pEpi09 program activity among Epithelial cells

Activation of pEpi09
pEpi09 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi09 by different cell subtypes
pEpi09 gene program activation among cells of different subtypes (Epithelial cells).

pEpi09 top program genes

Top genes of pEpi09 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi09 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi09
pEpi09 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0010273 detoxification of copper ion 6.16241471449408e-26 14 35 11 0.314285714285714 0.785714285714286
GO:BP GO:1990169 stress response to copper ion 6.16241471449408e-26 14 35 11 0.314285714285714 0.785714285714286
GO:BP GO:0061687 detoxification of inorganic compound 3.68846765860977e-25 16 35 11 0.314285714285714 0.6875
GO:BP GO:0097501 stress response to metal ion 3.68846765860977e-25 16 35 11 0.314285714285714 0.6875
GO:BP GO:0071294 cellular response to zinc ion 9.05644393605654e-23 23 35 11 0.314285714285714 0.478260869565217
GO:BP GO:0071280 cellular response to copper ion 7.242173201438e-22 27 35 11 0.314285714285714 0.407407407407407
GO:BP GO:0071276 cellular response to cadmium ion 2.35752440998023e-20 37 8 8 1 0.216216216216216
GO:BP GO:0006882 cellular zinc ion homeostasis 2.35752440998023e-20 37 8 8 1 0.216216216216216
GO:BP GO:0055069 zinc ion homeostasis 3.33940375205797e-20 39 8 8 1 0.205128205128205
GO:BP GO:0046688 response to copper ion 5.76582880452267e-20 42 8 8 1 0.19047619047619
GO:BP GO:0010043 response to zinc ion 5.40715236395401e-19 55 8 8 1 0.145454545454545
GO:BP GO:0046686 response to cadmium ion 2.05472424886228e-18 65 8 8 1 0.123076923076923
GO:BP GO:0046916 cellular transition metal ion homeostasis 2.3872840081277e-16 116 8 8 1 0.0689655172413793
GO:BP GO:0098754 detoxification 7.27057093356493e-16 134 8 8 1 0.0597014925373134
GO:BP GO:0055076 transition metal ion homeostasis 8.64034074186582e-16 138 8 8 1 0.0579710144927536
GO:BP GO:0071248 cellular response to metal ion 1.20631930781837e-14 192 8 8 1 0.0416666666666667
GO:BP GO:0071241 cellular response to inorganic substance 3.43849044427027e-14 220 8 8 1 0.0363636363636364
GO:BP GO:0009636 response to toxic substance 7.28384604758913e-14 243 8 8 1 0.0329218106995885
GO:BP GO:0045926 negative regulation of growth 1.02036193401663e-13 255 8 8 1 0.0313725490196078
GO:BP GO:0010038 response to metal ion 2.01515915892047e-12 371 8 8 1 0.0215633423180593
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 2.02949807960353e-11 497 8 8 1 0.0160965794768612
GO:BP GO:0072507 divalent inorganic cation homeostasis 2.62084710410012e-11 516 8 8 1 0.0155038759689922
GO:BP GO:0010035 response to inorganic substance 5.99407606725678e-11 575 8 8 1 0.0139130434782609
GO:BP GO:0006875 cellular metal ion homeostasis 7.36175095220213e-11 593 8 8 1 0.0134907251264755
GO:BP GO:0055065 metal ion homeostasis 1.82018203712861e-10 667 8 8 1 0.0119940029985007
GO:BP GO:0030003 cellular cation homeostasis 1.88087133474109e-10 673 8 8 1 0.011887072808321
GO:BP GO:0040008 regulation of growth 1.9917686608895e-10 681 8 8 1 0.0117474302496329
GO:BP GO:0006873 cellular ion homeostasis 2.06100350216878e-10 687 8 8 1 0.0116448326055313
GO:BP GO:0055080 cation homeostasis 4.02876805257617e-10 750 8 8 1 0.0106666666666667
GO:BP GO:0098771 inorganic ion homeostasis 4.37796293628649e-10 761 8 8 1 0.0105124835742444
GO:BP GO:0050801 ion homeostasis 6.85773556077731e-10 808 8 8 1 0.0099009900990099
GO:BP GO:0055082 cellular chemical homeostasis 9.16354837186223e-10 841 8 8 1 0.00951248513674197
GO:BP GO:0040007 growth 2.72670478266962e-09 967 8 8 1 0.00827300930713547
GO:BP GO:0019725 cellular homeostasis 2.97025543169315e-09 981 8 8 1 0.00815494393476045
GO:BP GO:0048878 chemical homeostasis 1.76108589967863e-08 1229 8 8 1 0.0065093572009764
GO:BP GO:0042592 homeostatic process 7.87000913616302e-07 1981 8 8 1 0.00403836446239273
GO:BP GO:0070887 cellular response to chemical stimulus 5.41212523215118e-05 3393 8 8 1 0.00235779546124374
GO:BP GO:0065008 regulation of biological quality 0.000255143354414141 4131 8 8 1 0.00193657709997579
GO:BP GO:0006950 response to stress 0.000268370539583851 4170 8 8 1 0.00191846522781775
GO:BP GO:0042221 response to chemical 0.000782895880743584 4781 8 8 1 0.00167329010667224
GO:BP GO:0048519 negative regulation of biological process 0.00293279092832241 5757 20 15 0.75 0.00260552371026576
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0152334481493119 217 32 4 0.125 0.0184331797235023
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.0205985316101143 240 32 4 0.125 0.0166666666666667
GO:BP GO:0007389 pattern specification process 0.0226527570789856 442 32 5 0.15625 0.0113122171945701
GO:BP GO:0051716 cellular response to stimulus 0.0245767359842861 7781 8 8 1 0.00102814548258579
GO:BP GO:0003002 regionalization 0.0418732873394404 338 32 4 0.125 0.0118343195266272
GO:BP GO:0060485 mesenchyme development 0.0437442481519589 291 39 4 0.102564102564103 0.013745704467354
GO:CC GO:0005634 nucleus 0.0141494361074 7592 10 10 1 0.00131717597471022
GO:MF GO:0008270 zinc ion binding 2.57838087235851e-09 833 8 8 1 0.00960384153661465
GO:MF GO:0046914 transition metal ion binding 1.30179215648385e-08 1111 8 8 1 0.0072007200720072
GO:MF GO:0046872 metal ion binding 0.000367016385807845 4260 8 8 1 0.00187793427230047
GO:MF GO:0043169 cation binding 0.000367016385807845 4351 8 8 1 0.00183865777982073
GO:MF GO:0043167 ion binding 0.00134430283869692 6057 9 9 1 0.00148588410104012
GO:MF GO:0140110 transcription regulator activity 0.0499391407044841 1935 37 10 0.27027027027027 0.00516795865633075
KEGG KEGG:04978 Mineral absorption 1.49590059293688e-16 59 8 8 1 0.135593220338983
REAC REAC:R-HSA-5661231 Metallothioneins bind metals 4.4133244688753e-24 11 8 8 1 0.727272727272727
REAC REAC:R-HSA-5660526 Response to metal ions 4.01612526667652e-23 14 8 8 1 0.571428571428571
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 2.03391142302732e-09 560 8 8 1 0.0142857142857143
TF TF:M00650_1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 8.12229335732418e-12 24 5 5 1 0.208333333333333
TF TF:M01119_1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 1 1.83223863504007e-07 542 35 12 0.342857142857143 0.022140221402214
TF TF:M08890 Factor: MYB; motif: NNAACTGN 2.08850366285157e-07 1355 12 10 0.833333333333333 0.00738007380073801
TF TF:M00650 Factor: MTF-1; motif: TBTGCACHCGGCCC 2.40421114032228e-07 816 7 7 1 0.00857843137254902
TF TF:M10163 Factor: ZNF708; motif: GNNNAANAARNAGGYACAGC 3.15993756892196e-06 219 7 5 0.714285714285714 0.0228310502283105
TF TF:M07341_1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 4.08171264018246e-06 884 38 13 0.342105263157895 0.0147058823529412
TF TF:M09813_1 Factor: MYB; motif: NNCAACTGNN; match class: 1 5.19061227836958e-05 979 10 7 0.7 0.00715015321756895
TF TF:M07341 Factor: TORC2; motif: TGGGCTKKD 0.000138809324712613 4887 39 25 0.641025641025641 0.00511561285041948
TF TF:M04619_1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 0.000160945642847783 50 6 3 0.5 0.06
TF TF:M02088 Factor: E2A; motif: NRMCASCTGCNNN 0.0005425160982807 2871 41 19 0.463414634146341 0.00661790316962731
TF TF:M07299 Factor: c-Myb; motif: NNNNCMGTTNNN 0.000643283721475722 3767 8 8 1 0.00212370586673746
TF TF:M08890_1 Factor: MYB; motif: NNAACTGN; match class: 1 0.000643283721475722 63 8 3 0.375 0.0476190476190476
TF TF:M04903_1 Factor: HNF-4alpha; motif: AGTCCAAR; match class: 1 0.000643283721475722 1534 10 7 0.7 0.0045632333767927
TF TF:M09990_1 Factor: c-Myb; motif: NNWGRCAGTTRN; match class: 1 0.000843686137556694 3933 8 8 1 0.00203407068395627
TF TF:M10085 Factor: RBPJK; motif: NSNSTGGGAAN 0.0012926323565503 3436 13 10 0.769230769230769 0.00291036088474971
TF TF:M04619 Factor: MTF-1; motif: CCGNGTGCAV 0.0012926323565503 1167 6 5 0.833333333333333 0.00428449014567267
TF TF:M08952 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN 0.00139158674564103 7763 40 30 0.75 0.00386448537936365
TF TF:M04218 Factor: MAFK; motif: NTGCTGANTCAGCRN 0.00239460427742058 261 4 3 0.75 0.0114942528735632
TF TF:M11344_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.00245612204011021 268 4 3 0.75 0.0111940298507463
TF TF:M11344 Factor: MafF; motif: NTGCTGASTCAGCAN 0.00260442950948409 278 4 3 0.75 0.0107913669064748
TF TF:M09746 Factor: HNRPUL1; motif: NCNCAGN 0.00287632516049252 13720 39 38 0.974358974358974 0.00276967930029155
TF TF:M11346_1 Factor: MafG; motif: NTGCTGASTCAGCAN; match class: 1 0.00303514999432948 302 4 3 0.75 0.00993377483443709
TF TF:M11346 Factor: MafG; motif: NTGCTGASTCAGCAN 0.00351849469908004 322 4 3 0.75 0.0093167701863354
TF TF:M06617 Factor: ZNF480; motif: NGTGACCRGGGM 0.00383148695873628 48 22 3 0.136363636363636 0.0625
TF TF:M04926 Factor: REST; motif: AAGGTGCT 0.00383148695873628 6325 15 13 0.866666666666667 0.00205533596837945
TF TF:M00466 Factor: HIF1; motif: NGTACGTGCNGB 0.0040205795921885 2997 32 15 0.46875 0.005005005005005
TF TF:M07387_1 Factor: LRF; motif: NGKGGGTSNCN; match class: 1 0.00471631035589105 1040 32 9 0.28125 0.00865384615384615
TF TF:M00411 Factor: HNF4alpha1; motif: NRGGNCAAAGGTCAN 0.00471631035589105 1811 34 12 0.352941176470588 0.00662617338487024
TF TF:M11779 Factor: RXR-gamma; motif: RRGGTCAYGACCYY 0.00471631035589105 54 22 3 0.136363636363636 0.0555555555555556
TF TF:M04903 Factor: HNF-4alpha; motif: AGTCCAAR 0.00490988751109616 6987 10 10 1 0.001431229426077
TF TF:M00631 Factor: FXR:RXR-alpha; motif: CAAGGTSAWTAACC 0.00511422685058081 3541 6 6 1 0.00169443659983056
TF TF:M01201_1 Factor: AR; motif: GGNACRNNRTGTWCT; match class: 1 0.00520194060392854 2129 8 6 0.75 0.00281822451855331
TF TF:M01859 Factor: AP-2; motif: NNGCCTK 0.00520194060392854 7799 11 11 1 0.00141043723554302
TF TF:M10012 Factor: Rev-ErbAalpha; motif: NRNNMASTGGGTCANNNNN 0.00520194060392854 1105 13 6 0.461538461538462 0.00542986425339366
TF TF:M09813 Factor: MYB; motif: NNCAACTGNN 0.00527912024242508 5545 8 8 1 0.00144274120829576
TF TF:M11803_1 Factor: NR1B2; motif: RAGGTCATGACCTN; match class: 1 0.00551020831873076 915 22 7 0.318181818181818 0.00765027322404372
TF TF:M12280_1 Factor: MTF-1; motif: NTTTTGCACACGGCNNN; match class: 1 0.00569821121452298 1485 7 5 0.714285714285714 0.00336700336700337
TF TF:M04636_1 Factor: TFII-I; motif: NAGGAAGTGN; match class: 1 0.00588616306641254 5733 8 8 1 0.00139542996685854
TF TF:M07299_1 Factor: c-Myb; motif: NNNNCMGTTNNN; match class: 1 0.00588616306641254 450 10 4 0.4 0.00888888888888889
TF TF:M08954 Factor: FXR:RXR-ALPHA; motif: NAGKTCATTGACCYN 0.00588616306641254 6443 41 26 0.634146341463415 0.00403538724196803
TF TF:M11365_1 Factor: MafA; motif: NYGCTGASTCAGCRN; match class: 1 0.00588616306641254 467 4 3 0.75 0.00642398286937901
TF TF:M00481_1 Factor: AR; motif: GGTACANNRTGTTCT; match class: 1 0.00606449773486358 2295 8 6 0.75 0.00261437908496732
TF TF:M00468_1 Factor: AP-2rep; motif: CAGTGGG; match class: 1 0.00606449773486358 1686 18 8 0.444444444444444 0.00474495848161329
TF TF:M12279 Factor: MTF-1; motif: NTTTTGCACACGGCNYN 0.00644976314394283 6713 9 9 1 0.00134068225830478
TF TF:M11365 Factor: MafA; motif: NYGCTGASTCAGCRN 0.00680143952722918 506 4 3 0.75 0.00592885375494071
TF TF:M11800_1 Factor: NR1B2; motif: RAGGTCRTGACCTY; match class: 1 0.00683711037673233 987 22 7 0.318181818181818 0.00709219858156028
TF TF:M11340_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.00727641062878275 525 4 3 0.75 0.00571428571428571
TF TF:M01119 Factor: Kaiso; motif: NTCCTGCNAN 0.00780192666418826 4264 29 16 0.551724137931034 0.00375234521575985
TF TF:M00156 Factor: RORalpha1; motif: NWAWNNAGGTCAN 0.00780192666418826 255 35 5 0.142857142857143 0.0196078431372549
TF TF:M07611_1 Factor: p54NRB; motif: GRNNNMGGATGRMNNCGGA; match class: 1 0.00813501522578761 1645 41 12 0.292682926829268 0.00729483282674772
TF TF:M11368_1 Factor: MafA; motif: NTGCTGASTCAGCAN; match class: 1 0.00840650131915372 566 4 3 0.75 0.00530035335689046
TF TF:M11368 Factor: MafA; motif: NTGCTGASTCAGCAN 0.00842299825561113 570 4 3 0.75 0.00526315789473684
TF TF:M11899_1 Factor: Oct-2; motif: NTGCATATGCAN; match class: 1 0.00849773841576567 4493 23 14 0.608695652173913 0.00311595815713332
TF TF:M11340 Factor: MafF; motif: NTGCTGASTCAGCAN 0.00854889482338572 580 4 3 0.75 0.00517241379310345
TF TF:M11274 Factor: XBP-1; motif: NGMCACRTCAYC 0.0085730017027678 1759 7 5 0.714285714285714 0.00284252416145537
TF TF:M08954_1 Factor: FXR:RXR-ALPHA; motif: NAGKTCATTGACCYN; match class: 1 0.00916432032147964 2260 41 14 0.341463414634146 0.00619469026548673
TF TF:M00088 Factor: Ik-3; motif: TNYTGGGAATACC 0.00916432032147964 5762 10 9 0.9 0.0015619576535925
TF TF:M00004_1 Factor: c-Myb; motif: NCNRNNGRCNGTTGGKGG; match class: 1 0.00916432032147964 1883 27 10 0.37037037037037 0.00531067445565587
TF TF:M08208 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC 0.00932148003694817 12560 41 37 0.902439024390244 0.00294585987261147
TF TF:M04715 Factor: Oct-2; motif: ATTTGCA 0.00932148003694817 6381 8 8 1 0.00125372198714935
TF TF:M04818 Factor: IRF-4; motif: RGGAASWGR 0.0096202366267397 9372 16 15 0.9375 0.00160051216389245
TF TF:M10432 Factor: MAZ; motif: GGGMGGGGS 0.00979223194525074 9259 39 30 0.769230769230769 0.00324009072254023
TF TF:M08284 Factor: Fli-1:FIGLA; motif: NCCGGAARCASSTGN 0.0100124914045713 7942 40 28 0.7 0.00352556031226391
TF TF:M12324 Factor: ZBTB12; motif: TGGCCTGNCGTCGY 0.0105404285763236 93 22 3 0.136363636363636 0.032258064516129
TF TF:M11066 Factor: HES-7; motif: GNCACGYGNN 0.0112915901092773 11507 34 30 0.882352941176471 0.00260710871643348
TF TF:M03895_1 Factor: CTCF; motif: WGCGCCMYCTAGYGGYN; match class: 1 0.0114392667199151 3511 39 17 0.435897435897436 0.00484192537738536
TF TF:M11058 Factor: Hey1; motif: NGCRCGYGYN 0.0114523547140753 13162 34 32 0.941176470588235 0.00243124145266677
TF TF:M00147 Factor: HSF2; motif: NGAANNWTCK 0.0119871363650941 5830 12 10 0.833333333333333 0.00171526586620926
TF TF:M08289 Factor: Fli-1:Max; motif: NCCGGAAACACGTGN 0.0121485723377092 9971 39 31 0.794871794871795 0.00310901614682579
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0121485723377092 13929 39 37 0.948717948717949 0.00265632852322493
TF TF:M00192 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN 0.0121485723377092 7611 9 9 1 0.00118249901458415
TF TF:M09725 Factor: DREF; motif: CTYYCWCTTCCY 0.0121766704001686 7519 12 11 0.916666666666667 0.0014629605000665
TF TF:M12280 Factor: MTF-1; motif: NTTTTGCACACGGCNNN 0.0139416973270556 6897 8 8 1 0.00115992460490068
TF TF:M04453_1 Factor: AR; motif: RGGWACAYNGTGTWCYN; match class: 1 0.0149258894598337 3794 9 7 0.777777777777778 0.0018450184501845
TF TF:M11052 Factor: Hey2; motif: NNCACGYGNN 0.0150747640750924 12502 34 31 0.911764705882353 0.00247960326347784
TF TF:M11739 Factor: COUP-TF1; motif: RRGGTCRNTGACCTN 0.0150747640750924 2698 6 5 0.833333333333333 0.00185322461082283
TF TF:M00444_1 Factor: VDR; motif: GGGKNARNRRGGWSA; match class: 1 0.0150747640750924 4534 27 15 0.555555555555556 0.00330833700926334
TF TF:M01169 Factor: Ikaros; motif: KYTGGGAGGN 0.0159187977347439 503 36 6 0.166666666666667 0.0119284294234592
TF TF:M12057 Factor: ZBP99; motif: GCCCMTCCCCCR 0.0161206577422155 5225 22 14 0.636363636363636 0.00267942583732057
TF TF:M10110 Factor: TCF17; motif: NTTTANNYCATTTACATTTANTGT 0.0165533739803328 616 5 3 0.6 0.00487012987012987
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.0166562193341329 11063 34 29 0.852941176470588 0.0026213504474374
TF TF:M08674_1 Factor: AP-4:Max; motif: NCAGCTGNNNNNNNCACGTGN; match class: 1 0.0173450990435058 5667 9 8 0.888888888888889 0.00141168166578437
TF TF:M09912_1 Factor: c-Ets-2; motif: NNNRGGAARNRRR; match class: 1 0.0175542549500635 2450 24 10 0.416666666666667 0.00408163265306122
TF TF:M00146 Factor: HSF1; motif: AGAANRTTCN 0.0190329382476433 2678 12 7 0.583333333333333 0.00261389096340553
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.0190329382476433 9162 34 26 0.764705882352941 0.00283780833879066
TF TF:M09746_1 Factor: HNRPUL1; motif: NCNCAGN; match class: 1 0.0190329382476433 7619 39 26 0.666666666666667 0.0034125213282583
TF TF:M06099 Factor: ZNF14; motif: GTTGTAAAGA 0.0190934006907801 242 12 3 0.25 0.012396694214876
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.0190934006907801 13173 37 34 0.918918918918919 0.00258103696955895
TF TF:M00279_1 Factor: MIF-1; motif: NNGTTGCWWGGYAACNGS; match class: 1 0.0201029219344736 5341 6 6 1 0.00112338513387006
TF TF:M11807 Factor: RAR-gamma; motif: RAGGTCATGACCTY 0.0209474290566094 2046 24 9 0.375 0.00439882697947214
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0209474290566094 13611 28 27 0.964285714285714 0.00198368966277276
TF TF:M03831_1 Factor: MRF4; motif: CASCTGC; match class: 1 0.0209627620493207 2796 38 14 0.368421052631579 0.0050071530758226
TF TF:M02018_1 Factor: HTF4; motif: CASCTGB; match class: 1 0.0209627620493207 2796 38 14 0.368421052631579 0.0050071530758226
TF TF:M03846 Factor: SMAD5; motif: GSGGCAGM 0.0209627620493207 8552 36 26 0.722222222222222 0.00304022450888681
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0213514116532812 9362 37 28 0.756756756756757 0.00299081392864772
TF TF:M00194 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN 0.0219452966744567 2412 7 5 0.714285714285714 0.00207296849087894
TF TF:M11777 Factor: RXR-gamma; motif: NRGGTCAYGACCYN 0.0220187420182319 138 22 3 0.136363636363636 0.0217391304347826
TF TF:M10013_1 Factor: LXR-alpha; motif: NNRRGGTYACTNNAGGNCA; match class: 1 0.0222417130210811 342 38 5 0.131578947368421 0.0146198830409357
TF TF:M09737 Factor: ZNF644; motif: TCCWGCCTCTSN 0.0225744822286895 7275 18 14 0.777777777777778 0.00192439862542955
TF TF:M11783 Factor: RXR-beta; motif: RRGGTCATGACCYY 0.0242129295106288 144 22 3 0.136363636363636 0.0208333333333333
TF TF:M04721_1 Factor: STAT1; motif: NTTCCNGGA; match class: 1 0.025799932701136 2635 41 14 0.341463414634146 0.00531309297912713
TF TF:M07084 Factor: E2F-4; motif: NGGCGGGAARN 0.0262411479773238 10834 28 24 0.857142857142857 0.00221524829241277
TF TF:M11741 Factor: COUP-TF1; motif: RRGGTCRNTGACCYY 0.0267792687760663 3249 17 9 0.529411764705882 0.00277008310249307
TF TF:M02016 Factor: HNF-4alpha; motif: GNNCAAAGKYCANNN 0.0270746087145675 2384 22 9 0.409090909090909 0.0037751677852349
TF TF:M04412_1 Factor: NKX2-8; motif: NCACTTSAN; match class: 1 0.02746900852266 318 25 4 0.16 0.0125786163522013
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.02746900852266 3919 39 17 0.435897435897436 0.00433784128604236
TF TF:M07041 Factor: HDAC1; motif: KGCARGGTC 0.02746900852266 12526 36 32 0.888888888888889 0.0025546862525946
TF TF:M01073_1 Factor: HIC1; motif: NNNGGKTGCCCSNNNNNN; match class: 1 0.0276838844974227 762 39 7 0.179487179487179 0.00918635170603675
TF TF:M11765_1 Factor: TR2; motif: NRGGTCRYGACCYN; match class: 1 0.0280841710681973 1431 22 7 0.318181818181818 0.00489168413696716
TF TF:M11818_1 Factor: T3R-beta; motif: NTGACCTYRNYRAGGTCAN; match class: 1 0.0280841710681973 11261 33 28 0.848484848484849 0.00248645768581831
TF TF:M01249_1 Factor: HIF2alpha; motif: NNACGTGCNN; match class: 1 0.0281163768942274 107 32 3 0.09375 0.0280373831775701
TF TF:M11018_1 Factor: IRX-1; motif: NACRYNNNNNNNNRYGNN; match class: 1 0.0281163768942274 15920 34 34 1 0.0021356783919598
TF TF:M08402 Factor: POU2F1:PEA3; motif: ACCGGATATGCAN 0.028499851801869 8519 12 11 0.916666666666667 0.00129123136518371
TF TF:M09773_1 Factor: HIF1A; motif: NNACGTGCNN; match class: 1 0.028499851801869 683 32 6 0.1875 0.00878477306002928
TF TF:M01104_1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 0.0293761754605612 5626 34 19 0.558823529411765 0.0033771773906861
TF TF:M04110 Factor: RUNX3; motif: NRACCGCANWAACCRCAN 0.0293761754605612 9266 38 28 0.736842105263158 0.00302180012950572
TF TF:M02070 Factor: TEL1; motif: CNCGGAANNN 0.0293761754605612 10837 24 21 0.875 0.00193780566577466
TF TF:M07406 Factor: SREBP-2; motif: RTGGGGTGAY 0.0300432240316995 5983 6 6 1 0.00100284138392111
TF TF:M08445_1 Factor: AP-4:Fli-1; motif: RSCGGAWRCAGSTGN; match class: 1 0.0301366474300198 3143 40 15 0.375 0.00477251034043907
TF TF:M01100_1 Factor: LRF; motif: GGGGKYNNB; match class: 1 0.0311620104827713 2762 32 12 0.375 0.00434467776973208
TF TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 0.0320851437670563 4556 7 6 0.857142857142857 0.00131694468832309
TF TF:M09664 Factor: STAT3; motif: NTTCCYGGAAN 0.0328646862211258 5587 8 7 0.875 0.00125290853767675
TF TF:M11899 Factor: Oct-2; motif: NTGCATATGCAN 0.0329994220833745 5597 8 7 0.875 0.00125067000178667
TF TF:M10051 Factor: RORgamma; motif: NNAASTRGGTCA 0.0338778408588386 1550 11 5 0.454545454545455 0.0032258064516129
TF TF:M05361 Factor: Sp6; motif: WGGGCGG 0.0348009945929719 8578 25 19 0.76 0.0022149685241315
TF TF:M05332 Factor: Sp2; motif: WGGGCGG 0.0348009945929719 8578 25 19 0.76 0.0022149685241315
TF TF:M00774 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN 0.0348009945929719 1818 14 6 0.428571428571429 0.0033003300330033
TF TF:M04490_1 Factor: RXRA; motif: RRGGTCATGACCYY; match class: 1 0.0348009945929719 3535 23 11 0.478260869565217 0.00311173974540311
TF TF:M05444 Factor: CPBP; motif: NGGGCGG 0.0348009945929719 8578 25 19 0.76 0.0022149685241315
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.0348009945929719 7557 39 25 0.641025641025641 0.00330819108111685
TF TF:M04636 Factor: TFII-I; motif: NAGGAAGTGN 0.0362443963515342 12845 16 16 1 0.00124562086414947
TF TF:M04054_1 Factor: NF-kappaB; motif: AGGGGAWTCCCCT; match class: 1 0.0362443963515342 1295 8 4 0.5 0.00308880308880309
TF TF:M11817_1 Factor: T3R-beta; motif: NRRGGTCRTGACCYYN; match class: 1 0.0397240384150015 1566 22 7 0.318181818181818 0.00446998722860792
TF TF:M08957 Factor: NURR1:RXR-ALPHA; motif: NRGGTCRTTGACCYN 0.0397661878486879 8851 23 18 0.782608695652174 0.00203366851203254
TF TF:M04721 Factor: STAT1; motif: NTTCCNGGA 0.0422033384800517 7847 13 11 0.846153846153846 0.00140180960876768
TF TF:M00450_1 Factor: Zic3; motif: NGGGKGGTC; match class: 1 0.0431206505589612 7927 25 18 0.72 0.00227072032294689
TF TF:M12259 Factor: slug; motif: NRCAGGTGCR 0.0438319267443698 1780 15 6 0.4 0.00337078651685393
TF TF:M09944_1 Factor: HIF-1alpha; motif: GNACGTGM; match class: 1 0.044018890864315 1384 32 8 0.25 0.00578034682080925
TF TF:M01240 Factor: BEN; motif: CAGCGRNV 0.044375430547091 16498 37 37 1 0.00224269608437386
TF TF:M09777_1 Factor: NR1H4; motif: NNAATGACCNN; match class: 1 0.0447170737206979 522 9 3 0.333333333333333 0.00574712643678161
TF TF:M09947 Factor: HNF-4alpha; motif: NRGKNCAAAGTCCA 0.0447170737206979 2111 22 8 0.363636363636364 0.00378967314069162
TF TF:M09827 Factor: CREB1; motif: NGRTGAYGWNNN 0.045161189019168 2676 18 8 0.444444444444444 0.00298953662182362
TF TF:M00481 Factor: AR; motif: GGTACANNRTGTTCT 0.0458907042840599 4981 9 7 0.777777777777778 0.00140534029311383
TF TF:M01168 Factor: SREBP; motif: NNNNYCACNCCANNN 0.046814724275968 6651 6 6 1 0.0009021199819576
TF TF:M01837 Factor: FKLF; motif: BGGGNGGVMD 0.0478470170903774 5442 24 14 0.583333333333333 0.00257258360896729
TF TF:M11831_1 Factor: LRH-1; motif: TCAAGGTCRTGACCTTGA; match class: 1 0.0484687639355878 1082 24 6 0.25 0.0055452865064695
WP WP:WP3529 Zinc homeostasis 6.73113823242473e-18 37 8 8 1 0.216216216216216
WP WP:WP3286 Copper homeostasis 1.16295170440211e-13 54 8 7 0.875 0.12962962962963

pEpi09 transcription factor target enrichment of top program genes

TF enrichment of pEpi09
Possible regulators of activation of pEpi09 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.