pEpiTp18 (G2 phase)

pEpiTp18 program activity among Epithelial cells
Epithelial cell compositional overview
pEpiTp18 top program genes
pEpiTp18 gene-set enrichment of top program genes (using g-profiler)
pEpiTp18 transcription factor target enrichment of top program genes

pEpiTp18 program activity among Epithelial cells

Activation of pEpiTp18 — pEpiTp18 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition — Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.

Gene program activation of pEpiTp18 by different cell subtypes — pEpiTp18 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp18 top program genes

Top genes of pEpiTp18 program — Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp18 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp18 — pEpiTp18 gene-set enrichment summary using g-profiler webtool.

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Source	termID	Name	Padj	Tsize	Qsize	Overlap	Precision	Recall
CORUM	CORUM:1743	(E.F.G) complex	0.000222633230295445	3	55	3	0.0545454545454545	1
CORUM	CORUM:320	55S ribosome, mitochondrial	0.000222633230295445	78	63	9	0.142857142857143	0.115384615384615
CORUM	CORUM:1068	12S U11 snRNP	0.00148468585928775	15	55	4	0.0727272727272727	0.266666666666667
CORUM	CORUM:315	28S ribosomal subunit, mitochondrial	0.00172647322507663	30	60	5	0.0833333333333333	0.166666666666667
CORUM	CORUM:2757	SMN complex, U7 snRNA specific	0.00172647322507663	7	55	3	0.0545454545454545	0.428571428571429
CORUM	CORUM:561	LSm1-7 complex	0.00209933422674516	7	74	3	0.0405405405405405	0.428571428571429
CORUM	CORUM:562	LSm2-8 complex	0.00209933422674516	7	74	3	0.0405405405405405	0.428571428571429
CORUM	CORUM:835	6S methyltransferase and RG-containing Sm proteins complex	0.00209933422674516	8	55	3	0.0545454545454545	0.375
CORUM	CORUM:1142	SMN complex	0.00209933422674516	9	55	3	0.0545454545454545	0.333333333333333
CORUM	CORUM:430	18S U11/U12 snRNP	0.00261045834578908	24	55	4	0.0727272727272727	0.166666666666667

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pEpiTp18 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp18 — Possible regulators of activation of pEpiTp18 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.