pEpiTp06 program activity among Epithelial cells

Activation of pEpiTp06
pEpiTp06 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp06 by different cell subtypes
pEpiTp06 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp06 top program genes

Top genes of pEpiTp06 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp06 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp06
pEpiTp06 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:306 Ribosome, cytoplasmic 2.68482733935e-08 80 12 7 0.583333333333333 0.0875
CORUM CORUM:305 40S ribosomal subunit, cytoplasmic 2.4561026330321e-06 33 8 4 0.5 0.121212121212121
CORUM CORUM:338 40S ribosomal subunit, cytoplasmic 2.4561026330321e-06 31 8 4 0.5 0.129032258064516
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 0.00196427857105386 47 12 3 0.25 0.0638297872340425
CORUM CORUM:3055 Nop56p-associated pre-rRNA complex 0.0132146238151456 104 12 3 0.25 0.0288461538461538
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 6.22566919668953e-11 96 12 7 0.583333333333333 0.0729166666666667
GO:BP GO:0006613 cotranslational protein targeting to membrane 6.22566919668953e-11 102 12 7 0.583333333333333 0.0686274509803922
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 8.3294248834572e-11 117 12 7 0.583333333333333 0.0598290598290598
GO:BP GO:0045047 protein targeting to ER 8.3294248834572e-11 113 12 7 0.583333333333333 0.0619469026548673
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 9.52911590007933e-11 123 12 7 0.583333333333333 0.0569105691056911
GO:BP GO:0070972 protein localization to endoplasmic reticulum 2.6955819560524e-10 146 12 7 0.583333333333333 0.0479452054794521
GO:BP GO:0019083 viral transcription 1.06096327732714e-09 181 12 7 0.583333333333333 0.0386740331491713
GO:BP GO:0006518 peptide metabolic process 1.31133702234248e-09 955 12 10 0.833333333333333 0.0104712041884817
GO:BP GO:0019080 viral gene expression 1.55752627810626e-09 199 12 7 0.583333333333333 0.0351758793969849
GO:BP GO:0006413 translational initiation 1.55752627810626e-09 201 12 7 0.583333333333333 0.0348258706467662
GO:BP GO:0006612 protein targeting to membrane 1.57197550979486e-09 204 12 7 0.583333333333333 0.0343137254901961
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 2.01937506783146e-09 214 12 7 0.583333333333333 0.0327102803738318
GO:BP GO:0043603 cellular amide metabolic process 1.08668179033033e-08 1241 12 10 0.833333333333333 0.008058017727639
GO:BP GO:0042773 ATP synthesis coupled electron transport 3.1519142043976e-08 100 18 6 0.333333333333333 0.06
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 3.1519142043976e-08 99 18 6 0.333333333333333 0.0606060606060606
GO:BP GO:0090150 establishment of protein localization to membrane 4.86279407441298e-08 351 12 7 0.583333333333333 0.0199430199430199
GO:BP GO:0022904 respiratory electron transport chain 7.22640136504255e-08 117 18 6 0.333333333333333 0.0512820512820513
GO:BP GO:0006402 mRNA catabolic process 8.08429000746505e-08 384 12 7 0.583333333333333 0.0182291666666667
GO:BP GO:0006401 RNA catabolic process 1.52543777332634e-07 424 12 7 0.583333333333333 0.0165094339622642
GO:BP GO:0006605 protein targeting 1.90390865268601e-07 441 12 7 0.583333333333333 0.0158730158730159
GO:BP GO:0006412 translation 2.16397801114447e-07 764 12 8 0.666666666666667 0.0104712041884817
GO:BP GO:0043043 peptide biosynthetic process 2.5718211884959e-07 790 12 8 0.666666666666667 0.010126582278481
GO:BP GO:0006119 oxidative phosphorylation 2.5718211884959e-07 151 18 6 0.333333333333333 0.0397350993377483
GO:BP GO:0016071 mRNA metabolic process 5.45591558836924e-07 874 12 8 0.666666666666667 0.0091533180778032
GO:BP GO:0022900 electron transport chain 6.58163394208982e-07 180 18 6 0.333333333333333 0.0333333333333333
GO:BP GO:0043604 amide biosynthetic process 8.02893055210902e-07 932 12 8 0.666666666666667 0.00858369098712446
GO:BP GO:0034655 nucleobase-containing compound catabolic process 8.02893055210902e-07 567 12 7 0.583333333333333 0.0123456790123457
GO:BP GO:0045333 cellular respiration 8.64202705733358e-07 192 18 6 0.333333333333333 0.03125
GO:BP GO:0072594 establishment of protein localization to organelle 9.15906013279652e-07 584 12 7 0.583333333333333 0.011986301369863
GO:BP GO:1901566 organonitrogen compound biosynthetic process 9.66068161577204e-07 1853 13 10 0.769230769230769 0.00539665407447383
GO:BP GO:0046700 heterocycle catabolic process 1.05609532459177e-06 602 12 7 0.583333333333333 0.0116279069767442
GO:BP GO:0044270 cellular nitrogen compound catabolic process 1.09538808676788e-06 608 12 7 0.583333333333333 0.0115131578947368
GO:BP GO:0019439 aromatic compound catabolic process 1.25614770037714e-06 623 12 7 0.583333333333333 0.0112359550561798
GO:BP GO:1901361 organic cyclic compound catabolic process 1.64943941814561e-06 651 12 7 0.583333333333333 0.010752688172043
GO:BP GO:0072657 protein localization to membrane 1.85445075296491e-06 665 12 7 0.583333333333333 0.0105263157894737
GO:BP GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c 4.01454122719336e-06 13 15 3 0.2 0.230769230769231
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 7.3890361741807e-06 289 18 6 0.333333333333333 0.0207612456747405
GO:BP GO:0046034 ATP metabolic process 1.17159952703782e-05 314 18 6 0.333333333333333 0.0191082802547771
GO:BP GO:0016032 viral process 1.78032163899676e-05 942 12 7 0.583333333333333 0.00743099787685775
GO:BP GO:0010629 negative regulation of gene expression 1.78032163899676e-05 1460 12 8 0.666666666666667 0.00547945205479452
GO:BP GO:0044403 biological process involved in symbiotic interaction 2.57510814707639e-05 1001 12 7 0.583333333333333 0.00699300699300699
GO:BP GO:0033365 protein localization to organelle 2.79849120573761e-05 1017 12 7 0.583333333333333 0.00688298918387414
GO:BP GO:0051649 establishment of localization in cell 3.75218147080797e-05 2813 13 10 0.769230769230769 0.00355492356914326
GO:BP GO:0006886 intracellular protein transport 7.52831624180982e-05 1186 12 7 0.583333333333333 0.00590219224283305
GO:BP GO:0044265 cellular macromolecule catabolic process 9.4502241694058e-05 1231 12 7 0.583333333333333 0.00568643379366369
GO:BP GO:0055114 obsolete oxidation-reduction process 9.94259516558432e-05 745 18 7 0.388888888888889 0.00939597315436242
GO:BP GO:0046907 intracellular transport 0.000155815051747738 1767 13 8 0.615384615384615 0.00452744765138653
GO:BP GO:0006811 ion transport 0.000166811761102459 3661 19 13 0.684210526315789 0.00355094236547391
GO:BP GO:0006091 generation of precursor metabolites and energy 0.000201983147825157 538 18 6 0.333333333333333 0.0111524163568773
GO:BP GO:0009057 macromolecule catabolic process 0.000269832940827345 1468 12 7 0.583333333333333 0.00476839237057221
GO:BP GO:0051641 cellular localization 0.000273099572195632 3541 13 10 0.769230769230769 0.00282406099971759
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.000369244919719013 2255 12 8 0.666666666666667 0.00354767184035477
GO:BP GO:0002181 cytoplasmic translation 0.00076065024255781 103 12 3 0.25 0.029126213592233
GO:BP GO:0006810 transport 0.00114698014503606 5224 15 12 0.8 0.00229709035222052
GO:BP GO:0015031 protein transport 0.00142765040687911 1929 12 7 0.583333333333333 0.00362882322446864
GO:BP GO:0051234 establishment of localization 0.00150296006634746 5372 15 12 0.8 0.00223380491437081
GO:BP GO:0015833 peptide transport 0.00158727819754017 1971 12 7 0.583333333333333 0.00355149670218163
GO:BP GO:0009060 aerobic respiration 0.00160736472503703 89 18 3 0.166666666666667 0.0337078651685393
GO:BP GO:0042886 amide transport 0.00169991271735935 2007 12 7 0.583333333333333 0.00348779272546089
GO:BP GO:0034613 cellular protein localization 0.00171151520171982 2014 12 7 0.583333333333333 0.00347567030784508
GO:BP GO:0070727 cellular macromolecule localization 0.0017400986537227 2024 12 7 0.583333333333333 0.00345849802371542
GO:BP GO:0045184 establishment of protein localization 0.00177490799393952 2035 12 7 0.583333333333333 0.00343980343980344
GO:BP GO:1901575 organic substance catabolic process 0.00300861492174714 2267 12 7 0.583333333333333 0.00308778120864579
GO:BP GO:0071705 nitrogen compound transport 0.00346238746471566 2322 12 7 0.583333333333333 0.00301464254952627
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.00347769797195564 3241 12 8 0.666666666666667 0.00246837395865474
GO:BP GO:0044249 cellular biosynthetic process 0.00347769797195564 6154 13 11 0.846153846153846 0.00178745531361716
GO:BP GO:0044248 cellular catabolic process 0.00348653136083188 2347 12 7 0.583333333333333 0.00298253089049851
GO:BP GO:1901576 organic substance biosynthetic process 0.00379378402052664 6248 13 11 0.846153846153846 0.00176056338028169
GO:BP GO:0016310 phosphorylation 0.00403282505582875 2138 21 9 0.428571428571429 0.00420954162768943
GO:BP GO:0009058 biosynthetic process 0.00406860346850226 6340 13 11 0.846153846153846 0.00173501577287066
GO:BP GO:0009892 negative regulation of metabolic process 0.00484150561439633 3479 12 8 0.666666666666667 0.00229951135383731
GO:BP GO:1902600 proton transmembrane transport 0.00508416327992255 157 18 3 0.166666666666667 0.0191082802547771
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.00518328974870761 6563 13 11 0.846153846153846 0.00167606277616943
GO:BP GO:0006812 cation transport 0.00568257777533432 1197 30 8 0.266666666666667 0.00668337510442774
GO:BP GO:0046916 cellular transition metal ion homeostasis 0.00660403257841137 116 27 3 0.111111111111111 0.0258620689655172
GO:BP GO:1901564 organonitrogen compound metabolic process 0.0067474498532646 6792 13 11 0.846153846153846 0.00161955241460542
GO:BP GO:0009056 catabolic process 0.00689356992478788 2744 12 7 0.583333333333333 0.00255102040816327
GO:BP GO:0071702 organic substance transport 0.0071213631166148 2766 12 7 0.583333333333333 0.00253073029645698
GO:BP GO:0008104 protein localization 0.00712450226022675 2770 12 7 0.583333333333333 0.00252707581227437
GO:BP GO:0006979 response to oxidative stress 0.00738552180434086 466 17 4 0.235294117647059 0.00858369098712446
GO:BP GO:0010941 regulation of cell death 0.00787711417008015 1720 3 3 1 0.00174418604651163
GO:BP GO:0000041 transition metal ion transport 0.00805494666927752 129 27 3 0.111111111111111 0.0232558139534884
GO:BP GO:0006820 anion transport 0.00853806828989056 2889 12 7 0.583333333333333 0.00242298373139495
GO:BP GO:0009059 macromolecule biosynthetic process 0.00885423711102562 5114 12 9 0.75 0.00175987485334376
GO:BP GO:0051179 localization 0.00902817134634192 6901 15 12 0.8 0.0017388784234169
GO:BP GO:0055076 transition metal ion homeostasis 0.00902817134634192 138 27 3 0.111111111111111 0.0217391304347826
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.00902817134634192 3087 21 10 0.476190476190476 0.00323939099449304
GO:BP GO:0043434 response to peptide hormone 0.00922932002475991 462 19 4 0.210526315789474 0.00865800865800866
GO:BP GO:0006793 phosphorus metabolic process 0.00939681874500908 3114 21 10 0.476190476190476 0.00321130378933847
GO:BP GO:0044267 cellular protein metabolic process 0.00939681874500908 5229 12 9 0.75 0.00172117039586919
GO:BP GO:0033036 macromolecule localization 0.0129839258504053 3218 12 7 0.583333333333333 0.00217526413921691
GO:BP GO:0008219 cell death 0.0134752021503392 2292 3 3 1 0.00130890052356021
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0141971243763069 5017 13 9 0.692307692307692 0.00179390073749253
GO:BP GO:1901652 response to peptide 0.0144075626620971 551 19 4 0.210526315789474 0.00725952813067151
GO:BP GO:0044237 cellular metabolic process 0.0148847140459097 10871 21 19 0.904761904761905 0.00174776929445313
GO:BP GO:0048519 negative regulation of biological process 0.0158462310296062 5757 12 9 0.75 0.00156331422615946
GO:BP GO:0098662 inorganic cation transmembrane transport 0.0161819735777265 794 23 5 0.217391304347826 0.00629722921914358
GO:BP GO:0019538 protein metabolic process 0.0163632835594966 5808 12 9 0.75 0.0015495867768595
GO:BP GO:0098655 cation transmembrane transport 0.0186999274680629 914 30 6 0.2 0.00656455142231947
GO:BP GO:0016070 RNA metabolic process 0.0191830655875126 4710 12 8 0.666666666666667 0.00169851380042463
GO:BP GO:0098660 inorganic ion transmembrane transport 0.0216097822365052 883 23 5 0.217391304347826 0.00566251415628539
GO:BP GO:0010467 gene expression 0.0220649631738296 6179 12 9 0.75 0.00145654636672601
GO:BP GO:0010952 positive regulation of peptidase activity 0.0221593196119753 205 30 3 0.1 0.0146341463414634
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.0253310408698032 5051 12 8 0.666666666666667 0.00158384478321125
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0260369847131447 5746 13 9 0.692307692307692 0.00156630699617125
GO:BP GO:0031667 response to nutrient levels 0.027778533341739 482 15 3 0.2 0.00622406639004149
GO:BP GO:0098657 import into cell 0.027778533341739 235 30 3 0.1 0.0127659574468085
GO:BP GO:0010468 regulation of gene expression 0.0283737354095091 5196 12 8 0.666666666666667 0.00153964588144727
GO:BP GO:1901700 response to oxygen-containing compound 0.0283737354095091 1739 19 6 0.315789473684211 0.00345025876940771
GO:BP GO:0046483 heterocycle metabolic process 0.0290289279116251 5904 13 9 0.692307692307692 0.00152439024390244
GO:BP GO:0090304 nucleic acid metabolic process 0.0290289279116251 5226 12 8 0.666666666666667 0.00153080750095675
GO:BP GO:0009991 response to extracellular stimulus 0.0301171956868857 512 15 3 0.2 0.005859375
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.03011772516627 5956 13 9 0.692307692307692 0.00151108126259234
GO:BP GO:0006952 defense response 0.0320442173629582 1818 5 3 0.6 0.00165016501650165
GO:BP GO:0008152 metabolic process 0.0332083225232156 11827 21 19 0.904761904761905 0.00160649361630168
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0352477808509889 6201 13 9 0.692307692307692 0.00145137880986938
GO:BP GO:0048583 regulation of response to stimulus 0.0406971979541744 4278 3 3 1 0.000701262272089762
GO:BP GO:0009725 response to hormone 0.0418037596294557 921 19 4 0.210526315789474 0.00434310532030402
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0483375406242441 1107 17 4 0.235294117647059 0.003613369467028
GO:CC GO:0022626 cytosolic ribosome 2.7331216474966e-11 109 12 7 0.583333333333333 0.0642201834862385
GO:CC GO:0044391 ribosomal subunit 7.13797834801643e-10 190 12 7 0.583333333333333 0.0368421052631579
GO:CC GO:0005840 ribosome 2.85631086134672e-09 245 12 7 0.583333333333333 0.0285714285714286
GO:CC GO:0098803 respiratory chain complex 6.70785828689758e-09 86 18 6 0.333333333333333 0.0697674418604651
GO:CC GO:0070469 respirasome 1.61696409644717e-08 103 18 6 0.333333333333333 0.058252427184466
GO:CC GO:0022627 cytosolic small ribosomal subunit 7.94450616446974e-08 47 8 4 0.5 0.0851063829787234
GO:CC GO:0032991 protein-containing complex 3.11531720847137e-07 5548 18 17 0.944444444444444 0.00306416726748378
GO:CC GO:0005746 mitochondrial respirasome 3.11531720847137e-07 89 17 5 0.294117647058824 0.0561797752808989
GO:CC GO:0015935 small ribosomal subunit 3.59207873979845e-07 75 8 4 0.5 0.0533333333333333
GO:CC GO:0070069 cytochrome complex 5.36139743328012e-07 34 18 4 0.222222222222222 0.117647058823529
GO:CC GO:1990204 oxidoreductase complex 7.56506715530432e-07 113 17 5 0.294117647058824 0.0442477876106195
GO:CC GO:1990904 ribonucleoprotein complex 9.36802532161442e-07 688 12 7 0.583333333333333 0.0101744186046512
GO:CC GO:0005844 polysome 1.47221721477619e-06 72 12 4 0.333333333333333 0.0555555555555556
GO:CC GO:0045275 respiratory chain complex III 1.57361704171486e-06 13 15 3 0.2 0.230769230769231
GO:CC GO:0005750 mitochondrial respiratory chain complex III 1.57361704171486e-06 13 15 3 0.2 0.230769230769231
GO:CC GO:0098800 inner mitochondrial membrane protein complex 1.87829357686636e-06 146 17 5 0.294117647058824 0.0342465753424658
GO:CC GO:0005743 mitochondrial inner membrane 2.66793130248908e-06 503 18 7 0.388888888888889 0.0139165009940358
GO:CC GO:0019866 organelle inner membrane 5.46475955813727e-06 564 18 7 0.388888888888889 0.0124113475177305
GO:CC GO:0042788 polysomal ribosome 1.2489354719624e-05 34 12 3 0.25 0.0882352941176471
GO:CC GO:0098798 mitochondrial protein-containing complex 3.04537104445564e-05 270 17 5 0.294117647058824 0.0185185185185185
GO:CC GO:0031966 mitochondrial membrane 3.04537104445564e-05 746 18 7 0.388888888888889 0.00938337801608579
GO:CC GO:0005740 mitochondrial envelope 4.50474148573005e-05 797 18 7 0.388888888888889 0.00878293601003764
GO:CC GO:0022625 cytosolic large ribosomal subunit 5.00366734756255e-05 57 12 3 0.25 0.0526315789473684
GO:CC GO:0005739 mitochondrion 5.96683770200557e-05 1673 18 9 0.5 0.00537955768081291
GO:CC GO:0031975 envelope 5.96683770200557e-05 1237 18 8 0.444444444444444 0.00646725949878739
GO:CC GO:0005829 cytosol 5.96683770200557e-05 5303 12 11 0.916666666666667 0.00207429756741467
GO:CC GO:0031967 organelle envelope 5.96683770200557e-05 1237 18 8 0.444444444444444 0.00646725949878739
GO:CC GO:0015934 large ribosomal subunit 0.000366867599767047 118 12 3 0.25 0.0254237288135593
GO:CC GO:0070062 extracellular exosome 0.00096637245515444 2176 9 6 0.666666666666667 0.00275735294117647
GO:CC GO:0005737 cytoplasm 0.000969117853693666 11911 19 19 1 0.00159516413399379
GO:CC GO:0043230 extracellular organelle 0.0010973730319085 2263 9 6 0.666666666666667 0.00265134776844896
GO:CC GO:1903561 extracellular vesicle 0.0010973730319085 2261 9 6 0.666666666666667 0.00265369305616984
GO:CC GO:0005615 extracellular space 0.00133637917823633 3594 9 7 0.777777777777778 0.00194769059543684
GO:CC GO:0055038 recycling endosome membrane 0.00203899966853741 84 31 3 0.0967741935483871 0.0357142857142857
GO:CC GO:0014069 postsynaptic density 0.0033178827140852 334 10 3 0.3 0.00898203592814371
GO:CC GO:0032279 asymmetric synapse 0.00340265787470787 340 10 3 0.3 0.00882352941176471
GO:CC GO:0099572 postsynaptic specialization 0.00385265732794928 358 10 3 0.3 0.00837988826815642
GO:CC GO:0098984 neuron to neuron synapse 0.00400560997527598 366 10 3 0.3 0.00819672131147541
GO:CC GO:0098796 membrane protein complex 0.00447663890077657 1322 18 6 0.333333333333333 0.00453857791225416
GO:CC GO:0005576 extracellular region 0.00454181689052318 4567 9 7 0.777777777777778 0.00153273483687322
GO:CC GO:0045202 synapse 0.00488919151803199 1349 31 8 0.258064516129032 0.00593031875463306
GO:CC GO:0005730 nucleolus 0.00644330231178232 955 11 4 0.363636363636364 0.00418848167539267
GO:CC GO:0005925 focal adhesion 0.00644330231178232 420 11 3 0.272727272727273 0.00714285714285714
GO:CC GO:0030055 cell-substrate junction 0.00651154706475142 427 11 3 0.272727272727273 0.00702576112412178
GO:CC GO:0043226 organelle 0.00674972937496245 14008 21 21 1 0.00149914334665905
GO:CC GO:0043229 intracellular organelle 0.00708464285836181 12491 21 20 0.952380952380952 0.00160115283003763
GO:CC GO:0031982 vesicle 0.00965840547690775 4055 31 14 0.451612903225806 0.00345252774352651
GO:CC GO:0055037 recycling endosome 0.0127677465725947 188 31 3 0.0967741935483871 0.0159574468085106
GO:CC GO:0031974 membrane-enclosed lumen 0.0128862587789507 5565 11 8 0.727272727272727 0.00143755615453729
GO:CC GO:0043233 organelle lumen 0.0128862587789507 5565 11 8 0.727272727272727 0.00143755615453729
GO:CC GO:0031090 organelle membrane 0.0128862587789507 3612 25 11 0.44 0.00304540420819491
GO:CC GO:0098794 postsynapse 0.0129945755645909 639 10 3 0.3 0.00469483568075117
GO:CC GO:0005622 intracellular anatomical structure 0.0177827577012632 14790 21 21 1 0.00141987829614604
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.0199832994385545 5338 12 8 0.666666666666667 0.0014986886474335
GO:CC GO:0043228 non-membrane-bounded organelle 0.0199832994385545 5346 12 8 0.666666666666667 0.00149644594089039
GO:CC GO:1902494 catalytic complex 0.022219212758509 1441 17 5 0.294117647058824 0.00346981263011797
GO:CC GO:0005634 nucleus 0.0246279618398388 7592 8 7 0.875 0.000922023182297155
GO:CC GO:0070161 anchoring junction 0.0246279618398388 836 19 4 0.210526315789474 0.00478468899521531
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0246279618398388 11296 25 21 0.84 0.00185906515580737
GO:CC GO:0098793 presynapse 0.0264784892721312 521 31 4 0.129032258064516 0.00767754318618042
GO:CC GO:0043227 membrane-bounded organelle 0.0293367319793961 12858 27 24 0.888888888888889 0.00186654223051797
GO:CC GO:0005654 nucleoplasm 0.0356677907036528 4102 8 5 0.625 0.00121891760117016
GO:CC GO:0016020 membrane 0.0356677907036528 9838 19 15 0.789473684210526 0.00152470014230535
GO:CC GO:0012505 endomembrane system 0.0356677907036528 4640 3 3 1 0.000646551724137931
GO:CC GO:0070013 intracellular organelle lumen 0.0383561319730781 5402 11 7 0.636363636363636 0.00129581636430952
GO:CC GO:0030054 cell junction 0.0407783048253701 2105 31 8 0.258064516129032 0.00380047505938242
GO:CC GO:0031981 nuclear lumen 0.0476636563200013 4444 8 5 0.625 0.00112511251125113
GO:MF GO:0003735 structural constituent of ribosome 7.37766674280818e-10 171 12 7 0.583333333333333 0.0409356725146199
GO:MF GO:0005198 structural molecule activity 6.74766986687076e-06 698 12 7 0.583333333333333 0.0100286532951289
GO:MF GO:0009055 electron transfer activity 1.55815396385973e-05 148 18 5 0.277777777777778 0.0337837837837838
GO:MF GO:0003723 RNA binding 0.000154260679660292 1943 12 8 0.666666666666667 0.00411734431291817
GO:MF GO:0016491 oxidoreductase activity 0.000154260679660292 771 18 7 0.388888888888889 0.00907911802853437
GO:MF GO:0003676 nucleic acid binding 0.010544531825165 4276 12 8 0.666666666666667 0.00187090739008419
GO:MF GO:1901363 heterocyclic compound binding 0.0346228167967308 6228 13 9 0.692307692307692 0.00144508670520231
GO:MF GO:0097159 organic cyclic compound binding 0.0364822958443235 6309 13 9 0.692307692307692 0.0014265335235378
HPA HPA:0050053 breast; glandular cells[High] 0.0335632957269744 1299 18 9 0.5 0.0069284064665127
HPA HPA:0210053 fallopian tube; glandular cells[High] 0.0472767698694674 1728 13 8 0.615384615384615 0.00462962962962963
HPA HPA:0090942 cerebellum; Purkinje cells - cytoplasm/membrane[≥Medium] 0.0490113839732349 368 16 4 0.25 0.0108695652173913
HPA HPA:0030073 appendix; lymphoid tissue[High] 0.0490113839732349 803 7 4 0.571428571428571 0.0049813200498132
HPA HPA:0310433 lymph node; germinal center cells[High] 0.0490113839732349 908 7 4 0.571428571428571 0.00440528634361234
HPA HPA:0350473 pancreas; exocrine glandular cells[High] 0.0490113839732349 1879 18 9 0.5 0.00478978179882916
HPA HPA:0060102 bronchus; respiratory epithelial cells[≥Medium] 0.0490113839732349 5184 19 16 0.842105263157895 0.00308641975308642
HPA HPA:0360000 parathyroid gland 0.0490113839732349 5767 19 17 0.894736842105263 0.00294780648517427
HPA HPA:0360051 parathyroid gland; glandular cells[≥Low] 0.0490113839732349 5767 19 17 0.894736842105263 0.00294780648517427
HPA HPA:0420053 salivary gland; glandular cells[High] 0.0490113839732349 1418 18 8 0.444444444444444 0.00564174894217207
HPA HPA:0470683 skin 2; epidermal cells[High] 0.0490113839732349 1346 18 8 0.444444444444444 0.00594353640416048
HPA HPA:0620223 vagina; squamous epithelial cells[High] 0.0490113839732349 1091 10 5 0.5 0.00458295142071494
HPA HPA:0600433 tonsil; germinal center cells[High] 0.0490113839732349 1179 13 6 0.461538461538462 0.00508905852417303
HPA HPA:0090922 cerebellum; GLUC cells - cytoplasm/membrane[≥Medium] 0.0492325248840873 179 16 3 0.1875 0.0167597765363128
HPA HPA:0110223 cervix, uterine; squamous epithelial cells[High] 0.0492325248840873 986 7 4 0.571428571428571 0.00405679513184584
HPA HPA:0250133 hippocampus; neuronal cells[High] 0.0492325248840873 1210 18 7 0.388888888888889 0.00578512396694215
HPA HPA:0320103 nasopharynx; respiratory epithelial cells[High] 0.0492325248840873 1844 7 5 0.714285714285714 0.0027114967462039
HPA HPA:0110222 cervix, uterine; squamous epithelial cells[≥Medium] 0.0494958003550212 3617 12 9 0.75 0.00248824993088195
HPA HPA:0250132 hippocampus; neuronal cells[≥Medium] 0.0494958003550212 4126 18 13 0.722222222222222 0.00315075133301018
HPA HPA:0030053 appendix; glandular cells[High] 0.0494958003550212 1986 7 5 0.714285714285714 0.00251762336354481
HPA HPA:0620222 vagina; squamous epithelial cells[≥Medium] 0.0494958003550212 3945 13 10 0.769230769230769 0.00253485424588086
HPA HPA:0351181 pancreas; pancreatic endocrine cells[≥Low] 0.0494958003550212 5497 19 16 0.842105263157895 0.00291067855193742
HPA HPA:0600431 tonsil; germinal center cells[≥Low] 0.0494958003550212 5845 13 12 0.923076923076923 0.00205303678357571
HPA HPA:0090921 cerebellum; GLUC cells - cytoplasm/membrane[≥Low] 0.0494958003550212 197 16 3 0.1875 0.0152284263959391
HPA HPA:0091072 cerebellum; white matter cells - cytoplasm/membrane[≥Medium] 0.0494958003550212 225 16 3 0.1875 0.0133333333333333
HPA HPA:0090952 cerebellum; Purkinje cells - dendrites[≥Medium] 0.0494958003550212 210 16 3 0.1875 0.0142857142857143
HPA HPA:0060103 bronchus; respiratory epithelial cells[High] 0.0494958003550212 1890 7 5 0.714285714285714 0.00264550264550265
HPA HPA:0090951 cerebellum; Purkinje cells - dendrites[≥Low] 0.0494958003550212 230 16 3 0.1875 0.0130434782608696
HPA HPA:0090941 cerebellum; Purkinje cells - cytoplasm/membrane[≥Low] 0.0494958003550212 448 16 4 0.25 0.00892857142857143
HPA HPA:0470682 skin 2; epidermal cells[≥Medium] 0.0494958003550212 4735 16 13 0.8125 0.0027455121436114
HPA HPA:0160252 endometrium 1; cells in endometrial stroma[≥Medium] 0.0494958003550212 2142 18 9 0.5 0.00420168067226891
HPA HPA:0190222 esophagus; squamous epithelial cells[≥Medium] 0.0494958003550212 4937 16 13 0.8125 0.00263317804334616
KEGG KEGG:03010 Ribosome 2.02642884545031e-08 153 12 7 0.583333333333333 0.0457516339869281
KEGG KEGG:05171 Coronavirus disease - COVID-19 1.81910789601231e-07 231 12 7 0.583333333333333 0.0303030303030303
KEGG KEGG:00190 Oxidative phosphorylation 3.36545423095654e-06 133 18 6 0.333333333333333 0.0451127819548872
KEGG KEGG:04932 Non-alcoholic fatty liver disease 5.14792004551032e-06 150 18 6 0.333333333333333 0.04
KEGG KEGG:05415 Diabetic cardiomyopathy 2.42486385640844e-05 203 18 6 0.333333333333333 0.0295566502463054
KEGG KEGG:04714 Thermogenesis 4.37563934866201e-05 232 18 6 0.333333333333333 0.0258620689655172
KEGG KEGG:05012 Parkinson disease 5.63146056873954e-05 249 18 6 0.333333333333333 0.0240963855421687
KEGG KEGG:05020 Prion disease 8.33759551893318e-05 273 18 6 0.333333333333333 0.021978021978022
KEGG KEGG:05016 Huntington disease 0.000127411210546351 306 18 6 0.333333333333333 0.0196078431372549
KEGG KEGG:04260 Cardiac muscle contraction 0.000127411210546351 87 18 4 0.222222222222222 0.0459770114942529
KEGG KEGG:05014 Amyotrophic lateral sclerosis 0.000301698071759143 363 18 6 0.333333333333333 0.0165289256198347
KEGG KEGG:05010 Alzheimer disease 0.000302930331786108 369 18 6 0.333333333333333 0.016260162601626
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 0.0010353129591003 475 18 6 0.333333333333333 0.0126315789473684
KEGG KEGG:01100 Metabolic pathways 0.0162761069437428 1490 18 8 0.444444444444444 0.00536912751677852
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 1.65826649949098e-12 94 12 8 0.666666666666667 0.0851063829787234
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 6.18649086784133e-11 94 12 7 0.583333333333333 0.074468085106383
REAC REAC:R-HSA-192823 Viral mRNA Translation 6.18649086784133e-11 90 12 7 0.583333333333333 0.0777777777777778
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 6.18649086784133e-11 94 12 7 0.583333333333333 0.074468085106383
REAC REAC:R-HSA-156902 Peptide chain elongation 6.18649086784133e-11 90 12 7 0.583333333333333 0.0777777777777778
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 6.18649086784133e-11 96 12 7 0.583333333333333 0.0729166666666667
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 7.17074121055067e-11 102 12 7 0.583333333333333 0.0686274509803922
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 7.17074121055067e-11 102 12 7 0.583333333333333 0.0686274509803922
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 1.08563055734934e-10 113 12 7 0.583333333333333 0.0619469026548673
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 1.08563055734934e-10 113 12 7 0.583333333333333 0.0619469026548673
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 1.08563055734934e-10 112 12 7 0.583333333333333 0.0625
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 1.09355078061368e-10 116 12 7 0.583333333333333 0.0603448275862069
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 1.09355078061368e-10 117 12 7 0.583333333333333 0.0598290598290598
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 1.09355078061368e-10 116 12 7 0.583333333333333 0.0603448275862069
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 1.14628324178516e-10 120 12 7 0.583333333333333 0.0583333333333333
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 1.14628324178516e-10 120 12 7 0.583333333333333 0.0583333333333333
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 2.24379461799355e-10 133 12 7 0.583333333333333 0.0526315789473684
REAC REAC:R-HSA-168255 Influenza Infection 5.46364411952763e-10 152 12 7 0.583333333333333 0.0460526315789474
REAC REAC:R-HSA-9711097 Cellular response to starvation 6.50800201267447e-10 157 12 7 0.583333333333333 0.0445859872611465
REAC REAC:R-HSA-72766 Translation 8.28206012685206e-10 292 12 8 0.666666666666667 0.0273972602739726
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 1.07643183833102e-09 171 12 7 0.583333333333333 0.0409356725146199
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.6571434317831e-09 183 12 7 0.583333333333333 0.0382513661202186
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 2.3046896459402e-09 193 12 7 0.583333333333333 0.0362694300518135
REAC REAC:R-HSA-72312 rRNA processing 3.14955639907145e-09 203 12 7 0.583333333333333 0.0344827586206897
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 4.82681555832465e-09 217 12 7 0.583333333333333 0.032258064516129
REAC REAC:R-HSA-1430728 Metabolism 4.60000792968747e-08 2070 18 15 0.833333333333333 0.0072463768115942
REAC REAC:R-HSA-611105 Respiratory electron transport 4.60000792968747e-08 100 18 6 0.333333333333333 0.06
REAC REAC:R-HSA-2262752 Cellular responses to stress 8.46448950681011e-08 546 12 8 0.666666666666667 0.0146520146520147
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 9.97099796701927e-08 560 12 8 0.666666666666667 0.0142857142857143
REAC REAC:R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 1.41563780286511e-07 52 8 4 0.5 0.0769230769230769
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1.46317374836846e-07 124 18 6 0.333333333333333 0.0483870967741935
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 1.48538295100978e-07 368 12 7 0.583333333333333 0.0190217391304348
REAC REAC:R-HSA-72702 Ribosomal scanning and start codon recognition 2.09542166842617e-07 59 8 4 0.5 0.0677966101694915
REAC REAC:R-HSA-72649 Translation initiation complex formation 2.09542166842617e-07 59 8 4 0.5 0.0677966101694915
REAC REAC:R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 2.1802844470873e-07 60 8 4 0.5 0.0666666666666667
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 9.48884711204608e-07 174 18 6 0.333333333333333 0.0344827586206897
REAC REAC:R-HSA-422475 Axon guidance 1.99195393532775e-06 549 12 7 0.583333333333333 0.0127504553734062
REAC REAC:R-HSA-9675108 Nervous system development 2.62477387208836e-06 574 12 7 0.583333333333333 0.0121951219512195
REAC REAC:R-HSA-8953854 Metabolism of RNA 6.44393502897639e-06 658 12 7 0.583333333333333 0.0106382978723404
REAC REAC:R-HSA-5663205 Infectious disease 2.63847361022767e-05 815 12 7 0.583333333333333 0.00858895705521472
REAC REAC:R-HSA-1266738 Developmental Biology 0.000154405401034386 1069 12 7 0.583333333333333 0.00654817586529467
REAC REAC:R-HSA-1643685 Disease 0.00064595141369434 1509 14 8 0.571428571428571 0.00530152418820411
REAC REAC:R-HSA-392499 Metabolism of proteins 0.000930722462217614 1961 12 8 0.666666666666667 0.00407955124936257
WP WP:WP477 Cytoplasmic Ribosomal Proteins 6.73337075508609e-10 90 12 7 0.583333333333333 0.0777777777777778
WP WP:WP4396 Nonalcoholic fatty liver disease 1.98456876959105e-05 159 18 6 0.333333333333333 0.0377358490566038
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 2.93799934084231e-05 105 18 5 0.277777777777778 0.0476190476190476
WP WP:WP4921 Mitochondrial CIII assembly 2.93799934084231e-05 16 15 3 0.2 0.1875
WP WP:WP2884 NRF2 pathway 0.00908292525542887 145 14 3 0.214285714285714 0.0206896551724138
WP WP:WP2882 Nuclear Receptors Meta-Pathway 0.0410929661274126 321 14 3 0.214285714285714 0.00934579439252336

pEpiTp06 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp06
Possible regulators of activation of pEpiTp06 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.