pS25 program activity among Stromal cells

Activation of pS25
pS25 gene program activation in Stromal cells.
Gene program activation of pS25 by different cell subtypes
pS25 gene program activation among cells of different subtypes (Stromal cells).

pS25 top program genes

Top genes of pS25 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS25 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS25
pS25 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0022610 biological adhesion 2.14700931652663e-07 1499 113 33 0.292035398230089 0.0220146764509673
GO:BP GO:0007155 cell adhesion 4.42891039535748e-07 1492 113 32 0.283185840707965 0.0214477211796247
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 7.1285211037389e-06 1202 49 17 0.346938775510204 0.0141430948419301
GO:BP GO:0001525 angiogenesis 4.77763646045063e-05 617 49 12 0.244897959183673 0.0194489465153971
GO:BP GO:0009653 anatomical structure morphogenesis 6.28612369654594e-05 2797 69 29 0.420289855072464 0.0103682516982481
GO:BP GO:0035239 tube morphogenesis 6.52251565044428e-05 950 49 14 0.285714285714286 0.0147368421052632
GO:BP GO:0072359 circulatory system development 7.03564436067056e-05 1194 73 19 0.26027397260274 0.0159128978224456
GO:BP GO:0001568 blood vessel development 8.35137069640964e-05 792 69 15 0.217391304347826 0.0189393939393939
GO:BP GO:0048514 blood vessel morphogenesis 9.84418408101903e-05 711 49 12 0.244897959183673 0.0168776371308017
GO:BP GO:0016477 cell migration 0.00010045861292844 1649 85 24 0.282352941176471 0.0145542753183748
GO:BP GO:0001944 vasculature development 0.000110590623758893 830 69 15 0.217391304347826 0.0180722891566265
GO:BP GO:0050878 regulation of body fluid levels 0.000189691957196965 514 85 13 0.152941176470588 0.0252918287937743
GO:BP GO:0098609 cell-cell adhesion 0.0002006100835144 894 77 16 0.207792207792208 0.0178970917225951
GO:BP GO:0035295 tube development 0.000271206693392482 1146 49 14 0.285714285714286 0.012216404886562
GO:BP GO:0051674 localization of cell 0.000403285273809578 1828 85 24 0.282352941176471 0.0131291028446389
GO:BP GO:0048870 cell motility 0.000403285273809578 1828 85 24 0.282352941176471 0.0131291028446389
GO:BP GO:1903238 positive regulation of leukocyte tethering or rolling 0.000663450001624798 8 75 3 0.04 0.375
GO:BP GO:0009611 response to wounding 0.000780433399964619 674 55 11 0.2 0.0163204747774481
GO:BP GO:0042060 wound healing 0.000814315530060914 549 55 10 0.181818181818182 0.0182149362477231
GO:BP GO:0007507 heart development 0.000982344395190812 578 92 13 0.141304347826087 0.0224913494809689
GO:BP GO:0050901 leukocyte tethering or rolling 0.000982344395190812 30 75 4 0.0533333333333333 0.133333333333333
GO:BP GO:0030334 regulation of cell migration 0.0010041683176131 999 81 16 0.197530864197531 0.016016016016016
GO:BP GO:0040011 locomotion 0.001643945623924 2028 69 21 0.304347826086957 0.0103550295857988
GO:BP GO:2000145 regulation of cell motility 0.00195332856962914 1061 81 16 0.197530864197531 0.0150801131008483
GO:BP GO:1903236 regulation of leukocyte tethering or rolling 0.0022699647340757 13 75 3 0.04 0.230769230769231
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.00237756898208202 1001 108 18 0.166666666666667 0.017982017982018
GO:BP GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 0.00237756898208202 277 77 8 0.103896103896104 0.0288808664259928
GO:BP GO:0040012 regulation of locomotion 0.00237756898208202 1104 81 16 0.197530864197531 0.0144927536231884
GO:BP GO:0010543 regulation of platelet activation 0.00237756898208202 36 85 4 0.0470588235294118 0.111111111111111
GO:BP GO:0048878 chemical homeostasis 0.00237756898208202 1229 15 7 0.466666666666667 0.00569568755085435
GO:BP GO:0050900 leukocyte migration 0.00237756898208202 511 85 11 0.129411764705882 0.0215264187866928
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.00237756898208202 1001 108 18 0.166666666666667 0.017982017982018
GO:BP GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 0.00237756898208202 44 69 4 0.0579710144927536 0.0909090909090909
GO:BP GO:0006928 movement of cell or subcellular component 0.00243985226856518 2311 69 22 0.318840579710145 0.00951968844655993
GO:BP GO:0031581 hemidesmosome assembly 0.00246572751135437 12 94 3 0.0319148936170213 0.25
GO:BP GO:0045765 regulation of angiogenesis 0.00258161001936163 358 81 9 0.111111111111111 0.0251396648044693
GO:BP GO:1901342 regulation of vasculature development 0.00275396123076082 364 81 9 0.111111111111111 0.0247252747252747
GO:BP GO:0032502 developmental process 0.00275396123076082 6628 69 42 0.608695652173913 0.00633675316837658
GO:BP GO:0007596 blood coagulation 0.00275396123076082 347 85 9 0.105882352941176 0.0259365994236311
GO:BP GO:0051270 regulation of cellular component movement 0.00285110665292849 1141 81 16 0.197530864197531 0.014022787028922
GO:BP GO:0007599 hemostasis 0.00285953350968888 351 85 9 0.105882352941176 0.0256410256410256
GO:BP GO:0032102 negative regulation of response to external stimulus 0.00285953350968888 406 92 10 0.108695652173913 0.0246305418719212
GO:BP GO:0050817 coagulation 0.00285953350968888 354 85 9 0.105882352941176 0.0254237288135593
GO:BP GO:0030198 extracellular matrix organization 0.00285953350968888 401 113 11 0.0973451327433628 0.027431421446384
GO:BP GO:0043062 extracellular structure organization 0.00285975724588509 402 113 11 0.0973451327433628 0.027363184079602
GO:BP GO:0016192 vesicle-mediated transport 0.002863786646075 2180 129 32 0.248062015503876 0.0146788990825688
GO:BP GO:0045229 external encapsulating structure organization 0.002863786646075 404 113 11 0.0973451327433628 0.0272277227722772
GO:BP GO:0097553 calcium ion transmembrane import into cytosol 0.0033455771080986 145 51 5 0.0980392156862745 0.0344827586206897
GO:BP GO:0002274 myeloid leukocyte activation 0.00344572073373418 667 125 15 0.12 0.0224887556221889
GO:BP GO:0032879 regulation of localization 0.00345578086628086 2872 84 28 0.333333333333333 0.00974930362116992
GO:BP GO:0001775 cell activation 0.00454955345564237 1495 125 24 0.192 0.0160535117056856
GO:BP GO:0048856 anatomical structure development 0.00470031050795748 6106 69 39 0.565217391304348 0.00638716017032427
GO:BP GO:0061756 leukocyte adhesion to vascular endothelial cell 0.00478442335481328 56 75 4 0.0533333333333333 0.0714285714285714
GO:BP GO:0010544 negative regulation of platelet activation 0.00508207600854823 19 85 3 0.0352941176470588 0.157894736842105
GO:BP GO:0045055 regulated exocytosis 0.00535945227485397 785 125 16 0.128 0.0203821656050955
GO:BP GO:0060402 calcium ion transport into cytosol 0.00535945227485397 165 51 5 0.0980392156862745 0.0303030303030303
GO:BP GO:0030168 platelet activation 0.00549559270644473 160 85 6 0.0705882352941176 0.0375
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.00549559270644473 547 125 13 0.104 0.0237659963436929
GO:BP GO:0030155 regulation of cell adhesion 0.00550585249252817 748 37 8 0.216216216216216 0.0106951871657754
GO:BP GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell 0.00568491107328421 23 75 3 0.04 0.130434782608696
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00621095458060595 485 125 12 0.096 0.0247422680412371
GO:BP GO:0007229 integrin-mediated signaling pathway 0.00621095458060595 111 80 5 0.0625 0.045045045045045
GO:BP GO:0048731 system development 0.00621095458060595 5052 69 34 0.492753623188406 0.00673000791765637
GO:BP GO:0043312 neutrophil degranulation 0.00621095458060595 482 125 12 0.096 0.024896265560166
GO:BP GO:0043085 positive regulation of catalytic activity 0.00635047722858484 1418 112 21 0.1875 0.0148095909732017
GO:BP GO:0006954 inflammatory response 0.00665715382768254 794 13 5 0.384615384615385 0.00629722921914358
GO:BP GO:0060401 cytosolic calcium ion transport 0.00701946746776236 186 51 5 0.0980392156862745 0.0268817204301075
GO:BP GO:0002446 neutrophil mediated immunity 0.00701946746776236 497 125 12 0.096 0.0241448692152917
GO:BP GO:0042119 neutrophil activation 0.00701946746776236 498 125 12 0.096 0.0240963855421687
GO:BP GO:0036230 granulocyte activation 0.00749804637185514 504 125 12 0.096 0.0238095238095238
GO:BP GO:1904018 positive regulation of vasculature development 0.00749804637185514 187 81 6 0.0740740740740741 0.0320855614973262
GO:BP GO:0045766 positive regulation of angiogenesis 0.00749804637185514 187 81 6 0.0740740740740741 0.0320855614973262
GO:BP GO:0045123 cellular extravasation 0.00776826301032912 70 75 4 0.0533333333333333 0.0571428571428571
GO:BP GO:0002376 immune system process 0.0079171204156776 3278 128 40 0.3125 0.012202562538133
GO:BP GO:0010522 regulation of calcium ion transport into cytosol 0.00809319174540269 106 51 4 0.0784313725490196 0.0377358490566038
GO:BP GO:0051179 localization 0.00811318634319653 6901 77 45 0.584415584415584 0.00652079408781336
GO:BP GO:0032501 multicellular organismal process 0.00863146226525322 7946 56 38 0.678571428571429 0.00478228039265039
GO:BP GO:0003170 heart valve development 0.00972535024756882 63 92 4 0.0434782608695652 0.0634920634920635
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.00972535024756882 325 51 6 0.117647058823529 0.0184615384615385
GO:BP GO:0043542 endothelial cell migration 0.00994887800245636 290 81 7 0.0864197530864197 0.0241379310344828
GO:BP GO:0034446 substrate adhesion-dependent cell spreading 0.00994887800245636 109 54 4 0.0740740740740741 0.036697247706422
GO:BP GO:0031589 cell-substrate adhesion 0.00994887800245636 367 130 10 0.0769230769230769 0.0272479564032698
GO:BP GO:0043299 leukocyte degranulation 0.00994887800245636 535 125 12 0.096 0.0224299065420561
GO:BP GO:0001667 ameboidal-type cell migration 0.0104213657110541 494 81 9 0.111111111111111 0.0182186234817814
GO:BP GO:0034329 cell junction assembly 0.011282086224626 438 112 10 0.0892857142857143 0.0228310502283105
GO:BP GO:0051209 release of sequestered calcium ion into cytosol 0.0113962589749035 123 51 4 0.0784313725490196 0.032520325203252
GO:BP GO:0007044 cell-substrate junction assembly 0.0115450331422417 101 112 5 0.0446428571428571 0.0495049504950495
GO:BP GO:0051283 negative regulation of sequestering of calcium ion 0.0115450331422417 124 51 4 0.0784313725490196 0.032258064516129
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.011594721666227 551 125 12 0.096 0.0217785843920145
GO:BP GO:0001885 endothelial cell development 0.011594721666227 69 92 4 0.0434782608695652 0.0579710144927536
GO:BP GO:0051282 regulation of sequestering of calcium ion 0.011594721666227 126 51 4 0.0784313725490196 0.0317460317460317
GO:BP GO:0023052 signaling 0.011594721666227 6810 88 49 0.556818181818182 0.00719530102790015
GO:BP GO:0002366 leukocyte activation involved in immune response 0.011594721666227 717 125 14 0.112 0.0195258019525802
GO:BP GO:0045446 endothelial cell differentiation 0.0116194118378423 125 92 5 0.0543478260869565 0.04
GO:BP GO:0002263 cell activation involved in immune response 0.0118681359351923 721 125 14 0.112 0.0194174757281553
GO:BP GO:0006887 exocytosis 0.0124636444341488 904 125 16 0.128 0.0176991150442478
GO:BP GO:0061045 negative regulation of wound healing 0.0124636444341488 78 85 4 0.0470588235294118 0.0512820512820513
GO:BP GO:0051208 sequestering of calcium ion 0.0124636444341488 130 51 4 0.0784313725490196 0.0307692307692308
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.0125051617505372 360 51 6 0.117647058823529 0.0166666666666667
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0125524339747274 1042 69 12 0.173913043478261 0.0115163147792706
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.0125524339747274 1645 92 19 0.206521739130435 0.0115501519756839
GO:BP GO:0019220 regulation of phosphate metabolic process 0.0125524339747274 1645 92 19 0.206521739130435 0.0115501519756839
GO:BP GO:0003018 vascular process in circulatory system 0.0125524339747274 256 99 7 0.0707070707070707 0.02734375
GO:BP GO:0150115 cell-substrate junction organization 0.0126588994394929 107 112 5 0.0446428571428571 0.0467289719626168
GO:BP GO:0042592 homeostatic process 0.0126840061606143 1981 15 7 0.466666666666667 0.00353356890459364
GO:BP GO:0035336 long-chain fatty-acyl-CoA metabolic process 0.0132552555533817 25 120 3 0.025 0.12
GO:BP GO:0055065 metal ion homeostasis 0.0153564997785978 667 12 4 0.333333333333333 0.00599700149925037
GO:BP GO:0050727 regulation of inflammatory response 0.0153564997785978 381 92 8 0.0869565217391304 0.020997375328084
GO:BP GO:0051649 establishment of localization in cell 0.0154983784862529 2813 75 23 0.306666666666667 0.00817632420902951
GO:BP GO:0003176 aortic valve development 0.0170509752957022 36 92 3 0.0326086956521739 0.0833333333333333
GO:BP GO:0003158 endothelium development 0.0171084507879315 143 92 5 0.0543478260869565 0.034965034965035
GO:BP GO:0030036 actin cytoskeleton organization 0.0175692616882394 709 135 14 0.103703703703704 0.0197461212976023
GO:BP GO:0007275 multicellular organism development 0.0183438542989368 5613 81 39 0.481481481481481 0.00694815606627472
GO:BP GO:0010863 positive regulation of phospholipase C activity 0.0185752565670461 46 75 3 0.04 0.0652173913043478
GO:BP GO:0003007 heart morphogenesis 0.0185752565670461 251 81 6 0.0740740740740741 0.0239043824701195
GO:BP GO:0006952 defense response 0.0187702804097677 1818 13 6 0.461538461538462 0.0033003300330033
GO:BP GO:0030335 positive regulation of cell migration 0.0187702804097677 567 81 9 0.111111111111111 0.0158730158730159
GO:BP GO:0007154 cell communication 0.0187702804097677 6829 88 48 0.545454545454545 0.0070288475618685
GO:BP GO:1903035 negative regulation of response to wounding 0.0188058671631678 93 85 4 0.0470588235294118 0.043010752688172
GO:BP GO:1903169 regulation of calcium ion transmembrane transport 0.0193322484988461 158 51 4 0.0784313725490196 0.0253164556962025
GO:BP GO:0030029 actin filament-based process 0.0193580048938334 808 135 15 0.111111111111111 0.0185643564356436
GO:BP GO:1900274 regulation of phospholipase C activity 0.0194515248420815 48 75 3 0.04 0.0625
GO:BP GO:0045776 negative regulation of blood pressure 0.0200081461978819 45 81 3 0.037037037037037 0.0666666666666667
GO:BP GO:0055080 cation homeostasis 0.0200988143665466 750 51 8 0.156862745098039 0.0106666666666667
GO:BP GO:0044093 positive regulation of molecular function 0.0202465461923616 1771 112 22 0.196428571428571 0.0124223602484472
GO:BP GO:0098771 inorganic ion homeostasis 0.0208113245044629 761 12 4 0.333333333333333 0.00525624178712221
GO:BP GO:1905314 semi-lunar valve development 0.0208113245044629 41 92 3 0.0326086956521739 0.0731707317073171
GO:BP GO:1903034 regulation of response to wounding 0.0208113245044629 169 85 5 0.0588235294117647 0.029585798816568
GO:BP GO:0051279 regulation of release of sequestered calcium ion into cytosol 0.0208113245044629 85 98 4 0.0408163265306122 0.0470588235294118
GO:BP GO:0042327 positive regulation of phosphorylation 0.0208113245044629 927 108 14 0.12962962962963 0.0151024811218986
GO:BP GO:0009887 animal organ morphogenesis 0.020904112385792 1073 64 11 0.171875 0.0102516309412861
GO:BP GO:2000147 positive regulation of cell motility 0.021365112106752 591 81 9 0.111111111111111 0.0152284263959391
GO:BP GO:0032496 response to lipopolysaccharide 0.0214692296866859 338 88 7 0.0795454545454545 0.0207100591715976
GO:BP GO:0010631 epithelial cell migration 0.0218359110627292 370 81 7 0.0864197530864197 0.0189189189189189
GO:BP GO:0009617 response to bacterium 0.0218427261804393 743 92 11 0.119565217391304 0.0148048452220727
GO:BP GO:0090132 epithelium migration 0.0225020606987479 373 81 7 0.0864197530864197 0.0187667560321716
GO:BP GO:0019932 second-messenger-mediated signaling 0.0231492504284069 327 13 3 0.230769230769231 0.00917431192660551
GO:BP GO:0050801 ion homeostasis 0.0231492504284069 808 12 4 0.333333333333333 0.00495049504950495
GO:BP GO:0051272 positive regulation of cellular component movement 0.0233111650934881 604 81 9 0.111111111111111 0.0149006622516556
GO:BP GO:0040017 positive regulation of locomotion 0.0233238466924465 606 81 9 0.111111111111111 0.0148514851485149
GO:BP GO:0090130 tissue migration 0.0233238466924465 379 81 7 0.0864197530864197 0.0184696569920844
GO:BP GO:0007160 cell-matrix adhesion 0.0233238466924465 235 130 7 0.0538461538461538 0.0297872340425532
GO:BP GO:0030195 negative regulation of blood coagulation 0.0248684721709358 50 85 3 0.0352941176470588 0.06
GO:BP GO:1900047 negative regulation of hemostasis 0.0258482465599612 51 85 3 0.0352941176470588 0.0588235294117647
GO:BP GO:0000902 cell morphogenesis 0.0258482465599612 1037 69 11 0.159420289855072 0.0106075216972035
GO:BP GO:0006874 cellular calcium ion homeostasis 0.0258566741632284 460 51 6 0.117647058823529 0.0130434782608696
GO:BP GO:0050728 negative regulation of inflammatory response 0.0259833009804736 171 92 5 0.0543478260869565 0.0292397660818713
GO:BP GO:0003179 heart valve morphogenesis 0.0260123170737309 54 81 3 0.037037037037037 0.0555555555555556
GO:BP GO:1901700 response to oxygen-containing compound 0.0260123170737309 1739 15 6 0.4 0.00345025876940771
GO:BP GO:0048583 regulation of response to stimulus 0.0260197551216788 4278 117 42 0.358974358974359 0.00981767180925666
GO:BP GO:0045785 positive regulation of cell adhesion 0.0261751925996403 437 37 5 0.135135135135135 0.011441647597254
GO:BP GO:0002237 response to molecule of bacterial origin 0.0264205867246732 361 88 7 0.0795454545454545 0.0193905817174515
GO:BP GO:0045321 leukocyte activation 0.0269893349212309 1332 125 19 0.152 0.0142642642642643
GO:BP GO:0018212 peptidyl-tyrosine modification 0.0273064612967817 388 106 8 0.0754716981132075 0.0206185567010309
GO:BP GO:0070588 calcium ion transmembrane transport 0.0273184436529286 320 51 5 0.0980392156862745 0.015625
GO:BP GO:0055074 calcium ion homeostasis 0.0273184436529286 472 51 6 0.117647058823529 0.0127118644067797
GO:BP GO:0061028 establishment of endothelial barrier 0.0279734654106166 50 92 3 0.0326086956521739 0.06
GO:BP GO:0002252 immune effector process 0.0279734654106166 1309 128 19 0.1484375 0.014514896867838
GO:BP GO:0098657 import into cell 0.0279734654106166 235 137 7 0.0510948905109489 0.0297872340425532
GO:BP GO:0003013 circulatory system process 0.0280567377797899 637 81 9 0.111111111111111 0.0141287284144427
GO:BP GO:0065008 regulation of biological quality 0.0280567377797899 4131 15 9 0.6 0.00217864923747277
GO:BP GO:0010518 positive regulation of phospholipase activity 0.0283326983050342 62 75 3 0.04 0.0483870967741935
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.0284806490260996 223 108 6 0.0555555555555556 0.0269058295964126
GO:BP GO:0002040 sprouting angiogenesis 0.0287791082029143 204 49 4 0.0816326530612245 0.0196078431372549
GO:BP GO:0006810 transport 0.0289801031320767 5224 17 11 0.647058823529412 0.00210566615620214
GO:BP GO:0055082 cellular chemical homeostasis 0.0289801031320767 841 51 8 0.156862745098039 0.00951248513674197
GO:BP GO:0050819 negative regulation of coagulation 0.0293556028645922 56 85 3 0.0352941176470588 0.0535714285714286
GO:BP GO:0007165 signal transduction 0.029760928174741 6309 88 44 0.5 0.00697416389285148
GO:BP GO:0051050 positive regulation of transport 0.029760928174741 923 12 4 0.333333333333333 0.00433369447453954
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.029760928174741 3087 92 27 0.293478260869565 0.0087463556851312
GO:BP GO:0043112 receptor metabolic process 0.029760928174741 174 28 3 0.107142857142857 0.0172413793103448
GO:BP GO:0060341 regulation of cellular localization 0.0298444281790682 851 51 8 0.156862745098039 0.00940070505287897
GO:BP GO:0032101 regulation of response to external stimulus 0.0298863140537466 1051 92 13 0.141304347826087 0.0123691722169363
GO:BP GO:0050729 positive regulation of inflammatory response 0.0308657233134216 142 35 3 0.0857142857142857 0.0211267605633803
GO:BP GO:1901655 cellular response to ketone 0.0308657233134216 97 51 3 0.0588235294117647 0.0309278350515464
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.0311441423984218 159 108 5 0.0462962962962963 0.0314465408805031
GO:BP GO:0030003 cellular cation homeostasis 0.0311441423984218 673 51 7 0.137254901960784 0.0104011887072808
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0311441423984218 1842 20 7 0.35 0.00380021715526602
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.0311441423984218 497 51 6 0.117647058823529 0.0120724346076459
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0312728537658329 2255 95 22 0.231578947368421 0.00975609756097561
GO:BP GO:0006793 phosphorus metabolic process 0.0313131371191621 3114 92 27 0.293478260869565 0.00867052023121387
GO:BP GO:0035337 fatty-acyl-CoA metabolic process 0.0313374858996856 42 120 3 0.025 0.0714285714285714
GO:BP GO:0061383 trabecula morphogenesis 0.0321106722652507 44 116 3 0.0258620689655172 0.0681818181818182
GO:BP GO:0035556 intracellular signal transduction 0.0321106722652507 2772 128 32 0.25 0.0115440115440115
GO:BP GO:0050790 regulation of catalytic activity 0.0322326767358433 2545 101 25 0.247524752475248 0.00982318271119843
GO:BP GO:0051234 establishment of localization 0.0323245193397301 5372 17 11 0.647058823529412 0.00204765450483991
GO:BP GO:1990778 protein localization to cell periphery 0.0323245193397301 338 129 8 0.062015503875969 0.0236686390532544
GO:BP GO:0016525 negative regulation of angiogenesis 0.0323245193397301 161 109 5 0.0458715596330275 0.031055900621118
GO:BP GO:0002443 leukocyte mediated immunity 0.0323245193397301 877 125 14 0.112 0.015963511972634
GO:BP GO:0006873 cellular ion homeostasis 0.0327041318704545 687 51 7 0.137254901960784 0.0101892285298399
GO:BP GO:2000181 negative regulation of blood vessel morphogenesis 0.0335575098643276 163 109 5 0.0458715596330275 0.0306748466257669
GO:BP GO:0034097 response to cytokine 0.0339682396436417 1226 131 18 0.137404580152672 0.0146818923327896
GO:BP GO:1901343 negative regulation of vasculature development 0.0339682396436417 164 109 5 0.0458715596330275 0.0304878048780488
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.0339682396436417 516 51 6 0.117647058823529 0.0116279069767442
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.0339682396436417 215 51 4 0.0784313725490196 0.0186046511627907
GO:BP GO:0033993 response to lipid 0.0347282675814777 918 13 4 0.307692307692308 0.00435729847494553
GO:BP GO:0051641 cellular localization 0.0352193134552432 3541 75 25 0.333333333333333 0.00706015249929398
GO:BP GO:1904062 regulation of cation transmembrane transport 0.0352193134552432 360 51 5 0.0980392156862745 0.0138888888888889
GO:BP GO:0034767 positive regulation of ion transmembrane transport 0.0352989476320213 217 84 5 0.0595238095238095 0.0230414746543779
GO:BP GO:0034764 positive regulation of transmembrane transport 0.0352989476320213 217 84 5 0.0595238095238095 0.0230414746543779
GO:BP GO:0033674 positive regulation of kinase activity 0.0354570791584181 608 108 10 0.0925925925925926 0.0164473684210526
GO:BP GO:0010517 regulation of phospholipase activity 0.035577864272943 73 75 3 0.04 0.0410958904109589
GO:BP GO:0051651 maintenance of location in cell 0.0361128226322873 223 51 4 0.0784313725490196 0.0179372197309417
GO:BP GO:0060193 positive regulation of lipase activity 0.0372834159020435 75 75 3 0.04 0.04
GO:BP GO:0016032 viral process 0.0372956349570451 942 95 12 0.126315789473684 0.0127388535031847
GO:BP GO:0061041 regulation of wound healing 0.0383344235599135 136 85 4 0.0470588235294118 0.0294117647058824
GO:BP GO:0048871 multicellular organismal homeostasis 0.0390367305564168 530 126 10 0.0793650793650794 0.0188679245283019
GO:BP GO:0046683 response to organophosphorus 0.0390884634076126 137 85 4 0.0470588235294118 0.0291970802919708
GO:BP GO:0006875 cellular metal ion homeostasis 0.0394262689344653 593 132 11 0.0833333333333333 0.0185497470489039
GO:BP GO:0030193 regulation of blood coagulation 0.0394262689344653 68 85 3 0.0352941176470588 0.0441176470588235
GO:BP GO:1900046 regulation of hemostasis 0.0396659659669422 69 85 3 0.0352941176470588 0.0434782608695652
GO:BP GO:0046718 viral entry into host cell 0.0399494910595559 141 42 3 0.0714285714285714 0.0212765957446809
GO:BP GO:0006950 response to stress 0.0401011479110221 4170 59 23 0.389830508474576 0.00551558752997602
GO:BP GO:0000165 MAPK cascade 0.0401011479110221 935 51 8 0.156862745098039 0.00855614973262032
GO:BP GO:0034765 regulation of ion transmembrane transport 0.0401011479110221 583 98 9 0.0918367346938776 0.0154373927958834
GO:BP GO:0072522 purine-containing compound biosynthetic process 0.0403243893120796 213 91 5 0.0549450549450549 0.0234741784037559
GO:BP GO:0042325 regulation of phosphorylation 0.0403243893120796 1431 73 13 0.178082191780822 0.00908455625436757
GO:BP GO:0022612 gland morphogenesis 0.0403773864028554 120 50 3 0.06 0.025
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.0408448769840557 375 99 7 0.0707070707070707 0.0186666666666667
GO:BP GO:0034762 regulation of transmembrane transport 0.0411970749172329 588 98 9 0.0918367346938776 0.0153061224489796
GO:BP GO:0042127 regulation of cell population proliferation 0.0419594704816963 1774 88 17 0.193181818181818 0.00958286358511838
GO:BP GO:0000904 cell morphogenesis involved in differentiation 0.0419594704816963 749 64 8 0.125 0.0106809078771696
GO:BP GO:0030316 osteoclast differentiation 0.042351589391504 98 126 4 0.0317460317460317 0.0408163265306122
GO:BP GO:0034330 cell junction organization 0.0429808335441702 722 112 11 0.0982142857142857 0.0152354570637119
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.0429808335441702 185 108 5 0.0462962962962963 0.027027027027027
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0429808335441702 1564 108 18 0.166666666666667 0.0115089514066496
GO:BP GO:0002064 epithelial cell development 0.0429808335441702 218 92 5 0.0543478260869565 0.0229357798165138
GO:BP GO:0048513 animal organ development 0.0429808335441702 3672 67 23 0.343283582089552 0.0062636165577342
GO:BP GO:0140253 cell-cell fusion 0.0439597904525586 55 116 3 0.0258620689655172 0.0545454545454545
GO:BP GO:0000768 syncytium formation by plasma membrane fusion 0.0439597904525586 55 116 3 0.0258620689655172 0.0545454545454545
GO:BP GO:0050818 regulation of coagulation 0.0439597904525586 75 85 3 0.0352941176470588 0.04
GO:BP GO:0009605 response to external stimulus 0.0441050732711303 2944 92 25 0.271739130434783 0.00849184782608696
GO:BP GO:0061025 membrane fusion 0.0441050732711303 179 71 4 0.0563380281690141 0.0223463687150838
GO:BP GO:0044409 entry into host 0.0445850363751724 154 42 3 0.0714285714285714 0.0194805194805195
GO:BP GO:0060976 coronary vasculature development 0.0451012511211921 48 136 3 0.0220588235294118 0.0625
GO:BP GO:0014074 response to purine-containing compound 0.0454739569698986 152 85 4 0.0470588235294118 0.0263157894736842
GO:BP GO:0032940 secretion by cell 0.0454739569698986 1364 125 18 0.144 0.0131964809384164
GO:BP GO:0019725 cellular homeostasis 0.0454739569698986 981 51 8 0.156862745098039 0.00815494393476045
GO:BP GO:0006949 syncytium formation 0.0454739569698986 57 116 3 0.0258620689655172 0.0526315789473684
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0454739569698986 385 101 7 0.0693069306930693 0.0181818181818182
GO:BP GO:0051924 regulation of calcium ion transport 0.0468157294685256 259 51 4 0.0784313725490196 0.0154440154440154
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0468157294685256 1001 95 12 0.126315789473684 0.011988011988012
GO:BP GO:2000026 regulation of multicellular organismal development 0.0468509969295995 1447 92 15 0.16304347826087 0.0103662750518314
GO:BP GO:0051707 response to other organism 0.0472993258467426 1592 92 16 0.173913043478261 0.0100502512562814
GO:BP GO:0043207 response to external biotic stimulus 0.0474969401887657 1594 92 16 0.173913043478261 0.0100376411543287
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0479119227558934 3210 117 32 0.273504273504274 0.00996884735202492
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.0483809047913646 1477 108 17 0.157407407407407 0.011509817197021
GO:BP GO:1902414 protein localization to cell junction 0.0494397327534762 113 119 4 0.0336134453781513 0.0353982300884956
GO:CC GO:0071944 cell periphery 2.04849849582229e-07 6169 56 41 0.732142857142857 0.00664613389528287
GO:CC GO:0005886 plasma membrane 6.38053350688892e-06 5681 99 56 0.565656565656566 0.00985741946840345
GO:CC GO:0031226 intrinsic component of plasma membrane 1.85893864316788e-05 1726 99 27 0.272727272727273 0.0156431054461182
GO:CC GO:0005887 integral component of plasma membrane 7.91751607016908e-05 1645 99 25 0.252525252525253 0.0151975683890578
GO:CC GO:0031982 vesicle 0.000112497566696588 4055 61 30 0.491803278688525 0.00739827373612824
GO:CC GO:0030141 secretory granule 0.000316833218705172 851 129 19 0.147286821705426 0.0223266745005875
GO:CC GO:0005615 extracellular space 0.000316833218705172 3594 103 39 0.378640776699029 0.0108514190317195
GO:CC GO:0070062 extracellular exosome 0.000422747477070637 2176 61 20 0.327868852459016 0.00919117647058824
GO:CC GO:0070161 anchoring junction 0.000507775593638816 836 94 15 0.159574468085106 0.0179425837320574
GO:CC GO:0043230 extracellular organelle 0.000507775593638816 2263 61 20 0.327868852459016 0.00883782589482987
GO:CC GO:1903561 extracellular vesicle 0.000507775593638816 2261 61 20 0.327868852459016 0.00884564352056612
GO:CC GO:0098588 bounding membrane of organelle 0.000507775593638816 2158 128 32 0.25 0.0148285449490269
GO:CC GO:0099503 secretory vesicle 0.000520805138699557 1020 129 20 0.155038759689922 0.0196078431372549
GO:CC GO:0031224 intrinsic component of membrane 0.000520805138699557 5868 17 14 0.823529411764706 0.00238582140422631
GO:CC GO:0005576 extracellular region 0.000551888605028095 4567 103 44 0.427184466019417 0.00963433326034596
GO:CC GO:0097708 intracellular vesicle 0.000551888605028095 2428 129 34 0.263565891472868 0.014003294892916
GO:CC GO:0030667 secretory granule membrane 0.000551888605028095 303 119 10 0.0840336134453782 0.033003300330033
GO:CC GO:0031410 cytoplasmic vesicle 0.000551888605028095 2424 129 34 0.263565891472868 0.014026402640264
GO:CC GO:0009986 cell surface 0.000554830687564283 899 92 15 0.16304347826087 0.0166852057842047
GO:CC GO:0005925 focal adhesion 0.00129116704025829 420 62 8 0.129032258064516 0.019047619047619
GO:CC GO:0030054 cell junction 0.00131168163305885 2105 77 21 0.272727272727273 0.00997624703087886
GO:CC GO:0030055 cell-substrate junction 0.00131750175459449 427 62 8 0.129032258064516 0.0187353629976581
GO:CC GO:0016020 membrane 0.00131979380312618 9838 133 91 0.684210526315789 0.00924984752998577
GO:CC GO:0005911 cell-cell junction 0.00232601295940958 494 110 11 0.1 0.0222672064777328
GO:CC GO:0005912 adherens junction 0.00232601295940958 173 87 6 0.0689655172413793 0.0346820809248555
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.0024453236951617 779 123 15 0.121951219512195 0.0192554557124519
GO:CC GO:0012506 vesicle membrane 0.00314118374672391 800 123 15 0.121951219512195 0.01875
GO:CC GO:0012505 endomembrane system 0.00342512988594039 4640 133 51 0.383458646616541 0.0109913793103448
GO:CC GO:0000323 lytic vacuole 0.00437575065972273 712 129 14 0.108527131782946 0.0196629213483146
GO:CC GO:0005764 lysosome 0.00437575065972273 712 129 14 0.108527131782946 0.0196629213483146
GO:CC GO:0005773 vacuole 0.00479970425796095 810 129 15 0.116279069767442 0.0185185185185185
GO:CC GO:0016021 integral component of membrane 0.00778574744276423 5711 17 12 0.705882352941177 0.00210120819471196
GO:CC GO:0045178 basal part of cell 0.00795057093980334 265 51 5 0.0980392156862745 0.0188679245283019
GO:CC GO:0098858 actin-based cell projection 0.00801831096115819 220 62 5 0.0806451612903226 0.0227272727272727
GO:CC GO:0043235 receptor complex 0.00942228432759936 522 92 9 0.0978260869565217 0.0172413793103448
GO:CC GO:0045121 membrane raft 0.00942228432759936 335 115 8 0.0695652173913043 0.0238805970149254
GO:CC GO:0045177 apical part of cell 0.00942228432759936 431 51 6 0.117647058823529 0.0139211136890951
GO:CC GO:0098857 membrane microdomain 0.00942228432759936 335 115 8 0.0695652173913043 0.0238805970149254
GO:CC GO:0016528 sarcoplasm 0.00942228432759936 79 46 3 0.0652173913043478 0.0379746835443038
GO:CC GO:0005902 microvillus 0.0155238555253527 91 50 3 0.06 0.032967032967033
GO:CC GO:0055037 recycling endosome 0.0155448992161931 188 129 6 0.0465116279069767 0.0319148936170213
GO:CC GO:0098590 plasma membrane region 0.0157412307504419 1240 119 17 0.142857142857143 0.0137096774193548
GO:CC GO:0016324 apical plasma membrane 0.0211497890295363 361 51 5 0.0980392156862745 0.0138504155124654
GO:CC GO:0031090 organelle membrane 0.0211497890295363 3612 133 39 0.293233082706767 0.010797342192691
GO:CC GO:0016323 basolateral plasma membrane 0.0215274638336356 222 51 4 0.0784313725490196 0.018018018018018
GO:CC GO:0042582 azurophil granule 0.0233795704334177 154 125 5 0.04 0.0324675324675325
GO:CC GO:0005766 primary lysosome 0.0233795704334177 154 125 5 0.04 0.0324675324675325
GO:CC GO:0070820 tertiary granule 0.0237459455046019 163 119 5 0.0420168067226891 0.0306748466257669
GO:CC GO:0009925 basal plasma membrane 0.0268239680175137 247 51 4 0.0784313725490196 0.0161943319838057
GO:CC GO:0005901 caveola 0.0309288385220472 83 81 3 0.037037037037037 0.036144578313253
GO:CC GO:0048471 perinuclear region of cytoplasm 0.03212723308132 735 56 7 0.125 0.00952380952380952
GO:CC GO:0030312 external encapsulating structure 0.0349010650018911 563 113 9 0.079646017699115 0.0159857904085258
GO:CC GO:0031012 extracellular matrix 0.0349010650018911 562 113 9 0.079646017699115 0.0160142348754448
GO:CC GO:0098862 cluster of actin-based cell projections 0.0360516248808342 162 46 3 0.0652173913043478 0.0185185185185185
GO:CC GO:0031225 anchored component of membrane 0.0370089597360391 174 132 5 0.0378787878787879 0.028735632183908
GO:CC GO:0098978 glutamatergic synapse 0.0379481865239486 349 123 7 0.0569105691056911 0.0200573065902579
GO:CC GO:0005884 actin filament 0.0449984184786084 118 135 4 0.0296296296296296 0.0338983050847458
GO:CC GO:0015630 microtubule cytoskeleton 0.0458845951858635 1307 63 10 0.158730158730159 0.00765110941086458
GO:MF GO:0070492 oligosaccharide binding 0.00107804133267152 15 40 3 0.075 0.2
GO:MF GO:0050839 cell adhesion molecule binding 0.00107804133267152 546 80 12 0.15 0.021978021978022
GO:MF GO:0015929 hexosaminidase activity 0.0108664232307008 16 103 3 0.029126213592233 0.1875
GO:MF GO:0019838 growth factor binding 0.0108664232307008 138 62 5 0.0806451612903226 0.036231884057971
GO:MF GO:0045296 cadherin binding 0.0109243517245039 333 69 7 0.101449275362319 0.021021021021021
GO:MF GO:0008237 metallopeptidase activity 0.0109243517245039 188 55 5 0.0909090909090909 0.0265957446808511
GO:MF GO:0005539 glycosaminoglycan binding 0.0109243517245039 238 41 5 0.121951219512195 0.0210084033613445
GO:MF GO:0004222 metalloendopeptidase activity 0.0113514671235832 108 55 4 0.0727272727272727 0.037037037037037
GO:MF GO:0001530 lipopolysaccharide binding 0.0130877411603878 32 88 3 0.0340909090909091 0.09375
GO:MF GO:0005509 calcium ion binding 0.0130877411603878 721 127 14 0.110236220472441 0.0194174757281553
GO:MF GO:0005540 hyaluronic acid binding 0.0130877411603878 28 102 3 0.0294117647058824 0.107142857142857
GO:MF GO:0043236 laminin binding 0.0162516253308075 28 130 3 0.0230769230769231 0.107142857142857
GO:MF GO:0004714 transmembrane receptor protein tyrosine kinase activity 0.0211671973841929 63 67 3 0.0447761194029851 0.0476190476190476
GO:MF GO:0003779 actin binding 0.021218670177717 448 135 10 0.0740740740740741 0.0223214285714286
GO:MF GO:0097367 carbohydrate derivative binding 0.0228404961380991 2285 88 21 0.238636363636364 0.00919037199124726
GO:MF GO:0048306 calcium-dependent protein binding 0.0230386458725272 82 119 4 0.0336134453781513 0.0487804878048781
GO:MF GO:0019199 transmembrane receptor protein kinase activity 0.0301691344182846 82 67 3 0.0447761194029851 0.0365853658536585
GO:MF GO:0008233 peptidase activity 0.0301691344182846 646 88 9 0.102272727272727 0.0139318885448916
GO:MF GO:0001784 phosphotyrosine residue binding 0.030462413154784 44 131 3 0.0229007633587786 0.0681818181818182
GO:MF GO:0005178 integrin binding 0.0323677429677325 147 41 3 0.0731707317073171 0.0204081632653061
GO:MF GO:0008092 cytoskeletal protein binding 0.0334237423944381 996 60 9 0.15 0.00903614457831325
GO:MF GO:1990782 protein tyrosine kinase binding 0.0395436628771281 100 69 3 0.0434782608695652 0.03
GO:MF GO:0140096 catalytic activity, acting on a protein 0.0395436628771281 2332 113 24 0.212389380530973 0.0102915951972556
GO:MF GO:0050840 extracellular matrix binding 0.0429174220841424 56 130 3 0.0230769230769231 0.0535714285714286
GO:MF GO:0045309 protein phosphorylated amino acid binding 0.0429174220841424 56 131 3 0.0229007633587786 0.0535714285714286
GO:MF GO:0004713 protein tyrosine kinase activity 0.0442792321975098 144 101 4 0.0396039603960396 0.0277777777777778
REAC REAC:R-HSA-194138 Signaling by VEGF 0.00915566045620647 104 95 7 0.0736842105263158 0.0673076923076923
REAC REAC:R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.00915566045620647 94 95 7 0.0736842105263158 0.074468085106383
REAC REAC:R-HSA-446107 Type I hemidesmosome assembly 0.0133813365298706 11 94 3 0.0319148936170213 0.272727272727273
REAC REAC:R-HSA-202733 Cell surface interactions at the vascular wall 0.0133813365298706 190 62 7 0.112903225806452 0.0368421052631579
REAC REAC:R-HSA-446728 Cell junction organization 0.0141064191293011 91 94 6 0.0638297872340425 0.0659340659340659
REAC REAC:R-HSA-167044 Signalling to RAS 0.0161837237977679 17 79 3 0.0379746835443038 0.176470588235294
REAC REAC:R-HSA-109582 Hemostasis 0.0161837237977679 657 85 15 0.176470588235294 0.0228310502283105
REAC REAC:R-HSA-1500931 Cell-Cell communication 0.0423250753844005 127 94 6 0.0638297872340425 0.047244094488189
TF TF:M09724 Factor: DATF1; motif: SNGGRRGCWGNGGG 0.0112548145252835 8400 79 53 0.670886075949367 0.00630952380952381
TF TF:M07040 Factor: GKLF; motif: NNRRGRRNGNSNNN 0.0112548145252835 12705 87 74 0.850574712643678 0.00582447855175128
TF TF:M05444_1 Factor: CPBP; motif: NGGGCGG; match class: 1 0.0112548145252835 3313 111 37 0.333333333333333 0.0111681255659523
TF TF:M07040_1 Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 0.0112548145252835 8156 131 80 0.610687022900763 0.00980872976949485
TF TF:M00518 Factor: PPARalpha:RXRalpha; motif: NNRGGTCATWGGGGTSANG 0.0112548145252835 9501 76 55 0.723684210526316 0.00578886433007052
TF TF:M02111_1 Factor: NR1B2; motif: NTGACCY; match class: 1 0.0112548145252835 3323 83 31 0.373493975903614 0.00932891965091785
TF TF:M10045_1 Factor: RAR-gamma; motif: RGGTCANNNTGNCCNNNN; match class: 1 0.0112548145252835 1965 34 14 0.411764705882353 0.00712468193384224
TF TF:M05361_1 Factor: Sp6; motif: WGGGCGG; match class: 1 0.0112548145252835 3313 111 37 0.333333333333333 0.0111681255659523
TF TF:M05332_1 Factor: Sp2; motif: WGGGCGG; match class: 1 0.0112548145252835 3313 111 37 0.333333333333333 0.0111681255659523
TF TF:M09643 Factor: p63; motif: NNRCAWGYCTGGRCWTGYN 0.0126049650055711 3928 62 27 0.435483870967742 0.00687372708757637
TF TF:M08906 Factor: TR4; motif: NCCCTGACCYB 0.0146951475433576 4530 134 52 0.388059701492537 0.0114790286975717
TF TF:M10550_1 Factor: ZNF684; motif: MAAGGGGTGGACTGT; match class: 1 0.0146951475433576 9336 125 82 0.656 0.00878320479862896
TF TF:M12187 Factor: KLF17; motif: NMCCACNCWCCCNTN 0.0146951475433576 2886 134 38 0.283582089552239 0.0131670131670132
TF TF:M00257 Factor: RREB-1; motif: CCCCAAACMMCCCC 0.0178360318160466 10516 137 96 0.700729927007299 0.00912894636744009
TF TF:M00051_1 Factor: NF-kappaB; motif: GGGGATYCCC; match class: 1 0.0188666718414862 2797 126 35 0.277777777777778 0.0125134072220236
TF TF:M10432 Factor: MAZ; motif: GGGMGGGGS 0.0191688205632456 9259 131 84 0.641221374045801 0.00907225402311265
TF TF:M10432_1 Factor: MAZ; motif: GGGMGGGGS; match class: 1 0.0206648826304973 4365 79 33 0.417721518987342 0.00756013745704467
TF TF:M01801 Factor: ER-alpha; motif: AGGTCACNGTGACCT 0.0206648826304973 3396 111 36 0.324324324324324 0.0106007067137809
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.0206648826304973 3919 131 45 0.343511450381679 0.0114825210512886
TF TF:M12354 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN 0.0206648826304973 10961 87 66 0.758620689655172 0.00602134841711523
TF TF:M01858 Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN 0.0237461967557083 7418 129 70 0.542635658914729 0.0094365057967107
TF TF:M09907_1 Factor: Erg; motif: NRRSAGGAAGNGG; match class: 1 0.0262012436423027 5070 74 34 0.459459459459459 0.00670611439842209
TF TF:M11577_1 Factor: BF-1; motif: NACRYMMACAN; match class: 1 0.0262012436423027 177 11 3 0.272727272727273 0.0169491525423729
TF TF:M04689 Factor: CTCF; motif: NNNNANASYGCCMYCTAGTGG 0.0262012436423027 5648 40 23 0.575 0.00407223796033994
TF TF:M10014 Factor: FXR; motif: NRGGKCANTGRCCNNNNGG 0.0262012436423027 5652 40 23 0.575 0.00406935598018401
TF TF:M11423 Factor: Erm; motif: RSAGGAAGGAAGTN 0.0262012436423027 4841 98 41 0.418367346938776 0.00846932451972733
TF TF:M01865 Factor: BTEB3; motif: BNRNGGGAGGNGT 0.0262012436423027 9899 119 80 0.672268907563025 0.00808162440650571
TF TF:M07602_1 Factor: CP2; motif: NNNNCCAGNCNN; match class: 1 0.0262012436423027 4627 86 36 0.418604651162791 0.00778041927814999
TF TF:M01835 Factor: GKLF; motif: CCTCCYN 0.0262012436423027 15620 77 73 0.948051948051948 0.00467349551856594
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.0262012436423027 7557 73 44 0.602739726027397 0.00582241630276565
TF TF:M03852_1 Factor: SREBP-2; motif: NTCACCYNNNN; match class: 1 0.0276965350453072 2246 4 4 1 0.00178094390026714
TF TF:M08819_1 Factor: LKLF; motif: CNCCACCCS; match class: 1 0.0276965350453072 1532 90 18 0.2 0.0117493472584856
TF TF:M06181 Factor: CT53; motif: NCGGGGTGACGC 0.0276965350453072 27 76 3 0.0394736842105263 0.111111111111111
TF TF:M09972 Factor: BTEB2; motif: WGGGTGKGGCNGGN 0.0276965350453072 9217 138 86 0.623188405797101 0.00933058478897689
TF TF:M04738 Factor: ER-alpha; motif: AGGTCANMNTGACC 0.0276965350453072 4374 85 34 0.4 0.0077732053040695
TF TF:M09760_1 Factor: DPF2; motif: NYCACYTCCYCNYYCY; match class: 1 0.0276965350453072 2978 70 23 0.328571428571429 0.00772330423102754
TF TF:M00444 Factor: VDR; motif: GGGKNARNRRGGWSA 0.0276965350453072 10308 75 55 0.733333333333333 0.00533566162204113
TF TF:M07436_1 Factor: WT1; motif: NNGGGNGGGSGN; match class: 1 0.0277800064223672 2405 119 29 0.243697478991597 0.0120582120582121
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.0277800064223672 3962 138 46 0.333333333333333 0.0116102978293791
TF TF:M08896 Factor: SIP1; motif: MRDSCAGGTGKCMCM 0.0295294111993129 669 62 9 0.145161290322581 0.0134529147982063
TF TF:M09744 Factor: CTCF; motif: NNYGCCCYCTRSTGGN 0.0295294111993129 3838 104 36 0.346153846153846 0.00937988535695675
TF TF:M09843 Factor: GABPBETA; motif: YCACTTCCKGN 0.0295294111993129 2553 48 16 0.333333333333333 0.00626713670191931
TF TF:M09739 Factor: ZGPAT; motif: GRGGCWGNGGNG 0.0295294111993129 8226 103 61 0.592233009708738 0.00741551179187941
TF TF:M07461_1 Factor: KLF; motif: GGGNGGGG; match class: 1 0.0295294111993129 3397 92 30 0.326086956521739 0.00883132175448926
TF TF:M09859 Factor: NF90; motif: NCCNCWGCCYCCNC 0.0295294111993129 4735 84 35 0.416666666666667 0.00739176346356917
TF TF:M09977_1 Factor: Lyl-1; motif: NCAKCTGYTNYCNN; match class: 1 0.0295294111993129 7633 58 36 0.620689655172414 0.00471636315996332
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.0295294111993129 7508 79 46 0.582278481012658 0.00612679808204582
TF TF:M07251 Factor: EHF; motif: BTTCCTGC 0.0295294111993129 6174 57 31 0.543859649122807 0.0050210560414642
TF TF:M08825 Factor: NF-1B; motif: KCCAGANWN 0.0295294111993129 5811 18 13 0.722222222222222 0.00223713646532438
TF TF:M03839 Factor: Pax-2; motif: CAYSCCTSAGT 0.0295294111993129 5052 118 48 0.406779661016949 0.00950118764845606
TF TF:M08906_1 Factor: TR4; motif: NCCCTGACCYB; match class: 1 0.0295294111993129 743 57 9 0.157894736842105 0.0121130551816958
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.0295294111993129 8031 77 47 0.61038961038961 0.0058523222512763
TF TF:M00491 Factor: MAZR; motif: NSGGGGGGGGMCN 0.0295294111993129 1207 86 15 0.174418604651163 0.0124275062137531
TF TF:M02242 Factor: CTCF; motif: YNRCCASYAGRKGGCRSYN 0.0295294111993129 5877 90 43 0.477777777777778 0.00731665815892462
TF TF:M01835_1 Factor: GKLF; motif: CCTCCYN; match class: 1 0.0296582483967085 10142 77 55 0.714285714285714 0.00542299349240781
TF TF:M02101_1 Factor: myogenin; motif: CAGCTG; match class: 1 0.029779231730327 12960 95 78 0.821052631578947 0.00601851851851852
TF TF:M00776 Factor: SREBP; motif: VNNVTCACCCYA 0.029779231730327 6530 17 13 0.764705882352941 0.00199081163859112
TF TF:M02101 Factor: myogenin; motif: CAGCTG 0.029779231730327 12960 95 78 0.821052631578947 0.00601851851851852
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.029779231730327 8944 138 83 0.601449275362319 0.00927996422182469
TF TF:M10151 Factor: EZI; motif: GGGGAGGGGRRGGRGRRGGRRR 0.029779231730327 2108 70 18 0.257142857142857 0.00853889943074004
TF TF:M02088_1 Factor: E2A; motif: NRMCASCTGCNNN; match class: 1 0.029779231730327 315 57 6 0.105263157894737 0.019047619047619
TF TF:M04595_1 Factor: SALL2; motif: GGGTGGG; match class: 1 0.029779231730327 7373 79 45 0.569620253164557 0.0061033500610335
TF TF:M09671 Factor: VDR; motif: RRGGTCANNGRGKTCA 0.029779231730327 8106 123 70 0.569105691056911 0.00863557858376511
TF TF:M00531_1 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS; match class: 1 0.029779231730327 1902 97 21 0.216494845360825 0.0110410094637224
TF TF:M03852 Factor: SREBP-2; motif: NTCACCYNNNN 0.029779231730327 8142 18 15 0.833333333333333 0.00184229918938836
TF TF:M02023_1 Factor: MAZ; motif: NKGGGAGGGGRGGR; match class: 1 0.029779231730327 3112 138 38 0.27536231884058 0.0122107969151671
TF TF:M01860 Factor: AP-4; motif: NCAGCTGYNGNCN 0.02989011085267 5995 129 58 0.449612403100775 0.00967472894078399
TF TF:M11842 Factor: ER-alpha; motif: NAGGTCAYSGYGACCTN 0.0312973621002969 4035 102 36 0.352941176470588 0.00892193308550186
TF TF:M04617 Factor: LRF; motif: NGNAGNGGGTYN 0.0317411994263653 6164 121 56 0.462809917355372 0.009085009733939
TF TF:M12026_1 Factor: TBX2; motif: NNNGTGTSNN; match class: 1 0.0345492123516897 1911 112 23 0.205357142857143 0.0120355834641549
TF TF:M11827_1 Factor: LRH-1; motif: YGACCTTGNNNCAAGGTCR; match class: 1 0.0361982757240051 584 47 7 0.148936170212766 0.011986301369863
TF TF:M11485_1 Factor: CP2; motif: AACCGGTTNNAACCGGTT; match class: 1 0.0361982757240051 6203 134 61 0.455223880597015 0.00983395131388038
TF TF:M07469_1 Factor: Tal; motif: GWSNNCABCTGC; match class: 1 0.0364784476321982 746 116 13 0.112068965517241 0.017426273458445
TF TF:M07260_1 Factor: Ikaros; motif: TGGGAGN; match class: 1 0.0364784476321982 7187 120 62 0.516666666666667 0.0086266870738834
TF TF:M09790 Factor: TWIST1; motif: NNNCCAGATGTNN 0.0364784476321982 2903 29 12 0.413793103448276 0.00413365483982087
TF TF:M09910 Factor: ER-beta; motif: RGGTCASCNTGMCCY 0.0367454193602234 9520 130 82 0.630769230769231 0.00861344537815126
TF TF:M01100_1 Factor: LRF; motif: GGGGKYNNB; match class: 1 0.0379438681246917 2762 71 21 0.295774647887324 0.00760318609703114
TF TF:M03819 Factor: Elk-1; motif: GGAAGN 0.0379438681246917 14241 56 51 0.910714285714286 0.00358120918474826
TF TF:M09916 Factor: Erm; motif: NRRSAGGAARNGRN 0.0379438681246917 6711 31 20 0.645161290322581 0.00298018179108926
TF TF:M07042_1 Factor: HES-1; motif: NNCKYGTGNNN; match class: 1 0.0379438681246917 661 56 8 0.142857142857143 0.0121028744326778
TF TF:M07611 Factor: p54NRB; motif: GRNNNMGGATGRMNNCGGA 0.0379438681246917 6991 32 21 0.65625 0.00300386210842512
TF TF:M00531 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS 0.0379438681246917 7615 74 43 0.581081081081081 0.0056467498358503
TF TF:M10025 Factor: p73; motif: NNRCAWGYCCARRCWTGYC 0.0379438681246917 6293 97 47 0.484536082474227 0.00746861592245352
TF TF:M07611_1 Factor: p54NRB; motif: GRNNNMGGATGRMNNCGGA; match class: 1 0.0379438681246917 1645 92 18 0.195652173913043 0.0109422492401216
TF TF:M09671_1 Factor: VDR; motif: RRGGTCANNGRGKTCA; match class: 1 0.0380037448980783 2412 138 31 0.22463768115942 0.0128524046434494
TF TF:M04689_1 Factor: CTCF; motif: NNNNANASYGCCMYCTAGTGG; match class: 1 0.0381624170808201 940 61 10 0.163934426229508 0.0106382978723404
TF TF:M04802 Factor: c-Fos; motif: ACTCACCA 0.0381624170808201 7386 57 34 0.596491228070175 0.00460330354725156
TF TF:M03820_1 Factor: ER-alpha; motif: GGNNNNNNTGACCYN; match class: 1 0.0381624170808201 277 73 6 0.0821917808219178 0.0216606498194946
TF TF:M10068 Factor: Sox-3; motif: NCCTTTGTNYN 0.0381624170808201 1650 14 6 0.428571428571429 0.00363636363636364
TF TF:M10008_1 Factor: CSX; motif: NKRAGWGS; match class: 1 0.0381624170808201 3963 55 22 0.4 0.0055513499873833
TF TF:M11797 Factor: NR1B1; motif: NRAGGTCANG 0.0381624170808201 1948 21 8 0.380952380952381 0.00410677618069815
TF TF:M09973_1 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 0.039412244582823 6607 138 65 0.471014492753623 0.00983805055244438
TF TF:M02023 Factor: MAZ; motif: NKGGGAGGGGRGGR 0.039412244582823 7134 72 40 0.555555555555556 0.00560695262125035
TF TF:M07260 Factor: Ikaros; motif: TGGGAGN 0.039412244582823 13523 138 112 0.811594202898551 0.00828218590549434
TF TF:M07405 Factor: SREBP-1; motif: RTCACCCCAY 0.0415401964879479 6972 17 13 0.764705882352941 0.00186460126219162
TF TF:M09746_1 Factor: HNRPUL1; motif: NCNCAGN; match class: 1 0.0415401964879479 7619 83 47 0.566265060240964 0.00616878855492847
TF TF:M07261_1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 0.0420050779415665 4062 79 29 0.367088607594937 0.00713934022648941
TF TF:M04863_1 Factor: TF3C-beta; motif: CCNGGAGGGCTTCCTGGAGGAG; match class: 1 0.0420050779415665 8573 112 66 0.589285714285714 0.00769858859209145
TF TF:M02111 Factor: NR1B2; motif: NTGACCY 0.0420050779415665 9671 75 51 0.68 0.00527349808706442
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0420050779415665 7710 112 61 0.544642857142857 0.00791180285343709
TF TF:M00693 Factor: E12; motif: RRCAGGTGNCV 0.0421613299956207 2997 129 34 0.263565891472868 0.0113446780113447
TF TF:M09984_1 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 0.0421613299956207 5555 79 36 0.455696202531646 0.00648064806480648
TF TF:M07354_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0421613299956207 3561 131 39 0.297709923664122 0.0109519797809604
TF TF:M08623 Factor: rfx3:SRF; motif: TRGCAACNNNNNCCNWATANGGN 0.0436015504607179 14645 65 59 0.907692307692308 0.00402867872994196
TF TF:M00706_1 Factor: TFII-I; motif: RGAGGKAGG; match class: 1 0.0436015504607179 1590 131 22 0.16793893129771 0.0138364779874214
TF TF:M03896 Factor: EGR1; motif: NACGCCCACGCANW 0.0436015504607179 6129 138 61 0.442028985507246 0.00995268396149453
TF TF:M08623_1 Factor: rfx3:SRF; motif: TRGCAACNNNNNCCNWATANGGN; match class: 1 0.0436015504607179 8140 63 39 0.619047619047619 0.00479115479115479
TF TF:M00051 Factor: NF-kappaB; motif: GGGGATYCCC 0.0440512268365125 6413 130 60 0.461538461538462 0.0093559956338687
TF TF:M05405 Factor: Zbtb44; motif: CKGTGA 0.0440512268365125 13842 60 53 0.883333333333333 0.00382892645571449
TF TF:M08585 Factor: GCMa:T-bet; motif: NGGTGTNANNNNNNNNTNNCATRCGGGY 0.0460006060065777 56 65 3 0.0461538461538462 0.0535714285714286
TF TF:M01200 Factor: CTCF; motif: NNNGCCASCAGRKGGCRSNN 0.0464139166966674 3956 124 40 0.32258064516129 0.0101112234580384
TF TF:M09760 Factor: DPF2; motif: NYCACYTCCYCNYYCY 0.0464139166966674 8179 71 43 0.605633802816901 0.00525736642621347
TF TF:M09909 Factor: ER-alpha; motif: AGGTCASMNTGACCY 0.0464139166966674 6836 111 55 0.495495495495495 0.00804564072557051
TF TF:M12249 Factor: LIN28B; motif: CGCGATANNACNGCG 0.0464139166966674 279 53 5 0.0943396226415094 0.017921146953405
TF TF:M11759 Factor: HNF-4alpha; motif: RRGGTCAAAGTCCAN 0.0464139166966674 2090 21 8 0.380952380952381 0.00382775119617225
TF TF:M08891_1 Factor: NFKAPPAB; motif: NNGGGANTTCCCN; match class: 1 0.0464139166966674 181 121 6 0.0495867768595041 0.0331491712707182
TF TF:M03806_1 Factor: ZBTB7C; motif: GKCCCGGGCKG; match class: 1 0.0464139166966674 544 129 11 0.0852713178294574 0.0202205882352941
TF TF:M12102 Factor: ZBTB26; motif: NNTCYAGAAAAN 0.0464139166966674 237 36 4 0.111111111111111 0.0168776371308017
TF TF:M04622 Factor: Nur77; motif: RAAGGTCANN 0.047811522462414 790 20 5 0.25 0.00632911392405063
TF TF:M00470_1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 0.047811522462414 5600 119 50 0.420168067226891 0.00892857142857143
TF TF:M11017 Factor: DPRX; motif: AGATAATCCN 0.047811522462414 930 5 3 0.6 0.0032258064516129
TF TF:M08019 Factor: RARA; motif: AGGTCANNYAAAGGTCA 0.047811522462414 5530 86 38 0.441860465116279 0.00687160940325497
TF TF:M11815 Factor: T3R-beta; motif: NNRGGTCRTGACCYNN 0.047811522462414 5327 31 17 0.548387096774194 0.00319128965646705
TF TF:M06151 Factor: ZNF84; motif: NCCTMCGGMAGA 0.047811522462414 160 54 4 0.0740740740740741 0.025
TF TF:M11843 Factor: ER-alpha; motif: NAGGTCACSGTGACCTN 0.0481116725631444 3743 127 39 0.307086614173228 0.0104194496393267
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.0482140655468743 14096 77 67 0.87012987012987 0.00475312145289444
TF TF:M00665_1 Factor: Sp3; motif: ASMCTTGGGSRGGG; match class: 1 0.0486936045605304 2293 71 18 0.253521126760563 0.00784997819450502
TF TF:M00176 Factor: AP-4; motif: CWCAGCTGGN 0.049090331698711 2528 137 31 0.226277372262774 0.0122626582278481
TF TF:M10115 Factor: LRF; motif: NRGGGKCKY 0.0492352884658797 7623 119 63 0.529411764705882 0.00826446280991736
TF TF:M08818 Factor: KLF8; motif: NGGGGTGYGG 0.0492352884658797 1590 69 14 0.202898550724638 0.00880503144654088
TF TF:M07284_1 Factor: Erg; motif: MCAGGAAA; match class: 1 0.0492352884658797 4412 75 29 0.386666666666667 0.00657298277425204

pS25 transcription factor target enrichment of top program genes

TF enrichment of pS25
TFs corrosponding to activation of pS25. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.