pEpiTd24 program activity among Epithelial cells

Activation of pEpiTd24
pEpiTd24 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd24 by different cell subtypes
pEpiTd24 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd24 top program genes

Top genes of pEpiTd24 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd24 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd24
pEpiTd24 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0044281 small molecule metabolic process 1.6136927555556e-06 1921 117 37 0.316239316239316 0.0192608016657991
GO:BP GO:0006629 lipid metabolic process 1.97797446100332e-06 1457 128 33 0.2578125 0.0226492793411119
GO:BP GO:0010817 regulation of hormone levels 2.10880817854857e-06 536 106 18 0.169811320754717 0.0335820895522388
GO:BP GO:0043436 oxoacid metabolic process 3.91132761147194e-06 1057 112 25 0.223214285714286 0.0236518448438978
GO:BP GO:0006082 organic acid metabolic process 5.79859194163022e-06 1090 112 25 0.223214285714286 0.0229357798165138
GO:BP GO:0065008 regulation of biological quality 7.70241478110808e-06 4131 119 55 0.46218487394958 0.0133139675623336
GO:BP GO:0042445 hormone metabolic process 2.28684260178518e-05 228 123 12 0.0975609756097561 0.0526315789473684
GO:BP GO:0019752 carboxylic acid metabolic process 2.33854264347774e-05 1024 112 23 0.205357142857143 0.0224609375
GO:BP GO:0044242 cellular lipid catabolic process 3.35745904773962e-05 232 128 12 0.09375 0.0517241379310345
GO:BP GO:0016042 lipid catabolic process 5.76816543518667e-05 349 128 14 0.109375 0.0401146131805158
GO:BP GO:0032787 monocarboxylic acid metabolic process 7.78903847998911e-05 658 131 19 0.145038167938931 0.0288753799392097
GO:BP GO:0044255 cellular lipid metabolic process 8.61249340766089e-05 1075 117 23 0.196581196581197 0.0213953488372093
GO:BP GO:0015701 bicarbonate transport 0.000329505446921301 42 83 5 0.0602409638554217 0.119047619047619
GO:BP GO:0008202 steroid metabolic process 0.000461896612113208 342 137 13 0.0948905109489051 0.0380116959064327
GO:BP GO:0006694 steroid biosynthetic process 0.000522587465608198 196 137 10 0.072992700729927 0.0510204081632653
GO:BP GO:0044283 small molecule biosynthetic process 0.00080103547574503 704 133 18 0.135338345864662 0.0255681818181818
GO:BP GO:0007586 digestion 0.000990521376818335 141 57 6 0.105263157894737 0.0425531914893617
GO:BP GO:0006631 fatty acid metabolic process 0.00103581690143475 404 128 13 0.1015625 0.0321782178217822
GO:BP GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus 0.00135126356320352 36 141 5 0.0354609929078014 0.138888888888889
GO:BP GO:0006720 isoprenoid metabolic process 0.00135126356320352 144 128 8 0.0625 0.0555555555555556
GO:BP GO:0033500 carbohydrate homeostasis 0.00167040030082918 249 102 9 0.0882352941176471 0.036144578313253
GO:BP GO:0042593 glucose homeostasis 0.00167040030082918 248 102 9 0.0882352941176471 0.0362903225806452
GO:BP GO:0006693 prostaglandin metabolic process 0.00179118353795932 50 111 5 0.045045045045045 0.1
GO:BP GO:0006692 prostanoid metabolic process 0.00179118353795932 50 111 5 0.045045045045045 0.1
GO:BP GO:0006721 terpenoid metabolic process 0.00179118353795932 123 117 7 0.0598290598290598 0.0569105691056911
GO:BP GO:0044282 small molecule catabolic process 0.00200611982548379 439 131 13 0.099236641221374 0.0296127562642369
GO:BP GO:0055114 obsolete oxidation-reduction process 0.00211223079024539 745 128 17 0.1328125 0.0228187919463087
GO:BP GO:0071398 cellular response to fatty acid 0.00224328833226631 43 143 5 0.034965034965035 0.116279069767442
GO:BP GO:0071495 cellular response to endogenous stimulus 0.00231603174062498 1422 122 24 0.19672131147541 0.0168776371308017
GO:BP GO:0014070 response to organic cyclic compound 0.00238998645176577 967 122 19 0.155737704918033 0.0196483971044467
GO:BP GO:0034310 primary alcohol catabolic process 0.00307559083443092 16 72 3 0.0416666666666667 0.1875
GO:BP GO:0048878 chemical homeostasis 0.00331069296258922 1229 117 21 0.179487179487179 0.0170870626525631
GO:BP GO:0006066 alcohol metabolic process 0.00333752875683283 382 117 11 0.094017094017094 0.0287958115183246
GO:BP GO:0071941 nitrogen cycle metabolic process 0.00348877413509728 14 90 3 0.0333333333333333 0.214285714285714
GO:BP GO:0019627 urea metabolic process 0.00348877413509728 14 90 3 0.0333333333333333 0.214285714285714
GO:BP GO:0072329 monocarboxylic acid catabolic process 0.00348877413509728 132 128 7 0.0546875 0.053030303030303
GO:BP GO:0034754 cellular hormone metabolic process 0.00372221483423971 140 84 6 0.0714285714285714 0.0428571428571429
GO:BP GO:0001676 long-chain fatty acid metabolic process 0.00499951347803265 112 111 6 0.0540540540540541 0.0535714285714286
GO:BP GO:0001523 retinoid metabolic process 0.00507596627749292 107 117 6 0.0512820512820513 0.0560747663551402
GO:BP GO:0016053 organic acid biosynthetic process 0.00583462397075562 338 77 8 0.103896103896104 0.0236686390532544
GO:BP GO:0006641 triglyceride metabolic process 0.00583462397075562 113 117 6 0.0512820512820513 0.0530973451327434
GO:BP GO:0016101 diterpenoid metabolic process 0.00583462397075562 113 117 6 0.0512820512820513 0.0530973451327434
GO:BP GO:0032870 cellular response to hormone stimulus 0.00583462397075562 645 120 14 0.116666666666667 0.0217054263565891
GO:BP GO:0006703 estrogen biosynthetic process 0.00583462397075562 13 123 3 0.024390243902439 0.230769230769231
GO:BP GO:1901615 organic hydroxy compound metabolic process 0.00583462397075562 571 117 13 0.111111111111111 0.0227670753064799
GO:BP GO:0019433 triglyceride catabolic process 0.00583462397075562 38 42 3 0.0714285714285714 0.0789473684210526
GO:BP GO:0070365 hepatocyte differentiation 0.00583462397075562 16 99 3 0.0303030303030303 0.1875
GO:BP GO:1901653 cellular response to peptide 0.00615313921755996 408 102 10 0.0980392156862745 0.0245098039215686
GO:BP GO:0034764 positive regulation of transmembrane transport 0.00630166924028106 217 40 5 0.125 0.0230414746543779
GO:BP GO:0034767 positive regulation of ion transmembrane transport 0.00630166924028106 217 40 5 0.125 0.0230414746543779
GO:BP GO:0009062 fatty acid catabolic process 0.00630166924028106 107 128 6 0.046875 0.0560747663551402
GO:BP GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 0.00630166924028106 61 141 5 0.0354609929078014 0.0819672131147541
GO:BP GO:0071375 cellular response to peptide hormone stimulus 0.00659507162106662 340 101 9 0.0891089108910891 0.0264705882352941
GO:BP GO:0042594 response to starvation 0.00659507162106662 202 99 7 0.0707070707070707 0.0346534653465347
GO:BP GO:0009719 response to endogenous stimulus 0.00659525513735584 1683 122 25 0.204918032786885 0.0148544266191325
GO:BP GO:0042592 homeostatic process 0.00660626171077113 1981 117 27 0.230769230769231 0.0136294800605755
GO:BP GO:0022600 digestive system process 0.00669270146013561 102 46 4 0.0869565217391304 0.0392156862745098
GO:BP GO:0070887 cellular response to chemical stimulus 0.00720579218015159 3393 122 40 0.327868852459016 0.0117889773062187
GO:BP GO:0050665 hydrogen peroxide biosynthetic process 0.00720579218015159 17 111 3 0.027027027027027 0.176470588235294
GO:BP GO:0008210 estrogen metabolic process 0.00758119513449172 40 123 4 0.032520325203252 0.1
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.00759135039197656 1227 102 18 0.176470588235294 0.0146699266503667
GO:BP GO:0046461 neutral lipid catabolic process 0.00882389404799365 48 42 3 0.0714285714285714 0.0625
GO:BP GO:0046464 acylglycerol catabolic process 0.00882389404799365 48 42 3 0.0714285714285714 0.0625
GO:BP GO:0006811 ion transport 0.00901656193127702 3661 119 41 0.34453781512605 0.0111991259218793
GO:BP GO:0035773 insulin secretion involved in cellular response to glucose stimulus 0.00908593572966806 69 141 5 0.0354609929078014 0.072463768115942
GO:BP GO:0070542 response to fatty acid 0.00945776046264173 69 77 4 0.051948051948052 0.0579710144927536
GO:BP GO:1901700 response to oxygen-containing compound 0.00994817376406309 1739 102 22 0.215686274509804 0.0126509488211616
GO:BP GO:0098739 import across plasma membrane 0.0104691687959217 163 97 6 0.0618556701030928 0.0368098159509202
GO:BP GO:0009605 response to external stimulus 0.0104691687959217 2944 106 32 0.30188679245283 0.0108695652173913
GO:BP GO:0071417 cellular response to organonitrogen compound 0.0106807518447288 666 143 15 0.104895104895105 0.0225225225225225
GO:BP GO:0043434 response to peptide hormone 0.0106807518447288 462 101 10 0.099009900990099 0.0216450216450216
GO:BP GO:1901652 response to peptide 0.0111038292399042 551 102 11 0.107843137254902 0.0199637023593466
GO:BP GO:0015849 organic acid transport 0.011115981953948 331 116 9 0.0775862068965517 0.027190332326284
GO:BP GO:0051591 response to cAMP 0.011115981953948 97 24 3 0.125 0.0309278350515464
GO:BP GO:0006639 acylglycerol metabolic process 0.0120833900372018 141 117 6 0.0512820512820513 0.0425531914893617
GO:BP GO:0006638 neutral lipid metabolic process 0.0123777032819743 142 117 6 0.0512820512820513 0.0422535211267606
GO:BP GO:0010243 response to organonitrogen compound 0.0125918956428119 1085 143 20 0.13986013986014 0.0184331797235023
GO:BP GO:0032024 positive regulation of insulin secretion 0.0125918956428119 78 141 5 0.0354609929078014 0.0641025641025641
GO:BP GO:0019585 glucuronate metabolic process 0.0125918956428119 25 100 3 0.03 0.12
GO:BP GO:0006063 uronic acid metabolic process 0.0125918956428119 25 100 3 0.03 0.12
GO:BP GO:1903961 positive regulation of anion transmembrane transport 0.0125918956428119 63 96 4 0.0416666666666667 0.0634920634920635
GO:BP GO:0046395 carboxylic acid catabolic process 0.0125918956428119 245 128 8 0.0625 0.0326530612244898
GO:BP GO:0015711 organic anion transport 0.0125918956428119 386 103 9 0.087378640776699 0.0233160621761658
GO:BP GO:0006810 transport 0.0131509426387256 5224 119 52 0.436974789915966 0.00995405819295559
GO:BP GO:0033865 nucleoside bisphosphate metabolic process 0.0134242657846734 141 80 5 0.0625 0.0354609929078014
GO:BP GO:0034032 purine nucleoside bisphosphate metabolic process 0.0134242657846734 141 80 5 0.0625 0.0354609929078014
GO:BP GO:0033875 ribonucleoside bisphosphate metabolic process 0.0134242657846734 141 80 5 0.0625 0.0354609929078014
GO:BP GO:0019216 regulation of lipid metabolic process 0.0134242657846734 419 117 10 0.0854700854700855 0.0238663484486874
GO:BP GO:0140352 export from cell 0.0134767405416343 1418 37 10 0.27027027027027 0.00705218617771509
GO:BP GO:0098719 sodium ion import across plasma membrane 0.0134767405416343 19 141 3 0.0212765957446809 0.157894736842105
GO:BP GO:0071377 cellular response to glucagon stimulus 0.0143429928180165 27 101 3 0.0297029702970297 0.111111111111111
GO:BP GO:0046916 cellular transition metal ion homeostasis 0.0143429928180165 116 56 4 0.0714285714285714 0.0344827586206897
GO:BP GO:0006094 gluconeogenesis 0.0146143610799806 89 131 5 0.0381679389312977 0.0561797752808989
GO:BP GO:1903793 positive regulation of anion transport 0.0149731467491409 504 119 11 0.092436974789916 0.0218253968253968
GO:BP GO:0008610 lipid biosynthetic process 0.0149731467491409 740 137 15 0.109489051094891 0.0202702702702703
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0152035371617703 290 143 9 0.0629370629370629 0.0310344827586207
GO:BP GO:0016054 organic acid catabolic process 0.0152927951368166 262 128 8 0.0625 0.0305343511450382
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 0.0152927951368166 629 82 10 0.121951219512195 0.0158982511923688
GO:BP GO:0019319 hexose biosynthetic process 0.0152927951368166 92 131 5 0.0381679389312977 0.0543478260869565
GO:BP GO:0034220 ion transmembrane transport 0.0152927951368166 1397 60 13 0.216666666666667 0.00930565497494631
GO:BP GO:0034308 primary alcohol metabolic process 0.0152927951368166 95 72 4 0.0555555555555556 0.0421052631578947
GO:BP GO:0042403 thyroid hormone metabolic process 0.0152927951368166 27 106 3 0.0283018867924528 0.111111111111111
GO:BP GO:0046887 positive regulation of hormone secretion 0.0163566867977259 133 141 6 0.0425531914893617 0.0451127819548872
GO:BP GO:1901699 cellular response to nitrogen compound 0.0163566867977259 724 143 15 0.104895104895105 0.0207182320441989
GO:BP GO:0009056 catabolic process 0.0165914370413051 2744 119 32 0.26890756302521 0.0116618075801749
GO:BP GO:0030004 cellular monovalent inorganic cation homeostasis 0.0165914370413051 118 60 4 0.0666666666666667 0.0338983050847458
GO:BP GO:1901575 organic substance catabolic process 0.0165914370413051 2267 119 28 0.235294117647059 0.0123511248345831
GO:BP GO:0009743 response to carbohydrate 0.0165914370413051 243 141 8 0.0567375886524823 0.0329218106995885
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.0165980889207933 306 143 9 0.0629370629370629 0.0294117647058824
GO:BP GO:0051234 establishment of localization 0.0165980889207933 5372 60 30 0.5 0.00558451228592703
GO:BP GO:0033559 unsaturated fatty acid metabolic process 0.0165980889207933 116 111 5 0.045045045045045 0.0431034482758621
GO:BP GO:0055067 monovalent inorganic cation homeostasis 0.0165980889207933 165 77 5 0.0649350649350649 0.0303030303030303
GO:BP GO:0071333 cellular response to glucose stimulus 0.0165980889207933 137 141 6 0.0425531914893617 0.0437956204379562
GO:BP GO:0046503 glycerolipid catabolic process 0.0165980889207933 74 42 3 0.0714285714285714 0.0405405405405405
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0165980889207933 1145 143 20 0.13986013986014 0.0174672489082969
GO:BP GO:0006820 anion transport 0.0165980889207933 2889 128 35 0.2734375 0.0121149186569747
GO:BP GO:0071702 organic substance transport 0.0165980889207933 2766 128 34 0.265625 0.012292118582791
GO:BP GO:0046683 response to organophosphorus 0.0165980889207933 137 141 6 0.0425531914893617 0.0437956204379562
GO:BP GO:0055085 transmembrane transport 0.0165980889207933 1635 60 14 0.233333333333333 0.00856269113149847
GO:BP GO:0050801 ion homeostasis 0.0165980889207933 808 79 11 0.139240506329114 0.0136138613861386
GO:BP GO:0046364 monosaccharide biosynthetic process 0.0165980889207933 98 131 5 0.0381679389312977 0.0510204081632653
GO:BP GO:0006730 one-carbon metabolic process 0.0168217924847443 39 83 3 0.036144578313253 0.0769230769230769
GO:BP GO:0055082 cellular chemical homeostasis 0.0169953518505537 841 65 10 0.153846153846154 0.0118906064209275
GO:BP GO:0071331 cellular response to hexose stimulus 0.0169953518505537 139 141 6 0.0425531914893617 0.0431654676258993
GO:BP GO:0071326 cellular response to monosaccharide stimulus 0.017360213039037 140 141 6 0.0425531914893617 0.0428571428571429
GO:BP GO:0006805 xenobiotic metabolic process 0.0176556576513115 122 108 5 0.0462962962962963 0.040983606557377
GO:BP GO:1901698 response to nitrogen compound 0.0176556576513115 1172 102 16 0.156862745098039 0.0136518771331058
GO:BP GO:0055076 transition metal ion homeostasis 0.018208556087484 138 56 4 0.0714285714285714 0.0289855072463768
GO:BP GO:0046903 secretion 0.0186602315845272 1501 52 12 0.230769230769231 0.00799467021985343
GO:BP GO:0042572 retinol metabolic process 0.0186602315845272 48 72 3 0.0416666666666667 0.0625
GO:BP GO:0008217 regulation of blood pressure 0.0186602315845272 193 105 6 0.0571428571428571 0.0310880829015544
GO:BP GO:0006163 purine nucleotide metabolic process 0.0193418671510782 450 82 8 0.0975609756097561 0.0177777777777778
GO:BP GO:0099587 inorganic ion import across plasma membrane 0.0193418671510782 97 141 5 0.0354609929078014 0.0515463917525773
GO:BP GO:0098659 inorganic cation import across plasma membrane 0.0193418671510782 97 141 5 0.0354609929078014 0.0515463917525773
GO:BP GO:0006885 regulation of pH 0.0193418671510782 103 77 4 0.051948051948052 0.0388349514563107
GO:BP GO:0071466 cellular response to xenobiotic stimulus 0.0193556555642047 127 108 5 0.0462962962962963 0.0393700787401575
GO:BP GO:0009749 response to glucose 0.0193689475743163 202 102 6 0.0588235294117647 0.0297029702970297
GO:BP GO:0006690 icosanoid metabolic process 0.0193689475743163 124 111 5 0.045045045045045 0.0403225806451613
GO:BP GO:0031667 response to nutrient levels 0.0193689475743163 482 77 8 0.103896103896104 0.016597510373444
GO:BP GO:0019395 fatty acid oxidation 0.0195679697401892 108 128 5 0.0390625 0.0462962962962963
GO:BP GO:0014074 response to purine-containing compound 0.0197357927893993 152 24 3 0.125 0.0197368421052632
GO:BP GO:0043270 positive regulation of ion transport 0.0199290678175628 694 141 14 0.099290780141844 0.0201729106628242
GO:BP GO:0071322 cellular response to carbohydrate stimulus 0.0201737740751255 148 141 6 0.0425531914893617 0.0405405405405405
GO:BP GO:0043312 neutrophil degranulation 0.0201970023132414 482 30 5 0.166666666666667 0.0103734439834025
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0201970023132414 485 30 5 0.166666666666667 0.0103092783505155
GO:BP GO:0009725 response to hormone 0.0203371861988723 921 120 15 0.125 0.0162866449511401
GO:BP GO:0051179 localization 0.0203371861988723 6901 132 68 0.515151515151515 0.00985364439936241
GO:BP GO:0006879 cellular iron ion homeostasis 0.020529341075785 69 54 3 0.0555555555555556 0.0434782608695652
GO:BP GO:0010038 response to metal ion 0.020666627933632 371 58 6 0.103448275862069 0.0161725067385445
GO:BP GO:0009746 response to hexose 0.020666627933632 209 102 6 0.0588235294117647 0.0287081339712919
GO:BP GO:0140448 signaling receptor ligand precursor processing 0.020666627933632 36 105 3 0.0285714285714286 0.0833333333333333
GO:BP GO:0003013 circulatory system process 0.020666627933632 637 105 11 0.104761904761905 0.0172684458398744
GO:BP GO:0033762 response to glucagon 0.0211015245715575 38 101 3 0.0297029702970297 0.0789473684210526
GO:BP GO:0009410 response to xenobiotic stimulus 0.0211015245715575 134 108 5 0.0462962962962963 0.0373134328358209
GO:BP GO:0042119 neutrophil activation 0.0211015245715575 498 30 5 0.166666666666667 0.0100401606425703
GO:BP GO:0034440 lipid oxidation 0.0211015245715575 113 128 5 0.0390625 0.0442477876106195
GO:BP GO:0002446 neutrophil mediated immunity 0.0211015245715575 497 30 5 0.166666666666667 0.0100603621730382
GO:BP GO:1901605 alpha-amino acid metabolic process 0.0212344134183972 198 110 6 0.0545454545454545 0.0303030303030303
GO:BP GO:0034612 response to tumor necrosis factor 0.0212344134183972 331 143 9 0.0629370629370629 0.027190332326284
GO:BP GO:0090277 positive regulation of peptide hormone secretion 0.0212344134183972 103 141 5 0.0354609929078014 0.0485436893203883
GO:BP GO:0036230 granulocyte activation 0.0212344134183972 504 30 5 0.166666666666667 0.00992063492063492
GO:BP GO:0031669 cellular response to nutrient levels 0.0212344134183972 219 99 6 0.0606060606060606 0.0273972602739726
GO:BP GO:0050892 intestinal absorption 0.0212344134183972 40 97 3 0.0309278350515464 0.075
GO:BP GO:0072521 purine-containing compound metabolic process 0.0213260021956693 473 82 8 0.0975609756097561 0.0169133192389006
GO:BP GO:0034284 response to monosaccharide 0.021601835270481 215 102 6 0.0588235294117647 0.027906976744186
GO:BP GO:0001990 regulation of systemic arterial blood pressure by hormone 0.0217355173305535 38 105 3 0.0285714285714286 0.0789473684210526
GO:BP GO:0042446 hormone biosynthetic process 0.0217377422656909 71 123 4 0.032520325203252 0.0563380281690141
GO:BP GO:0033993 response to lipid 0.0218780443778909 918 123 15 0.121951219512195 0.0163398692810458
GO:BP GO:0042221 response to chemical 0.0221179653405894 4781 123 48 0.390243902439024 0.0100397406400335
GO:BP GO:0001678 cellular glucose homeostasis 0.0221179653405894 157 141 6 0.0425531914893617 0.0382165605095541
GO:BP GO:0009991 response to extracellular stimulus 0.0222832555618522 512 77 8 0.103896103896104 0.015625
GO:BP GO:0030073 insulin secretion 0.0222832555618522 218 102 6 0.0588235294117647 0.0275229357798165
GO:BP GO:0055080 cation homeostasis 0.0228320372031936 750 79 10 0.126582278481013 0.0133333333333333
GO:BP GO:0048844 artery morphogenesis 0.0232469214901951 77 117 4 0.0341880341880342 0.051948051948052
GO:BP GO:0098657 import into cell 0.0234890247167323 235 97 6 0.0618556701030928 0.025531914893617
GO:BP GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 0.0234890247167323 63 67 3 0.0447761194029851 0.0476190476190476
GO:BP GO:0046164 alcohol catabolic process 0.0234890247167323 58 72 3 0.0416666666666667 0.0517241379310345
GO:BP GO:0030003 cellular cation homeostasis 0.0234890247167323 673 60 8 0.133333333333333 0.011887072808321
GO:BP GO:0098771 inorganic ion homeostasis 0.0237455963959161 761 79 10 0.126582278481013 0.0131406044678055
GO:BP GO:0072676 lymphocyte migration 0.0237455963959161 117 79 4 0.0506329113924051 0.0341880341880342
GO:BP GO:0043299 leukocyte degranulation 0.0237455963959161 535 30 5 0.166666666666667 0.00934579439252336
GO:BP GO:0050727 regulation of inflammatory response 0.0239830503518388 381 106 8 0.0754716981132075 0.020997375328084
GO:BP GO:0006873 cellular ion homeostasis 0.02448279453938 687 60 8 0.133333333333333 0.0116448326055313
GO:BP GO:0009267 cellular response to starvation 0.0245371804123436 160 99 5 0.0505050505050505 0.03125
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0247898726165467 547 30 5 0.166666666666667 0.00914076782449726
GO:BP GO:0050873 brown fat cell differentiation 0.0251172433133479 49 91 3 0.032967032967033 0.0612244897959184
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0252833790505499 551 30 5 0.166666666666667 0.00907441016333938
GO:BP GO:0071496 cellular response to external stimulus 0.0252833790505499 322 99 7 0.0707070707070707 0.0217391304347826
GO:BP GO:0071407 cellular response to organic cyclic compound 0.0264484242128729 587 122 11 0.0901639344262295 0.0187393526405451
GO:BP GO:1903959 regulation of anion transmembrane transport 0.0266139247151742 115 40 3 0.075 0.0260869565217391
GO:BP GO:0046879 hormone secretion 0.0266420099716535 317 102 7 0.0686274509803922 0.0220820189274448
GO:BP GO:0031960 response to corticosteroid 0.0266420099716535 165 99 5 0.0505050505050505 0.0303030303030303
GO:BP GO:0055072 iron ion homeostasis 0.0269505852598385 86 54 3 0.0555555555555556 0.0348837209302326
GO:BP GO:0009259 ribonucleotide metabolic process 0.0279711800052773 431 143 10 0.0699300699300699 0.0232018561484919
GO:BP GO:0048545 response to steroid hormone 0.0280796179839745 349 120 8 0.0666666666666667 0.0229226361031519
GO:BP GO:0010035 response to inorganic substance 0.0283598231356128 575 58 7 0.120689655172414 0.0121739130434783
GO:BP GO:1903053 regulation of extracellular matrix organization 0.028494864469092 47 102 3 0.0294117647058824 0.0638297872340425
GO:BP GO:0044248 cellular catabolic process 0.028494864469092 2347 119 27 0.226890756302521 0.0115040477204942
GO:BP GO:0098660 inorganic ion transmembrane transport 0.028494864469092 883 60 9 0.15 0.0101925254813137
GO:BP GO:0031668 cellular response to extracellular stimulus 0.0289835405906508 248 99 6 0.0606060606060606 0.0241935483870968
GO:BP GO:0006790 sulfur compound metabolic process 0.0293078838330789 386 110 8 0.0727272727272727 0.0207253886010363
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0293078838330789 783 14 4 0.285714285714286 0.00510855683269476
GO:BP GO:0019725 cellular homeostasis 0.0293078838330789 981 65 10 0.153846153846154 0.0101936799184506
GO:BP GO:1901570 fatty acid derivative biosynthetic process 0.0294044592501675 61 80 3 0.0375 0.0491803278688525
GO:BP GO:0071310 cellular response to organic substance 0.0294487446153845 2776 102 27 0.264705882352941 0.00972622478386167
GO:BP GO:0009914 hormone transport 0.0294487446153845 327 102 7 0.0686274509803922 0.0214067278287462
GO:BP GO:0008015 blood circulation 0.0300969613291105 553 32 5 0.15625 0.00904159132007233
GO:BP GO:0048247 lymphocyte chemotaxis 0.0300969613291105 63 79 3 0.0379746835443038 0.0476190476190476
GO:BP GO:0019693 ribose phosphate metabolic process 0.0300969613291105 441 143 10 0.0699300699300699 0.0226757369614512
GO:BP GO:0009150 purine ribonucleotide metabolic process 0.0304206230588123 414 82 7 0.0853658536585366 0.0169082125603865
GO:BP GO:0072348 sulfur compound transport 0.0305130968748952 49 103 3 0.029126213592233 0.0612244897959184
GO:BP GO:0046394 carboxylic acid biosynthetic process 0.0312626678744333 330 77 6 0.0779220779220779 0.0181818181818182
GO:BP GO:0062012 regulation of small molecule metabolic process 0.0319766283033064 447 77 7 0.0909090909090909 0.0156599552572707
GO:BP GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 0.0332093844054401 50 105 3 0.0285714285714286 0.06
GO:BP GO:0034030 ribonucleoside bisphosphate biosynthetic process 0.0332093844054401 68 77 3 0.038961038961039 0.0441176470588235
GO:BP GO:0034033 purine nucleoside bisphosphate biosynthetic process 0.0332093844054401 68 77 3 0.038961038961039 0.0441176470588235
GO:BP GO:0033866 nucleoside bisphosphate biosynthetic process 0.0332093844054401 68 77 3 0.038961038961039 0.0441176470588235
GO:BP GO:0009117 nucleotide metabolic process 0.0343880515884634 544 82 8 0.0975609756097561 0.0147058823529412
GO:BP GO:0051453 regulation of intracellular pH 0.0343880515884634 89 60 3 0.05 0.0337078651685393
GO:BP GO:0062013 positive regulation of small molecule metabolic process 0.0344702711948418 145 76 4 0.0526315789473684 0.0275862068965517
GO:BP GO:0032101 regulation of response to external stimulus 0.0344702711948418 1051 106 14 0.132075471698113 0.0133206470028544
GO:BP GO:0008203 cholesterol metabolic process 0.0345065827983273 154 117 5 0.0427350427350427 0.0324675324675325
GO:BP GO:0010033 response to organic substance 0.0345325297146423 3412 123 36 0.292682926829268 0.0105509964830012
GO:BP GO:1903018 regulation of glycoprotein metabolic process 0.0345325297146423 62 87 3 0.0344827586206897 0.0483870967741935
GO:BP GO:0002274 myeloid leukocyte activation 0.0351145450552485 667 9 3 0.333333333333333 0.00449775112443778
GO:BP GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 0.0351145450552485 46 119 3 0.0252100840336134 0.0652173913043478
GO:BP GO:0030072 peptide hormone secretion 0.0351145450552485 260 102 6 0.0588235294117647 0.0230769230769231
GO:BP GO:0006753 nucleoside phosphate metabolic process 0.0351431242358107 555 82 8 0.0975609756097561 0.0144144144144144
GO:BP GO:0050796 regulation of insulin secretion 0.0353857123041126 189 141 6 0.0425531914893617 0.0317460317460317
GO:BP GO:0030641 regulation of cellular pH 0.0365578779301893 95 60 3 0.05 0.0315789473684211
GO:BP GO:0042632 cholesterol homeostasis 0.0366504127174549 99 117 4 0.0341880341880342 0.0404040404040404
GO:BP GO:0009636 response to toxic substance 0.036880134556839 243 24 3 0.125 0.0123456790123457
GO:BP GO:0006869 lipid transport 0.0370397395096402 480 117 9 0.0769230769230769 0.01875
GO:BP GO:1901616 organic hydroxy compound catabolic process 0.0370744685076604 80 72 3 0.0416666666666667 0.0375
GO:BP GO:0052126 movement in host environment 0.0372582368882329 177 107 5 0.0467289719626168 0.0282485875706215
GO:BP GO:0055092 sterol homeostasis 0.0372582368882329 100 117 4 0.0341880341880342 0.04
GO:BP GO:0001558 regulation of cell growth 0.0372582368882329 426 132 9 0.0681818181818182 0.0211267605633803
GO:BP GO:0098656 anion transmembrane transport 0.0379232680415008 550 103 9 0.087378640776699 0.0163636363636364
GO:BP GO:0050714 positive regulation of protein secretion 0.0386074840248885 136 141 5 0.0354609929078014 0.0367647058823529
GO:BP GO:1902652 secondary alcohol metabolic process 0.0386074840248885 164 117 5 0.0427350427350427 0.0304878048780488
GO:BP GO:0051222 positive regulation of protein transport 0.0387098565594476 329 141 8 0.0567375886524823 0.0243161094224924
GO:BP GO:0060840 artery development 0.0390505778568266 102 117 4 0.0341880341880342 0.0392156862745098
GO:BP GO:0002366 leukocyte activation involved in immune response 0.039103977066738 717 9 3 0.333333333333333 0.00418410041841004
GO:BP GO:0006006 glucose metabolic process 0.03914646680416 211 131 6 0.0458015267175573 0.028436018957346
GO:BP GO:0002263 cell activation involved in immune response 0.0392590731844593 721 9 3 0.333333333333333 0.00416088765603329
GO:BP GO:1900371 regulation of purine nucleotide biosynthetic process 0.0392590731844593 42 143 3 0.020979020979021 0.0714285714285714
GO:BP GO:0019318 hexose metabolic process 0.039551262837823 253 146 7 0.0479452054794521 0.0276679841897233
GO:BP GO:0044070 regulation of anion transport 0.039575596546525 896 102 12 0.117647058823529 0.0133928571428571
GO:BP GO:0032940 secretion by cell 0.0399798724760022 1364 36 8 0.222222222222222 0.00586510263929619
GO:BP GO:0055088 lipid homeostasis 0.0399843794913396 167 117 5 0.0427350427350427 0.029940119760479
GO:BP GO:0071827 plasma lipoprotein particle organization 0.0399962664463703 52 117 3 0.0256410256410256 0.0576923076923077
GO:BP GO:0051050 positive regulation of transport 0.0399962664463703 923 75 10 0.133333333333333 0.0108342361863489
GO:BP GO:0046883 regulation of hormone secretion 0.0400459616997196 275 102 6 0.0588235294117647 0.0218181818181818
GO:BP GO:0042743 hydrogen peroxide metabolic process 0.0401191704379001 55 111 3 0.027027027027027 0.0545454545454545
GO:BP GO:0016051 carbohydrate biosynthetic process 0.0401191704379001 214 131 6 0.0458015267175573 0.0280373831775701
GO:BP GO:0030808 regulation of nucleotide biosynthetic process 0.0403998356311317 43 143 3 0.020979020979021 0.0697674418604651
GO:BP GO:0120178 steroid hormone biosynthetic process 0.0405188159056166 50 123 3 0.024390243902439 0.06
GO:BP GO:0071384 cellular response to corticosteroid stimulus 0.041356376532747 63 99 3 0.0303030303030303 0.0476190476190476
GO:BP GO:0016125 sterol metabolic process 0.0420048249239009 171 117 5 0.0427350427350427 0.0292397660818713
GO:BP GO:0034765 regulation of ion transmembrane transport 0.0426802377601658 583 50 6 0.12 0.0102915951972556
GO:BP GO:0034762 regulation of transmembrane transport 0.0440020128067234 588 50 6 0.12 0.0102040816326531
GO:BP GO:1901654 response to ketone 0.0440020128067234 204 32 3 0.09375 0.0147058823529412
GO:BP GO:0003014 renal system process 0.0440020128067234 126 101 4 0.0396039603960396 0.0317460317460317
GO:BP GO:1901568 fatty acid derivative metabolic process 0.0440020128067234 81 80 3 0.0375 0.037037037037037
GO:BP GO:0045055 regulated exocytosis 0.0440020128067234 785 9 3 0.333333333333333 0.00382165605095541
GO:BP GO:0032868 response to insulin 0.0440020128067234 295 99 6 0.0606060606060606 0.0203389830508475
GO:BP GO:1904951 positive regulation of establishment of protein localization 0.0440653497455165 345 141 8 0.0567375886524823 0.0231884057971014
GO:BP GO:0071825 protein-lipid complex subunit organization 0.0441257615399361 56 117 3 0.0256410256410256 0.0535714285714286
GO:BP GO:0044262 cellular carbohydrate metabolic process 0.044200394699607 296 99 6 0.0606060606060606 0.0202702702702703
GO:BP GO:0051604 protein maturation 0.0448663136093574 306 127 7 0.0551181102362205 0.0228758169934641
GO:BP GO:0042180 cellular ketone metabolic process 0.0451744001045429 271 77 5 0.0649350649350649 0.018450184501845
GO:BP GO:0009306 protein secretion 0.0454778825475937 384 102 7 0.0686274509803922 0.0182291666666667
GO:BP GO:0035592 establishment of protein localization to extracellular region 0.0456918345228324 385 102 7 0.0686274509803922 0.0181818181818182
GO:BP GO:0006979 response to oxidative stress 0.0456918345228324 466 29 4 0.137931034482759 0.00858369098712446
GO:BP GO:1901617 organic hydroxy compound biosynthetic process 0.0456918345228324 254 117 6 0.0512820512820513 0.0236220472440945
GO:BP GO:1905954 positive regulation of lipid localization 0.0457700463795316 113 117 4 0.0341880341880342 0.0353982300884956
GO:BP GO:0097345 mitochondrial outer membrane permeabilization 0.0460279887939996 57 119 3 0.0252100840336134 0.0526315789473684
GO:BP GO:0016485 protein processing 0.0460927913414033 235 127 6 0.047244094488189 0.025531914893617
GO:BP GO:0032496 response to lipopolysaccharide 0.0461196163852354 338 117 7 0.0598290598290598 0.0207100591715976
GO:BP GO:0050708 regulation of protein secretion 0.0465190569240503 295 102 6 0.0588235294117647 0.0203389830508475
GO:BP GO:0044272 sulfur compound biosynthetic process 0.0465190569240503 193 110 5 0.0454545454545455 0.0259067357512953
GO:BP GO:0090087 regulation of peptide transport 0.0467739597857106 618 65 7 0.107692307692308 0.0113268608414239
GO:BP GO:0046942 carboxylic acid transport 0.0470073770771142 294 103 6 0.058252427184466 0.0204081632653061
GO:BP GO:0071692 protein localization to extracellular region 0.047071422163369 392 102 7 0.0686274509803922 0.0178571428571429
GO:BP GO:0046718 viral entry into host cell 0.0471420398225059 141 96 4 0.0416666666666667 0.0283687943262411
GO:BP GO:0019637 organophosphate metabolic process 0.0485569630531498 1041 82 11 0.134146341463415 0.010566762728146
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0485569630531498 2255 121 25 0.206611570247934 0.0110864745011086
GO:BP GO:0034103 regulation of tissue remodeling 0.0485569630531498 92 77 3 0.038961038961039 0.0326086956521739
GO:BP GO:0061041 regulation of wound healing 0.0485569630531498 136 52 3 0.0576923076923077 0.0220588235294118
GO:BP GO:0005996 monosaccharide metabolic process 0.0485569630531498 276 146 7 0.0479452054794521 0.0253623188405797
GO:BP GO:0010876 lipid localization 0.0494541494299619 530 117 9 0.0769230769230769 0.0169811320754717
GO:CC GO:0070062 extracellular exosome 2.76989886713155e-10 2176 121 44 0.363636363636364 0.0202205882352941
GO:CC GO:0043230 extracellular organelle 3.57396873596839e-10 2263 121 44 0.363636363636364 0.0194432169686257
GO:CC GO:1903561 extracellular vesicle 3.57396873596839e-10 2261 121 44 0.363636363636364 0.0194604157452455
GO:CC GO:0005903 brush border 1.58591645899875e-09 107 105 11 0.104761904761905 0.102803738317757
GO:CC GO:0005615 extracellular space 1.83876539143219e-08 3594 121 53 0.43801652892562 0.0147468002225932
GO:CC GO:0005576 extracellular region 1.83876539143219e-08 4567 121 61 0.504132231404959 0.0133566892927524
GO:CC GO:0031526 brush border membrane 5.2502439837682e-08 59 103 8 0.0776699029126214 0.135593220338983
GO:CC GO:0098862 cluster of actin-based cell projections 7.10890778925641e-08 162 105 11 0.104761904761905 0.0679012345679012
GO:CC GO:0045177 apical part of cell 6.92883484240216e-07 431 106 15 0.141509433962264 0.0348027842227378
GO:CC GO:0031982 vesicle 7.42926387724785e-06 4055 121 51 0.421487603305785 0.012577065351418
GO:CC GO:0098590 plasma membrane region 3.10185096324266e-05 1240 105 22 0.20952380952381 0.017741935483871
GO:CC GO:0016324 apical plasma membrane 0.000155713532561181 361 105 11 0.104761904761905 0.0304709141274238
GO:CC GO:0005886 plasma membrane 0.000188219039664075 5681 107 54 0.504672897196262 0.00950536877310333
GO:CC GO:0031253 cell projection membrane 0.000422636040536808 343 103 10 0.0970873786407767 0.0291545189504373
GO:CC GO:0071944 cell periphery 0.000422636040536808 6169 107 56 0.523364485981308 0.00907764629599611
GO:CC GO:0030141 secretory granule 0.00666055371025577 851 30 7 0.233333333333333 0.0082256169212691
GO:CC GO:0016323 basolateral plasma membrane 0.0105285483045494 222 56 5 0.0892857142857143 0.0225225225225225
GO:CC GO:0031224 intrinsic component of membrane 0.0124557698351434 5868 75 37 0.493333333333333 0.00630538513974097
GO:CC GO:0009925 basal plasma membrane 0.0144968900807474 247 56 5 0.0892857142857143 0.0202429149797571
GO:CC GO:0099503 secretory vesicle 0.0146139476465041 1020 30 7 0.233333333333333 0.00686274509803922
GO:CC GO:0005902 microvillus 0.0146139476465041 91 89 4 0.0449438202247191 0.043956043956044
GO:CC GO:0005774 vacuolar membrane 0.0146560233280161 441 130 10 0.0769230769230769 0.0226757369614512
GO:CC GO:0045178 basal part of cell 0.0165426927029738 265 56 5 0.0892857142857143 0.0188679245283019
GO:CC GO:0097225 sperm midpiece 0.0166559005205621 31 127 3 0.0236220472440945 0.0967741935483871
GO:CC GO:0016021 integral component of membrane 0.0173119906014944 5711 106 47 0.443396226415094 0.00822973209595517
GO:CC GO:0005773 vacuole 0.0173119906014944 810 130 14 0.107692307692308 0.0172839506172839
GO:CC GO:0016020 membrane 0.0175181897189864 9838 60 43 0.716666666666667 0.00437080707460866
GO:CC GO:0009986 cell surface 0.0278558219323527 899 21 5 0.238095238095238 0.00556173526140156
GO:CC GO:0005811 lipid droplet 0.0278558219323527 95 117 4 0.0341880341880342 0.0421052631578947
GO:CC GO:0012505 endomembrane system 0.0302275994985251 4640 123 44 0.357723577235772 0.00948275862068966
GO:CC GO:0005783 endoplasmic reticulum 0.0333014424492238 1982 144 26 0.180555555555556 0.0131180625630676
GO:CC GO:0030667 secretory granule membrane 0.0341703293745159 303 21 3 0.142857142857143 0.0099009900990099
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0343885973614955 1726 43 10 0.232558139534884 0.00579374275782155
GO:CC GO:0098852 lytic vacuole membrane 0.0365087641789327 383 130 8 0.0615384615384615 0.02088772845953
GO:CC GO:0005765 lysosomal membrane 0.0365087641789327 383 130 8 0.0615384615384615 0.02088772845953
GO:CC GO:1904724 tertiary granule lumen 0.0444539661836681 55 131 3 0.0229007633587786 0.0545454545454545
GO:MF GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 6.32155795514882e-05 125 123 9 0.0731707317073171 0.072
GO:MF GO:0016614 oxidoreductase activity, acting on CH-OH group of donors 6.32155795514882e-05 137 123 9 0.0731707317073171 0.0656934306569343
GO:MF GO:0033293 monocarboxylic acid binding 6.32155795514882e-05 74 111 7 0.0630630630630631 0.0945945945945946
GO:MF GO:0031406 carboxylic acid binding 0.000140827210352994 194 128 10 0.078125 0.0515463917525773
GO:MF GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 0.00017655760064197 30 123 5 0.040650406504065 0.166666666666667
GO:MF GO:0016229 steroid dehydrogenase activity 0.000326460230159194 35 123 5 0.040650406504065 0.142857142857143
GO:MF GO:0005504 fatty acid binding 0.000333899188689763 40 111 5 0.045045045045045 0.125
GO:MF GO:0016491 oxidoreductase activity 0.000410873174857075 771 128 18 0.140625 0.0233463035019455
GO:MF GO:0032052 bile acid binding 0.000447636169032111 11 65 3 0.0461538461538462 0.272727272727273
GO:MF GO:0004089 carbonate dehydratase activity 0.00208520048899381 15 83 3 0.036144578313253 0.2
GO:MF GO:0003824 catalytic activity 0.00375791873690762 5896 112 55 0.491071428571429 0.00932835820895522
GO:MF GO:0004303 estradiol 17-beta-dehydrogenase activity 0.00425484801803852 14 123 3 0.024390243902439 0.214285714285714
GO:MF GO:0016836 hydro-lyase activity 0.0171287130529798 65 110 4 0.0363636363636364 0.0615384615384615
GO:MF GO:0042379 chemokine receptor binding 0.0220960948097391 72 121 4 0.0330578512396694 0.0555555555555556
GO:MF GO:0016835 carbon-oxygen lyase activity 0.0220960948097391 81 110 4 0.0363636363636364 0.0493827160493827
GO:MF GO:0008009 chemokine activity 0.0220960948097391 49 79 3 0.0379746835443038 0.0612244897959184
GO:MF GO:0016829 lyase activity 0.0220960948097391 203 110 6 0.0545454545454545 0.0295566502463054
GO:MF GO:0015318 inorganic molecular entity transmembrane transporter activity 0.0220960948097391 831 60 9 0.15 0.0108303249097473
GO:MF GO:1901682 sulfur compound transmembrane transporter activity 0.0263667748333977 47 103 3 0.029126213592233 0.0638297872340425
GO:MF GO:0048029 monosaccharide binding 0.0266542594329781 71 146 4 0.0273972602739726 0.0563380281690141
GO:MF GO:0008238 exopeptidase activity 0.0266542594329781 95 109 4 0.036697247706422 0.0421052631578947
GO:MF GO:0015297 antiporter activity 0.0266794322447358 84 60 3 0.05 0.0357142857142857
GO:MF GO:0051287 NAD binding 0.0270815360748887 55 100 3 0.03 0.0545454545454545
GO:MF GO:0015075 ion transmembrane transporter activity 0.0273737564203068 956 60 9 0.15 0.00941422594142259
GO:MF GO:0008270 zinc ion binding 0.0283169122192167 833 110 12 0.109090909090909 0.014405762304922
GO:MF GO:0048020 CCR chemokine receptor binding 0.0283538807688541 48 121 3 0.0247933884297521 0.0625
GO:MF GO:0008289 lipid binding 0.030779799358642 776 120 12 0.1 0.0154639175257732
GO:MF GO:0022853 active ion transmembrane transporter activity 0.0331360002319614 213 60 4 0.0666666666666667 0.0187793427230047
GO:MF GO:0008235 metalloexopeptidase activity 0.0339180689923877 63 105 3 0.0285714285714286 0.0476190476190476
GO:MF GO:0043168 anion binding 0.038641211089017 2418 111 24 0.216216216216216 0.00992555831265509
GO:MF GO:0022857 transmembrane transporter activity 0.038641211089017 1075 60 9 0.15 0.00837209302325581
GO:MF GO:0005342 organic acid transmembrane transporter activity 0.038641211089017 154 49 3 0.0612244897959184 0.0194805194805195
GO:MF GO:0046943 carboxylic acid transmembrane transporter activity 0.038641211089017 153 49 3 0.0612244897959184 0.0196078431372549
GO:MF GO:0036094 small molecule binding 0.038641211089017 2506 118 26 0.220338983050847 0.0103750997605746
GO:MF GO:0005509 calcium ion binding 0.0392774672964495 721 33 5 0.151515151515152 0.00693481276005548
GO:MF GO:0005179 hormone activity 0.0393374934359393 127 61 3 0.0491803278688525 0.0236220472440945
GO:MF GO:0042277 peptide binding 0.0401839560047931 314 105 6 0.0571428571428571 0.0191082802547771
GO:MF GO:0046914 transition metal ion binding 0.0408663675393796 1111 140 16 0.114285714285714 0.0144014401440144
GO:MF GO:0001540 amyloid-beta binding 0.0415180445527682 83 102 3 0.0294117647058824 0.036144578313253
GO:MF GO:0048018 receptor ligand activity 0.0426791079905476 494 92 7 0.0760869565217391 0.01417004048583
GO:MF GO:0022890 inorganic cation transmembrane transporter activity 0.0436445539926431 591 60 6 0.1 0.0101522842639594
GO:MF GO:0030546 signaling receptor activator activity 0.0441807859972556 501 92 7 0.0760869565217391 0.0139720558882236
GO:MF GO:0099106 ion channel regulator activity 0.045469364820544 120 75 3 0.04 0.025
GO:MF GO:0046873 metal ion transmembrane transporter activity 0.046115930632824 435 60 5 0.0833333333333333 0.0114942528735632
GO:MF GO:0042802 identical protein binding 0.0463923175273161 2067 121 22 0.181818181818182 0.0106434446057088
HPA HPA:0480053 small intestine; glandular cells[High] 0.00159888051132661 2723 125 55 0.44 0.0201983106867426
KEGG KEGG:04976 Bile secretion 0.000340762976224669 90 101 9 0.0891089108910891 0.1
KEGG KEGG:04964 Proximal tubule bicarbonate reclamation 0.000731500124612032 23 99 5 0.0505050505050505 0.217391304347826
KEGG KEGG:00910 Nitrogen metabolism 0.00152616919590899 17 83 4 0.0481927710843374 0.235294117647059
KEGG KEGG:00040 Pentose and glucuronate interconversions 0.00284960597940168 34 100 5 0.05 0.147058823529412
KEGG KEGG:04978 Mineral absorption 0.0028875251149198 59 97 6 0.0618556701030928 0.101694915254237
KEGG KEGG:03320 PPAR signaling pathway 0.00325894884980121 75 116 7 0.0603448275862069 0.0933333333333333
KEGG KEGG:04614 Renin-angiotensin system 0.00668626851515255 23 109 4 0.036697247706422 0.173913043478261
KEGG KEGG:00140 Steroid hormone biosynthesis 0.00734533692946726 60 123 6 0.0487804878048781 0.1
KEGG KEGG:00052 Galactose metabolism 0.0337256434586919 31 131 4 0.0305343511450382 0.129032258064516
REAC REAC:R-HSA-1247673 Erythrocytes take up oxygen and release carbon dioxide 0.00383124734002865 7 83 3 0.036144578313253 0.428571428571429
REAC REAC:R-HSA-211859 Biological oxidations 0.00383124734002865 215 69 9 0.130434782608696 0.0418604651162791
REAC REAC:R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 0.00882725343073867 11 83 3 0.036144578313253 0.272727272727273
REAC REAC:R-HSA-1480926 O2/CO2 exchange in erythrocytes 0.00882725343073867 11 83 3 0.036144578313253 0.272727272727273
REAC REAC:R-HSA-1475029 Reversible hydration of carbon dioxide 0.00936226907624161 12 83 3 0.036144578313253 0.25
REAC REAC:R-HSA-975634 Retinoid metabolism and transport 0.00941986030137382 44 117 5 0.0427350427350427 0.113636363636364
REAC REAC:R-HSA-1430728 Metabolism 0.00970866388346737 2070 117 40 0.341880341880342 0.0193236714975845
REAC REAC:R-HSA-6806667 Metabolism of fat-soluble vitamins 0.0107526525997347 48 117 5 0.0427350427350427 0.104166666666667
REAC REAC:R-HSA-8979227 Triglyceride metabolism 0.0196414994687884 38 101 4 0.0396039603960396 0.105263157894737
REAC REAC:R-HSA-382551 Transport of small molecules 0.0196414994687884 718 103 17 0.16504854368932 0.0236768802228412
REAC REAC:R-HSA-156580 Phase II - Conjugation of compounds 0.0196414994687884 104 69 5 0.072463768115942 0.0480769230769231
REAC REAC:R-HSA-156588 Glucuronidation 0.0196414994687884 23 69 3 0.0434782608695652 0.130434782608696
REAC REAC:R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 0.020900280795251 18 105 3 0.0285714285714286 0.166666666666667
REAC REAC:R-HSA-8963743 Digestion and absorption 0.0351209979680892 24 97 3 0.0309278350515464 0.125
REAC REAC:R-HSA-163560 Triglyceride catabolism 0.0373838966249579 24 101 3 0.0297029702970297 0.125
REAC REAC:R-HSA-5619102 SLC transporter disorders 0.0451484397230294 96 103 5 0.0485436893203883 0.0520833333333333
REAC REAC:R-HSA-425407 SLC-mediated transmembrane transport 0.0468565453434495 248 60 6 0.1 0.0241935483870968
REAC REAC:R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 0.0468565453434495 105 60 4 0.0666666666666667 0.0380952380952381
TF TF:M00924 Factor: AP-1; motif: TGACTCANNSKN 0.00869479928544621 2801 104 34 0.326923076923077 0.0121385219564441
TF TF:M01003_1 Factor: Helios; motif: NNTWGGGANNN; match class: 1 0.00869479928544621 420 88 11 0.125 0.0261904761904762
TF TF:M01147 Factor: DMRT2; motif: NAWWTTGWTACATTGW 0.0104903960984759 200 12 4 0.333333333333333 0.02
TF TF:M02013 Factor: HNF-1alpha; motif: RGTTAATNWTT 0.023096745710158 1522 69 17 0.246376811594203 0.0111695137976347
TF TF:M00132 Factor: HNF-1alpha; motif: GGTTAATNWTTAMCN 0.0267317166378819 840 29 8 0.275862068965517 0.00952380952380952
TF TF:M02104 Factor: NF-E2; motif: CATGACTCAGCANNCN 0.0312639376554237 1146 104 18 0.173076923076923 0.0157068062827225
TF TF:M11774_1 Factor: RXR-alpha; motif: RRGGTCAAAGGTCAN; match class: 1 0.0321336829347185 1000 99 16 0.161616161616162 0.016
TF TF:M00162_1 Factor: Oct-1; motif: CWNAWTKWSATRYN; match class: 1 0.0321336829347185 444 57 8 0.140350877192982 0.018018018018018
TF TF:M03872 Factor: HNF-1beta; motif: GTTAATYATTAACY 0.0464003237242003 4145 69 29 0.420289855072464 0.00699638118214716
WP WP:WP698 Glucuronidation 0.0470226830517225 26 131 4 0.0305343511450382 0.153846153846154
WP WP:WP2881 Estrogen Receptor Pathway 0.0470226830517225 13 111 3 0.027027027027027 0.230769230769231
WP WP:WP4917 Proximal tubule transport 0.0470226830517225 58 103 5 0.0485436893203883 0.0862068965517241
WP WP:WP3942 PPAR signaling pathway 0.0470226830517225 67 111 6 0.0540540540540541 0.0895522388059701

pEpiTd24 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd24
Possible regulators of activation of pEpiTd24 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.