pP09 program activity among Plasma cells

Activation of pP09
pP09 gene program activation in Plasma cells.
Gene program activation of pP09 by different cell subtypes
pP09 gene program activation among cells of different subtypes (Plasma cells).

pP09 top program genes

Top genes of pP09 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pP09 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pP09
pP09 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:7385 DTX3L-PARP9-STAT1 complex 0.000332874421544372 3 81 3 0.037037037037037 1
GO:BP GO:0051607 defense response to virus 3.17751051591476e-38 267 106 37 0.349056603773585 0.138576779026217
GO:BP GO:0140546 defense response to symbiont 3.17751051591476e-38 267 106 37 0.349056603773585 0.138576779026217
GO:BP GO:0009615 response to virus 3.50817956283475e-37 364 117 41 0.35042735042735 0.112637362637363
GO:BP GO:0060337 type I interferon signaling pathway 1.4596069263889e-34 95 76 24 0.315789473684211 0.252631578947368
GO:BP GO:0071357 cellular response to type I interferon 1.55260351563787e-34 96 76 24 0.315789473684211 0.25
GO:BP GO:0034340 response to type I interferon 5.11554942029542e-34 101 76 24 0.315789473684211 0.237623762376238
GO:BP GO:0045087 innate immune response 2.99197994175395e-28 998 113 48 0.424778761061947 0.0480961923847695
GO:BP GO:0098542 defense response to other organism 9.73047826858787e-28 1218 117 52 0.444444444444444 0.0426929392446634
GO:BP GO:0048525 negative regulation of viral process 2.18522918114081e-25 94 108 21 0.194444444444444 0.223404255319149
GO:BP GO:0051707 response to other organism 2.19546595445088e-25 1592 108 53 0.490740740740741 0.0332914572864322
GO:BP GO:0043207 response to external biotic stimulus 2.19546595445088e-25 1594 108 53 0.490740740740741 0.0332496863237139
GO:BP GO:0009607 response to biotic stimulus 5.28995379806901e-25 1626 108 53 0.490740740740741 0.0325953259532595
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 1.10899571936932e-24 2255 92 55 0.597826086956522 0.024390243902439
GO:BP GO:0050792 regulation of viral process 1.49292236011353e-24 192 108 25 0.231481481481481 0.130208333333333
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 5.17888131774352e-24 203 108 25 0.231481481481481 0.123152709359606
GO:BP GO:1903900 regulation of viral life cycle 5.17888131774352e-24 153 108 23 0.212962962962963 0.150326797385621
GO:BP GO:0034097 response to cytokine 5.17888131774352e-24 1226 92 43 0.467391304347826 0.0350734094616639
GO:BP GO:0045071 negative regulation of viral genome replication 5.20859488805183e-24 54 100 17 0.17 0.314814814814815
GO:BP GO:0006955 immune response 2.29729216865362e-22 2311 108 58 0.537037037037037 0.0250973604500216
GO:BP GO:0006952 defense response 2.29729216865362e-22 1818 118 55 0.466101694915254 0.0302530253025303
GO:BP GO:0019221 cytokine-mediated signaling pathway 2.53628214047344e-22 810 62 30 0.483870967741935 0.037037037037037
GO:BP GO:0045069 regulation of viral genome replication 3.48307273799004e-22 84 100 18 0.18 0.214285714285714
GO:BP GO:0071345 cellular response to cytokine stimulus 3.86557900689527e-20 1132 92 38 0.41304347826087 0.0335689045936396
GO:BP GO:0019079 viral genome replication 4.31865403057914e-20 131 100 19 0.19 0.145038167938931
GO:BP GO:0016032 viral process 4.31865403057914e-20 942 90 35 0.388888888888889 0.0371549893842887
GO:BP GO:0044403 biological process involved in symbiotic interaction 3.01006696517668e-19 1001 90 35 0.388888888888889 0.034965034965035
GO:BP GO:0002252 immune effector process 3.86507651428911e-19 1309 106 42 0.39622641509434 0.0320855614973262
GO:BP GO:0019058 viral life cycle 3.18893258552915e-18 353 108 25 0.231481481481481 0.0708215297450425
GO:BP GO:0034341 response to interferon-gamma 1.2861389432362e-17 196 106 20 0.188679245283019 0.102040816326531
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 2.05368191715448e-16 88 106 15 0.141509433962264 0.170454545454545
GO:BP GO:0002376 immune system process 5.83234321469472e-16 3278 93 54 0.580645161290323 0.0164734594264796
GO:BP GO:0009605 response to external stimulus 5.50437273856934e-15 2944 108 55 0.509259259259259 0.0186820652173913
GO:BP GO:0035455 response to interferon-alpha 7.3025585200117e-15 23 71 9 0.126760563380282 0.391304347826087
GO:BP GO:0071346 cellular response to interferon-gamma 1.64466139507575e-14 175 106 17 0.160377358490566 0.0971428571428571
GO:BP GO:0006950 response to stress 2.93589582814719e-13 4170 119 67 0.563025210084034 0.0160671462829736
GO:BP GO:0010033 response to organic substance 1.71637499510231e-12 3412 92 50 0.543478260869565 0.0146541617819461
GO:BP GO:0071310 cellular response to organic substance 2.29338511966506e-12 2776 92 45 0.489130434782609 0.0162103746397695
GO:BP GO:0035456 response to interferon-beta 9.95446249534578e-11 30 91 8 0.0879120879120879 0.266666666666667
GO:BP GO:0002831 regulation of response to biotic stimulus 1.18261672476705e-09 415 103 18 0.174757281553398 0.0433734939759036
GO:BP GO:0007166 cell surface receptor signaling pathway 2.71182019850533e-09 3210 62 34 0.548387096774194 0.0105919003115265
GO:BP GO:0070887 cellular response to chemical stimulus 2.84812986989504e-09 3393 92 45 0.489130434782609 0.013262599469496
GO:BP GO:0045088 regulation of innate immune response 2.85437419783594e-08 309 92 14 0.152173913043478 0.0453074433656958
GO:BP GO:0032479 regulation of type I interferon production 2.94191505667229e-08 130 113 11 0.0973451327433628 0.0846153846153846
GO:BP GO:0032606 type I interferon production 3.12236732245181e-08 131 113 11 0.0973451327433628 0.083969465648855
GO:BP GO:0042221 response to chemical 8.79001549639945e-08 4781 62 39 0.629032258064516 0.00815728927002719
GO:BP GO:0031347 regulation of defense response 6.78224932243573e-07 704 92 18 0.195652173913043 0.0255681818181818
GO:BP GO:0050776 regulation of immune response 1.21402701228271e-06 996 93 21 0.225806451612903 0.0210843373493976
GO:BP GO:0032020 ISG15-protein conjugation 1.5446426353604e-06 6 22 3 0.136363636363636 0.5
GO:BP GO:0060700 regulation of ribonuclease activity 1.73008332602346e-06 9 76 4 0.0526315789473684 0.444444444444444
GO:BP GO:0002682 regulation of immune system process 2.1422857201813e-06 1617 52 19 0.365384615384615 0.0117501546072975
GO:BP GO:0000209 protein polyubiquitination 3.46208091197193e-06 342 86 12 0.13953488372093 0.0350877192982456
GO:BP GO:0032480 negative regulation of type I interferon production 5.31712120664089e-06 46 92 6 0.0652173913043478 0.130434782608696
GO:BP GO:0098586 cellular response to virus 7.66833594637333e-06 72 103 7 0.0679611650485437 0.0972222222222222
GO:BP GO:0039530 MDA-5 signaling pathway 8.76150579835875e-06 10 103 4 0.0388349514563107 0.4
GO:BP GO:0046596 regulation of viral entry into host cell 8.76150579835875e-06 43 108 6 0.0555555555555556 0.13953488372093
GO:BP GO:0140289 protein mono-ADP-ribosylation 9.71558457648187e-06 12 86 4 0.0465116279069767 0.333333333333333
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 1.01376891886506e-05 185 113 10 0.0884955752212389 0.0540540540540541
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 1.1306375095962e-05 291 113 12 0.106194690265487 0.0412371134020619
GO:BP GO:0048519 negative regulation of biological process 1.90272660667844e-05 5757 28 22 0.785714285714286 0.00382143477505645
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 1.93515300214286e-05 251 113 11 0.0973451327433628 0.0438247011952191
GO:BP GO:0052372 modulation by symbiont of entry into host 1.96357200431032e-05 50 108 6 0.0555555555555556 0.12
GO:BP GO:0032481 positive regulation of type I interferon production 2.5628929383641e-05 80 113 7 0.0619469026548673 0.0875
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 2.60686260307735e-05 184 50 7 0.14 0.0380434782608696
GO:BP GO:0060759 regulation of response to cytokine stimulus 2.63839345039517e-05 197 92 9 0.0978260869565217 0.0456852791878173
GO:BP GO:0045824 negative regulation of innate immune response 3.80351114296678e-05 66 92 6 0.0652173913043478 0.0909090909090909
GO:BP GO:0050688 regulation of defense response to virus 4.45154282932409e-05 71 88 6 0.0681818181818182 0.0845070422535211
GO:BP GO:0002833 positive regulation of response to biotic stimulus 5.71948848954069e-05 250 103 10 0.0970873786407767 0.04
GO:BP GO:0007165 signal transduction 5.79072462817398e-05 6309 113 64 0.566371681415929 0.0101442383896022
GO:BP GO:0032069 regulation of nuclease activity 6.84372589480521e-05 22 76 4 0.0526315789473684 0.181818181818182
GO:BP GO:0001817 regulation of cytokine production 7.07775007500753e-05 806 28 9 0.321428571428571 0.011166253101737
GO:BP GO:0023052 signaling 7.07775007500753e-05 6810 55 38 0.690909090909091 0.00558002936857562
GO:BP GO:0080134 regulation of response to stress 7.68130187970473e-05 1443 92 22 0.239130434782609 0.0152460152460152
GO:BP GO:0045089 positive regulation of innate immune response 8.6347554064909e-05 216 52 7 0.134615384615385 0.0324074074074074
GO:BP GO:1903901 negative regulation of viral life cycle 9.79320710465541e-05 26 71 4 0.0563380281690141 0.153846153846154
GO:BP GO:0001816 cytokine production 9.79320710465541e-05 844 28 9 0.321428571428571 0.0106635071090047
GO:BP GO:0032101 regulation of response to external stimulus 0.000121709985082123 1051 118 21 0.177966101694915 0.0199809705042816
GO:BP GO:0032727 positive regulation of interferon-alpha production 0.0001260066794389 24 83 4 0.0481927710843374 0.166666666666667
GO:BP GO:0050778 positive regulation of immune response 0.000193946341556939 753 93 15 0.161290322580645 0.0199203187250996
GO:BP GO:0051716 cellular response to stimulus 0.000199952709590554 7781 113 72 0.63716814159292 0.00925330934327207
GO:BP GO:0051701 biological process involved in interaction with host 0.000208819528797846 221 108 9 0.0833333333333333 0.0407239819004525
GO:BP GO:0045646 regulation of erythrocyte differentiation 0.000215024667455288 47 15 3 0.2 0.0638297872340425
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.000219272275442627 213 113 9 0.079646017699115 0.0422535211267606
GO:BP GO:0007154 cell communication 0.000234393422773622 6829 55 37 0.672727272727273 0.00541806999560697
GO:BP GO:0060330 regulation of response to interferon-gamma 0.000240381211210372 26 92 4 0.0434782608695652 0.153846153846154
GO:BP GO:0060334 regulation of interferon-gamma-mediated signaling pathway 0.000240381211210372 26 92 4 0.0434782608695652 0.153846153846154
GO:BP GO:0032607 interferon-alpha production 0.000279476263421905 30 83 4 0.0481927710843374 0.133333333333333
GO:BP GO:0032647 regulation of interferon-alpha production 0.000279476263421905 30 83 4 0.0481927710843374 0.133333333333333
GO:BP GO:0060760 positive regulation of response to cytokine stimulus 0.000279476263421905 57 92 5 0.0543478260869565 0.087719298245614
GO:BP GO:0048584 positive regulation of response to stimulus 0.000282898062589905 2344 118 33 0.279661016949153 0.0140784982935154
GO:BP GO:0002832 negative regulation of response to biotic stimulus 0.000313867735697372 100 92 6 0.0652173913043478 0.06
GO:BP GO:0050896 response to stimulus 0.000329445468858865 9407 108 78 0.722222222222222 0.00829169767194642
GO:BP GO:0002684 positive regulation of immune system process 0.000438540230289543 1065 118 20 0.169491525423729 0.0187793427230047
GO:BP GO:0034154 toll-like receptor 7 signaling pathway 0.000490822270506382 12 82 3 0.0365853658536585 0.25
GO:BP GO:0046718 viral entry into host cell 0.000548860397645332 141 108 7 0.0648148148148148 0.049645390070922
GO:BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 0.000554431392212478 68 90 5 0.0555555555555556 0.0735294117647059
GO:BP GO:0034162 toll-like receptor 9 signaling pathway 0.000561404192932098 27 113 4 0.0353982300884956 0.148148148148148
GO:BP GO:0006471 protein ADP-ribosylation 0.000611918313690138 36 86 4 0.0465116279069767 0.111111111111111
GO:BP GO:0032728 positive regulation of interferon-beta production 0.000663218450026987 36 88 4 0.0454545454545455 0.111111111111111
GO:BP GO:0051336 regulation of hydrolase activity 0.000690440695757005 1321 55 14 0.254545454545455 0.0105980317940954
GO:BP GO:0060338 regulation of type I interferon-mediated signaling pathway 0.000691040644307626 35 92 4 0.0434782608695652 0.114285714285714
GO:BP GO:0032103 positive regulation of response to external stimulus 0.000707804297037144 513 118 13 0.110169491525424 0.0253411306042885
GO:BP GO:0006915 apoptotic process 0.000721663561041647 1990 53 17 0.320754716981132 0.0085427135678392
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.000818502197045672 3241 23 13 0.565217391304348 0.00401110768281395
GO:BP GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.000818502197045672 33 103 4 0.0388349514563107 0.121212121212121
GO:BP GO:0044409 entry into host 0.000866271959117716 154 108 7 0.0648148148148148 0.0454545454545455
GO:BP GO:0052548 regulation of endopeptidase activity 0.00102075406653094 437 28 6 0.214285714285714 0.0137299771167048
GO:BP GO:0038061 NIK/NF-kappaB signaling 0.00113174406075643 194 90 7 0.0777777777777778 0.0360824742268041
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.00114581303558075 263 15 4 0.266666666666667 0.0152091254752852
GO:BP GO:0048583 regulation of response to stimulus 0.00121131050855131 4278 108 44 0.407407407407407 0.0102851799906498
GO:BP GO:0030097 hemopoiesis 0.0012297798998389 928 28 8 0.285714285714286 0.00862068965517241
GO:BP GO:0002697 regulation of immune effector process 0.00132627170636299 461 103 11 0.106796116504854 0.0238611713665944
GO:BP GO:0046597 negative regulation of viral entry into host cell 0.00132627170636299 20 71 3 0.0422535211267606 0.15
GO:BP GO:0052547 regulation of peptidase activity 0.00138564554390901 467 28 6 0.214285714285714 0.012847965738758
GO:BP GO:0031349 positive regulation of defense response 0.0015399106570741 362 52 7 0.134615384615385 0.0193370165745856
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.00156268202140371 966 28 8 0.285714285714286 0.0082815734989648
GO:BP GO:0009892 negative regulation of metabolic process 0.00158290844236794 3479 23 13 0.565217391304348 0.00373670594998563
GO:BP GO:0012501 programmed cell death 0.00160933454290166 2143 53 17 0.320754716981132 0.00793280447970135
GO:BP GO:0001819 positive regulation of cytokine production 0.00163577684830493 452 90 10 0.111111111111111 0.0221238938053097
GO:BP GO:0009967 positive regulation of signal transduction 0.00168424909487885 1598 118 24 0.203389830508475 0.0150187734668335
GO:BP GO:0097190 apoptotic signaling pathway 0.0016864163938871 600 44 8 0.181818181818182 0.0133333333333333
GO:BP GO:0052126 movement in host environment 0.00179873613975085 177 108 7 0.0648148148148148 0.0395480225988701
GO:BP GO:0062208 positive regulation of pattern recognition receptor signaling pathway 0.00199322933620663 43 103 4 0.0388349514563107 0.0930232558139535
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 0.00210735708298861 75 60 4 0.0666666666666667 0.0533333333333333
GO:BP GO:0030218 erythrocyte differentiation 0.00210735708298861 116 15 3 0.2 0.0258620689655172
GO:BP GO:0002520 immune system development 0.00210735708298861 1020 28 8 0.285714285714286 0.00784313725490196
GO:BP GO:1902036 regulation of hematopoietic stem cell differentiation 0.00214057045294843 75 23 3 0.130434782608696 0.04
GO:BP GO:0032648 regulation of interferon-beta production 0.00219955942967012 52 88 4 0.0454545454545455 0.0769230769230769
GO:BP GO:0001961 positive regulation of cytokine-mediated signaling pathway 0.00222307918370513 50 92 4 0.0434782608695652 0.08
GO:BP GO:0034101 erythrocyte homeostasis 0.00244729649184733 124 15 3 0.2 0.0241935483870968
GO:BP GO:0032608 interferon-beta production 0.00247323000832604 54 88 4 0.0454545454545455 0.0740740740740741
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 0.00247673815606493 80 23 3 0.130434782608696 0.0375
GO:BP GO:0050777 negative regulation of immune response 0.00264988385573246 157 92 6 0.0652173913043478 0.0382165605095541
GO:BP GO:0035458 cellular response to interferon-beta 0.00270456986212392 21 91 3 0.032967032967033 0.142857142857143
GO:BP GO:0010647 positive regulation of cell communication 0.00291677307030852 1777 118 25 0.211864406779661 0.0140686550365785
GO:BP GO:0016567 protein ubiquitination 0.00294826501931275 892 61 11 0.180327868852459 0.0123318385650224
GO:BP GO:0023056 positive regulation of signaling 0.0030038285718199 1782 118 25 0.211864406779661 0.0140291806958474
GO:BP GO:0008219 cell death 0.00306083368152299 2292 53 17 0.320754716981132 0.00741710296684119
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.00306083368152299 567 39 7 0.179487179487179 0.0123456790123457
GO:BP GO:0032446 protein modification by small protein conjugation 0.00306083368152299 973 86 14 0.162790697674419 0.0143884892086331
GO:BP GO:0060218 hematopoietic stem cell differentiation 0.00309545279780966 89 23 3 0.130434782608696 0.0337078651685393
GO:BP GO:1901532 regulation of hematopoietic progenitor cell differentiation 0.00309545279780966 89 23 3 0.130434782608696 0.0337078651685393
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.00320589170774011 223 44 5 0.113636363636364 0.0224215246636771
GO:BP GO:0065009 regulation of molecular function 0.00347918118695568 3221 93 31 0.333333333333333 0.00962434026699783
GO:BP GO:0002262 myeloid cell homeostasis 0.00382471171144199 151 15 3 0.2 0.0198675496688742
GO:BP GO:1901222 regulation of NIK/NF-kappaB signaling 0.00394172923205211 113 90 5 0.0555555555555556 0.0442477876106195
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 0.00407268271711671 99 23 3 0.130434782608696 0.0303030303030303
GO:BP GO:0046700 heterocycle catabolic process 0.00411351225100644 602 39 7 0.179487179487179 0.0116279069767442
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.00434109740850959 608 39 7 0.179487179487179 0.0115131578947368
GO:BP GO:0010629 negative regulation of gene expression 0.0043660388060354 1460 23 8 0.347826086956522 0.00547945205479452
GO:BP GO:0006900 vesicle budding from membrane 0.00473805110038921 107 55 4 0.0727272727272727 0.0373831775700935
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.00476523322918764 1160 22 7 0.318181818181818 0.00603448275862069
GO:BP GO:0019439 aromatic compound catabolic process 0.00487490036753216 623 39 7 0.179487179487179 0.0112359550561798
GO:BP GO:1903706 regulation of hemopoiesis 0.00491564004663415 424 15 4 0.266666666666667 0.00943396226415094
GO:BP GO:0030099 myeloid cell differentiation 0.0050315442028709 428 15 4 0.266666666666667 0.00934579439252336
GO:BP GO:0062207 regulation of pattern recognition receptor signaling pathway 0.00543970679197877 108 103 5 0.0485436893203883 0.0462962962962963
GO:BP GO:0001818 negative regulation of cytokine production 0.00561704258404205 381 106 9 0.0849056603773585 0.0236220472440945
GO:BP GO:2000736 regulation of stem cell differentiation 0.00562376070518024 115 23 3 0.130434782608696 0.0260869565217391
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.00579475899341303 1184 86 15 0.174418604651163 0.0126689189189189
GO:BP GO:1901361 organic cyclic compound catabolic process 0.0058080147026538 651 39 7 0.179487179487179 0.010752688172043
GO:BP GO:0002230 positive regulation of defense response to virus by host 0.00582628981159754 33 81 3 0.037037037037037 0.0909090909090909
GO:BP GO:0016050 vesicle organization 0.00597112997178603 341 73 7 0.0958904109589041 0.0205278592375367
GO:BP GO:0051100 negative regulation of binding 0.00602303630525067 163 40 4 0.1 0.0245398773006135
GO:BP GO:0023051 regulation of signaling 0.00624908002627896 3578 45 19 0.422222222222222 0.00531022917831191
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.00629154081913153 240 28 4 0.142857142857143 0.0166666666666667
GO:BP GO:0002224 toll-like receptor signaling pathway 0.00675666728455933 161 113 6 0.0530973451327434 0.0372670807453416
GO:BP GO:0044265 cellular macromolecule catabolic process 0.00675666728455933 1231 59 12 0.203389830508475 0.00974817221770918
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 0.00691760524993275 162 113 6 0.0530973451327434 0.037037037037037
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.00758455606190257 159 44 4 0.0909090909090909 0.0251572327044025
GO:BP GO:0009966 regulation of signal transduction 0.00761799647918889 3165 108 33 0.305555555555556 0.0104265402843602
GO:BP GO:0032722 positive regulation of chemokine production 0.00814428504843528 63 113 4 0.0353982300884956 0.0634920634920635
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 0.00823167041222391 750 59 9 0.152542372881356 0.012
GO:BP GO:0044092 negative regulation of molecular function 0.00826674173970873 1219 53 11 0.207547169811321 0.00902378999179656
GO:BP GO:0061025 membrane fusion 0.00928960885155966 179 73 5 0.0684931506849315 0.0279329608938547
GO:BP GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 0.00944190165577665 73 103 4 0.0388349514563107 0.0547945205479452
GO:BP GO:0002683 negative regulation of immune system process 0.00950195954748106 420 106 9 0.0849056603773585 0.0214285714285714
GO:BP GO:0050790 regulation of catalytic activity 0.00956344149501608 2545 93 25 0.268817204301075 0.00982318271119843
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 0.00956344149501608 177 112 6 0.0535714285714286 0.0338983050847458
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 0.00987132555842268 172 45 4 0.0888888888888889 0.0232558139534884
GO:BP GO:0030162 regulation of proteolysis 0.00987132555842268 752 28 6 0.214285714285714 0.00797872340425532
GO:BP GO:2000106 regulation of leukocyte apoptotic process 0.00993415155683535 82 94 4 0.0425531914893617 0.0487804878048781
GO:BP GO:0050691 regulation of defense response to virus by host 0.0104848725804342 43 81 3 0.037037037037037 0.0697674418604651
GO:BP GO:0019941 modification-dependent protein catabolic process 0.0109063453197412 662 44 7 0.159090909090909 0.0105740181268882
GO:BP GO:0051239 regulation of multicellular organismal process 0.0109063453197412 2861 22 10 0.454545454545455 0.0034952813701503
GO:BP GO:0010646 regulation of cell communication 0.0114267178722765 3543 108 35 0.324074074074074 0.00987863392605137
GO:BP GO:0006508 proteolysis 0.0118409231497156 1836 44 12 0.272727272727273 0.0065359477124183
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 0.0118421377381284 673 44 7 0.159090909090909 0.0104011887072808
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.0120786159253623 1037 118 16 0.135593220338983 0.0154291224686596
GO:BP GO:0050789 regulation of biological process 0.0121406615106787 12091 23 22 0.956521739130435 0.00181953519146473
GO:BP GO:0048872 homeostasis of number of cells 0.012515535280052 261 15 3 0.2 0.0114942528735632
GO:BP GO:0044257 cellular protein catabolic process 0.012515535280052 813 59 9 0.152542372881356 0.011070110701107
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0126558003950751 8390 53 36 0.679245283018868 0.00429082240762813
GO:BP GO:1901565 organonitrogen compound catabolic process 0.0128996165086329 1358 59 12 0.203389830508475 0.00883652430044183
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 0.0137560544097764 174 23 3 0.130434782608696 0.0172413793103448
GO:BP GO:0002218 activation of innate immune response 0.0142263710615896 144 28 3 0.107142857142857 0.0208333333333333
GO:BP GO:0044248 cellular catabolic process 0.0149475615265664 2347 61 17 0.278688524590164 0.00724328930549638
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 0.0153072040514549 270 113 7 0.0619469026548673 0.0259259259259259
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.0153072040514549 182 23 3 0.130434782608696 0.0164835164835165
GO:BP GO:0002755 MyD88-dependent toll-like receptor signaling pathway 0.0156715487367022 37 113 3 0.0265486725663717 0.0810810810810811
GO:BP GO:0031348 negative regulation of defense response 0.0157613095455654 246 92 6 0.0652173913043478 0.024390243902439
GO:BP GO:2000107 negative regulation of leukocyte apoptotic process 0.0158945177667514 45 94 3 0.0319148936170213 0.0666666666666667
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.0168765053036641 192 23 3 0.130434782608696 0.015625
GO:BP GO:0035556 intracellular signal transduction 0.0170546055499865 2772 28 11 0.392857142857143 0.00396825396825397
GO:BP GO:0006401 RNA catabolic process 0.0172246327075224 424 23 4 0.173913043478261 0.00943396226415094
GO:BP GO:0043462 regulation of ATPase activity 0.0172246327075224 80 55 3 0.0545454545454545 0.0375
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.0197444390942606 456 113 9 0.079646017699115 0.0197368421052632
GO:BP GO:2000117 negative regulation of cysteine-type endopeptidase activity 0.0199083773184431 89 53 3 0.0566037735849057 0.0337078651685393
GO:BP GO:0009617 response to bacterium 0.0199591843432154 743 113 12 0.106194690265487 0.0161507402422611
GO:BP GO:0009057 macromolecule catabolic process 0.0199591843432154 1468 44 10 0.227272727272727 0.00681198910081744
GO:BP GO:0070555 response to interleukin-1 0.0199591843432154 215 113 6 0.0530973451327434 0.027906976744186
GO:BP GO:0043069 negative regulation of programmed cell death 0.0199591843432154 943 67 10 0.149253731343284 0.0106044538706257
GO:BP GO:0032755 positive regulation of interleukin-6 production 0.0199774178552042 89 113 4 0.0353982300884956 0.0449438202247191
GO:BP GO:0071887 leukocyte apoptotic process 0.02053431457029 108 94 4 0.0425531914893617 0.037037037037037
GO:BP GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 0.0215779270272206 45 112 3 0.0267857142857143 0.0666666666666667
GO:BP GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 0.0215779270272206 48 105 3 0.0285714285714286 0.0625
GO:BP GO:0032642 regulation of chemokine production 0.0225091666264256 94 113 4 0.0353982300884956 0.0425531914893617
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.022676768119072 155 113 5 0.0442477876106195 0.032258064516129
GO:BP GO:0070228 regulation of lymphocyte apoptotic process 0.0229078395604129 55 94 3 0.0319148936170213 0.0545454545454545
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.0229078395604129 187 28 3 0.107142857142857 0.0160427807486631
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.0229078395604129 306 112 7 0.0625 0.0228758169934641
GO:BP GO:0050793 regulation of developmental process 0.0237070378031653 2605 23 9 0.391304347826087 0.00345489443378119
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0237070378031653 2518 12 6 0.5 0.00238284352660842
GO:BP GO:0019882 antigen processing and presentation 0.0237070378031653 234 23 3 0.130434782608696 0.0128205128205128
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0239925302267447 6603 54 30 0.555555555555556 0.00454338936846888
GO:BP GO:0051098 regulation of binding 0.0243078612580635 365 50 5 0.1 0.0136986301369863
GO:BP GO:0033554 cellular response to stress 0.0243686238444641 2111 23 8 0.347826086956522 0.00378967314069162
GO:BP GO:0046822 regulation of nucleocytoplasmic transport 0.0244095696449883 115 47 3 0.0638297872340425 0.0260869565217391
GO:BP GO:1901575 organic substance catabolic process 0.0244279111605421 2267 46 13 0.282608695652174 0.00573445081605646
GO:BP GO:0045184 establishment of protein localization 0.0251495991591885 2035 69 16 0.231884057971014 0.00786240786240786
GO:BP GO:0065007 biological regulation 0.02546124783979 12809 23 22 0.956521739130435 0.00171754235303302
GO:BP GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 0.0256668805668972 95 59 3 0.0508474576271186 0.0315789473684211
GO:BP GO:0032602 chemokine production 0.0256668805668972 101 113 4 0.0353982300884956 0.0396039603960396
GO:BP GO:0045595 regulation of cell differentiation 0.0260973860580448 1679 23 7 0.304347826086957 0.00416914830256105
GO:BP GO:0010952 positive regulation of peptidase activity 0.0263140252524083 205 28 3 0.107142857142857 0.0146341463414634
GO:BP GO:0030163 protein catabolic process 0.0273167758082361 974 59 9 0.152542372881356 0.00924024640657084
GO:BP GO:0048863 stem cell differentiation 0.0275790058322117 258 23 3 0.130434782608696 0.0116279069767442
GO:BP GO:0034612 response to tumor necrosis factor 0.0293182862828773 331 112 7 0.0625 0.0211480362537764
GO:BP GO:0072527 pyrimidine-containing compound metabolic process 0.0295950604906843 84 72 3 0.0416666666666667 0.0357142857142857
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0297408619369294 2719 12 6 0.5 0.00220669363736668
GO:BP GO:0060548 negative regulation of cell death 0.0297408619369294 1038 67 10 0.149253731343284 0.00963391136801541
GO:BP GO:0010628 positive regulation of gene expression 0.0299446151785621 1160 90 13 0.144444444444444 0.0112068965517241
GO:BP GO:0010468 regulation of gene expression 0.030139290588526 5196 23 13 0.565217391304348 0.00250192455735181
GO:BP GO:0043170 macromolecule metabolic process 0.030404480580865 9796 54 39 0.722222222222222 0.00398121682319314
GO:BP GO:2000026 regulation of multicellular organismal development 0.030404480580865 1447 21 6 0.285714285714286 0.00414651002073255
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.030404480580865 655 44 6 0.136363636363636 0.00916030534351145
GO:BP GO:0010498 proteasomal protein catabolic process 0.0307306312825018 491 59 6 0.101694915254237 0.0122199592668024
GO:BP GO:0015031 protein transport 0.0313419843055821 1929 69 15 0.217391304347826 0.00777604976671851
GO:BP GO:0002253 activation of immune response 0.0319291463782617 568 52 6 0.115384615384615 0.0105633802816901
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.0319291463782617 1628 38 9 0.236842105263158 0.00552825552825553
GO:BP GO:0030522 intracellular receptor signaling pathway 0.0325365286572026 284 103 6 0.058252427184466 0.0211267605633803
GO:BP GO:0032757 positive regulation of interleukin-8 production 0.0325417305685845 58 113 3 0.0265486725663717 0.0517241379310345
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.0327235920736274 1337 38 8 0.210526315789474 0.00598354525056096
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.0328136810807504 1639 38 9 0.236842105263158 0.00549115314215985
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.0328136810807504 1339 38 8 0.210526315789474 0.00597460791635549
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.0329980922589285 1341 38 8 0.210526315789474 0.00596569724086503
GO:BP GO:0010648 negative regulation of cell communication 0.0331531396397689 1468 35 8 0.228571428571429 0.00544959128065395
GO:BP GO:0023057 negative regulation of signaling 0.0333972723823952 1471 35 8 0.228571428571429 0.00543847722637661
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.035023479945927 3483 92 28 0.304347826086957 0.00803904679873672
GO:BP GO:0043066 negative regulation of apoptotic process 0.035023479945927 921 67 9 0.134328358208955 0.00977198697068404
GO:BP GO:0009056 catabolic process 0.035023479945927 2744 46 14 0.304347826086957 0.00510204081632653
GO:BP GO:0015833 peptide transport 0.035023479945927 1971 69 15 0.217391304347826 0.0076103500761035
GO:BP GO:0007005 mitochondrion organization 0.0354312596750386 561 13 3 0.230769230769231 0.0053475935828877
GO:BP GO:0070227 lymphocyte apoptotic process 0.0354734574674747 74 94 3 0.0319148936170213 0.0405405405405405
GO:BP GO:0050852 T cell receptor signaling pathway 0.0359235302318208 203 106 5 0.0471698113207547 0.0246305418719212
GO:BP GO:0009968 negative regulation of signal transduction 0.0370178946203569 1364 6 3 0.5 0.00219941348973607
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.0374967356598572 4199 38 16 0.421052631578947 0.0038104310550131
GO:BP GO:0048523 negative regulation of cellular process 0.0375296627896147 5139 62 27 0.435483870967742 0.00525394045534151
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.0378570281979608 1707 38 9 0.236842105263158 0.00527240773286467
GO:BP GO:0042127 regulation of cell population proliferation 0.037934459793634 1774 9 4 0.444444444444444 0.00225479143179256
GO:BP GO:0002699 positive regulation of immune effector process 0.037934459793634 215 103 5 0.0485436893203883 0.0232558139534884
GO:BP GO:0043112 receptor metabolic process 0.037934459793634 174 81 4 0.0493827160493827 0.0229885057471264
GO:BP GO:0006974 cellular response to DNA damage stimulus 0.037934459793634 888 59 8 0.135593220338983 0.00900900900900901
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.037934459793634 323 44 4 0.0909090909090909 0.0123839009287926
GO:BP GO:1902531 regulation of intracellular signal transduction 0.037934459793634 1842 118 21 0.177966101694915 0.011400651465798
GO:BP GO:0010467 gene expression 0.037934459793634 6179 23 14 0.608695652173913 0.0022657387926849
GO:BP GO:0042886 amide transport 0.037934459793634 2007 69 15 0.217391304347826 0.00747384155455904
GO:BP GO:0006986 response to unfolded protein 0.0388845297095774 184 78 4 0.0512820512820513 0.0217391304347826
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0389169025113678 790 19 4 0.210526315789474 0.00506329113924051
GO:BP GO:0001960 negative regulation of cytokine-mediated signaling pathway 0.0394780318375685 82 92 3 0.0326086956521739 0.0365853658536585
GO:BP GO:1900182 positive regulation of protein localization to nucleus 0.0396206304656275 90 84 3 0.0357142857142857 0.0333333333333333
GO:BP GO:0009890 negative regulation of biosynthetic process 0.0396206304656275 1740 38 9 0.236842105263158 0.00517241379310345
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0396206304656275 5746 54 26 0.481481481481481 0.00452488687782805
GO:BP GO:0018130 heterocycle biosynthetic process 0.0399095953595347 4269 38 16 0.421052631578947 0.003747950339658
GO:BP GO:0032880 regulation of protein localization 0.0403274589868972 922 108 12 0.111111111111111 0.0130151843817787
GO:BP GO:0019438 aromatic compound biosynthetic process 0.0405226196580495 4278 38 16 0.421052631578947 0.0037400654511454
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0409643585367333 1445 38 8 0.210526315789474 0.0055363321799308
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0420594238563076 547 15 3 0.2 0.00548446069469835
GO:BP GO:0050848 regulation of calcium-mediated signaling 0.0424365564702879 75 106 3 0.0283018867924528 0.04
GO:BP GO:0060761 negative regulation of response to cytokine stimulus 0.0436614055497675 88 92 3 0.0326086956521739 0.0340909090909091
GO:BP GO:0050794 regulation of cellular process 0.0441467602167878 11473 10 10 1 0.000871611609866643
GO:BP GO:0090304 nucleic acid metabolic process 0.0441659954365395 5226 54 24 0.444444444444444 0.00459242250287026
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0441659954365395 982 9 3 0.333333333333333 0.00305498981670061
GO:BP GO:0044237 cellular metabolic process 0.0441659954365395 10871 54 41 0.759259259259259 0.00377150216171465
GO:BP GO:0048524 positive regulation of viral process 0.0441801420399151 91 90 3 0.0333333333333333 0.032967032967033
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 0.0441801420399151 901 38 6 0.157894736842105 0.00665926748057714
GO:BP GO:0019222 regulation of metabolic process 0.0441866910601891 7148 39 23 0.58974358974359 0.00321768326804701
GO:BP GO:0042981 regulation of apoptotic process 0.044271801783699 1549 67 12 0.17910447761194 0.00774693350548741
GO:BP GO:0009893 positive regulation of metabolic process 0.0447469399607202 3783 92 29 0.315217391304348 0.00766587364525509
GO:BP GO:0006611 protein export from nucleus 0.0447469399607202 185 45 3 0.0666666666666667 0.0162162162162162
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0447469399607202 5848 54 26 0.481481481481481 0.00444596443228454
GO:BP GO:0034504 protein localization to nucleus 0.0451389889560321 289 84 5 0.0595238095238095 0.0173010380622837
GO:BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0451556733873541 96 87 3 0.0344827586206897 0.03125
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0452292148615098 5017 23 12 0.521739130434783 0.00239186764999003
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0458674199925562 363 44 4 0.0909090909090909 0.0110192837465565
GO:BP GO:0043086 negative regulation of catalytic activity 0.0460021856522796 851 53 7 0.132075471698113 0.0082256169212691
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0460602982933636 477 52 5 0.0961538461538462 0.010482180293501
GO:BP GO:0002757 immune response-activating signal transduction 0.0460602982933636 477 52 5 0.0961538461538462 0.010482180293501
GO:BP GO:0035966 response to topologically incorrect protein 0.0462500016114487 205 78 4 0.0512820512820513 0.0195121951219512
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0462500016114487 470 53 5 0.0943396226415094 0.0106382978723404
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.0462500016114487 141 113 4 0.0353982300884956 0.0283687943262411
GO:BP GO:0051252 regulation of RNA metabolic process 0.0462500016114487 3822 54 19 0.351851851851852 0.00497121925693354
GO:BP GO:0046483 heterocycle metabolic process 0.0462500016114487 5904 39 20 0.512820512820513 0.00338753387533875
GO:BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 0.0463792472150727 77 112 3 0.0267857142857143 0.038961038961039
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.0463792472150727 142 113 4 0.0353982300884956 0.028169014084507
GO:BP GO:0006402 mRNA catabolic process 0.0464331049486831 384 23 3 0.130434782608696 0.0078125
GO:BP GO:0007259 receptor signaling pathway via JAK-STAT 0.0465463464157194 174 50 3 0.06 0.0172413793103448
GO:BP GO:0043067 regulation of programmed cell death 0.0471326483207254 1582 67 12 0.17910447761194 0.00758533501896334
GO:BP GO:0016070 RNA metabolic process 0.0477254426373312 4710 54 22 0.407407407407407 0.00467091295116773
GO:BP GO:0002821 positive regulation of adaptive immune response 0.0477254426373312 101 87 3 0.0344827586206897 0.0297029702970297
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0477254426373312 4439 23 11 0.478260869565217 0.00247803559360216
GO:BP GO:0008283 cell population proliferation 0.0484156317555243 2054 9 4 0.444444444444444 0.00194741966893866
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0487921274700601 5956 39 20 0.512820512820513 0.00335795836131632
GO:BP GO:0006913 nucleocytoplasmic transport 0.0488001399477796 354 47 4 0.0851063829787234 0.0112994350282486
GO:BP GO:0032088 negative regulation of NF-kappaB transcription factor activity 0.0488954099242329 97 92 3 0.0326086956521739 0.0309278350515464
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.0492840453275905 434 59 5 0.0847457627118644 0.0115207373271889
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 0.0493188294010156 1548 38 8 0.210526315789474 0.00516795865633075
GO:BP GO:0051169 nuclear transport 0.0495111876187297 357 47 4 0.0851063829787234 0.0112044817927171
GO:CC GO:0005829 cytosol 3.16448668188681e-06 5303 62 39 0.629032258064516 0.00735432773901565
GO:CC GO:0005737 cytoplasm 0.00279825397236926 11911 101 83 0.821782178217822 0.00696834858534128
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00681472127587171 11296 93 73 0.78494623655914 0.00646246458923513
GO:CC GO:0048471 perinuclear region of cytoplasm 0.00756051134972281 735 101 13 0.128712871287129 0.017687074829932
GO:CC GO:0005634 nucleus 0.00756051134972281 7592 93 55 0.591397849462366 0.00724446786090622
GO:CC GO:0022626 cytosolic ribosome 0.00756051134972281 109 19 3 0.157894736842105 0.0275229357798165
GO:CC GO:0005768 endosome 0.00938338950041115 987 113 16 0.141592920353982 0.0162107396149949
GO:CC GO:0097708 intracellular vesicle 0.0185461981236477 2428 113 27 0.238938053097345 0.0111202635914333
GO:CC GO:0031410 cytoplasmic vesicle 0.0185461981236477 2424 113 27 0.238938053097345 0.0111386138613861
GO:CC GO:0010008 endosome membrane 0.0185461981236477 505 113 10 0.0884955752212389 0.0198019801980198
GO:CC GO:0045335 phagocytic vesicle 0.0220398971688524 137 108 5 0.0462962962962963 0.0364963503649635
GO:CC GO:0005840 ribosome 0.026666432174591 245 19 3 0.157894736842105 0.0122448979591837
GO:CC GO:0012505 endomembrane system 0.0305569875943049 4640 114 42 0.368421052631579 0.00905172413793104
GO:CC GO:0005654 nucleoplasm 0.0317712305209844 4102 81 29 0.358024691358025 0.00706972208678693
GO:CC GO:0043229 intracellular organelle 0.0345096964258634 12491 93 74 0.795698924731183 0.00592426547113922
GO:CC GO:0043227 membrane-bounded organelle 0.0411037942529633 12858 93 75 0.806451612903226 0.00583294447036864
GO:CC GO:0005622 intracellular anatomical structure 0.0411037942529633 14790 93 83 0.89247311827957 0.00561189993238675
GO:CC GO:0031981 nuclear lumen 0.0411037942529633 4444 61 24 0.39344262295082 0.0054005400540054
GO:CC GO:0005770 late endosome 0.0461616956975771 275 112 6 0.0535714285714286 0.0218181818181818
GO:CC GO:0005635 nuclear envelope 0.0461616956975771 467 47 5 0.106382978723404 0.0107066381156317
GO:CC GO:0070013 intracellular organelle lumen 0.0461616956975771 5402 58 26 0.448275862068966 0.00481303221029248
GO:CC GO:0005794 Golgi apparatus 0.0470640681193624 1623 95 16 0.168421052631579 0.00985828712261245
GO:CC GO:0005769 early endosome 0.0487996120342801 378 85 6 0.0705882352941176 0.0158730158730159
GO:MF GO:0003725 double-stranded RNA binding 5.89196883322072e-09 77 103 10 0.0970873786407767 0.12987012987013
GO:MF GO:0001730 2'-5'-oligoadenylate synthetase activity 5.54469450545931e-08 4 76 4 0.0526315789473684 1
GO:MF GO:1990404 protein ADP-ribosylase activity 0.000106750921344528 16 86 4 0.0465116279069767 0.25
GO:MF GO:0042802 identical protein binding 0.000209377700644743 2067 44 17 0.386363636363636 0.00822447992259313
GO:MF GO:0003950 NAD+ ADP-ribosyltransferase activity 0.000495180641023427 27 86 4 0.0465116279069767 0.148148148148148
GO:MF GO:0016763 transferase activity, transferring pentosyl groups 0.000495180641023427 56 86 5 0.0581395348837209 0.0892857142857143
GO:MF GO:0070566 adenylyltransferase activity 0.000518665924715661 33 76 4 0.0526315789473684 0.121212121212121
GO:MF GO:0003727 single-stranded RNA binding 0.000574484664277409 92 103 6 0.058252427184466 0.0652173913043478
GO:MF GO:0003724 RNA helicase activity 0.00274465330773809 76 103 5 0.0485436893203883 0.0657894736842105
GO:MF GO:0042803 protein homodimerization activity 0.0029829243324293 676 21 6 0.285714285714286 0.00887573964497041
GO:MF GO:0046983 protein dimerization activity 0.00404930274254224 1069 15 6 0.4 0.00561272217025257
GO:MF GO:0032813 tumor necrosis factor receptor superfamily binding 0.0073528801547721 49 113 4 0.0353982300884956 0.0816326530612245
GO:MF GO:0016740 transferase activity 0.00851977259110979 2357 91 24 0.263736263736264 0.010182435299109
GO:MF GO:0003723 RNA binding 0.00852647951725565 1943 103 23 0.223300970873786 0.0118373648996397
GO:MF GO:0005164 tumor necrosis factor receptor binding 0.0106877036203475 32 87 3 0.0344827586206897 0.09375
GO:MF GO:0005515 protein binding 0.011023402519976 14767 52 50 0.961538461538462 0.00338592808288752
GO:MF GO:0016779 nucleotidyltransferase activity 0.011023402519976 135 91 5 0.0549450549450549 0.037037037037037
GO:MF GO:0004842 ubiquitin-protein transferase activity 0.0114393908166142 442 61 7 0.114754098360656 0.0158371040723982
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.012311647546964 314 11 3 0.272727272727273 0.00955414012738853
GO:MF GO:0019787 ubiquitin-like protein transferase activity 0.0130547211922882 465 61 7 0.114754098360656 0.0150537634408602
GO:MF GO:0017076 purine nucleotide binding 0.0175837688611653 1933 106 22 0.207547169811321 0.0113812726332126
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 0.0202664470021146 1847 106 21 0.19811320754717 0.0113697888467786
GO:MF GO:0140098 catalytic activity, acting on RNA 0.020494238810784 395 103 8 0.0776699029126214 0.020253164556962
GO:MF GO:0003714 transcription corepressor activity 0.0222277010913018 187 86 5 0.0581395348837209 0.0267379679144385
GO:MF GO:0004386 helicase activity 0.0245223562413623 162 103 5 0.0485436893203883 0.0308641975308642
GO:MF GO:1901265 nucleoside phosphate binding 0.0245223562413623 2172 106 23 0.216981132075472 0.0105893186003683
GO:MF GO:0032555 purine ribonucleotide binding 0.0245223562413623 1918 106 21 0.19811320754717 0.0109489051094891
GO:MF GO:0000166 nucleotide binding 0.0245223562413623 2171 106 23 0.216981132075472 0.0105941962229387
GO:MF GO:0032553 ribonucleotide binding 0.0254673524349894 1935 106 21 0.19811320754717 0.0108527131782946
GO:MF GO:0036094 small molecule binding 0.0281373907933831 2506 106 25 0.235849056603774 0.00997605746209098
GO:MF GO:0097367 carbohydrate derivative binding 0.0358420237536737 2285 106 23 0.216981132075472 0.0100656455142232
GO:MF GO:1901363 heterocyclic compound binding 0.0417004960782822 6228 92 43 0.467391304347826 0.00690430314707771
GO:MF GO:0004518 nuclease activity 0.0420657018429563 207 104 5 0.0480769230769231 0.0241545893719807
GO:MF GO:0030554 adenyl nucleotide binding 0.0420657018429563 1578 103 17 0.16504854368932 0.0107731305449937
GO:MF GO:0097159 organic cyclic compound binding 0.0421017358185899 6309 92 43 0.467391304347826 0.00681566016801395
GO:MF GO:0003824 catalytic activity 0.0438465168025808 5896 91 40 0.43956043956044 0.0067842605156038
GO:MF GO:0061630 ubiquitin protein ligase activity 0.0438465168025808 305 108 6 0.0555555555555556 0.019672131147541
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.0438465168025808 281 81 5 0.0617283950617284 0.0177935943060498
GO:MF GO:0043168 anion binding 0.0438465168025808 2418 106 23 0.216981132075472 0.00951199338296112
GO:MF GO:0003712 transcription coregulator activity 0.0438465168025808 506 86 7 0.0813953488372093 0.0138339920948617
GO:MF GO:0003676 nucleic acid binding 0.0438465168025808 4276 104 35 0.336538461538462 0.00818521983161834
GO:MF GO:0005524 ATP binding 0.0438465168025808 1501 103 16 0.155339805825243 0.0106595602931379
GO:MF GO:0008270 zinc ion binding 0.0438465168025808 833 108 11 0.101851851851852 0.0132052821128451
GO:MF GO:0008134 transcription factor binding 0.0438905128168405 676 81 8 0.0987654320987654 0.0118343195266272
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.046667830870751 283 86 5 0.0581395348837209 0.0176678445229682
GO:MF GO:0061659 ubiquitin-like protein ligase activity 0.0472544776962374 316 108 6 0.0555555555555556 0.0189873417721519
GO:MF GO:0140096 catalytic activity, acting on a protein 0.0489478270661842 2332 64 15 0.234375 0.00643224699828473
GO:MF GO:0004527 exonuclease activity 0.0498704561887618 84 104 3 0.0288461538461538 0.0357142857142857
GO:MF GO:0032559 adenyl ribonucleotide binding 0.0498704561887618 1565 103 16 0.155339805825243 0.010223642172524
HP HP:0030354 Abnormal serum interferon level 0.021319522240637 11 83 4 0.0481927710843374 0.363636363636364
HP HP:0030355 Abnormal serum interferon-gamma level 0.021319522240637 11 83 4 0.0481927710843374 0.363636363636364
KEGG KEGG:05164 Influenza A 2.05198192964259e-07 169 83 14 0.168674698795181 0.0828402366863905
KEGG KEGG:05160 Hepatitis C 7.07589826624176e-07 157 58 11 0.189655172413793 0.0700636942675159
KEGG KEGG:05162 Measles 7.07589826624176e-07 139 83 12 0.144578313253012 0.0863309352517986
KEGG KEGG:05171 Coronavirus disease - COVID-19 9.83011277506003e-06 231 54 11 0.203703703703704 0.0476190476190476
KEGG KEGG:05169 Epstein-Barr virus infection 4.72333972605917e-05 198 60 10 0.166666666666667 0.0505050505050505
KEGG KEGG:04621 NOD-like receptor signaling pathway 0.000149608454825394 177 113 12 0.106194690265487 0.0677966101694915
KEGG KEGG:05168 Herpes simplex virus 1 infection 0.00341154160250048 494 21 7 0.333333333333333 0.01417004048583
KEGG KEGG:04217 Necroptosis 0.00577704857231311 159 48 6 0.125 0.0377358490566038
KEGG KEGG:05165 Human papillomavirus infection 0.0450819386893425 331 8 3 0.375 0.00906344410876133
MIRNA MIRNA:hsa-miR-146a-5p hsa-miR-146a-5p 7.20695222421491e-11 200 76 15 0.197368421052632 0.075
REAC REAC:R-HSA-913531 Interferon Signaling 5.28900962992679e-31 191 108 34 0.314814814814815 0.178010471204188
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 8.0148956486272e-30 66 76 22 0.289473684210526 0.333333333333333
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 3.80878145716747e-15 842 62 30 0.483870967741935 0.0356294536817102
REAC REAC:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 3.12462439305311e-13 78 54 12 0.222222222222222 0.153846153846154
REAC REAC:R-HSA-877300 Interferon gamma signaling 2.98613761843054e-10 87 108 13 0.12037037037037 0.149425287356322
REAC REAC:R-HSA-168256 Immune System 6.87545290910359e-10 2139 92 48 0.521739130434783 0.0224403927068724
REAC REAC:R-HSA-1169408 ISG15 antiviral mechanism 9.83827635636043e-10 70 47 9 0.191489361702128 0.128571428571429
REAC REAC:R-HSA-8983711 OAS antiviral response 1.60109616018313e-05 9 76 4 0.0526315789473684 0.444444444444444
REAC REAC:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.000190847643890698 76 92 7 0.0760869565217391 0.0921052631578947
REAC REAC:R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 0.000432904542110781 34 92 5 0.0543478260869565 0.147058823529412
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.00150370171921987 370 60 10 0.166666666666667 0.027027027027027
REAC REAC:R-HSA-9683610 Maturation of nucleoprotein 0.00210693441747048 10 86 3 0.0348837209302326 0.3
REAC REAC:R-HSA-196807 Nicotinate metabolism 0.00353772918254157 31 86 4 0.0465116279069767 0.129032258064516
REAC REAC:R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.00878883556762774 308 59 8 0.135593220338983 0.025974025974026
REAC REAC:R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 0.0111845860004657 14 113 3 0.0265486725663717 0.214285714285714
REAC REAC:R-HSA-8939902 Regulation of RUNX2 expression and activity 0.0112333809500406 71 23 3 0.130434782608696 0.0422535211267606
REAC REAC:R-HSA-197264 Nicotinamide salvaging 0.0112333809500406 19 86 3 0.0348837209302326 0.157894736842105
REAC REAC:R-HSA-1236974 ER-Phagosome pathway 0.0155800995784231 83 23 3 0.130434782608696 0.036144578313253
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 0.0236350288037883 99 23 3 0.130434782608696 0.0303030303030303
REAC REAC:R-HSA-168249 Innate Immune System 0.0237948314327795 1073 28 9 0.321428571428571 0.00838769804287046
REAC REAC:R-HSA-9683701 Translation of structural proteins 0.0258649537074749 28 86 3 0.0348837209302326 0.107142857142857
REAC REAC:R-HSA-8878166 Transcriptional regulation by RUNX2 0.0322956860854505 118 23 3 0.130434782608696 0.0254237288135593
REAC REAC:R-HSA-162909 Host Interactions of HIV factors 0.0338391020233194 125 23 3 0.130434782608696 0.024
REAC REAC:R-HSA-168255 Influenza Infection 0.0338391020233194 152 19 3 0.157894736842105 0.0197368421052632
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.0411388725492681 800 60 11 0.183333333333333 0.01375
REAC REAC:R-HSA-9679506 SARS-CoV Infections 0.0411388725492681 85 86 4 0.0465116279069767 0.0470588235294118
REAC REAC:R-HSA-196849 Metabolism of water-soluble vitamins and cofactors 0.0411388725492681 120 104 5 0.0480769230769231 0.0416666666666667
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 0.0411388725492681 171 23 3 0.130434782608696 0.0175438596491228
REAC REAC:R-HSA-162906 HIV Infection 0.0411388725492681 226 29 4 0.137931034482759 0.0176991150442478
REAC REAC:R-HSA-5663205 Infectious disease 0.0411388725492681 815 35 8 0.228571428571429 0.0098159509202454
REAC REAC:R-HSA-157118 Signaling by NOTCH 0.0413039672713961 197 23 3 0.130434782608696 0.0152284263959391
REAC REAC:R-HSA-9678108 SARS-CoV-1 Infection 0.0413039672713961 50 86 3 0.0348837209302326 0.06
REAC REAC:R-HSA-109581 Apoptosis 0.0413039672713961 174 27 3 0.111111111111111 0.0172413793103448
REAC REAC:R-HSA-5357801 Programmed Cell Death 0.0419104727953986 177 27 3 0.111111111111111 0.0169491525423729
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 0.04354774848968 217 23 3 0.130434782608696 0.0138248847926267
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 4.12598879341629e-32 1617 119 62 0.521008403361345 0.0383426097711812
TF TF:M11685_1 Factor: IRF-8; motif: NCGAAACYGAAACYN; match class: 1 7.45992619216301e-29 118 117 25 0.213675213675214 0.211864406779661
TF TF:M04020 Factor: IRF8; motif: NCGAAACCGAAACT 5.5501764743032e-28 992 108 46 0.425925925925926 0.0463709677419355
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 1.16514748881701e-27 1651 108 55 0.509259259259259 0.033313143549364
TF TF:M10080 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN 3.64430956701981e-26 356 105 31 0.295238095238095 0.0870786516853933
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 5.458228572644e-26 2396 119 65 0.546218487394958 0.0271285475792988
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 1.8515244349648e-25 272 117 29 0.247863247863248 0.106617647058824
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 2.59617009087781e-25 1267 106 47 0.443396226415094 0.037095501183899
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 2.73414458825269e-25 278 117 29 0.247863247863248 0.10431654676259
TF TF:M11670 Factor: IRF-5; motif: NYGAAACCGAAACY 4.61555843444805e-25 871 108 41 0.37962962962963 0.0470723306544202
TF TF:M11671 Factor: IRF-5; motif: NCGAAACCGAAACY 5.19472880653789e-25 389 117 32 0.273504273504274 0.0822622107969152
TF TF:M09733 Factor: STAT2; motif: NRGAAANNGAAACTNA 9.04090086022342e-24 2842 119 67 0.563025210084034 0.0235749472202674
TF TF:M07216 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT 1.31537312957717e-23 440 106 31 0.292452830188679 0.0704545454545455
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 2.56916484226186e-23 622 117 36 0.307692307692308 0.0578778135048231
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 1.023682406107e-22 2761 110 62 0.563636363636364 0.022455632017385
TF TF:M11686 Factor: IRF-4; motif: NYGAAASYGAAACYN 6.56664830757844e-22 3391 108 66 0.611111111111111 0.0194632851666175
TF TF:M11687_1 Factor: IRF-4; motif: NCGAAACCGAAACYN; match class: 1 6.62021791294896e-22 474 103 30 0.29126213592233 0.0632911392405063
TF TF:M04015 Factor: IRF-4; motif: NCGAAACCGAAACYA 8.54977734688499e-22 2038 108 53 0.490740740740741 0.0260058881256133
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 9.87300324348614e-22 3795 108 69 0.638888888888889 0.0181818181818182
TF TF:M04018 Factor: IRF7; motif: NCGAAARYGAAANT 1.17058726091969e-21 619 106 33 0.311320754716981 0.0533117932148627
TF TF:M11681 Factor: IRF-9; motif: NCGAAACYGAAACYN 1.54012867196679e-21 97 117 19 0.162393162393162 0.195876288659794
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 1.9064588105479e-21 3595 108 67 0.62037037037037 0.0186369958275382
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 3.79817168348985e-21 3082 122 67 0.549180327868853 0.0217391304347826
TF TF:M11680 Factor: IRF-9; motif: NYGAAACYGAAACYN 9.99857074218682e-21 128 117 20 0.170940170940171 0.15625
TF TF:M04020_1 Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 1.13626585107495e-20 45 117 15 0.128205128205128 0.333333333333333
TF TF:M11683_1 Factor: IRF-8; motif: NCGAAACCGAAACYN; match class: 1 1.13626585107495e-20 814 103 35 0.339805825242718 0.042997542997543
TF TF:M08887_1 Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 1.3151311621784e-20 73 117 17 0.145299145299145 0.232876712328767
TF TF:M11672 Factor: IRF-5; motif: NCGAAACCGAAACY 8.6515072526401e-20 120 117 19 0.162393162393162 0.158333333333333
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 1.16792701603072e-19 4690 108 73 0.675925925925926 0.0155650319829424
TF TF:M11664_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 1.32535681451114e-19 140 103 19 0.184466019417476 0.135714285714286
TF TF:M00699 Factor: ICSBP; motif: RAARTGAAACTG 1.53973945406643e-19 1184 119 42 0.352941176470588 0.035472972972973
TF TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 2.87240546894317e-19 823 119 36 0.302521008403361 0.0437424058323208
TF TF:M04788 Factor: IRF-1; motif: STTTCACTTTCNNT 4.54369408711359e-19 536 106 29 0.273584905660377 0.0541044776119403
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 4.69221333790721e-19 4664 108 72 0.666666666666667 0.0154373927958834
TF TF:M11665_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 5.18215605555464e-19 246 117 23 0.196581196581197 0.0934959349593496
TF TF:M04015_1 Factor: IRF-4; motif: NCGAAACCGAAACYA; match class: 1 5.32402113604517e-19 158 117 20 0.170940170940171 0.126582278481013
TF TF:M11684_1 Factor: IRF-8; motif: NYGAAACYGAAACTN; match class: 1 5.6346702678966e-19 832 106 34 0.320754716981132 0.0408653846153846
TF TF:M11682_1 Factor: IRF-8; motif: NYGAAASYGAAACYN; match class: 1 5.65160193860444e-19 543 106 29 0.273584905660377 0.0534069981583794
TF TF:M00453_1 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 1.01848983954048e-18 332 103 24 0.233009708737864 0.072289156626506
TF TF:M09733_1 Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 1.05478054617675e-18 367 117 26 0.222222222222222 0.0708446866485014
TF TF:M11670_1 Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 1.80941789864899e-18 36 117 13 0.111111111111111 0.361111111111111
TF TF:M11677 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN 2.75767458981038e-18 470 117 28 0.239316239316239 0.0595744680851064
TF TF:M11686_1 Factor: IRF-4; motif: NYGAAASYGAAACYN; match class: 1 8.387015430388e-17 452 103 25 0.242718446601942 0.0553097345132743
TF TF:M04016 Factor: IRF5; motif: CCGAAACCGAAACY 1.04365719548551e-16 314 117 23 0.196581196581197 0.0732484076433121
TF TF:M11679_1 Factor: IRF-7; motif: NCGAAANCGAAANYN; match class: 1 1.08043403719529e-15 23 100 10 0.1 0.434782608695652
TF TF:M09956 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN 1.96447953934073e-15 317 117 22 0.188034188034188 0.0694006309148265
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 2.3741047906798e-15 1029 119 35 0.294117647058824 0.0340136054421769
TF TF:M00699_1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 6.18071423985538e-15 47 117 12 0.102564102564103 0.25531914893617
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 8.40744138940206e-15 535 106 25 0.235849056603774 0.0467289719626168
TF TF:M07323 Factor: IRF-4; motif: KRAAMNGAAANYN 8.61343015830475e-15 938 119 33 0.277310924369748 0.035181236673774
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 8.21395323684809e-14 562 111 25 0.225225225225225 0.0444839857651246
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 1.51852557089593e-13 336 106 20 0.188679245283019 0.0595238095238095
TF TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 1.78419400868496e-12 8370 92 75 0.815217391304348 0.00896057347670251
TF TF:M11673 Factor: IRF-5; motif: NCGAAACCGAAACY 3.41517006528186e-12 57 117 11 0.094017094017094 0.192982456140351
TF TF:M00258_1 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC; match class: 1 9.89295143373327e-12 30 117 9 0.0769230769230769 0.3
TF TF:M00772_1 Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 1.41261501825964e-10 57 117 10 0.0854700854700855 0.175438596491228
TF TF:M00972_1 Factor: IRF; motif: RAAANTGAAAN; match class: 1 5.59086284332558e-10 205 106 14 0.132075471698113 0.0682926829268293
TF TF:M10080_1 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN; match class: 1 7.22553091492792e-10 11 100 6 0.06 0.545454545454545
TF TF:M00972 Factor: IRF; motif: RAAANTGAAAN 1.47489085173325e-09 1979 110 37 0.336363636363636 0.0186963112683173
TF TF:M09958 Factor: IRF-3; motif: RAAARGGAAANNGAAASNGA 2.50607412700765e-09 589 103 20 0.194174757281553 0.033955857385399
TF TF:M04788_1 Factor: IRF-1; motif: STTTCACTTTCNNT; match class: 1 8.80018524662847e-09 17 89 6 0.0674157303370786 0.352941176470588
TF TF:M09745 Factor: HELIOS; motif: RNARRRGGAASTGARAN 1.06296920034607e-08 3582 96 45 0.46875 0.0125628140703518
TF TF:M09957_1 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN; match class: 1 5.04508917987578e-08 22 89 6 0.0674157303370786 0.272727272727273
TF TF:M11680_1 Factor: IRF-9; motif: NYGAAACYGAAACYN; match class: 1 6.95347379816735e-08 4 103 4 0.0388349514563107 1
TF TF:M11671_1 Factor: IRF-5; motif: NCGAAACCGAAACY; match class: 1 6.62959111291649e-07 14 103 5 0.0485436893203883 0.357142857142857
TF TF:M00063 Factor: IRF-2; motif: GAAAAGYGAAASY 6.88715016092718e-07 685 77 16 0.207792207792208 0.0233576642335766
TF TF:M00062 Factor: IRF-1; motif: SAAAAGYGAAACC 1.42964474587125e-06 576 32 10 0.3125 0.0173611111111111
TF TF:M04016_1 Factor: IRF5; motif: CCGAAACCGAAACY; match class: 1 7.54184912824978e-06 8 117 4 0.0341880341880342 0.5
TF TF:M07323_1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 9.79302641592587e-06 39 117 6 0.0512820512820513 0.153846153846154
TF TF:M11677_1 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN; match class: 1 1.49962645041817e-05 26 98 5 0.0510204081632653 0.192307692307692
TF TF:M00459_1 Factor: STAT5B; motif: NAWTTCYNGGAAWTN; match class: 1 2.58255725154453e-05 1896 59 20 0.338983050847458 0.0105485232067511
TF TF:M11674 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC 3.23951382000817e-05 4623 62 33 0.532258064516129 0.00713822193380921
TF TF:M01279 Factor: IRF-3; motif: NBNBTTTCSCTTT 7.54768396292379e-05 1647 103 25 0.242718446601942 0.0151791135397693
TF TF:M11676_1 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN; match class: 1 7.95730390581529e-05 41 86 5 0.0581395348837209 0.121951219512195
TF TF:M04017 Factor: IRF5; motif: NACCGAAACYA 0.000106876418663953 195 108 9 0.0833333333333333 0.0461538461538462
TF TF:M07045_1 Factor: IRF-1; motif: NNRAAANNGAAASN; match class: 1 0.000113733610695817 19 88 4 0.0454545454545455 0.210526315789474
TF TF:M01665 Factor: IRF-8; motif: AGTTTCW 0.000186554583566932 4771 119 52 0.436974789915966 0.0108991825613079
TF TF:M00225_1 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN; match class: 1 0.000199949534756309 1922 55 18 0.327272727272727 0.00936524453694069
TF TF:M03875 Factor: IRF-5; motif: KTTTCGCTTTCMT 0.000207856044925967 100 77 6 0.0779220779220779 0.06
TF TF:M09956_1 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN; match class: 1 0.000254760764727429 23 89 4 0.0449438202247191 0.173913043478261
TF TF:M00457_1 Factor: STAT5A; motif: NAWTTCYNGGAANYN; match class: 1 0.000302054645215631 1589 43 14 0.325581395348837 0.00881057268722467
TF TF:M09745_1 Factor: HELIOS; motif: RNARRRGGAASTGARAN; match class: 1 0.000364023644595596 495 65 10 0.153846153846154 0.0202020202020202
TF TF:M07228 Factor: STAT1; motif: NTTCYRGGAAA 0.000830466608843673 1919 55 17 0.309090909090909 0.0088587806149036
TF TF:M04014_1 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR; match class: 1 0.000857713500155489 9 103 3 0.029126213592233 0.333333333333333
TF TF:M10079_1 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC; match class: 1 0.00104490993667124 1164 55 13 0.236363636363636 0.0111683848797251
TF TF:M07216_1 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT; match class: 1 0.00134455084460395 35 89 4 0.0449438202247191 0.114285714285714
TF TF:M08295_1 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM; match class: 1 0.00157373381656447 4997 110 48 0.436363636363636 0.00960576345807485
TF TF:M09664_1 Factor: STAT3; motif: NTTCCYGGAAN; match class: 1 0.00182283250623635 1875 43 14 0.325581395348837 0.00746666666666667
TF TF:M01665_1 Factor: IRF-8; motif: AGTTTCW; match class: 1 0.00182283250623635 721 118 15 0.127118644067797 0.0208044382801664
TF TF:M09663 Factor: STAT1; motif: YCMTTTCCNGGAAAWCNCATNN 0.00182283250623635 2762 59 21 0.355932203389831 0.00760318609703114
TF TF:M00457 Factor: STAT5A; motif: NAWTTCYNGGAANYN 0.00207965998535117 4038 43 21 0.488372093023256 0.00520059435364042
TF TF:M00459 Factor: STAT5B; motif: NAWTTCYNGGAAWTN 0.00226033857057656 3076 43 18 0.418604651162791 0.005851755526658
TF TF:M01882 Factor: IRF-2; motif: NNRAAAGTGAAASNNA 0.00252487555141237 258 96 8 0.0833333333333333 0.0310077519379845
TF TF:M11674_1 Factor: IRF-3; motif: GCNGTTTCCWGGAAACNGAAAC; match class: 1 0.00261484074496683 1663 62 16 0.258064516129032 0.00962116656644618
TF TF:M01260_1 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN; match class: 1 0.00272015161141684 657 51 9 0.176470588235294 0.0136986301369863
TF TF:M11678 Factor: IRF-7; motif: NNGAAAGTGAAANTR 0.00334194498305467 179 106 7 0.0660377358490566 0.0391061452513966
TF TF:M00225 Factor: STAT3; motif: NGNNATTTCCSGGAARTGNNN 0.00350224192938337 3188 43 18 0.418604651162791 0.00564617314930991
TF TF:M10079 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC 0.00496994513502805 2284 59 18 0.305084745762712 0.00788091068301226
TF TF:M07229 Factor: STAT3; motif: NTTCYKGGAAN 0.00522122687607332 3717 59 24 0.406779661016949 0.00645682001614205
TF TF:M01595_1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 1 0.00611611633391073 2700 43 16 0.372093023255814 0.00592592592592593
TF TF:M09664 Factor: STAT3; motif: NTTCCYGGAAN 0.00724242457551962 5587 55 29 0.527272727272727 0.00519062108466082
TF TF:M07229_1 Factor: STAT3; motif: NTTCYKGGAAN; match class: 1 0.00963839999605375 969 51 10 0.196078431372549 0.0103199174406605
TF TF:M00774_1 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN; match class: 1 0.00963839999605375 192 83 6 0.072289156626506 0.03125
TF TF:M11728 Factor: NF-1C; motif: NTTGGCNNNNTGCCARN 0.0107276036670422 2634 29 12 0.413793103448276 0.00455580865603645
TF TF:M00223 Factor: STAT; motif: TTCCCGKAA 0.0113130349731063 3501 43 18 0.418604651162791 0.0051413881748072
TF TF:M00208_1 Factor: NF-kappaB; motif: NGGGACTTTCCA; match class: 1 0.0125601658326163 604 19 5 0.263157894736842 0.00827814569536424
TF TF:M00205_1 Factor: GR; motif: GGTACAANNTGTYCTK; match class: 1 0.0125601658326163 1482 103 19 0.184466019417476 0.0128205128205128
TF TF:M00641 Factor: HSF; motif: TTCCMGARGYTTC 0.0125601658326163 3599 64 24 0.375 0.00666851903306474
TF TF:M11675 Factor: IRF-3; motif: KCNGTTTCSNSGAAACCGAAACN 0.0125601658326163 4655 60 27 0.45 0.00580021482277121
TF TF:M00447_1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 1 0.0126625676972318 854 71 11 0.154929577464789 0.0128805620608899
TF TF:M04018_1 Factor: IRF7; motif: NCGAAARYGAAANT; match class: 1 0.0132393930560058 24 100 3 0.03 0.125
TF TF:M00192_1 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN; match class: 1 0.0132393930560058 1974 28 10 0.357142857142857 0.00506585612968592
TF TF:M06622 Factor: ZNF681; motif: NKGGGAAAACSA 0.0195684230543994 86 77 4 0.051948051948052 0.0465116279069767
TF TF:M04745 Factor: CTCF; motif: CANNWRRTGGCAG 0.0198659994725098 8198 9 9 1 0.00109782873871676
TF TF:M11074 Factor: DEC1; motif: GTCACGTGAC 0.0198659994725098 4132 16 10 0.625 0.00242013552758954
TF TF:M08557 Factor: ER71:HOXA2; motif: RCCGGAAGNNNNNNNMATTA 0.0201026176737508 221 31 4 0.129032258064516 0.0180995475113122
TF TF:M01260 Factor: STAT1; motif: NNTTTCYNGGAARNNNNNNNNN 0.0201026176737508 2130 59 16 0.271186440677966 0.00751173708920188
TF TF:M00224_1 Factor: STAT1; motif: NNNSANTTCCGGGAANTGNSN; match class: 1 0.0201026176737508 2710 43 15 0.348837209302326 0.00553505535055351
TF TF:M09941_1 Factor: GR; motif: RGNACANMNTGTNCY; match class: 1 0.0210739257109393 2046 39 12 0.307692307692308 0.00586510263929619
TF TF:M03554 Factor: NF-1A; motif: NGCCARN 0.0211356768916981 4908 34 18 0.529411764705882 0.00366748166259169
TF TF:M09874 Factor: BCL-6; motif: NNCTTTCYAGGAA 0.0214981499491163 2807 42 15 0.357142857142857 0.00534378339864624
TF TF:M03557_1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 0.0214981499491163 1292 95 16 0.168421052631579 0.0123839009287926
TF TF:M07322_1 Factor: HSF4; motif: CTGCMRN; match class: 1 0.0225257490023368 11797 15 15 1 0.00127150970585742
TF TF:M00054_1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 1 0.0230326648675931 712 19 5 0.263157894736842 0.00702247191011236
TF TF:M01023 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM 0.0237513361495381 2721 35 13 0.371428571428571 0.0047776552737964
TF TF:M07353 Factor: E2A; motif: CAGNTGNN 0.0237513361495381 2645 16 8 0.5 0.00302457466918715
TF TF:M10081_1 Factor: STAT3; motif: NNYTTCCMRGAA; match class: 1 0.0237513361495381 1029 55 10 0.181818181818182 0.00971817298347911
TF TF:M09933_1 Factor: FOXP1; motif: TNTGTTTMY; match class: 1 0.0237513361495381 634 72 9 0.125 0.0141955835962145
TF TF:M07064 Factor: STAT1; motif: TTCNRGGAAN 0.0244052825151687 2606 55 17 0.309090909090909 0.00652340752110514
TF TF:M03966_1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 1 0.0245305619043523 1577 31 9 0.290322580645161 0.00570703868103995
TF TF:M00346 Factor: GATA-1; motif: NCWGATAACA 0.0245305619043523 4376 35 17 0.485714285714286 0.00388482632541133
TF TF:M07124 Factor: AML3; motif: KNKNTYTGTGGTTTK 0.0245305619043523 1440 122 20 0.163934426229508 0.0138888888888889
TF TF:M11819 Factor: T3R-beta; motif: RTGACCTYACRTGACCTYA 0.025586219767086 6924 10 9 0.9 0.0012998266897747
TF TF:M04168_1 Factor: CLOCK; motif: AACACGTGTN; match class: 1 0.0266011586247326 183 18 3 0.166666666666667 0.0163934426229508
TF TF:M01996 Factor: AR; motif: GNNCNNNNTGTTCTN 0.027085952511993 3085 78 24 0.307692307692308 0.00777957860615883
TF TF:M00175 Factor: AP-4; motif: VDCAGCTGNN 0.0276300351968025 2471 96 24 0.25 0.00971266693646297
TF TF:M10042_1 Factor: PR; motif: RGNACATTYTGTNCTN; match class: 1 0.0282879576112085 998 39 8 0.205128205128205 0.00801603206412826
TF TF:M08398_1 Factor: POU2F1:Elk-1; motif: ACCGGAWATGCAW; match class: 1 0.0283830860951235 1948 37 11 0.297297297297297 0.00564681724845996
TF TF:M12155_1 Factor: Sp2; motif: NTWAGTCCCGCCCMCTT; match class: 1 0.0284095678712452 1008 30 7 0.233333333333333 0.00694444444444444
TF TF:M03867_1 Factor: c-Myc; motif: CACGTGGC; match class: 1 0.0306834607839194 2694 13 7 0.538461538461538 0.00259836674090572
TF TF:M02084_1 Factor: AML1; motif: TGTGGT; match class: 1 0.0306834607839194 5429 8 7 0.875 0.00128937189169276
TF TF:M00271_1 Factor: AML1a; motif: TGTGGT; match class: 1 0.0306834607839194 5429 8 7 0.875 0.00128937189169276
TF TF:M00340_1 Factor: c-Ets; motif: KRCAGGAARTRNKT; match class: 1 0.0306834607839194 906 54 9 0.166666666666667 0.00993377483443709
TF TF:M09983 Factor: Max; motif: NNGCACGTGG 0.0306834607839194 116 30 3 0.1 0.0258620689655172
TF TF:M00751_1 Factor: AML1; motif: TGTGGT; match class: 1 0.0306834607839194 5429 8 7 0.875 0.00128937189169276
TF TF:M00380 Factor: Pax-4; motif: RAAAAWTANNNNNNNNNNNNNNNYCACNCC 0.0316111350983303 852 5 3 0.6 0.00352112676056338
TF TF:M04453_1 Factor: AR; motif: RGGWACAYNGTGTWCYN; match class: 1 0.0322615020411768 3794 108 35 0.324074074074074 0.00922509225092251
TF TF:M11073 Factor: DEC1; motif: GTCACGTGAC 0.033162107798559 6583 16 12 0.75 0.00182287710770166
TF TF:M03793_1 Factor: IRF-7; motif: AARGGAAANNGAA; match class: 1 0.0340240337685631 138 60 4 0.0666666666666667 0.0289855072463768
TF TF:M12286 Factor: ZNF647; motif: NYAGGCCYAC 0.0349999550682481 6231 25 16 0.64 0.00256780613063714
TF TF:M10025_1 Factor: p73; motif: NNRCAWGYCCARRCWTGYC; match class: 1 0.0351566496063265 1411 93 16 0.172043010752688 0.0113394755492558
TF TF:M04054_1 Factor: NF-kappaB; motif: AGGGGAWTCCCCT; match class: 1 0.035210908200112 1295 25 7 0.28 0.00540540540540541
TF TF:M09959_1 Factor: IRF-4; motif: NAANGRGGAASTGAAASN; match class: 1 0.0352659860870865 395 77 7 0.0909090909090909 0.0177215189873418
TF TF:M07054 Factor: P53; motif: NNNNNACAWGCCYNNN 0.0352659860870865 3074 22 10 0.454545454545455 0.00325309043591412
TF TF:M01066 Factor: Blimp-1; motif: NRGRAAGKGAAAGKRN 0.035339968214559 411 96 8 0.0833333333333333 0.0194647201946472
TF TF:M02265 Factor: NFATc2; motif: TTTTCCA 0.0356242665696193 7752 42 27 0.642857142857143 0.00348297213622291
TF TF:M11453 Factor: ELFR; motif: AAMCAGGAAGTR 0.0356242665696193 488 31 5 0.161290322580645 0.0102459016393443
TF TF:M03545_1 Factor: c-Rel; motif: NGGGAATYTCCN; match class: 1 0.0357327610491401 1011 105 14 0.133333333333333 0.0138476755687438
TF TF:M08253 Factor: ER71:FIGLA; motif: RSCGGAARCAGSTGNN 0.0357327610491401 204 19 3 0.157894736842105 0.0147058823529412
TF TF:M11363 Factor: c-MAF; motif: NTGCTGACNNWGCA 0.0357327610491401 422 21 4 0.19047619047619 0.00947867298578199
TF TF:M00638 Factor: HNF4alpha; motif: VTGAACTTTGMMB 0.0359474126592759 2814 118 30 0.254237288135593 0.0106609808102345
TF TF:M01279_1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 0.0376578977968051 101 86 4 0.0465116279069767 0.0396039603960396
TF TF:M10161_1 Factor: ZNF667; motif: GNGSCYTNMARAGCTCMNC; match class: 1 0.0379531445222351 394 102 8 0.0784313725490196 0.0203045685279188
TF TF:M00539_1 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1 0.0383139102405131 6676 24 16 0.666666666666667 0.00239664469742361
TF TF:M00539 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN 0.0383139102405131 6676 24 16 0.666666666666667 0.00239664469742361
TF TF:M09663_1 Factor: STAT1; motif: YCMTTTCCNGGAAAWCNCATNN; match class: 1 0.0387027505633383 554 42 6 0.142857142857143 0.0108303249097473
TF TF:M11458 Factor: nerf; motif: AANCMGGAAGTR 0.0387027505633383 505 31 5 0.161290322580645 0.0099009900990099
TF TF:M04168 Factor: CLOCK; motif: AACACGTGTN 0.0387027505633383 225 18 3 0.166666666666667 0.0133333333333333
TF TF:M00054 Factor: NF-kappaB; motif: GGGAMTTYCC 0.0388462477387836 2444 23 9 0.391304347826087 0.00368248772504092
TF TF:M04051 Factor: NFATc1; motif: NATGGAAANWNANTTTYCMN 0.0388462477387836 5610 10 8 0.8 0.00142602495543672
TF TF:M07375 Factor: BCL-6; motif: TTCCTAGAAA 0.0388462477387836 556 42 6 0.142857142857143 0.0107913669064748
TF TF:M00208 Factor: NF-kappaB; motif: NGGGACTTTCCA 0.0394171920244405 3757 115 36 0.31304347826087 0.00958211338834176
TF TF:M11266_1 Factor: c-Jun; motif: NATGACGTCAYN; match class: 1 0.0414559715843041 6308 118 54 0.457627118644068 0.00856055802155992
TF TF:M04052 Factor: NFATc1; motif: TTTCCAYWRTGGAAA 0.0420760626025826 6663 37 22 0.594594594594595 0.00330181599879934
TF TF:M09762_1 Factor: NF1B; motif: CYTGGCNYNCWGCCAN; match class: 1 0.0439791829302342 1514 23 7 0.304347826086957 0.00462351387054161
TF TF:M12207 Factor: GATA-4; motif: NNGATAASNN 0.045563945388132 2844 17 8 0.470588235294118 0.00281293952180028
TF TF:M11074_1 Factor: DEC1; motif: GTCACGTGAC; match class: 1 0.045563945388132 3890 16 9 0.5625 0.00231362467866324
TF TF:M09875 Factor: BHLHA15; motif: SNAGCAGCTGG 0.0467354560118542 1149 86 13 0.151162790697674 0.0113141862489121
TF TF:M03841 Factor: PEBP2beta; motif: TGTGGTY 0.0468875341455028 7720 7 7 1 0.000906735751295337
TF TF:M07223 Factor: Pax-5; motif: NNRNKCAGYSRAGCRTGAC 0.0468875341455028 5600 21 13 0.619047619047619 0.00232142857142857
TF TF:M04325 Factor: GSC2; motif: NNTAATCCNN 0.0470026459590977 3592 41 16 0.390243902439024 0.0044543429844098
WP WP:WP4197 The human immune response to tuberculosis 9.09749293650823e-12 23 62 9 0.145161290322581 0.391304347826087
WP WP:WP619 Type II interferon signaling (IFNG) 1.55726395794523e-08 37 19 6 0.315789473684211 0.162162162162162
WP WP:WP4880 Host-pathogen interaction of human corona viruses - Interferon induction 3.41403258122536e-08 33 113 9 0.079646017699115 0.272727272727273
WP WP:WP4868 Type I Interferon Induction and Signaling During SARS-CoV-2 Infection 2.13522282036968e-07 29 113 8 0.0707964601769911 0.275862068965517
WP WP:WP5039 SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response 0.00215411734454984 68 10 3 0.3 0.0441176470588235
WP WP:WP4341 Non-genomic actions of 1,25 dihydroxyvitamin D3 0.00564143080112892 70 65 5 0.0769230769230769 0.0714285714285714
WP WP:WP4217 Ebola Virus Pathway on Host 0.00564143080112892 130 19 4 0.210526315789474 0.0307692307692308
WP WP:WP4877 Host-pathogen interaction of human corona viruses - MAPK signaling 0.00564143080112892 36 71 4 0.0563380281690141 0.111111111111111
WP WP:WP4705 Pathways of nucleic acid metabolism and innate immune sensing 0.00966252672132955 16 83 3 0.036144578313253 0.1875
WP WP:WP4912 SARS coronavirus and innate immunity 0.0387638517170161 31 83 3 0.036144578313253 0.0967741935483871
WP WP:WP5038 SARS-CoV-2 mitochondrial interactions 0.039943000042053 32 83 3 0.036144578313253 0.09375

pP09 transcription factor target enrichment of top program genes

TF enrichment of pP09
TFs corrosponding to activation of pP09. (Left) pearson correlation of TF expression and gene expression program activatity in Plasma cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.