pEpiTd20 program activity among Epithelial cells

Activation of pEpiTd20
pEpiTd20 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTd20 by different cell subtypes
pEpiTd20 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTd20 top program genes

Top genes of pEpiTd20 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTd20 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTd20
pEpiTd20 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:178 Respiratory chain complex I (holoenzyme), mitochondrial 0.00749914167871625 44 7 3 0.428571428571429 0.0681818181818182
GO:BP GO:0006119 oxidative phosphorylation 4.00561228358307e-09 151 12 7 0.583333333333333 0.0463576158940397
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 1.57055172638856e-08 99 12 6 0.5 0.0606060606060606
GO:BP GO:0042773 ATP synthesis coupled electron transport 1.57055172638856e-08 100 12 6 0.5 0.06
GO:BP GO:0022904 respiratory electron transport chain 3.0755498737924e-08 117 12 6 0.5 0.0512820512820513
GO:BP GO:0046034 ATP metabolic process 1.39355813742303e-07 314 12 7 0.583333333333333 0.0222929936305732
GO:BP GO:0022900 electron transport chain 2.79602156976125e-07 180 12 6 0.5 0.0333333333333333
GO:BP GO:0045333 cellular respiration 3.53656980939387e-07 192 12 6 0.5 0.03125
GO:BP GO:0015990 electron transport coupled proton transport 1.12940009675461e-06 5 102 4 0.0392156862745098 0.8
GO:BP GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient 1.12940009675461e-06 5 102 4 0.0392156862745098 0.8
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 2.67264083735874e-06 289 12 6 0.5 0.0207612456747405
GO:BP GO:0006091 generation of precursor metabolites and energy 2.67264083735874e-06 538 12 7 0.583333333333333 0.0130111524163569
GO:BP GO:0009060 aerobic respiration 4.69568430766077e-05 89 12 4 0.333333333333333 0.0449438202247191
GO:BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 0.0001609589997456 56 7 3 0.428571428571429 0.0535714285714286
GO:BP GO:0055114 obsolete oxidation-reduction process 0.000350279552186108 745 7 5 0.714285714285714 0.00671140939597315
GO:BP GO:1902600 proton transmembrane transport 0.000365847325063088 157 12 4 0.333333333333333 0.0254777070063694
GO:BP GO:0006414 translational elongation 0.00779347355492339 141 11 3 0.272727272727273 0.0212765957446809
GO:BP GO:0016310 phosphorylation 0.0142755465116261 2138 12 7 0.583333333333333 0.00327408793264733
GO:BP GO:0006412 translation 0.0162768077714936 764 21 6 0.285714285714286 0.00785340314136126
GO:BP GO:0043043 peptide biosynthetic process 0.0179729264391699 790 21 6 0.285714285714286 0.00759493670886076
GO:BP GO:0006415 translational termination 0.0179729264391699 104 51 4 0.0784313725490196 0.0384615384615385
GO:BP GO:0006979 response to oxidative stress 0.0264660004631573 466 6 3 0.5 0.00643776824034335
GO:BP GO:0043933 protein-containing complex subunit organization 0.0377684499487654 1963 15 7 0.466666666666667 0.00356597045338767
GO:BP GO:0043604 amide biosynthetic process 0.0377684499487654 932 21 6 0.285714285714286 0.00643776824034335
GO:BP GO:0006518 peptide metabolic process 0.0415707577713593 955 21 6 0.285714285714286 0.00628272251308901
GO:BP GO:0007005 mitochondrion organization 0.0447333290757876 561 48 7 0.145833333333333 0.0124777183600713
GO:CC GO:0098803 respiratory chain complex 2.51871538263685e-09 86 12 6 0.5 0.0697674418604651
GO:CC GO:0098800 inner mitochondrial membrane protein complex 2.54152016811917e-09 146 9 6 0.666666666666667 0.0410958904109589
GO:CC GO:0070469 respirasome 2.54152016811917e-09 103 12 6 0.5 0.058252427184466
GO:CC GO:0005746 mitochondrial respirasome 3.23926047320515e-09 89 7 5 0.714285714285714 0.0561797752808989
GO:CC GO:0098798 mitochondrial protein-containing complex 3.23926047320515e-09 270 11 7 0.636363636363636 0.0259259259259259
GO:CC GO:0005743 mitochondrial inner membrane 6.66665797122647e-09 503 12 8 0.666666666666667 0.0159045725646123
GO:CC GO:1990204 oxidoreductase complex 7.80776776964921e-09 113 7 5 0.714285714285714 0.0442477876106195
GO:CC GO:0019866 organelle inner membrane 1.24224381802589e-08 564 12 8 0.666666666666667 0.0141843971631206
GO:CC GO:0031966 mitochondrial membrane 1.01101591973882e-07 746 12 8 0.666666666666667 0.0107238605898123
GO:CC GO:0005740 mitochondrial envelope 1.53286045461036e-07 797 12 8 0.666666666666667 0.0100376411543287
GO:CC GO:0005739 mitochondrion 1.89806539325587e-06 1673 12 9 0.75 0.00537955768081291
GO:CC GO:0031975 envelope 3.68760833237111e-06 1237 12 8 0.666666666666667 0.00646725949878739
GO:CC GO:0031967 organelle envelope 3.68760833237111e-06 1237 12 8 0.666666666666667 0.00646725949878739
GO:CC GO:0030964 NADH dehydrogenase complex 1.52054658126554e-05 51 7 3 0.428571428571429 0.0588235294117647
GO:CC GO:0045271 respiratory chain complex I 1.52054658126554e-05 51 7 3 0.428571428571429 0.0588235294117647
GO:CC GO:0005747 mitochondrial respiratory chain complex I 1.52054658126554e-05 51 7 3 0.428571428571429 0.0588235294117647
GO:CC GO:0070069 cytochrome complex 2.57595159292501e-05 34 12 3 0.25 0.0882352941176471
GO:CC GO:0098796 membrane protein complex 9.70771286630929e-05 1322 12 7 0.583333333333333 0.00529500756429652
GO:CC GO:0032991 protein-containing complex 0.000192173497137937 5548 75 40 0.533333333333333 0.00720980533525595
GO:CC GO:1902494 catalytic complex 0.000657159956172622 1441 7 5 0.714285714285714 0.00346981263011797
GO:CC GO:0071014 post-mRNA release spliceosomal complex 0.000832624404938924 13 116 3 0.0258620689655172 0.230769230769231
GO:CC GO:0005840 ribosome 0.00355501587106045 245 11 3 0.272727272727273 0.0122448979591837
GO:CC GO:0031090 organelle membrane 0.00433107179564527 3612 12 8 0.666666666666667 0.00221483942414175
GO:CC GO:1990904 ribonucleoprotein complex 0.00519925728144076 688 78 10 0.128205128205128 0.0145348837209302
GO:CC GO:0042571 immunoglobulin complex, circulating 0.0237213924030558 77 68 3 0.0441176470588235 0.038961038961039
GO:CC GO:0140513 nuclear protein-containing complex 0.0376515536974817 1249 78 12 0.153846153846154 0.00960768614891913
GO:CC GO:0005759 mitochondrial matrix 0.0411270674590266 479 15 3 0.2 0.00626304801670146
GO:CC GO:0000792 heterochromatin 0.048887661138349 76 98 3 0.0306122448979592 0.0394736842105263
GO:MF GO:0009055 electron transfer activity 8.86362821090178e-08 148 12 6 0.5 0.0405405405405405
GO:MF GO:0050136 NADH dehydrogenase (quinone) activity 5.25985868198877e-05 46 7 3 0.428571428571429 0.0652173913043478
GO:MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 5.25985868198877e-05 46 7 3 0.428571428571429 0.0652173913043478
GO:MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity 5.25985868198877e-05 49 7 3 0.428571428571429 0.0612244897959184
GO:MF GO:0003954 NADH dehydrogenase activity 5.25985868198877e-05 46 7 3 0.428571428571429 0.0652173913043478
GO:MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 8.54578600801668e-05 61 7 3 0.428571428571429 0.0491803278688525
GO:MF GO:0016491 oxidoreductase activity 0.000147807670917805 771 7 5 0.714285714285714 0.00648508430609598
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.000350865737680175 107 7 3 0.428571428571429 0.0280373831775701
GO:MF GO:0015078 proton transmembrane transporter activity 0.00305345918387911 125 12 3 0.25 0.024
GO:MF GO:0003723 RNA binding 0.00581732171717497 1943 81 20 0.246913580246914 0.0102933607822954
GO:MF GO:0004177 aminopeptidase activity 0.0179106875133864 39 80 3 0.0375 0.0769230769230769
GO:MF GO:0003824 catalytic activity 0.0495307901604748 5896 115 51 0.443478260869565 0.00864993215739484
GO:MF GO:0034987 immunoglobulin receptor binding 0.0495307901604748 79 68 3 0.0441176470588235 0.0379746835443038
HP HP:0000576 Centrocecal scotoma 4.04784376199301e-08 12 102 8 0.0784313725490196 0.666666666666667
HP HP:0012766 Widened cerebral subarachnoid space 1.35920916229932e-07 8 29 5 0.172413793103448 0.625
HP HP:0025268 Stuttering 1.35920916229932e-07 12 85 7 0.0823529411764706 0.583333333333333
HP HP:0200125 Mitochondrial respiratory chain defects 1.35920916229932e-07 18 12 5 0.416666666666667 0.277777777777778
HP HP:0001427 Mitochondrial inheritance 1.35920916229932e-07 18 12 5 0.416666666666667 0.277777777777778
HP HP:0001112 Leber optic atrophy 1.35920916229932e-07 10 102 7 0.0686274509803922 0.7
HP HP:0007763 Retinal telangiectasia 1.3927154047891e-07 19 12 5 0.416666666666667 0.263157894736842
HP HP:0007768 Central retinal vessel vascular tortuosity 1.41520328164651e-07 11 102 7 0.0686274509803922 0.636363636363636
HP HP:0000631 Retinal arterial tortuosity 1.41520328164651e-07 11 102 7 0.0686274509803922 0.636363636363636
HP HP:0007327 Mixed demyelinating and axonal polyneuropathy 1.58456150539186e-07 9 29 5 0.172413793103448 0.555555555555556
HP HP:0002401 Stroke-like episode 1.80576756417347e-07 15 121 8 0.0661157024793388 0.533333333333333
HP HP:0004309 Ventricular preexcitation 2.33872685380455e-07 23 12 5 0.416666666666667 0.217391304347826
HP HP:0005157 Concentric hypertrophic cardiomyopathy 2.4269109324236e-07 10 29 5 0.172413793103448 0.5
HP HP:0000590 Progressive external ophthalmoplegia 3.90349291238914e-07 26 12 5 0.416666666666667 0.192307692307692
HP HP:0000622 Blurred vision 9.76431859202665e-07 32 12 5 0.416666666666667 0.15625
HP HP:0007067 Distal peripheral sensory neuropathy 9.76431859202665e-07 13 29 5 0.172413793103448 0.384615384615385
HP HP:0007924 Slow decrease in visual acuity 9.76431859202665e-07 32 12 5 0.416666666666667 0.15625
HP HP:0001345 Psychotic mentation 1.36778986662588e-06 14 29 5 0.172413793103448 0.357142857142857
HP HP:0100027 Recurrent pancreatitis 1.93502702760261e-06 15 29 5 0.172413793103448 0.333333333333333
HP HP:0003200 Ragged-red muscle fibers 2.68373863751843e-06 40 12 5 0.416666666666667 0.125
HP HP:0012429 Aplasia/Hypoplasia of the cerebral white matter 2.77498398750574e-06 19 88 7 0.0795454545454545 0.368421052631579
HP HP:0012841 Retinal vascular tortuosity 2.77498398750574e-06 41 12 5 0.416666666666667 0.121951219512195
HP HP:0012707 Elevated brain lactate level by MRS 3.12852038817951e-06 17 29 5 0.172413793103448 0.294117647058824
HP HP:0007159 Fluctuations in consciousness 3.12852038817951e-06 17 29 5 0.172413793103448 0.294117647058824
HP HP:0000603 Central scotoma 3.96042380426895e-06 45 12 5 0.416666666666667 0.111111111111111
HP HP:0025045 Abnormal brain lactate level by MRS 3.9807340946595e-06 18 29 5 0.172413793103448 0.277777777777778
HP HP:0001716 Wolff-Parkinson-White syndrome 5.17911234008042e-06 19 29 5 0.172413793103448 0.263157894736842
HP HP:0005116 Arterial tortuosity 6.629132450291e-06 20 29 5 0.172413793103448 0.25
HP HP:0002174 Postural tremor 7.19637779745161e-06 52 12 5 0.416666666666667 0.0961538461538462
HP HP:0000544 External ophthalmoplegia 9.27485332499078e-06 55 12 5 0.416666666666667 0.0909090909090909
HP HP:0004948 Vascular tortuosity 1.00795128494868e-05 22 29 5 0.172413793103448 0.227272727272727
HP HP:0004389 Intestinal pseudo-obstruction 1.24211879101569e-05 23 29 5 0.172413793103448 0.217391304347826
HP HP:0001045 Vitiligo 1.78068554522265e-05 25 12 4 0.333333333333333 0.16
HP HP:0002331 Recurrent paroxysmal headache 2.03962866546803e-05 26 12 4 0.333333333333333 0.153846153846154
HP HP:0003287 Abnormality of mitochondrial metabolism 2.93050163277089e-05 139 12 6 0.5 0.0431654676258993
HP HP:0010794 Impaired visuospatial constructive cognition 3.04720948718926e-05 29 12 4 0.333333333333333 0.137931034482759
HP HP:0000575 Scotoma 3.39644365277719e-05 74 12 5 0.416666666666667 0.0675675675675676
HP HP:0002572 Episodic vomiting 4.24044432936266e-05 32 12 4 0.333333333333333 0.125
HP HP:0012705 Abnormal metabolic brain imaging by MRS 4.24044432936266e-05 32 12 4 0.333333333333333 0.125
HP HP:0007302 Bipolar affective disorder 5.31673212093227e-05 34 12 4 0.333333333333333 0.117647058823529
HP HP:0002135 Basal ganglia calcification 5.70872746213307e-05 35 12 4 0.333333333333333 0.114285714285714
HP HP:0100754 Mania 5.70872746213307e-05 35 12 4 0.333333333333333 0.114285714285714
HP HP:0012103 Abnormality of the mitochondrion 6.12161267305966e-05 163 12 6 0.5 0.0368098159509202
HP HP:0000408 Progressive sensorineural hearing impairment 6.12161267305966e-05 36 12 4 0.333333333333333 0.111111111111111
HP HP:0000829 Hypoparathyroidism 6.70148603807389e-05 37 12 4 0.333333333333333 0.108108108108108
HP HP:0008316 Abnormal mitochondria in muscle tissue 7.31657322335139e-05 38 12 4 0.333333333333333 0.105263157894737
HP HP:0012377 Hemianopia 9.78216867456518e-05 41 12 4 0.333333333333333 0.0975609756097561
HP HP:0000751 Personality changes 0.000116389846373523 43 12 4 0.333333333333333 0.0930232558139535
HP HP:0000529 Progressive visual loss 0.000121697681767338 101 12 5 0.416666666666667 0.0495049504950495
HP HP:0001730 Progressive hearing impairment 0.000122731428266748 44 12 4 0.333333333333333 0.0909090909090909
HP HP:0000097 Focal segmental glomerulosclerosis 0.0001268981459824 45 12 4 0.333333333333333 0.0888888888888889
HP HP:0002922 Increased CSF protein 0.0001268981459824 45 12 4 0.333333333333333 0.0888888888888889
HP HP:0100651 Type I diabetes mellitus 0.0001268981459824 45 12 4 0.333333333333333 0.0888888888888889
HP HP:0004308 Ventricular arrhythmia 0.00014035450538928 106 12 5 0.416666666666667 0.0471698113207547
HP HP:0025456 Abnormal CSF protein level 0.000145968639394814 47 12 4 0.333333333333333 0.0851063829787234
HP HP:0000114 Proximal tubulopathy 0.000153820525298788 48 12 4 0.333333333333333 0.0833333333333333
HP HP:0000630 Abnormal retinal artery morphology 0.000205055060343668 52 12 4 0.333333333333333 0.0769230769230769
HP HP:0030085 Abnormal CSF lactate level 0.000210130296401016 91 15 5 0.333333333333333 0.0549450549450549
HP HP:0002490 Increased CSF lactate 0.000210130296401016 91 15 5 0.333333333333333 0.0549450549450549
HP HP:0003737 Mitochondrial myopathy 0.000227293189443009 54 12 4 0.333333333333333 0.0740740740740741
HP HP:0031546 Cardiac conduction abnormality 0.000243077923881125 123 12 5 0.416666666666667 0.040650406504065
HP HP:0001138 Optic neuropathy 0.000261581486026842 57 12 4 0.333333333333333 0.0701754385964912
HP HP:0002151 Increased serum lactate 0.000261683108005167 172 15 6 0.4 0.0348837209302326
HP HP:0001271 Polyneuropathy 0.000272422283357537 58 12 4 0.333333333333333 0.0689655172413793
HP HP:0008619 Bilateral sensorineural hearing impairment 0.000341296931547267 62 12 4 0.333333333333333 0.0645161290322581
HP HP:0001009 Telangiectasia 0.000341804894398226 135 12 5 0.416666666666667 0.037037037037037
HP HP:0011767 Abnormality of the parathyroid physiology 0.000354076405579582 63 12 4 0.333333333333333 0.0634920634920635
HP HP:3000036 Abnormality of head blood vessel 0.000372110032496176 64 12 4 0.333333333333333 0.0625
HP HP:0025454 Abnormal CSF metabolite level 0.000422701425154517 110 15 5 0.333333333333333 0.0454545454545455
HP HP:0003800 Muscle abnormality related to mitochondrial dysfunction 0.000483334303120544 69 12 4 0.333333333333333 0.0579710144927536
HP HP:0002381 Aphasia 0.00051524694677676 71 12 4 0.333333333333333 0.0563380281690141
HP HP:0002579 Gastrointestinal dysmotility 0.00051524694677676 71 12 4 0.333333333333333 0.0563380281690141
HP HP:0030895 Abnormal gastrointestinal motility 0.00051524694677676 71 12 4 0.333333333333333 0.0563380281690141
HP HP:0007141 Sensorimotor neuropathy 0.00053820701878879 72 12 4 0.333333333333333 0.0555555555555556
HP HP:0000096 Glomerular sclerosis 0.000618218758018345 75 12 4 0.333333333333333 0.0533333333333333
HP HP:0000828 Abnormality of the parathyroid gland 0.000618218758018345 75 12 4 0.333333333333333 0.0533333333333333
HP HP:0030956 Abnormality of cardiovascular system electrophysiology 0.000631670042881403 424 12 7 0.583333333333333 0.0165094339622642
HP HP:0001733 Pancreatitis 0.000636644836834607 76 12 4 0.333333333333333 0.0526315789473684
HP HP:0002345 Action tremor 0.000641693164344519 160 12 5 0.416666666666667 0.03125
HP HP:0005162 Abnormal left ventricular function 0.000648210446086707 77 12 4 0.333333333333333 0.051948051948052
HP HP:0000519 Developmental cataract 0.000692454156856599 126 15 5 0.333333333333333 0.0396825396825397
HP HP:0001712 Left ventricular hypertrophy 0.000787994865040724 82 12 4 0.333333333333333 0.0487804878048781
HP HP:0003546 Exercise intolerance 0.000787994865040724 82 12 4 0.333333333333333 0.0487804878048781
HP HP:0001269 Hemiparesis 0.000898816249267362 85 12 4 0.333333333333333 0.0470588235294118
HP HP:0012704 Widened subarachnoid space 0.00102004611325539 88 12 4 0.333333333333333 0.0454545454545455
HP HP:0030872 Abnormal cardiac ventricular function 0.00112905096283219 91 12 4 0.333333333333333 0.043956043956044
HP HP:0410263 Brain imaging abnormality 0.00129828017417558 95 12 4 0.333333333333333 0.0421052631578947
HP HP:0000112 Nephropathy 0.00143881405053706 98 12 4 0.333333333333333 0.0408163265306122
HP HP:0001123 Visual field defect 0.00152672863197208 199 12 5 0.416666666666667 0.0251256281407035
HP HP:0004374 Hemiplegia/hemiparesis 0.00152672863197208 199 12 5 0.416666666666667 0.0251256281407035
HP HP:0000124 Renal tubular dysfunction 0.00157426345483659 101 12 4 0.333333333333333 0.0396039603960396
HP HP:0001711 Abnormal left ventricle morphology 0.00159193207080054 102 12 4 0.333333333333333 0.0392156862745098
HP HP:0004303 Abnormal muscle fiber morphology 0.0016810607796387 205 12 5 0.416666666666667 0.024390243902439
HP HP:0000709 Psychosis 0.00168713056685765 104 12 4 0.333333333333333 0.0384615384615385
HP HP:0002076 Migraine 0.00171300130446378 105 12 4 0.333333333333333 0.0380952380952381
HP HP:0000572 Visual loss 0.00171300130446378 207 12 5 0.416666666666667 0.0241545893719807
HP HP:0008046 Abnormal retinal vascular morphology 0.00172473963748101 208 12 5 0.416666666666667 0.0240384615384615
HP HP:0003128 Lactic acidosis 0.00173248353493949 161 15 5 0.333333333333333 0.031055900621118
HP HP:0010783 Erythema 0.00221434607299443 113 12 4 0.333333333333333 0.0353982300884956
HP HP:0001714 Ventricular hypertrophy 0.00268471751407127 119 12 4 0.333333333333333 0.0336134453781513
HP HP:0033578 Pre-capillary pulmonary hypertension 0.00288348546101818 123 12 4 0.333333333333333 0.032520325203252
HP HP:0004890 Elevated pulmonary artery pressure 0.00288348546101818 123 12 4 0.333333333333333 0.032520325203252
HP HP:0002354 Memory impairment 0.00288348546101818 123 12 4 0.333333333333333 0.032520325203252
HP HP:0012703 Abnormal subarachnoid space morphology 0.00288348546101818 122 12 4 0.333333333333333 0.0327868852459016
HP HP:0002092 Pulmonary arterial hypertension 0.00288348546101818 123 12 4 0.333333333333333 0.032520325203252
HP HP:0011675 Arrhythmia 0.00288348546101818 381 12 6 0.5 0.015748031496063
HP HP:0002514 Cerebral calcification 0.00288348546101818 123 12 4 0.333333333333333 0.032520325203252
HP HP:0000602 Ophthalmoplegia 0.00369719963696074 249 12 5 0.416666666666667 0.0200803212851406
HP HP:0012091 Abnormality of pancreas physiology 0.00415132313485967 136 12 4 0.333333333333333 0.0294117647058824
HP HP:0001297 Stroke 0.00429200707545692 138 12 4 0.333333333333333 0.0289855072463768
HP HP:0002134 Abnormality of the basal ganglia 0.004341705300759 201 15 5 0.333333333333333 0.0248756218905473
HP HP:0003477 Peripheral axonal neuropathy 0.00455879149503405 141 12 4 0.333333333333333 0.0283687943262411
HP HP:0000044 Hypogonadotropic hypogonadism 0.0046499304897131 142 12 4 0.333333333333333 0.028169014084507
HP HP:0001644 Dilated cardiomyopathy 0.00500149058200346 145 12 4 0.333333333333333 0.0275862068965517
HP HP:0001941 Acidosis 0.00544850797175326 335 15 6 0.4 0.017910447761194
HP HP:0003829 Incomplete penetrance 0.00558073956892541 150 12 4 0.333333333333333 0.0266666666666667
HP HP:0000580 Pigmentary retinopathy 0.00567627301044762 151 12 4 0.333333333333333 0.0264900662251656
HP HP:0000597 Ophthalmoparesis 0.00580007273538607 281 12 5 0.416666666666667 0.0177935943060498
HP HP:0003198 Myopathy 0.00580007273538607 290 7 4 0.571428571428571 0.0137931034482759
HP HP:0000095 Abnormal renal glomerulus morphology 0.00656254763974949 158 12 4 0.333333333333333 0.0253164556962025
HP HP:0031263 Abnormal renal corpuscle morphology 0.00656254763974949 158 12 4 0.333333333333333 0.0253164556962025
HP HP:0030875 Abnormality of pulmonary circulation 0.00683761034153649 160 12 4 0.333333333333333 0.025
HP HP:0000726 Dementia 0.00745982479466256 164 12 4 0.333333333333333 0.024390243902439
HP HP:0004360 Abnormality of acid-base homeostasis 0.00779416514164013 363 15 6 0.4 0.0165289256198347
HP HP:0000093 Proteinuria 0.00795904793317751 168 12 4 0.333333333333333 0.0238095238095238
HP HP:0008047 Abnormality of the vasculature of the eye 0.00795904793317751 319 7 4 0.571428571428571 0.0125391849529781
HP HP:0005978 Type II diabetes mellitus 0.0080869186577441 169 12 4 0.333333333333333 0.0236686390532544
HP HP:0011017 Abnormal cellular physiology 0.00854913870418332 485 12 6 0.5 0.0123711340206186
HP HP:0000764 Peripheral axonal degeneration 0.00872186212205089 173 12 4 0.333333333333333 0.023121387283237
HP HP:0007703 Abnormality of retinal pigmentation 0.00960442817186438 319 12 5 0.416666666666667 0.0156739811912226
HP HP:0025354 Abnormal cellular phenotype 0.00999688329274335 501 12 6 0.5 0.0119760479041916
HP HP:0020129 Abnormal urine protein level 0.0101489097014584 181 12 4 0.333333333333333 0.0220994475138122
HP HP:0000763 Sensory neuropathy 0.0102932850016817 182 12 4 0.333333333333333 0.021978021978022
HP HP:0011035 Abnormal renal cortex morphology 0.0111911951930243 187 12 4 0.333333333333333 0.0213903743315508
HP HP:0001337 Tremor 0.0115266073744414 518 12 6 0.5 0.0115830115830116
HP HP:0002069 Bilateral tonic-clonic seizure 0.011808632515764 261 15 5 0.333333333333333 0.0191570881226054
HP HP:0001635 Congestive heart failure 0.0130608957487765 196 12 4 0.333333333333333 0.0204081632653061
HP HP:0100704 Cerebral visual impairment 0.014060989659186 201 12 4 0.333333333333333 0.0199004975124378
HP HP:0010766 Ectopic calcification 0.014442447088261 203 12 4 0.333333333333333 0.0197044334975369
HP HP:0012575 Abnormal nephron morphology 0.0156069019091431 208 12 4 0.333333333333333 0.0192307692307692
HP HP:0001274 Agenesis of corpus callosum 0.0160187658053853 284 15 5 0.333333333333333 0.0176056338028169
HP HP:0007700 Ocular anterior segment dysgenesis 0.0160889145815449 285 15 5 0.333333333333333 0.0175438596491228
HP HP:0003812 Phenotypic variability 0.017424527950352 410 7 4 0.571428571428571 0.00975609756097561
HP HP:0000998 Hypertrichosis 0.0174609514473425 217 12 4 0.333333333333333 0.0184331797235023
HP HP:0002315 Headache 0.0236375057405433 240 6 3 0.5 0.0125
HP HP:0001639 Hypertrophic cardiomyopathy 0.0246594474000093 244 6 3 0.5 0.0122950819672131
HP HP:0030163 Abnormal vascular physiology 0.025568645379511 248 6 3 0.5 0.0120967741935484
HP HP:0001328 Specific learning disability 0.0257301414621187 249 6 3 0.5 0.0120481927710843
HP HP:0007359 Focal-onset seizure 0.0267974532508537 253 6 3 0.5 0.0118577075098814
HP HP:0001251 Ataxia 0.027680770844221 872 12 7 0.583333333333333 0.00802752293577982
HP HP:0011276 Vascular skin abnormality 0.0316443108454327 493 7 4 0.571428571428571 0.00811359026369168
HP HP:0010549 Weakness due to upper motor neuron dysfunction 0.0369705315667048 459 12 5 0.416666666666667 0.0108932461873638
HP HP:0000648 Optic atrophy 0.0391142461964221 533 7 4 0.571428571428571 0.0075046904315197
HP HP:0004372 Reduced consciousness/confusion 0.040087729667529 366 15 5 0.333333333333333 0.0136612021857923
HP HP:0011443 Abnormality of coordination 0.0478201517752439 984 12 7 0.583333333333333 0.00711382113821138
HPA HPA:0060103 bronchus; respiratory epithelial cells[High] 0.048700408985987 1890 81 28 0.345679012345679 0.0148148148148148
HPA HPA:0170053 endometrium 2; glandular cells[High] 0.048700408985987 1282 65 18 0.276923076923077 0.0140405616224649
HPA HPA:0170253 endometrium 2; cells in endometrial stroma[High] 0.048700408985987 326 78 9 0.115384615384615 0.0276073619631902
HPA HPA:0600433 tonsil; germinal center cells[High] 0.048700408985987 1179 15 7 0.466666666666667 0.00593723494486853
HPA HPA:0110223 cervix, uterine; squamous epithelial cells[High] 0.048700408985987 986 13 6 0.461538461538462 0.00608519269776876
KEGG KEGG:00190 Oxidative phosphorylation 1.96942472463815e-08 133 12 7 0.583333333333333 0.0526315789473684
KEGG KEGG:05415 Diabetic cardiomyopathy 1.93287292558758e-07 203 12 7 0.583333333333333 0.0344827586206897
KEGG KEGG:04714 Thermogenesis 3.27145109718519e-07 232 12 7 0.583333333333333 0.0301724137931034
KEGG KEGG:05012 Parkinson disease 4.01212216577564e-07 249 12 7 0.583333333333333 0.0281124497991968
KEGG KEGG:05020 Prion disease 6.07608711908007e-07 273 12 7 0.583333333333333 0.0256410256410256
KEGG KEGG:05016 Huntington disease 1.11412361983143e-06 306 12 7 0.583333333333333 0.0228758169934641
KEGG KEGG:05014 Amyotrophic lateral sclerosis 3.02540714945394e-06 363 12 7 0.583333333333333 0.0192837465564738
KEGG KEGG:05010 Alzheimer disease 3.02540714945394e-06 369 12 7 0.583333333333333 0.018970189701897
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 1.50162251258461e-05 475 12 7 0.583333333333333 0.0147368421052632
KEGG KEGG:04723 Retrograde endocannabinoid signaling 0.00182964480447585 148 7 3 0.428571428571429 0.0202702702702703
KEGG KEGG:04260 Cardiac muscle contraction 0.00205934977752004 87 12 3 0.25 0.0344827586206897
KEGG KEGG:04932 Non-alcoholic fatty liver disease 0.00930743322170892 150 12 3 0.25 0.02
KEGG KEGG:01100 Metabolic pathways 0.0141776667716398 1490 9 6 0.666666666666667 0.00402684563758389
MIRNA MIRNA:hsa-let-7c-5p hsa-let-7c-5p 0.00131468137095994 514 12 6 0.5 0.0116731517509728
MIRNA MIRNA:hsa-let-7e-5p hsa-let-7e-5p 0.00768449821485948 608 29 8 0.275862068965517 0.0131578947368421
MIRNA MIRNA:hsa-let-7b-5p hsa-let-7b-5p 0.0135272389193409 1212 14 7 0.5 0.00577557755775578
MIRNA MIRNA:hsa-let-7a-5p hsa-let-7a-5p 0.0135272389193409 637 11 5 0.454545454545455 0.00784929356357928
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 8.48452343803286e-07 124 12 6 0.5 0.0483870967741935
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 3.2744678245825e-06 174 12 6 0.5 0.0344827586206897
REAC REAC:R-HSA-611105 Respiratory electron transport 7.21492665157825e-06 100 12 5 0.416666666666667 0.05
REAC REAC:R-HSA-72766 Translation 0.00169938110092351 292 21 6 0.285714285714286 0.0205479452054795
TF TF:M04694 Factor: NRF-1; motif: CNCTGCGCATGCGC 0.000164815174592634 1548 63 20 0.317460317460317 0.0129198966408269
TF TF:M09641 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN 0.000164815174592634 3222 54 26 0.481481481481481 0.00806952203600248
TF TF:M10018 Factor: NRF-1; motif: CNSTGCGCATGCGCNNS 0.000204106194847485 1816 63 21 0.333333333333333 0.0115638766519824
TF TF:M03922_1 Factor: SP4; motif: NWRGCCACGCCCMCTYN; match class: 1 0.000245213002925636 2143 122 34 0.278688524590164 0.0158656089594027
TF TF:M12152_1 Factor: Sp1; motif: NWRGCCACGCCCMCN; match class: 1 0.0017723494401023 2859 121 38 0.31404958677686 0.0132913606155999
TF TF:M07052_1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 1 0.0017723494401023 734 40 10 0.25 0.0136239782016349
TF TF:M00008_1 Factor: Sp1; motif: GGGGCGGGGT; match class: 1 0.00181593538422886 4937 121 54 0.446280991735537 0.0109378164877456
TF TF:M08331 Factor: GCMb:FOXI1; motif: RTAAATANGGGNN 0.00188819170785313 45 12 3 0.25 0.0666666666666667
TF TF:M03893_1 Factor: WT1; motif: GNGGGGGCGGGG; match class: 1 0.00275492217518409 3980 122 46 0.377049180327869 0.0115577889447236
TF TF:M02102_1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 0.00275492217518409 654 87 13 0.149425287356322 0.0198776758409786
TF TF:M04043 Factor: MYBL1; motif: ACCGTTAACSGY 0.00275492217518409 24 29 3 0.103448275862069 0.125
TF TF:M10018_1 Factor: NRF-1; motif: CNSTGCGCATGCGCNNS; match class: 1 0.00275492217518409 851 40 10 0.25 0.0117508813160987
TF TF:M08319 Factor: GCMa:HOXA13; motif: RTGCGGGTAATAAA 0.00275492217518409 455 43 8 0.186046511627907 0.0175824175824176
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.00283910553243692 5919 122 60 0.491803278688525 0.010136847440446
TF TF:M12151_1 Factor: Sp1; motif: NWRGCCMCGCCCMCN; match class: 1 0.00283910553243692 2548 121 34 0.28099173553719 0.0133437990580848
TF TF:M00217 Factor: USF; motif: NCACGTGN 0.0030027789937085 4108 106 42 0.39622641509434 0.0102239532619279
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.00321873735251041 3783 122 44 0.360655737704918 0.0116309807031457
TF TF:M12157_1 Factor: KLF15; motif: RCCACGCCCCCC; match class: 1 0.00321873735251041 816 121 17 0.140495867768595 0.0208333333333333
TF TF:M08320 Factor: GCMa:HOXB13; motif: RTGCGGGTMATAAAN 0.00321873735251041 837 43 10 0.232558139534884 0.01194743130227
TF TF:M02102 Factor: NRF-1; motif: YGCGCMTGCGC 0.00321873735251041 2020 91 24 0.263736263736264 0.0118811881188119
TF TF:M09765_1 Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 0.00352501769437759 3318 122 40 0.327868852459016 0.0120554550934298
TF TF:M09641_1 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN; match class: 1 0.00415011621434992 991 93 16 0.172043010752688 0.0161453077699294
TF TF:M09910_1 Factor: ER-beta; motif: RGGTCASCNTGMCCY; match class: 1 0.00448182618408944 4079 113 43 0.380530973451327 0.0105417994606521
TF TF:M07052 Factor: NRF-1; motif: GCGCMTGCGCN 0.00488991998919349 2130 52 17 0.326923076923077 0.007981220657277
TF TF:M09764 Factor: ROX; motif: GNNNCASGTGGS 0.0055459816400848 5809 120 57 0.475 0.00981236013083147
TF TF:M00428_1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 0.00625407194857962 3615 75 29 0.386666666666667 0.00802213001383126
TF TF:M03914_1 Factor: KLF16; motif: GMCACGCCCCC; match class: 1 0.00625407194857962 710 121 15 0.12396694214876 0.0211267605633803
TF TF:M00425_1 Factor: E2F; motif: TTTCGCGC; match class: 1 0.00625407194857962 5355 121 54 0.446280991735537 0.0100840336134454
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.00625407194857962 6334 122 61 0.5 0.00963056520366277
TF TF:M07387 Factor: LRF; motif: NGKGGGTSNCN 0.00625407194857962 5232 121 53 0.43801652892562 0.0101299694189602
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.00666744065978498 4320 110 43 0.390909090909091 0.0099537037037037
TF TF:M00982 Factor: KROX; motif: CCCGCCCCCRCCCC 0.00685770864151372 7815 125 72 0.576 0.00921305182341651
TF TF:M07409_1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 1 0.00725930128869773 1829 121 26 0.214876033057851 0.014215418261345
TF TF:M00801 Factor: CREB; motif: CGTCAN 0.00742075425295545 4326 59 27 0.457627118644068 0.00624133148404993
TF TF:M07129_1 Factor: Sp2; motif: GYCCCGCCYCYNNNN; match class: 1 0.00748526327309239 2422 121 31 0.256198347107438 0.0127993393889348
TF TF:M12153_1 Factor: Sp3; motif: NGCCACGCCCMCN; match class: 1 0.00748526327309239 1938 122 27 0.221311475409836 0.0139318885448916
TF TF:M01973 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC 0.00748526327309239 6167 121 59 0.487603305785124 0.0095670504297065
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.00748526327309239 5905 126 59 0.468253968253968 0.00999153259949196
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.00748526327309239 6047 126 60 0.476190476190476 0.00992227550851662
TF TF:M10692_1 Factor: HOXB6; motif: GTCGTTAN; match class: 1 0.00791984499418656 1009 15 6 0.4 0.00594648166501487
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.00791984499418656 4199 122 45 0.368852459016393 0.0107168373422243
TF TF:M04146_1 Factor: TFAP2A; motif: YGCCCNNRGGCN; match class: 1 0.00791984499418656 3800 67 27 0.402985074626866 0.00710526315789474
TF TF:M09814_1 Factor: MYCN; motif: NNCCACGTGGNN; match class: 1 0.00791984499418656 2066 111 26 0.234234234234234 0.0125847047434656
TF TF:M05958 Factor: ZNF286; motif: NTTGGCGGATGM 0.00791984499418656 51 29 3 0.103448275862069 0.0588235294117647
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.00791984499418656 3962 125 44 0.352 0.01110550227158
TF TF:M09814 Factor: MYCN; motif: NNCCACGTGGNN 0.00791984499418656 2066 111 26 0.234234234234234 0.0125847047434656
TF TF:M05660 Factor: ZNF286B; motif: NTTGGCGGATGM 0.00791984499418656 51 29 3 0.103448275862069 0.0588235294117647
TF TF:M00933_1 Factor: Sp1; motif: CCCCGCCCCN; match class: 1 0.00791984499418656 5166 122 52 0.426229508196721 0.0100658149438637
TF TF:M00807 Factor: Egr; motif: GTGGGSGCRRS 0.00791984499418656 4343 42 21 0.5 0.004835367257656
TF TF:M00055 Factor: N-Myc; motif: NNCCACGTGNNN 0.00791984499418656 4167 126 46 0.365079365079365 0.0110391168706503
TF TF:M08911_1 Factor: CTCF; motif: NCCRSTAGGGGGCGC; match class: 1 0.00806384784661772 3934 119 42 0.352941176470588 0.0106761565836299
TF TF:M04617_1 Factor: LRF; motif: NGNAGNGGGTYN; match class: 1 0.00819819984847324 1454 121 22 0.181818181818182 0.015130674002751
TF TF:M01145_1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 0.00833817065898174 3448 70 26 0.371428571428571 0.00754060324825986
TF TF:M04797 Factor: Egr-1; motif: CCGCCCMCG 0.00856436642322653 5116 121 51 0.421487603305785 0.0099687255668491
TF TF:M10435_1 Factor: Sp2; motif: GGGGCGGGG; match class: 1 0.00857251226261785 3495 121 39 0.322314049586777 0.0111587982832618
TF TF:M07063_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.00857251226261785 3495 121 39 0.322314049586777 0.0111587982832618
TF TF:M05327 Factor: WT1; motif: NGCGGGGGGGTSMMCYN 0.00867969896223202 5509 122 54 0.442622950819672 0.00980214194953712
TF TF:M00939 Factor: E2F; motif: TTTSGCGSG 0.00913713528542742 6433 114 57 0.5 0.00886056272345717
TF TF:M04617 Factor: LRF; motif: NGNAGNGGGTYN 0.00926983315651774 6164 121 58 0.479338842975207 0.00940947436729397
TF TF:M03893 Factor: WT1; motif: GNGGGGGCGGGG 0.0115071654193998 8290 122 72 0.590163934426229 0.00868516284680338
TF TF:M12186_1 Factor: BTEB4; motif: NCCACGCCCM; match class: 1 0.0115297386307446 3958 121 42 0.347107438016529 0.010611419909045
TF TF:M09971_1 Factor: GKLF; motif: WGGGYGKGGC; match class: 1 0.0115297386307446 1352 125 21 0.168 0.0155325443786982
TF TF:M02052_1 Factor: EHF; motif: CSCGGAARTN; match class: 1 0.0115297386307446 4056 43 20 0.465116279069767 0.00493096646942801
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.0115297386307446 3020 122 35 0.286885245901639 0.0115894039735099
TF TF:M01873 Factor: Egr-1; motif: GCGGGGGCGG 0.0122602059001821 6738 125 63 0.504 0.00934995547640249
TF TF:M00246 Factor: Egr-2; motif: NTGCGTRGGCGK 0.0124764894396672 6212 114 55 0.482456140350877 0.00885383129426916
TF TF:M04694_1 Factor: NRF-1; motif: CNCTGCGCATGCGC; match class: 1 0.0124764894396672 466 82 9 0.109756097560976 0.01931330472103
TF TF:M00736_1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 0.0128583336117558 4639 71 31 0.436619718309859 0.00668247467126536
TF TF:M09764_1 Factor: ROX; motif: GNNNCASGTGGS; match class: 1 0.0134978194101047 1631 70 16 0.228571428571429 0.00980993255671367
TF TF:M00430 Factor: E2F-1; motif: NTTSGCGG 0.0136663229146222 8016 16 14 0.875 0.00174650698602794
TF TF:M09967 Factor: AP-2rep; motif: NGGGGCGGGGC 0.0148093004942428 4023 121 42 0.347107438016529 0.0104399701715138
TF TF:M02036_1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 0.0149343184481993 5290 112 48 0.428571428571429 0.00907372400756144
TF TF:M09967_1 Factor: AP-2rep; motif: NGGGGCGGGGC; match class: 1 0.0151995797265474 1379 100 18 0.18 0.0130529369108049
TF TF:M01154 Factor: c-Myc; motif: KACCACGTGSYY 0.015419659842261 5313 106 46 0.433962264150943 0.00865800865800866
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.0156598985980019 3614 122 39 0.319672131147541 0.0107913669064748
TF TF:M09761 Factor: EGR1; motif: NGNGKGGGYGGNGS 0.0156598985980019 5162 121 50 0.413223140495868 0.00968616815187912
TF TF:M00919 Factor: E2F; motif: NCSCGCSAAAN 0.0156598985980019 6149 119 56 0.470588235294118 0.00910717189786957
TF TF:M11081 Factor: SREBP-1; motif: RTCRCGTGAY 0.0156598985980019 11062 61 48 0.786885245901639 0.00433917917193997
TF TF:M01830 Factor: MAX; motif: CNNGMCACGTGN 0.0157992513837013 104 22 3 0.136363636363636 0.0288461538461538
TF TF:M04869 Factor: Egr-1; motif: GCGCATGCG 0.0159572710850163 11232 59 47 0.796610169491525 0.00418447293447293
TF TF:M05439_1 Factor: RREB-1; motif: GGGWCSA; match class: 1 0.0159572710850163 3200 25 12 0.48 0.00375
TF TF:M07615_1 Factor: Sp3; motif: GGGGCGGGGSNN; match class: 1 0.0160711139287451 2885 121 33 0.272727272727273 0.0114384748700173
TF TF:M04152_1 Factor: TFAP2C; motif: NGCCCNNRGGCA; match class: 1 0.0163698089586335 5580 67 33 0.492537313432836 0.00591397849462366
TF TF:M11620 Factor: Sox-14; motif: CCGAACAATN 0.0166135537261913 538 12 4 0.333333333333333 0.00743494423791822
TF TF:M11438_1 Factor: SAP-1; motif: NTCGTAAATGCN; match class: 1 0.0170810376878942 1191 29 8 0.275862068965517 0.00671704450041982
TF TF:M01783_1 Factor: SP2; motif: GGGCGGGAC; match class: 1 0.0182734922718655 4333 122 44 0.360655737704918 0.0101546272790215
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0182734922718655 5262 126 52 0.412698412698413 0.00988217407829723
TF TF:M09645 Factor: Pax-5; motif: NNNNRNKCAGCNRAGCGTGAC 0.0188608134008065 2596 82 23 0.280487804878049 0.0088597842835131
TF TF:M08326 Factor: GCMb:Prrxl1; motif: ATRCGGGTNATTAN 0.0192195188628556 614 30 6 0.2 0.00977198697068404
TF TF:M11090 Factor: TFEA; motif: YRCACGTGACN 0.0203101074004142 6189 107 51 0.476635514018692 0.00824042656325739
TF TF:M09969_1 Factor: EKLF; motif: NGGGYGKGGCNNGG; match class: 1 0.0203101074004142 1489 122 21 0.172131147540984 0.0141034251175285
TF TF:M01253 Factor: CNOT3; motif: GGCCGCGSSS 0.0203101074004142 3926 119 40 0.336134453781513 0.0101884870096791
TF TF:M01034 Factor: Ebox; motif: NCACSTGNCN 0.0203656070733408 4854 105 42 0.4 0.00865265760197775
TF TF:M10727_1 Factor: HOXB8; motif: RTCRTTAN; match class: 1 0.0203656070733408 1379 15 6 0.4 0.00435097897026831
TF TF:M04147 Factor: TFAP2A; motif: NGCCYSAGGCN 0.0203656070733408 5095 125 50 0.4 0.0098135426889107
TF TF:M08878_1 Factor: EGR; motif: CGCCCCCGCNN; match class: 1 0.0203656070733408 3224 125 36 0.288 0.011166253101737
TF TF:M00426_1 Factor: E2F; motif: TTTSGCGS; match class: 1 0.0203656070733408 5830 116 52 0.448275862068966 0.00891938250428817
TF TF:M03925 Factor: YY2; motif: NCCGCCATNTY 0.0203656070733408 4641 126 47 0.373015873015873 0.0101271277741866
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0203656070733408 9362 122 77 0.631147540983607 0.00822473830378124
TF TF:M03867_1 Factor: c-Myc; motif: CACGTGGC; match class: 1 0.0203656070733408 2694 106 28 0.264150943396226 0.0103934669636229
TF TF:M12166_1 Factor: CPBP; motif: NGCCACGCCCN; match class: 1 0.0203656070733408 162 112 6 0.0535714285714286 0.037037037037037
TF TF:M08282 Factor: Fli-1:Prrxl1; motif: ACCGGAAGTAATTAN 0.0203656070733408 2188 14 7 0.5 0.00319926873857404
TF TF:M01861 Factor: ATF-1; motif: TNACGTCAN 0.0203656070733408 6294 43 25 0.581395348837209 0.00397203686050207
TF TF:M11245 Factor: OASIS; motif: NGCCACGTGGCR 0.0203656070733408 161 74 5 0.0675675675675676 0.031055900621118
TF TF:M12183_1 Factor: KLF14; motif: NRCCACRCCCMCN; match class: 1 0.0203656070733408 2487 125 30 0.24 0.0120627261761158
TF TF:M04059 Factor: NRF-1; motif: YGCGCATGCGCN 0.0203656070733408 1471 52 12 0.230769230769231 0.00815771583956492
TF TF:M00430_1 Factor: E2F-1; motif: NTTSGCGG; match class: 1 0.0203656070733408 2524 16 8 0.5 0.00316957210776545
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.0203656070733408 10253 59 44 0.745762711864407 0.00429142689944407
TF TF:M10574 Factor: Gbx2; motif: NYAATTAN 0.0204060569821324 614 12 4 0.333333333333333 0.00651465798045603
TF TF:M04405 Factor: Msx-1; motif: NCAATTAN 0.0204060569821324 614 12 4 0.333333333333333 0.00651465798045603
TF TF:M10573 Factor: Gbx2; motif: NYAATTAN 0.0204060569821324 614 12 4 0.333333333333333 0.00651465798045603
TF TF:M10571 Factor: Gbx2; motif: NYAATTAN 0.0204060569821324 614 12 4 0.333333333333333 0.00651465798045603
TF TF:M10860 Factor: En-1; motif: NYAATTAN 0.0204060569821324 614 12 4 0.333333333333333 0.00651465798045603
TF TF:M00739_1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 0.0204060569821324 1187 112 17 0.151785714285714 0.0143218197135636
TF TF:M11594 Factor: GCMa; motif: ATGNGGGYR 0.0204219643558787 651 30 6 0.2 0.00921658986175115
TF TF:M02067 Factor: ER71; motif: ACCGGAARYN 0.0204219643558787 5930 43 24 0.558139534883721 0.00404721753794266
TF TF:M08289_1 Factor: Fli-1:Max; motif: NCCGGAAACACGTGN; match class: 1 0.0212321244567501 3329 67 23 0.343283582089552 0.00690898167617903
TF TF:M01858_1 Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN; match class: 1 0.0213821464914323 3141 75 24 0.32 0.00764087870105062
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0215418095118993 4149 122 42 0.344262295081967 0.0101229211858279
TF TF:M10014_1 Factor: FXR; motif: NRGGKCANTGRCCNNNNGG; match class: 1 0.0218272374563659 1498 67 14 0.208955223880597 0.00934579439252336
TF TF:M07349_1 Factor: AP-2gamma; motif: NNNNWGCCYNCRGSCN; match class: 1 0.0218272374563659 423 105 9 0.0857142857142857 0.0212765957446809
TF TF:M07290_1 Factor: GLI; motif: NGACCMCCCAN; match class: 1 0.0222736170022656 1902 60 15 0.25 0.00788643533123028
TF TF:M11636 Factor: Sox-12; motif: ACCGAACAATR 0.023057386802414 545 14 4 0.285714285714286 0.0073394495412844
TF TF:M08826_1 Factor: NF-E4; motif: GTGAGGS; match class: 1 0.0246532014776721 4695 123 46 0.373983739837398 0.00979765708200213
TF TF:M10695_1 Factor: HOXA6; motif: RTCRTTAN; match class: 1 0.025162855555374 1493 15 6 0.4 0.00401875418620228
TF TF:M11239_1 Factor: OASIS; motif: TGCCACGTGGCA; match class: 1 0.0255439539446777 99 74 4 0.0540540540540541 0.0404040404040404
TF TF:M01973_1 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC; match class: 1 0.0258158967858295 2398 121 28 0.231404958677686 0.0116763969974979
TF TF:M00446_1 Factor: Spz1; motif: DNNGGRGGGWWNNNN; match class: 1 0.0259106588727521 2858 60 19 0.316666666666667 0.0066480055983205
TF TF:M00179 Factor: ATF2; motif: VGTGACGTMACN 0.0259106588727521 6065 43 24 0.558139534883721 0.00395713107996702
TF TF:M02115_1 Factor: Prx2; motif: TYAWAKTAA; match class: 1 0.0259106588727521 684 12 4 0.333333333333333 0.00584795321637427
TF TF:M11239 Factor: OASIS; motif: TGCCACGTGGCA 0.0259106588727521 100 74 4 0.0540540540540541 0.04
TF TF:M08878 Factor: EGR; motif: CGCCCCCGCNN 0.0259106588727521 7483 121 64 0.528925619834711 0.00855271949752773
TF TF:M00918_1 Factor: E2F; motif: TTTSGCGSG; match class: 1 0.0259106588727521 1255 63 12 0.19047619047619 0.00956175298804781
TF TF:M03971 Factor: ELK1; motif: NACTTCCGSCGGAAGYN 0.0259106588727521 11293 47 38 0.808510638297872 0.00336491631984415
TF TF:M11066_1 Factor: HES-7; motif: GNCACGYGNN; match class: 1 0.0261799931426926 8172 72 44 0.611111111111111 0.00538423886441508
TF TF:M12179 Factor: BTEB3; motif: NRCCACGCCCMCN 0.0261799931426926 1350 112 18 0.160714285714286 0.0133333333333333
TF TF:M00801_1 Factor: CREB; motif: CGTCAN; match class: 1 0.0266312882080142 647 45 7 0.155555555555556 0.0108191653786708
TF TF:M09658_1 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS; match class: 1 0.0266312882080142 2033 122 25 0.204918032786885 0.0122970978848992
TF TF:M12232 Factor: c-Krox; motif: NCGACCACCN 0.0266312882080142 2982 109 30 0.275229357798165 0.0100603621730382
TF TF:M09876_1 Factor: DEC1; motif: NGCACGTGAS; match class: 1 0.0266312882080142 6252 106 50 0.471698113207547 0.00799744081893794
TF TF:M04744_1 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 0.0266747833033934 4889 126 48 0.380952380952381 0.00981795868275721
TF TF:M12181_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0266747833033934 183 112 6 0.0535714285714286 0.0327868852459016
TF TF:M11424_1 Factor: Erm; motif: NNSCGGAWGYN; match class: 1 0.0266747833033934 2835 43 15 0.348837209302326 0.00529100529100529
TF TF:M04743_1 Factor: c-Myc; motif: NSCACGTGGN; match class: 1 0.0271002807483061 3081 74 23 0.310810810810811 0.00746510873093152
TF TF:M10121_1 Factor: ZFX; motif: SNAGGCCNCR; match class: 1 0.0271002807483061 813 111 13 0.117117117117117 0.015990159901599
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0272496212912987 13929 122 102 0.836065573770492 0.00732285160456601
TF TF:M12155 Factor: Sp2; motif: NTWAGTCCCGCCCMCTT 0.0272496212912987 4591 100 38 0.38 0.00827706382051841
TF TF:M10635 Factor: Nkx2-3; motif: GNCGTTRAG 0.0280099454813692 4594 43 20 0.465116279069767 0.0043535045711798
TF TF:M12310 Factor: ZNF597; motif: NGCCGCCATTTTGN 0.0280099454813692 437 87 8 0.0919540229885057 0.0183066361556064
TF TF:M11092 Factor: tfeb; motif: YNCACGTGACN 0.0283190737441331 239 88 6 0.0681818181818182 0.0251046025104603
TF TF:M04439 Factor: SHOX2; motif: NYAATTAN 0.0284653047248909 1323 12 5 0.416666666666667 0.00377928949357521
TF TF:M04390 Factor: LHX9; motif: NYAATTAN 0.0284653047248909 1323 12 5 0.416666666666667 0.00377928949357521
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.0287829359743869 10640 126 86 0.682539682539683 0.00808270676691729
TF TF:M11083 Factor: SREBP-2; motif: ATCAGGTGAT 0.0287841405048309 4490 41 19 0.463414634146341 0.00423162583518931
TF TF:M01154_1 Factor: c-Myc; motif: KACCACGTGSYY; match class: 1 0.0291482567093362 3751 70 25 0.357142857142857 0.00666488936283658
TF TF:M12173_1 Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 0.0292742779858179 4965 122 47 0.385245901639344 0.0094662638469285
TF TF:M00245 Factor: Egr-3; motif: NTGCGTGGGCGK 0.0292742779858179 7313 120 62 0.516666666666667 0.00847805278271571
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.0293908263022415 10055 122 80 0.655737704918033 0.00795624067628046
TF TF:M00799_1 Factor: Myc; motif: CACGTGS; match class: 1 0.0295121533334206 2722 74 21 0.283783783783784 0.00771491550330639
TF TF:M04743 Factor: c-Myc; motif: NSCACGTGGN 0.0295121533334206 4819 106 41 0.386792452830189 0.00850798920937954
TF TF:M06948_1 Factor: Sp2; motif: TGGGCGCGCCCA; match class: 1 0.0297233415792939 6205 126 57 0.452380952380952 0.00918614020950846
TF TF:M00799 Factor: Myc; motif: CACGTGS 0.030035403107434 4988 106 42 0.39622641509434 0.00842020850040096
TF TF:M12156_1 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN; match class: 1 0.030540030832769 1002 93 13 0.139784946236559 0.0129740518962076
TF TF:M00982_1 Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 0.0311903046045155 3518 125 37 0.296 0.0105173393973849
TF TF:M01742 Factor: Zfp206; motif: TGCGCAKGCGC 0.0311903046045155 274 31 4 0.129032258064516 0.0145985401459854
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.0312805622391123 8947 120 72 0.6 0.00804739018665475
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.0312805622391123 10357 126 84 0.666666666666667 0.00811045669595443
TF TF:M01104_1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 0.0320012140705632 5626 121 51 0.421487603305785 0.00906505510131532
TF TF:M11218_1 Factor: CREB1; motif: NRTGAYGCGTN; match class: 1 0.0320361220784569 2438 117 27 0.230769230769231 0.0110746513535685
TF TF:M04702 Factor: REST; motif: TGTCCRTGG 0.0326041564981339 753 124 13 0.104838709677419 0.0172642762284197
TF TF:M07291_1 Factor: GLI2; motif: TGGGTGGTCNS; match class: 1 0.0330241004446645 282 14 3 0.214285714285714 0.0106382978723404
TF TF:M07258_1 Factor: HOXD10; motif: ARGAATAAWAA; match class: 1 0.0334277683114051 56 68 3 0.0441176470588235 0.0535714285714286
TF TF:M07354 Factor: Egr-1; motif: GCGGGGGCGG 0.033470402448764 7801 125 67 0.536 0.00858864248173311
TF TF:M09962_1 Factor: ITF-2; motif: NGCAGSTGKS; match class: 1 0.033470402448764 768 66 9 0.136363636363636 0.01171875
TF TF:M09812_1 Factor: MYC; motif: NNCCACGTGCNN; match class: 1 0.033470402448764 5242 67 30 0.447761194029851 0.00572300648607402
TF TF:M00427 Factor: E2F; motif: TTTSGCGS 0.033470402448764 9485 120 75 0.625 0.00790722192936215
TF TF:M12140 Factor: Egr-1; motif: NNCRCCCMCGCNN 0.033470402448764 5360 121 49 0.40495867768595 0.00914179104477612
TF TF:M08664 Factor: AP-2gamma:Max; motif: NNSCCYNRGGSNNNNCACGTGN 0.033470402448764 2317 59 16 0.271186440677966 0.00690548122572292
TF TF:M08704 Factor: GCMa:HOXA2; motif: RTRNGGGYNTAATNN 0.033470402448764 342 12 3 0.25 0.0087719298245614
TF TF:M04146 Factor: TFAP2A; motif: YGCCCNNRGGCN 0.033470402448764 6552 67 35 0.522388059701492 0.00534188034188034
TF TF:M00916 Factor: CREB; motif: NNTKACGTCANNNS 0.033470402448764 5889 43 23 0.534883720930233 0.00390558668704364
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.033470402448764 10233 126 83 0.658730158730159 0.00811101338805824
TF TF:M00804 Factor: E2A; motif: NCACCTGYYNCNKN 0.0340212908518957 1226 27 7 0.259259259259259 0.00570962479608483
TF TF:M07354_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0342167283421869 3561 125 37 0.296 0.0103903397921932
TF TF:M11042 Factor: HMBOX1; motif: NCTAGTTAN 0.0342167283421869 138 29 3 0.103448275862069 0.0217391304347826
TF TF:M07124 Factor: AML3; motif: KNKNTYTGTGGTTTK 0.0342167283421869 1440 12 5 0.416666666666667 0.00347222222222222
TF TF:M11430_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0342167283421869 4902 39 19 0.487179487179487 0.00387596899224806
TF TF:M00915_1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 0.0342167283421869 4551 57 24 0.421052631578947 0.005273566249176
TF TF:M12188_1 Factor: KLF17; motif: NGMCMCRCCCTN; match class: 1 0.0342167283421869 588 122 11 0.0901639344262295 0.0187074829931973
TF TF:M02036 Factor: WT1; motif: CGCCCCCNCN 0.0346372359546502 9767 119 76 0.638655462184874 0.00778130439234156
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.0347553600503861 4623 122 44 0.360655737704918 0.00951762924507895
TF TF:M09606_1 Factor: nerf; motif: NRRNSCGGAAGNRNNNN; match class: 1 0.034911520046416 1704 126 22 0.174603174603175 0.0129107981220657
TF TF:M07384 Factor: HIF-1alpha; motif: NCACGTNN 0.0353231493958147 1206 111 16 0.144144144144144 0.0132669983416252
TF TF:M11215 Factor: N-Myc; motif: NNCACGTGNN 0.0353231493958147 1206 111 16 0.144144144144144 0.0132669983416252
TF TF:M11245_1 Factor: OASIS; motif: NGCCACGTGGCR; match class: 1 0.0353231493958147 117 35 3 0.0857142857142857 0.0256410256410256
TF TF:M12182_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0353231493958147 206 112 6 0.0535714285714286 0.029126213592233
TF TF:M00737_1 Factor: E2F-1:DP-2; motif: TTTSSCGC; match class: 1 0.0353231493958147 2933 71 21 0.295774647887324 0.00715990453460621
TF TF:M08869 Factor: CLOCKBMAL; motif: NNNWCACGTGGN 0.0357363588392077 1848 88 18 0.204545454545455 0.00974025974025974
TF TF:M01593 Factor: Zfx; motif: SNSCAGGCCKCGSCSS 0.0359069027179169 4163 69 26 0.376811594202899 0.00624549603651213
TF TF:M11079 Factor: SREBP-1; motif: RTCAGGTGAT 0.0366596113180785 3907 41 17 0.414634146341463 0.00435116457640133
TF TF:M02052 Factor: EHF; motif: CSCGGAARTN 0.0370914816390068 10107 49 36 0.73469387755102 0.00356188780053428
TF TF:M00448_1 Factor: Zic1; motif: KGGGTGGTC; match class: 1 0.0373607975562001 4300 41 18 0.439024390243902 0.00418604651162791
TF TF:M11435_1 Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 0.0373607975562001 5745 47 24 0.51063829787234 0.00417754569190601
TF TF:M08868 Factor: ARNTLIKE; motif: NNNSCACGTG 0.0373607975562001 5094 106 42 0.39622641509434 0.00824499411071849
TF TF:M07258 Factor: HOXD10; motif: ARGAATAAWAA 0.0373607975562001 849 12 4 0.333333333333333 0.00471142520612485
TF TF:M04332 Factor: HMBOX1; motif: MYTAGTTAMN 0.0373607975562001 1501 12 5 0.416666666666667 0.0033311125916056
TF TF:M00729 Factor: Cdx-2; motif: ANANTTTTATKRCC 0.0383604555314166 1785 15 6 0.4 0.00336134453781513
TF TF:M00739 Factor: E2F-4:DP-2; motif: TTTCSCGC 0.0383604555314166 5624 48 24 0.5 0.0042674253200569
TF TF:M10426_1 Factor: ctcf; motif: CCRSCAGGGGGCGCN; match class: 1 0.0384605959048421 4369 101 36 0.356435643564356 0.00823987182421607
TF TF:M00032_1 Factor: c-Ets-1(p54); motif: NCMGGAWGYN; match class: 1 0.0394222346093845 2161 115 24 0.208695652173913 0.011105969458584
TF TF:M00119 Factor: Max; motif: NNANCACGTGNTNN 0.0394251103595297 6746 48 27 0.5625 0.00400237177586718
TF TF:M00189_1 Factor: AP-2; motif: MKCCCSCNGGCG; match class: 1 0.0394251103595297 6093 75 36 0.48 0.00590841949778434
TF TF:M00119_1 Factor: Max; motif: NNANCACGTGNTNN; match class: 1 0.0394251103595297 6746 48 27 0.5625 0.00400237177586718
TF TF:M01273_1 Factor: SP4; motif: SCCCCGCCCCS; match class: 1 0.0394251103595297 1016 121 15 0.12396694214876 0.0147637795275591
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.0411022711608001 10023 126 81 0.642857142857143 0.00808141275067345
TF TF:M08205_1 Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 0.0411022711608001 10438 120 80 0.666666666666667 0.00766430350641885
TF TF:M08473_1 Factor: FOXJ2:HOXB13; motif: TTTTATNDGNMAACA; match class: 1 0.0411022711608001 155 29 3 0.103448275862069 0.0193548387096774
TF TF:M09611 Factor: ER81; motif: NNNGRCMGGAAGYRNNNNNNNS 0.0411022711608001 2666 122 29 0.237704918032787 0.0108777194298575
TF TF:M11419 Factor: ER81; motif: NNCCGGAWGYN 0.0411022711608001 5699 122 51 0.418032786885246 0.00894893841024741
TF TF:M08261 Factor: ER71:HOXB13; motif: NNCGGAWGTNGTWAAN 0.0411022711608001 319 31 4 0.129032258064516 0.0125391849529781
TF TF:M08461 Factor: Erm:EVX1; motif: NNCGGAAATKR 0.0411022711608001 3396 32 13 0.40625 0.00382803297997644
TF TF:M07601 Factor: C-Myc; motif: NGCCACGTGNN 0.0411022711608001 5882 67 32 0.477611940298507 0.00544032641958518
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0413559591607062 6807 121 58 0.479338842975207 0.00852064051711473
TF TF:M09812 Factor: MYC; motif: NNCCACGTGCNN 0.0415253214043134 5507 126 51 0.404761904761905 0.00926094062102778
TF TF:M00431 Factor: E2F-1; motif: TTTSGCGS 0.0420863777573432 7257 119 60 0.504201680672269 0.00826787928896238
TF TF:M10115 Factor: LRF; motif: NRGGGKCKY 0.0420863777573432 7623 125 65 0.52 0.00852682670864489
TF TF:M00427_1 Factor: E2F; motif: TTTSGCGS; match class: 1 0.0420863777573432 3831 103 33 0.320388349514563 0.00861393891934221
TF TF:M08537 Factor: ERF:HES-7; motif: NNCACGYGCNNNCCGGAAGT 0.0420863777573432 205 120 6 0.05 0.0292682926829268
TF TF:M04319_1 Factor: ESX1; motif: NNYAATTANN; match class: 1 0.0420863777573432 402 12 3 0.25 0.00746268656716418
TF TF:M08440 Factor: AP-2gamma:E2F-8; motif: NTTCCCGCNNSCCCSMGGC 0.0420863777573432 1200 74 12 0.162162162162162 0.01
TF TF:M09739_1 Factor: ZGPAT; motif: GRGGCWGNGGNG; match class: 1 0.0427202984415908 2740 125 30 0.24 0.0109489051094891
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.0436603714974141 5133 47 22 0.468085106382979 0.00428599259692188
TF TF:M01199_1 Factor: RNF96; motif: BCCCGCRGCC; match class: 1 0.0436603714974141 4322 75 28 0.373333333333333 0.00647848218417399
TF TF:M03867 Factor: c-Myc; motif: CACGTGGC 0.0436603714974141 7391 106 55 0.518867924528302 0.00744148288458937
TF TF:M10530_1 Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1 0.0436603714974141 3780 121 37 0.305785123966942 0.00978835978835979
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.0440039456342391 5198 121 47 0.388429752066116 0.00904193920738746
TF TF:M00726_1 Factor: USF2; motif: CASGYG; match class: 1 0.0440039456342391 5942 67 32 0.477611940298507 0.00538539212386402
TF TF:M00726 Factor: USF2; motif: CASGYG 0.0440039456342391 5942 67 32 0.477611940298507 0.00538539212386402
TF TF:M08950_1 Factor: MAX; motif: CACGTG; match class: 1 0.0440039456342391 5942 67 32 0.477611940298507 0.00538539212386402
TF TF:M08950 Factor: MAX; motif: CACGTG 0.0440039456342391 5942 67 32 0.477611940298507 0.00538539212386402
TF TF:M01837 Factor: FKLF; motif: BGGGNGGVMD 0.0440039456342391 5442 122 49 0.401639344262295 0.00900404263138552
TF TF:M04147_1 Factor: TFAP2A; motif: NGCCYSAGGCN; match class: 1 0.0440039456342391 1962 121 23 0.190082644628099 0.0117227319062181
TF TF:M09876 Factor: DEC1; motif: NGCACGTGAS 0.0440844968851418 8725 67 42 0.626865671641791 0.00481375358166189
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0445781282559371 6260 126 56 0.444444444444444 0.00894568690095847
TF TF:M03990 Factor: GABPA; motif: ACCGGAAGTN 0.0445781282559371 5258 123 48 0.390243902439024 0.00912894636744009
TF TF:M04324 Factor: GBX2; motif: NNYAATTANN 0.0448310861831751 3485 12 7 0.583333333333333 0.00200860832137733
TF TF:M04154_1 Factor: TFAP2C; motif: NGCCTNAGGCN; match class: 1 0.0451499142229968 1496 121 19 0.15702479338843 0.0127005347593583
TF TF:M00446 Factor: Spz1; motif: DNNGGRGGGWWNNNN 0.0451499142229968 8655 47 31 0.659574468085106 0.00358174465626805
TF TF:M08993_1 Factor: ZNF777; motif: GTCCGYCCCGTCSAACAAT; match class: 1 0.0451499142229968 4112 120 39 0.325 0.00948443579766537
TF TF:M02069 Factor: Erm; motif: ACCGGAAGTN 0.0457674191649195 6892 123 59 0.479674796747967 0.00856065002901915
TF TF:M08784 Factor: Sox-17; motif: ACCGAACAAT 0.0457674191649195 799 14 4 0.285714285714286 0.00500625782227785
TF TF:M04059_1 Factor: NRF-1; motif: YGCGCATGCGCN; match class: 1 0.0461018337225964 1033 35 7 0.2 0.00677637947725073
TF TF:M02073_1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 0.0461018337225964 1488 122 19 0.155737704918033 0.0127688172043011
TF TF:M09969 Factor: EKLF; motif: NGGGYGKGGCNNGG 0.0463365156034388 4589 126 44 0.349206349206349 0.00958814556548268
TF TF:M02115 Factor: Prx2; motif: TYAWAKTAA 0.0463365156034388 3528 12 7 0.583333333333333 0.00198412698412698
TF TF:M12313_1 Factor: ZNF460; motif: NNACNCCCCCCNN; match class: 1 0.0469566283224623 2203 60 15 0.25 0.00680889695869269
TF TF:M01034_1 Factor: Ebox; motif: NCACSTGNCN; match class: 1 0.0469983714124271 879 64 9 0.140625 0.0102389078498294
TF TF:M04106_1 Factor: RUNX2; motif: NRACCGCAAACCGCAN; match class: 1 0.0478195507680534 8372 60 37 0.616666666666667 0.00441949354992833
TF TF:M05386_1 Factor: KLF17; motif: NGGGCGG; match class: 1 0.0478849071724132 2513 120 27 0.225 0.0107441305212893
TF TF:M00652 Factor: NRF-1; motif: CGCATGCGCR 0.0478849071724132 1376 42 9 0.214285714285714 0.0065406976744186
TF TF:M05499_1 Factor: LKLF; motif: NGGGCGG; match class: 1 0.0478849071724132 2513 120 27 0.225 0.0107441305212893
TF TF:M04383 Factor: LBX2; motif: CTNRANSTAATTA 0.0478947551756261 8107 10 9 0.9 0.00111015172073517
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0480447347464315 6225 122 54 0.442622950819672 0.00867469879518072
TF TF:M00189 Factor: AP-2; motif: MKCCCSCNGGCG 0.0484369707347565 10621 75 53 0.706666666666667 0.00499011392524244
TF TF:M00121 Factor: USF; motif: NNRYCACGTGRYNN 0.048834193887715 2483 39 12 0.307692307692308 0.00483286347160693
TF TF:M01873_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.048834193887715 2672 125 29 0.232 0.0108532934131737
TF TF:M07415_1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 1 0.048834193887715 2397 126 27 0.214285714285714 0.0112640801001252
TF TF:M00121_1 Factor: USF; motif: NNRYCACGTGRYNN; match class: 1 0.048834193887715 2483 39 12 0.307692307692308 0.00483286347160693
TF TF:M11434_1 Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 0.048834193887715 2935 42 14 0.333333333333333 0.00477001703577513
TF TF:M08885 Factor: HAIRYLIKE; motif: NNNNCANGTG 0.048834193887715 6024 126 54 0.428571428571429 0.00896414342629482
TF TF:M11490 Factor: LBP-1; motif: NRCCGGTNNNNACCGGYN 0.048834193887715 6748 63 33 0.523809523809524 0.00489033787788975
TF TF:M03924_1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 0.048834193887715 3700 121 36 0.297520661157025 0.00972972972972973
TF TF:M00647 Factor: LXR; motif: TGGGGTYACTNGCGGTCA 0.048834193887715 2543 102 24 0.235294117647059 0.00943767204089658
TF TF:M00122 Factor: USF; motif: NNRNCACGTGNYNN 0.048834193887715 2413 35 11 0.314285714285714 0.00455864069622876
TF TF:M11877_1 Factor: pax-2; motif: NCGTCACGCNYSRNYGCNYN; match class: 1 0.048834193887715 5304 117 46 0.393162393162393 0.00867269984917044
TF TF:M08004_1 Factor: SHOX; motif: NTAATTRN; match class: 1 0.048834193887715 194 27 3 0.111111111111111 0.0154639175257732
TF TF:M07428_1 Factor: Six-3; motif: NWBTAATNYYWN; match class: 1 0.048834193887715 596 45 6 0.133333333333333 0.0100671140939597
TF TF:M06948 Factor: Sp2; motif: TGGGCGCGCCCA 0.048834193887715 8864 126 73 0.579365079365079 0.008235559566787
TF TF:M01273 Factor: SP4; motif: SCCCCGCCCCS 0.048834193887715 3296 121 33 0.272727272727273 0.0100121359223301
TF TF:M00122_1 Factor: USF; motif: NNRNCACGTGNYNN; match class: 1 0.048834193887715 2413 35 11 0.314285714285714 0.00455864069622876
TF TF:M00023_1 Factor: HOXA5; motif: TGCNHNCWYCCYCATTAKTGNDCNMNHYCN; match class: 1 0.0489649893007415 450 102 8 0.0784313725490196 0.0177777777777778
TF TF:M10426 Factor: ctcf; motif: CCRSCAGGGGGCGCN 0.0489649893007415 9305 119 72 0.605042016806723 0.0077377753895755
TF TF:M12221 Factor: ZIC1; motif: NRCCCCCYGCTGYGM 0.0489649893007415 169 31 3 0.0967741935483871 0.0177514792899408
TF TF:M00516 Factor: E2F-1; motif: TTTSGCGCGMNR 0.0497204969330939 6904 114 55 0.482456140350877 0.00796639629200463
TF TF:M11448_1 Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 0.0497204969330939 2324 47 13 0.276595744680851 0.00559380378657487
TF TF:M09606 Factor: nerf; motif: NRRNSCGGAAGNRNNNN 0.0497204969330939 6249 101 46 0.455445544554455 0.00736117778844615
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 7.53544032834422e-09 105 12 7 0.583333333333333 0.0666666666666667
WP WP:WP4324 Mitochondrial complex I assembly model OXPHOS system 0.000748192416161233 56 7 3 0.428571428571429 0.0535714285714286
WP WP:WP623 Oxidative phosphorylation 0.000748192416161233 62 7 3 0.428571428571429 0.0483870967741935
WP WP:WP4396 Nonalcoholic fatty liver disease 0.0436701168678338 159 12 3 0.25 0.0188679245283019

pEpiTd20 transcription factor target enrichment of top program genes

TF enrichment of pEpiTd20
Possible regulators of activation of pEpiTd20 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.