pEpiTd17 program activity among Epithelial cells

Activation of pEpiTd17
pEpiTd17 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd17 by different cell subtypes
pEpiTd17 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd17 top program genes

Top genes of pEpiTd17 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd17 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd17
pEpiTd17 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:5232 TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) 0.0332532511907512 17 46 3 0.0652173913043478 0.176470588235294
GO:BP GO:0034097 response to cytokine 2.51687827572273e-09 1226 54 22 0.407407407407407 0.0179445350734095
GO:BP GO:0019221 cytokine-mediated signaling pathway 2.51687827572273e-09 810 54 19 0.351851851851852 0.0234567901234568
GO:BP GO:0070098 chemokine-mediated signaling pathway 2.56774940287184e-09 87 5 5 1 0.0574712643678161
GO:BP GO:1990868 response to chemokine 2.68712119200024e-09 97 5 5 1 0.0515463917525773
GO:BP GO:1990869 cellular response to chemokine 2.68712119200024e-09 97 5 5 1 0.0515463917525773
GO:BP GO:0032496 response to lipopolysaccharide 2.76727451231401e-09 338 74 15 0.202702702702703 0.0443786982248521
GO:BP GO:0030593 neutrophil chemotaxis 2.76727451231401e-09 103 5 5 1 0.0485436893203883
GO:BP GO:0071621 granulocyte chemotaxis 5.09151548574555e-09 126 5 5 1 0.0396825396825397
GO:BP GO:1990266 neutrophil migration 5.09151548574555e-09 124 5 5 1 0.0403225806451613
GO:BP GO:0002237 response to molecule of bacterial origin 5.09151548574555e-09 361 74 15 0.202702702702703 0.0415512465373961
GO:BP GO:0071345 cellular response to cytokine stimulus 8.97824528490146e-09 1132 54 20 0.37037037037037 0.0176678445229682
GO:BP GO:0097530 granulocyte migration 1.06299730253674e-08 151 5 5 1 0.033112582781457
GO:BP GO:0009617 response to bacterium 3.07597048864401e-08 743 26 12 0.461538461538462 0.0161507402422611
GO:BP GO:0097529 myeloid leukocyte migration 6.25067825431782e-08 221 5 5 1 0.0226244343891403
GO:BP GO:0030595 leukocyte chemotaxis 6.67818307186511e-08 227 5 5 1 0.0220264317180617
GO:BP GO:0019730 antimicrobial humoral response 2.23094245703455e-07 145 26 7 0.269230769230769 0.0482758620689655
GO:BP GO:0010033 response to organic substance 2.27186452355359e-07 3412 56 31 0.553571428571429 0.00908558030480656
GO:BP GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide 2.53429387736949e-07 81 26 6 0.230769230769231 0.0740740740740741
GO:BP GO:0060326 cell chemotaxis 2.53429387736949e-07 310 5 5 1 0.0161290322580645
GO:BP GO:0071222 cellular response to lipopolysaccharide 4.51748090089636e-07 200 22 7 0.318181818181818 0.035
GO:BP GO:0071219 cellular response to molecule of bacterial origin 6.88651603440363e-07 214 22 7 0.318181818181818 0.0327102803738318
GO:BP GO:0002376 immune system process 8.91773798991915e-07 3278 46 26 0.565217391304348 0.00793166564978645
GO:BP GO:0006950 response to stress 1.25867352897203e-06 4170 26 20 0.769230769230769 0.00479616306954436
GO:BP GO:0071216 cellular response to biotic stimulus 1.25867352897203e-06 238 22 7 0.318181818181818 0.0294117647058824
GO:BP GO:0043207 response to external biotic stimulus 2.01399622807738e-06 1594 45 18 0.4 0.0112923462986198
GO:BP GO:0051707 response to other organism 2.01399622807738e-06 1592 45 18 0.4 0.0113065326633166
GO:BP GO:0050900 leukocyte migration 2.17415474330046e-06 511 5 5 1 0.00978473581213307
GO:BP GO:2001233 regulation of apoptotic signaling pathway 2.17415474330046e-06 363 103 14 0.135922330097087 0.0385674931129477
GO:BP GO:0009607 response to biotic stimulus 2.38147384518146e-06 1626 45 18 0.4 0.011070110701107
GO:BP GO:0045321 leukocyte activation 2.38147384518146e-06 1332 59 19 0.322033898305085 0.0142642642642643
GO:BP GO:0001775 cell activation 2.51717576657837e-06 1495 59 20 0.338983050847458 0.0133779264214047
GO:BP GO:0006954 inflammatory response 2.93417481952585e-06 794 24 10 0.416666666666667 0.0125944584382872
GO:BP GO:0035556 intracellular signal transduction 3.75879931068776e-06 2772 46 23 0.5 0.0082972582972583
GO:BP GO:0042221 response to chemical 3.77267454503701e-06 4781 46 30 0.652173913043478 0.00627483790002092
GO:BP GO:0097190 apoptotic signaling pathway 4.36807072289692e-06 600 103 17 0.16504854368932 0.0283333333333333
GO:BP GO:0006935 chemotaxis 5.46990711604e-06 653 5 5 1 0.00765696784073507
GO:BP GO:0033993 response to lipid 5.46990711604e-06 918 55 15 0.272727272727273 0.0163398692810458
GO:BP GO:0042330 taxis 5.46990711604e-06 656 5 5 1 0.00762195121951219
GO:BP GO:0009605 response to external stimulus 5.90740667501313e-06 2944 45 23 0.511111111111111 0.0078125
GO:BP GO:0070887 cellular response to chemical stimulus 7.87929339120224e-06 3393 30 19 0.633333333333333 0.00559976422045388
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 8.58273231555646e-06 2255 45 20 0.444444444444444 0.00886917960088692
GO:BP GO:0007154 cell communication 1.02824780128525e-05 6829 46 35 0.760869565217391 0.00512520134719578
GO:BP GO:1901700 response to oxygen-containing compound 1.99614300736949e-05 1739 44 17 0.386363636363636 0.0097757331799885
GO:BP GO:0002544 chronic inflammatory response 2.19357030919233e-05 19 55 4 0.0727272727272727 0.210526315789474
GO:BP GO:0006952 defense response 2.23836737286294e-05 1818 26 13 0.5 0.00715071507150715
GO:BP GO:0042981 regulation of apoptotic process 2.66511330677181e-05 1549 103 26 0.252427184466019 0.0167850225952227
GO:BP GO:0043067 regulation of programmed cell death 3.91778032979072e-05 1582 103 26 0.252427184466019 0.0164348925410872
GO:BP GO:2001235 positive regulation of apoptotic signaling pathway 5.05906686293152e-05 129 103 8 0.0776699029126214 0.062015503875969
GO:BP GO:0006959 humoral immune response 5.84734724181439e-05 384 26 7 0.269230769230769 0.0182291666666667
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 6.13509150050839e-05 294 103 11 0.106796116504854 0.0374149659863946
GO:BP GO:0051716 cellular response to stimulus 7.3199893356188e-05 7781 46 36 0.782608695652174 0.00462665467163604
GO:BP GO:0007165 signal transduction 7.76835587092782e-05 6309 29 23 0.793103448275862 0.00364558567126327
GO:BP GO:0016477 cell migration 8.69058744573853e-05 1649 110 27 0.245454545454545 0.0163735597331716
GO:BP GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 8.69124564141969e-05 62 103 6 0.058252427184466 0.0967741935483871
GO:BP GO:0071310 cellular response to organic substance 9.19697604503388e-05 2776 30 16 0.533333333333333 0.00576368876080692
GO:BP GO:1902531 regulation of intracellular signal transduction 0.000102061363886696 1842 29 13 0.448275862068966 0.00705754614549403
GO:BP GO:0008285 negative regulation of cell population proliferation 0.000123186522228254 790 44 11 0.25 0.0139240506329114
GO:BP GO:0040011 locomotion 0.00013069682024386 2028 44 17 0.386363636363636 0.00838264299802761
GO:BP GO:0007186 G protein-coupled receptor signaling pathway 0.00013351057574635 1355 5 5 1 0.003690036900369
GO:BP GO:0051674 localization of cell 0.000141592591814521 1828 39 15 0.384615384615385 0.00820568927789934
GO:BP GO:0023052 signaling 0.000141592591814521 6810 30 24 0.8 0.00352422907488987
GO:BP GO:0048870 cell motility 0.000141592591814521 1828 39 15 0.384615384615385 0.00820568927789934
GO:BP GO:0010941 regulation of cell death 0.000141811543162713 1720 103 26 0.252427184466019 0.0151162790697674
GO:BP GO:0048522 positive regulation of cellular process 0.000169580256778331 5757 46 30 0.652173913043478 0.00521104742053153
GO:BP GO:0001944 vasculature development 0.000170506069225896 830 44 11 0.25 0.0132530120481928
GO:BP GO:0012501 programmed cell death 0.000170506069225896 2143 106 30 0.283018867924528 0.0139990667288847
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 0.000170506069225896 162 134 9 0.0671641791044776 0.0555555555555556
GO:BP GO:0071396 cellular response to lipid 0.000181651848081918 578 22 7 0.318181818181818 0.0121107266435986
GO:BP GO:0048708 astrocyte differentiation 0.000187577565455992 78 55 5 0.0909090909090909 0.0641025641025641
GO:BP GO:0006955 immune response 0.000196483011404573 2311 45 18 0.4 0.00778883600173085
GO:BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.000196483011404573 138 56 6 0.107142857142857 0.0434782608695652
GO:BP GO:0002467 germinal center formation 0.000196483011404573 14 42 3 0.0714285714285714 0.214285714285714
GO:BP GO:0051179 localization 0.00020574264251424 6901 39 29 0.743589743589744 0.0042022895232575
GO:BP GO:0008219 cell death 0.00020574264251424 2292 106 31 0.292452830188679 0.0135253054101222
GO:BP GO:0034612 response to tumor necrosis factor 0.000211972812168236 331 130 12 0.0923076923076923 0.0362537764350453
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.000211972812168236 306 75 9 0.12 0.0294117647058824
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.000219307724559146 167 103 8 0.0776699029126214 0.0479041916167665
GO:BP GO:0002682 regulation of immune system process 0.000226269185706927 1617 51 16 0.313725490196078 0.00989486703772418
GO:BP GO:0050896 response to stimulus 0.000250240908151606 9407 31 28 0.903225806451613 0.00297650685659615
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.000270412543122067 1227 22 9 0.409090909090909 0.00733496332518337
GO:BP GO:0038061 NIK/NF-kappaB signaling 0.000290170174411406 194 44 6 0.136363636363636 0.0309278350515464
GO:BP GO:0070664 negative regulation of leukocyte proliferation 0.00029639422233213 92 25 4 0.16 0.0434782608695652
GO:BP GO:0070486 leukocyte aggregation 0.000298983582309258 13 55 3 0.0545454545454545 0.230769230769231
GO:BP GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway 0.000304730261939157 6 134 3 0.0223880597014925 0.5
GO:BP GO:1901222 regulation of NIK/NF-kappaB signaling 0.000304730261939157 113 44 5 0.113636363636364 0.0442477876106195
GO:BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.000304730261939157 154 56 6 0.107142857142857 0.038961038961039
GO:BP GO:0010646 regulation of cell communication 0.000344579483088885 3543 45 22 0.488888888888889 0.00620942703923229
GO:BP GO:0014002 astrocyte development 0.000355033498830215 44 55 4 0.0727272727272727 0.0909090909090909
GO:BP GO:0071347 cellular response to interleukin-1 0.000360704121346847 185 134 9 0.0671641791044776 0.0486486486486487
GO:BP GO:0042127 regulation of cell population proliferation 0.000372686956463887 1774 44 15 0.340909090909091 0.0084554678692221
GO:BP GO:0032502 developmental process 0.00038320097179576 6628 45 31 0.688888888888889 0.00467712733856367
GO:BP GO:0023051 regulation of signaling 0.00038320097179576 3578 45 22 0.488888888888889 0.00614868641699273
GO:BP GO:0051238 sequestering of metal ion 0.000418772583992195 15 55 3 0.0545454545454545 0.2
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.000427897124846723 187 75 7 0.0933333333333333 0.0374331550802139
GO:BP GO:0006915 apoptotic process 0.000427897124846723 1990 103 27 0.262135922330097 0.0135678391959799
GO:BP GO:0032495 response to muramyl dipeptide 0.000437306669130322 20 134 4 0.0298507462686567 0.2
GO:BP GO:0061028 establishment of endothelial barrier 0.000439350952471519 50 110 5 0.0454545454545455 0.1
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.000491564274932215 3274 56 24 0.428571428571429 0.00733048259010385
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.000540923520508974 375 55 8 0.145454545454545 0.0213333333333333
GO:BP GO:0080134 regulation of response to stress 0.000586983114975774 1443 134 26 0.194029850746269 0.018018018018018
GO:BP GO:0051235 maintenance of location 0.000606230177869158 337 62 8 0.129032258064516 0.0237388724035608
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 0.000616041397048877 1197 44 12 0.272727272727273 0.0100250626566416
GO:BP GO:0010952 positive regulation of peptidase activity 0.000704545334997507 205 75 7 0.0933333333333333 0.0341463414634146
GO:BP GO:0065009 regulation of molecular function 0.000704545334997507 3221 58 24 0.413793103448276 0.00745110214219187
GO:BP GO:0050729 positive regulation of inflammatory response 0.000708757876462847 142 108 7 0.0648148148148148 0.0492957746478873
GO:BP GO:0009966 regulation of signal transduction 0.000733425220075754 3165 45 20 0.444444444444444 0.00631911532385466
GO:BP GO:0008283 cell population proliferation 0.000813917680114679 2054 51 17 0.333333333333333 0.00827653359298929
GO:BP GO:0002274 myeloid leukocyte activation 0.00085332157824413 667 55 10 0.181818181818182 0.0149925037481259
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0008692596425546 3210 20 12 0.6 0.00373831775700935
GO:BP GO:0055069 zinc ion homeostasis 0.000894050425261893 39 83 4 0.0481927710843374 0.102564102564103
GO:BP GO:0070555 response to interleukin-1 0.000895188919259563 215 75 7 0.0933333333333333 0.0325581395348837
GO:BP GO:0048518 positive regulation of biological process 0.000898637502845068 6363 46 30 0.652173913043478 0.00471475719000472
GO:BP GO:0030334 regulation of cell migration 0.000901388736004904 999 110 18 0.163636363636364 0.018018018018018
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 0.000954564148702874 270 134 10 0.0746268656716418 0.037037037037037
GO:BP GO:0006928 movement of cell or subcellular component 0.000962586249888043 2311 110 30 0.272727272727273 0.0129813933362181
GO:BP GO:0007155 cell adhesion 0.000964501936900601 1492 76 18 0.236842105263158 0.0120643431635389
GO:BP GO:0022610 biological adhesion 0.00101772733392926 1499 76 18 0.236842105263158 0.0120080053368913
GO:BP GO:0048585 negative regulation of response to stimulus 0.00103733074943522 1733 44 14 0.318181818181818 0.00807847663012118
GO:BP GO:0043065 positive regulation of apoptotic process 0.00104923678885804 604 103 13 0.12621359223301 0.021523178807947
GO:BP GO:0051101 regulation of DNA binding 0.00108869942072597 121 29 4 0.137931034482759 0.0330578512396694
GO:BP GO:0048856 anatomical structure development 0.00130859896346836 6106 59 35 0.593220338983051 0.00573206681952178
GO:BP GO:0043068 positive regulation of programmed cell death 0.00136135921628366 621 103 13 0.12621359223301 0.0209339774557166
GO:BP GO:0051247 positive regulation of protein metabolic process 0.00140393683969493 1564 75 18 0.24 0.0115089514066496
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00143753902441359 217 56 6 0.107142857142857 0.0276497695852535
GO:BP GO:0048731 system development 0.00143753902441359 5052 59 31 0.525423728813559 0.00613618368962787
GO:BP GO:0043066 negative regulation of apoptotic process 0.00146370966377211 921 44 10 0.227272727272727 0.01085776330076
GO:BP GO:0048583 regulation of response to stimulus 0.0014657821879172 4278 45 23 0.511111111111111 0.00537634408602151
GO:BP GO:0030335 positive regulation of cell migration 0.00147450808317448 567 44 8 0.181818181818182 0.0141093474426808
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.00148078067261247 156 25 4 0.16 0.0256410256410256
GO:BP GO:0043588 skin development 0.00148658385988684 424 111 11 0.0990990990990991 0.0259433962264151
GO:BP GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 0.00150508221028627 14 102 3 0.0294117647058824 0.214285714285714
GO:BP GO:0007275 multicellular organism development 0.00150508221028627 5613 59 33 0.559322033898305 0.00587920897915553
GO:BP GO:0001885 endothelial cell development 0.0015317717105754 69 110 5 0.0454545454545455 0.072463768115942
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0015317717105754 3083 56 22 0.392857142857143 0.00713590658449562
GO:BP GO:2000145 regulation of cell motility 0.0016457413407831 1061 110 18 0.163636363636364 0.0169651272384543
GO:BP GO:0043069 negative regulation of programmed cell death 0.00165647221349802 943 44 10 0.227272727272727 0.0106044538706257
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.00165647221349802 291 44 6 0.136363636363636 0.0206185567010309
GO:BP GO:0098869 cellular oxidant detoxification 0.00168858209250462 100 15 3 0.2 0.03
GO:BP GO:2000147 positive regulation of cell motility 0.00182011803193357 591 44 8 0.181818181818182 0.0135363790186125
GO:BP GO:0033554 cellular response to stress 0.00182221556965521 2111 22 10 0.454545454545455 0.00473709142586452
GO:BP GO:0098609 cell-cell adhesion 0.001872688699473 894 76 13 0.171052631578947 0.0145413870246085
GO:BP GO:0042742 defense response to bacterium 0.00197243524032695 349 55 7 0.127272727272727 0.0200573065902579
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.00203668372463296 1477 75 17 0.226666666666667 0.011509817197021
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.00204577788269734 184 45 5 0.111111111111111 0.0271739130434783
GO:BP GO:0051272 positive regulation of cellular component movement 0.00204577788269734 604 44 8 0.181818181818182 0.0132450331125828
GO:BP GO:0040017 positive regulation of locomotion 0.00206655487333316 606 44 8 0.181818181818182 0.0132013201320132
GO:BP GO:0030155 regulation of cell adhesion 0.00208004305161908 748 46 9 0.195652173913043 0.0120320855614973
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.00211241013006728 240 56 6 0.107142857142857 0.025
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.0021524834656195 456 74 9 0.121621621621622 0.0197368421052632
GO:BP GO:0072359 circulatory system development 0.00217696390224421 1194 44 11 0.25 0.00921273031825796
GO:BP GO:0001568 blood vessel development 0.00217696390224421 792 44 9 0.204545454545455 0.0113636363636364
GO:BP GO:0032879 regulation of localization 0.00220132286601596 2872 38 16 0.421052631578947 0.00557103064066852
GO:BP GO:1990748 cellular detoxification 0.00220132286601596 113 15 3 0.2 0.0265486725663717
GO:BP GO:0040012 regulation of locomotion 0.00240019565142803 1104 110 18 0.163636363636364 0.016304347826087
GO:BP GO:0045446 endothelial cell differentiation 0.00243087208096542 125 110 6 0.0545454545454545 0.048
GO:BP GO:0002695 negative regulation of leukocyte activation 0.00253704742441257 188 25 4 0.16 0.0212765957446809
GO:BP GO:0097237 cellular response to toxic substance 0.00256101433850079 120 15 3 0.2 0.025
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.00259399793145595 197 45 5 0.111111111111111 0.0253807106598985
GO:BP GO:0060429 epithelium development 0.00265425216130757 1325 110 20 0.181818181818182 0.0150943396226415
GO:BP GO:0048584 positive regulation of response to stimulus 0.00270106405598091 2344 29 12 0.413793103448276 0.00511945392491468
GO:BP GO:0019932 second-messenger-mediated signaling 0.00270106405598091 327 44 6 0.136363636363636 0.018348623853211
GO:BP GO:0010942 positive regulation of cell death 0.00270251527787101 684 103 13 0.12621359223301 0.0190058479532164
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00270251527787101 3483 56 23 0.410714285714286 0.00660350272753374
GO:BP GO:0046425 regulation of receptor signaling pathway via JAK-STAT 0.00272182964288707 108 44 4 0.0909090909090909 0.037037037037037
GO:BP GO:0010648 negative regulation of cell communication 0.00279065607734143 1468 44 12 0.272727272727273 0.00817438692098093
GO:BP GO:0023057 negative regulation of signaling 0.00281223010725159 1471 44 12 0.272727272727273 0.00815771583956492
GO:BP GO:0009893 positive regulation of metabolic process 0.00281223010725159 3783 46 21 0.456521739130435 0.00555114988104679
GO:BP GO:0050727 regulation of inflammatory response 0.00286987908357037 381 55 7 0.127272727272727 0.0183727034120735
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 0.00288584168827735 1967 44 14 0.318181818181818 0.00711743772241993
GO:BP GO:0034341 response to interferon-gamma 0.00289200545544312 196 74 6 0.0810810810810811 0.0306122448979592
GO:BP GO:0060548 negative regulation of cell death 0.00292370408619731 1038 44 10 0.227272727272727 0.00963391136801541
GO:BP GO:0009653 anatomical structure morphogenesis 0.00302774880750557 2797 44 17 0.386363636363636 0.00607794065069718
GO:BP GO:0072678 T cell migration 0.00304612227913584 67 74 4 0.0540540540540541 0.0597014925373134
GO:BP GO:0098754 detoxification 0.00313024346804576 134 15 3 0.2 0.0223880597014925
GO:BP GO:0051270 regulation of cellular component movement 0.00313024346804576 1141 110 18 0.163636363636364 0.0157756354075372
GO:BP GO:0006875 cellular metal ion homeostasis 0.00322493785863907 593 62 9 0.145161290322581 0.015177065767285
GO:BP GO:0009891 positive regulation of biosynthetic process 0.00330977814273646 2004 44 14 0.318181818181818 0.00698602794411178
GO:BP GO:0032940 secretion by cell 0.00330977814273646 1364 35 10 0.285714285714286 0.00733137829912024
GO:BP GO:0050866 negative regulation of cell activation 0.00335221734264714 211 25 4 0.16 0.018957345971564
GO:BP GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 0.00335221734264714 92 56 4 0.0714285714285714 0.0434782608695652
GO:BP GO:1904892 regulation of receptor signaling pathway via STAT 0.00338597098587155 118 44 4 0.0909090909090909 0.0338983050847458
GO:BP GO:0070663 regulation of leukocyte proliferation 0.00339237226446862 251 39 5 0.128205128205128 0.0199203187250996
GO:BP GO:0006882 cellular zinc ion homeostasis 0.00339237226446862 37 55 3 0.0545454545454545 0.0810810810810811
GO:BP GO:0032101 regulation of response to external stimulus 0.00360083937887589 1051 45 10 0.222222222222222 0.00951474785918173
GO:BP GO:0050672 negative regulation of lymphocyte proliferation 0.00371668598702076 85 25 3 0.12 0.0352941176470588
GO:BP GO:0032945 negative regulation of mononuclear cell proliferation 0.00382779030588264 86 25 3 0.12 0.0348837209302326
GO:BP GO:0002685 regulation of leukocyte migration 0.00383211060226294 211 74 6 0.0810810810810811 0.028436018957346
GO:BP GO:0002761 regulation of myeloid leukocyte differentiation 0.00383211060226294 123 44 4 0.0909090909090909 0.032520325203252
GO:BP GO:0003158 endothelium development 0.00404896893823522 143 110 6 0.0545454545454545 0.041958041958042
GO:BP GO:0002683 negative regulation of immune system process 0.00404896893823522 420 25 5 0.2 0.0119047619047619
GO:BP GO:0002687 positive regulation of leukocyte migration 0.00412800451363515 137 74 5 0.0675675675675676 0.0364963503649635
GO:BP GO:0140352 export from cell 0.00418077201992653 1418 35 10 0.285714285714286 0.00705218617771509
GO:BP GO:0009615 response to virus 0.00440733617119588 364 45 6 0.133333333333333 0.0164835164835165
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.00461465145103261 497 62 8 0.129032258064516 0.0160965794768612
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.00465941089102908 1037 56 11 0.196428571428571 0.0106075216972035
GO:BP GO:0071675 regulation of mononuclear cell migration 0.00468312711057336 113 51 4 0.0784313725490196 0.0353982300884956
GO:BP GO:0035239 tube morphogenesis 0.00470047351906879 950 26 7 0.269230769230769 0.00736842105263158
GO:BP GO:0070661 leukocyte proliferation 0.00470047351906879 325 51 6 0.117647058823529 0.0184615384615385
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 0.00470047351906879 177 130 7 0.0538461538461538 0.0395480225988701
GO:BP GO:0009968 negative regulation of signal transduction 0.00510597454571527 1364 44 11 0.25 0.00806451612903226
GO:BP GO:0035295 tube development 0.00516343768446423 1146 29 8 0.275862068965517 0.00698080279232112
GO:BP GO:0030855 epithelial cell differentiation 0.00525876246412704 798 110 14 0.127272727272727 0.0175438596491228
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 0.00528191115305944 1617 44 12 0.272727272727273 0.00742115027829314
GO:BP GO:0042119 neutrophil activation 0.00528191115305944 498 35 6 0.171428571428571 0.0120481927710843
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 0.00528191115305944 1617 44 12 0.272727272727273 0.00742115027829314
GO:BP GO:0031663 lipopolysaccharide-mediated signaling pathway 0.00528191115305944 56 44 3 0.0681818181818182 0.0535714285714286
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 0.00528191115305944 1618 44 12 0.272727272727273 0.00741656365883807
GO:BP GO:0001774 microglial cell activation 0.00528191115305944 55 45 3 0.0666666666666667 0.0545454545454545
GO:BP GO:0022612 gland morphogenesis 0.00537004721404736 120 51 4 0.0784313725490196 0.0333333333333333
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.00537004721404736 516 62 8 0.129032258064516 0.0155038759689922
GO:BP GO:0031349 positive regulation of defense response 0.00541535608392642 362 134 10 0.0746268656716418 0.0276243093922652
GO:BP GO:0036230 granulocyte activation 0.00544106821017492 504 35 6 0.171428571428571 0.0119047619047619
GO:BP GO:0009790 embryo development 0.00555732182339506 1035 49 10 0.204081632653061 0.00966183574879227
GO:BP GO:0052548 regulation of endopeptidase activity 0.00555732182339506 437 56 7 0.125 0.0160183066361556
GO:BP GO:0046903 secretion 0.00575397973324489 1501 35 10 0.285714285714286 0.00666222518321119
GO:BP GO:0001890 placenta development 0.00581499086014037 147 43 4 0.0930232558139535 0.0272108843537415
GO:BP GO:1903428 positive regulation of reactive oxygen species biosynthetic process 0.00592982824338875 62 102 4 0.0392156862745098 0.0645161290322581
GO:BP GO:0055065 metal ion homeostasis 0.00598717204815385 667 62 9 0.145161290322581 0.0134932533733133
GO:BP GO:0098542 defense response to other organism 0.00598717204815385 1218 75 14 0.186666666666667 0.0114942528735632
GO:BP GO:0046916 cellular transition metal ion homeostasis 0.00601746081611148 116 55 4 0.0727272727272727 0.0344827586206897
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.00601746081611148 263 44 5 0.113636363636364 0.0190114068441065
GO:BP GO:0055076 transition metal ion homeostasis 0.00605669452730235 138 83 5 0.0602409638554217 0.036231884057971
GO:BP GO:0032103 positive regulation of response to external stimulus 0.00605669452730235 513 134 12 0.0895522388059701 0.0233918128654971
GO:BP GO:0030003 cellular cation homeostasis 0.00620619698079649 673 62 9 0.145161290322581 0.0133729569093611
GO:BP GO:0002526 acute inflammatory response 0.00643061842476367 114 102 5 0.0490196078431373 0.043859649122807
GO:BP GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 0.00662934073968375 63 44 3 0.0681818181818182 0.0476190476190476
GO:BP GO:0050434 positive regulation of viral transcription 0.00662934073968375 24 117 3 0.0256410256410256 0.125
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.00673859495736628 1202 44 10 0.227272727272727 0.00831946755407654
GO:BP GO:0030856 regulation of epithelial cell differentiation 0.00673859495736628 164 110 6 0.0545454545454545 0.0365853658536585
GO:BP GO:0021782 glial cell development 0.00694073656711909 122 55 4 0.0727272727272727 0.0327868852459016
GO:BP GO:0006873 cellular ion homeostasis 0.00697390811811699 687 62 9 0.145161290322581 0.0131004366812227
GO:BP GO:0071677 positive regulation of mononuclear cell migration 0.00706784853324242 65 44 3 0.0681818181818182 0.0461538461538462
GO:BP GO:0055082 cellular chemical homeostasis 0.00707497990885615 841 62 10 0.161290322580645 0.0118906064209275
GO:BP GO:0010035 response to inorganic substance 0.00721253281688847 575 74 9 0.121621621621622 0.0156521739130435
GO:BP GO:0022407 regulation of cell-cell adhesion 0.00723404838180653 445 76 8 0.105263157894737 0.0179775280898876
GO:BP GO:0052547 regulation of peptidase activity 0.0074519259067401 467 56 7 0.125 0.0149892933618844
GO:BP GO:0009435 NAD biosynthetic process 0.00747670357180947 29 102 3 0.0294117647058824 0.103448275862069
GO:BP GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 0.00747922977691313 83 83 4 0.0481927710843374 0.0481927710843374
GO:BP GO:0051254 positive regulation of RNA metabolic process 0.00765574465284053 1714 44 12 0.272727272727273 0.00700116686114352
GO:BP GO:0010001 glial cell differentiation 0.00765574465284053 225 55 5 0.0909090909090909 0.0222222222222222
GO:BP GO:2000810 regulation of bicellular tight junction assembly 0.00816893866817211 28 110 3 0.0272727272727273 0.107142857142857
GO:BP GO:0001525 angiogenesis 0.00834502016556238 617 44 7 0.159090909090909 0.0113452188006483
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.00854454055005303 549 36 6 0.166666666666667 0.0109289617486339
GO:BP GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 0.00854454055005303 71 44 3 0.0681818181818182 0.0422535211267606
GO:BP GO:0002224 toll-like receptor signaling pathway 0.00878740476703163 161 20 3 0.15 0.0186335403726708
GO:BP GO:0031347 regulation of defense response 0.00898330588324391 704 134 14 0.104477611940299 0.0198863636363636
GO:BP GO:0043009 chordate embryonic development 0.00899982477461246 616 58 8 0.137931034482759 0.012987012987013
GO:BP GO:1903034 regulation of response to wounding 0.00900527311538514 169 115 6 0.0521739130434783 0.0355029585798817
GO:BP GO:2000401 regulation of lymphocyte migration 0.00906465379729231 63 51 3 0.0588235294117647 0.0476190476190476
GO:BP GO:0071346 cellular response to interferon-gamma 0.00910438116907215 175 74 5 0.0675675675675676 0.0285714285714286
GO:BP GO:0019359 nicotinamide nucleotide biosynthetic process 0.00920489966199817 32 102 3 0.0294117647058824 0.09375
GO:BP GO:0019363 pyridine nucleotide biosynthetic process 0.00920489966199817 32 102 3 0.0294117647058824 0.09375
GO:BP GO:0010038 response to metal ion 0.00950388244412757 371 74 7 0.0945945945945946 0.0188679245283019
GO:BP GO:0001836 release of cytochrome c from mitochondria 0.00963321597336119 59 56 3 0.0535714285714286 0.0508474576271186
GO:BP GO:0046649 lymphocyte activation 0.00970382986853532 771 59 9 0.152542372881356 0.0116731517509728
GO:BP GO:0007259 receptor signaling pathway via JAK-STAT 0.00970909388857027 174 44 4 0.0909090909090909 0.0229885057471264
GO:BP GO:0048660 regulation of smooth muscle cell proliferation 0.00970909388857027 174 44 4 0.0909090909090909 0.0229885057471264
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.00970909388857027 159 83 5 0.0602409638554217 0.0314465408805031
GO:BP GO:0034250 positive regulation of cellular amide metabolic process 0.00986686920238854 171 45 4 0.0888888888888889 0.0233918128654971
GO:BP GO:0048659 smooth muscle cell proliferation 0.0100145458208154 176 44 4 0.0909090909090909 0.0227272727272727
GO:BP GO:0002009 morphogenesis of an epithelium 0.010077407439007 560 81 9 0.111111111111111 0.0160714285714286
GO:BP GO:1903793 positive regulation of anion transport 0.010077407439007 504 56 7 0.125 0.0138888888888889
GO:BP GO:0009792 embryo development ending in birth or egg hatching 0.0101168868777122 635 58 8 0.137931034482759 0.0125984251968504
GO:BP GO:1902117 positive regulation of organelle assembly 0.0103248437823748 68 51 3 0.0588235294117647 0.0441176470588235
GO:BP GO:1905898 positive regulation of response to endoplasmic reticulum stress 0.0103248437823748 36 97 3 0.0309278350515464 0.0833333333333333
GO:BP GO:0009314 response to radiation 0.0104495391951703 461 18 4 0.222222222222222 0.00867678958785249
GO:BP GO:0045862 positive regulation of proteolysis 0.0104495391951703 378 75 7 0.0933333333333333 0.0185185185185185
GO:BP GO:0055080 cation homeostasis 0.0104565114628988 750 62 9 0.145161290322581 0.012
GO:BP GO:0009636 response to toxic substance 0.0104565114628988 243 15 3 0.2 0.0123456790123457
GO:BP GO:0051651 maintenance of location in cell 0.0105300538488154 223 62 5 0.0806451612903226 0.0224215246636771
GO:BP GO:0048608 reproductive structure development 0.0105300538488154 429 49 6 0.122448979591837 0.013986013986014
GO:BP GO:0001892 embryonic placenta development 0.0105300538488154 83 43 3 0.0697674418604651 0.036144578313253
GO:BP GO:0046496 nicotinamide nucleotide metabolic process 0.0105300538488154 35 102 3 0.0294117647058824 0.0857142857142857
GO:BP GO:0061041 regulation of wound healing 0.0105300538488154 136 101 5 0.0495049504950495 0.0367647058823529
GO:BP GO:0072525 pyridine-containing compound biosynthetic process 0.0105300538488154 35 102 3 0.0294117647058824 0.0857142857142857
GO:BP GO:0019362 pyridine nucleotide metabolic process 0.0105300538488154 35 102 3 0.0294117647058824 0.0857142857142857
GO:BP GO:0009628 response to abiotic stimulus 0.0105300538488154 1261 18 6 0.333333333333333 0.00475812846946868
GO:BP GO:0071674 mononuclear cell migration 0.0105300538488154 191 108 6 0.0555555555555556 0.031413612565445
GO:BP GO:0010243 response to organonitrogen compound 0.0105494439435454 1085 44 9 0.204545454545455 0.00829493087557604
GO:BP GO:0036293 response to decreased oxygen levels 0.0105494439435454 382 75 7 0.0933333333333333 0.0183246073298429
GO:BP GO:0097696 receptor signaling pathway via STAT 0.0105494439435454 184 44 4 0.0909090909090909 0.0217391304347826
GO:BP GO:0061458 reproductive system development 0.0107402937917153 432 49 6 0.122448979591837 0.0138888888888889
GO:BP GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 0.0107663735846079 108 75 4 0.0533333333333333 0.037037037037037
GO:BP GO:0098771 inorganic ion homeostasis 0.0107904577007386 761 62 9 0.145161290322581 0.011826544021025
GO:BP GO:0051234 establishment of localization 0.010791544579805 5372 56 28 0.5 0.00521221146686523
GO:BP GO:0001701 in utero embryonic development 0.010791544579805 365 58 6 0.103448275862069 0.0164383561643836
GO:BP GO:1901652 response to peptide 0.0108058448477359 551 102 10 0.0980392156862745 0.0181488203266788
GO:BP GO:0051050 positive regulation of transport 0.0108058448477359 923 62 10 0.161290322580645 0.0108342361863489
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 0.0108441667006694 105 134 5 0.0373134328358209 0.0476190476190476
GO:BP GO:0036294 cellular response to decreased oxygen levels 0.0108932417487008 222 130 7 0.0538461538461538 0.0315315315315315
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.0112702476161217 329 44 5 0.113636363636364 0.0151975683890578
GO:BP GO:0072073 kidney epithelium development 0.0112702476161217 137 104 5 0.0480769230769231 0.0364963503649635
GO:BP GO:0051094 positive regulation of developmental process 0.0112702476161217 1341 44 10 0.227272727272727 0.00745712155108128
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 0.0113003419857285 1851 44 12 0.272727272727273 0.00648298217179903
GO:BP GO:0050792 regulation of viral process 0.011472496429127 192 44 4 0.0909090909090909 0.0208333333333333
GO:BP GO:0042509 regulation of tyrosine phosphorylation of STAT protein 0.0116974581333823 87 44 3 0.0681818181818182 0.0344827586206897
GO:BP GO:0035633 maintenance of blood-brain barrier 0.0117464954660449 35 110 3 0.0272727272727273 0.0857142857142857
GO:BP GO:0006970 response to osmotic stress 0.0121476996903252 84 102 4 0.0392156862745098 0.0476190476190476
GO:BP GO:0048878 chemical homeostasis 0.012204071959465 1229 83 14 0.168674698795181 0.0113913751017087
GO:BP GO:0007260 tyrosine phosphorylation of STAT protein 0.012249641964027 89 44 3 0.0681818181818182 0.0337078651685393
GO:BP GO:0010647 positive regulation of cell communication 0.0124179581927421 1777 29 9 0.310344827586207 0.00506471581316826
GO:BP GO:0072676 lymphocyte migration 0.012426654853608 117 74 4 0.0540540540540541 0.0341880341880342
GO:BP GO:0023056 positive regulation of signaling 0.0125657723200742 1782 29 9 0.310344827586207 0.00505050505050505
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.0127112645012783 1887 44 12 0.272727272727273 0.00635930047694754
GO:BP GO:0046651 lymphocyte proliferation 0.0127112645012783 294 51 5 0.0980392156862745 0.0170068027210884
GO:BP GO:0051384 response to glucocorticoid 0.0128654731072678 146 102 5 0.0490196078431373 0.0342465753424658
GO:BP GO:0032943 mononuclear cell proliferation 0.0131513368458216 297 51 5 0.0980392156862745 0.0168350168350168
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 0.0132041232014714 203 44 4 0.0909090909090909 0.0197044334975369
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.0132041232014714 230 39 4 0.102564102564103 0.0173913043478261
GO:BP GO:0070482 response to oxygen levels 0.013277234654037 408 75 7 0.0933333333333333 0.017156862745098
GO:BP GO:0006887 exocytosis 0.013277234654037 904 35 7 0.2 0.00774336283185841
GO:BP GO:0050793 regulation of developmental process 0.013338534489431 2605 29 11 0.379310344827586 0.00422264875239923
GO:BP GO:0048514 blood vessel morphogenesis 0.013338534489431 711 44 7 0.159090909090909 0.00984528832630099
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.0133820299572994 232 39 4 0.102564102564103 0.0172413793103448
GO:BP GO:0002221 pattern recognition receptor signaling pathway 0.0138359196426217 213 20 3 0.15 0.0140845070422535
GO:BP GO:0072524 pyridine-containing compound metabolic process 0.0138471435433315 41 102 3 0.0294117647058824 0.0731707317073171
GO:BP GO:0044089 positive regulation of cellular component biogenesis 0.0138502840753612 540 74 8 0.108108108108108 0.0148148148148148
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.0139585132768081 338 46 5 0.108695652173913 0.014792899408284
GO:BP GO:0050801 ion homeostasis 0.0140632218115253 808 62 9 0.145161290322581 0.0111386138613861
GO:BP GO:0006810 transport 0.0141122068000891 5224 56 27 0.482142857142857 0.00516845329249617
GO:BP GO:0032501 multicellular organismal process 0.0142050233198205 7946 45 30 0.666666666666667 0.00377548452051347
GO:BP GO:0042493 response to drug 0.0142050233198205 396 24 4 0.166666666666667 0.0101010101010101
GO:BP GO:0019725 cellular homeostasis 0.0142958506253712 981 62 10 0.161290322580645 0.0101936799184506
GO:BP GO:0065008 regulation of biological quality 0.0142958506253712 4131 56 23 0.410714285714286 0.0055676591624304
GO:BP GO:0071453 cellular response to oxygen levels 0.0143922526916306 240 130 7 0.0538461538461538 0.0291666666666667
GO:BP GO:0050832 defense response to fungus 0.0143922526916306 40 108 3 0.0277777777777778 0.075
GO:BP GO:0002573 myeloid leukocyte differentiation 0.0143922526916306 213 44 4 0.0909090909090909 0.0187793427230047
GO:BP GO:1901698 response to nitrogen compound 0.0143922526916306 1172 44 9 0.204545454545455 0.00767918088737201
GO:BP GO:0045471 response to ethanol 0.0143922526916306 142 110 5 0.0454545454545455 0.0352112676056338
GO:BP GO:0000302 response to reactive oxygen species 0.0147075149737812 237 40 4 0.1 0.0168776371308017
GO:BP GO:0048869 cellular developmental process 0.0149572794411711 4428 59 25 0.423728813559322 0.00564588979223126
GO:BP GO:0051249 regulation of lymphocyte activation 0.0150523783729243 518 46 6 0.130434782608696 0.0115830115830116
GO:BP GO:0008544 epidermis development 0.0150523783729243 475 106 9 0.0849056603773585 0.0189473684210526
GO:BP GO:0018198 peptidyl-cysteine modification 0.0152442801052033 48 93 3 0.032258064516129 0.0625
GO:BP GO:0072080 nephron tubule development 0.015343293840639 92 104 4 0.0384615384615385 0.0434782608695652
GO:BP GO:0009914 hormone transport 0.0159140953032802 327 50 5 0.1 0.0152905198776758
GO:BP GO:0045429 positive regulation of nitric oxide biosynthetic process 0.016208386179307 45 102 3 0.0294117647058824 0.0666666666666667
GO:BP GO:0050794 regulation of cellular process 0.016208386179307 11473 48 40 0.833333333333333 0.00348644643946657
GO:BP GO:0002064 epithelial cell development 0.0167713955710373 218 110 6 0.0545454545454545 0.0275229357798165
GO:BP GO:2000351 regulation of endothelial cell apoptotic process 0.0168057330923879 63 74 3 0.0405405405405405 0.0476190476190476
GO:BP GO:2001234 negative regulation of apoptotic signaling pathway 0.0168057330923879 236 102 6 0.0588235294117647 0.0254237288135593
GO:BP GO:0048519 negative regulation of biological process 0.0168057330923879 5757 45 24 0.533333333333333 0.00416883793642522
GO:BP GO:1904407 positive regulation of nitric oxide metabolic process 0.0168057330923879 46 102 3 0.0294117647058824 0.0652173913043478
GO:BP GO:0061326 renal tubule development 0.0168057330923879 95 104 4 0.0384615384615385 0.0421052631578947
GO:BP GO:0043312 neutrophil degranulation 0.0168057330923879 482 35 5 0.142857142857143 0.0103734439834025
GO:BP GO:0007568 aging 0.017076631000753 329 74 6 0.0810810810810811 0.0182370820668693
GO:BP GO:0002283 neutrophil activation involved in immune response 0.017076631000753 485 35 5 0.142857142857143 0.0103092783505155
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0173118127648948 717 35 6 0.171428571428571 0.00836820083682008
GO:BP GO:0033002 muscle cell proliferation 0.0174888416893981 244 20 3 0.15 0.0122950819672131
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.0175067274556264 194 25 3 0.12 0.0154639175257732
GO:BP GO:0046782 regulation of viral transcription 0.0175067274556264 41 117 3 0.0256410256410256 0.0731707317073171
GO:BP GO:0009967 positive regulation of signal transduction 0.017512012723064 1598 76 15 0.197368421052632 0.00938673341677096
GO:BP GO:0002263 cell activation involved in immune response 0.0175284744764237 721 35 6 0.171428571428571 0.00832177531206657
GO:BP GO:0042063 gliogenesis 0.0177004785501203 308 55 5 0.0909090909090909 0.0162337662337662
GO:BP GO:0043270 positive regulation of ion transport 0.0177004785501203 694 62 8 0.129032258064516 0.0115273775216138
GO:BP GO:0031960 response to corticosteroid 0.0177004785501203 165 102 5 0.0490196078431373 0.0303030303030303
GO:BP GO:0042110 T cell activation 0.0177004785501203 489 51 6 0.117647058823529 0.0122699386503067
GO:BP GO:0002446 neutrophil mediated immunity 0.017990124057979 497 35 5 0.142857142857143 0.0100603621730382
GO:BP GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.017990124057979 59 83 3 0.036144578313253 0.0508474576271186
GO:BP GO:0051246 regulation of protein metabolic process 0.0180182419752535 2704 56 17 0.303571428571429 0.00628698224852071
GO:BP GO:0042116 macrophage activation 0.0182257258118543 110 45 3 0.0666666666666667 0.0272727272727273
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0182257258118543 1455 45 10 0.222222222222222 0.00687285223367698
GO:BP GO:0051098 regulation of binding 0.0182465569756201 365 29 4 0.137931034482759 0.010958904109589
GO:BP GO:0045087 innate immune response 0.0182465569756201 998 75 11 0.146666666666667 0.0110220440881764
GO:BP GO:0042098 T cell proliferation 0.0184983492070131 205 51 4 0.0784313725490196 0.0195121951219512
GO:BP GO:0072577 endothelial cell apoptotic process 0.0188981558083136 68 74 3 0.0405405405405405 0.0441176470588235
GO:BP GO:0051049 regulation of transport 0.0189025184333798 1809 62 14 0.225806451612903 0.00773908236594804
GO:BP GO:0060425 lung morphogenesis 0.0189025184333798 50 101 3 0.0297029702970297 0.06
GO:BP GO:0006953 acute-phase response 0.0193461158402926 50 102 3 0.0294117647058824 0.06
GO:BP GO:1904035 regulation of epithelial cell apoptotic process 0.0194380148088911 105 101 4 0.0396039603960396 0.0380952380952381
GO:BP GO:0002520 immune system development 0.0195314443813411 1020 44 8 0.181818181818182 0.00784313725490196
GO:BP GO:0048729 tissue morphogenesis 0.0196713745518405 667 81 9 0.111111111111111 0.0134932533733133
GO:BP GO:1901890 positive regulation of cell junction assembly 0.0196713745518405 97 110 4 0.0363636363636364 0.0412371134020619
GO:BP GO:0031334 positive regulation of protein-containing complex assembly 0.0196713745518405 263 97 6 0.0618556701030928 0.0228136882129278
GO:BP GO:0002252 immune effector process 0.019893506740046 1309 35 8 0.228571428571429 0.00611153552330023
GO:BP GO:2000379 positive regulation of reactive oxygen species metabolic process 0.020841553135943 107 102 4 0.0392156862745098 0.0373831775700935
GO:BP GO:0080135 regulation of cellular response to stress 0.0208878723505895 725 16 4 0.25 0.00551724137931034
GO:BP GO:0044093 positive regulation of molecular function 0.020922178066768 1771 92 18 0.195652173913043 0.0101637492941841
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.020922178066768 251 44 4 0.0909090909090909 0.0159362549800797
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.0210100857531673 1853 102 20 0.196078431372549 0.0107933081489477
GO:BP GO:1904036 negative regulation of epithelial cell apoptotic process 0.0210990418823397 53 101 3 0.0297029702970297 0.0566037735849057
GO:BP GO:0033627 cell adhesion mediated by integrin 0.0215201908413642 73 74 3 0.0405405405405405 0.0410958904109589
GO:BP GO:0030154 cell differentiation 0.0216447231093188 4350 59 24 0.406779661016949 0.00551724137931034
GO:BP GO:0043299 leukocyte degranulation 0.0220759953593904 535 35 5 0.142857142857143 0.00934579439252336
GO:BP GO:0048523 negative regulation of cellular process 0.0220759953593904 5139 30 16 0.533333333333333 0.00311344619575793
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0220759953593904 2541 56 16 0.285714285714286 0.00629673356946084
GO:BP GO:0006979 response to oxidative stress 0.0220759953593904 466 40 5 0.125 0.0107296137339056
GO:BP GO:0045601 regulation of endothelial cell differentiation 0.0221409845935683 50 110 3 0.0272727272727273 0.06
GO:BP GO:0007566 embryo implantation 0.0221901748799452 54 102 3 0.0294117647058824 0.0555555555555556
GO:BP GO:1903706 regulation of hemopoiesis 0.0222664777846311 424 44 5 0.113636363636364 0.0117924528301887
GO:BP GO:0002443 leukocyte mediated immunity 0.0222707983872093 877 76 10 0.131578947368421 0.0114025085518814
GO:BP GO:1903426 regulation of reactive oxygen species biosynthetic process 0.0224148842273075 111 102 4 0.0392156862745098 0.036036036036036
GO:BP GO:0006487 protein N-linked glycosylation 0.0224148842273075 76 73 3 0.0410958904109589 0.0394736842105263
GO:BP GO:0032602 chemokine production 0.0224148842273075 101 55 3 0.0545454545454545 0.0297029702970297
GO:BP GO:0009888 tissue development 0.022482745407625 2107 110 23 0.209090909090909 0.0109159943046986
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.022482745407625 223 83 5 0.0602409638554217 0.0224215246636771
GO:BP GO:0030099 myeloid cell differentiation 0.0227079973613562 428 44 5 0.113636363636364 0.0116822429906542
GO:BP GO:0072009 nephron epithelium development 0.0229664104497609 110 104 4 0.0384615384615385 0.0363636363636364
GO:BP GO:0001816 cytokine production 0.0231187398177512 844 55 8 0.145454545454545 0.00947867298578199
GO:BP GO:0048513 animal organ development 0.0231839032386692 3672 51 19 0.372549019607843 0.00517429193899782
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0232569354354939 547 35 5 0.142857142857143 0.00914076782449726
GO:BP GO:0048568 embryonic organ development 0.0233679406710943 432 44 5 0.113636363636364 0.0115740740740741
GO:BP GO:0016579 protein deubiquitination 0.0236020772783806 292 20 3 0.15 0.0102739726027397
GO:BP GO:0097305 response to alcohol 0.0236791023439975 255 74 5 0.0675675675675676 0.0196078431372549
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0237314811450667 551 35 5 0.142857142857143 0.00907441016333938
GO:BP GO:0042303 molting cycle 0.023795856965063 112 104 4 0.0384615384615385 0.0357142857142857
GO:BP GO:0042633 hair cycle 0.023795856965063 112 104 4 0.0384615384615385 0.0357142857142857
GO:BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 0.0241483149085402 269 44 4 0.0909090909090909 0.0148698884758364
GO:BP GO:0001666 response to hypoxia 0.0241606501282864 367 75 6 0.08 0.0163487738419619
GO:BP GO:0009620 response to fungus 0.0241606501282864 54 108 3 0.0277777777777778 0.0555555555555556
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0243310889088471 363 76 6 0.0789473684210526 0.0165289256198347
GO:BP GO:0045727 positive regulation of translation 0.0244942305311594 140 137 5 0.0364963503649635 0.0357142857142857
GO:BP GO:0002694 regulation of leukocyte activation 0.0244942305311594 610 46 6 0.130434782608696 0.00983606557377049
GO:BP GO:0071456 cellular response to hypoxia 0.0247258405405132 212 130 6 0.0461538461538462 0.0283018867924528
GO:BP GO:0046883 regulation of hormone secretion 0.0249863938465536 275 44 4 0.0909090909090909 0.0145454545454545
GO:BP GO:0042542 response to hydrogen peroxide 0.0249863938465536 150 40 3 0.075 0.02
GO:BP GO:0045732 positive regulation of protein catabolic process 0.0249863938465536 237 51 4 0.0784313725490196 0.0168776371308017
GO:BP GO:0043523 regulation of neuron apoptotic process 0.0251570524846443 216 56 4 0.0714285714285714 0.0185185185185185
GO:BP GO:0003006 developmental process involved in reproduction 0.0254074195660167 982 49 8 0.163265306122449 0.00814663951120163
GO:BP GO:0033043 regulation of organelle organization 0.0254074195660167 1203 58 10 0.172413793103448 0.00831255195344971
GO:BP GO:0070646 protein modification by small protein removal 0.0255320724969151 310 20 3 0.15 0.00967741935483871
GO:BP GO:0033135 regulation of peptidyl-serine phosphorylation 0.0257665528311935 146 134 5 0.0373134328358209 0.0342465753424658
GO:BP GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 0.0257665528311935 63 97 3 0.0309278350515464 0.0476190476190476
GO:BP GO:0010628 positive regulation of gene expression 0.0257665528311935 1160 51 9 0.176470588235294 0.00775862068965517
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0257665528311935 783 88 10 0.113636363636364 0.0127713920817369
GO:BP GO:0034599 cellular response to oxidative stress 0.0260569075612343 316 20 3 0.15 0.00949367088607595
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.0260569075612343 152 130 5 0.0384615384615385 0.0328947368421053
GO:BP GO:0045785 positive regulation of cell adhesion 0.0260569075612343 437 46 5 0.108695652173913 0.011441647597254
GO:BP GO:0030001 metal ion transport 0.026573783332673 514 74 7 0.0945945945945946 0.0136186770428016
GO:BP GO:0001819 positive regulation of cytokine production 0.0270792967277682 452 45 5 0.111111111111111 0.0110619469026549
GO:BP GO:1902105 regulation of leukocyte differentiation 0.0272349200938904 288 44 4 0.0909090909090909 0.0138888888888889
GO:BP GO:0009991 response to extracellular stimulus 0.0272349200938904 512 40 5 0.125 0.009765625
GO:BP GO:0007565 female pregnancy 0.0276587538541759 198 102 5 0.0490196078431373 0.0252525252525253
GO:BP GO:0065007 biological regulation 0.0277370005480321 12809 48 42 0.875 0.00327894449215395
GO:BP GO:0034284 response to monosaccharide 0.0277370005480321 215 30 3 0.1 0.013953488372093
GO:BP GO:0016032 viral process 0.0277370005480321 942 75 10 0.133333333333333 0.0106157112526539
GO:BP GO:0070997 neuron death 0.0277574828316041 365 56 5 0.0892857142857143 0.0136986301369863
GO:BP GO:0042592 homeostatic process 0.0287520577736832 1981 74 16 0.216216216216216 0.00807672892478546
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 0.0287921525413769 88 74 3 0.0405405405405405 0.0340909090909091
GO:BP GO:1904019 epithelial cell apoptotic process 0.0292310041886242 128 101 4 0.0396039603960396 0.03125
GO:BP GO:2000377 regulation of reactive oxygen species metabolic process 0.0295861726467213 203 102 5 0.0490196078431373 0.0246305418719212
GO:BP GO:0022414 reproductive process 0.0298782041352929 1493 49 10 0.204081632653061 0.00669792364367046
GO:BP GO:0050865 regulation of cell activation 0.0301616503261534 655 46 6 0.130434782608696 0.00916030534351145
GO:BP GO:0000003 reproduction 0.0301641072657604 1496 49 10 0.204081632653061 0.00668449197860963
GO:BP GO:0044070 regulation of anion transport 0.0301648840020766 896 56 8 0.142857142857143 0.00892857142857143
GO:BP GO:0070671 response to interleukin-12 0.0302575827243323 50 134 3 0.0223880597014925 0.06
GO:BP GO:0051926 negative regulation of calcium ion transport 0.0306101733215817 66 102 3 0.0294117647058824 0.0454545454545455
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 0.0306282967139299 2555 44 13 0.295454545454545 0.0050880626223092
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 0.0308878475869648 686 73 8 0.10958904109589 0.0116618075801749
GO:BP GO:0042129 regulation of T cell proliferation 0.0312982663519986 176 39 3 0.0769230769230769 0.0170454545454545
GO:BP GO:0043269 regulation of ion transport 0.0312982663519986 1379 79 13 0.164556962025316 0.00942712110224801
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.0318789072551394 309 44 4 0.0909090909090909 0.0129449838187702
GO:BP GO:0045428 regulation of nitric oxide biosynthetic process 0.0320730353239763 68 102 3 0.0294117647058824 0.0441176470588235
GO:BP GO:2000026 regulation of multicellular organismal development 0.0320946441802689 1447 29 7 0.241379310344828 0.00483759502418798
GO:BP GO:0050790 regulation of catalytic activity 0.032630771780139 2545 102 24 0.235294117647059 0.00943025540275049
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.0330555994988622 966 76 10 0.131578947368421 0.010351966873706
GO:BP GO:0051336 regulation of hydrolase activity 0.0331766919609525 1321 102 15 0.147058823529412 0.0113550340651022
GO:BP GO:0008637 apoptotic mitochondrial changes 0.0331766919609525 126 56 3 0.0535714285714286 0.0238095238095238
GO:BP GO:1903409 reactive oxygen species biosynthetic process 0.033698500316691 135 102 4 0.0392156862745098 0.0296296296296296
GO:BP GO:0062197 cellular response to chemical stress 0.033698500316691 365 20 3 0.15 0.00821917808219178
GO:BP GO:0080164 regulation of nitric oxide metabolic process 0.033698500316691 70 102 3 0.0294117647058824 0.0428571428571429
GO:BP GO:0046879 hormone secretion 0.033698500316691 317 44 4 0.0909090909090909 0.0126182965299685
GO:BP GO:0051402 neuron apoptotic process 0.0341668469227833 250 56 4 0.0714285714285714 0.016
GO:BP GO:0009743 response to carbohydrate 0.0341668469227833 243 30 3 0.1 0.0123456790123457
GO:BP GO:0051493 regulation of cytoskeleton organization 0.0349403311557996 531 97 8 0.0824742268041237 0.0150659133709981
GO:BP GO:0032388 positive regulation of intracellular transport 0.0350385912234302 229 136 6 0.0441176470588235 0.0262008733624454
GO:BP GO:0032680 regulation of tumor necrosis factor production 0.0350385912234302 163 45 3 0.0666666666666667 0.0184049079754601
GO:BP GO:0030216 keratinocyte differentiation 0.0353261809069949 304 135 7 0.0518518518518519 0.0230263157894737
GO:BP GO:1901888 regulation of cell junction assembly 0.0353261809069949 202 110 5 0.0454545454545455 0.0247524752475248
GO:BP GO:0032675 regulation of interleukin-6 production 0.0354029760692074 168 44 3 0.0681818181818182 0.0178571428571429
GO:BP GO:0045598 regulation of fat cell differentiation 0.0354661242154383 139 102 4 0.0392156862745098 0.0287769784172662
GO:BP GO:0032640 tumor necrosis factor production 0.0355635289420835 165 45 3 0.0666666666666667 0.0181818181818182
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0357660763312403 1001 75 10 0.133333333333333 0.00999000999000999
GO:BP GO:0030162 regulation of proteolysis 0.0362361644644607 752 56 7 0.125 0.00930851063829787
GO:BP GO:0007162 negative regulation of cell adhesion 0.0362645090841158 304 25 3 0.12 0.00986842105263158
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.0363701973635508 167 45 3 0.0666666666666667 0.0179640718562874
GO:BP GO:0050789 regulation of biological process 0.036612536646141 12091 48 40 0.833333333333333 0.00330824580266314
GO:BP GO:0032635 interleukin-6 production 0.0367554907266809 172 44 3 0.0681818181818182 0.0174418604651163
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 0.0367659959814781 111 130 4 0.0307692307692308 0.036036036036036
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.0375434988980478 170 45 3 0.0666666666666667 0.0176470588235294
GO:BP GO:0006816 calcium ion transport 0.0376625735419213 436 74 6 0.0810810810810811 0.0137614678899083
GO:BP GO:0033138 positive regulation of peptidyl-serine phosphorylation 0.0376625735419213 109 134 4 0.0298507462686567 0.036697247706422
GO:BP GO:0031667 response to nutrient levels 0.0376625735419213 482 31 4 0.129032258064516 0.00829875518672199
GO:BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 0.0376625735419213 198 74 4 0.0540540540540541 0.0202020202020202
GO:BP GO:0002521 leukocyte differentiation 0.0376625735419213 550 59 6 0.101694915254237 0.0109090909090909
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0378722002989233 982 44 7 0.159090909090909 0.00712830957230143
GO:BP GO:0072006 nephron development 0.0383535797761129 142 104 4 0.0384615384615385 0.028169014084507
GO:BP GO:0006446 regulation of translational initiation 0.0383535797761129 80 97 3 0.0309278350515464 0.0375
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.0383843340002813 241 134 6 0.0447761194029851 0.024896265560166
GO:BP GO:0044706 multi-multicellular organism process 0.038776088704026 227 102 5 0.0490196078431373 0.0220264317180617
GO:BP GO:0045639 positive regulation of myeloid cell differentiation 0.0389271362357235 103 76 3 0.0394736842105263 0.029126213592233
GO:BP GO:1903364 positive regulation of cellular protein catabolic process 0.0389482993631825 154 51 3 0.0588235294117647 0.0194805194805195
GO:BP GO:0031323 regulation of cellular metabolic process 0.0393676771095435 6269 48 25 0.520833333333333 0.00398787685436274
GO:BP GO:0061138 morphogenesis of a branching epithelium 0.039620595289698 181 44 3 0.0681818181818182 0.0165745856353591
GO:BP GO:1901654 response to ketone 0.0397315690419931 204 74 4 0.0540540540540541 0.0196078431372549
GO:BP GO:0070268 cornification 0.0401691936734536 112 135 4 0.0296296296296296 0.0357142857142857
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 0.0407313889438902 117 130 4 0.0307692307692308 0.0341880341880342
GO:BP GO:0007160 cell-matrix adhesion 0.0418588367561247 235 35 3 0.0857142857142857 0.0127659574468085
GO:BP GO:1905897 regulation of response to endoplasmic reticulum stress 0.0418588367561247 84 97 3 0.0309278350515464 0.0357142857142857
GO:BP GO:0050863 regulation of T cell activation 0.0418588367561247 337 46 4 0.0869565217391304 0.0118694362017804
GO:BP GO:0010638 positive regulation of organelle organization 0.042166851598461 603 56 6 0.107142857142857 0.00995024875621891
GO:BP GO:0006355 regulation of transcription, DNA-templated 0.042166851598461 3534 24 10 0.416666666666667 0.00282965478211658
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 0.042166851598461 3535 24 10 0.416666666666667 0.00282885431400283
GO:BP GO:0006366 transcription by RNA polymerase II 0.042166851598461 2723 44 13 0.295454545454545 0.00477414616232097
GO:BP GO:2001141 regulation of RNA biosynthetic process 0.0425215079468138 3540 24 10 0.416666666666667 0.00282485875706215
GO:BP GO:0034504 protein localization to nucleus 0.0429717995255848 289 29 3 0.103448275862069 0.0103806228373702
GO:BP GO:0048863 stem cell differentiation 0.0429848965966584 258 130 6 0.0461538461538462 0.0232558139534884
GO:BP GO:0014032 neural crest cell development 0.0433483950356845 80 104 3 0.0288461538461538 0.0375
GO:BP GO:0001822 kidney development 0.0434509792938578 293 29 3 0.103448275862069 0.0102389078498294
GO:BP GO:0006809 nitric oxide biosynthetic process 0.0434509792938578 82 102 3 0.0294117647058824 0.0365853658536585
GO:BP GO:0043242 negative regulation of protein-containing complex disassembly 0.0434509792938578 86 97 3 0.0309278350515464 0.0348837209302326
GO:BP GO:0006766 vitamin metabolic process 0.0434905479151483 131 120 4 0.0333333333333333 0.0305343511450382
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.0445547892870005 215 74 4 0.0540540540540541 0.0186046511627907
GO:BP GO:0043200 response to amino acid 0.0446087298048971 115 74 3 0.0405405405405405 0.0260869565217391
GO:BP GO:0001763 morphogenesis of a branching structure 0.0449723590252406 195 44 3 0.0681818181818182 0.0153846153846154
GO:BP GO:0043254 regulation of protein-containing complex assembly 0.0449723590252406 460 97 7 0.0721649484536082 0.0152173913043478
GO:BP GO:0050890 cognition 0.0452108454214557 298 115 6 0.0521739130434783 0.0201342281879195
GO:BP GO:0043085 positive regulation of catalytic activity 0.0455218280583943 1418 92 14 0.152173913043478 0.00987306064880113
GO:BP GO:0072001 renal system development 0.0458647927890908 302 29 3 0.103448275862069 0.00993377483443709
GO:BP GO:0034248 regulation of cellular amide metabolic process 0.0458647927890908 535 47 5 0.106382978723404 0.00934579439252336
GO:BP GO:0048864 stem cell development 0.046751410593664 84 104 3 0.0288461538461538 0.0357142857142857
GO:BP GO:0014031 mesenchymal cell development 0.046751410593664 84 104 3 0.0288461538461538 0.0357142857142857
GO:BP GO:0008406 gonad development 0.0472628813954815 221 74 4 0.0540540540540541 0.0180995475113122
GO:BP GO:0070830 bicellular tight junction assembly 0.0472628813954815 80 110 3 0.0272727272727273 0.0375
GO:BP GO:1905952 regulation of lipid localization 0.0472628813954815 201 44 3 0.0681818181818182 0.0149253731343284
GO:BP GO:0009101 glycoprotein biosynthetic process 0.0480750832640426 347 73 5 0.0684931506849315 0.0144092219020173
GO:BP GO:0055085 transmembrane transport 0.0480998382570751 1635 89 15 0.168539325842697 0.00917431192660551
GO:BP GO:0046209 nitric oxide metabolic process 0.0480998382570751 87 102 3 0.0294117647058824 0.0344827586206897
GO:BP GO:0090316 positive regulation of intracellular protein transport 0.0481906351905399 186 136 5 0.0367647058823529 0.0268817204301075
GO:BP GO:0007267 cell-cell signaling 0.0481906351905399 1722 55 11 0.2 0.00638792102206736
GO:BP GO:0051046 regulation of secretion 0.0485189944462805 647 55 6 0.109090909090909 0.00927357032457496
GO:BP GO:0001942 hair follicle development 0.0485189944462805 86 104 3 0.0288461538461538 0.0348837209302326
GO:BP GO:0097553 calcium ion transmembrane import into cytosol 0.048636654484904 145 62 3 0.0483870967741935 0.0206896551724138
GO:BP GO:2001057 reactive nitrogen species metabolic process 0.048636654484904 88 102 3 0.0294117647058824 0.0340909090909091
GO:BP GO:0046889 positive regulation of lipid biosynthetic process 0.048636654484904 88 102 3 0.0294117647058824 0.0340909090909091
GO:BP GO:0034976 response to endoplasmic reticulum stress 0.0486577389716233 298 56 4 0.0714285714285714 0.0134228187919463
GO:BP GO:1903530 regulation of secretion by cell 0.0488217050512995 588 44 5 0.113636363636364 0.00850340136054422
GO:BP GO:0120192 tight junction assembly 0.0489344075172308 82 110 3 0.0272727272727273 0.0365853658536585
GO:BP GO:0031326 regulation of cellular biosynthetic process 0.0493766114559094 4273 24 11 0.458333333333333 0.00257430376784461
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.049725557766162 385 44 4 0.0909090909090909 0.0103896103896104
GO:BP GO:0045137 development of primary sexual characteristics 0.049725557766162 227 74 4 0.0540540540540541 0.0176211453744493
GO:BP GO:0043271 negative regulation of ion transport 0.0498212569860171 349 102 6 0.0588235294117647 0.0171919770773639
GO:BP GO:0001817 regulation of cytokine production 0.049934732298289 806 45 6 0.133333333333333 0.00744416873449132
GO:CC GO:0033256 I-kappaB/NF-kappaB complex 1.37654562759367e-05 4 42 3 0.0714285714285714 0.75
GO:CC GO:0005615 extracellular space 0.000196330597052603 3594 39 21 0.538461538461538 0.00584307178631052
GO:CC GO:0005576 extracellular region 0.00508935146596678 4567 39 21 0.538461538461538 0.00459820451061966
GO:CC GO:0005640 nuclear outer membrane 0.0462477396021702 28 119 3 0.0252100840336134 0.107142857142857
GO:MF GO:0008009 chemokine activity 4.69574680151733e-11 49 5 5 1 0.102040816326531
GO:MF GO:0042379 chemokine receptor binding 1.72272534633174e-10 72 5 5 1 0.0694444444444444
GO:MF GO:0045236 CXCR chemokine receptor binding 4.68717130942571e-10 18 5 4 0.8 0.222222222222222
GO:MF GO:0005125 cytokine activity 3.52272518844171e-08 235 5 5 1 0.0212765957446809
GO:MF GO:0005126 cytokine receptor binding 6.22319263962439e-08 275 5 5 1 0.0181818181818182
GO:MF GO:0001664 G protein-coupled receptor binding 7.01474792108696e-08 292 5 5 1 0.0171232876712329
GO:MF GO:0050786 RAGE receptor binding 1.7622803782809e-07 11 108 5 0.0462962962962963 0.454545454545455
GO:MF GO:0048018 receptor ligand activity 7.05424677745014e-07 494 5 5 1 0.0101214574898785
GO:MF GO:0030546 signaling receptor activator activity 7.05424677745014e-07 501 5 5 1 0.00998003992015968
GO:MF GO:0030545 receptor regulator activity 9.68703644744276e-07 545 5 5 1 0.00917431192660551
GO:MF GO:0005102 signaling receptor binding 9.75613093819742e-07 1672 55 20 0.363636363636364 0.0119617224880383
GO:MF GO:0048306 calcium-dependent protein binding 0.000309513325732677 82 108 6 0.0555555555555556 0.0731707317073171
GO:MF GO:0098772 molecular function regulator 0.00115807142077703 2363 5 5 1 0.00211595429538722
GO:MF GO:0016209 antioxidant activity 0.00142013360276015 87 15 3 0.2 0.0344827586206897
GO:MF GO:0140297 DNA-binding transcription factor binding 0.00603507144072528 391 28 5 0.178571428571429 0.0127877237851662
GO:MF GO:0008134 transcription factor binding 0.00929836004964007 676 28 6 0.214285714285714 0.00887573964497041
GO:MF GO:0042802 identical protein binding 0.0111736783499715 2067 28 10 0.357142857142857 0.00483792936623125
GO:MF GO:0031369 translation initiation factor binding 0.0128539626290746 34 97 3 0.0309278350515464 0.0882352941176471
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.0128539626290746 281 28 4 0.142857142857143 0.0142348754448399
GO:MF GO:0046875 ephrin receptor binding 0.0142581770339384 29 139 3 0.0215827338129496 0.103448275862069
GO:MF GO:0003779 actin binding 0.0258324908344858 448 122 9 0.0737704918032787 0.0200892857142857
GO:MF GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 0.0293361575570571 451 42 5 0.119047619047619 0.0110864745011086
GO:MF GO:0001216 DNA-binding transcription activator activity 0.0293361575570571 455 42 5 0.119047619047619 0.010989010989011
GO:MF GO:0046914 transition metal ion binding 0.0293361575570571 1111 34 7 0.205882352941176 0.0063006300630063
KEGG KEGG:04657 IL-17 signaling pathway 1.36429303812411e-13 92 55 14 0.254545454545455 0.152173913043478
KEGG KEGG:04668 TNF signaling pathway 7.35005779619914e-11 112 46 12 0.260869565217391 0.107142857142857
KEGG KEGG:05323 Rheumatoid arthritis 8.66118784886879e-09 88 5 5 1 0.0568181818181818
KEGG KEGG:04061 Viral protein interaction with cytokine and cytokine receptor 1.12605767609065e-08 98 5 5 1 0.0510204081632653
KEGG KEGG:04064 NF-kappa B signaling pathway 1.10306717496107e-07 102 44 9 0.204545454545455 0.0882352941176471
KEGG KEGG:05134 Legionellosis 1.13513036852223e-07 57 10 5 0.5 0.087719298245614
KEGG KEGG:04062 Chemokine signaling pathway 1.85408606568517e-07 190 5 5 1 0.0263157894736842
KEGG KEGG:05120 Epithelial cell signaling in Helicobacter pylori infection 2.44415074688168e-07 70 10 5 0.5 0.0714285714285714
KEGG KEGG:04060 Cytokine-cytokine receptor interaction 1.28143598877982e-06 293 5 5 1 0.0170648464163823
KEGG KEGG:04621 NOD-like receptor signaling pathway 1.3744684086168e-06 177 27 8 0.296296296296296 0.0451977401129944
KEGG KEGG:05146 Amoebiasis 1.94963075603043e-06 101 5 4 0.8 0.0396039603960396
KEGG KEGG:05167 Kaposi sarcoma-associated herpesvirus infection 1.80057425124363e-05 193 16 6 0.375 0.0310880829015544
KEGG KEGG:04380 Osteoclast differentiation 0.000887911256082267 125 45 6 0.133333333333333 0.048
KEGG KEGG:04625 C-type lectin receptor signaling pathway 0.0277535631287066 104 44 4 0.0909090909090909 0.0384615384615385
KEGG KEGG:05142 Chagas disease 0.0277535631287066 101 45 4 0.0888888888888889 0.0396039603960396
KEGG KEGG:05164 Influenza A 0.0277535631287066 169 45 5 0.111111111111111 0.029585798816568
KEGG KEGG:04620 Toll-like receptor signaling pathway 0.0286884094910197 102 46 4 0.0869565217391304 0.0392156862745098
KEGG KEGG:05160 Hepatitis C 0.0309953344492606 157 75 6 0.08 0.0382165605095541
KEGG KEGG:05161 Hepatitis B 0.0323965484620903 162 16 3 0.1875 0.0185185185185185
KEGG KEGG:05169 Epstein-Barr virus infection 0.0360058958035094 198 44 5 0.113636363636364 0.0252525252525253
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 0.0476239816481676 216 44 5 0.113636363636364 0.0231481481481481
KEGG KEGG:04920 Adipocytokine signaling pathway 0.0476239816481676 69 44 3 0.0681818181818182 0.0434782608695652
MIRNA MIRNA:hsa-miR-4662b hsa-miR-4662b 0.0021135984101572 97 18 4 0.222222222222222 0.0412371134020619
MIRNA MIRNA:hsa-miR-4426 hsa-miR-4426 0.0021135984101572 97 18 4 0.222222222222222 0.0412371134020619
MIRNA MIRNA:hsa-miR-4647 hsa-miR-4647 0.0021135984101572 97 18 4 0.222222222222222 0.0412371134020619
MIRNA MIRNA:hsa-miR-98-5p hsa-miR-98-5p 0.00410723262310747 778 79 15 0.189873417721519 0.019280205655527
MIRNA MIRNA:hsa-miR-1-3p hsa-miR-1-3p 0.0177020955330567 915 5 4 0.8 0.00437158469945355
REAC REAC:R-HSA-380108 Chemokine receptors bind chemokines 2.06170921242645e-09 57 5 5 1 0.087719298245614
REAC REAC:R-HSA-6783783 Interleukin-10 signaling 3.66217590959559e-07 45 5 4 0.8 0.0888888888888889
REAC REAC:R-HSA-375276 Peptide ligand-binding receptors 3.66217590959559e-07 195 5 5 1 0.0256410256410256
REAC REAC:R-HSA-449147 Signaling by Interleukins 4.83793706928735e-07 446 108 21 0.194444444444444 0.047085201793722
REAC REAC:R-HSA-373076 Class A/1 (Rhodopsin-like receptors) 3.0215499160893e-06 328 5 5 1 0.0152439024390244
REAC REAC:R-HSA-418594 G alpha (i) signalling events 6.91563077066683e-06 401 5 5 1 0.0124688279301746
REAC REAC:R-HSA-500792 GPCR ligand binding 1.16843557902432e-05 459 5 5 1 0.0108932461873638
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 3.47785411099623e-05 842 54 17 0.314814814814815 0.0201900237529691
REAC REAC:R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 7.51912625846011e-05 110 104 9 0.0865384615384615 0.0818181818181818
REAC REAC:R-HSA-6799990 Metal sequestration by antimicrobial proteins 0.000141907554000822 6 55 3 0.0545454545454545 0.5
REAC REAC:R-HSA-388396 GPCR downstream signalling 0.000563490774101234 1088 5 5 1 0.00459558823529412
REAC REAC:R-HSA-372790 Signaling by GPCR 0.000705892405291937 1158 5 5 1 0.00431778929188256
REAC REAC:R-HSA-168256 Immune System 0.00294535992180958 2139 55 24 0.436363636363636 0.0112201963534362
REAC REAC:R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 0.00959702920982282 24 55 3 0.0545454545454545 0.125
REAC REAC:R-HSA-9020702 Interleukin-1 signaling 0.00974320560003886 101 134 7 0.0522388059701493 0.0693069306930693
REAC REAC:R-HSA-162582 Signal Transduction 0.00974320560003886 2705 6 6 1 0.0022181146025878
REAC REAC:R-HSA-381042 PERK regulates gene expression 0.0126272277814224 32 49 3 0.0612244897959184 0.09375
REAC REAC:R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 0.0191324240881393 32 134 4 0.0298507462686567 0.125
REAC REAC:R-HSA-197264 Nicotinamide salvaging 0.0203241282637304 19 102 3 0.0294117647058824 0.157894736842105
REAC REAC:R-HSA-168898 Toll-like Receptor Cascades 0.024440533219891 152 55 5 0.0909090909090909 0.0328947368421053
REAC REAC:R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 0.0281938214192374 21 117 3 0.0256410256410256 0.142857142857143
REAC REAC:R-HSA-933542 TRAF6 mediated NF-kB activation 0.0321512907550657 24 108 3 0.0277777777777778 0.125
REAC REAC:R-HSA-446652 Interleukin-1 family signaling 0.0321512907550657 138 134 7 0.0522388059701493 0.0507246376811594
REAC REAC:R-HSA-196807 Nicotinate metabolism 0.0456188797431631 31 102 3 0.0294117647058824 0.0967741935483871
REAC REAC:R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 0.0462395474967635 76 42 3 0.0714285714285714 0.0394736842105263
TF TF:M03563_1 Factor: RelA-p65; motif: GGGANTTTCCNN; match class: 1 0.000322863569774122 876 25 10 0.4 0.0114155251141553
TF TF:M00052 Factor: NF-kappaB; motif: GGGRATTTCC 0.00155623132643774 1874 6 6 1 0.0032017075773746
TF TF:M00053_1 Factor: c-Rel; motif: SGGRNTTTCC; match class: 1 0.00155623132643774 426 25 7 0.28 0.0164319248826291
TF TF:M08952_1 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN; match class: 1 0.00218069584675311 3457 65 28 0.430769230769231 0.00809950824414232
TF TF:M00051 Factor: NF-kappaB; motif: GGGGATYCCC 0.00242754661301578 6413 130 68 0.523076923076923 0.0106034617183845
TF TF:M00194_1 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN; match class: 1 0.00242754661301578 385 21 6 0.285714285714286 0.0155844155844156
TF TF:M04706_1 Factor: RelA; motif: GGGRAWTYC; match class: 1 0.00251799219422545 344 14 5 0.357142857142857 0.0145348837209302
TF TF:M07221 Factor: NF-kappaB1; motif: KGGRNTTTCCM 0.00252726363258807 2417 6 6 1 0.00248241621845263
TF TF:M10094_1 Factor: RelA-p65; motif: NWGGGRATTTCCMN; match class: 1 0.00252726363258807 242 20 5 0.25 0.0206611570247934
TF TF:M00054_1 Factor: NF-kappaB; motif: GGGAMTTYCC; match class: 1 0.00370324977662628 712 21 7 0.333333333333333 0.0098314606741573
TF TF:M03545_1 Factor: c-Rel; motif: NGGGAATYTCCN; match class: 1 0.00398834524707683 1011 4 4 1 0.0039564787339268
TF TF:M10004 Factor: NF-kappaB2; motif: GGGRAANYCCC 0.00455767230652262 1073 4 4 1 0.00372786579683131
TF TF:M00469 Factor: AP-2alpha; motif: GCCNNNRGS 0.00455767230652262 5147 113 51 0.451327433628319 0.00990868467068195
TF TF:M04259 Factor: FOXO3; motif: GTAAACAW 0.00474772463808266 2079 5 5 1 0.00240500240500241
TF TF:M07989 Factor: FOXG1; motif: RTAAACAW 0.00474772463808266 1188 4 4 1 0.00336700336700337
TF TF:M11498_1 Factor: OC-2; motif: NNATCGATYN; match class: 1 0.00474772463808266 396 27 6 0.222222222222222 0.0151515151515152
TF TF:M12227_1 Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 0.00474772463808266 5898 84 44 0.523809523809524 0.00746015598507969
TF TF:M04247 Factor: FOXJ2; motif: RTAAACAA 0.00474772463808266 1188 4 4 1 0.00336700336700337
TF TF:M09805 Factor: FOXK1; motif: NNNGTAAACANGNN 0.00667893070044236 890 5 4 0.8 0.00449438202247191
TF TF:M00646_1 Factor: LF-A1; motif: GGGSTCWR; match class: 1 0.00869457915734631 6320 81 44 0.54320987654321 0.0069620253164557
TF TF:M03563 Factor: RelA-p65; motif: GGGANTTTCCNN 0.00997758048279691 4643 21 14 0.666666666666667 0.00301529183717424
TF TF:M00470 Factor: AP-2gamma; motif: GCCYNNGGS 0.010063135048632 9422 114 76 0.666666666666667 0.00806622797707493
TF TF:M00053 Factor: c-Rel; motif: SGGRNTTTCC 0.0112354807638505 3672 6 6 1 0.00163398692810458
TF TF:M11508_1 Factor: CDP; motif: NNATYGATYN; match class: 1 0.0112354807638505 1591 4 4 1 0.00251414204902577
TF TF:M00474 Factor: FOXO1; motif: GNNTTGTTTACNTT 0.0122843103020065 2777 5 5 1 0.00180050414115952
TF TF:M11582 Factor: FOXI1; motif: AAYRTAAACAAT 0.0122843103020065 1155 5 4 0.8 0.00346320346320346
TF TF:M03878 Factor: MIBP1; motif: WNWCCCCAGCTR 0.0122843103020065 2793 70 23 0.328571428571429 0.00823487289652703
TF TF:M01298 Factor: MECP2; motif: CCGGSNNNANNAWWT 0.0122843103020065 1290 8 5 0.625 0.00387596899224806
TF TF:M00800_1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 0.0122843103020065 4268 134 49 0.365671641791045 0.0114807872539831
TF TF:M00290 Factor: Freac-2; motif: NNANNGTAAACAANNN 0.0122843103020065 2798 5 5 1 0.00178699070764832
TF TF:M11340 Factor: MafF; motif: NTGCTGASTCAGCAN 0.0124042983991858 580 106 12 0.113207547169811 0.0206896551724138
TF TF:M11606 Factor: LEF-1; motif: ASATCAAAG 0.0124042983991858 6098 11 10 0.909090909090909 0.00163988192850115
TF TF:M01261 Factor: HNF3A; motif: RWGTAAACAN 0.0124042983991858 2840 5 5 1 0.00176056338028169
TF TF:M11611 Factor: LEF-1; motif: ASATCAAAG 0.0124042983991858 3517 13 9 0.692307692307692 0.00255899914700028
TF TF:M09932 Factor: FOXO3a; motif: NYTGTTTACN 0.0124042983991858 2895 5 5 1 0.00172711571675302
TF TF:M00774 Factor: NF-kappaB; motif: NGGGANTTYCCMNNNN 0.0124841011074119 1818 4 4 1 0.0022002200220022
TF TF:M07325_1 Factor: MaFA; motif: TCTGCTGASCNN; match class: 1 0.0124841011074119 522 4 3 0.75 0.00574712643678161
TF TF:M00054 Factor: NF-kappaB; motif: GGGAMTTYCC 0.0135506522797652 2444 21 10 0.476190476190476 0.00409165302782324
TF TF:M12215 Factor: GLIS1; motif: NACCCCCCACGNNGN 0.0144236495312164 596 123 13 0.105691056910569 0.0218120805369128
TF TF:M05445_1 Factor: GATA-5; motif: TTAMCAR; match class: 1 0.0144236495312164 414 5 3 0.6 0.0072463768115942
TF TF:M11604 Factor: LEF-1; motif: ASATCAAAG 0.0157299529701001 3714 13 9 0.692307692307692 0.0024232633279483
TF TF:M07368_1 Factor: Smad4; motif: NCAGACAN; match class: 1 0.0169210998241102 503 44 7 0.159090909090909 0.0139165009940358
TF TF:M03557_1 Factor: P50; motif: GGRRANTCCCNN; match class: 1 0.0169479269113443 1292 31 9 0.290322580645161 0.00696594427244582
TF TF:M03545 Factor: c-Rel; motif: NGGGAATYTCCN 0.0188758673257368 5530 7 7 1 0.00126582278481013
TF TF:M11940_1 Factor: POU4F3; motif: TNATGCATNA; match class: 1 0.0188758673257368 644 4 3 0.75 0.0046583850931677
TF TF:M03557 Factor: P50; motif: GGRRANTCCCNN 0.019327436253518 4967 42 22 0.523809523809524 0.00442923293738675
TF TF:M07429_1 Factor: SMAD3; motif: CAGACAS; match class: 1 0.0226176596553912 1381 44 11 0.25 0.00796524257784214
TF TF:M00339_1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 1 0.0235125272992893 1466 9 5 0.555555555555556 0.0034106412005457
TF TF:M04255 Factor: FOXO1; motif: GTAAACAW 0.0235125272992893 3720 5 5 1 0.00134408602150538
TF TF:M11741 Factor: COUP-TF1; motif: RRGGTCRNTGACCYY 0.0235125272992893 3249 95 30 0.315789473684211 0.00923361034164358
TF TF:M09912_1 Factor: c-Ets-2; motif: NNNRGGAARNRRR; match class: 1 0.0235125272992893 2450 136 32 0.235294117647059 0.0130612244897959
TF TF:M12010 Factor: SKOR1; motif: NWNMKGTAATTAMN 0.0235125272992893 183 130 7 0.0538461538461538 0.0382513661202186
TF TF:M01224 Factor: P50:RELA-P65; motif: GGANTTYCCCWN 0.0235125272992893 2329 4 4 1 0.0017174753112924
TF TF:M10094 Factor: RelA-p65; motif: NWGGGRATTTCCMN 0.0235125272992893 2429 4 4 1 0.0016467682173734
TF TF:M11609 Factor: LEF-1; motif: ASATCAAAG 0.0235125272992893 3078 13 8 0.615384615384615 0.00259909031838856
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.0235125272992893 10023 133 88 0.661654135338346 0.0087798064451761
TF TF:M00051_1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 1 0.0235125272992893 2797 125 33 0.264 0.0117983553807651
TF TF:M04265 Factor: FOXO6; motif: GTAAACA 0.0235125272992893 3720 5 5 1 0.00134408602150538
TF TF:M04244 Factor: FOXI1; motif: GTAAACA 0.0235125272992893 3720 5 5 1 0.00134408602150538
TF TF:M02033 Factor: TCF-4; motif: ATCAAAGNNN 0.0235125272992893 632 18 5 0.277777777777778 0.00791139240506329
TF TF:M04267 Factor: FOXP3; motif: RTAAACA 0.0235125272992893 3720 5 5 1 0.00134408602150538
TF TF:M01837 Factor: FKLF; motif: BGGGNGGVMD 0.0235125272992893 5442 30 18 0.6 0.00330760749724366
TF TF:M04253 Factor: FOXL1; motif: RTAAACA 0.0235125272992893 3720 5 5 1 0.00134408602150538
TF TF:M04239 Factor: FOXD2; motif: GTAAACA 0.0235125272992893 3720 5 5 1 0.00134408602150538
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.024006162923889 13173 66 57 0.863636363636364 0.00432703256661353
TF TF:M11508 Factor: CDP; motif: NNATYGATYN 0.024006162923889 3768 5 5 1 0.00132696390658174
TF TF:M01224_1 Factor: P50:RELA-P65; motif: GGANTTYCCCWN; match class: 1 0.024006162923889 236 74 6 0.0810810810810811 0.0254237288135593
TF TF:M08835 Factor: ZNF515; motif: WNSCCCCCWGCNG 0.024006162923889 3537 81 28 0.345679012345679 0.00791631325982471
TF TF:M00733_1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 1 0.0241748299643467 2823 125 33 0.264 0.0116896918172157
TF TF:M11745_1 Factor: COUP-TF1; motif: RAGGTCANTGACCTY; match class: 1 0.0241748299643467 1954 87 20 0.229885057471264 0.0102354145342886
TF TF:M04863_1 Factor: TF3C-beta; motif: CCNGGAGGGCTTCCTGGAGGAG; match class: 1 0.0241748299643467 8573 123 73 0.59349593495935 0.00851510556397994
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0241748299643467 9106 84 55 0.654761904761905 0.00603997364375137
TF TF:M11580 Factor: FOXI1; motif: NWANNGTAAACAA 0.024788257750735 1302 3 3 1 0.00230414746543779
TF TF:M00470_1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 0.0249444853473008 5600 114 50 0.43859649122807 0.00892857142857143
TF TF:M00477 Factor: FOXO3; motif: TNNTTGTTTACNTW 0.0254779868228191 2612 4 4 1 0.00153139356814701
TF TF:M00473 Factor: FOXO1; motif: NRWAAACAAN 0.0254779868228191 2604 4 4 1 0.00153609831029186
TF TF:M09862 Factor: ZNF614; motif: NCYCWGCCYYNNN 0.0263232665335617 9361 72 49 0.680555555555556 0.00523448349535306
TF TF:M04262 Factor: FOXO4; motif: GTAAACA 0.0263232665335617 1877 8 5 0.625 0.0026638252530634
TF TF:M04241 Factor: FOXD3; motif: GTAAAYA 0.0263232665335617 1877 8 5 0.625 0.0026638252530634
TF TF:M11743_1 Factor: COUP-TF1; motif: RAGGTCANYGACCTY; match class: 1 0.0263232665335617 4014 95 34 0.357894736842105 0.00847035376183358
TF TF:M01973_1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 0.0263232665335617 2398 84 22 0.261904761904762 0.00917431192660551
TF TF:M06178 Factor: ZNF81; motif: NGTTCATGTACA 0.0263232665335617 20 135 3 0.0222222222222222 0.15
TF TF:M00800 Factor: AP-2; motif: GSCCSCRGGCNRNRNN 0.0264044668350379 9119 138 84 0.608695652173913 0.00921153635267025
TF TF:M08957 Factor: NURR1:RXR-ALPHA; motif: NRGGTCRTTGACCYN 0.0264044668350379 8851 40 29 0.725 0.00327646593605242
TF TF:M00476 Factor: FOXO4; motif: NNGTTGTTTACNTN 0.0264044668350379 2740 4 4 1 0.00145985401459854
TF TF:M05439_1 Factor: RREB-1; motif: GGGWCSA; match class: 1 0.0264044668350379 3200 69 23 0.333333333333333 0.0071875
TF TF:M09665 Factor: RBPJK; motif: SYGTGRGAANN 0.0264044668350379 4441 61 26 0.426229508196721 0.00585453726638145
TF TF:M09784 Factor: RELB; motif: NNATTCCCCNN 0.0264044668350379 5356 29 17 0.586206896551724 0.00317401045556385
TF TF:M11743 Factor: COUP-TF1; motif: RAGGTCANYGACCTY 0.0264044668350379 4545 95 37 0.389473684210526 0.00814081408140814
TF TF:M09862_1 Factor: ZNF614; motif: NCYCWGCCYYNNN; match class: 1 0.0268192302725224 4193 61 25 0.409836065573771 0.00596231814929645
TF TF:M08952 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN 0.0268852164236037 7763 60 37 0.616666666666667 0.0047661986345485
TF TF:M07602 Factor: CP2; motif: NNNNCCAGNCNN 0.0275133388263741 11087 122 87 0.713114754098361 0.00784702805087039
TF TF:M10032 Factor: PREP-1; motif: TGANTGRCAGS 0.0275133388263741 1458 3 3 1 0.00205761316872428
TF TF:M11558 Factor: FKHL14; motif: NWNNGTMAACAN 0.0275133388263741 4151 5 5 1 0.0012045290291496
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.0275133388263741 3919 65 25 0.384615384615385 0.006379178361827
TF TF:M00432 Factor: TTF1; motif: ASTCAAGTRK 0.0275133388263741 5394 6 6 1 0.00111234705228031
TF TF:M11340_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.0276216244536638 525 85 9 0.105882352941176 0.0171428571428571
TF TF:M00104_1 Factor: CDP; motif: NATCGATCGS; match class: 1 0.0276216244536638 1353 28 8 0.285714285714286 0.00591278640059128
TF TF:M08891 Factor: NFKAPPAB; motif: NNGGGANTTCCCN 0.0276216244536638 2110 60 16 0.266666666666667 0.00758293838862559
TF TF:M00194 Factor: NF-kappaB; motif: NGGGGAMTTTCCNN 0.0279966599644931 2412 21 9 0.428571428571429 0.00373134328358209
TF TF:M12140 Factor: Egr-1; motif: NNCRCCCMCGCNN 0.0279966599644931 5360 66 31 0.46969696969697 0.00578358208955224
TF TF:M11546 Factor: foxo4; motif: NNGTMAACAN 0.0279966599644931 4235 5 5 1 0.00118063754427391
TF TF:M09739 Factor: ZGPAT; motif: GRGGCWGNGGNG 0.0279966599644931 8226 30 22 0.733333333333333 0.00267444687575979
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.028153736643659 8944 122 74 0.60655737704918 0.0082737030411449
TF TF:M11940 Factor: POU4F3; motif: TNATGCATNA 0.028153736643659 975 4 3 0.75 0.00307692307692308
TF TF:M08957_1 Factor: NURR1:RXR-ALPHA; motif: NRGGTCRTTGACCYN; match class: 1 0.0290867688333551 3226 87 27 0.310344827586207 0.00836949783013019
TF TF:M01721 Factor: PUR1; motif: GGGNCAGNN 0.0290867688333551 9145 76 50 0.657894736842105 0.00546746856205577
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.0290867688333551 8227 81 49 0.604938271604938 0.00595599854138811
TF TF:M07051 Factor: NF-1B; motif: CTGGCASGV 0.0291464711401837 3915 122 40 0.327868852459016 0.0102171136653895
TF TF:M09729_1 Factor: LUMAN; motif: CYCAGCYYCY; match class: 1 0.0291464711401837 4645 69 29 0.420289855072464 0.00624327233584499
TF TF:M11581 Factor: FOXI1; motif: NNNNNGTAAACAN 0.0291464711401837 1575 3 3 1 0.0019047619047619
TF TF:M00088_1 Factor: Ik-3; motif: TNYTGGGAATACC; match class: 1 0.0299057897574631 1019 4 3 0.75 0.00294406280667321
TF TF:M01857_1 Factor: AP-2alpha; motif: NGCCYSNNGSN; match class: 1 0.0302571337989794 4616 122 45 0.368852459016393 0.00974870017331022
TF TF:M09968 Factor: KLF15; motif: RGGGMGGRGNNGGGGGNGG 0.0302571337989794 3157 112 32 0.285714285714286 0.0101362052581565
TF TF:M03895_1 Factor: CTCF; motif: WGCGCCMYCTAGYGGYN; match class: 1 0.0302571337989794 3511 13 8 0.615384615384615 0.00227855311876958
TF TF:M01308_1 Factor: Sox-4; motif: AACAAWGR; match class: 1 0.0311392830440026 107 70 4 0.0571428571428571 0.0373831775700935
TF TF:M10637_1 Factor: Nkx2-3; motif: NSCACTTNNC; match class: 1 0.0314499884854598 106 71 4 0.0563380281690141 0.0377358490566038
TF TF:M01857 Factor: AP-2alpha; motif: NGCCYSNNGSN 0.0318130292793898 9178 120 74 0.616666666666667 0.00806275877097407
TF TF:M11589 Factor: FOXK1; motif: NNNGTAAACAN 0.0323627192916497 4486 5 5 1 0.00111457868925546
TF TF:M09734 Factor: ZNF692; motif: SYNGGSCCCASCCNC 0.032415833403443 11678 66 52 0.787878787878788 0.00445281726323001
TF TF:M12058 Factor: ZBP99; motif: GCCCCTCCCCCA 0.032415833403443 234 58 5 0.0862068965517241 0.0213675213675214
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.0326675757724422 5198 66 30 0.454545454545455 0.00577145055790689
TF TF:M04201_1 Factor: CEBPB; motif: ATTRCGCAAY; match class: 1 0.0334679172559953 1501 128 21 0.1640625 0.0139906728847435
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.0334679172559953 12302 139 105 0.755395683453237 0.0085351975288571
TF TF:M10528 Factor: SNA; motif: NNRGCAGGTGCNNNN 0.0334679172559953 4562 84 33 0.392857142857143 0.00723366944322665
TF TF:M01072_1 Factor: HIC1; motif: NSNNNNTGCCCSSNN; match class: 1 0.0334679172559953 893 77 11 0.142857142857143 0.0123180291153415
TF TF:M08330 Factor: GCMb:FIGLA; motif: ATGCGGGTNCASSTG 0.0334679172559953 376 56 6 0.107142857142857 0.0159574468085106
TF TF:M11498 Factor: OC-2; motif: NNATCGATYN 0.0354841083981535 1129 4 3 0.75 0.00265721877767936
TF TF:M04054_1 Factor: NF-kappaB; motif: AGGGGAWTCCCCT; match class: 1 0.0365904557709159 1295 81 14 0.172839506172839 0.0108108108108108
TF TF:M09784_1 Factor: RELB; motif: NNATTCCCCNN; match class: 1 0.0371819021238973 931 87 12 0.137931034482759 0.0128893662728249
TF TF:M11745 Factor: COUP-TF1; motif: RAGGTCANTGACCTY 0.0371819021238973 5058 51 24 0.470588235294118 0.00474495848161329
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.0371819021238973 7557 84 47 0.55952380952381 0.00621939923249967
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0373512161584096 5262 66 30 0.454545454545455 0.00570125427594071
TF TF:M04003_1 Factor: LEF-1; motif: AAAGATCAAAGGRWW; match class: 1 0.0384598994522954 130 28 3 0.107142857142857 0.0230769230769231
TF TF:M11550 Factor: FOXD2; motif: GYTRNGTMAACAN 0.0399962911079709 2280 8 5 0.625 0.00219298245614035
TF TF:M01783_1 Factor: SP2; motif: GGGCGGGAC; match class: 1 0.0400133697979322 4333 22 12 0.545454545454545 0.00276944380336949
TF TF:M00325_1 Factor: NRSE; motif: TTYAGCWCCDCGGASAGYRCC; match class: 1 0.0405403508496045 108 35 3 0.0857142857142857 0.0277777777777778
TF TF:M11365_1 Factor: MafA; motif: NYGCTGASTCAGCRN; match class: 1 0.0405403508496045 467 85 8 0.0941176470588235 0.0171306209850107
TF TF:M09618 Factor: HNF-3alpha; motif: NTRTTTACWYWNN 0.0405403508496045 2353 5 4 0.8 0.00169995750106247
TF TF:M10091 Factor: TCF-1; motif: NNNMACATCAAAGNNN 0.0405403508496045 2341 15 7 0.466666666666667 0.00299017513882956
TF TF:M09925 Factor: HNF-3alpha; motif: TGTTTACWYWNN 0.0405403508496045 2335 5 4 0.8 0.00171306209850107
TF TF:M01177_1 Factor: SREBP-2; motif: NNGYCACNNSMN; match class: 1 0.0405403508496045 2842 132 33 0.25 0.0116115411681914
TF TF:M00008_1 Factor: Sp1; motif: GGGGCGGGGT; match class: 1 0.0405403508496045 4937 130 49 0.376923076923077 0.00992505570184322
TF TF:M11490 Factor: LBP-1; motif: NRCCGGTNNNNACCGGYN 0.0405403508496045 6748 79 41 0.518987341772152 0.00607587433313574
TF TF:M07460 Factor: KLF3; motif: CCMCRCCCNG 0.042083142054189 1437 110 18 0.163636363636364 0.0125260960334029
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.042083142054189 6260 139 62 0.446043165467626 0.00990415335463259
TF TF:M11047 Factor: CLOCK; motif: NMCACGTGYN 0.0422327358752126 479 65 7 0.107692307692308 0.0146137787056367
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.0422327358752126 4320 66 26 0.393939393939394 0.00601851851851852
TF TF:M01239 Factor: RelB:p52; motif: GGGGNTTTCC 0.0444696891269538 796 134 14 0.104477611940299 0.0175879396984925
TF TF:M11541_1 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN; match class: 1 0.0444696891269538 5493 104 44 0.423076923076923 0.00801019479337338
TF TF:M08232_1 Factor: Elk-1:TEF; motif: RCCGGAAGTTACGTAAN; match class: 1 0.0450600391498199 1294 4 3 0.75 0.00231839258114374
TF TF:M09668 Factor: RelA-p65; motif: GGGRNTTTCCM 0.0450744973929466 3576 4 4 1 0.00111856823266219
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0452045952296241 6225 127 57 0.448818897637795 0.0091566265060241
TF TF:M01100_1 Factor: LRF; motif: GGGGKYNNB; match class: 1 0.0464239656781939 2762 33 12 0.363636363636364 0.00434467776973208
TF TF:M09764 Factor: ROX; motif: GNNNCASGTGGS 0.0466089283535253 5809 8 7 0.875 0.00120502668273369
TF TF:M04715 Factor: Oct-2; motif: ATTTGCA 0.0466089283535253 6381 6 6 1 0.000940291490362012
TF TF:M12232 Factor: c-Krox; motif: NCGACCACCN 0.0467268294954654 2982 84 24 0.285714285714286 0.00804828973843058
TF TF:M11739 Factor: COUP-TF1; motif: RRGGTCRNTGACCTN 0.0467268294954654 2698 87 23 0.264367816091954 0.00852483320978503
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.047314035961245 7283 66 37 0.560606060606061 0.00508032404229026
TF TF:M11526 Factor: E2F-3; motif: NTTTTGGCGCCAAAAN 0.0473926115254914 7178 12 10 0.833333333333333 0.00139314572304263
TF TF:M10056 Factor: DRRS; motif: GNNGGGWGGG 0.0473926115254914 4799 125 46 0.368 0.00958533027714107
TF TF:M06444 Factor: ZNF557; motif: NCCGCKTCCTGC 0.0473926115254914 1344 4 3 0.75 0.00223214285714286
TF TF:M11165 Factor: HAND2; motif: AACACCTGCN 0.0473926115254914 413 23 4 0.173913043478261 0.00968523002421308
TF TF:M11346_1 Factor: MafG; motif: NTGCTGASTCAGCAN; match class: 1 0.048140851469862 302 78 6 0.0769230769230769 0.0198675496688742
TF TF:M00208 Factor: NF-kappaB; motif: NGGGACTTTCCA 0.0491491383159941 3757 4 4 1 0.00106467926537131
TF TF:M04706 Factor: RelA; motif: GGGRAWTYC 0.0491491383159941 2278 25 9 0.36 0.00395083406496927
TF TF:M00744 Factor: POU1F1; motif: ATGAATAAWT 0.0491491383159941 2575 5 4 0.8 0.00155339805825243
TF TF:M06948_1 Factor: Sp2; motif: TGGGCGCGCCCA; match class: 1 0.0498943590262378 6205 139 61 0.438848920863309 0.00983078162771958
TF TF:M08487_1 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG; match class: 1 0.049896281902935 8790 137 79 0.576642335766423 0.00898748577929465
WP WP:WP4754 IL-18 signaling pathway 6.88324521199073e-08 279 44 14 0.318181818181818 0.0501792114695341
WP WP:WP5039 SARS-CoV-2 Innate Immunity Evasion and Cell-specific immune response 3.92631783480423e-06 68 5 4 0.8 0.0588235294117647
WP WP:WP262 EBV LMP1 signaling 1.81678576662852e-05 24 44 5 0.113636363636364 0.208333333333333
WP WP:WP3617 Photodynamic therapy-induced NF-kB survival signaling 0.000404144996720862 35 102 6 0.0588235294117647 0.171428571428571
WP WP:WP3624 Lung fibrosis 0.000952818258199692 63 44 5 0.113636363636364 0.0793650793650794
WP WP:WP710 DNA Damage Response (only ATM dependent) 0.000952818258199692 114 56 7 0.125 0.0614035087719298
WP WP:WP231 TNF alpha Signaling Pathway 0.000952818258199692 94 48 6 0.125 0.0638297872340425
WP WP:WP4304 Oligodendrocyte specification and differentiation, leading to Myelin Components for CNS 0.000952818258199692 31 44 4 0.0909090909090909 0.129032258064516
WP WP:WP2431 Spinal Cord Injury 0.00106622205958145 118 5 3 0.6 0.0254237288135593
WP WP:WP236 Adipogenesis 0.00237310909887713 131 44 6 0.136363636363636 0.0458015267175573
WP WP:WP2203 Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway 0.00253667307987979 47 16 3 0.1875 0.0638297872340425
WP WP:WP615 Senescence and Autophagy in Cancer 0.00253667307987979 108 35 5 0.142857142857143 0.0462962962962963
WP WP:WP2817 Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4) 0.00272595175557551 33 24 3 0.125 0.0909090909090909
WP WP:WP1449 Regulation of toll-like receptor signaling pathway 0.00391807643701692 145 46 6 0.130434782608696 0.0413793103448276
WP WP:WP2864 Apoptosis-related network due to altered Notch3 in ovarian cancer 0.00408550130902295 54 44 4 0.0909090909090909 0.0740740740740741
WP WP:WP3599 Transcription factor regulation in adipogenesis 0.00408550130902295 22 44 3 0.0681818181818182 0.136363636363636
WP WP:WP4329 miRNAs involvement in the immune response in sepsis 0.00518828775466021 63 74 5 0.0675675675675676 0.0793650793650794
WP WP:WP2882 Nuclear Receptors Meta-Pathway 0.00620695273701677 321 44 8 0.181818181818182 0.0249221183800623
WP WP:WP4493 Cells and Molecules involved in local acute inflammatory response 0.00734679391323285 17 74 3 0.0405405405405405 0.176470588235294
WP WP:WP176 Folate Metabolism 0.00804497634739129 73 74 5 0.0675675675675676 0.0684931506849315
WP WP:WP3851 TLR4 Signaling and Tolerance 0.00804497634739129 30 44 3 0.0681818181818182 0.1
WP WP:WP2877 Vitamin D Receptor Pathway 0.0114218311404281 182 20 4 0.2 0.021978021978022
WP WP:WP3929 Chemokine signaling pathway 0.0114218311404281 165 10 3 0.3 0.0181818181818182
WP WP:WP15 Selenium Micronutrient Network 0.012650586776361 91 102 6 0.0588235294117647 0.0659340659340659
WP WP:WP2112 IL17 signaling pathway 0.0130321968829863 32 54 3 0.0555555555555556 0.09375
WP WP:WP4659 Gastrin Signaling Pathway 0.0138486208152383 114 16 3 0.1875 0.0263157894736842
WP WP:WP1533 Vitamin B12 Metabolism 0.0142393711817039 53 74 4 0.0540540540540541 0.0754716981132075
WP WP:WP2036 TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway 0.0144696206083416 42 44 3 0.0681818181818182 0.0714285714285714
WP WP:WP3287 Overview of nanoparticle effects 0.0153865169247592 19 102 3 0.0294117647058824 0.157894736842105
WP WP:WP2880 Glucocorticoid Receptor Pathway 0.0191078404375345 71 102 5 0.0490196078431373 0.0704225352112676
WP WP:WP2637 Structural Pathway of Interleukin 1 (IL-1) 0.0224100133278895 50 46 3 0.0652173913043478 0.06
WP WP:WP75 Toll-like Receptor Signaling Pathway 0.0225535861892716 104 46 4 0.0869565217391304 0.0384615384615385
WP WP:WP395 IL-4 Signaling Pathway 0.0225535861892716 55 43 3 0.0697674418604651 0.0545454545454545
WP WP:WP254 Apoptosis 0.0225535861892716 86 56 4 0.0714285714285714 0.0465116279069767
WP WP:WP4963 p53 transcriptional gene network 0.0290193870699943 72 74 4 0.0540540540540541 0.0555555555555556
WP WP:WP619 Type II interferon signaling (IFNG) 0.0295844875346263 37 74 3 0.0405405405405405 0.0810810810810811
WP WP:WP2374 Oncostatin M Signaling Pathway 0.0298951463469602 66 43 3 0.0697674418604651 0.0454545454545455
WP WP:WP3863 T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection 0.0298951463469602 62 46 3 0.0652173913043478 0.0483870967741935
WP WP:WP4341 Non-genomic actions of 1,25 dihydroxyvitamin D3 0.035683924525717 70 44 3 0.0681818181818182 0.0428571428571429
WP WP:WP2037 Prolactin Signaling Pathway 0.0401528255324515 76 43 3 0.0697674418604651 0.0394736842105263
WP WP:WP3414 Initiation of transcription and translation elongation at the HIV-1 LTR 0.0448267309455485 37 94 3 0.0319148936170213 0.0810810810810811
WP WP:WP4336 ncRNAs involved in Wnt signaling in hepatocellular carcinoma 0.0464069595540368 89 40 3 0.075 0.0337078651685393

pEpiTd17 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd17
Possible regulators of activation of pEpiTd17 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.