334e-19 1979 134 55 0.41044776119403 0.0277918140474987
TF TF:M09958 Factor: IRF-3; motif: RAAARGGAAANNGAAASNGA 5.44732990220524e-19 589 117 31 0.264957264957265 0.0526315789473684
TF TF:M11679_1 Factor: IRF-7; motif: NCGAAANCGAAANYN; match class: 1 5.12910930817531e-17 23 76 10 0.131578947368421 0.434782608695652
TF TF:M11673 Factor: IRF-5; motif: NCGAAACCGAAACY 1.03029456158705e-16 57 97 13 0.134020618556701 0.228070175438596
TF TF:M00699_1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 3.49105415345581e-16 47 94 12 0.127659574468085 0.25531914893617
TF TF:M00772_1 Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 2.76627973098731e-15 57 124 13 0.104838709677419 0.228070175438596
TF TF:M00258_1 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC; match class: 1 1.14357442719841e-14 30 94 10 0.106382978723404 0.333333333333333
TF TF:M04788_1 Factor: IRF-1; motif: STTTCACTTTCNNT; match class: 1 1.4498623332961e-14 17 115 9 0.0782608695652174 0.529411764705882
TF TF:M00972_1 Factor: IRF; motif: RAAANTGAAAN; match class: 1 1.99454437922579e-14 205 115 18 0.156521739130435 0.0878048780487805
TF TF:M07045_1 Factor: IRF-1; motif: NNRAAANNGAAASN; match class: 1 6.19236964750812e-14 19 117 9 0.0769230769230769 0.473684210526316
TF TF:M01882 Factor: IRF-2; motif: NNRAAAGTGAAASNNA 9.15123333571527e-14 258 134 20 0.149253731343284 0.0775193798449612
TF TF:M01279 Factor: IRF-3; motif: NBNBTTTCSCTTT 6.19448967128514e-13 1647 136 43 0.316176470588235 0.0261080752884032
TF TF:M11678 Factor: IRF-7; motif: NNGAAAGTGAAANTR 9.85844269385252e-13 179 117 16 0.136752136752137 0.0893854748603352
TF TF:M10080_1 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN; match class: 1 1.43683318221524e-12 11 94 7 0.074468085106383 0.636363636363636
TF TF:M09745 Factor: HELIOS; motif: RNARRRGGAASTGARAN 1.83433945424999e-11 3582 117 56 0.478632478632479 0.0156337241764377
TF TF:M07216_1 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT; match class: 1 3.98152469931131e-11 35 117 9 0.0769230769230769 0.257142857142857
TF TF:M04018_1 Factor: IRF7; motif: NCGAAARYGAAANT; match class: 1 1.83257751529853e-10 24 130 8 0.0615384615384615 0.333333333333333
TF TF:M04017 Factor: IRF5; motif: NACCGAAACYA 4.56359928984319e-10 195 90 13 0.144444444444444 0.0666666666666667
TF TF:M03793 Factor: IRF-7; motif: AARGGAAANNGAA 5.61573967849108e-10 1987 143 44 0.307692307692308 0.0221439355812783
TF TF:M00063 Factor: IRF-2; motif: GAAAAGYGAAASY 4.45751545638268e-09 685 136 24 0.176470588235294 0.035036496350365
TF TF:M11676_1 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN; match class: 1 8.7645988099953e-09 41 117 8 0.0683760683760684 0.195121951219512
TF TF:M09629_1 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN; match class: 1 2.6736986840169e-08 29 117 7 0.0598290598290598 0.241379310344828
TF TF:M11680_1 Factor: IRF-9; motif: NYGAAACYGAAACYN; match class: 1 4.22378595242918e-08 4 94 4 0.0425531914893617 1
TF TF:M07323_1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 5.2083048518308e-08 39 94 7 0.074468085106383 0.179487179487179
TF TF:M09957_1 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN; match class: 1 5.94614514877657e-08 22 94 6 0.0638297872340425 0.272727272727273
TF TF:M11671_1 Factor: IRF-5; motif: NCGAAACCGAAACY; match class: 1 1.21512606373888e-07 14 76 5 0.0657894736842105 0.357142857142857
TF TF:M10040_1 Factor: Blimp-1; motif: RAAAGNGAAAGTNN; match class: 1 4.27725927148387e-07 12 117 5 0.0427350427350427 0.416666666666667
TF TF:M09745_1 Factor: HELIOS; motif: RNARRRGGAASTGARAN; match class: 1 1.45383887683123e-06 495 83 14 0.168674698795181 0.0282828282828283
TF TF:M08295_1 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM; match class: 1 1.60548840090439e-06 4997 107 54 0.504672897196262 0.0108064838903342
TF TF:M11677_1 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN; match class: 1 1.92916712609937e-06 26 67 5 0.0746268656716418 0.192307692307692
TF TF:M04016_1 Factor: IRF5; motif: CCGAAACCGAAACY; match class: 1 2.62944429415797e-06 8 94 4 0.0425531914893617 0.5
TF TF:M01066 Factor: Blimp-1; motif: NRGRAAGKGAAAGKRN 6.99156071042477e-06 411 130 15 0.115384615384615 0.0364963503649635
TF TF:M01665 Factor: IRF-8; motif: AGTTTCW 7.66727994435928e-06 4771 133 60 0.451127819548872 0.0125759798784322
TF TF:M03916 Factor: PRDM1; motif: NRAAAGTGAAAGTNN 1.50955717602229e-05 948 139 23 0.165467625899281 0.0242616033755274
TF TF:M01066_1 Factor: Blimp-1; motif: NRGRAAGKGAAAGKRN; match class: 1 2.79107487989279e-05 11 117 4 0.0341880341880342 0.363636363636364
TF TF:M07121_1 Factor: Blimp-1; motif: NRAAAGTGAAAGTNN; match class: 1 2.79107487989279e-05 11 117 4 0.0341880341880342 0.363636363636364
TF TF:M00062 Factor: IRF-1; motif: SAAAAGYGAAACC 0.0001407290235874 576 134 16 0.119402985074627 0.0277777777777778
TF TF:M11674 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC 0.000168821080715065 4623 95 43 0.452631578947368 0.00930131948950898
TF TF:M00459_1 Factor: STAT5B; motif: NAWTTCYNGGAAWTN; match class: 1 0.000197371272184909 1896 102 26 0.254901960784314 0.0137130801687764
TF TF:M11675 Factor: IRF-3; motif: KCNGTTTCSNSGAAACCGAAACN 0.000280209812517673 4655 96 43 0.447916666666667 0.00923737916219119
TF TF:M09956_1 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN; match class: 1 0.000280658971851337 23 94 4 0.0425531914893617 0.173913043478261
TF TF:M10526_1 Factor: Blimp-1; motif: RRGNGAAAGNRANNN; match class: 1 0.000289993421033959 286 134 11 0.082089552238806 0.0384615384615385
TF TF:M04014_1 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR; match class: 1 0.000592786545723068 9 94 3 0.0319148936170213 0.333333333333333
TF TF:M09649 Factor: Blimp-1; motif: RAAAGTGAAAGTNN 0.000635588949849632 300 139 11 0.079136690647482 0.0366666666666667
TF TF:M03916_1 Factor: PRDM1; motif: NRAAAGTGAAAGTNN; match class: 1 0.000776657308896314 50 117 5 0.0427350427350427 0.1
TF TF:M00346 Factor: GATA-1; motif: NCWGATAACA 0.000913639271793828 4376 36 20 0.555555555555556 0.00457038391224863
TF TF:M07314 Factor: Blimp-1; motif: RGRAAGNGAAAG 0.000998642424775326 1460 134 25 0.186567164179104 0.0171232876712329
TF TF:M00205_1 Factor: GR; motif: GGTACAANNTGTYCTK; match class: 1 0.00116967663487233 1482 39 12 0.307692307692308 0.00809716599190283
TF TF:M10079_1 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC; match class: 1 0.0012305112721799 1164 138 22 0.159420289855072 0.0189003436426117
TF TF:M09649_1 Factor: Blimp-1; motif: RAAAGTGAAAGTNN; match class: 1 0.00148547046415192 10 117 3 0.0256410256410256 0.3
TF TF:M00457_1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 1 0.00150323720319207 1589 97 21 0.216494845360825 0.013215859030837
TF TF:M07229 Factor: STAT3; motif: NTTCYKGGAAN 0.00152606737527012 3717 117 41 0.35042735042735 0.0110304008609093
TF TF:M01279_1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 0.00193480759141866 101 71 5 0.0704225352112676 0.0495049504950495
TF TF:M01665_1 Factor: IRF-8; motif: AGTTTCW; match class: 1 0.00193577589920849 721 80 12 0.15 0.0166435506241331
TF TF:M09902_1 Factor: ESE-1; motif: NNANVAGGAAGTNN; match class: 1 0.00194029347827956 306 103 9 0.087378640776699 0.0294117647058824
TF TF:M10040 Factor: Blimp-1; motif: RAAAGNGAAAGTNN 0.00246070844134812 366 134 11 0.082089552238806 0.0300546448087432
TF TF:M11674_1 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC; match class: 1 0.00256924940240352 1663 141 27 0.191489361702128 0.0162357185808779
TF TF:M11378_1 Factor: ESE-1; motif: ACMAGGAAGTANNNNNNNWWAWW; match class: 1 0.00271373713758728 321 103 9 0.087378640776699 0.0280373831775701
TF TF:M00457 Factor: STAT5A; motif: NAWTTCYNGGAANYN 0.00271373713758728 4038 97 37 0.381443298969072 0.00916295195641407
TF TF:M01260_1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 1 0.00331272103609262 657 138 15 0.108695652173913 0.0228310502283105
TF TF:M09941_1 Factor: GR; motif: RGNACANMNTGTNCY; match class: 1 0.00331272103609262 2046 28 11 0.392857142857143 0.00537634408602151
TF TF:M00791_1 Factor: HNF3; motif: NWRARYAAAYANN; match class: 1 0.00331272103609262 749 108 14 0.12962962962963 0.0186915887850467
TF TF:M11559_1 Factor: FKHL14; motif: NYAMAYAAACAN; match class: 1 0.00394777153220817 762 108 14 0.12962962962963 0.0183727034120735
TF TF:M10079 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC 0.00408200737961158 2284 102 26 0.254901960784314 0.0113835376532399
TF TF:M07314_1 Factor: Blimp-1; motif: RGRAAGNGAAAG; match class: 1 0.00422073335893678 118 118 6 0.0508474576271186 0.0508474576271186
TF TF:M01996 Factor: AR; motif: GNNCNNNNTGTTCTN 0.00470644895983903 3085 38 16 0.421052631578947 0.00518638573743922
TF TF:M00192_1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 1 0.00483586941337462 1974 35 12 0.342857142857143 0.0060790273556231
TF TF:M09664_1 Factor: STAT3; motif: NTTCCYGGAAN; match class: 1 0.00483586941337462 1875 138 28 0.202898550724638 0.0149333333333333
TF TF:M08295 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM 0.00556468809745201 11711 95 74 0.778947368421053 0.00631884552984374
TF TF:M03906_1 Factor: HIC2; motif: RTGCCCRNN; match class: 1 0.00556468809745201 401 54 7 0.12962962962963 0.0174563591022444
TF TF:M00447_1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 1 0.0064001923462738 854 36 8 0.222222222222222 0.00936768149882904
TF TF:M00447 Factor: AR; motif: AGWACATNWTGTTCT 0.00642626268850889 4183 42 20 0.476190476190476 0.0047812574707148
TF TF:M08632 Factor: TEF-3:Dlx-2; motif: RMATWCYNNNYAATTA 0.00672540242189271 600 110 12 0.109090909090909 0.02
TF TF:M07229_1 Factor: STAT3; motif: NTTCYKGGAAN; match class: 1 0.00737979354682115 969 138 18 0.130434782608696 0.0185758513931889
TF TF:M00289_1 Factor: HFH3; motif: KNNTRTTTRTTTA; match class: 1 0.00739767755832494 817 108 14 0.12962962962963 0.0171358629130967
TF TF:M03875 Factor: IRF-5; motif: KTTTCGCTTTCMT 0.00798733181323265 100 54 4 0.0740740740740741 0.04
TF TF:M01883_1 Factor: IRF-4; motif: GAAARTA; match class: 1 0.00825736520140257 2948 89 27 0.303370786516854 0.00915875169606513
TF TF:M09959_1 Factor: IRF-4; motif: NAANGRGGAASTGAAASN; match class: 1 0.00856472008428164 395 27 5 0.185185185185185 0.0126582278481013
TF TF:M09663 Factor: STAT1; motif: YCMTTTCCNGGAAAWCNCATNN 0.00950184602153136 2762 141 36 0.25531914893617 0.0130340333091962
TF TF:M08890 Factor: MYB; motif: NNAACTGN 0.00983636625711183 1355 94 17 0.180851063829787 0.0125461254612546
TF TF:M00223 Factor: STAT; motif: TTCCCGKAA 0.00986145480186292 3501 97 32 0.329896907216495 0.00914024564410169
TF TF:M02015_1 Factor: HNF-3gamma; motif: TGTTTRYT; match class: 1 0.00986145480186292 742 108 13 0.12037037037037 0.0175202156334232
TF TF:M07204 Factor: AR; motif: ARGAACANNNTGTNC 0.0102015041005717 4906 38 20 0.526315789473684 0.0040766408479413
TF TF:M09958_1 Factor: IRF-3; motif: RAAARGGAAANNGAAASNGA; match class: 1 0.0107431575842323 93 117 5 0.0427350427350427 0.0537634408602151
TF TF:M12042 Factor: TEF-1; motif: NRCATWCCN 0.0119601261880439 5904 18 13 0.722222222222222 0.00220189701897019
TF TF:M00459 Factor: STAT5B; motif: NAWTTCYNGGAAWTN 0.0126227829905741 3076 97 29 0.298969072164948 0.00942782834850455
TF TF:M09664 Factor: STAT3; motif: NTTCCYGGAAN 0.01379618238762 5587 140 59 0.421428571428571 0.0105602291032755
TF TF:M11728 Factor: NF-1C; motif: NTTGGCNNNNTGCCARN 0.0140473403159864 2634 39 14 0.358974358974359 0.00531511009870919
TF TF:M00158 Factor: COUP-TF,; motif: TGAMCTTTGMMCYT 0.0140473403159864 2215 139 30 0.215827338129496 0.0135440180586907
TF TF:M07038_1 Factor: DBP; motif: TTRCATAANN; match class: 1 0.014600359338809 772 95 12 0.126315789473684 0.0155440414507772
TF TF:M09899 Factor: ehf; motif: NNANSAGGAAGTNNN 0.0152102434389512 457 27 5 0.185185185185185 0.0109409190371991
TF TF:M07228 Factor: STAT1; motif: NTTCYRGGAAA 0.0154751501657889 1919 97 21 0.216494845360825 0.0109431995831162
TF TF:M11445 Factor: Elf-1; motif: NANCAGGAAGTR 0.0161687885147344 1689 28 9 0.321428571428571 0.00532859680284192
TF TF:M00155 Factor: ARP-1; motif: TGARCCYTTGAMCCCW 0.0162517799321713 5581 82 38 0.463414634146341 0.00680881562444006
TF TF:M11445_1 Factor: Elf-1; motif: NANCAGGAAGTR; match class: 1 0.0178033934579436 83 83 4 0.0481927710843374 0.0481927710843374
TF TF:M07121 Factor: Blimp-1; motif: NRAAAGTGAAAGTNN 0.0178516187453109 401 134 10 0.0746268656716418 0.0249376558603491
TF TF:M04903_1 Factor: HNF-4alpha; motif: AGTCCAAR; match class: 1 0.0178830853462749 1534 31 9 0.290322580645161 0.00586701434159061
TF TF:M02015 Factor: HNF-3gamma; motif: TGTTTRYT 0.0178830853462749 2809 108 29 0.268518518518519 0.0103239587041652
TF TF:M09933_1 Factor: FOXP1; motif: TNTGTTTMY; match class: 1 0.018170126127842 634 71 9 0.126760563380282 0.0141955835962145
TF TF:M04609 Factor: AP-3; motif: TKGAAAKN 0.0184590720882136 4321 38 18 0.473684210526316 0.00416570238370747
TF TF:M01595_1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 1 0.0190198269542373 2700 97 26 0.268041237113402 0.00962962962962963
TF TF:M11453 Factor: ELFR; motif: AAMCAGGAAGTR 0.0191121583682096 488 27 5 0.185185185185185 0.0102459016393443
TF TF:M04745 Factor: CTCF; motif: CANNWRRTGGCAG 0.0192506774423115 8198 12 11 0.916666666666667 0.00134179068065382
TF TF:M00224_1 Factor: STAT1; motif: NNNSANTTCCGGGAANTGNSN; match class: 1 0.0192997779168512 2710 102 27 0.264705882352941 0.00996309963099631
TF TF:M11378 Factor: ESE-1; motif: ACMAGGAAGTANNNNNNNWWAWW 0.0195864374940215 3049 28 12 0.428571428571429 0.00393571662840275
TF TF:M01808_1 Factor: NMYC; motif: CAYCTG; match class: 1 0.0196109150727997 6149 141 63 0.446808510638298 0.0102455683851033
TF TF:M07417_1 Factor: Elf-1; motif: NNCAGGAAGNNN; match class: 1 0.0196109150727997 102 71 4 0.0563380281690141 0.0392156862745098
TF TF:M11334 Factor: ATF-4; motif: GGATGATGTCATCC 0.0199502704350647 6386 14 11 0.785714285714286 0.00172251800814281
TF TF:M09663_1 Factor: STAT1; motif: YCMTTTCCNGGAAAWCNCATNN; match class: 1 0.0201245098261101 554 138 12 0.0869565217391304 0.0216606498194946
TF TF:M11458 Factor: nerf; motif: AANCMGGAAGTR 0.0206400769696881 505 27 5 0.185185185185185 0.0099009900990099
TF TF:M09589 Factor: AR; motif: NGNACANNNTGTTCYNN 0.0207297266076255 5130 44 22 0.5 0.00428849902534113
TF TF:M07223 Factor: Pax-5; motif: NNRNKCAGYSRAGCRTGAC 0.0215972563190703 5600 41 22 0.536585365853659 0.00392857142857143
TF TF:M11321_1 Factor: C/EBPdelta; motif: NRTTGCGYAAYN; match class: 1 0.0230636980708916 1852 141 26 0.184397163120567 0.0140388768898488
TF TF:M01172_1 Factor: PU.1; motif: NNNNYYYACTTCCTCTTTY; match class: 1 0.0231050253209412 580 116 11 0.0948275862068965 0.0189655172413793
TF TF:M12334 Factor: ZBTB20; motif: NNAAYGTATRKN 0.0242979495972032 1214 115 17 0.147826086956522 0.014003294892916
TF TF:M00809_1 Factor: FOX; motif: KWTTGTTTRTTTW; match class: 1 0.0243104645302804 1054 76 12 0.157894736842105 0.0113851992409867
TF TF:M09930_1 Factor: foxm1; motif: TGTTTRCTYWNN; match class: 1 0.0247383149039117 1545 108 19 0.175925925925926 0.0122977346278317
TF TF:M01759_1 Factor: AML2; motif: AACCRCAA; match class: 1 0.0255890060583004 237 59 5 0.0847457627118644 0.0210970464135021
TF TF:M00175 Factor: AP-4; motif: VDCAGCTGNN 0.0255956477901768 2471 143 32 0.223776223776224 0.0129502225819506
TF TF:M00380 Factor: Pax-4; motif: RAAAAWTANNNNNNNNNNNNNNNYCACNCC 0.0262806268607143 852 121 14 0.115702479338843 0.0164319248826291
TF TF:M04453_1 Factor: AR; motif: RGGWACAYNGTGTWCYN; match class: 1 0.0264469086186246 3794 44 18 0.409090909090909 0.00474433315761729
TF TF:M11387_1 Factor: elf5; motif: NNNNMGGAAGTN; match class: 1 0.0268600096265086 221 133 7 0.0526315789473684 0.0316742081447964
TF TF:M12207 Factor: GATA-4; motif: NNGATAASNN 0.0269722504793167 2844 31 12 0.387096774193548 0.00421940928270042
TF TF:M04476_1 Factor: NR3C1; motif: NRGWACAYNRTGTWCYN; match class: 1 0.0271784732631916 5349 82 36 0.439024390243902 0.00673022994952328
TF TF:M09914 Factor: ER71; motif: NNARRCAGGAARYRGN 0.0279214264716586 550 27 5 0.185185185185185 0.00909090909090909
TF TF:M02377 Factor: ESR2; motif: NNRGGTCANNNTGMCCTN 0.0304064587314668 3517 63 22 0.349206349206349 0.00625533124822292
TF TF:M01484 Factor: Pitx1; motif: NNNNRGGGATTAAMNNN 0.0304064587314668 3417 17 9 0.529411764705882 0.00263388937664618
TF TF:M10092 Factor: TEF-1; motif: RCATTCCWGNNN 0.0310145983443165 3195 18 9 0.5 0.0028169014084507
TF TF:M00208_1 Factor: NF-kappaB; motif: NGGGACTTTCCA; match class: 1 0.0310145983443165 604 7 3 0.428571428571429 0.00496688741721854
TF TF:M04168_1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 0.0312528008923259 183 21 3 0.142857142857143 0.0163934426229508
TF TF:M03568 Factor: TR4; motif: STGACCTTT 0.0319986664123777 471 85 8 0.0941176470588235 0.0169851380042463
TF TF:M10016 Factor: Nur77; motif: AAAGGNCAN 0.0319986664123777 471 85 8 0.0941176470588235 0.0169851380042463
TF TF:M10025_1 Factor: p73; motif: NNRCAWGYCCARRCWTGYC; match class: 1 0.0322659516014844 1411 94 16 0.170212765957447 0.0113394755492558
TF TF:M04052 Factor: NFATc1; motif: TTTCCAYWRTGGAAA 0.0330734900214016 6663 24 16 0.666666666666667 0.00240132072639952
TF TF:M00476 Factor: FOXO4; motif: NNGTTGTTTACNTN 0.0334180029432657 2740 80 22 0.275 0.00802919708029197
TF TF:M10046_1 Factor: c-Rel; motif: NRNRGGGRAATKCCA; match class: 1 0.0335873081166886 734 98 11 0.112244897959184 0.0149863760217984
TF TF:M01260 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN 0.0335873081166886 2130 141 28 0.198581560283688 0.0131455399061033
TF TF:M00747_1 Factor: IRF-1; motif: TTCACTT; match class: 1 0.0342164430713893 933 90 12 0.133333333333333 0.0128617363344051
TF TF:M11814 Factor: T3R-beta; motif: NRGGTCAAAGGTCRN 0.0357328351927991 13972 60 53 0.883333333333333 0.00379330088748926
TF TF:M00225 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN 0.0365089987308834 3188 97 28 0.288659793814433 0.00878293601003764
TF TF:M00956 Factor: AR; motif: NNNNNNRGNACRNNGTGTTCTNNNNNN 0.0366239524359641 2717 38 13 0.342105263157895 0.00478468899521531
TF TF:M07421 Factor: HOXC-8; motif: GAATWAYARN 0.0378929941732053 1504 23 7 0.304347826086957 0.00465425531914894
TF TF:M12286 Factor: ZNF647; motif: NYAGGCCYAC 0.0378929941732053 6231 138 61 0.442028985507246 0.00978976087305408
TF TF:M08253 Factor: ER71:FIGLA; motif: RSCGGAARCAGSTGNN 0.0390673622393339 204 21 3 0.142857142857143 0.0147058823529412
TF TF:M03545_1 Factor: c-Rel; motif: NGGGAATYTCCN; match class: 1 0.0397731691815875 1011 17 5 0.294117647058824 0.00494559841740851
TF TF:M00339_1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 1 0.0398094730988016 1466 138 21 0.152173913043478 0.014324693042292
TF TF:M00641 Factor: HSF; motif: TTCCMGARGYTTC 0.0398094730988016 3599 48 18 0.375 0.00500138927479855
TF TF:M11675_1 Factor: IRF-3; motif: KCNGTTTCSNSGAAACCGAAACN; match class: 1 0.0399740919247075 1848 96 19 0.197916666666667 0.0102813852813853
TF TF:M08216 Factor: Elk-1:FOXI1; motif: ACCGGAAGTRTMAACAN 0.0399869881013693 7126 132 65 0.492424242424242 0.00912152680325568
TF TF:M07126_1 Factor: Smad2:Smad3:Smad4; motif: NTGTCTGNCACCT; match class: 1 0.0401970812711764 550 134 11 0.082089552238806 0.02
TF TF:M00621 Factor: C/EBPdelta; motif: MATTKCNTMAYY 0.040296703023929 3888 52 20 0.384615384615385 0.0051440329218107
TF TF:M04750_1 Factor: GR; motif: RGRACATTNTGTYC; match class: 1 0.0413296763448623 1704 39 10 0.256410256410256 0.00586854460093897
TF TF:M04249_1 Factor: FOXJ3; motif: RTAAACAA; match class: 1 0.0416809737501326 603 105 10 0.0952380952380952 0.0165837479270315
TF TF:M08899_1 Factor: SOX; motif: NNNNCWTTGTT; match class: 1 0.0429593859115823 154 29 3 0.103448275862069 0.0194805194805195
TF TF:M11360 Factor: c-MAF; motif: NTGCTGACNNNGCR 0.0429593859115823 221 44 4 0.0909090909090909 0.0180995475113122
TF TF:M00291_1 Factor: Freac-3; motif: NNNNNGTAAATAAACA; match class: 1 0.0432377084261696 1096 80 12 0.15 0.0109489051094891
TF TF:M00054_1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 1 0.0433565122642108 712 90 10 0.111111111111111 0.0140449438202247
TF TF:M08805 Factor: EAR2; motif: NCTYTGACCTN 0.043730098689676 1027 133 16 0.120300751879699 0.0155793573515093
TF TF:M12041 Factor: TEF-1; motif: CRCATWCCN 0.043730098689676 4709 19 11 0.578947368421053 0.00233595243151412
TF TF:M02117 Factor: STAT4; motif: TTMNNRGAAA 0.0438139798330836 1353 102 16 0.156862745098039 0.0118255728011826
TF TF:M10042_1 Factor: PR; motif: RGNACATTYTGTNCTN; match class: 1 0.0452657879167445 998 26 6 0.230769230769231 0.00601202404809619
TF TF:M00192 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN 0.0453300571130069 7611 28 19 0.678571428571429 0.00249638680856655
TF TF:M11985 Factor: NFATc2; motif: TTTTCCATGGAAAA 0.0453300571130069 5845 142 59 0.415492957746479 0.0100940975192472
TF TF:M03966_1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 1 0.0453300571130069 1577 23 7 0.304347826086957 0.00443880786303107
TF TF:M11363 Factor: c-MAF; motif: NTGCTGACNNWGCA 0.0453300571130069 422 80 7 0.0875 0.0165876777251185
TF TF:M00208 Factor: NF-kappaB; motif: NGGGACTTTCCA 0.0454613411760652 3757 138 41 0.297101449275362 0.0109129624700559
TF TF:M04168 Factor: CLOCK; motif: AACACGTGTN 0.0464114178715967 225 21 3 0.142857142857143 0.0133333333333333
TF TF:M00225_1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 0.0473665777819363 1922 138 25 0.181159420289855 0.0130072840790843
TF TF:M00054 Factor: NF-kappaB; motif: GGGAMTTYCC 0.0478077858445894 2444 20 8 0.4 0.00327332242225859
TF TF:M03833 Factor: NKX3A; motif: NCACTTANTYN 0.0478268726058588 895 126 14 0.111111111111111 0.0156424581005587
TF TF:M06132 Factor: ZNF823; motif: NYYACCAGCCCT 0.0484414862472055 55 86 3 0.0348837209302326 0.0545454545454545
TF TF:M09902 Factor: ESE-1; motif: NNANVAGGAAGTNN 0.0484414862472055 3200 137 36 0.262773722627737 0.01125
TF TF:M03547 Factor: ER-alpha; motif: TGACCYN 0.0490546904588141 4712 143 50 0.34965034965035 0.0106112054329372
TF TF:M11988_1 Factor: NFATc3; motif: NTTTCCRYGGAAAN; match class: 1 0.0490546904588141 6648 142 65 0.457746478873239 0.00977737665463297
TF TF:M10097_1 Factor: AP-4; motif: YCAGCTGNKN; match class: 1 0.0494133471084092 1554 143 22 0.153846153846154 0.0141570141570142
TF TF:M00774_1 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN; match class: 1 0.0496805826985329 192 90 5 0.0555555555555556 0.0260416666666667
WP WP:WP4197 The human immune response to tuberculosis 1.02714730241155e-14 23 77 11 0.142857142857143 0.478260869565217
WP WP:WP619 Type II interferon signaling (IFNG) 1.88421776437936e-12 37 102 12 0.117647058823529 0.324324324324324
WP WP:WP4880 Host-pathogen interaction of human corona viruses - Interferon induction 1.52665852365104e-10 33 92 10 0.108695652173913 0.303030303030303
WP WP:WP4868 Type I Interferon Induction and Signaling During SARS-CoV-2 Infection 4.45337159240725e-08 29 92 8 0.0869565217391304 0.275862068965517
WP WP:WP5039 SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response 2.30462735065229e-05 68 116 9 0.0775862068965517 0.132352941176471
WP WP:WP4705 Pathways of nucleic acid metabolism and innate immune sensing 0.000490446060961839 16 87 4 0.0459770114942529 0.25
WP WP:WP4912 SARS coronavirus and innate immunity 0.000490446060961839 31 87 5 0.0574712643678161 0.161290322580645
WP WP:WP4341 Non-genomic actions of 1,25 dihydroxyvitamin D3 0.000490446060961839 70 38 5 0.131578947368421 0.0714285714285714
WP WP:WP3865 Novel intracellular components of RIG-I-like receptor (RLR) pathway 0.000593646518074399 61 116 7 0.0603448275862069 0.114754098360656
WP WP:WP4655 Cytosolic DNA-sensing pathway 0.000757629973205325 74 137 8 0.0583941605839416 0.108108108108108
WP WP:WP2113 Type III interferon signaling 0.00154556595118921 10 77 3 0.038961038961039 0.3
WP WP:WP4877 Host-pathogen interaction of human corona viruses - MAPK signaling 0.00227369817280331 36 61 4 0.0655737704918033 0.111111111111111
WP WP:WP4217 Ebola Virus Pathway on Host 0.00298348696057575 130 19 4 0.210526315789474 0.0307692307692308
WP WP:WP183 Proteasome Degradation 0.00932397055695935 64 134 6 0.0447761194029851 0.09375
WP WP:WP4558 Overview of interferons-mediated signaling pathway 0.0465622129772093 37 77 3 0.038961038961039 0.0810810810810811
WP WP:WP5038 SARS-CoV-2 mitochondrial interactions 0.0465622129772093 32 87 3 0.0344827586206897 0.09375

pTNI19 transcription factor target enrichment of top program genes

TF enrichment of pTNI19
TFs corrosponding to activation of pTNI19. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.