pEpiTp05 program activity among Epithelial cells

Activation of pEpiTp05
pEpiTp05 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp05 by different cell subtypes
pEpiTp05 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp05 top program genes

Top genes of pEpiTp05 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp05 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp05
pEpiTp05 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:306 Ribosome, cytoplasmic 1.09292984524712e-15 80 17 12 0.705882352941177 0.15
CORUM CORUM:3055 Nop56p-associated pre-rRNA complex 2.60352815116075e-13 104 12 10 0.833333333333333 0.0961538461538462
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 1.17397647145602e-12 47 17 9 0.529411764705882 0.191489361702128
CORUM CORUM:5380 TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) 3.34641516586003e-05 25 17 4 0.235294117647059 0.16
CORUM CORUM:338 40S ribosomal subunit, cytoplasmic 0.000803210421271609 31 12 3 0.25 0.0967741935483871
CORUM CORUM:305 40S ribosomal subunit, cytoplasmic 0.000809410877169821 33 12 3 0.25 0.0909090909090909
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 5.94959093169247e-22 96 17 12 0.705882352941177 0.125
GO:BP GO:0006613 cotranslational protein targeting to membrane 6.42380894147039e-22 102 17 12 0.705882352941177 0.117647058823529
GO:BP GO:0045047 protein targeting to ER 1.56206908416883e-21 113 17 12 0.705882352941177 0.106194690265487
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 1.81510951728114e-21 117 17 12 0.705882352941177 0.102564102564103
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 2.72100825417603e-21 123 17 12 0.705882352941177 0.0975609756097561
GO:BP GO:0006413 translational initiation 3.48761556600287e-21 201 17 13 0.764705882352941 0.0646766169154229
GO:BP GO:0019080 viral gene expression 3.48761556600287e-21 199 17 13 0.764705882352941 0.0653266331658292
GO:BP GO:0070972 protein localization to endoplasmic reticulum 1.44672537789911e-20 146 17 12 0.705882352941177 0.0821917808219178
GO:BP GO:0019083 viral transcription 1.84121177903161e-19 181 17 12 0.705882352941177 0.0662983425414365
GO:BP GO:0006612 protein targeting to membrane 7.22432803464572e-19 204 17 12 0.705882352941177 0.0588235294117647
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 1.18169930181459e-18 214 17 12 0.705882352941177 0.0560747663551402
GO:BP GO:0006412 translation 8.89763056471998e-18 764 17 15 0.882352941176471 0.0196335078534031
GO:BP GO:0043043 peptide biosynthetic process 1.35922064822461e-17 790 17 15 0.882352941176471 0.0189873417721519
GO:BP GO:0043604 amide biosynthetic process 1.51409649816161e-16 932 17 15 0.882352941176471 0.0160944206008584
GO:BP GO:0016032 viral process 1.6586994558786e-16 942 17 15 0.882352941176471 0.0159235668789809
GO:BP GO:0006518 peptide metabolic process 1.91019357548382e-16 955 17 15 0.882352941176471 0.0157068062827225
GO:BP GO:0090150 establishment of protein localization to membrane 3.16688945895632e-16 351 17 12 0.705882352941177 0.0341880341880342
GO:BP GO:0044403 biological process involved in symbiotic interaction 3.43893687856545e-16 1001 17 15 0.882352941176471 0.014985014985015
GO:BP GO:0006402 mRNA catabolic process 8.39587480298114e-16 384 17 12 0.705882352941177 0.03125
GO:BP GO:0006401 RNA catabolic process 2.63552386398186e-15 424 17 12 0.705882352941177 0.0283018867924528
GO:BP GO:0006605 protein targeting 4.02977766868787e-15 441 17 12 0.705882352941177 0.0272108843537415
GO:BP GO:0043603 cellular amide metabolic process 7.0271225419373e-15 1241 17 15 0.882352941176471 0.0120870265914585
GO:BP GO:0034655 nucleobase-containing compound catabolic process 7.51408125572057e-14 567 17 12 0.705882352941177 0.0211640211640212
GO:BP GO:0072594 establishment of protein localization to organelle 1.02542725252217e-13 584 17 12 0.705882352941177 0.0205479452054795
GO:BP GO:0046700 heterocycle catabolic process 1.41518855371259e-13 602 17 12 0.705882352941177 0.0199335548172757
GO:BP GO:0016071 mRNA metabolic process 1.49725365331486e-13 874 20 14 0.7 0.0160183066361556
GO:BP GO:0044270 cellular nitrogen compound catabolic process 1.49725365331486e-13 608 17 12 0.705882352941177 0.0197368421052632
GO:BP GO:0019439 aromatic compound catabolic process 1.90337135962668e-13 623 17 12 0.705882352941177 0.0192616372391653
GO:BP GO:1901361 organic cyclic compound catabolic process 3.10600536426812e-13 651 17 12 0.705882352941177 0.0184331797235023
GO:BP GO:0072657 protein localization to membrane 3.86993031996029e-13 665 17 12 0.705882352941177 0.0180451127819549
GO:BP GO:1901566 organonitrogen compound biosynthetic process 1.9575509196471e-12 1853 17 15 0.882352941176471 0.00809498111171074
GO:BP GO:0044265 cellular macromolecule catabolic process 1.45756741019269e-11 1231 17 13 0.764705882352941 0.0105605199025183
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 3.37152266289701e-11 2255 17 15 0.882352941176471 0.00665188470066519
GO:BP GO:0033365 protein localization to organelle 5.26925012059334e-11 1017 17 12 0.705882352941177 0.0117994100294985
GO:BP GO:0009057 macromolecule catabolic process 1.24052020517966e-10 1468 12 11 0.916666666666667 0.00749318801089918
GO:BP GO:0006886 intracellular protein transport 3.03634604686159e-10 1186 17 12 0.705882352941177 0.0101180438448567
GO:BP GO:0010629 negative regulation of gene expression 3.35568130561324e-09 1460 17 12 0.705882352941177 0.00821917808219178
GO:BP GO:1901575 organic substance catabolic process 1.31896161563529e-08 2267 12 11 0.916666666666667 0.00485222761358624
GO:BP GO:0044248 cellular catabolic process 1.87498715826941e-08 2347 12 11 0.916666666666667 0.00468683425649766
GO:BP GO:0046907 intracellular transport 2.83808587662588e-08 1767 17 12 0.705882352941177 0.0067911714770798
GO:BP GO:0015031 protein transport 7.60470907367263e-08 1929 17 12 0.705882352941177 0.00622083981337481
GO:BP GO:0015833 peptide transport 9.30331656346135e-08 1971 17 12 0.705882352941177 0.0060882800608828
GO:BP GO:0009056 catabolic process 9.30331656346135e-08 2744 12 11 0.916666666666667 0.00400874635568513
GO:BP GO:0042886 amide transport 1.11183465306464e-07 2007 17 12 0.705882352941177 0.00597907324364723
GO:BP GO:0034613 cellular protein localization 1.11183465306464e-07 2014 17 12 0.705882352941177 0.00595829195630586
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 1.11183465306464e-07 446 20 8 0.4 0.0179372197309417
GO:BP GO:0070727 cellular macromolecule localization 1.15173779360081e-07 2024 17 12 0.705882352941177 0.00592885375494071
GO:BP GO:0045184 establishment of protein localization 1.19999807605803e-07 2035 17 12 0.705882352941177 0.0058968058968059
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 1.23422295842169e-07 5017 17 16 0.941176470588235 0.00318915686665338
GO:BP GO:0034645 cellular macromolecule biosynthetic process 1.34456942085055e-07 5051 17 16 0.941176470588235 0.00316768956642249
GO:BP GO:0009059 macromolecule biosynthetic process 1.60070998470966e-07 5114 17 16 0.941176470588235 0.00312866640594447
GO:BP GO:0002181 cytoplasmic translation 2.4827410741305e-07 103 17 5 0.294117647058824 0.0485436893203883
GO:BP GO:0071705 nitrogen compound transport 4.68046838785018e-07 2322 12 10 0.833333333333333 0.00430663221360896
GO:BP GO:0016070 RNA metabolic process 7.14556989677001e-07 4710 12 12 1 0.00254777070063694
GO:BP GO:0010467 gene expression 9.34159674043352e-07 6179 21 19 0.904761904761905 0.00307493121864379
GO:BP GO:0010468 regulation of gene expression 2.24177243710276e-06 5196 12 12 1 0.0023094688221709
GO:BP GO:0008104 protein localization 2.33827460742604e-06 2770 12 10 0.833333333333333 0.0036101083032491
GO:BP GO:0071702 organic substance transport 2.33827460742604e-06 2766 12 10 0.833333333333333 0.00361532899493854
GO:BP GO:0090304 nucleic acid metabolic process 2.33827460742604e-06 5226 12 12 1 0.00229621125143513
GO:BP GO:0044249 cellular biosynthetic process 2.44688334220266e-06 6154 17 16 0.941176470588235 0.00259993500162496
GO:BP GO:0034641 cellular nitrogen compound metabolic process 2.49711799313622e-06 6563 21 19 0.904761904761905 0.00289501752247448
GO:BP GO:0051649 establishment of localization in cell 2.58337448938177e-06 2813 12 10 0.833333333333333 0.00355492356914326
GO:BP GO:1901576 organic substance biosynthetic process 2.9495729345284e-06 6248 17 16 0.941176470588235 0.00256081946222791
GO:BP GO:0006820 anion transport 3.23967035271654e-06 2889 12 10 0.833333333333333 0.00346140533056421
GO:BP GO:0044267 cellular protein metabolic process 3.55897236740962e-06 5229 17 15 0.882352941176471 0.00286861732644865
GO:BP GO:0009058 biosynthetic process 3.55897236740962e-06 6340 17 16 0.941176470588235 0.00252365930599369
GO:BP GO:0006139 nucleobase-containing compound metabolic process 6.27467549590134e-06 5746 12 12 1 0.00208840932822833
GO:BP GO:0033036 macromolecule localization 8.51145282495369e-06 3218 12 10 0.833333333333333 0.00310752019888129
GO:BP GO:0046483 heterocycle metabolic process 8.51145282495369e-06 5904 12 12 1 0.00203252032520325
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 8.98532335813799e-06 3241 12 10 0.833333333333333 0.00308546744831842
GO:BP GO:0006725 cellular aromatic compound metabolic process 9.11281699659351e-06 5956 12 12 1 0.00201477501678979
GO:BP GO:1901360 organic cyclic compound metabolic process 1.4383448638126e-05 6201 12 12 1 0.0019351717464925
GO:BP GO:0019538 protein metabolic process 1.4383448638126e-05 5808 17 15 0.882352941176471 0.00258264462809917
GO:BP GO:0009892 negative regulation of metabolic process 1.67924653078944e-05 3479 12 10 0.833333333333333 0.00287438919229664
GO:BP GO:0051641 cellular localization 1.96257041953075e-05 3541 12 10 0.833333333333333 0.00282406099971759
GO:BP GO:0006811 ion transport 2.66453946183159e-05 3661 12 10 0.833333333333333 0.00273149412728763
GO:BP GO:0042254 ribosome biogenesis 2.69199902443435e-05 307 16 5 0.3125 0.0162866449511401
GO:BP GO:0060255 regulation of macromolecule metabolic process 2.86238357277617e-05 6603 12 12 1 0.00181735574738755
GO:BP GO:0006364 rRNA processing 3.63124503304795e-05 224 11 4 0.363636363636364 0.0178571428571429
GO:BP GO:0016072 rRNA metabolic process 4.26199912435125e-05 234 11 4 0.363636363636364 0.0170940170940171
GO:BP GO:0019222 regulation of metabolic process 7.14476125574459e-05 7148 12 12 1 0.00167879127028539
GO:BP GO:0006396 RNA processing 0.000106651356495873 964 24 8 0.333333333333333 0.00829875518672199
GO:BP GO:1901564 organonitrogen compound metabolic process 0.000113672754660547 6792 17 15 0.882352941176471 0.00220848056537102
GO:BP GO:0042273 ribosomal large subunit biogenesis 0.000171682451702708 74 16 3 0.1875 0.0405405405405405
GO:BP GO:0044260 cellular macromolecule metabolic process 0.000205095884586793 8390 17 16 0.941176470588235 0.00190703218116806
GO:BP GO:0034660 ncRNA metabolic process 0.000213546071188052 493 25 6 0.24 0.0121703853955375
GO:BP GO:0022618 ribonucleoprotein complex assembly 0.00026946980592802 197 20 4 0.2 0.0203045685279188
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 0.000304863285436676 204 20 4 0.2 0.0196078431372549
GO:BP GO:0034470 ncRNA processing 0.000304863285436676 397 11 4 0.363636363636364 0.0100755667506297
GO:BP GO:0048519 negative regulation of biological process 0.000566206385043709 5757 13 11 0.846153846153846 0.00191071738752823
GO:BP GO:0006810 transport 0.000612167538008189 5224 12 10 0.833333333333333 0.00191424196018377
GO:BP GO:0051234 establishment of localization 0.000785240808028456 5372 12 10 0.833333333333333 0.00186150409530901
GO:BP GO:0043170 macromolecule metabolic process 0.00141864809063063 9796 13 13 1 0.00132707227439771
GO:BP GO:0006807 nitrogen compound metabolic process 0.0020106689399758 10078 13 13 1 0.00128993847985711
GO:BP GO:0044238 primary metabolic process 0.003619798980852 10584 13 13 1 0.00122826908541194
GO:BP GO:0044237 cellular metabolic process 0.00507771937758558 10871 13 13 1 0.00119584214883635
GO:BP GO:0051179 localization 0.00692751678439003 6901 12 10 0.833333333333333 0.00144906535284741
GO:BP GO:0071704 organic substance metabolic process 0.00833774433103947 11326 13 13 1 0.0011478015186297
GO:BP GO:0044085 cellular component biogenesis 0.00986072125796252 3257 22 10 0.454545454545455 0.00307031010132023
GO:BP GO:0008152 metabolic process 0.0137568304372121 11827 13 13 1 0.00109917984273273
GO:BP GO:0050789 regulation of biological process 0.0176979765558177 12091 13 13 1 0.00107517988586552
GO:BP GO:0043933 protein-containing complex subunit organization 0.0224596556311215 1963 22 7 0.318181818181818 0.00356597045338767
GO:BP GO:0006417 regulation of translation 0.0233860891421502 462 16 3 0.1875 0.00649350649350649
GO:BP GO:0034248 regulation of cellular amide metabolic process 0.0336091401306869 535 16 3 0.1875 0.00560747663551402
GO:BP GO:0065007 biological regulation 0.034115390762436 12809 13 13 1 0.0010149113904286
GO:BP GO:0065003 protein-containing complex assembly 0.0388072258999021 1680 22 6 0.272727272727273 0.00357142857142857
GO:CC GO:0022626 cytosolic ribosome 4.34446391066148e-22 109 17 12 0.705882352941177 0.110091743119266
GO:CC GO:0005840 ribosome 2.38171017106273e-20 245 17 13 0.764705882352941 0.0530612244897959
GO:CC GO:0044391 ribosomal subunit 1.46842030744881e-19 190 17 12 0.705882352941177 0.0631578947368421
GO:CC GO:0022625 cytosolic large ribosomal subunit 6.34960908886088e-18 57 17 9 0.529411764705882 0.157894736842105
GO:CC GO:1990904 ribonucleoprotein complex 3.93595166246228e-15 688 20 14 0.7 0.0203488372093023
GO:CC GO:0015934 large ribosomal subunit 4.11017114624722e-15 118 17 9 0.529411764705882 0.076271186440678
GO:CC GO:0005730 nucleolus 1.72968723095685e-06 955 19 9 0.473684210526316 0.00942408376963351
GO:CC GO:0005829 cytosol 2.92448777410421e-06 5303 12 12 1 0.00226287007354328
GO:CC GO:0005925 focal adhesion 8.58176792886324e-06 420 16 6 0.375 0.0142857142857143
GO:CC GO:0030055 cell-substrate junction 8.58176792886324e-06 427 16 6 0.375 0.0140515222482436
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 2.06705210824037e-05 5338 13 12 0.923076923076923 0.00224803297115024
GO:CC GO:0043228 non-membrane-bounded organelle 2.06705210824037e-05 5346 13 12 0.923076923076923 0.00224466891133558
GO:CC GO:0022627 cytosolic small ribosomal subunit 2.44979907054871e-05 47 12 3 0.25 0.0638297872340425
GO:CC GO:0042788 polysomal ribosome 2.59092587249354e-05 34 17 3 0.176470588235294 0.0882352941176471
GO:CC GO:0032991 protein-containing complex 6.00442707111928e-05 5548 17 14 0.823529411764706 0.00252343186733958
GO:CC GO:0015935 small ribosomal subunit 8.20665629590041e-05 75 12 3 0.25 0.04
GO:CC GO:0031981 nuclear lumen 0.000188332281261074 4444 21 14 0.666666666666667 0.00315031503150315
GO:CC GO:0005844 polysome 0.000196657669527285 72 17 3 0.176470588235294 0.0416666666666667
GO:CC GO:0070161 anchoring junction 0.000214189335057097 836 16 6 0.375 0.00717703349282297
GO:CC GO:0070013 intracellular organelle lumen 0.00160639193633589 5402 21 14 0.666666666666667 0.00259163272861903
GO:CC GO:0043233 organelle lumen 0.00196423128158275 5565 21 14 0.666666666666667 0.00251572327044025
GO:CC GO:0031974 membrane-enclosed lumen 0.00196423128158275 5565 21 14 0.666666666666667 0.00251572327044025
GO:CC GO:0005737 cytoplasm 0.00812992625150149 11911 13 13 1 0.00109142809167996
GO:CC GO:0005634 nucleus 0.0124724237088462 7592 6 6 1 0.000790305584826133
GO:CC GO:0043229 intracellular organelle 0.0129332821452678 12491 13 13 1 0.00104074933952446
GO:CC GO:0030054 cell junction 0.0154656817951448 2105 16 6 0.375 0.00285035629453682
GO:CC GO:0043226 organelle 0.0446667321882111 14008 13 13 1 0.000928041119360366
GO:MF GO:0003735 structural constituent of ribosome 1.11703639964786e-19 171 17 12 0.705882352941177 0.0701754385964912
GO:MF GO:0003723 RNA binding 7.48155435919412e-13 1943 25 19 0.76 0.00977869274318065
GO:MF GO:0005198 structural molecule activity 9.41222783826468e-13 698 17 12 0.705882352941177 0.0171919770773639
GO:MF GO:0003676 nucleic acid binding 4.10111278714591e-07 4276 12 12 1 0.00280636108512629
GO:MF GO:1901363 heterocyclic compound binding 2.92447388115243e-05 6228 12 12 1 0.00192678227360308
GO:MF GO:0097159 organic cyclic compound binding 2.92447388115243e-05 6309 12 12 1 0.0019020446980504
GO:MF GO:0003729 mRNA binding 0.00245651063511532 552 5 3 0.6 0.00543478260869565
GO:MF GO:0045182 translation regulator activity 0.00245651063511532 155 15 3 0.2 0.0193548387096774
GO:MF GO:0045296 cadherin binding 0.00261661499193295 333 8 3 0.375 0.00900900900900901
GO:MF GO:0050839 cell adhesion molecule binding 0.00906878570580647 546 8 3 0.375 0.00549450549450549
GO:MF GO:0140098 catalytic activity, acting on RNA 0.0436938689156397 395 25 3 0.12 0.00759493670886076
HPA HPA:0150053 duodenum; glandular cells[High] 0.0248384661891849 2767 11 9 0.818181818181818 0.00325262016624503
HPA HPA:0350473 pancreas; exocrine glandular cells[High] 0.0248384661891849 1879 11 8 0.727272727272727 0.00425758382118148
KEGG KEGG:03010 Ribosome 9.70963283418789e-17 153 17 12 0.705882352941177 0.0784313725490196
KEGG KEGG:05171 Coronavirus disease - COVID-19 7.57293088731807e-15 231 17 12 0.705882352941177 0.051948051948052
MIRNA MIRNA:hsa-miR-615-3p hsa-miR-615-3p 0.0097215571726888 891 17 7 0.411764705882353 0.00785634118967452
MIRNA MIRNA:hsa-miR-331-3p hsa-miR-331-3p 0.0156767064909984 403 11 4 0.363636363636364 0.00992555831265509
MIRNA MIRNA:hsa-miR-484 hsa-miR-484 0.0365052033515373 890 19 6 0.315789473684211 0.00674157303370787
MIRNA MIRNA:hsa-miR-18a-3p hsa-miR-18a-3p 0.0485603204963319 348 10 3 0.3 0.00862068965517241
MIRNA MIRNA:hsa-miR-186-5p hsa-miR-186-5p 0.0485603204963319 749 19 5 0.263157894736842 0.00667556742323097
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 6.87260141193694e-22 102 17 13 0.764705882352941 0.127450980392157
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 9.3670353267644e-22 112 17 13 0.764705882352941 0.116071428571429
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 9.3670353267644e-22 113 17 13 0.764705882352941 0.115044247787611
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 1.27895986146634e-21 120 17 13 0.764705882352941 0.108333333333333
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 1.27895986146634e-21 120 17 13 0.764705882352941 0.108333333333333
REAC REAC:R-HSA-192823 Viral mRNA Translation 6.03878204544961e-21 90 17 12 0.705882352941177 0.133333333333333
REAC REAC:R-HSA-156902 Peptide chain elongation 6.03878204544961e-21 90 17 12 0.705882352941177 0.133333333333333
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 7.35706745606294e-21 94 17 12 0.705882352941177 0.127659574468085
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 7.35706745606294e-21 94 17 12 0.705882352941177 0.127659574468085
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 7.35706745606294e-21 94 17 12 0.705882352941177 0.127659574468085
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 8.74109920170692e-21 96 17 12 0.705882352941177 0.125
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 1.72834100021785e-20 102 17 12 0.705882352941177 0.117647058823529
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 5.50698668624597e-20 113 17 12 0.705882352941177 0.106194690265487
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 5.50698668624597e-20 171 17 13 0.764705882352941 0.0760233918128655
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 6.55867036545421e-20 116 17 12 0.705882352941177 0.103448275862069
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 6.55867036545421e-20 116 17 12 0.705882352941177 0.103448275862069
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 6.87529504899694e-20 117 17 12 0.705882352941177 0.102564102564103
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 3.22703989624665e-19 133 17 12 0.705882352941177 0.0902255639097744
REAC REAC:R-HSA-72766 Translation 3.8521116582788e-19 292 17 14 0.823529411764706 0.0479452054794521
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 9.28531984490092e-19 217 17 13 0.764705882352941 0.0599078341013825
REAC REAC:R-HSA-168255 Influenza Infection 1.45409513821657e-18 152 17 12 0.705882352941177 0.0789473684210526
REAC REAC:R-HSA-9711097 Cellular response to starvation 2.0721440822369e-18 157 17 12 0.705882352941177 0.0764331210191083
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 1.31187861600134e-17 183 17 12 0.705882352941177 0.0655737704918033
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 2.41665587903613e-17 193 17 12 0.705882352941177 0.0621761658031088
REAC REAC:R-HSA-72312 rRNA processing 4.30951831074587e-17 203 17 12 0.705882352941177 0.0591133004926108
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 5.6322560956329e-14 368 17 12 0.705882352941177 0.0326086956521739
REAC REAC:R-HSA-2262752 Cellular responses to stress 1.23477321166922e-13 546 17 13 0.764705882352941 0.0238095238095238
REAC REAC:R-HSA-422475 Axon guidance 1.27817803227475e-13 549 17 13 0.764705882352941 0.0236794171220401
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 1.59520834602968e-13 560 17 13 0.764705882352941 0.0232142857142857
REAC REAC:R-HSA-9675108 Nervous system development 2.12201573907855e-13 574 17 13 0.764705882352941 0.0226480836236934
REAC REAC:R-HSA-8953854 Metabolism of RNA 2.99782011901223e-12 658 21 14 0.666666666666667 0.0212765957446809
REAC REAC:R-HSA-5663205 Infectious disease 1.804427005825e-11 815 17 13 0.764705882352941 0.0159509202453988
REAC REAC:R-HSA-1266738 Developmental Biology 3.70707203643774e-10 1069 12 11 0.916666666666667 0.010289990645463
REAC REAC:R-HSA-392499 Metabolism of proteins 2.91657627208762e-09 1961 17 15 0.882352941176471 0.00764915859255482
REAC REAC:R-HSA-1643685 Disease 1.50709142457122e-08 1509 12 11 0.916666666666667 0.00728959575878065
REAC REAC:R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 1.93575217571952e-06 52 15 4 0.266666666666667 0.0769230769230769
REAC REAC:R-HSA-72649 Translation initiation complex formation 3.06497363931696e-06 59 15 4 0.266666666666667 0.0677966101694915
REAC REAC:R-HSA-72702 Ribosomal scanning and start codon recognition 3.06497363931696e-06 59 15 4 0.266666666666667 0.0677966101694915
REAC REAC:R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 3.19701955678767e-06 60 15 4 0.266666666666667 0.0666666666666667
REAC REAC:R-HSA-1430728 Metabolism 9.42725927832318e-06 2070 12 10 0.833333333333333 0.00483091787439614
TF TF:M00191 Factor: ER; motif: NNARGNCANNNTGACCYNN 0.0392403183197384 4848 13 11 0.846153846153846 0.00226897689768977
WP WP:WP477 Cytoplasmic Ribosomal Proteins 2.59994349614018e-19 90 17 12 0.705882352941177 0.133333333333333

pEpiTp05 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp05
Possible regulators of activation of pEpiTp05 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.