pEpi19

pEpi19 program activity among Epithelial cells
Epithelial cell compositional overview
pEpi19 top program genes
pEpi19 gene-set enrichment of top program genes (using g-profiler)
pEpi19 transcription factor target enrichment of top program genes

pEpi19 program activity among Epithelial cells

Activation of pEpi19 — pEpi19 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition — Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.

Gene program activation of pEpi19 by different cell subtypes — pEpi19 gene program activation among cells of different subtypes (Epithelial cells).

pEpi19 top program genes

Top genes of pEpi19 program — Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi19 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi19 — pEpi19 gene-set enrichment summary using g-profiler webtool.

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Source	termID	Name	Padj	Tsize	Qsize	Overlap	Precision	Recall
CORUM	CORUM:306	Ribosome, cytoplasmic	5.67879168270501e-44	80	29	27	0.931034482758621	0.3375
CORUM	CORUM:3055	Nop56p-associated pre-rRNA complex	1.86679573786903e-29	104	28	22	0.785714285714286	0.211538461538462
CORUM	CORUM:308	60S ribosomal subunit, cytoplasmic	7.37775809948509e-24	47	29	16	0.551724137931034	0.340425531914894
CORUM	CORUM:338	40S ribosomal subunit, cytoplasmic	1.18230355285653e-16	31	28	11	0.392857142857143	0.354838709677419
CORUM	CORUM:305	40S ribosomal subunit, cytoplasmic	2.14324695522092e-16	33	28	11	0.392857142857143	0.333333333333333
CORUM	CORUM:5380	TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle)	1.68208561145807e-12	25	24	8	0.333333333333333	0.32
GO:BP	GO:0006614	SRP-dependent cotranslational protein targeting to membrane	1.9082434017361e-58	96	29	27	0.931034482758621	0.28125
GO:BP	GO:0006613	cotranslational protein targeting to membrane	6.37638774905779e-58	102	29	27	0.931034482758621	0.264705882352941
GO:BP	GO:0045047	protein targeting to ER	1.0090070897552e-56	113	29	27	0.931034482758621	0.238938053097345
GO:BP	GO:0072599	establishment of protein localization to endoplasmic reticulum	2.19473205172514e-56	117	29	27	0.931034482758621	0.230769230769231

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pEpi19 transcription factor target enrichment of top program genes

TF enrichment of pEpi19 — Possible regulators of activation of pEpi19 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.