pTNI08 program activity among T/NK/ILC cells

Activation of pTNI08
pTNI08 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI08 by different cell subtypes
pTNI08 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI08 top program genes

Top genes of pTNI08 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI08 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI08
pTNI08 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002376 immune system process 1.24483193836639e-12 3278 102 55 0.53921568627451 0.0167785234899329
GO:BP GO:0001775 cell activation 5.56896396437502e-12 1495 131 42 0.320610687022901 0.0280936454849498
GO:BP GO:0045321 leukocyte activation 5.56896396437502e-12 1332 81 31 0.382716049382716 0.0232732732732733
GO:BP GO:0006955 immune response 6.50122784393252e-12 2311 131 52 0.396946564885496 0.022501081782778
GO:BP GO:0002263 cell activation involved in immune response 1.84386800824921e-11 721 131 29 0.221374045801527 0.0402219140083218
GO:BP GO:0002366 leukocyte activation involved in immune response 1.84386800824921e-11 717 131 29 0.221374045801527 0.0404463040446304
GO:BP GO:0002252 immune effector process 2.57480673494443e-11 1309 131 38 0.290076335877863 0.0290297937356761
GO:BP GO:0043299 leukocyte degranulation 3.8338958141883e-11 535 131 25 0.190839694656489 0.0467289719626168
GO:BP GO:0002275 myeloid cell activation involved in immune response 5.60679158364654e-11 547 131 25 0.190839694656489 0.0457038391224863
GO:BP GO:0002444 myeloid leukocyte mediated immunity 5.94021434347624e-11 551 131 25 0.190839694656489 0.0453720508166969
GO:BP GO:0002684 positive regulation of immune system process 1.96584299898304e-10 1065 29 16 0.551724137931034 0.0150234741784038
GO:BP GO:0002274 myeloid leukocyte activation 3.78636274182778e-10 667 140 27 0.192857142857143 0.04047976011994
GO:BP GO:0045055 regulated exocytosis 4.72591749167453e-10 785 131 28 0.213740458015267 0.0356687898089172
GO:BP GO:0002443 leukocyte mediated immunity 1.0597176237493e-09 877 131 29 0.221374045801527 0.0330672748004561
GO:BP GO:0006887 exocytosis 2.07259670778598e-09 904 131 29 0.221374045801527 0.0320796460176991
GO:BP GO:0050776 regulation of immune response 2.74341592660441e-09 996 22 13 0.590909090909091 0.0130522088353414
GO:BP GO:0016192 vesicle-mediated transport 4.48768508724222e-09 2180 131 45 0.343511450381679 0.0206422018348624
GO:BP GO:0002682 regulation of immune system process 4.91030717584248e-09 1617 29 17 0.586206896551724 0.0105132962275819
GO:BP GO:0046649 lymphocyte activation 2.2900737920305e-08 771 81 20 0.246913580246914 0.0259403372243839
GO:BP GO:0043312 neutrophil degranulation 4.97256434844912e-08 482 131 20 0.152671755725191 0.04149377593361
GO:BP GO:0002283 neutrophil activation involved in immune response 5.27965986536909e-08 485 131 20 0.152671755725191 0.0412371134020619
GO:BP GO:0002446 neutrophil mediated immunity 7.65144189986787e-08 497 131 20 0.152671755725191 0.0402414486921529
GO:BP GO:0042119 neutrophil activation 7.65144189986787e-08 498 131 20 0.152671755725191 0.0401606425702811
GO:BP GO:0036230 granulocyte activation 9.03159510710025e-08 504 131 20 0.152671755725191 0.0396825396825397
GO:BP GO:0043303 mast cell degranulation 9.81427467481524e-08 48 71 7 0.0985915492957746 0.145833333333333
GO:BP GO:0002448 mast cell mediated immunity 1.05690579306961e-07 49 71 7 0.0985915492957746 0.142857142857143
GO:BP GO:0002279 mast cell activation involved in immune response 1.05690579306961e-07 49 71 7 0.0985915492957746 0.142857142857143
GO:BP GO:0007166 cell surface receptor signaling pathway 1.65342692626996e-07 3210 24 18 0.75 0.00560747663551402
GO:BP GO:0006909 phagocytosis 3.10083166539001e-07 387 70 13 0.185714285714286 0.0335917312661499
GO:BP GO:0045576 mast cell activation 5.23098501164988e-07 62 71 7 0.0985915492957746 0.112903225806452
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 5.46210496389277e-07 2255 23 15 0.652173913043478 0.00665188470066519
GO:BP GO:0050778 positive regulation of immune response 6.72277571370869e-07 753 22 10 0.454545454545455 0.0132802124833997
GO:BP GO:0032940 secretion by cell 7.92237521156931e-07 1364 131 31 0.236641221374046 0.0227272727272727
GO:BP GO:0006952 defense response 7.92237521156931e-07 1818 140 38 0.271428571428571 0.0209020902090209
GO:BP GO:0043207 response to external biotic stimulus 8.93562486261007e-07 1594 23 13 0.565217391304348 0.0081555834378921
GO:BP GO:0051707 response to other organism 8.93562486261007e-07 1592 23 13 0.565217391304348 0.00816582914572864
GO:BP GO:0098542 defense response to other organism 1.05488484273258e-06 1218 102 25 0.245098039215686 0.0205254515599343
GO:BP GO:0009607 response to biotic stimulus 1.07783787199224e-06 1626 23 13 0.565217391304348 0.00799507995079951
GO:BP GO:0046903 secretion 1.6421266701782e-06 1501 131 32 0.244274809160305 0.0213191205862758
GO:BP GO:0140352 export from cell 1.6421266701782e-06 1418 131 31 0.236641221374046 0.0218617771509168
GO:BP GO:0032418 lysosome localization 1.6421266701782e-06 76 71 7 0.0985915492957746 0.0921052631578947
GO:BP GO:0051649 establishment of localization in cell 2.2151964908916e-06 2813 131 46 0.351145038167939 0.016352648418059
GO:BP GO:0050865 regulation of cell activation 2.8526002679502e-06 655 53 13 0.245283018867925 0.0198473282442748
GO:BP GO:0002757 immune response-activating signal transduction 2.8526002679502e-06 477 29 9 0.310344827586207 0.0188679245283019
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 2.8526002679502e-06 477 29 9 0.310344827586207 0.0188679245283019
GO:BP GO:0032103 positive regulation of response to external stimulus 3.17861900826739e-06 513 14 7 0.5 0.01364522417154
GO:BP GO:1903131 mononuclear cell differentiation 4.22067905373765e-06 430 81 13 0.160493827160494 0.0302325581395349
GO:BP GO:0045088 regulation of innate immune response 4.78145688233622e-06 309 60 10 0.166666666666667 0.0323624595469256
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 4.78145688233622e-06 512 29 9 0.310344827586207 0.017578125
GO:BP GO:0002764 immune response-regulating signaling pathway 4.92583097048232e-06 515 29 9 0.310344827586207 0.0174757281553398
GO:BP GO:0032101 regulation of response to external stimulus 5.74518563018243e-06 1051 21 10 0.476190476190476 0.00951474785918173
GO:BP GO:0031347 regulation of defense response 6.18172945426766e-06 704 17 8 0.470588235294118 0.0113636363636364
GO:BP GO:0002886 regulation of myeloid leukocyte mediated immunity 6.46518761824043e-06 54 127 7 0.0551181102362205 0.12962962962963
GO:BP GO:0002703 regulation of leukocyte mediated immunity 6.92982747346719e-06 205 71 9 0.126760563380282 0.0439024390243902
GO:BP GO:0045087 innate immune response 8.71597651346776e-06 998 102 21 0.205882352941176 0.0210420841683367
GO:BP GO:0002521 leukocyte differentiation 8.71597651346776e-06 550 81 14 0.172839506172839 0.0254545454545455
GO:BP GO:0071345 cellular response to cytokine stimulus 9.26167346683922e-06 1132 99 22 0.222222222222222 0.019434628975265
GO:BP GO:0002253 activation of immune response 9.61495618358784e-06 568 29 9 0.310344827586207 0.0158450704225352
GO:BP GO:0002699 positive regulation of immune effector process 9.61495618358784e-06 215 71 9 0.126760563380282 0.0418604651162791
GO:BP GO:0042127 regulation of cell population proliferation 9.76674485877874e-06 1774 99 28 0.282828282828283 0.0157835400225479
GO:BP GO:0002696 positive regulation of leukocyte activation 1.32460606037948e-05 412 52 10 0.192307692307692 0.0242718446601942
GO:BP GO:0051249 regulation of lymphocyte activation 1.38407957945193e-05 518 53 11 0.207547169811321 0.0212355212355212
GO:BP GO:0042113 B cell activation 1.38407957945193e-05 330 81 11 0.135802469135802 0.0333333333333333
GO:BP GO:0035556 intracellular signal transduction 1.44429719088383e-05 2772 142 46 0.323943661971831 0.0165945165945166
GO:BP GO:0007165 signal transduction 1.44839188001609e-05 6309 144 80 0.555555555555556 0.0126802979870027
GO:BP GO:0048583 regulation of response to stimulus 1.44839188001609e-05 4278 142 61 0.429577464788732 0.0142589995324918
GO:BP GO:0070664 negative regulation of leukocyte proliferation 1.48500273411827e-05 92 53 6 0.113207547169811 0.0652173913043478
GO:BP GO:0050867 positive regulation of cell activation 1.54815081633885e-05 424 52 10 0.192307692307692 0.0235849056603774
GO:BP GO:0038094 Fc-gamma receptor signaling pathway 1.7495937605709e-05 137 60 7 0.116666666666667 0.0510948905109489
GO:BP GO:0051250 negative regulation of lymphocyte activation 1.7495937605709e-05 156 53 7 0.132075471698113 0.0448717948717949
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 2.07375149579139e-05 141 60 7 0.116666666666667 0.049645390070922
GO:BP GO:0045089 positive regulation of innate immune response 2.11647909826674e-05 216 14 5 0.357142857142857 0.0231481481481481
GO:BP GO:0051641 cellular localization 2.24729083854525e-05 3541 141 53 0.375886524822695 0.0149675232985032
GO:BP GO:0034097 response to cytokine 2.80021430375945e-05 1226 99 22 0.222222222222222 0.0179445350734095
GO:BP GO:0043300 regulation of leukocyte degranulation 3.30413090734616e-05 45 127 6 0.047244094488189 0.133333333333333
GO:BP GO:0023052 signaling 3.63600959322444e-05 6810 144 83 0.576388888888889 0.0121879588839941
GO:BP GO:0002250 adaptive immune response 3.9258789241223e-05 689 22 8 0.363636363636364 0.011611030478955
GO:BP GO:0051251 positive regulation of lymphocyte activation 3.93135954902912e-05 365 52 9 0.173076923076923 0.0246575342465753
GO:BP GO:0002833 positive regulation of response to biotic stimulus 3.94571123623798e-05 250 14 5 0.357142857142857 0.02
GO:BP GO:0007154 cell communication 3.94571123623798e-05 6829 144 83 0.576388888888889 0.0121540489090643
GO:BP GO:0002831 regulation of response to biotic stimulus 4.31719492699622e-05 415 60 10 0.166666666666667 0.0240963855421687
GO:BP GO:0048534 hematopoietic or lymphoid organ development 4.42412733767576e-05 966 81 17 0.209876543209877 0.0175983436853002
GO:BP GO:0038093 Fc receptor signaling pathway 4.8738333470267e-05 238 60 8 0.133333333333333 0.0336134453781513
GO:BP GO:0002695 negative regulation of leukocyte activation 5.13116958256786e-05 188 53 7 0.132075471698113 0.0372340425531915
GO:BP GO:0002694 regulation of leukocyte activation 5.15740259626858e-05 610 53 11 0.207547169811321 0.0180327868852459
GO:BP GO:0110088 hippocampal neuron apoptotic process 5.55840705484926e-05 4 127 3 0.0236220472440945 0.75
GO:BP GO:0110089 regulation of hippocampal neuron apoptotic process 5.55840705484926e-05 4 127 3 0.0236220472440945 0.75
GO:BP GO:1903708 positive regulation of hemopoiesis 6.16856175187729e-05 157 126 9 0.0714285714285714 0.0573248407643312
GO:BP GO:1902107 positive regulation of leukocyte differentiation 6.16856175187729e-05 157 126 9 0.0714285714285714 0.0573248407643312
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 6.4722253643271e-05 760 128 19 0.1484375 0.025
GO:BP GO:0009605 response to external stimulus 6.51245839145964e-05 2944 23 14 0.608695652173913 0.0047554347826087
GO:BP GO:0043304 regulation of mast cell degranulation 7.15645292860827e-05 30 126 5 0.0396825396825397 0.166666666666667
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 7.15645292860827e-05 122 14 4 0.285714285714286 0.0327868852459016
GO:BP GO:0001816 cytokine production 7.15645292860827e-05 844 76 15 0.197368421052632 0.0177725118483412
GO:BP GO:0002520 immune system development 8.03898659056255e-05 1020 81 17 0.209876543209877 0.0166666666666667
GO:BP GO:0071310 cellular response to organic substance 8.06110975508862e-05 2776 99 34 0.343434343434343 0.0122478386167147
GO:BP GO:0033006 regulation of mast cell activation involved in immune response 8.13898756485484e-05 31 126 5 0.0396825396825397 0.161290322580645
GO:BP GO:0050866 negative regulation of cell activation 9.39426748410864e-05 211 53 7 0.132075471698113 0.033175355450237
GO:BP GO:0090322 regulation of superoxide metabolic process 9.77391888683208e-05 32 127 5 0.0393700787401575 0.15625
GO:BP GO:0030097 hemopoiesis 0.000102286964569561 928 81 16 0.197530864197531 0.0172413793103448
GO:BP GO:0050870 positive regulation of T cell activation 0.000102286964569561 219 52 7 0.134615384615385 0.0319634703196347
GO:BP GO:0002685 regulation of leukocyte migration 0.000104684494644166 211 102 9 0.0882352941176471 0.042654028436019
GO:BP GO:0008283 cell population proliferation 0.000109451564197379 2054 99 28 0.282828282828283 0.0136319376825706
GO:BP GO:0051656 establishment of organelle localization 0.000110786370644689 445 128 14 0.109375 0.0314606741573034
GO:BP GO:0097529 myeloid leukocyte migration 0.000112828449872521 221 126 10 0.0793650793650794 0.0452488687782805
GO:BP GO:0002697 regulation of immune effector process 0.000112828449872521 461 76 11 0.144736842105263 0.0238611713665944
GO:BP GO:0071675 regulation of mononuclear cell migration 0.000115444796507652 113 102 7 0.0686274509803922 0.0619469026548673
GO:BP GO:0042110 T cell activation 0.000119561904767561 489 102 13 0.127450980392157 0.0265848670756646
GO:BP GO:0048584 positive regulation of response to stimulus 0.000129170442449278 2344 22 12 0.545454545454545 0.00511945392491468
GO:BP GO:0030168 platelet activation 0.000138597048912812 160 140 9 0.0642857142857143 0.05625
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.000147242946801528 810 17 7 0.411764705882353 0.00864197530864197
GO:BP GO:0010543 regulation of platelet activation 0.000152315880105769 36 126 5 0.0396825396825397 0.138888888888889
GO:BP GO:0050672 negative regulation of lymphocyte proliferation 0.000153743515808504 85 53 5 0.0943396226415094 0.0588235294117647
GO:BP GO:0032945 negative regulation of mononuclear cell proliferation 0.000161457567898935 86 53 5 0.0943396226415094 0.0581395348837209
GO:BP GO:0031349 positive regulation of defense response 0.000166508436551939 362 14 5 0.357142857142857 0.0138121546961326
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.000167241547988212 241 52 7 0.134615384615385 0.029045643153527
GO:BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 0.000167241547988212 135 60 6 0.1 0.0444444444444444
GO:BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 0.000167241547988212 135 60 6 0.1 0.0444444444444444
GO:BP GO:0001817 regulation of cytokine production 0.000168343603259045 806 76 14 0.184210526315789 0.0173697270471464
GO:BP GO:0050863 regulation of T cell activation 0.000168343603259045 337 53 8 0.150943396226415 0.0237388724035608
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.000170631142875767 338 53 8 0.150943396226415 0.0236686390532544
GO:BP GO:0001912 positive regulation of leukocyte mediated cytotoxicity 0.000173030089815448 51 13 3 0.230769230769231 0.0588235294117647
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 0.000187384368298638 104 46 5 0.108695652173913 0.0480769230769231
GO:BP GO:0030098 lymphocyte differentiation 0.000191871123490026 376 81 10 0.123456790123457 0.0265957446808511
GO:BP GO:0018212 peptidyl-tyrosine modification 0.000191871123490026 388 135 13 0.0962962962962963 0.0335051546391753
GO:BP GO:0001819 positive regulation of cytokine production 0.000191871123490026 452 68 10 0.147058823529412 0.0221238938053097
GO:BP GO:0071346 cellular response to interferon-gamma 0.000204937948145434 175 74 7 0.0945945945945946 0.04
GO:BP GO:0070663 regulation of leukocyte proliferation 0.00022416221257378 251 53 7 0.132075471698113 0.0278884462151394
GO:BP GO:0006950 response to stress 0.00022416221257378 4170 82 37 0.451219512195122 0.00887290167865707
GO:BP GO:0032930 positive regulation of superoxide anion generation 0.00022512378160428 19 127 4 0.031496062992126 0.210526315789474
GO:BP GO:2000145 regulation of cell motility 0.00022512378160428 1061 113 20 0.176991150442478 0.0188501413760603
GO:BP GO:0010646 regulation of cell communication 0.000230122715735998 3543 142 50 0.352112676056338 0.0141123341800734
GO:BP GO:0048518 positive regulation of biological process 0.000239726758168309 6363 29 22 0.758620689655172 0.00345748860600346
GO:BP GO:0043549 regulation of kinase activity 0.000241586455449537 921 141 21 0.148936170212766 0.0228013029315961
GO:BP GO:0031343 positive regulation of cell killing 0.000242888655492157 59 13 3 0.230769230769231 0.0508474576271186
GO:BP GO:0038083 peptidyl-tyrosine autophosphorylation 0.000242888655492157 41 126 5 0.0396825396825397 0.121951219512195
GO:BP GO:0034341 response to interferon-gamma 0.000250269199190553 196 96 8 0.0833333333333333 0.0408163265306122
GO:BP GO:0050764 regulation of phagocytosis 0.000253669727591564 98 53 5 0.0943396226415094 0.0510204081632653
GO:BP GO:0033003 regulation of mast cell activation 0.000268307590470887 42 126 5 0.0396825396825397 0.119047619047619
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.000277053856271325 284 68 8 0.117647058823529 0.028169014084507
GO:BP GO:0060326 cell chemotaxis 0.000277847956572363 310 126 11 0.0873015873015873 0.0354838709677419
GO:BP GO:0023051 regulation of signaling 0.000283753668846892 3578 142 50 0.352112676056338 0.0139742873113471
GO:BP GO:0050896 response to stimulus 0.000284049240199116 9407 142 99 0.697183098591549 0.0105240778143935
GO:BP GO:0030335 positive regulation of cell migration 0.000292178048125202 567 113 14 0.123893805309735 0.0246913580246914
GO:BP GO:0071621 granulocyte chemotaxis 0.000300534518652237 126 21 4 0.19047619047619 0.0317460317460317
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.000300534518652237 375 53 8 0.150943396226415 0.0213333333333333
GO:BP GO:0002687 positive regulation of leukocyte migration 0.000300534518652237 137 102 7 0.0686274509803922 0.0510948905109489
GO:BP GO:0030334 regulation of cell migration 0.000302822492595574 999 113 19 0.168141592920354 0.019019019019019
GO:BP GO:0032928 regulation of superoxide anion generation 0.000302822492595574 21 127 4 0.031496062992126 0.19047619047619
GO:BP GO:0040012 regulation of locomotion 0.000348432536401416 1104 113 20 0.176991150442478 0.0181159420289855
GO:BP GO:0080134 regulation of response to stress 0.000361618660102329 1443 21 9 0.428571428571429 0.00623700623700624
GO:BP GO:1902105 regulation of leukocyte differentiation 0.000387783529567753 288 71 8 0.112676056338028 0.0277777777777778
GO:BP GO:0045859 regulation of protein kinase activity 0.00039051459685848 809 141 19 0.134751773049645 0.0234857849196539
GO:BP GO:0009611 response to wounding 0.000414568582223638 674 126 16 0.126984126984127 0.0237388724035608
GO:BP GO:0001910 regulation of leukocyte mediated cytotoxicity 0.000417962434383495 74 13 3 0.230769230769231 0.0405405405405405
GO:BP GO:2000147 positive regulation of cell motility 0.000424826800931604 591 113 14 0.123893805309735 0.0236886632825719
GO:BP GO:0030889 negative regulation of B cell proliferation 0.000424826800931604 18 53 3 0.0566037735849057 0.166666666666667
GO:BP GO:0051640 organelle localization 0.000442407557500378 668 128 16 0.125 0.0239520958083832
GO:BP GO:0042060 wound healing 0.000508804302948818 549 140 15 0.107142857142857 0.0273224043715847
GO:BP GO:0051272 positive regulation of cellular component movement 0.000515530605033912 604 113 14 0.123893805309735 0.0231788079470199
GO:BP GO:0051270 regulation of cellular component movement 0.000515530605033912 1141 113 20 0.176991150442478 0.0175284837861525
GO:BP GO:0040017 positive regulation of locomotion 0.000531444988951097 606 113 14 0.123893805309735 0.0231023102310231
GO:BP GO:0097530 granulocyte migration 0.000534336358226265 151 21 4 0.19047619047619 0.0264900662251656
GO:BP GO:0002683 negative regulation of immune system process 0.000589428241068432 420 53 8 0.150943396226415 0.019047619047619
GO:BP GO:0071385 cellular response to glucocorticoid stimulus 0.000589428241068432 57 19 3 0.157894736842105 0.0526315789473684
GO:BP GO:0070661 leukocyte proliferation 0.000608246043712855 325 21 5 0.238095238095238 0.0153846153846154
GO:BP GO:0006468 protein phosphorylation 0.000608246043712855 1668 141 29 0.205673758865248 0.0173860911270983
GO:BP GO:0001932 regulation of protein phosphorylation 0.000619683981522428 1240 141 24 0.170212765957447 0.0193548387096774
GO:BP GO:0010033 response to organic substance 0.000624385991969987 3412 99 36 0.363636363636364 0.0105509964830012
GO:BP GO:0030155 regulation of cell adhesion 0.000632103691188161 748 71 12 0.169014084507042 0.0160427807486631
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.000644085746133567 385 135 12 0.0888888888888889 0.0311688311688312
GO:BP GO:1902531 regulation of intracellular signal transduction 0.000644085746133567 1842 142 31 0.21830985915493 0.0168295331161781
GO:BP GO:0014003 oligodendrocyte development 0.000652437179499016 47 70 4 0.0571428571428571 0.0851063829787234
GO:BP GO:0071677 positive regulation of mononuclear cell migration 0.000653421067292754 65 102 5 0.0490196078431373 0.0769230769230769
GO:BP GO:0002223 stimulatory C-type lectin receptor signaling pathway 0.000689932215472183 112 60 5 0.0833333333333333 0.0446428571428571
GO:BP GO:0051716 cellular response to stimulus 0.000691009450614959 7781 142 85 0.598591549295775 0.010924045752474
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.000691009450614959 1455 71 17 0.23943661971831 0.0116838487972509
GO:BP GO:0031341 regulation of cell killing 0.000712179053675324 93 13 3 0.230769230769231 0.032258064516129
GO:BP GO:0033674 positive regulation of kinase activity 0.000714958049760165 608 102 13 0.127450980392157 0.0213815789473684
GO:BP GO:0051384 response to glucocorticoid 0.000723654705708141 146 47 5 0.106382978723404 0.0342465753424658
GO:BP GO:0071384 cellular response to corticosteroid stimulus 0.000724712383441578 63 19 3 0.157894736842105 0.0476190476190476
GO:BP GO:0030593 neutrophil chemotaxis 0.000730632027475484 103 12 3 0.25 0.029126213592233
GO:BP GO:0030183 B cell differentiation 0.000739810029819445 140 81 6 0.0740740740740741 0.0428571428571429
GO:BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 0.000739810029819445 115 60 5 0.0833333333333333 0.0434782608695652
GO:BP GO:0042325 regulation of phosphorylation 0.000739810029819445 1431 141 26 0.184397163120567 0.0181691125087351
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0007587662803495 445 68 9 0.132352941176471 0.0202247191011236
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.0007587662803495 1001 102 17 0.166666666666667 0.016983016983017
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.0007587662803495 1001 102 17 0.166666666666667 0.016983016983017
GO:BP GO:0045582 positive regulation of T cell differentiation 0.000760929805183691 91 126 6 0.0476190476190476 0.0659340659340659
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.00079074521686312 536 71 10 0.140845070422535 0.0186567164179104
GO:BP GO:0060602 branch elongation of an epithelium 0.000881305598552733 19 69 3 0.0434782608695652 0.157894736842105
GO:BP GO:0051338 regulation of transferase activity 0.000908548930263886 1035 141 21 0.148936170212766 0.0202898550724638
GO:BP GO:0070887 cellular response to chemical stimulus 0.000954782988012041 3393 102 36 0.352941176470588 0.0106100795755968
GO:BP GO:0051674 localization of cell 0.000954782988012041 1828 127 28 0.220472440944882 0.0153172866520788
GO:BP GO:0050900 leukocyte migration 0.000954782988012041 511 25 6 0.24 0.0117416829745597
GO:BP GO:0048870 cell motility 0.000954782988012041 1828 127 28 0.220472440944882 0.0153172866520788
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.000954782988012041 107 13 3 0.230769230769231 0.0280373831775701
GO:BP GO:0043550 regulation of lipid kinase activity 0.000956915975768669 70 54 4 0.0740740740740741 0.0571428571428571
GO:BP GO:0009966 regulation of signal transduction 0.000956915975768669 3165 142 44 0.309859154929577 0.0139020537124803
GO:BP GO:0042327 positive regulation of phosphorylation 0.000993033020177193 927 102 16 0.156862745098039 0.017259978425027
GO:BP GO:0019220 regulation of phosphate metabolic process 0.00100039336448897 1645 141 28 0.198581560283688 0.0170212765957447
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.00100039336448897 1645 141 28 0.198581560283688 0.0170212765957447
GO:BP GO:0071674 mononuclear cell migration 0.00104107470968077 191 21 4 0.19047619047619 0.0209424083769634
GO:BP GO:0002708 positive regulation of lymphocyte mediated immunity 0.0010584750076379 104 14 3 0.214285714285714 0.0288461538461538
GO:BP GO:0016477 cell migration 0.00108070698095681 1649 127 26 0.204724409448819 0.015767131594906
GO:BP GO:1990266 neutrophil migration 0.00108070698095681 124 12 3 0.25 0.0241935483870968
GO:BP GO:0031960 response to corticosteroid 0.00108523367012809 165 47 5 0.106382978723404 0.0303030303030303
GO:BP GO:0001934 positive regulation of protein phosphorylation 0.00113733105445002 840 102 15 0.147058823529412 0.0178571428571429
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.00114183867423301 1103 97 17 0.175257731958763 0.0154125113327289
GO:BP GO:1902563 regulation of neutrophil activation 0.00114183867423301 12 127 3 0.0236220472440945 0.25
GO:BP GO:0048385 regulation of retinoic acid receptor signaling pathway 0.00115074322248422 17 88 3 0.0340909090909091 0.176470588235294
GO:BP GO:0038127 ERBB signaling pathway 0.00122090250420168 145 128 7 0.0546875 0.0482758620689655
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.00122377671685899 3274 127 41 0.322834645669291 0.0125229077580941
GO:BP GO:0007596 blood coagulation 0.0012869778843741 347 140 11 0.0785714285714286 0.031700288184438
GO:BP GO:0044093 positive regulation of molecular function 0.00129222410587832 1771 127 27 0.21259842519685 0.0152456239412761
GO:BP GO:0050853 B cell receptor signaling pathway 0.00130577157478162 135 60 5 0.0833333333333333 0.037037037037037
GO:BP GO:0007599 hemostasis 0.00139437393163126 351 140 11 0.0785714285714286 0.0313390313390313
GO:BP GO:0045619 regulation of lymphocyte differentiation 0.00139437393163126 180 46 5 0.108695652173913 0.0277777777777778
GO:BP GO:0048015 phosphatidylinositol-mediated signaling 0.00139651668479143 197 97 7 0.0721649484536082 0.0355329949238579
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00141043402072819 323 60 7 0.116666666666667 0.021671826625387
GO:BP GO:0050777 negative regulation of immune response 0.00142767775138865 157 53 5 0.0943396226415094 0.0318471337579618
GO:BP GO:0050817 coagulation 0.00147203841470227 354 140 11 0.0785714285714286 0.0310734463276836
GO:BP GO:0042554 superoxide anion generation 0.00152721465641722 35 127 4 0.031496062992126 0.114285714285714
GO:BP GO:0048017 inositol lipid-mediated signaling 0.00153751013681266 201 97 7 0.0721649484536082 0.0348258706467662
GO:BP GO:0048145 regulation of fibroblast proliferation 0.00153940451386065 87 97 5 0.0515463917525773 0.0574712643678161
GO:BP GO:0006801 superoxide metabolic process 0.00157496976030827 67 127 5 0.0393700787401575 0.0746268656716418
GO:BP GO:2000379 positive regulation of reactive oxygen species metabolic process 0.00157496976030827 107 127 6 0.047244094488189 0.0560747663551402
GO:BP GO:0048513 animal organ development 0.00158626212043899 3672 127 44 0.346456692913386 0.0119825708061002
GO:BP GO:0048144 fibroblast proliferation 0.00159895579692225 88 97 5 0.0515463917525773 0.0568181818181818
GO:BP GO:0014065 phosphatidylinositol 3-kinase signaling 0.00168792080930296 161 54 5 0.0925925925925926 0.031055900621118
GO:BP GO:0050920 regulation of chemotaxis 0.00173270228587807 226 21 4 0.19047619047619 0.0176991150442478
GO:BP GO:0030595 leukocyte chemotaxis 0.00175540396310954 227 21 4 0.19047619047619 0.0176211453744493
GO:BP GO:0002449 lymphocyte mediated immunity 0.00176428063522519 354 14 4 0.285714285714286 0.0112994350282486
GO:BP GO:0043085 positive regulation of catalytic activity 0.00176428063522519 1418 127 23 0.181102362204724 0.0162200282087447
GO:BP GO:0034616 response to laminar fluid shear stress 0.00177338332521128 16 113 3 0.0265486725663717 0.1875
GO:BP GO:1900272 negative regulation of long-term synaptic potentiation 0.00177338332521128 13 141 3 0.0212765957446809 0.230769230769231
GO:BP GO:0051234 establishment of localization 0.00180527799345415 5372 73 37 0.506849315068493 0.00688756515264334
GO:BP GO:0051347 positive regulation of transferase activity 0.00181384571777854 689 102 13 0.127450980392157 0.0188679245283019
GO:BP GO:0040011 locomotion 0.00184317976445104 2028 127 29 0.228346456692913 0.0142998027613412
GO:BP GO:0050869 negative regulation of B cell activation 0.00184317976445104 34 53 3 0.0566037735849057 0.0882352941176471
GO:BP GO:0065009 regulation of molecular function 0.00184718794198666 3221 136 42 0.308823529411765 0.0130394287488358
GO:BP GO:0032870 cellular response to hormone stimulus 0.00189529385533666 645 95 12 0.126315789473684 0.0186046511627907
GO:BP GO:0060341 regulation of cellular localization 0.00191630029502765 851 73 12 0.164383561643836 0.0141010575793184
GO:BP GO:0045579 positive regulation of B cell differentiation 0.00191630029502765 15 126 3 0.0238095238095238 0.2
GO:BP GO:0061180 mammary gland epithelium development 0.00195496919341195 69 27 3 0.111111111111111 0.0434782608695652
GO:BP GO:0046635 positive regulation of alpha-beta T cell activation 0.00198294424911527 67 28 3 0.107142857142857 0.0447761194029851
GO:BP GO:0002690 positive regulation of leukocyte chemotaxis 0.00216282941932529 93 21 3 0.142857142857143 0.032258064516129
GO:BP GO:0070849 response to epidermal growth factor 0.00225691213924171 49 40 3 0.075 0.0612244897959184
GO:BP GO:0006810 transport 0.00225818204051118 5224 73 36 0.493150684931507 0.00689127105666156
GO:BP GO:0007584 response to nutrient 0.00230429188943675 182 82 6 0.0731707317073171 0.032967032967033
GO:BP GO:0008285 negative regulation of cell population proliferation 0.00237970984835477 790 69 11 0.159420289855072 0.0139240506329114
GO:BP GO:0009893 positive regulation of metabolic process 0.00239083707076982 3783 108 39 0.361111111111111 0.0103092783505155
GO:BP GO:0009967 positive regulation of signal transduction 0.00239999193599354 1598 139 26 0.18705035971223 0.016270337922403
GO:BP GO:0016310 phosphorylation 0.00239999193599354 2138 135 31 0.22962962962963 0.0144995322731525
GO:BP GO:0042326 negative regulation of phosphorylation 0.00241015609553074 420 69 8 0.115942028985507 0.019047619047619
GO:BP GO:0002715 regulation of natural killer cell mediated immunity 0.00241015609553074 45 45 3 0.0666666666666667 0.0666666666666667
GO:BP GO:0002706 regulation of lymphocyte mediated immunity 0.00244056069038377 151 14 3 0.214285714285714 0.0198675496688742
GO:BP GO:0048522 positive regulation of cellular process 0.00244056069038377 5757 29 19 0.655172413793103 0.0033003300330033
GO:BP GO:1903706 regulation of hemopoiesis 0.00248287026737108 424 52 7 0.134615384615385 0.0165094339622642
GO:BP GO:0003401 axis elongation 0.00250016423522141 30 69 3 0.0434782608695652 0.1
GO:BP GO:0006968 cellular defense response 0.00250016423522141 53 99 4 0.0404040404040404 0.0754716981132075
GO:BP GO:0045860 positive regulation of protein kinase activity 0.00258391798153133 534 102 11 0.107843137254902 0.0205992509363296
GO:BP GO:0002313 mature B cell differentiation involved in immune response 0.00258391798153133 26 81 3 0.037037037037037 0.115384615384615
GO:BP GO:0045785 positive regulation of cell adhesion 0.00272867934939848 437 68 8 0.117647058823529 0.0183066361556064
GO:BP GO:0010647 positive regulation of cell communication 0.00272867934939848 1777 141 28 0.198581560283688 0.0157568936409679
GO:BP GO:0046634 regulation of alpha-beta T cell activation 0.00272867934939848 102 53 4 0.0754716981132075 0.0392156862745098
GO:BP GO:0007229 integrin-mediated signaling pathway 0.00272867934939848 111 140 6 0.0428571428571429 0.0540540540540541
GO:BP GO:0038095 Fc-epsilon receptor signaling pathway 0.00275505145179142 167 60 5 0.0833333333333333 0.029940119760479
GO:BP GO:0046636 negative regulation of alpha-beta T cell activation 0.00281182108616526 41 53 3 0.0566037735849057 0.0731707317073171
GO:BP GO:0023056 positive regulation of signaling 0.00281182108616526 1782 141 28 0.198581560283688 0.015712682379349
GO:BP GO:0001906 cell killing 0.00283149439504478 175 13 3 0.230769230769231 0.0171428571428571
GO:BP GO:0043407 negative regulation of MAP kinase activity 0.00292113021305594 80 69 4 0.0579710144927536 0.05
GO:BP GO:0032879 regulation of localization 0.0029316311683341 2872 141 39 0.276595744680851 0.0135793871866295
GO:BP GO:0019722 calcium-mediated signaling 0.0029558089272957 211 141 8 0.0567375886524823 0.037914691943128
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.00296475752235762 329 69 7 0.101449275362319 0.0212765957446809
GO:BP GO:0050864 regulation of B cell activation 0.00297534951780078 194 53 5 0.0943396226415094 0.0257731958762887
GO:BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 0.00301436552112778 81 69 4 0.0579710144927536 0.0493827160493827
GO:BP GO:0019932 second-messenger-mediated signaling 0.00303177669157169 327 142 10 0.0704225352112676 0.0305810397553517
GO:BP GO:0018146 keratan sulfate biosynthetic process 0.00303177669157169 28 81 3 0.037037037037037 0.107142857142857
GO:BP GO:0071222 cellular response to lipopolysaccharide 0.00306940465708875 200 52 5 0.0961538461538462 0.025
GO:BP GO:0050868 negative regulation of T cell activation 0.0031439090836356 123 19 3 0.157894736842105 0.024390243902439
GO:BP GO:0071375 cellular response to peptide hormone stimulus 0.0031597553318285 340 113 9 0.079646017699115 0.0264705882352941
GO:BP GO:0030278 regulation of ossification 0.0033993027035926 115 51 4 0.0784313725490196 0.0347826086956522
GO:BP GO:0009725 response to hormone 0.0033993027035926 921 95 14 0.147368421052632 0.0152008686210641
GO:BP GO:0071396 cellular response to lipid 0.00349073564859842 578 99 11 0.111111111111111 0.0190311418685121
GO:BP GO:0000165 MAPK cascade 0.00362010904628885 935 53 10 0.188679245283019 0.0106951871657754
GO:BP GO:0043200 response to amino acid 0.00362010904628885 115 52 4 0.0769230769230769 0.0347826086956522
GO:BP GO:0012501 programmed cell death 0.00373017949255882 2143 127 29 0.228346456692913 0.0135324311712552
GO:BP GO:0002688 regulation of leukocyte chemotaxis 0.00375849938782698 120 21 3 0.142857142857143 0.025
GO:BP GO:0097028 dendritic cell differentiation 0.00381941443473269 48 52 3 0.0576923076923077 0.0625
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.00390681001260278 1037 139 19 0.136690647482014 0.0183220829315333
GO:BP GO:0071219 cellular response to molecule of bacterial origin 0.00390681001260278 214 52 5 0.0961538461538462 0.0233644859813084
GO:BP GO:1903829 positive regulation of cellular protein localization 0.0039298862080654 303 21 4 0.19047619047619 0.0132013201320132
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.00405534459922511 306 21 4 0.19047619047619 0.0130718954248366
GO:BP GO:0002335 mature B cell differentiation 0.00411954213841847 32 81 3 0.037037037037037 0.09375
GO:BP GO:0050790 regulation of catalytic activity 0.00426376030239502 2545 135 34 0.251851851851852 0.0133595284872299
GO:BP GO:0008219 cell death 0.00429867826472774 2292 82 22 0.268292682926829 0.00959860383944154
GO:BP GO:0008284 positive regulation of cell population proliferation 0.00432523570783937 982 52 10 0.192307692307692 0.010183299389002
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.00434951707342989 142 19 3 0.157894736842105 0.0211267605633803
GO:BP GO:0043434 response to peptide hormone 0.00436895613750812 462 54 7 0.12962962962963 0.0151515151515152
GO:BP GO:0048585 negative regulation of response to stimulus 0.00436895613750812 1733 54 14 0.259259259259259 0.00807847663012118
GO:BP GO:0042339 keratan sulfate metabolic process 0.00440078603084281 33 81 3 0.037037037037037 0.0909090909090909
GO:BP GO:0030879 mammary gland development 0.00445906017007107 140 46 4 0.0869565217391304 0.0285714285714286
GO:BP GO:0010628 positive regulation of gene expression 0.00452756907133478 1160 70 13 0.185714285714286 0.0112068965517241
GO:BP GO:0042058 regulation of epidermal growth factor receptor signaling pathway 0.00452916188242807 90 128 5 0.0390625 0.0555555555555556
GO:BP GO:0002704 negative regulation of leukocyte mediated immunity 0.00454870940357916 51 53 3 0.0566037735849057 0.0588235294117647
GO:BP GO:0033993 response to lipid 0.00464010843776107 918 99 14 0.141414141414141 0.0152505446623094
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 0.00468088565409618 88 74 4 0.0540540540540541 0.0454545454545455
GO:BP GO:0030217 T cell differentiation 0.00473864463784482 260 126 8 0.0634920634920635 0.0307692307692308
GO:BP GO:0031399 regulation of protein modification process 0.00473864463784482 1671 141 26 0.184397163120567 0.0155595451825254
GO:BP GO:0001503 ossification 0.00474779221874759 417 29 5 0.172413793103448 0.0119904076738609
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00480397531461446 363 19 4 0.210526315789474 0.0110192837465565
GO:BP GO:0034612 response to tumor necrosis factor 0.00506779848010634 331 21 4 0.19047619047619 0.0120845921450151
GO:BP GO:0019216 regulation of lipid metabolic process 0.00509265420692299 419 100 9 0.09 0.0214797136038186
GO:BP GO:0042306 regulation of protein import into nucleus 0.00509265420692299 62 46 3 0.0652173913043478 0.0483870967741935
GO:BP GO:0031668 cellular response to extracellular stimulus 0.00509265420692299 248 134 8 0.0597014925373134 0.032258064516129
GO:BP GO:0009719 response to endogenous stimulus 0.00509265420692299 1683 126 24 0.19047619047619 0.0142602495543672
GO:BP GO:0098609 cell-cell adhesion 0.00509265420692299 894 127 16 0.125984251968504 0.0178970917225951
GO:BP GO:1903305 regulation of regulated secretory pathway 0.00517212187840323 144 127 6 0.047244094488189 0.0416666666666667
GO:BP GO:0001933 negative regulation of protein phosphorylation 0.00517212187840323 373 69 7 0.101449275362319 0.0187667560321716
GO:BP GO:0006928 movement of cell or subcellular component 0.00517691042177563 2311 127 30 0.236220472440945 0.0129813933362181
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.00520172561469559 503 102 10 0.0980392156862745 0.0198807157057654
GO:BP GO:0030099 myeloid cell differentiation 0.00526031233622345 428 79 8 0.10126582278481 0.0186915887850467
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.00528563704278294 230 53 5 0.0943396226415094 0.0217391304347826
GO:BP GO:0050921 positive regulation of chemotaxis 0.00529198402372738 141 21 3 0.142857142857143 0.0212765957446809
GO:BP GO:0050852 T cell receptor signaling pathway 0.00530752109555766 203 60 5 0.0833333333333333 0.0246305418719212
GO:BP GO:0002228 natural killer cell mediated immunity 0.00533867196211051 65 45 3 0.0666666666666667 0.0461538461538462
GO:BP GO:1901185 negative regulation of ERBB signaling pathway 0.00540775298611678 54 128 4 0.03125 0.0740740740740741
GO:BP GO:2000377 regulation of reactive oxygen species metabolic process 0.00540775298611678 203 127 7 0.0551181102362205 0.0344827586206897
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.00540775298611678 232 53 5 0.0943396226415094 0.021551724137931
GO:BP GO:0001818 negative regulation of cytokine production 0.00544463532419412 381 19 4 0.210526315789474 0.010498687664042
GO:BP GO:0046631 alpha-beta T cell activation 0.00544463532419412 155 79 5 0.0632911392405063 0.032258064516129
GO:BP GO:0045580 regulation of T cell differentiation 0.00548970089576826 152 46 4 0.0869565217391304 0.0263157894736842
GO:BP GO:0071216 cellular response to biotic stimulus 0.00548970089576826 238 52 5 0.0961538461538462 0.0210084033613445
GO:BP GO:0048384 retinoic acid receptor signaling pathway 0.00548970089576826 34 88 3 0.0340909090909091 0.0882352941176471
GO:BP GO:0033273 response to vitamin 0.00548970089576826 98 71 4 0.0563380281690141 0.0408163265306122
GO:BP GO:1904589 regulation of protein import 0.00549858926639937 65 46 3 0.0652173913043478 0.0461538461538462
GO:BP GO:0072593 reactive oxygen species metabolic process 0.00549858926639937 290 11 3 0.272727272727273 0.0103448275862069
GO:BP GO:0051897 positive regulation of protein kinase B signaling 0.00549858926639937 184 102 6 0.0588235294117647 0.0326086956521739
GO:BP GO:0001101 response to acid chemical 0.00549858926639937 135 52 4 0.0769230769230769 0.0296296296296296
GO:BP GO:0043551 regulation of phosphatidylinositol 3-kinase activity 0.00554512671413468 58 52 3 0.0576923076923077 0.0517241379310345
GO:BP GO:1901184 regulation of ERBB signaling pathway 0.00557947246843309 97 128 5 0.0390625 0.0515463917525773
GO:BP GO:0071276 cellular response to cadmium ion 0.00557947246843309 37 82 3 0.0365853658536585 0.0810810810810811
GO:BP GO:0033673 negative regulation of kinase activity 0.00557947246843309 275 69 6 0.0869565217391304 0.0218181818181818
GO:BP GO:0006935 chemotaxis 0.00558967126398227 653 126 13 0.103174603174603 0.0199081163859112
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.00561416166940592 184 17 3 0.176470588235294 0.016304347826087
GO:BP GO:0071495 cellular response to endogenous stimulus 0.00564210206823469 1422 99 18 0.181818181818182 0.0126582278481013
GO:BP GO:0071496 cellular response to external stimulus 0.0056480749603148 322 82 7 0.0853658536585366 0.0217391304347826
GO:BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 0.00570990234122615 133 54 4 0.0740740740740741 0.0300751879699248
GO:BP GO:0048709 oligodendrocyte differentiation 0.00570990234122615 102 70 4 0.0571428571428571 0.0392156862745098
GO:BP GO:0042330 taxis 0.00570990234122615 656 126 13 0.103174603174603 0.0198170731707317
GO:BP GO:0050878 regulation of body fluid levels 0.00570990234122615 514 140 12 0.0857142857142857 0.0233463035019455
GO:BP GO:0031401 positive regulation of protein modification process 0.00575058268341054 1074 141 19 0.134751773049645 0.0176908752327747
GO:BP GO:0031532 actin cytoskeleton reorganization 0.00576000473251207 106 119 5 0.0420168067226891 0.0471698113207547
GO:BP GO:0043302 positive regulation of leukocyte degranulation 0.00591611876427432 25 127 3 0.0236220472440945 0.12
GO:BP GO:0009617 response to bacterium 0.00603506745546382 743 60 9 0.15 0.0121130551816958
GO:BP GO:0051209 release of sequestered calcium ion into cytosol 0.00619280291104632 123 60 4 0.0666666666666667 0.032520325203252
GO:BP GO:0040007 growth 0.00619394155187112 967 47 9 0.191489361702128 0.0093071354705274
GO:BP GO:0045936 negative regulation of phosphate metabolic process 0.00633818908563345 543 135 12 0.0888888888888889 0.0220994475138122
GO:BP GO:0051283 negative regulation of sequestering of calcium ion 0.00633818908563345 124 60 4 0.0666666666666667 0.032258064516129
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00633818908563345 3483 108 35 0.324074074074074 0.0100488084984209
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.00634361498742997 197 17 3 0.176470588235294 0.0152284263959391
GO:BP GO:0018193 peptidyl-amino acid modification 0.00634361498742997 1303 29 8 0.275862068965517 0.00613967766692249
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 0.00634361498742997 544 135 12 0.0888888888888889 0.0220588235294118
GO:BP GO:0043409 negative regulation of MAPK cascade 0.0064200235554217 190 69 5 0.072463768115942 0.0263157894736842
GO:BP GO:0051282 regulation of sequestering of calcium ion 0.00653367964865044 126 60 4 0.0666666666666667 0.0317460317460317
GO:BP GO:0010799 regulation of peptidyl-threonine phosphorylation 0.00655075493781817 48 69 3 0.0434782608695652 0.0625
GO:BP GO:0007155 cell adhesion 0.00662162948987149 1492 129 22 0.170542635658915 0.014745308310992
GO:BP GO:0030888 regulation of B cell proliferation 0.00668643902058937 63 53 3 0.0566037735849057 0.0476190476190476
GO:BP GO:0032496 response to lipopolysaccharide 0.00693799859288026 338 60 6 0.1 0.0177514792899408
GO:BP GO:0022610 biological adhesion 0.00695057298047197 1499 129 22 0.170542635658915 0.0146764509673115
GO:BP GO:0051208 sequestering of calcium ion 0.00718086657103606 130 60 4 0.0666666666666667 0.0307692307692308
GO:BP GO:0032868 response to insulin 0.00728871641969965 295 95 7 0.0736842105263158 0.023728813559322
GO:BP GO:1990830 cellular response to leukemia inhibitory factor 0.00732273656442416 89 88 4 0.0454545454545455 0.0449438202247191
GO:BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 0.00733275279949225 269 135 8 0.0592592592592593 0.0297397769516729
GO:BP GO:1990823 response to leukemia inhibitory factor 0.00756892890923806 90 88 4 0.0454545454545455 0.0444444444444444
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.00756892890923806 309 12 3 0.25 0.00970873786407767
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.00756892890923806 1227 99 16 0.161616161616162 0.013039934800326
GO:BP GO:0051247 positive regulation of protein metabolic process 0.00761643005571153 1564 141 24 0.170212765957447 0.0153452685421995
GO:BP GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation 0.00762286478220643 59 135 4 0.0296296296296296 0.0677966101694915
GO:BP GO:1901700 response to oxygen-containing compound 0.00794220074384645 1739 99 20 0.202020202020202 0.0115008625646924
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.00795071043721187 194 19 3 0.157894736842105 0.0154639175257732
GO:BP GO:1901653 cellular response to peptide 0.00795779248422037 408 113 9 0.079646017699115 0.0220588235294118
GO:BP GO:0048856 anatomical structure development 0.00799165480634631 6106 127 60 0.47244094488189 0.00982640026203734
GO:BP GO:0042063 gliogenesis 0.0079944333451761 308 27 4 0.148148148148148 0.012987012987013
GO:BP GO:0045577 regulation of B cell differentiation 0.0079944333451761 29 126 3 0.0238095238095238 0.103448275862069
GO:BP GO:0031099 regeneration 0.00813736410090462 206 40 4 0.1 0.0194174757281553
GO:BP GO:0062207 regulation of pattern recognition receptor signaling pathway 0.00830896501242248 108 76 4 0.0526315789473684 0.037037037037037
GO:BP GO:0051348 negative regulation of transferase activity 0.00872993858901343 310 69 6 0.0869565217391304 0.0193548387096774
GO:BP GO:0032355 response to estradiol 0.00883921513149394 141 27 3 0.111111111111111 0.0212765957446809
GO:BP GO:0030101 natural killer cell activation 0.00888425725871437 84 45 3 0.0666666666666667 0.0357142857142857
GO:BP GO:1901652 response to peptide 0.00889024492984855 551 54 7 0.12962962962963 0.0127041742286751
GO:BP GO:0002237 response to molecule of bacterial origin 0.00900792580286869 361 60 6 0.1 0.0166204986149584
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.00900792580286869 549 122 11 0.0901639344262295 0.0200364298724954
GO:BP GO:0051179 localization 0.00900792580286869 6901 75 42 0.56 0.00608607448195914
GO:BP GO:0071363 cellular response to growth factor stimulus 0.00923028245100557 731 21 5 0.238095238095238 0.00683994528043776
GO:BP GO:0021782 glial cell development 0.00933228233328138 122 70 4 0.0571428571428571 0.0327868852459016
GO:BP GO:0070528 protein kinase C signaling 0.00936886080202608 32 122 3 0.0245901639344262 0.09375
GO:BP GO:0065008 regulation of biological quality 0.00941939832242304 4131 126 44 0.349206349206349 0.0106511740498669
GO:BP GO:0048523 negative regulation of cellular process 0.00942151839765502 5139 135 55 0.407407407407407 0.0107024712979179
GO:BP GO:0071383 cellular response to steroid hormone stimulus 0.00942582968517983 210 19 3 0.157894736842105 0.0142857142857143
GO:BP GO:1904037 positive regulation of epithelial cell apoptotic process 0.00954607288669074 48 82 3 0.0365853658536585 0.0625
GO:BP GO:0051246 regulation of protein metabolic process 0.00964066673598555 2704 141 35 0.24822695035461 0.0129437869822485
GO:BP GO:0097553 calcium ion transmembrane import into cytosol 0.00964066673598555 145 60 4 0.0666666666666667 0.0275862068965517
GO:BP GO:0002761 regulation of myeloid leukocyte differentiation 0.00980144235662737 123 71 4 0.0563380281690141 0.032520325203252
GO:BP GO:0032869 cellular response to insulin stimulus 0.0103919120312592 235 95 6 0.0631578947368421 0.025531914893617
GO:BP GO:0070848 response to growth factor 0.0103919120312592 759 21 5 0.238095238095238 0.00658761528326746
GO:BP GO:0070527 platelet aggregation 0.0105296912548869 64 140 4 0.0285714285714286 0.0625
GO:BP GO:1900182 positive regulation of protein localization to nucleus 0.0106906190237364 90 46 3 0.0652173913043478 0.0333333333333333
GO:BP GO:0034405 response to fluid shear stress 0.0108639969746911 37 113 3 0.0265486725663717 0.0810810810810811
GO:BP GO:0045444 fat cell differentiation 0.0109525156301118 229 134 7 0.0522388059701493 0.0305676855895196
GO:BP GO:0002763 positive regulation of myeloid leukocyte differentiation 0.0110234378997088 59 71 3 0.0422535211267606 0.0508474576271186
GO:BP GO:0046651 lymphocyte proliferation 0.0113216323148341 294 53 5 0.0943396226415094 0.0170068027210884
GO:BP GO:0043405 regulation of MAP kinase activity 0.0113449827135241 316 126 8 0.0634920634920635 0.0253164556962025
GO:BP GO:0048545 response to steroid hormone 0.0113817117230078 349 27 4 0.148148148148148 0.0114613180515759
GO:BP GO:1901699 cellular response to nitrogen compound 0.0114018940079269 724 97 11 0.11340206185567 0.0151933701657459
GO:BP GO:0051651 maintenance of location in cell 0.0115504386472811 223 70 5 0.0714285714285714 0.0224215246636771
GO:BP GO:0032943 mononuclear cell proliferation 0.0116350130153454 297 53 5 0.0943396226415094 0.0168350168350168
GO:BP GO:0032502 developmental process 0.0116350130153454 6628 141 69 0.48936170212766 0.0104103802051901
GO:BP GO:0010001 glial cell differentiation 0.0118997953668377 225 70 5 0.0714285714285714 0.0222222222222222
GO:BP GO:0071347 cellular response to interleukin-1 0.0120434236112585 185 24 3 0.125 0.0162162162162162
GO:BP GO:0007173 epidermal growth factor receptor signaling pathway 0.0120434236112585 123 128 5 0.0390625 0.040650406504065
GO:BP GO:0031623 receptor internalization 0.0120877081375578 116 136 5 0.0367647058823529 0.0431034482758621
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0120877081375578 2541 141 33 0.234042553191489 0.012987012987013
GO:BP GO:1903169 regulation of calcium ion transmembrane transport 0.0122468299212407 158 60 4 0.0666666666666667 0.0253164556962025
GO:BP GO:0051279 regulation of release of sequestered calcium ion into cytosol 0.0122774429276487 85 52 3 0.0576923076923077 0.0352941176470588
GO:BP GO:0002698 negative regulation of immune effector process 0.0123810149429591 125 76 4 0.0526315789473684 0.032
GO:BP GO:0014910 regulation of smooth muscle cell migration 0.0128692889337415 85 113 4 0.0353982300884956 0.0470588235294118
GO:BP GO:0009968 negative regulation of signal transduction 0.0129165522417107 1364 54 11 0.203703703703704 0.00806451612903226
GO:BP GO:0046777 protein autophosphorylation 0.0133713677113568 240 134 7 0.0522388059701493 0.0291666666666667
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.0134875087689079 456 134 10 0.0746268656716418 0.0219298245614035
GO:BP GO:0032479 regulation of type I interferon production 0.0138030461887147 130 126 5 0.0396825396825397 0.0384615384615385
GO:BP GO:0060402 calcium ion transport into cytosol 0.0139097610148684 165 60 4 0.0666666666666667 0.0242424242424242
GO:BP GO:0009991 response to extracellular stimulus 0.014031827715839 512 82 8 0.0975609756097561 0.015625
GO:BP GO:0032606 type I interferon production 0.0141714712294543 131 126 5 0.0396825396825397 0.0381679389312977
GO:BP GO:0009888 tissue development 0.0144908977501075 2107 70 17 0.242857142857143 0.00806834361651637
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.0146906822150885 3087 142 38 0.267605633802817 0.0123096857790735
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.0148014810649379 1477 141 22 0.156028368794326 0.014895057549086
GO:BP GO:0002573 myeloid leukocyte differentiation 0.0149925830802824 213 79 5 0.0632911392405063 0.0234741784037559
GO:BP GO:0002260 lymphocyte homeostasis 0.0150151328220873 61 79 3 0.0379746835443038 0.0491803278688525
GO:BP GO:0048589 developmental growth 0.0151945984138243 649 27 5 0.185185185185185 0.00770416024653313
GO:BP GO:0051239 regulation of multicellular organismal process 0.0154066320507146 2861 71 21 0.295774647887324 0.00734009087731562
GO:BP GO:0048146 positive regulation of fibroblast proliferation 0.015858245513409 51 97 3 0.0309278350515464 0.0588235294117647
GO:BP GO:0071901 negative regulation of protein serine/threonine kinase activity 0.015858245513409 150 69 4 0.0579710144927536 0.0266666666666667
GO:BP GO:0010941 regulation of cell death 0.0159552559256524 1720 138 24 0.173913043478261 0.013953488372093
GO:BP GO:0051130 positive regulation of cellular component organization 0.0160929880422663 1153 126 17 0.134920634920635 0.0147441457068517
GO:BP GO:0031400 negative regulation of protein modification process 0.0161005411391028 578 75 8 0.106666666666667 0.013840830449827
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0161836116197123 1160 23 6 0.260869565217391 0.00517241379310345
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0161836116197123 3083 120 33 0.275 0.0107038598767434
GO:BP GO:0140029 exocytic process 0.0162068524411367 83 126 4 0.0317460317460317 0.0481927710843374
GO:BP GO:0006469 negative regulation of protein kinase activity 0.0162068524411367 251 69 5 0.072463768115942 0.0199203187250996
GO:BP GO:0006793 phosphorus metabolic process 0.0164051800851932 3114 142 38 0.267605633802817 0.0122029543994862
GO:BP GO:0014909 smooth muscle cell migration 0.0164376347652217 93 113 4 0.0353982300884956 0.043010752688172
GO:BP GO:0033280 response to vitamin D 0.0165461929504988 38 134 3 0.0223880597014925 0.0789473684210526
GO:BP GO:0070555 response to interleukin-1 0.0165960973148271 215 24 3 0.125 0.013953488372093
GO:BP GO:0071560 cellular response to transforming growth factor beta stimulus 0.0167976553175135 256 99 6 0.0606060606060606 0.0234375
GO:BP GO:0001894 tissue homeostasis 0.0168719823637259 270 126 7 0.0555555555555556 0.0259259259259259
GO:BP GO:0043067 regulation of programmed cell death 0.0170234472099919 1582 134 22 0.164179104477612 0.0139064475347661
GO:BP GO:0009636 response to toxic substance 0.0173499441616907 243 141 7 0.049645390070922 0.0288065843621399
GO:BP GO:0042100 B cell proliferation 0.0173499441616907 98 53 3 0.0566037735849057 0.0306122448979592
GO:BP GO:0071417 cellular response to organonitrogen compound 0.0173940944951769 666 113 11 0.0973451327433628 0.0165165165165165
GO:BP GO:0009743 response to carbohydrate 0.0174286744604177 243 73 5 0.0684931506849315 0.0205761316872428
GO:BP GO:0046822 regulation of nucleocytoplasmic transport 0.0178340199903763 115 46 3 0.0652173913043478 0.0260869565217391
GO:BP GO:0030162 regulation of proteolysis 0.0178837387007669 752 131 13 0.099236641221374 0.0172872340425532
GO:BP GO:0060348 bone development 0.0178837387007669 203 54 4 0.0740740740740741 0.0197044334975369
GO:BP GO:0010942 positive regulation of cell death 0.0178837387007669 684 127 12 0.094488188976378 0.0175438596491228
GO:BP GO:0008360 regulation of cell shape 0.0178837387007669 154 71 4 0.0563380281690141 0.025974025974026
GO:BP GO:0071559 response to transforming growth factor beta 0.0178852266653627 262 99 6 0.0606060606060606 0.0229007633587786
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.0178970311629926 251 44 4 0.0909090909090909 0.0159362549800797
GO:BP GO:0046686 response to cadmium ion 0.0179991769991062 65 82 3 0.0365853658536585 0.0461538461538462
GO:BP GO:0030154 cell differentiation 0.0179991769991062 4350 88 33 0.375 0.00758620689655172
GO:BP GO:0051049 regulation of transport 0.0180686051828158 1809 141 25 0.177304964539007 0.0138197899391929
GO:BP GO:0034121 regulation of toll-like receptor signaling pathway 0.0182969926549884 79 68 3 0.0441176470588235 0.0379746835443038
GO:BP GO:0051093 negative regulation of developmental process 0.0183737689906223 977 28 6 0.214285714285714 0.00614124872057318
GO:BP GO:0060401 cytosolic calcium ion transport 0.0185939662024913 186 60 4 0.0666666666666667 0.021505376344086
GO:BP GO:0017157 regulation of exocytosis 0.0188657351913733 207 127 6 0.047244094488189 0.0289855072463768
GO:BP GO:0032755 positive regulation of interleukin-6 production 0.0190637854381054 89 126 4 0.0317460317460317 0.0449438202247191
GO:BP GO:0051896 regulation of protein kinase B signaling 0.0190637854381054 259 102 6 0.0588235294117647 0.0231660231660232
GO:BP GO:0022612 gland morphogenesis 0.0191319519426616 120 46 3 0.0652173913043478 0.025
GO:BP GO:0010522 regulation of calcium ion transport into cytosol 0.0191319519426616 106 52 3 0.0576923076923077 0.0283018867924528
GO:BP GO:0014070 response to organic cyclic compound 0.0192580230259031 967 92 12 0.130434782608696 0.0124095139607032
GO:BP GO:0010648 negative regulation of cell communication 0.0192738487117554 1468 54 11 0.203703703703704 0.00749318801089918
GO:BP GO:0045596 negative regulation of cell differentiation 0.0194322295882372 697 52 7 0.134615384615385 0.0100430416068867
GO:BP GO:0023057 negative regulation of signaling 0.0194322295882372 1471 54 11 0.203703703703704 0.00747790618626785
GO:BP GO:0042246 tissue regeneration 0.0197207969713508 80 70 3 0.0428571428571429 0.0375
GO:BP GO:0070228 regulation of lymphocyte apoptotic process 0.019730870078001 55 102 3 0.0294117647058824 0.0545454545454545
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.0198155940998984 263 71 5 0.0704225352112676 0.0190114068441065
GO:BP GO:0007162 negative regulation of cell adhesion 0.0198155940998984 304 19 3 0.157894736842105 0.00986842105263158
GO:BP GO:0000302 response to reactive oxygen species 0.0198155940998984 237 113 6 0.0530973451327434 0.0253164556962025
GO:BP GO:0001501 skeletal system development 0.019983418368661 504 54 6 0.111111111111111 0.0119047619047619
GO:BP GO:1901698 response to nitrogen compound 0.0199979752259594 1172 97 14 0.144329896907216 0.0119453924914676
GO:BP GO:0007275 multicellular organism development 0.0204034400180502 5613 127 54 0.425196850393701 0.00962052378407269
GO:BP GO:0009266 response to temperature stimulus 0.0215798395148451 228 52 4 0.0769230769230769 0.0175438596491228
GO:BP GO:0071407 cellular response to organic cyclic compound 0.0218062856746928 587 21 4 0.19047619047619 0.00681431005110733
GO:BP GO:1904035 regulation of epithelial cell apoptotic process 0.021888361150361 105 113 4 0.0353982300884956 0.0380952380952381
GO:BP GO:0007417 central nervous system development 0.0221321094029417 1032 28 6 0.214285714285714 0.00581395348837209
GO:BP GO:0048869 cellular developmental process 0.0221321094029417 4428 88 33 0.375 0.00745257452574526
GO:BP GO:0043068 positive regulation of programmed cell death 0.0221415232749194 621 127 11 0.0866141732283465 0.0177133655394525
GO:BP GO:0006954 inflammatory response 0.0223091923273016 794 129 13 0.10077519379845 0.0163727959697733
GO:BP GO:0014812 muscle cell migration 0.0223193238426466 106 113 4 0.0353982300884956 0.0377358490566038
GO:BP GO:0006629 lipid metabolic process 0.0223193238426466 1457 132 20 0.151515151515152 0.0137268359643102
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.0223764079680201 325 60 5 0.0833333333333333 0.0153846153846154
GO:BP GO:0010243 response to organonitrogen compound 0.0225265964381252 1085 54 9 0.166666666666667 0.00829493087557604
GO:BP GO:0031670 cellular response to nutrient 0.0225746698275703 45 134 3 0.0223880597014925 0.0666666666666667
GO:BP GO:0034109 homotypic cell-cell adhesion 0.0230153161125579 87 140 4 0.0285714285714286 0.0459770114942529
GO:BP GO:0051046 regulation of secretion 0.0231787910411393 647 141 12 0.0851063829787234 0.0185471406491499
GO:BP GO:0097190 apoptotic signaling pathway 0.0239883002744143 600 11 3 0.272727272727273 0.005
GO:BP GO:0006915 apoptotic process 0.0240449141068043 1990 119 23 0.19327731092437 0.0115577889447236
GO:BP GO:0045862 positive regulation of proteolysis 0.0242168132654642 378 126 8 0.0634920634920635 0.0211640211640212
GO:BP GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway 0.024410214597935 49 128 3 0.0234375 0.0612244897959184
GO:BP GO:0046173 polyol biosynthetic process 0.0244344750116979 64 98 3 0.0306122448979592 0.046875
GO:BP GO:0006464 cellular protein modification process 0.0244344750116979 4041 137 44 0.321167883211679 0.0108883939618906
GO:BP GO:0036211 protein modification process 0.0244344750116979 4041 137 44 0.321167883211679 0.0108883939618906
GO:BP GO:0043408 regulation of MAPK cascade 0.0247306922552545 730 53 7 0.132075471698113 0.00958904109589041
GO:BP GO:0051050 positive regulation of transport 0.0251769382189655 923 127 14 0.110236220472441 0.0151679306608884
GO:BP GO:1900180 regulation of protein localization to nucleus 0.0251769382189655 139 46 3 0.0652173913043478 0.0215827338129496
GO:BP GO:0042221 response to chemical 0.0253097372316192 4781 127 47 0.37007874015748 0.00983057937669943
GO:BP GO:0033044 regulation of chromosome organization 0.0253097372316192 279 46 4 0.0869565217391304 0.014336917562724
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.0253097372316192 291 44 4 0.0909090909090909 0.013745704467354
GO:BP GO:0051403 stress-activated MAPK cascade 0.0253097372316192 272 24 3 0.125 0.0110294117647059
GO:BP GO:0002312 B cell activation involved in immune response 0.0253097372316192 79 81 3 0.037037037037037 0.0379746835443038
GO:BP GO:0045807 positive regulation of endocytosis 0.0253172769934738 101 126 4 0.0317460317460317 0.0396039603960396
GO:BP GO:0043491 protein kinase B signaling 0.0258274161451567 286 102 6 0.0588235294117647 0.020979020979021
GO:BP GO:0044706 multi-multicellular organism process 0.0259274947538654 227 57 4 0.0701754385964912 0.0176211453744493
GO:BP GO:0071230 cellular response to amino acid stimulus 0.0265080947232729 68 97 3 0.0309278350515464 0.0441176470588235
GO:BP GO:0031669 cellular response to nutrient levels 0.0265112685927842 219 134 6 0.0447761194029851 0.0273972602739726
GO:BP GO:0031647 regulation of protein stability 0.0274031126662616 300 70 5 0.0714285714285714 0.0166666666666667
GO:BP GO:0034504 protein localization to nucleus 0.0275387665895022 289 46 4 0.0869565217391304 0.013840830449827
GO:BP GO:0046626 regulation of insulin receptor signaling pathway 0.0275538663758654 71 95 3 0.0315789473684211 0.0422535211267606
GO:BP GO:0008610 lipid biosynthetic process 0.0275538663758654 740 82 9 0.109756097560976 0.0121621621621622
GO:BP GO:0031667 response to nutrient levels 0.0275538663758654 482 82 7 0.0853658536585366 0.0145228215767635
GO:BP GO:0009913 epidermal cell differentiation 0.0276954769897109 365 82 6 0.0731707317073171 0.0164383561643836
GO:BP GO:0048260 positive regulation of receptor-mediated endocytosis 0.027699881352825 54 126 3 0.0238095238095238 0.0555555555555556
GO:BP GO:0001776 leukocyte homeostasis 0.027699881352825 86 79 3 0.0379746835443038 0.0348837209302326
GO:BP GO:1903530 regulation of secretion by cell 0.027699881352825 588 141 11 0.0780141843971631 0.0187074829931973
GO:BP GO:0031098 stress-activated protein kinase signaling cascade 0.027699881352825 288 24 3 0.125 0.0104166666666667
GO:BP GO:0010638 positive regulation of organelle organization 0.0280921356584357 603 119 10 0.0840336134453782 0.0165837479270315
GO:BP GO:0030203 glycosaminoglycan metabolic process 0.028743119486848 159 134 5 0.0373134328358209 0.0314465408805031
GO:BP GO:0071902 positive regulation of protein serine/threonine kinase activity 0.028812050741566 316 126 7 0.0555555555555556 0.0221518987341772
GO:BP GO:0048519 negative regulation of biological process 0.0288457782643362 5757 135 57 0.422222222222222 0.0099009900990099
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.0291150886421221 360 60 5 0.0833333333333333 0.0138888888888889
GO:BP GO:0050806 positive regulation of synaptic transmission 0.02914241593045 152 141 5 0.0354609929078014 0.0328947368421053
GO:BP GO:0006606 protein import into nucleus 0.02914241593045 152 46 3 0.0652173913043478 0.0197368421052632
GO:BP GO:1903307 positive regulation of regulated secretory pathway 0.0291710396291213 55 127 3 0.0236220472440945 0.0545454545454545
GO:BP GO:0046890 regulation of lipid biosynthetic process 0.0292752073961527 215 100 5 0.05 0.0232558139534884
GO:BP GO:0043065 positive regulation of apoptotic process 0.0299361288054552 604 102 9 0.0882352941176471 0.0149006622516556
GO:BP GO:2000351 regulation of endothelial cell apoptotic process 0.0303853927887526 63 113 3 0.0265486725663717 0.0476190476190476
GO:BP GO:0045123 cellular extravasation 0.0305702002687532 70 102 3 0.0294117647058824 0.0428571428571429
GO:BP GO:0044272 sulfur compound biosynthetic process 0.0305702002687532 193 113 5 0.0442477876106195 0.0259067357512953
GO:BP GO:0002090 regulation of receptor internalization 0.0307769436516579 57 126 3 0.0238095238095238 0.0526315789473684
GO:BP GO:0008286 insulin receptor signaling pathway 0.0318022268049183 148 95 4 0.0421052631578947 0.027027027027027
GO:BP GO:0048259 regulation of receptor-mediated endocytosis 0.0320243648808951 112 126 4 0.0317460317460317 0.0357142857142857
GO:BP GO:0071229 cellular response to acid chemical 0.0323715329893695 76 97 3 0.0309278350515464 0.0394736842105263
GO:BP GO:0043412 macromolecule modification 0.0323715329893695 4257 137 45 0.328467153284672 0.0105708245243129
GO:BP GO:0062197 cellular response to chemical stress 0.0325405144790927 365 113 7 0.0619469026548673 0.0191780821917808
GO:BP GO:0032956 regulation of actin cytoskeleton organization 0.0325615511493097 366 141 8 0.0567375886524823 0.0218579234972678
GO:BP GO:0040008 regulation of growth 0.0326163003743811 681 47 6 0.127659574468085 0.00881057268722467
GO:BP GO:0007517 muscle organ development 0.0333831481908118 333 68 5 0.0735294117647059 0.015015015015015
GO:BP GO:0070227 lymphocyte apoptotic process 0.0337345172540643 74 102 3 0.0294117647058824 0.0405405405405405
GO:BP GO:1904019 epithelial cell apoptotic process 0.0338831894334688 128 113 4 0.0353982300884956 0.03125
GO:BP GO:0032233 positive regulation of actin filament bundle assembly 0.0340421297003929 64 119 3 0.0252100840336134 0.046875
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.034109053114096 2719 108 26 0.240740740740741 0.00956233909525561
GO:BP GO:0072577 endothelial cell apoptotic process 0.0346807982302003 68 113 3 0.0265486725663717 0.0441176470588235
GO:BP GO:1903509 liposaccharide metabolic process 0.0348304239762825 113 130 4 0.0307692307692308 0.0353982300884956
GO:BP GO:2001252 positive regulation of chromosome organization 0.0348304239762825 168 46 3 0.0652173913043478 0.0178571428571429
GO:BP GO:0032147 activation of protein kinase activity 0.0355907044771543 331 24 3 0.125 0.00906344410876133
GO:BP GO:0030865 cortical cytoskeleton organization 0.0355907044771543 63 124 3 0.0241935483870968 0.0476190476190476
GO:BP GO:0006022 aminoglycan metabolic process 0.0357731295875367 173 134 5 0.0373134328358209 0.0289017341040462
GO:BP GO:0044092 negative regulation of molecular function 0.0358280817791555 1219 54 9 0.166666666666667 0.007383100902379
GO:BP GO:0032231 regulation of actin filament bundle assembly 0.0359676796983915 106 141 4 0.0283687943262411 0.0377358490566038
GO:BP GO:0051170 import into nucleus 0.0359676796983915 172 46 3 0.0652173913043478 0.0174418604651163
GO:BP GO:0048731 system development 0.0362234223254199 5052 127 48 0.377952755905512 0.00950118764845606
GO:BP GO:0050810 regulation of steroid biosynthetic process 0.0366079674746812 97 82 3 0.0365853658536585 0.0309278350515464
GO:BP GO:0051235 maintenance of location 0.0367471963249439 337 70 5 0.0714285714285714 0.0148367952522255
GO:BP GO:0050789 regulation of biological process 0.0367471963249439 12091 17 16 0.941176470588235 0.00132329832106526
GO:BP GO:0045834 positive regulation of lipid metabolic process 0.037478085325017 155 52 3 0.0576923076923077 0.0193548387096774
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.037478085325017 155 52 3 0.0576923076923077 0.0193548387096774
GO:BP GO:0043112 receptor metabolic process 0.0378360377460312 174 136 5 0.0367647058823529 0.028735632183908
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.0380635603698078 185 44 3 0.0681818181818182 0.0162162162162162
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.0386162031858454 190 81 4 0.0493827160493827 0.0210526315789474
GO:BP GO:0006790 sulfur compound metabolic process 0.0390945340467872 386 113 7 0.0619469026548673 0.0181347150259067
GO:BP GO:0051924 regulation of calcium ion transport 0.0392178547931512 259 60 4 0.0666666666666667 0.0154440154440154
GO:BP GO:0009408 response to heat 0.0393355641286904 159 52 3 0.0576923076923077 0.0188679245283019
GO:BP GO:0055082 cellular chemical homeostasis 0.0395268329694477 841 79 9 0.113924050632911 0.0107015457788347
GO:BP GO:0044255 cellular lipid metabolic process 0.0395376626145664 1075 143 16 0.111888111888112 0.0148837209302326
GO:BP GO:1903510 mucopolysaccharide metabolic process 0.039597781153898 116 134 4 0.0298507462686567 0.0344827586206897
GO:BP GO:0006874 cellular calcium ion homeostasis 0.0399650246905124 460 119 8 0.0672268907563025 0.0173913043478261
GO:BP GO:0034284 response to monosaccharide 0.0401933388266102 215 73 4 0.0547945205479452 0.0186046511627907
GO:BP GO:0045595 regulation of cell differentiation 0.0401933388266102 1679 117 19 0.162393162393162 0.01131625967838
GO:BP GO:2000106 regulation of leukocyte apoptotic process 0.0402695991927345 82 102 3 0.0294117647058824 0.0365853658536585
GO:BP GO:0002576 platelet degranulation 0.0414222040008512 126 126 4 0.0317460317460317 0.0317460317460317
GO:BP GO:0046834 lipid phosphorylation 0.0416990483614422 70 122 3 0.0245901639344262 0.0428571428571429
GO:BP GO:0048871 multicellular organismal homeostasis 0.0417798102726836 530 126 9 0.0714285714285714 0.0169811320754717
GO:BP GO:0045453 bone resorption 0.0418705693733181 68 126 3 0.0238095238095238 0.0441176470588235
GO:BP GO:0010959 regulation of metal ion transport 0.042005910297574 268 60 4 0.0666666666666667 0.0149253731343284
GO:BP GO:0006694 steroid biosynthetic process 0.0423420427381123 196 82 4 0.0487804878048781 0.0204081632653061
GO:BP GO:0045597 positive regulation of cell differentiation 0.0427446813058058 879 52 7 0.134615384615385 0.00796359499431172
GO:BP GO:0030216 keratinocyte differentiation 0.0427446813058058 304 82 5 0.0609756097560976 0.0164473684210526
GO:BP GO:0060322 head development 0.0427446813058058 798 21 4 0.19047619047619 0.0050125313283208
GO:BP GO:0006913 nucleocytoplasmic transport 0.0427446813058058 354 46 4 0.0869565217391304 0.0112994350282486
GO:BP GO:0006911 phagocytosis, engulfment 0.0427446813058058 127 127 4 0.031496062992126 0.031496062992126
GO:BP GO:0006024 glycosaminoglycan biosynthetic process 0.0427446813058058 107 81 3 0.037037037037037 0.0280373831775701
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.0427446813058058 213 76 4 0.0526315789473684 0.0187793427230047
GO:BP GO:0042981 regulation of apoptotic process 0.0430753019206518 1549 102 16 0.156862745098039 0.0103292446739832
GO:BP GO:0055074 calcium ion homeostasis 0.0430753019206518 472 119 8 0.0672268907563025 0.0169491525423729
GO:BP GO:0051169 nuclear transport 0.0430753019206518 357 46 4 0.0869565217391304 0.0112044817927171
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.0431244673742946 1082 53 8 0.150943396226415 0.00739371534195933
GO:BP GO:0043086 negative regulation of catalytic activity 0.0431244673742946 851 54 7 0.12962962962963 0.0082256169212691
GO:BP GO:1901654 response to ketone 0.0431643233128544 204 123 5 0.040650406504065 0.0245098039215686
GO:BP GO:0006898 receptor-mediated endocytosis 0.0434008472006942 333 136 7 0.0514705882352941 0.021021021021021
GO:BP GO:0044089 positive regulation of cellular component biogenesis 0.0439736378303649 540 126 9 0.0714285714285714 0.0166666666666667
GO:BP GO:0051345 positive regulation of hydrolase activity 0.043996376995451 783 12 3 0.25 0.00383141762452107
GO:BP GO:0044267 cellular protein metabolic process 0.0441890273497669 5229 137 52 0.37956204379562 0.00994454006502199
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 0.0442276052012059 162 102 4 0.0392156862745098 0.0246913580246914
GO:BP GO:1902905 positive regulation of supramolecular fiber organization 0.0447359465630401 214 119 5 0.0420168067226891 0.0233644859813084
GO:BP GO:2000177 regulation of neural precursor cell proliferation 0.0448760760284452 91 99 3 0.0303030303030303 0.032967032967033
GO:BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 0.0449964812661718 93 97 3 0.0309278350515464 0.032258064516129
GO:BP GO:0019538 protein metabolic process 0.0460393463373793 5808 141 58 0.411347517730496 0.0099862258953168
GO:BP GO:0052548 regulation of endopeptidase activity 0.0460393463373793 437 131 8 0.0610687022900763 0.0183066361556064
GO:BP GO:0032970 regulation of actin filament-based process 0.0461818143569236 406 141 8 0.0567375886524823 0.0197044334975369
GO:BP GO:0034599 cellular response to oxidative stress 0.0462518416511447 316 113 6 0.0530973451327434 0.0189873417721519
GO:BP GO:0007259 receptor signaling pathway via JAK-STAT 0.0463393737917089 174 53 3 0.0566037735849057 0.0172413793103448
GO:BP GO:0097237 cellular response to toxic substance 0.0464447085101996 120 141 4 0.0283687943262411 0.0333333333333333
GO:BP GO:0006023 aminoglycan biosynthetic process 0.0466155605405924 114 81 3 0.037037037037037 0.0263157894736842
GO:BP GO:0007565 female pregnancy 0.0469207996104809 198 47 3 0.0638297872340425 0.0151515151515152
GO:BP GO:0030522 intracellular receptor signaling pathway 0.0473869616009106 284 92 5 0.0543478260869565 0.0176056338028169
GO:BP GO:0080090 regulation of primary metabolic process 0.0477985347537322 6053 136 58 0.426470588235294 0.00958202544192962
GO:BP GO:0017038 protein import 0.0480539238824172 205 46 3 0.0652173913043478 0.0146341463414634
GO:BP GO:0099024 plasma membrane invagination 0.0487503544588882 136 127 4 0.031496062992126 0.0294117647058824
GO:BP GO:0042742 defense response to bacterium 0.0489479909548906 349 50 4 0.08 0.0114613180515759
GO:BP GO:0007163 establishment or maintenance of cell polarity 0.0490203149130206 220 79 4 0.0506329113924051 0.0181818181818182
GO:BP GO:0006897 endocytosis 0.0493638689946719 696 136 11 0.0808823529411765 0.0158045977011494
GO:CC GO:0031410 cytoplasmic vesicle 6.44384566636786e-07 2424 137 44 0.321167883211679 0.0181518151815182
GO:CC GO:0097708 intracellular vesicle 6.44384566636786e-07 2428 137 44 0.321167883211679 0.0181219110378913
GO:CC GO:0030141 secretory granule 2.56652639139125e-06 851 131 23 0.175572519083969 0.027027027027027
GO:CC GO:0099503 secretory vesicle 2.91547991304092e-06 1020 131 25 0.190839694656489 0.0245098039215686
GO:CC GO:0101002 ficolin-1-rich granule 5.17293000435998e-06 184 131 11 0.083969465648855 0.0597826086956522
GO:CC GO:0031982 vesicle 4.37213558998834e-05 4055 138 55 0.398550724637681 0.0135635018495684
GO:CC GO:0012505 endomembrane system 4.37213558998834e-05 4640 138 60 0.434782608695652 0.0129310344827586
GO:CC GO:0070820 tertiary granule 0.000828109012098272 163 131 8 0.0610687022900763 0.049079754601227
GO:CC GO:0101003 ficolin-1-rich granule membrane 0.000828109012098272 60 102 5 0.0490196078431373 0.0833333333333333
GO:CC GO:0002102 podosome 0.000858477185286777 28 111 4 0.036036036036036 0.142857142857143
GO:CC GO:0030667 secretory granule membrane 0.00143822493623724 303 102 9 0.0882352941176471 0.0297029702970297
GO:CC GO:0071944 cell periphery 0.00170650767958401 6169 142 69 0.485915492957746 0.0111849570432809
GO:CC GO:0098588 bounding membrane of organelle 0.0027111161793416 2158 128 30 0.234375 0.0139017608897127
GO:CC GO:0005886 plasma membrane 0.0029033892061228 5681 142 64 0.450704225352113 0.0112656222496039
GO:CC GO:0000323 lytic vacuole 0.00299632001511666 712 102 13 0.127450980392157 0.0182584269662921
GO:CC GO:0005764 lysosome 0.00299632001511666 712 102 13 0.127450980392157 0.0182584269662921
GO:CC GO:0070821 tertiary granule membrane 0.00300755085312745 72 127 5 0.0393700787401575 0.0694444444444444
GO:CC GO:0009986 cell surface 0.00415490429054499 899 19 6 0.315789473684211 0.00667408231368187
GO:CC GO:0098552 side of membrane 0.00432862356943175 619 77 10 0.12987012987013 0.0161550888529887
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.00467105650427668 124 131 6 0.0458015267175573 0.0483870967741935
GO:CC GO:0009897 external side of plasma membrane 0.00577845138873282 408 16 4 0.25 0.00980392156862745
GO:CC GO:0005773 vacuole 0.00700630713458274 810 102 13 0.127450980392157 0.0160493827160494
GO:CC GO:0005737 cytoplasm 0.0112008023550859 11911 144 109 0.756944444444444 0.0091512047687012
GO:CC GO:0005615 extracellular space 0.0114674093788825 3594 70 25 0.357142857142857 0.00695603784084585
GO:CC GO:0005576 extracellular region 0.0132580083146904 4567 82 33 0.402439024390244 0.00722574994525947
GO:CC GO:0034774 secretory granule lumen 0.0158201652064919 320 70 6 0.0857142857142857 0.01875
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0158201652064919 779 103 12 0.116504854368932 0.0154043645699615
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0163322709475995 324 70 6 0.0857142857142857 0.0185185185185185
GO:CC GO:0031983 vesicle lumen 0.0163434166829159 326 70 6 0.0857142857142857 0.0184049079754601
GO:CC GO:0012506 vesicle membrane 0.0163710145603164 800 103 12 0.116504854368932 0.015
GO:CC GO:0008305 integrin complex 0.0186468510768976 32 140 3 0.0214285714285714 0.09375
GO:CC GO:0005887 integral component of plasma membrane 0.0186468510768976 1645 16 6 0.375 0.00364741641337386
GO:CC GO:0016020 membrane 0.0186468510768976 9838 136 88 0.647058823529412 0.0089449075015247
GO:CC GO:0098802 plasma membrane signaling receptor complex 0.0189821109056232 300 140 8 0.0571428571428571 0.0266666666666667
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0212701830716619 1726 16 6 0.375 0.00347624565469293
GO:CC GO:0005829 cytosol 0.0216157438795244 5303 75 33 0.44 0.00622289270224401
GO:CC GO:0001726 ruffle 0.0231099510916216 179 142 6 0.0422535211267606 0.0335195530726257
GO:CC GO:0098636 protein complex involved in cell adhesion 0.024886244364458 37 140 3 0.0214285714285714 0.0810810810810811
GO:CC GO:0042582 azurophil granule 0.0334360797050539 154 130 5 0.0384615384615385 0.0324675324675325
GO:CC GO:0019897 extrinsic component of plasma membrane 0.0334360797050539 176 71 4 0.0563380281690141 0.0227272727272727
GO:CC GO:0016021 integral component of membrane 0.0334360797050539 5711 102 44 0.431372549019608 0.00770443004727718
GO:CC GO:0000139 Golgi membrane 0.0334360797050539 771 138 13 0.0942028985507246 0.0168612191958495
GO:CC GO:0005766 primary lysosome 0.0334360797050539 154 130 5 0.0384615384615385 0.0324675324675325
GO:CC GO:0098852 lytic vacuole membrane 0.0334360797050539 383 100 7 0.07 0.0182767624020888
GO:CC GO:0005765 lysosomal membrane 0.0334360797050539 383 100 7 0.07 0.0182767624020888
GO:CC GO:0098796 membrane protein complex 0.0334360797050539 1322 140 19 0.135714285714286 0.0143721633888048
GO:CC GO:0031252 cell leading edge 0.03484679823689 422 142 9 0.0633802816901408 0.0213270142180095
GO:CC GO:0070062 extracellular exosome 0.0355211446875426 2176 82 18 0.219512195121951 0.00827205882352941
GO:CC GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 0.0355211446875426 102 126 4 0.0317460317460317 0.0392156862745098
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0375397214485295 885 138 14 0.101449275362319 0.015819209039548
GO:CC GO:0032587 ruffle membrane 0.0398616847825711 96 142 4 0.028169014084507 0.0416666666666667
GO:CC GO:0031224 intrinsic component of membrane 0.0410049720704022 5868 102 44 0.431372549019608 0.00749829584185412
GO:CC GO:0019898 extrinsic component of membrane 0.0417332978140758 313 71 5 0.0704225352112676 0.0159744408945687
GO:CC GO:0005794 Golgi apparatus 0.0437442406834983 1623 138 21 0.152173913043478 0.0129390018484288
GO:CC GO:0043230 extracellular organelle 0.0446939611328673 2263 82 18 0.219512195121951 0.00795404330534688
GO:CC GO:1903561 extracellular vesicle 0.0446939611328673 2261 82 18 0.219512195121951 0.00796107916850951
GO:CC GO:0043235 receptor complex 0.0485129552292455 522 16 3 0.1875 0.00574712643678161
GO:CC GO:0005938 cell cortex 0.0485129552292455 311 141 7 0.049645390070922 0.022508038585209
GO:CC GO:0031090 organelle membrane 0.0485129552292455 3612 103 30 0.29126213592233 0.00830564784053156
GO:CC GO:0005774 vacuolar membrane 0.0485129552292455 441 100 7 0.07 0.0158730158730159
GO:MF GO:0004715 non-membrane spanning protein tyrosine kinase activity 0.000333616434685676 46 126 6 0.0476190476190476 0.130434782608696
GO:MF GO:0140375 immune receptor activity 0.00111154274105215 133 16 4 0.25 0.0300751879699248
GO:MF GO:0019900 kinase binding 0.00619507866800341 752 126 16 0.126984126984127 0.0212765957446809
GO:MF GO:0005102 signaling receptor binding 0.009889618290162 1672 97 21 0.216494845360825 0.0125598086124402
GO:MF GO:0001784 phosphotyrosine residue binding 0.0106140517529192 44 126 4 0.0317460317460317 0.0909090909090909
GO:MF GO:0004713 protein tyrosine kinase activity 0.0106140517529192 144 71 5 0.0704225352112676 0.0347222222222222
GO:MF GO:0051219 phosphoprotein binding 0.0106140517529192 88 60 4 0.0666666666666667 0.0454545454545455
GO:MF GO:0004888 transmembrane signaling receptor activity 0.0154936032493558 1269 16 6 0.375 0.00472813238770686
GO:MF GO:0019838 growth factor binding 0.0154936032493558 138 47 4 0.0851063829787234 0.0289855072463768
GO:MF GO:0019901 protein kinase binding 0.0156377168558582 673 141 14 0.099290780141844 0.0208023774145617
GO:MF GO:0045309 protein phosphorylated amino acid binding 0.0156377168558582 56 126 4 0.0317460317460317 0.0714285714285714
GO:MF GO:0060089 molecular transducer activity 0.0185552912820779 1458 16 6 0.375 0.00411522633744856
GO:MF GO:0038023 signaling receptor activity 0.0185552912820779 1458 16 6 0.375 0.00411522633744856
GO:MF GO:0042287 MHC protein binding 0.0185552912820779 39 87 3 0.0344827586206897 0.0769230769230769
GO:MF GO:0035257 nuclear hormone receptor binding 0.0185552912820779 148 92 5 0.0543478260869565 0.0337837837837838
GO:MF GO:0019207 kinase regulator activity 0.0185552912820779 221 95 6 0.0631578947368421 0.0271493212669683
GO:MF GO:0016773 phosphotransferase activity, alcohol group as acceptor 0.0220349646605263 692 134 13 0.0970149253731343 0.0187861271676301
GO:MF GO:0042802 identical protein binding 0.0220349646605263 2067 3 3 1 0.00145137880986938
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.0220349646605263 281 113 7 0.0619469026548673 0.0249110320284698
GO:MF GO:0004672 protein kinase activity 0.0242183495756272 587 29 5 0.172413793103448 0.00851788756388416
GO:MF GO:0051427 hormone receptor binding 0.0251850888170729 182 92 5 0.0543478260869565 0.0274725274725275
GO:MF GO:0005126 cytokine receptor binding 0.0274345909751847 275 19 3 0.157894736842105 0.0109090909090909
GO:MF GO:0019887 protein kinase regulator activity 0.0274345909751847 191 135 6 0.0444444444444444 0.031413612565445
GO:MF GO:0002020 protease binding 0.0274345909751847 133 131 5 0.0381679389312977 0.037593984962406
GO:MF GO:0042803 protein homodimerization activity 0.0274345909751847 676 98 10 0.102040816326531 0.014792899408284
GO:MF GO:0140297 DNA-binding transcription factor binding 0.0274345909751847 391 115 8 0.0695652173913043 0.020460358056266
GO:MF GO:0008134 transcription factor binding 0.0277470655751528 676 115 11 0.0956521739130435 0.0162721893491124
GO:MF GO:0005515 protein binding 0.0296461206134315 14767 58 54 0.931034482758621 0.00365680232951852
GO:MF GO:0005125 cytokine activity 0.034919704983348 235 27 3 0.111111111111111 0.0127659574468085
GO:MF GO:0019899 enzyme binding 0.0352627779151921 2074 131 25 0.190839694656489 0.0120540019286403
GO:MF GO:0016301 kinase activity 0.0352627779151921 796 134 13 0.0970149253731343 0.0163316582914573
GO:MF GO:0048018 receptor ligand activity 0.0374108058752573 494 27 4 0.148148148148148 0.00809716599190283
GO:MF GO:0030546 signaling receptor activator activity 0.0378244584213767 501 27 4 0.148148148148148 0.00798403193612774
GO:MF GO:0030545 receptor regulator activity 0.0466866751232973 545 27 4 0.148148148148148 0.0073394495412844
KEGG KEGG:04650 Natural killer cell mediated cytotoxicity 3.32557243137331e-06 123 21 7 0.333333333333333 0.0569105691056911
KEGG KEGG:04380 Osteoclast differentiation 0.00143043439585924 125 21 5 0.238095238095238 0.04
KEGG KEGG:04659 Th17 cell differentiation 0.00906727036801511 104 21 4 0.19047619047619 0.0384615384615385
KEGG KEGG:00533 Glycosaminoglycan biosynthesis - keratan sulfate 0.0167881271158715 14 81 3 0.037037037037037 0.214285714285714
KEGG KEGG:05140 Leishmaniasis 0.0282599713489121 72 21 3 0.142857142857143 0.0416666666666667
KEGG KEGG:04061 Viral protein interaction with cytokine and cytokine receptor 0.0282599713489121 98 16 3 0.1875 0.0306122448979592
KEGG KEGG:05152 Tuberculosis 0.0282599713489121 175 21 4 0.19047619047619 0.0228571428571429
KEGG KEGG:04666 Fc gamma R-mediated phagocytosis 0.0307992926224418 96 70 5 0.0714285714285714 0.0520833333333333
KEGG KEGG:04658 Th1 and Th2 cell differentiation 0.0307992926224418 89 21 3 0.142857142857143 0.0337078651685393
KEGG KEGG:04664 Fc epsilon RI signaling pathway 0.0307992926224418 67 60 4 0.0666666666666667 0.0597014925373134
KEGG KEGG:05142 Chagas disease 0.0400247628827249 101 21 3 0.142857142857143 0.0297029702970297
KEGG KEGG:04062 Chemokine signaling pathway 0.0415832327172153 190 60 6 0.1 0.0315789473684211
KEGG KEGG:05145 Toxoplasmosis 0.0415832327172153 109 21 3 0.142857142857143 0.0275229357798165
KEGG KEGG:05210 Colorectal cancer 0.0415832327172153 86 27 3 0.111111111111111 0.0348837209302326
KEGG KEGG:04660 T cell receptor signaling pathway 0.0459387343149878 103 24 3 0.125 0.029126213592233
REAC REAC:R-HSA-168249 Innate Immune System 0.00106900257919237 1073 79 22 0.278481012658228 0.0205032618825722
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.00106900257919237 181 15 5 0.333333333333333 0.0276243093922652
REAC REAC:R-HSA-168256 Immune System 0.00106900257919237 2139 29 17 0.586206896551724 0.00794763908368396
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.00106900257919237 474 131 19 0.145038167938931 0.040084388185654
REAC REAC:R-HSA-982772 Growth hormone receptor signaling 0.0181270432517432 23 52 3 0.0576923076923077 0.130434782608696
REAC REAC:R-HSA-2424491 DAP12 signaling 0.0181270432517432 25 126 4 0.0317460317460317 0.16
REAC REAC:R-HSA-5621480 Dectin-2 family 0.0181935500314374 26 126 4 0.0317460317460317 0.153846153846154
REAC REAC:R-HSA-2172127 DAP12 interactions 0.0293869512948386 33 126 4 0.0317460317460317 0.121212121212121
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.0293869512948386 800 60 13 0.216666666666667 0.01625
REAC REAC:R-HSA-2454202 Fc epsilon receptor (FCERI) signaling 0.0293869512948386 182 22 4 0.181818181818182 0.021978021978022
REAC REAC:R-HSA-114604 GPVI-mediated activation cascade 0.0315769944700963 35 126 4 0.0317460317460317 0.114285714285714
REAC REAC:R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade 0.0324178348318898 97 24 3 0.125 0.0309278350515464
REAC REAC:R-HSA-2871796 FCERI mediated MAPK activation 0.0324178348318898 83 60 4 0.0666666666666667 0.0481927710843374
REAC REAC:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.0324178348318898 140 60 5 0.0833333333333333 0.0357142857142857
REAC REAC:R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade 0.0324178348318898 94 24 3 0.125 0.0319148936170213
REAC REAC:R-HSA-2022854 Keratan sulfate biosynthesis 0.0324178348318898 28 81 3 0.037037037037037 0.107142857142857
REAC REAC:R-HSA-182971 EGFR downregulation 0.0324178348318898 30 69 3 0.0434782608695652 0.1
REAC REAC:R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade 0.0324178348318898 97 24 3 0.125 0.0309278350515464
REAC REAC:R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 0.0324178348318898 94 24 3 0.125 0.0319148936170213
REAC REAC:R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.0377363682883491 93 60 4 0.0666666666666667 0.043010752688172
REAC REAC:R-HSA-9664417 Leishmania phagocytosis 0.0382562186904379 113 52 4 0.0769230769230769 0.0353982300884956
REAC REAC:R-HSA-9664422 FCGR3A-mediated phagocytosis 0.0382562186904379 113 52 4 0.0769230769230769 0.0353982300884956
REAC REAC:R-HSA-9664407 Parasite infection 0.0382562186904379 113 52 4 0.0769230769230769 0.0353982300884956
REAC REAC:R-HSA-1638074 Keratan sulfate/keratin metabolism 0.0382562186904379 34 81 3 0.037037037037037 0.0882352941176471
REAC REAC:R-HSA-1433557 Signaling by SCF-KIT 0.0382562186904379 38 71 3 0.0422535211267606 0.0789473684210526
REAC REAC:R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 0.0443490680806679 126 24 3 0.125 0.0238095238095238
REAC REAC:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.0493580733236093 485 79 10 0.126582278481013 0.0206185567010309
WP WP:WP4559 Interactions between immune cells and microRNAs in tumor microenvironment 0.0146030802605239 40 19 3 0.157894736842105 0.075
WP WP:WP69 T-Cell antigen Receptor (TCR) Signaling Pathway 0.0146030802605239 91 24 4 0.166666666666667 0.043956043956044
WP WP:WP304 Kit receptor signaling pathway 0.0361106087551132 60 21 3 0.142857142857143 0.05

pTNI08 transcription factor target enrichment of top program genes

TF enrichment of pTNI08
TFs corrosponding to activation of pTNI08. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.