pEpiTd05 program activity among Epithelial cells

Activation of pEpiTd05
pEpiTd05 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd05 by different cell subtypes
pEpiTd05 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd05 top program genes

Top genes of pEpiTd05 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd05 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd05
pEpiTd05 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:1990169 stress response to copper ion 1.0980302582729e-22 14 9 8 0.888888888888889 0.571428571428571
GO:BP GO:0010273 detoxification of copper ion 1.0980302582729e-22 14 9 8 0.888888888888889 0.571428571428571
GO:BP GO:0097501 stress response to metal ion 2.35269092537218e-22 16 9 8 0.888888888888889 0.5
GO:BP GO:0061687 detoxification of inorganic compound 2.35269092537218e-22 16 9 8 0.888888888888889 0.5
GO:BP GO:0071294 cellular response to zinc ion 7.16805459090671e-21 23 9 8 0.888888888888889 0.347826086956522
GO:BP GO:0071280 cellular response to copper ion 2.70413313092275e-20 27 9 8 0.888888888888889 0.296296296296296
GO:BP GO:0071276 cellular response to cadmium ion 3.52521645635783e-19 37 9 8 0.888888888888889 0.216216216216216
GO:BP GO:0006882 cellular zinc ion homeostasis 3.52521645635783e-19 37 9 8 0.888888888888889 0.216216216216216
GO:BP GO:0055069 zinc ion homeostasis 4.99293397921096e-19 39 9 8 0.888888888888889 0.205128205128205
GO:BP GO:0046688 response to copper ion 8.61954976267895e-19 42 9 8 0.888888888888889 0.19047619047619
GO:BP GO:0010043 response to zinc ion 8.07818444657768e-18 55 9 8 0.888888888888889 0.145454545454545
GO:BP GO:0046686 response to cadmium ion 3.06820930662305e-17 65 9 8 0.888888888888889 0.123076923076923
GO:BP GO:0046916 cellular transition metal ion homeostasis 3.55585390372945e-15 116 9 8 0.888888888888889 0.0689655172413793
GO:BP GO:0098754 detoxification 1.0819878996753e-14 134 9 8 0.888888888888889 0.0597014925373134
GO:BP GO:0055076 transition metal ion homeostasis 1.28557952928889e-14 138 9 8 0.888888888888889 0.0579710144927536
GO:BP GO:0071248 cellular response to metal ion 1.79007105044775e-13 192 9 8 0.888888888888889 0.0416666666666667
GO:BP GO:0071241 cellular response to inorganic substance 5.09533875006682e-13 220 9 8 0.888888888888889 0.0363636363636364
GO:BP GO:0009636 response to toxic substance 1.07812782826154e-12 243 9 8 0.888888888888889 0.0329218106995885
GO:BP GO:0045926 negative regulation of growth 1.50940183433095e-12 255 9 8 0.888888888888889 0.0313725490196078
GO:BP GO:0010038 response to metal ion 2.96380448761744e-11 371 9 8 0.888888888888889 0.0215633423180593
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 2.96609773664479e-10 497 9 8 0.888888888888889 0.0160965794768612
GO:BP GO:0072507 divalent inorganic cation homeostasis 3.82669021192326e-10 516 9 8 0.888888888888889 0.0155038759689922
GO:BP GO:0010035 response to inorganic substance 8.72593655114237e-10 575 9 8 0.888888888888889 0.0139130434782609
GO:BP GO:0006875 cellular metal ion homeostasis 1.07072031188625e-09 593 9 8 0.888888888888889 0.0134907251264755
GO:BP GO:0055065 metal ion homeostasis 2.63743985123662e-09 667 9 8 0.888888888888889 0.0119940029985007
GO:BP GO:0030003 cellular cation homeostasis 2.72454902193041e-09 673 9 8 0.888888888888889 0.011887072808321
GO:BP GO:0040008 regulation of growth 2.88401890388228e-09 681 9 8 0.888888888888889 0.0117474302496329
GO:BP GO:0006873 cellular ion homeostasis 2.98335986317901e-09 687 9 8 0.888888888888889 0.0116448326055313
GO:BP GO:0055080 cation homeostasis 5.81309794375943e-09 750 9 8 0.888888888888889 0.0106666666666667
GO:BP GO:0098771 inorganic ion homeostasis 6.31341055008896e-09 761 9 8 0.888888888888889 0.0105124835742444
GO:BP GO:0050801 ion homeostasis 9.86577163762158e-09 808 9 8 0.888888888888889 0.0099009900990099
GO:BP GO:0055082 cellular chemical homeostasis 1.31607654793979e-08 841 9 8 0.888888888888889 0.00951248513674197
GO:BP GO:0040007 growth 3.89086359076173e-08 967 9 8 0.888888888888889 0.00827300930713547
GO:BP GO:0019725 cellular homeostasis 4.23534100205434e-08 981 9 8 0.888888888888889 0.00815494393476045
GO:BP GO:0048878 chemical homeostasis 2.47906217014312e-07 1229 9 8 0.888888888888889 0.0065093572009764
GO:BP GO:0042592 homeostatic process 1.06435243298365e-05 1981 9 8 0.888888888888889 0.00403836446239273
GO:BP GO:0070887 cellular response to chemical stimulus 0.000481620611141291 3393 7 7 1 0.00206307102858827
GO:BP GO:0048519 negative regulation of biological process 0.000609810150348889 5757 10 10 1 0.00173701580684384
GO:BP GO:0006950 response to stress 0.000814002756391268 4170 10 9 0.9 0.00215827338129496
GO:BP GO:0065008 regulation of biological quality 0.00177541745878382 4131 7 7 1 0.00169450496247882
GO:BP GO:0042221 response to chemical 0.0048264366381546 4781 7 7 1 0.00146412884333821
GO:BP GO:0044282 small molecule catabolic process 0.0215458952134514 439 27 5 0.185185185185185 0.0113895216400911
GO:CC GO:0005634 nucleus 0.00380304635310164 7592 12 12 1 0.00158061116965227
GO:MF GO:0008270 zinc ion binding 4.45877023108131e-08 833 9 8 0.888888888888889 0.00960384153661465
GO:MF GO:0046914 transition metal ion binding 2.22015952224504e-07 1111 9 8 0.888888888888889 0.0072007200720072
GO:MF GO:0043169 cation binding 0.00315461736033456 4351 7 7 1 0.00160882555734314
GO:MF GO:0046872 metal ion binding 0.00315461736033456 4260 7 7 1 0.00164319248826291
GO:MF GO:0043167 ion binding 0.025603951751499 6057 7 7 1 0.00115568763414231
KEGG KEGG:04978 Mineral absorption 4.35069296777924e-15 59 9 8 0.888888888888889 0.135593220338983
REAC REAC:R-HSA-5661231 Metallothioneins bind metals 9.08215750209678e-23 11 9 8 0.888888888888889 0.727272727272727
REAC REAC:R-HSA-5660526 Response to metal ions 8.26267078310273e-22 14 9 8 0.888888888888889 0.571428571428571
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 2.43740209084344e-10 560 9 9 1 0.0160714285714286
TF TF:M00650_1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 2.15476647676601e-10 24 7 5 0.714285714285714 0.208333333333333
TF TF:M00650 Factor: MTF-1; motif: TBTGCACHCGGCCC 6.08418814158625e-07 816 7 7 1 0.00857843137254902
TF TF:M01119_1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 1 1.62078915759708e-06 542 26 10 0.384615384615385 0.018450184501845
TF TF:M08890 Factor: MYB; motif: NNAACTGN 2.42192568598833e-06 1355 11 9 0.818181818181818 0.00664206642066421
TF TF:M10163 Factor: ZNF708; motif: GNNNAANAARNAGGYACAGC 3.99832909068268e-06 219 7 5 0.714285714285714 0.0228310502283105
TF TF:M09813_1 Factor: MYB; motif: NNCAACTGNN; match class: 1 0.000201644490901043 979 11 7 0.636363636363636 0.00715015321756895
TF TF:M10085 Factor: RBPJK; motif: NSNSTGGGAAN 0.000209692388829957 3436 13 11 0.846153846153846 0.00320139697322468
TF TF:M04619_1 Factor: MTF-1; motif: CCGNGTGCAV; match class: 1 0.000229103529976073 50 6 3 0.5 0.06
TF TF:M10012 Factor: Rev-ErbAalpha; motif: NRNNMASTGGGTCANNNNN 0.000307227785219277 1105 11 7 0.636363636363636 0.00633484162895928
TF TF:M07341_1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 0.000555275527622316 884 14 7 0.5 0.00791855203619909
TF TF:M08890_1 Factor: MYB; motif: NNAACTGN; match class: 1 0.00140608777101912 63 9 3 0.333333333333333 0.0476190476190476
TF TF:M04903_1 Factor: HNF-4alpha; motif: AGTCCAAR; match class: 1 0.00212356215734084 1534 11 7 0.636363636363636 0.0045632333767927
TF TF:M02088 Factor: E2A; motif: NRMCASCTGCNNN 0.00315623392380963 2871 10 8 0.8 0.00278648554510623
TF TF:M07387_1 Factor: LRF; motif: NGKGGGTSNCN; match class: 1 0.00324712113511046 1040 95 17 0.178947368421053 0.0163461538461538
TF TF:M11344 Factor: MafF; motif: NTGCTGASTCAGCAN 0.00324712113511046 278 4 3 0.75 0.0107913669064748
TF TF:M11344_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.00324712113511046 268 4 3 0.75 0.0111940298507463
TF TF:M04218 Factor: MAFK; motif: NTGCTGANTCAGCRN 0.00324712113511046 261 4 3 0.75 0.0114942528735632
TF TF:M04721 Factor: STAT1; motif: NTTCCNGGA 0.00324712113511046 7847 22 19 0.863636363636364 0.00242130750605327
TF TF:M04903 Factor: HNF-4alpha; motif: AGTCCAAR 0.00324712113511046 6987 11 11 1 0.0015743523686847
TF TF:M02070 Factor: TEL1; motif: CNCGGAANNN 0.00324712113511046 10837 40 35 0.875 0.00322967610962443
TF TF:M07299 Factor: c-Myb; motif: NNNNCMGTTNNN 0.00324712113511046 3767 7 7 1 0.00185824263339527
TF TF:M09990_1 Factor: c-Myb; motif: NNWGRCAGTTRN; match class: 1 0.00341140112852814 3933 7 7 1 0.00177981184846173
TF TF:M04619 Factor: MTF-1; motif: CCGNGTGCAV 0.00352039691645932 1167 7 5 0.714285714285714 0.00428449014567267
TF TF:M11346_1 Factor: MafG; motif: NTGCTGASTCAGCAN; match class: 1 0.00352039691645932 302 4 3 0.75 0.00993377483443709
TF TF:M11346 Factor: MafG; motif: NTGCTGASTCAGCAN 0.00409585678564545 322 4 3 0.75 0.0093167701863354
TF TF:M11058_1 Factor: Hey1; motif: NGCRCGYGYN; match class: 1 0.00922938814147993 10925 82 63 0.768292682926829 0.00576659038901602
TF TF:M12280_1 Factor: MTF-1; motif: NTTTTGCACACGGCNNN; match class: 1 0.00922938814147993 1485 7 5 0.714285714285714 0.00336700336700337
TF TF:M11899 Factor: Oct-2; motif: NTGCATATGCAN 0.00922938814147993 5597 13 11 0.846153846153846 0.0019653385742362
TF TF:M07387 Factor: LRF; motif: NGKGGGTSNCN 0.00922938814147993 5232 77 37 0.480519480519481 0.00707186544342508
TF TF:M11899_1 Factor: Oct-2; motif: NTGCATATGCAN; match class: 1 0.0100497611207666 4493 9 8 0.888888888888889 0.0017805475183619
TF TF:M11365_1 Factor: MafA; motif: NYGCTGASTCAGCRN; match class: 1 0.0100497611207666 467 4 3 0.75 0.00642398286937901
TF TF:M11811 Factor: PPARdelta; motif: NRRGGTCGYGACCYYN 0.0101380690249771 403 34 6 0.176470588235294 0.0148883374689826
TF TF:M07341 Factor: TORC2; motif: TGGGCTKKD 0.0101380690249771 4887 7 7 1 0.00143237159811745
TF TF:M08674_1 Factor: AP-4:Max; motif: NCAGCTGNNNNNNNCACGTGN; match class: 1 0.0101380690249771 5667 15 12 0.8 0.00211752249867655
TF TF:M11365 Factor: MafA; motif: NYGCTGASTCAGCRN 0.0109965437488566 506 4 3 0.75 0.00592885375494071
TF TF:M11340_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.0114268585799061 525 4 3 0.75 0.00571428571428571
TF TF:M12280 Factor: MTF-1; motif: NTTTTGCACACGGCNNN 0.0114268585799061 6897 9 9 1 0.00130491518051327
TF TF:M07299_1 Factor: c-Myb; motif: NNNNCMGTTNNN; match class: 1 0.0114268585799061 450 11 4 0.363636363636364 0.00888888888888889
TF TF:M06617 Factor: ZNF480; motif: NGTGACCRGGGM 0.0114268585799061 48 34 3 0.0882352941176471 0.0625
TF TF:M04849 Factor: RelA-p65; motif: AAASTCCC 0.0114268585799061 6240 34 22 0.647058823529412 0.00352564102564103
TF TF:M01201_1 Factor: AR; motif: GGNACRNNRTGTWCT; match class: 1 0.0117212586826871 2129 12 7 0.583333333333333 0.00328792860497886
TF TF:M11368_1 Factor: MafA; motif: NTGCTGASTCAGCAN; match class: 1 0.0128377802764805 566 4 3 0.75 0.00530035335689046
TF TF:M11368 Factor: MafA; motif: NTGCTGASTCAGCAN 0.0128377802764805 570 4 3 0.75 0.00526315789473684
TF TF:M11274 Factor: XBP-1; motif: NGMCACRTCAYC 0.0132057520804754 1759 7 5 0.714285714285714 0.00284252416145537
TF TF:M11340 Factor: MafF; motif: NTGCTGASTCAGCAN 0.0132057520804754 580 4 3 0.75 0.00517241379310345
TF TF:M01859 Factor: AP-2; motif: NNGCCTK 0.0134084510319519 7799 16 14 0.875 0.00179510193614566
TF TF:M11779 Factor: RXR-gamma; motif: RRGGTCAYGACCYY 0.0134084510319519 54 34 3 0.0882352941176471 0.0555555555555556
TF TF:M00156 Factor: RORalpha1; motif: NWAWNNAGGTCAN 0.0134084510319519 255 37 5 0.135135135135135 0.0196078431372549
TF TF:M11849_1 Factor: MR; motif: NGNACRNNNYGTNCN; match class: 1 0.0141994809110644 4264 12 9 0.75 0.00211069418386492
TF TF:M08289 Factor: Fli-1:Max; motif: NCCGGAAACACGTGN 0.0141994809110644 9971 31 26 0.838709677419355 0.00260756192959583
TF TF:M06099 Factor: ZNF14; motif: GTTGTAAAGA 0.0146015381382932 242 22 4 0.181818181818182 0.0165289256198347
TF TF:M04721_1 Factor: STAT1; motif: NTTCCNGGA; match class: 1 0.0146015381382932 2635 45 16 0.355555555555556 0.00607210626185958
TF TF:M09813 Factor: MYB; motif: NNCAACTGNN 0.0146015381382932 5545 7 7 1 0.00126239855725879
TF TF:M11849 Factor: MR; motif: NGNACRNNNYGTNCN 0.0146015381382932 4324 12 9 0.75 0.00208140610545791
TF TF:M00481_1 Factor: AR; motif: GGTACANNRTGTTCT; match class: 1 0.0146015381382932 2295 12 7 0.583333333333333 0.00305010893246187
TF TF:M04818 Factor: IRF-4; motif: RGGAASWGR 0.0146015381382932 9372 12 12 1 0.00128040973111396
TF TF:M08952 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN 0.0166177518082715 7763 107 61 0.570093457943925 0.00785778693803942
TF TF:M09725 Factor: DREF; motif: CTYYCWCTTCCY 0.0172800541462284 7519 9 9 1 0.00119696768187259
TF TF:M04636_1 Factor: TFII-I; motif: NAGGAAGTGN; match class: 1 0.0175201947293722 5733 7 7 1 0.00122100122100122
TF TF:M00088 Factor: Ik-3; motif: TNYTGGGAATACC 0.017852849423495 5762 7 7 1 0.00121485595279417
TF TF:M00192 Factor: GR; motif: NNNNNNCNNTNTGTNCTNN 0.0183470104644095 7611 9 9 1 0.00118249901458415
TF TF:M00631 Factor: FXR:RXR-alpha; motif: CAAGGTSAWTAACC 0.0188639499991027 3541 7 6 0.857142857142857 0.00169443659983056
TF TF:M01884_1 Factor: IRF-7; motif: AAGWGAA; match class: 1 0.0206503546842467 4556 8 7 0.875 0.00153643546971027
TF TF:M11276 Factor: XBP-1; motif: NNMCACGTCANN 0.0213642089992418 551 21 5 0.238095238095238 0.00907441016333938
TF TF:M04453_1 Factor: AR; motif: RGGWACAYNGTGTWCYN; match class: 1 0.0217048194650212 3794 9 7 0.777777777777778 0.0018450184501845
TF TF:M11739 Factor: COUP-TF1; motif: RRGGTCRNTGACCTN 0.022434138346973 2698 6 5 0.833333333333333 0.00185322461082283
TF TF:M00483 Factor: ATF6; motif: TGACGTGG 0.022434138346973 2627 26 11 0.423076923076923 0.00418728587742672
TF TF:M04926 Factor: REST; motif: AAGGTGCT 0.0282720681684908 6325 7 7 1 0.00110671936758893
TF TF:M08289_1 Factor: Fli-1:Max; motif: NCCGGAAACACGTGN; match class: 1 0.0282720681684908 3329 43 17 0.395348837209302 0.00510663863021928
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0282720681684908 9106 99 63 0.636363636363636 0.00691851526466066
TF TF:M11066 Factor: HES-7; motif: GNCACGYGNN 0.0282720681684908 11507 79 61 0.772151898734177 0.00530112105674807
TF TF:M09895 Factor: E2F-6; motif: NGGGCGGGARRNN 0.0285693420620755 7765 48 31 0.645833333333333 0.00399227301996137
TF TF:M04715 Factor: Oct-2; motif: ATTTGCA 0.0292809978867396 6381 7 7 1 0.00109700673875568
TF TF:M11888 Factor: Pax-4a; motif: NTYACGCWTSANYGCNYN 0.0296724771708062 753 85 11 0.129411764705882 0.0146082337317397
TF TF:M10051 Factor: RORgamma; motif: NNAASTRGGTCA 0.0310861933726964 1550 14 6 0.428571428571429 0.00387096774193548
TF TF:M01119 Factor: Kaiso; motif: NTCCTGCNAN 0.0315255939624773 4264 11 8 0.727272727272727 0.00187617260787992
TF TF:M12279 Factor: MTF-1; motif: NTTTTGCACACGGCNYN 0.0318552233543614 6713 10 9 0.9 0.00134068225830478
TF TF:M08961 Factor: PPARGAMMA; motif: NWNTRGGTYANN 0.0323579187809286 5433 6 6 1 0.00110436223081171
TF TF:M11052_1 Factor: Hey2; motif: NNCACGYGNN; match class: 1 0.0327231948224172 9523 82 55 0.670731707317073 0.00577549091672792
TF TF:M08224 Factor: Elk-1:Pax-1; motif: ACCGGAACTACGCWTSANTG 0.0333748801055977 8925 35 26 0.742857142857143 0.00291316526610644
TF TF:M00194 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN 0.0333748801055977 2412 7 5 0.714285714285714 0.00207296849087894
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.033696302760145 11063 79 59 0.746835443037975 0.00533309228961403
TF TF:M09941_1 Factor: GR; motif: RGNACANMNTGTNCY; match class: 1 0.0357399832335917 2046 8 5 0.625 0.00244379276637341
TF TF:M08266_1 Factor: ER71:Pax-5; motif: ACCGGAACYACGCWTSANTG; match class: 1 0.0361744517817787 8979 35 26 0.742857142857143 0.00289564539481011
TF TF:M09892_1 Factor: E2F-1; motif: NNNNGGCGGGAARN; match class: 1 0.0364791088543245 9162 48 34 0.708333333333333 0.00371098013534163
TF TF:M11765_1 Factor: TR2; motif: NRGGTCRYGACCYN; match class: 1 0.0364791088543245 1431 34 9 0.264705882352941 0.00628930817610063
TF TF:M12324 Factor: ZBTB12; motif: TGGCCTGNCGTCGY 0.0364791088543245 93 34 3 0.0882352941176471 0.032258064516129
TF TF:M00468_1 Factor: AP-2rep; motif: CAGTGGG; match class: 1 0.0391500595392837 1686 24 8 0.333333333333333 0.00474495848161329
TF TF:M11741 Factor: COUP-TF1; motif: RRGGTCRNTGACCYY 0.0409260094458813 3249 6 5 0.833333333333333 0.0015389350569406
TF TF:M03902 Factor: GLI2; motif: GCGACCACMCTR 0.0412176006210519 1567 106 19 0.179245283018868 0.0121250797702616
TF TF:M09589_1 Factor: AR; motif: NGNACANNNTGTTCYNN; match class: 1 0.0438599614571328 1159 8 4 0.5 0.00345125107851596
TF TF:M00224 Factor: STAT1; motif: NNNSANTTCCGGGAANTGNSN 0.0453011841323629 5609 34 19 0.558823529411765 0.00338741308611161
TF TF:M00447_1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 1 0.0469400003353634 854 5 3 0.6 0.00351288056206089
TF TF:M11763_1 Factor: TR2; motif: RRGGTCRYGACCYY; match class: 1 0.0469400003353634 241 34 4 0.117647058823529 0.016597510373444
TF TF:M01100_1 Factor: LRF; motif: GGGGKYNNB; match class: 1 0.0488189409798721 2762 88 24 0.272727272727273 0.00868935553946416
TF TF:M11803_1 Factor: NR1B2; motif: RAGGTCATGACCTN; match class: 1 0.0491588262616134 915 34 7 0.205882352941176 0.00765027322404372
TF TF:M04015_1 Factor: IRF-4; motif: NCGAAACCGAAACYA; match class: 1 0.0497219574952075 158 91 5 0.0549450549450549 0.0316455696202532
TF TF:M08458 Factor: Erm:C/EBPdelta; motif: RSCGGAWRTTGCGYAAY 0.0498805061861483 9714 10 10 1 0.00102944204241301
WP WP:WP3529 Zinc homeostasis 1.34878162525692e-16 37 9 8 0.888888888888889 0.216216216216216
WP WP:WP3286 Copper homeostasis 1.16278928697152e-12 54 9 7 0.777777777777778 0.12962962962963

pEpiTd05 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd05
Possible regulators of activation of pEpiTd05 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.