pEpiTp05 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).
Epithelial cell compositional overview
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.pEpiTp05 gene program activation among cells of different subtypes (Epithelial cells).
pEpiTp05 top program genes
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.
pEpiTp05 gene-set enrichment of top program genes (using g-profiler)
pEpiTp05 gene-set enrichment summary using g-profiler webtool.
Source
termID
Name
Padj
Tsize
Qsize
Overlap
Precision
Recall
CORUM
CORUM:306
Ribosome, cytoplasmic
1.09292984524712e-15
80
17
12
0.705882352941177
0.15
CORUM
CORUM:3055
Nop56p-associated pre-rRNA complex
2.60352815116075e-13
104
12
10
0.833333333333333
0.0961538461538462
CORUM
CORUM:308
60S ribosomal subunit, cytoplasmic
1.17397647145602e-12
47
17
9
0.529411764705882
0.191489361702128
CORUM
CORUM:5380
TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle)
3.34641516586003e-05
25
17
4
0.235294117647059
0.16
CORUM
CORUM:338
40S ribosomal subunit, cytoplasmic
0.000803210421271609
31
12
3
0.25
0.0967741935483871
CORUM
CORUM:305
40S ribosomal subunit, cytoplasmic
0.000809410877169821
33
12
3
0.25
0.0909090909090909
GO:BP
GO:0006614
SRP-dependent cotranslational protein targeting to membrane
5.94959093169247e-22
96
17
12
0.705882352941177
0.125
GO:BP
GO:0006613
cotranslational protein targeting to membrane
6.42380894147039e-22
102
17
12
0.705882352941177
0.117647058823529
GO:BP
GO:0045047
protein targeting to ER
1.56206908416883e-21
113
17
12
0.705882352941177
0.106194690265487
GO:BP
GO:0072599
establishment of protein localization to endoplasmic reticulum
pEpiTp05 transcription factor target enrichment of top program genes
Possible regulators of activation of pEpiTp05 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.
