pEpi24 program activity among Epithelial cells

Activation of pEpi24
pEpi24 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi24 by different cell subtypes
pEpi24 gene program activation among cells of different subtypes (Epithelial cells).

pEpi24 top program genes

Top genes of pEpi24 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi24 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi24
pEpi24 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0034599 cellular response to oxidative stress 0.0102216680248798 316 4 3 0.75 0.00949367088607595
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.0102216680248798 6563 53 35 0.660377358490566 0.00533292701508457
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 0.0102216680248798 446 72 9 0.125 0.0201793721973094
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.0102216680248798 5051 26 17 0.653846153846154 0.0033656701643239
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0102216680248798 5017 23 16 0.695652173913043 0.00318915686665338
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0102216680248798 1001 35 9 0.257142857142857 0.00899100899100899
GO:BP GO:0009059 macromolecule biosynthetic process 0.0102216680248798 5114 26 17 0.653846153846154 0.003324208056316
GO:BP GO:0016071 mRNA metabolic process 0.0102216680248798 874 48 10 0.208333333333333 0.011441647597254
GO:BP GO:0090150 establishment of protein localization to membrane 0.0102216680248798 351 46 7 0.152173913043478 0.0199430199430199
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0102216680248798 5746 34 22 0.647058823529412 0.00382875043508528
GO:BP GO:0062197 cellular response to chemical stress 0.0102216680248798 365 4 3 0.75 0.00821917808219178
GO:BP GO:0006979 response to oxidative stress 0.0102216680248798 466 4 3 0.75 0.00643776824034335
GO:BP GO:0006413 translational initiation 0.0102216680248798 201 38 5 0.131578947368421 0.0248756218905473
GO:BP GO:0032922 circadian regulation of gene expression 0.0126360424405933 67 26 3 0.115384615384615 0.0447761194029851
GO:BP GO:0046483 heterocycle metabolic process 0.0126360424405933 5904 34 22 0.647058823529412 0.00372628726287263
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0132939011668143 290 7 3 0.428571428571429 0.0103448275862069
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0132939011668143 5956 34 22 0.647058823529412 0.00369375419744795
GO:BP GO:0006396 RNA processing 0.0142996430361953 964 86 14 0.162790697674419 0.0145228215767635
GO:BP GO:0006605 protein targeting 0.0142996430361953 441 35 6 0.171428571428571 0.0136054421768707
GO:BP GO:0051204 protein insertion into mitochondrial membrane 0.0142996430361953 48 43 3 0.0697674418604651 0.0625
GO:BP GO:0090304 nucleic acid metabolic process 0.0142996430361953 5226 29 18 0.620689655172414 0.0034443168771527
GO:BP GO:0016070 RNA metabolic process 0.0163540163540285 4710 27 16 0.592592592592593 0.00339702760084926
GO:BP GO:0072594 establishment of protein localization to organelle 0.0163540163540285 584 52 8 0.153846153846154 0.0136986301369863
GO:BP GO:0090151 establishment of protein localization to mitochondrial membrane 0.0163540163540285 53 43 3 0.0697674418604651 0.0566037735849057
GO:BP GO:0044249 cellular biosynthetic process 0.0163540163540285 6154 24 17 0.708333333333333 0.00276243093922652
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0163540163540285 6201 34 22 0.647058823529412 0.00354781486856959
GO:BP GO:1901576 organic substance biosynthetic process 0.0171116008641263 6248 24 17 0.708333333333333 0.00272087067861716
GO:BP GO:0019222 regulation of metabolic process 0.0171116008641263 7148 40 27 0.675 0.00377728035814214
GO:BP GO:0016032 viral process 0.0184909297697039 942 35 8 0.228571428571429 0.00849256900212314
GO:BP GO:0009058 biosynthetic process 0.0191843194191312 6340 24 17 0.708333333333333 0.0026813880126183
GO:BP GO:0044238 primary metabolic process 0.019265190688084 10584 53 43 0.811320754716981 0.00406273620559335
GO:BP GO:0006886 intracellular protein transport 0.0218511418611663 1186 52 11 0.211538461538462 0.00927487352445194
GO:BP GO:1901575 organic substance catabolic process 0.0236950320950828 2267 43 14 0.325581395348837 0.00617556241729157
GO:BP GO:0010467 gene expression 0.0249767749389378 6179 27 18 0.666666666666667 0.00291309273345201
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.0251733953762488 4199 23 13 0.565217391304348 0.00309597523219814
GO:BP GO:0034470 ncRNA processing 0.0255990620035856 397 86 8 0.0930232558139535 0.0201511335012594
GO:BP GO:0018130 heterocycle biosynthetic process 0.0286272511855126 4269 23 13 0.565217391304348 0.00304520965097212
GO:BP GO:0019438 aromatic compound biosynthetic process 0.028667810684397 4278 23 13 0.565217391304348 0.00303880317905563
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0289745210219974 6603 40 25 0.625 0.0037861578070574
GO:BP GO:0097659 nucleic acid-templated transcription 0.0294036654325917 3715 23 12 0.521739130434783 0.00323014804845222
GO:BP GO:0006351 transcription, DNA-templated 0.0294036654325917 3714 23 12 0.521739130434783 0.00323101777059774
GO:BP GO:0032774 RNA biosynthetic process 0.0300607220951647 3731 23 12 0.521739130434783 0.00321629589922273
GO:BP GO:0044237 cellular metabolic process 0.0302782059713987 10871 53 43 0.811320754716981 0.00395547787692025
GO:BP GO:0051205 protein insertion into membrane 0.0302782059713987 78 43 3 0.0697674418604651 0.0384615384615385
GO:BP GO:0006807 nitrogen compound metabolic process 0.0302782059713987 10078 53 41 0.773584905660377 0.00406826751339551
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0336952773037853 4439 23 13 0.565217391304348 0.00292858751971165
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.0358013317354636 1628 31 9 0.290322580645161 0.00552825552825553
GO:BP GO:0033365 protein localization to organelle 0.0358013317354636 1017 79 12 0.151898734177215 0.0117994100294985
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.0358013317354636 1707 31 9 0.290322580645161 0.00527240773286467
GO:BP GO:0031323 regulation of cellular metabolic process 0.0358013317354636 6269 40 23 0.575 0.00366884670601372
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 0.0358013317354636 218 39 4 0.102564102564103 0.018348623853211
GO:BP GO:0022618 ribonucleoprotein complex assembly 0.0358013317354636 197 20 3 0.15 0.0152284263959391
GO:BP GO:0070887 cellular response to chemical stimulus 0.0358013317354636 3393 6 5 0.833333333333333 0.00147362216327734
GO:BP GO:0071407 cellular response to organic cyclic compound 0.0358013317354636 587 29 5 0.172413793103448 0.00851788756388416
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 0.0358013317354636 4091 23 12 0.521739130434783 0.00293326814959668
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 0.0358013317354636 204 20 3 0.15 0.0147058823529412
GO:BP GO:0016072 rRNA metabolic process 0.0358013317354636 234 72 5 0.0694444444444444 0.0213675213675214
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 0.0358013317354636 117 35 3 0.0857142857142857 0.0256410256410256
GO:BP GO:0034660 ncRNA metabolic process 0.0358013317354636 493 86 8 0.0930232558139535 0.0162271805273834
GO:BP GO:0042254 ribosome biogenesis 0.0358013317354636 307 72 6 0.0833333333333333 0.0195439739413681
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0358013317354636 1151 56 10 0.178571428571429 0.00868809730668984
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0358013317354636 5848 33 19 0.575757575757576 0.00324897400820793
GO:BP GO:0042221 response to chemical 0.0358013317354636 4781 7 6 0.857142857142857 0.00125496758000418
GO:BP GO:0043043 peptide biosynthetic process 0.0358013317354636 790 64 9 0.140625 0.0113924050632911
GO:BP GO:0043603 cellular amide metabolic process 0.0358013317354636 1241 64 12 0.1875 0.0096696212731668
GO:BP GO:0043604 amide biosynthetic process 0.0358013317354636 932 64 10 0.15625 0.0107296137339056
GO:BP GO:0044248 cellular catabolic process 0.0358013317354636 2347 43 13 0.302325581395349 0.00553898593949723
GO:BP GO:0044265 cellular macromolecule catabolic process 0.0358013317354636 1231 43 9 0.209302325581395 0.00731112916328188
GO:BP GO:0044270 cellular nitrogen compound catabolic process 0.0358013317354636 608 51 7 0.137254901960784 0.0115131578947368
GO:BP GO:0045047 protein targeting to ER 0.0358013317354636 113 35 3 0.0857142857142857 0.0265486725663717
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.0358013317354636 1337 26 7 0.269230769230769 0.00523560209424084
GO:BP GO:0046700 heterocycle catabolic process 0.0358013317354636 602 51 7 0.137254901960784 0.0116279069767442
GO:BP GO:0046907 intracellular transport 0.0358013317354636 1767 55 13 0.236363636363636 0.00735710243350311
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0358013317354636 2518 31 11 0.354838709677419 0.00436854646544877
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.0358013317354636 3241 34 14 0.411764705882353 0.00431965442764579
GO:BP GO:0072657 protein localization to membrane 0.0358013317354636 665 46 7 0.152173913043478 0.0105263157894737
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.0358013317354636 1639 31 9 0.290322580645161 0.00549115314215985
GO:BP GO:0006402 mRNA catabolic process 0.0358013317354636 384 39 5 0.128205128205128 0.0130208333333333
GO:BP GO:0006401 RNA catabolic process 0.0358013317354636 424 39 5 0.128205128205128 0.0117924528301887
GO:BP GO:0006364 rRNA processing 0.0358013317354636 224 72 5 0.0694444444444444 0.0223214285714286
GO:BP GO:2001141 regulation of RNA biosynthetic process 0.0358013317354636 3540 26 12 0.461538461538462 0.00338983050847458
GO:BP GO:0006355 regulation of transcription, DNA-templated 0.0358013317354636 3534 26 12 0.461538461538462 0.0033955857385399
GO:BP GO:0000398 mRNA splicing, via spliceosome 0.0358013317354636 361 68 6 0.0882352941176471 0.0166204986149584
GO:BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 0.0358013317354636 361 68 6 0.0882352941176471 0.0166204986149584
GO:BP GO:0000375 RNA splicing, via transesterification reactions 0.0358013317354636 364 68 6 0.0882352941176471 0.0164835164835165
GO:BP GO:0006412 translation 0.0358013317354636 764 53 8 0.150943396226415 0.0104712041884817
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.0358013317354636 1339 26 7 0.269230769230769 0.00522778192681105
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 0.0358013317354636 4102 23 12 0.521739130434783 0.00292540224280839
GO:BP GO:0010468 regulation of gene expression 0.0358013317354636 5196 26 15 0.576923076923077 0.00288683602771363
GO:BP GO:0009892 negative regulation of metabolic process 0.0358013317354636 3479 35 15 0.428571428571429 0.00431158378844496
GO:BP GO:0009890 negative regulation of biosynthetic process 0.0358013317354636 1740 31 9 0.290322580645161 0.00517241379310345
GO:BP GO:2000112 regulation of cellular macromolecule biosynthetic process 0.0358013317354636 4071 23 12 0.521739130434783 0.00294767870302137
GO:BP GO:0009057 macromolecule catabolic process 0.0358013317354636 1468 43 10 0.232558139534884 0.00681198910081744
GO:BP GO:0009056 catabolic process 0.0358013317354636 2744 43 15 0.348837209302326 0.005466472303207
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 0.0358013317354636 3535 26 12 0.461538461538462 0.00339462517680339
GO:BP GO:1901361 organic cyclic compound catabolic process 0.0358013317354636 651 51 7 0.137254901960784 0.010752688172043
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.0358013317354636 1341 26 7 0.269230769230769 0.0052199850857569
GO:BP GO:0006518 peptide metabolic process 0.0358013317354636 955 64 10 0.15625 0.0104712041884817
GO:BP GO:1901700 response to oxygen-containing compound 0.0358013317354636 1739 7 4 0.571428571428571 0.00230017251293847
GO:BP GO:0008152 metabolic process 0.0358013317354636 11827 53 45 0.849056603773585 0.00380485330176714
GO:BP GO:0071704 organic substance metabolic process 0.0376252906944556 11326 53 43 0.811320754716981 0.00379657425392901
GO:BP GO:0070972 protein localization to endoplasmic reticulum 0.0376252906944556 146 35 3 0.0857142857142857 0.0205479452054795
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0376252906944556 1227 5 3 0.6 0.00244498777506112
GO:BP GO:0031326 regulation of cellular biosynthetic process 0.0376252906944556 4273 23 12 0.521739130434783 0.00280833138310321
GO:BP GO:0007623 circadian rhythm 0.0379880561738329 219 49 4 0.0816326530612245 0.0182648401826484
GO:BP GO:0042493 response to drug 0.040465418934919 396 66 6 0.0909090909090909 0.0151515151515152
GO:BP GO:0009889 regulation of biosynthetic process 0.0410969412533529 4361 23 12 0.521739130434783 0.0027516624627379
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0425457361333493 1445 26 7 0.269230769230769 0.00484429065743945
GO:BP GO:0008033 tRNA processing 0.0439886878043807 132 86 4 0.0465116279069767 0.0303030303030303
GO:BP GO:0034613 cellular protein localization 0.044018794181165 2014 46 12 0.260869565217391 0.00595829195630586
GO:BP GO:0080090 regulation of primary metabolic process 0.0445092843555886 6053 33 19 0.575757575757576 0.00313893936890798
GO:BP GO:0051252 regulation of RNA metabolic process 0.0446559293319288 3822 26 12 0.461538461538462 0.00313971742543171
GO:BP GO:0070727 cellular macromolecule localization 0.0448073862080424 2024 46 12 0.260869565217391 0.00592885375494071
GO:BP GO:0019079 viral genome replication 0.0459886253092871 131 89 4 0.0449438202247191 0.0305343511450382
GO:BP GO:0043170 macromolecule metabolic process 0.0474482345625522 9796 35 27 0.771428571428571 0.0027562270314414
GO:CC GO:1990904 ribonucleoprotein complex 0.00176041690829697 688 50 10 0.2 0.0145348837209302
GO:CC GO:0005829 cytosol 0.00176041690829697 5303 84 43 0.511904761904762 0.00810861776353008
GO:CC GO:0005622 intracellular anatomical structure 0.00435445915698908 14790 86 81 0.941860465116279 0.00547667342799189
GO:CC GO:0032991 protein-containing complex 0.00435445915698908 5548 40 24 0.6 0.00432588320115357
GO:CC GO:0005681 spliceosomal complex 0.0081612172866134 191 48 5 0.104166666666667 0.0261780104712042
GO:CC GO:0071011 precatalytic spliceosome 0.0132636170365663 52 48 3 0.0625 0.0576923076923077
GO:CC GO:0005634 nucleus 0.0132636170365663 7592 45 30 0.666666666666667 0.00395152792413066
GO:CC GO:0071005 U2-type precatalytic spliceosome 0.0132636170365663 50 48 3 0.0625 0.06
GO:CC GO:0005844 polysome 0.0153901913216339 72 38 3 0.0789473684210526 0.0416666666666667
GO:CC GO:0097525 spliceosomal snRNP complex 0.0154158772469918 59 48 3 0.0625 0.0508474576271186
GO:CC GO:0030532 small nuclear ribonucleoprotein complex 0.0212625987372625 68 48 3 0.0625 0.0441176470588235
GO:CC GO:0120114 Sm-like protein family complex 0.0312807434148551 80 48 3 0.0625 0.0375
GO:CC GO:0043230 extracellular organelle 0.0337585095001953 2263 23 8 0.347826086956522 0.00353513035793195
GO:CC GO:0005777 peroxisome 0.0337585095001953 141 69 4 0.0579710144927536 0.0283687943262411
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0337585095001953 11296 80 60 0.75 0.00531161473087819
GO:CC GO:0005840 ribosome 0.0337585095001953 245 47 4 0.0851063829787234 0.0163265306122449
GO:CC GO:1902494 catalytic complex 0.0337585095001953 1441 21 6 0.285714285714286 0.00416377515614157
GO:CC GO:0042579 microbody 0.0337585095001953 141 69 4 0.0579710144927536 0.0283687943262411
GO:CC GO:0070062 extracellular exosome 0.0337585095001953 2176 23 8 0.347826086956522 0.00367647058823529
GO:CC GO:0043229 intracellular organelle 0.0337585095001953 12491 84 67 0.797619047619048 0.00536386198062605
GO:CC GO:0005684 U2-type spliceosomal complex 0.0337585095001953 93 48 3 0.0625 0.032258064516129
GO:CC GO:1903561 extracellular vesicle 0.0337585095001953 2261 23 8 0.347826086956522 0.00353825740822645
GO:CC GO:0031967 organelle envelope 0.0374224817593088 1237 79 12 0.151898734177215 0.00970088924818108
GO:CC GO:0043226 organelle 0.0374224817593088 14008 86 74 0.86046511627907 0.00528269560251285
GO:CC GO:0031975 envelope 0.0374224817593088 1237 79 12 0.151898734177215 0.00970088924818108
GO:CC GO:0005654 nucleoplasm 0.0374428303884078 4102 74 26 0.351351351351351 0.00633837152608484
GO:CC GO:0043227 membrane-bounded organelle 0.0374428303884078 12858 80 65 0.8125 0.00505521854098616
GO:CC GO:0005737 cytoplasm 0.0374428303884078 11911 85 65 0.764705882352941 0.0054571404583998
GO:CC GO:0031981 nuclear lumen 0.0380237197104918 4444 86 31 0.36046511627907 0.00697569756975698
GO:CC GO:0005813 centrosome 0.0380237197104918 619 83 8 0.0963855421686747 0.012924071082391
GO:CC GO:0140513 nuclear protein-containing complex 0.0441733995592354 1249 72 11 0.152777777777778 0.00880704563650921
GO:MF GO:0003723 RNA binding 0.02577706009717 1943 53 14 0.264150943396226 0.00720535254760679
GO:MF GO:0008135 translation factor activity, RNA binding 0.0278789176840054 99 38 3 0.0789473684210526 0.0303030303030303
GO:MF GO:0042826 histone deacetylase binding 0.0278789176840054 116 33 3 0.0909090909090909 0.0258620689655172
GO:MF GO:0046983 protein dimerization activity 0.0283363883825374 1069 77 12 0.155844155844156 0.0112254443405051
GO:MF GO:0008022 protein C-terminus binding 0.0283363883825374 202 80 5 0.0625 0.0247524752475248
GO:MF GO:0090079 translation regulator activity, nucleic acid binding 0.0306776675117133 123 38 3 0.0789473684210526 0.024390243902439
GO:MF GO:0043021 ribonucleoprotein complex binding 0.0346223571887527 137 38 3 0.0789473684210526 0.0218978102189781
GO:MF GO:0044877 protein-containing complex binding 0.0351654529877912 1287 38 8 0.210526315789474 0.00621600621600622
GO:MF GO:0045296 cadherin binding 0.0363638056748026 333 61 5 0.0819672131147541 0.015015015015015
GO:MF GO:0003676 nucleic acid binding 0.0363638056748026 4276 53 21 0.39622641509434 0.004911131898971
GO:MF GO:0017111 nucleoside-triphosphatase activity 0.0386337294828922 872 59 8 0.135593220338983 0.00917431192660551
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0474260136139518 930 59 8 0.135593220338983 0.00860215053763441
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.0474260136139518 930 59 8 0.135593220338983 0.00860215053763441
GO:MF GO:0016462 pyrophosphatase activity 0.0474260136139518 928 59 8 0.135593220338983 0.00862068965517241
HPA HPA:0470683 skin 2; epidermal cells[High] 0.00707817350523181 1346 29 13 0.448275862068966 0.00965824665676077
HPA HPA:0530712 spleen; cells in red pulp[≥Medium] 0.0293934723112919 3049 43 24 0.558139534883721 0.00787143325680551
HPA HPA:0620223 vagina; squamous epithelial cells[High] 0.0393608978136179 1091 29 10 0.344827586206897 0.00916590284142988
HPA HPA:0110222 cervix, uterine; squamous epithelial cells[≥Medium] 0.0393608978136179 3617 48 28 0.583333333333333 0.00774122200718828
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 0.00362239096327117 560 12 6 0.5 0.0107142857142857
REAC REAC:R-HSA-2262752 Cellular responses to stress 0.00362239096327117 546 12 6 0.5 0.010989010989011
REAC REAC:R-HSA-72649 Translation initiation complex formation 0.0436558301067272 59 34 3 0.0882352941176471 0.0508474576271186
REAC REAC:R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 0.0436558301067272 60 34 3 0.0882352941176471 0.05
REAC REAC:R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 0.0436558301067272 52 34 3 0.0882352941176471 0.0576923076923077
REAC REAC:R-HSA-72702 Ribosomal scanning and start codon recognition 0.0436558301067272 59 34 3 0.0882352941176471 0.0508474576271186
REAC REAC:R-HSA-166520 Signaling by NTRKs 0.0436558301067272 130 30 4 0.133333333333333 0.0307692307692308
TF TF:M11432_1 Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 2.25778044830752e-05 1525 50 18 0.36 0.0118032786885246
TF TF:M09901_1 Factor: nerf; motif: NNNCCGGAAGTGN; match class: 1 2.25778044830752e-05 1363 50 17 0.34 0.012472487160675
TF TF:M11392_1 Factor: Erg; motif: NACCGGAARYN; match class: 1 2.25778044830752e-05 3233 93 38 0.408602150537634 0.0117537890504176
TF TF:M08913_1 Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 2.25778044830752e-05 3055 88 36 0.409090909090909 0.0117839607201309
TF TF:M09935_1 Factor: GABP-alpha; motif: NNNRCCGGAAGTGN; match class: 1 2.25778044830752e-05 1047 54 16 0.296296296296296 0.0152817574021012
TF TF:M01078_1 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN; match class: 1 2.47429324194585e-05 2448 50 22 0.44 0.00898692810457516
TF TF:M11447_1 Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 2.47429324194585e-05 2593 55 24 0.436363636363636 0.00925568839182414
TF TF:M01752_1 Factor: ERG; motif: ACCGGAART; match class: 1 2.56733889604351e-05 3705 88 39 0.443181818181818 0.0105263157894737
TF TF:M11396_1 Factor: Erg; motif: NACCGGAARTN; match class: 1 3.02166226038518e-05 4963 55 33 0.6 0.00664920411041709
TF TF:M02053_1 Factor: ELF1; motif: NCCGGAARTN; match class: 1 3.02276861621364e-05 1559 70 21 0.3 0.013470173187941
TF TF:M02059_1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 3.02276861621364e-05 3759 72 34 0.472222222222222 0.00904495876562916
TF TF:M11425_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 3.02276861621364e-05 2330 85 29 0.341176470588235 0.0124463519313305
TF TF:M00025_1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 3.14057059303525e-05 4639 72 38 0.527777777777778 0.00819142056477689
TF TF:M04714_1 Factor: Elf-1; motif: ACTTCCGGG; match class: 1 3.14057059303525e-05 2659 85 31 0.364705882352941 0.0116585182399398
TF TF:M02067_1 Factor: ER71; motif: ACCGGAARYN; match class: 1 3.14057059303525e-05 1619 93 25 0.268817204301075 0.0154416306361952
TF TF:M11451_1 Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 3.28013596109696e-05 2112 55 21 0.381818181818182 0.00994318181818182
TF TF:M01258_1 Factor: GABP; motif: CACTTCCGGNNN; match class: 1 3.30703635845168e-05 428 50 10 0.2 0.0233644859813084
TF TF:M02074 Factor: GABPalpha; motif: RCCGGAWRYN 3.30703635845168e-05 4607 73 38 0.520547945205479 0.00824831777729542
TF TF:M09905 Factor: SAP-1; motif: NNCCGGAAGTGN 3.34366133466645e-05 8273 73 53 0.726027397260274 0.00640638220717998
TF TF:M02063_1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 3.34455198327017e-05 2396 85 29 0.341176470588235 0.0121035058430718
TF TF:M02066_1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 4.38909383143392e-05 2283 85 28 0.329411764705882 0.0122645641699518
TF TF:M03988_1 Factor: FLI1; motif: ACCGGAARTN; match class: 1 4.71627408616355e-05 2950 88 33 0.375 0.0111864406779661
TF TF:M11452_1 Factor: Elf-1; motif: NANGCGGAAGTR; match class: 1 4.86995114276019e-05 1696 58 19 0.327586206896552 0.0112028301886792
TF TF:M11433_1 Factor: Elk-1; motif: NRCCGGAAGTN; match class: 1 5.49746237878594e-05 2261 50 20 0.4 0.00884564352056612
TF TF:M11450_1 Factor: Elf-1; motif: NANSCGGAAGTR; match class: 1 6.31263613899014e-05 1315 54 16 0.296296296296296 0.0121673003802281
TF TF:M11404_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 6.59362641778223e-05 3171 88 34 0.386363636363636 0.010722169662567
TF TF:M09900_1 Factor: Elf-1; motif: NNANCCGGAAGTGS; match class: 1 6.87293321325233e-05 1158 54 15 0.277777777777778 0.0129533678756477
TF TF:M02073_1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 7.06147942070608e-05 1488 55 17 0.309090909090909 0.0114247311827957
TF TF:M02055_1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 8.36330365738674e-05 2176 58 21 0.362068965517241 0.00965073529411765
TF TF:M01214_1 Factor: ESE-1; motif: NSMGGAARTN; match class: 1 8.36330365738674e-05 2176 58 21 0.362068965517241 0.00965073529411765
TF TF:M03990_1 Factor: GABPA; motif: ACCGGAAGTN; match class: 1 8.41227879439685e-05 1206 83 19 0.228915662650602 0.0157545605306799
TF TF:M03988 Factor: FLI1; motif: ACCGGAARTN 8.41227879439685e-05 8318 73 52 0.712328767123288 0.00625150276508776
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 8.41227879439685e-05 5051 71 38 0.535211267605634 0.00752326272025342
TF TF:M11382_1 Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 8.41227879439685e-05 4112 54 28 0.518518518518518 0.00680933852140078
TF TF:M11428_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 8.60501481236573e-05 2146 50 19 0.38 0.00885368126747437
TF TF:M00025 Factor: Elk-1; motif: NNNNCCGGAARTNN 9.52257795961534e-05 10262 56 47 0.839285714285714 0.00458000389787566
TF TF:M11392 Factor: Erg; motif: NACCGGAARYN 0.000109233977019918 8690 73 53 0.726027397260274 0.00609896432681243
TF TF:M03982_1 Factor: ETV4; motif: ACCGGAAGTN; match class: 1 0.000109233977019918 2009 85 25 0.294117647058824 0.0124440019910403
TF TF:M11400_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.000109233977019918 4201 93 41 0.440860215053763 0.00975958105213045
TF TF:M09905_1 Factor: SAP-1; motif: NNCCGGAAGTGN; match class: 1 0.000120216487258912 2989 88 32 0.363636363636364 0.0107059217129475
TF TF:M11430_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.000127211385783096 4902 85 42 0.494117647058824 0.00856793145654835
TF TF:M09606_1 Factor: nerf; motif: NRRNSCGGAAGNRNNNN; match class: 1 0.000142453253175601 1704 47 16 0.340425531914894 0.00938967136150235
TF TF:M02056 Factor: ELF4; motif: NCCGGAARTN 0.000142453253175601 5332 67 37 0.552238805970149 0.00693923480870218
TF TF:M03975_1 Factor: ERG; motif: ACCGGAARTN; match class: 1 0.000143250891021671 4024 72 33 0.458333333333333 0.00820079522862823
TF TF:M09904_1 Factor: Elk-1; motif: RCCGGAAGTGN; match class: 1 0.000145348707145138 2743 50 21 0.42 0.00765585125774699
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.000145685535517922 8322 55 41 0.745454545454545 0.0049267003124249
TF TF:M11424_1 Factor: Erm; motif: NNSCGGAWGYN; match class: 1 0.000146278948226156 2835 85 30 0.352941176470588 0.0105820105820106
TF TF:M02071_1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 0.000146278948226156 4465 72 35 0.486111111111111 0.00783874580067189
TF TF:M11427_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.00016871460440285 4606 85 40 0.470588235294118 0.00868432479374729
TF TF:M02062_1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 0.00016871460440285 2718 55 22 0.4 0.00809418690213392
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.000170930444629063 10116 65 52 0.8 0.00514037168841439
TF TF:M04698_1 Factor: GABP-alpha; motif: CACTTCCGG; match class: 1 0.000170930444629063 576 50 10 0.2 0.0173611111111111
TF TF:M11419_1 Factor: ER81; motif: NNCCGGAWGYN; match class: 1 0.000170930444629063 1427 50 15 0.3 0.0105115627189909
TF TF:M03977_1 Factor: ETS1; motif: ACCGGAARYN; match class: 1 0.000170930444629063 4677 90 42 0.466666666666667 0.00898011545862733
TF TF:M09605_1 Factor: Elf-1; motif: NAANCMGGAAGTGN; match class: 1 0.000170930444629063 1306 83 19 0.228915662650602 0.0145482388973966
TF TF:M02053 Factor: ELF1; motif: NCCGGAARTN 0.000173738749946877 6033 73 42 0.575342465753425 0.0069617105917454
TF TF:M02064_1 Factor: c-ets-2; motif: ACCGGAWRTN; match class: 1 0.000217348596745823 4592 55 29 0.527272727272727 0.00631533101045296
TF TF:M08418_1 Factor: TEF-3:Elk-1; motif: RMATWCCGGAWGT; match class: 1 0.000217348596745823 5247 72 38 0.527777777777778 0.007242233657328
TF TF:M02052_1 Factor: EHF; motif: CSCGGAARTN; match class: 1 0.000227104116735851 4056 58 28 0.482758620689655 0.00690335305719921
TF TF:M03970_1 Factor: ELK1; motif: ACCGGAAGTN; match class: 1 0.000236023927463465 1097 50 13 0.26 0.0118505013673655
TF TF:M00032_1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 1 0.00027226156650622 2161 50 18 0.36 0.00832947709393799
TF TF:M11449_1 Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 0.00027226156650622 695 55 11 0.2 0.0158273381294964
TF TF:M11434_1 Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 0.000306447939427998 2935 86 30 0.348837209302326 0.010221465076661
TF TF:M02054_1 Factor: ELF2; motif: CCCGGAARYN; match class: 1 0.000407163409708336 456 55 9 0.163636363636364 0.0197368421052632
TF TF:M09901 Factor: nerf; motif: NNNCCGGAAGTGN 0.000424739672367508 5352 55 31 0.563636363636364 0.00579222720478326
TF TF:M08423 Factor: TEF-3:ER81; motif: ACCGGAAATRCC 0.000445744869107299 3845 93 37 0.397849462365591 0.00962288686605982
TF TF:M02069_1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 0.000512436690900631 1955 85 23 0.270588235294118 0.0117647058823529
TF TF:M02074_1 Factor: GABPalpha; motif: RCCGGAWRYN; match class: 1 0.000512436690900631 1005 50 12 0.24 0.0119402985074627
TF TF:M09913_1 Factor: ER81; motif: NNCCGGAAGYG; match class: 1 0.0005256189856963 420 47 8 0.170212765957447 0.019047619047619
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.000551797131211677 4841 55 29 0.527272727272727 0.00599049783102665
TF TF:M11435_1 Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 0.000560263754808939 5745 55 32 0.581818181818182 0.00557006092254134
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.000656496472420274 6749 55 35 0.636363636363636 0.00518595347458883
TF TF:M03970 Factor: ELK1; motif: ACCGGAAGTN 0.000656496472420274 4782 90 41 0.455555555555556 0.00857381848598913
TF TF:M08451 Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA 0.000671281977378683 8421 86 57 0.662790697674419 0.00676879230495191
TF TF:M03791 Factor: GABPalpha_GABPbeta; motif: CTTCCKGY 0.000671281977378683 2969 93 31 0.333333333333333 0.0104412260020209
TF TF:M11451 Factor: Elf-1; motif: NANCCGGAAGTN 0.000671281977378683 6886 73 44 0.602739726027397 0.00638977635782748
TF TF:M02069 Factor: Erm; motif: ACCGGAAGTN 0.000675291478607688 6892 73 44 0.602739726027397 0.00638421358096344
TF TF:M08377 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN 0.00068933817854347 11275 94 74 0.787234042553192 0.00656319290465632
TF TF:M02067 Factor: ER71; motif: ACCGGAARYN 0.00068933817854347 5930 73 40 0.547945205479452 0.00674536256323777
TF TF:M11404 Factor: Fli-1; motif: NACCGGAARTN 0.00068933817854347 8743 73 51 0.698630136986301 0.00583323801898662
TF TF:M03971 Factor: ELK1; motif: NACTTCCGSCGGAAGYN 0.000757366140371587 11293 35 32 0.914285714285714 0.00283361374302665
TF TF:M11400 Factor: Fli-1; motif: NACCGGAARTN 0.000761800689758868 9946 65 50 0.769230769230769 0.00502714659159461
TF TF:M08759_1 Factor: c-Ets-2; motif: NCCGGAAGTG; match class: 1 0.000894524436841381 2915 50 20 0.4 0.00686106346483705
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.000976739014355411 5133 54 29 0.537037037037037 0.00564971751412429
TF TF:M01258 Factor: GABP; motif: CACTTCCGGNNN 0.00098155787738757 2838 90 29 0.322222222222222 0.0102184637068358
TF TF:M02059 Factor: ELK-1; motif: ACCGGAAGTN 0.00098155787738757 9423 55 42 0.763636363636364 0.00445717924227953
TF TF:M03967_1 Factor: ELF3; motif: WACCCGGAAGTAN; match class: 1 0.00108019009883095 1972 55 17 0.309090909090909 0.00862068965517241
TF TF:M11396 Factor: Erg; motif: NACCGGAARTN 0.00110277035873013 10765 65 52 0.8 0.00483046911286577
TF TF:M07415_1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 1 0.00110277035873013 2397 85 25 0.294117647058824 0.0104297037964122
TF TF:M01752 Factor: ERG; motif: ACCGGAART 0.00110277035873013 9474 55 42 0.763636363636364 0.00443318556048132
TF TF:M02066 Factor: PEA3; motif: RCCGGAAGYN 0.00110277035873013 7045 73 44 0.602739726027397 0.00624556422995032
TF TF:M11422_1 Factor: Erm; motif: NRCMGGAAGTN; match class: 1 0.00113506472234355 934 50 11 0.22 0.0117773019271949
TF TF:M02073 Factor: Fli-1; motif: ACCGGAAGYN 0.00113690219441613 5839 93 47 0.505376344086022 0.00804932351430039
TF TF:M11437_1 Factor: SAP-1; motif: NRCCGGAWGYN; match class: 1 0.00113690219441613 456 50 8 0.16 0.0175438596491228
TF TF:M03981_1 Factor: ETV3; motif: ACCGGAAGTN; match class: 1 0.00114354741302041 329 50 7 0.14 0.0212765957446809
TF TF:M03966_1 Factor: ELF1; motif: AACCCGGAAGTR; match class: 1 0.00114354741302041 1577 55 15 0.272727272727273 0.00951173113506658
TF TF:M03982 Factor: ETV4; motif: ACCGGAAGTN 0.00115609966571882 6826 73 43 0.589041095890411 0.00629944330501025
TF TF:M11448_1 Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 0.00127242162512294 2324 58 19 0.327586206896552 0.00817555938037866
TF TF:M11442_1 Factor: Net; motif: NACCGGAAGTN; match class: 1 0.00136653203260623 227 50 6 0.12 0.026431718061674
TF TF:M03977 Factor: ETS1; motif: ACCGGAARYN 0.00136798529565051 10512 65 51 0.784615384615385 0.00485159817351598
TF TF:M09773_1 Factor: HIF1A; motif: NNACGTGCNN; match class: 1 0.00139272470309095 683 95 13 0.136842105263158 0.0190336749633968
TF TF:M03969_1 Factor: ELF5; motif: ANSMGGAAGTN; match class: 1 0.00149868898075385 443 54 8 0.148148148148148 0.018058690744921
TF TF:M09607_1 Factor: SAP-1; motif: ACCGGAAGTNN; match class: 1 0.00152399148303926 977 50 11 0.22 0.0112589559877175
TF TF:M11425 Factor: PEA3; motif: NACCGGAAGTN 0.00155514206027764 7428 73 45 0.616438356164384 0.00605815831987076
TF TF:M11439 Factor: Net; motif: NRCCGGAAGTN 0.00155514206027764 2568 54 19 0.351851851851852 0.007398753894081
TF TF:M11428 Factor: PEA3; motif: NACCGGAAGTN 0.00161971304926968 7186 73 44 0.602739726027397 0.00612301697745616
TF TF:M09904 Factor: Elk-1; motif: RCCGGAAGTGN 0.00167204470885941 8164 55 38 0.690909090909091 0.00465458108770211
TF TF:M09900 Factor: Elf-1; motif: NNANCCGGAAGTGS 0.00168034577328874 5219 55 29 0.527272727272727 0.00555662004215367
TF TF:M02061 Factor: ERF; motif: ACCGGAARYN 0.00180354271154157 2579 50 18 0.36 0.00697944939899186
TF TF:M08423_1 Factor: TEF-3:ER81; motif: ACCGGAAATRCC; match class: 1 0.00185034385010872 654 50 9 0.18 0.0137614678899083
TF TF:M08345 Factor: HOXB2:PEA3; motif: ACCGGAAATGRN 0.0019692576531043 8027 73 47 0.643835616438356 0.00585523856982683
TF TF:M08759 Factor: c-Ets-2; motif: NCCGGAAGTG 0.00214510862679792 8319 73 48 0.657534246575342 0.00576992426974396
TF TF:M09606 Factor: nerf; motif: NRRNSCGGAAGNRNNNN 0.00233621027255602 6249 55 32 0.581818181818182 0.00512081933109297
TF TF:M11413_1 Factor: ER71; motif: NACCGGAARTN; match class: 1 0.00259489444298533 261 50 6 0.12 0.0229885057471264
TF TF:M11656 Factor: HSF1; motif: RGAANRTTCYRGAAN 0.00261653805759509 2033 75 20 0.266666666666667 0.00983767830791933
TF TF:M01109 Factor: SZF1-1; motif: CCAGGGTAWCAGCNG 0.00261653805759509 4253 70 30 0.428571428571429 0.00705384434516812
TF TF:M02062 Factor: Erg; motif: ACCGGAAGTN 0.00269635312019483 8056 93 57 0.612903225806452 0.00707547169811321
TF TF:M08917_1 Factor: GABP-ALPHA; motif: RCCGGAARTNN; match class: 1 0.00269635312019483 389 50 7 0.14 0.0179948586118252
TF TF:M11415 Factor: GABP-alpha; motif: NRCCGGAAGTN 0.00269635312019483 3257 93 31 0.333333333333333 0.00951796131409272
TF TF:M03983_1 Factor: ETV5; motif: NCCGGAWGYN; match class: 1 0.00280409962326332 537 50 8 0.16 0.0148975791433892
TF TF:M11432 Factor: Elk-1; motif: NACMGGAAGTN 0.0029847389096086 6140 90 46 0.511111111111111 0.00749185667752443
TF TF:M08760 Factor: ETV7; motif: NNSCGGAAGTR 0.00303396735351016 2349 93 25 0.268817204301075 0.0106428267347808
TF TF:M02054 Factor: ELF2; motif: CCCGGAARYN 0.00303396735351016 3066 73 25 0.342465753424658 0.00815394651011089
TF TF:M03983 Factor: ETV5; motif: NCCGGAWGYN 0.00333472692120315 3129 52 20 0.384615384615385 0.00639181847235539
TF TF:M02056_1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 0.00333472692120315 1291 50 12 0.24 0.00929512006196747
TF TF:M03975 Factor: ERG; motif: ACCGGAARTN 0.00339722355300668 10002 47 37 0.787234042553192 0.00369926014797041
TF TF:M11422 Factor: Erm; motif: NRCMGGAAGTN 0.00350585447133808 4669 54 26 0.481481481481481 0.00556864424930392
TF TF:M11414 Factor: GABP-alpha; motif: NACCGGAAGTN 0.00356966411593382 2907 73 24 0.328767123287671 0.00825593395252838
TF TF:M09605 Factor: Elf-1; motif: NAANCMGGAAGTGN 0.00359458565991063 5778 55 30 0.545454545454545 0.00519210799584631
TF TF:M11420 Factor: ER81; motif: NACCGGAAGTN 0.00359458565991063 3210 75 26 0.346666666666667 0.00809968847352025
TF TF:M11449 Factor: Elf-1; motif: NANCCGGAAGTN 0.00370279817687583 4305 55 25 0.454545454545455 0.00580720092915215
TF TF:M11437 Factor: SAP-1; motif: NRCCGGAWGYN 0.00390825032110584 2788 54 19 0.351851851851852 0.00681492109038737
TF TF:M09935 Factor: GABP-alpha; motif: NNNRCCGGAAGTGN 0.00396178659445835 4420 54 25 0.462962962962963 0.00565610859728507
TF TF:M04714 Factor: Elf-1; motif: ACTTCCGGG 0.0039826107972304 7798 55 36 0.654545454545455 0.00461656835085919
TF TF:M10849 Factor: Cdx-2; motif: NRTCGTAANNNN 0.0044976169609424 11163 73 57 0.780821917808219 0.00510615425960763
TF TF:M02057_1 Factor: Elf5; motif: CSMGGAARNN; match class: 1 0.00450541582756474 3538 66 25 0.378787878787879 0.00706613906161673
TF TF:M11430 Factor: PEA3; motif: NACCGGAAGTN 0.00452181330544124 10865 73 56 0.767123287671233 0.00515416474919466
TF TF:M11421_1 Factor: ER81; motif: NACCGGAAGTN; match class: 1 0.0045455728848739 299 50 6 0.12 0.020066889632107
TF TF:M03972 Factor: ELK3; motif: ACCGGAAGTN 0.00459259255238905 1211 90 16 0.177777777777778 0.0132122213047069
TF TF:M03971_1 Factor: ELK1; motif: NACTTCCGSCGGAAGYN; match class: 1 0.00463703185781027 7157 9 9 1 0.00125751012994271
TF TF:M02012 Factor: HIF-1alpha; motif: NCACGT 0.00463703185781027 6648 95 50 0.526315789473684 0.00752105896510229
TF TF:M11427 Factor: PEA3; motif: NACCGGAAGTN 0.00465619815357361 10585 73 55 0.753424657534247 0.00519603212092584
TF TF:M08760_1 Factor: ETV7; motif: NNSCGGAAGTR; match class: 1 0.00491687338019195 326 47 6 0.127659574468085 0.0184049079754601
TF TF:M11452 Factor: Elf-1; motif: NANGCGGAAGTR 0.00491687338019195 6276 50 29 0.58 0.00462077756532823
TF TF:M11450 Factor: Elf-1; motif: NANSCGGAAGTR 0.00510100518575768 5601 55 29 0.527272727272727 0.005177646848777
TF TF:M03981 Factor: ETV3; motif: ACCGGAAGTN 0.00526899784808118 2327 50 16 0.32 0.00687580575848732
TF TF:M11053_1 Factor: Hey2; motif: NGCACGTGYN; match class: 1 0.00555341072977263 558 41 7 0.170731707317073 0.0125448028673835
TF TF:M02068_1 Factor: etv3; motif: ACCGGAAGYN; match class: 1 0.00571312777678373 613 50 8 0.16 0.0130505709624796
TF TF:M10018 Factor: NRF-1; motif: CNSTGCGCATGCGCNNS 0.00581405074423431 1816 76 18 0.236842105263158 0.00991189427312775
TF TF:M07209 Factor: ELK4; motif: NCRCTTCCGGN 0.00608383870135307 1118 90 15 0.166666666666667 0.0134168157423971
TF TF:M11413 Factor: ER71; motif: NACCGGAARTN 0.00617909565902723 2111 50 15 0.3 0.00710563713879678
TF TF:M02072_1 Factor: Pet-1; motif: ACCGGAWRTN; match class: 1 0.00629177863304105 323 50 6 0.12 0.0185758513931889
TF TF:M07100 Factor: HSF1; motif: NTTCTRGAANNTTCY 0.00630100934665553 3350 75 26 0.346666666666667 0.00776119402985075
TF TF:M08451_1 Factor: Elk-1:HOXA1; motif: ACCGGAAGTAATTA; match class: 1 0.00651691490224007 2584 85 24 0.282352941176471 0.00928792569659443
TF TF:M09611 Factor: ER81; motif: NNNGRCMGGAAGYRNNNNNNNS 0.00667312108179586 2666 73 22 0.301369863013699 0.00825206301575394
TF TF:M02102 Factor: NRF-1; motif: YGCGCMTGCGC 0.00692505552394009 2020 76 19 0.25 0.00940594059405941
TF TF:M11447 Factor: Elf-1; motif: NAMCCGGAAGTN 0.00736760732723477 7703 55 35 0.636363636363636 0.0045436842788524
TF TF:M11059_1 Factor: Hey1; motif: NGCACGTGYN; match class: 1 0.00775485164651791 596 41 7 0.170731707317073 0.011744966442953
TF TF:M08917 Factor: GABP-ALPHA; motif: RCCGGAARTNN 0.00791494170732538 2702 73 22 0.301369863013699 0.00814211695040711
TF TF:M02065 Factor: ER81; motif: RCCGGAARYN 0.00830218390624627 12550 56 48 0.857142857142857 0.00382470119521912
TF TF:M04698 Factor: GABP-alpha; motif: CACTTCCGG 0.00899761168820831 3196 93 29 0.311827956989247 0.0090738423028786
TF TF:M11406 Factor: Pet-1; motif: NACCGGAAGTN 0.00899761168820831 1301 90 16 0.177777777777778 0.0122982321291314
TF TF:M02068 Factor: etv3; motif: ACCGGAAGYN 0.00984046294166979 3443 52 20 0.384615384615385 0.00580888759802498
TF TF:M01078 Factor: c-Ets-1; motif: NNNRCCGGAWRYNNNN 0.00995396945674933 7544 73 43 0.589041095890411 0.00569989395546129
TF TF:M03987 Factor: FEV; motif: ACCGGAAGTN 0.0102046705384285 1318 90 16 0.177777777777778 0.0121396054628225
TF TF:M08313_1 Factor: GCMa:PEA3; motif: ATRCGGGCGGAAGTR; match class: 1 0.0104816879958732 9721 68 48 0.705882352941177 0.00493776360456743
TF TF:M03990 Factor: GABPA; motif: ACCGGAAGTN 0.0104816879958732 5258 77 35 0.454545454545455 0.00665652339292507
TF TF:M09608_1 Factor: Erg; motif: NNACCGGAARTSN; match class: 1 0.0104816879958732 2389 52 16 0.307692307692308 0.00669736291335287
TF TF:M02063 Factor: c-ets-1; motif: ACCGGAWGTN 0.0109649649011749 7600 77 45 0.584415584415584 0.00592105263157895
TF TF:M11434 Factor: Elk-1; motif: NRSCGGAAGNN 0.0110459477698881 8219 55 36 0.654545454545455 0.00438009490205621
TF TF:M11059 Factor: Hey1; motif: NGCACGTGYN 0.0118939428771975 1813 95 20 0.210526315789474 0.0110314396028682
TF TF:M09913 Factor: ER81; motif: NNCCGGAAGYG 0.0118939428771975 2871 90 26 0.288888888888889 0.00905607802159526
TF TF:M11056_1 Factor: Hey1; motif: NGCACGYGYN; match class: 1 0.0119090656763918 663 95 11 0.115789473684211 0.0165912518853695
TF TF:M11401_1 Factor: Fli-1; motif: NACCGGATATCCGGTN; match class: 1 0.0119722978028967 11801 79 62 0.784810126582278 0.00525379205152106
TF TF:M00646_1 Factor: LF-A1; motif: GGGSTCWR; match class: 1 0.0120636371779626 6320 71 37 0.52112676056338 0.00585443037974684
TF TF:M01165_1 Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 0.0125274374592779 2185 52 15 0.288461538461538 0.0068649885583524
TF TF:M09607 Factor: SAP-1; motif: ACCGGAAGTNN 0.0132388501905423 4727 61 27 0.442622950819672 0.00571186799238418
TF TF:M11439_1 Factor: Net; motif: NRCCGGAAGTN; match class: 1 0.0132388501905423 382 50 6 0.12 0.0157068062827225
TF TF:M03969 Factor: ELF5; motif: ANSMGGAAGTN 0.0140164371147499 3339 55 20 0.363636363636364 0.00598981731057203
TF TF:M11415_1 Factor: GABP-alpha; motif: NRCCGGAAGTN; match class: 1 0.0142245806909942 546 50 7 0.14 0.0128205128205128
TF TF:M03976 Factor: ERG; motif: ACCGGAWATCCGGT 0.0146487574805774 12803 72 60 0.833333333333333 0.00468640162461923
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.0151708686712436 14873 95 85 0.894736842105263 0.00571505412492436
TF TF:M11772 Factor: NURR1; motif: NAAAGGTCAN 0.0155768262916638 4345 11 8 0.727272727272727 0.00184119677790564
TF TF:M01145 Factor: c-Myc; motif: RACCACGTGCTC 0.0155768262916638 6248 95 46 0.484210526315789 0.00736235595390525
TF TF:M07415 Factor: Elf-1; motif: AWCCCGGAAGTN 0.0156588524645194 7978 73 44 0.602739726027397 0.00551516670844823
TF TF:M11421 Factor: ER81; motif: NACCGGAAGTN 0.0156588524645194 2341 50 15 0.3 0.00640751815463477
TF TF:M11419 Factor: ER81; motif: NNCCGGAWGYN 0.0160541615198937 5699 95 43 0.452631578947368 0.00754518336550272
TF TF:M08953 Factor: FXR; motif: NAGGTCAWNKN 0.0168456404168236 4828 79 33 0.417721518987342 0.00683512841756421
TF TF:M11218 Factor: CREB1; motif: NRTGAYGCGTN 0.016992107995609 8461 18 15 0.833333333333333 0.0017728400898239
TF TF:M11401 Factor: Fli-1; motif: NACCGGATATCCGGTN 0.017761971558707 11952 79 62 0.784810126582278 0.00518741633199465
TF TF:M11356 Factor: c-MAF; motif: NYGCTGACN 0.0186598280035239 693 12 4 0.333333333333333 0.00577200577200577
TF TF:M10106_1 Factor: VDR; motif: NRGGTCANNGRGKTCA; match class: 1 0.0187921949394652 1628 6 4 0.666666666666667 0.00245700245700246
TF TF:M12350 Factor: zbtb2; motif: NTTTCCGGTAAN 0.0187921949394652 418 33 5 0.151515151515152 0.0119617224880383
TF TF:M02072 Factor: Pet-1; motif: ACCGGAWRTN 0.019071565592973 2395 50 15 0.3 0.00626304801670146
TF TF:M09918 Factor: Pet-1; motif: GCNGGAAGYG 0.0209786640712732 13610 38 35 0.921052631578947 0.00257163850110213
TF TF:M02012_1 Factor: HIF-1alpha; motif: NCACGT; match class: 1 0.0209786640712732 1770 95 19 0.2 0.0107344632768362
TF TF:M04694 Factor: NRF-1; motif: CNCTGCGCATGCGC 0.0218638131752955 1548 76 15 0.197368421052632 0.00968992248062015
TF TF:M11033 Factor: Six-2; motif: NCGTATCRYN 0.0220732072037029 8598 28 21 0.75 0.00244242847173761
TF TF:M09641 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN 0.0220732072037029 3222 76 24 0.315789473684211 0.0074487895716946
TF TF:M08418 Factor: TEF-3:Elk-1; motif: RMATWCCGGAWGT 0.0220732072037029 11758 19 18 0.947368421052632 0.00153087259738051
TF TF:M11448 Factor: Elf-1; motif: NANGCGGAAGTN 0.022268554056832 7600 90 50 0.555555555555556 0.00657894736842105
TF TF:M08623_1 Factor: rfx3:SRF; motif: TRGCAACNNNNNCCNWATANGGN; match class: 1 0.0234999344358286 8140 79 47 0.594936708860759 0.00577395577395577
TF TF:M11414_1 Factor: GABP-alpha; motif: NACCGGAAGTN; match class: 1 0.0243866069467997 442 50 6 0.12 0.0135746606334842
TF TF:M02070 Factor: TEL1; motif: CNCGGAANNN 0.0261235681246978 10837 20 18 0.9 0.00166097628494971
TF TF:M09613_1 Factor: Fli-1; motif: RCMGGAAGYGNNN; match class: 1 0.0262444810559009 866 47 8 0.170212765957447 0.0092378752886836
TF TF:M00341_1 Factor: GABP; motif: VCCGGAAGNGCR; match class: 1 0.0269224636708593 2318 93 22 0.236559139784946 0.0094909404659189
TF TF:M07229 Factor: STAT3; motif: NTTCYKGGAAN 0.0269224636708593 3717 64 23 0.359375 0.0061877858488028
TF TF:M08470 Factor: Fli-1:Dlx-2; motif: RNCGGAARYAATTA 0.0271271007059813 5930 73 35 0.479452054794521 0.00590219224283305
TF TF:M09944 Factor: HIF-1alpha; motif: GNACGTGM 0.0271271007059813 5581 77 35 0.454545454545455 0.00627127754882638
TF TF:M10468 Factor: ZBRK1; motif: NGNNNGGTNAWAAAARRGCNG 0.0271271007059813 10941 92 66 0.717391304347826 0.00603235536057033
TF TF:M07209_1 Factor: ELK4; motif: NCRCTTCCGGN; match class: 1 0.0288713757790117 84 47 3 0.0638297872340425 0.0357142857142857
TF TF:M08453 Factor: ERF:SREBP-2; motif: NSCGGAARTCACGTGAT 0.0288713757790117 10112 95 64 0.673684210526316 0.00632911392405063
TF TF:M08231_1 Factor: Elk-1:T-bet; motif: TCACACCGGAAGNN; match class: 1 0.0288713757790117 1581 93 17 0.182795698924731 0.010752688172043
TF TF:M08757 Factor: nerf; motif: AAMCCGGAAGTN 0.0289634322935239 715 33 6 0.181818181818182 0.00839160839160839
TF TF:M03989 Factor: FLI1; motif: ACCGGAAATCCGGT 0.0310136383258667 10442 78 55 0.705128205128205 0.00526719019344953
TF TF:M02111 Factor: NR1B2; motif: NTGACCY 0.0314991645892877 9671 71 48 0.676056338028169 0.0049632923172371
TF TF:M12085 Factor: ZNF501; motif: NNNCSACGCGAACAC 0.0314991645892877 8467 95 56 0.589473684210526 0.00661391283807724
TF TF:M03821 Factor: ER-beta; motif: ANNSTGACCYRGNN 0.0323476811334999 6456 38 22 0.578947368421053 0.00340768277571252
TF TF:M11054_1 Factor: Hey2; motif: NGCACGYGYN; match class: 1 0.0328395680511847 808 41 7 0.170731707317073 0.00866336633663366
TF TF:M09664 Factor: STAT3; motif: NTTCCYGGAAN 0.0328395680511847 5587 89 39 0.438202247191011 0.00698049042419903
TF TF:M01208_1 Factor: FLI-1; motif: CMGGAWGTSAN; match class: 1 0.0328395680511847 1286 50 10 0.2 0.00777604976671851
TF TF:M02077 Factor: Spic; motif: NGNGGAASTN 0.0331771720657147 8354 59 37 0.627118644067797 0.00442901604022025
TF TF:M04881 Factor: ER-alpha; motif: ARGSTGACC 0.0337673048220972 3973 13 8 0.615384615384615 0.00201359174427385
TF TF:M09608 Factor: Erg; motif: NNACCGGAARTSN 0.03381134777515 8152 41 27 0.658536585365854 0.00331207065750736
TF TF:M11845_1 Factor: ER-alpha; motif: NAGGTCANSNTGACCYN; match class: 1 0.0341011375296667 1742 94 18 0.191489361702128 0.0103329506314581
TF TF:M02055 Factor: ESE-1; motif: NSMGGAARTN 0.0343358663905853 7559 90 49 0.544444444444444 0.00648233893372139
TF TF:M01214 Factor: ESE-1; motif: NSMGGAARTN 0.0343358663905853 7559 90 49 0.544444444444444 0.00648233893372139
TF TF:M11393_1 Factor: Erg; motif: NACCGGATATCCGGTN; match class: 1 0.0343358663905853 13665 18 18 1 0.0013172338090011
TF TF:M08467 Factor: Erm:HOXB13; motif: RSCGGAWGTNRTWAA 0.036161890557224 706 7 3 0.428571428571429 0.00424929178470255
TF TF:M11382 Factor: ESE-1; motif: NWTRCGGAWGCN 0.036161890557224 10339 89 61 0.685393258426966 0.00589999032788471
TF TF:M00144_1 Factor: Pax-5; motif: RRMSWGANWYCTNRAGCGKRACSRYNSM; match class: 1 0.0361831001339564 7128 79 42 0.531645569620253 0.00589225589225589
TF TF:M08980 Factor: VDR:RXR-ALPHA; motif: NRGGTCANNNGGTTCNN 0.0365811612684166 10442 18 16 0.888888888888889 0.00153227351082168
TF TF:M00678_1 Factor: Tel-2; motif: YTACTTCCTG; match class: 1 0.0367388878802869 874 50 8 0.16 0.0091533180778032
TF TF:M08222_1 Factor: Elk-1:HOXB13; motif: ACCGGAAGTNGTAAAN; match class: 1 0.0368813978829846 2063 50 13 0.26 0.00630150266602036
TF TF:M11436_1 Factor: SAP-1; motif: NRNCGGAWRYN; match class: 1 0.0368813978829846 136 33 3 0.0909090909090909 0.0220588235294118
TF TF:M11420_1 Factor: ER81; motif: NACCGGAAGTN; match class: 1 0.0368813978829846 494 50 6 0.12 0.0121457489878543
TF TF:M11054 Factor: Hey2; motif: NGCACGYGYN 0.0371974737501089 3318 95 28 0.294736842105263 0.00843881856540084
TF TF:M02064 Factor: c-ets-2; motif: ACCGGAWRTN 0.0372863845166576 10939 93 66 0.709677419354839 0.00603345826858031
TF TF:M01023 Factor: HSF1; motif: NTTCTRGAAVNTTCTYM 0.037326707613264 2721 88 23 0.261363636363636 0.00845277471517824
TF TF:M07281 Factor: EKLF; motif: NCCMCACCCW 0.0383168310975239 798 22 5 0.227272727272727 0.006265664160401
TF TF:M03876 Factor: Kaiso; motif: GCMGGGRGCRGS 0.0386997006677751 13622 94 78 0.829787234042553 0.00572603141976215
TF TF:M08826 Factor: NF-E4; motif: GTGAGGS 0.0387501064554569 11318 24 21 0.875 0.00185545149319668
TF TF:M01167 Factor: SAP-1a; motif: NACCGGAAGTV 0.0394269009288186 1948 93 19 0.204301075268817 0.00975359342915811
TF TF:M02061_1 Factor: ERF; motif: ACCGGAARYN; match class: 1 0.0396922933735784 363 47 5 0.106382978723404 0.0137741046831956
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.040085883852173 10055 20 17 0.85 0.0016907011437096
TF TF:M11424 Factor: Erm; motif: NNSCGGAWGYN 0.0401279464524742 8149 55 34 0.618181818181818 0.00417229107865996
TF TF:M03967 Factor: ELF3; motif: WACCCGGAAGTAN 0.0401318155349839 7610 73 41 0.561643835616438 0.00538764783180026
TF TF:M08868_1 Factor: ARNTLIKE; motif: NNNSCACGTG; match class: 1 0.0401441033419474 2849 95 25 0.263157894736842 0.00877500877500877
TF TF:M11399 Factor: Fli-1; motif: NACCGGAWWTCCGGTY 0.0406346823260039 12977 80 65 0.8125 0.00500886183247284
TF TF:M01243 Factor: MTF-1; motif: TGCGCAC 0.0409585669765483 2835 47 15 0.319148936170213 0.00529100529100529
TF TF:M04918_1 Factor: Egr-1; motif: ACCGCCC; match class: 1 0.0413579432006897 1296 9 4 0.444444444444444 0.00308641975308642
TF TF:M09944_1 Factor: HIF-1alpha; motif: GNACGTGM; match class: 1 0.0417784577404447 1384 41 9 0.219512195121951 0.0065028901734104
TF TF:M01595_1 Factor: STAT3; motif: NNTTCCRGGAANNNNN; match class: 1 0.0420630544138863 2700 64 18 0.28125 0.00666666666666667
TF TF:M04474 Factor: COUP-TF1; motif: GRGGTCAN 0.0423931765819039 951 70 10 0.142857142857143 0.010515247108307
TF TF:M03838 Factor: Otx1; motif: WASTAATCC 0.042443347048159 527 66 7 0.106060606060606 0.0132827324478178
TF TF:M06860 Factor: ZNF549; motif: NCTTTTWTGGGA 0.0425078447516793 65 74 3 0.0405405405405405 0.0461538461538462
TF TF:M10115_1 Factor: LRF; motif: NRGGGKCKY; match class: 1 0.042742916547736 2326 9 5 0.555555555555556 0.00214961306964746
TF TF:M11655 Factor: HSF1; motif: NGAANGTTCKRGAAN 0.042742916547736 1207 75 12 0.16 0.00994200497100249
TF TF:M01208 Factor: FLI-1; motif: CMGGAWGTSAN 0.0433288700848874 6232 90 42 0.466666666666667 0.00673940949935815
TF TF:M08289 Factor: Fli-1:Max; motif: NCCGGAAACACGTGN 0.0433430394616587 9971 47 34 0.723404255319149 0.00340988867716377
TF TF:M04070_1 Factor: POU2F1; motif: NWTATGCWAATN; match class: 1 0.0442384642189301 341 15 3 0.2 0.00879765395894428
TF TF:M11433 Factor: Elk-1; motif: NRCCGGAAGTN 0.0442384642189301 7679 90 49 0.544444444444444 0.00638103919781222
TF TF:M11436 Factor: SAP-1; motif: NRNCGGAWRYN 0.0447348595790131 1431 33 8 0.242424242424242 0.00559049615653389
TF TF:M00799_1 Factor: Myc; motif: CACGTGS; match class: 1 0.0447348595790131 2722 95 24 0.252631578947368 0.00881704628949302
TF TF:M08341_1 Factor: HOXB2:Elk-1; motif: TAATKRCCGGAAGTN; match class: 1 0.0447348595790131 1317 52 10 0.192307692307692 0.00759301442672741
TF TF:M11402 Factor: Fli-1; motif: NACCGGAARTN 0.0449868285662163 3885 50 19 0.38 0.00489060489060489
TF TF:M09817 Factor: PAX5; motif: RNGCGTGACCNN 0.0453449181262981 12511 77 61 0.792207792207792 0.00487570937574934
TF TF:M11480_1 Factor: AP-2alpha; motif: NGCCTSAGGCN; match class: 1 0.0461591612409943 5842 21 13 0.619047619047619 0.00222526532009586
TF TF:M09817_1 Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 0.0461688325497944 6170 10 8 0.8 0.00129659643435981
TF TF:M01973_1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 0.0482348721686163 2398 90 21 0.233333333333333 0.00875729774812344
TF TF:M11387 Factor: elf5; motif: NNNNMGGAAGTN 0.0486747672672125 2598 3 3 1 0.00115473441108545
TF TF:M04743_1 Factor: c-Myc; motif: NSCACGTGGN; match class: 1 0.0494049741907736 3081 76 22 0.289473684210526 0.00714053878610841
TF TF:M08911_1 Factor: CTCF; motif: NCCRSTAGGGGGCGC; match class: 1 0.0496558254245757 3934 14 8 0.571428571428571 0.00203355363497712

pEpi24 transcription factor target enrichment of top program genes

TF enrichment of pEpi24
Possible regulators of activation of pEpi24 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.