pEpiTp11 program activity among Epithelial cells

Activation of pEpiTp11
pEpiTp11 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp11 by different cell subtypes
pEpiTp11 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp11 top program genes

Top genes of pEpiTp11 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp11 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp11
pEpiTp11 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0102664361509765 551 91 12 0.131868131868132 0.0217785843920145
GO:BP GO:0051641 cellular localization 0.0102664361509765 3541 53 24 0.452830188679245 0.00677774639932223
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0102664361509765 547 91 12 0.131868131868132 0.0219378427787934
GO:BP GO:0043299 leukocyte degranulation 0.0102664361509765 535 91 12 0.131868131868132 0.0224299065420561
GO:BP GO:0052548 regulation of endopeptidase activity 0.0102664361509765 437 106 12 0.113207547169811 0.0274599542334096
GO:BP GO:0052547 regulation of peptidase activity 0.0102664361509765 467 106 12 0.113207547169811 0.0256959314775161
GO:BP GO:0002283 neutrophil activation involved in immune response 0.012139138040692 485 91 11 0.120879120879121 0.022680412371134
GO:BP GO:0043312 neutrophil degranulation 0.012139138040692 482 91 11 0.120879120879121 0.0228215767634855
GO:BP GO:0042119 neutrophil activation 0.0123549348993175 498 91 11 0.120879120879121 0.0220883534136546
GO:BP GO:0002446 neutrophil mediated immunity 0.0123549348993175 497 91 11 0.120879120879121 0.0221327967806841
GO:BP GO:0036230 granulocyte activation 0.0125191519467069 504 91 11 0.120879120879121 0.0218253968253968
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.01312914097076 375 64 8 0.125 0.0213333333333333
GO:BP GO:0002443 leukocyte mediated immunity 0.0176062625023109 877 59 11 0.186440677966102 0.0125427594070696
GO:BP GO:0051649 establishment of localization in cell 0.0176062625023109 2813 71 24 0.338028169014085 0.00853181656594383
GO:BP GO:0072657 protein localization to membrane 0.0176062625023109 665 50 9 0.18 0.0135338345864662
GO:BP GO:0010038 response to metal ion 0.0176062625023109 371 13 4 0.307692307692308 0.0107816711590297
GO:BP GO:0045055 regulated exocytosis 0.0176062625023109 785 98 14 0.142857142857143 0.0178343949044586
GO:BP GO:0042127 regulation of cell population proliferation 0.0176062625023109 1774 128 27 0.2109375 0.0152198421645998
GO:BP GO:0002252 immune effector process 0.0176062625023109 1309 92 18 0.195652173913043 0.0137509549274255
GO:BP GO:0008637 apoptotic mitochondrial changes 0.0188794953467069 126 70 5 0.0714285714285714 0.0396825396825397
GO:BP GO:0002274 myeloid leukocyte activation 0.0188794953467069 667 91 12 0.131868131868132 0.0179910044977511
GO:BP GO:0060541 respiratory system development 0.0268309793662642 199 108 7 0.0648148148148148 0.0351758793969849
GO:BP GO:0097190 apoptotic signaling pathway 0.0268309793662642 600 91 11 0.120879120879121 0.0183333333333333
GO:BP GO:0006959 humoral immune response 0.0270125632360249 384 58 7 0.120689655172414 0.0182291666666667
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0291262382444222 717 91 12 0.131868131868132 0.0167364016736402
GO:BP GO:0002263 cell activation involved in immune response 0.0295118453093364 721 91 12 0.131868131868132 0.0166435506241331
GO:BP GO:0090343 positive regulation of cell aging 0.0356767289986715 23 108 3 0.0277777777777778 0.130434782608696
GO:BP GO:0048608 reproductive structure development 0.0356767289986715 429 113 10 0.0884955752212389 0.0233100233100233
GO:BP GO:0006887 exocytosis 0.0356767289986715 904 98 14 0.142857142857143 0.0154867256637168
GO:BP GO:0042129 regulation of T cell proliferation 0.0356767289986715 176 62 5 0.0806451612903226 0.0284090909090909
GO:BP GO:0061458 reproductive system development 0.0365118335443103 432 113 10 0.0884955752212389 0.0231481481481481
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.036666600648182 187 129 7 0.0542635658914729 0.0374331550802139
GO:BP GO:0016192 vesicle-mediated transport 0.0371791967844412 2180 59 17 0.288135593220339 0.00779816513761468
GO:BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0391449903485629 138 129 6 0.0465116279069767 0.0434782608695652
GO:BP GO:0009617 response to bacterium 0.0432691537801119 743 59 9 0.152542372881356 0.0121130551816958
GO:BP GO:0010952 positive regulation of peptidase activity 0.0432691537801119 205 129 7 0.0542635658914729 0.0341463414634146
GO:BP GO:0030323 respiratory tube development 0.0432691537801119 177 108 6 0.0555555555555556 0.0338983050847458
GO:BP GO:0001655 urogenital system development 0.0432691537801119 337 128 9 0.0703125 0.0267062314540059
GO:BP GO:0030324 lung development 0.0432691537801119 173 108 6 0.0555555555555556 0.0346820809248555
GO:BP GO:0042098 T cell proliferation 0.0432691537801119 205 62 5 0.0806451612903226 0.024390243902439
GO:BP GO:0010035 response to inorganic substance 0.0432691537801119 575 13 4 0.307692307692308 0.00695652173913044
GO:BP GO:0008283 cell population proliferation 0.0457558757600706 2054 132 28 0.212121212121212 0.0136319376825706
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.0457558757600706 1853 78 18 0.230769230769231 0.00971397733405289
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0457558757600706 445 62 7 0.112903225806452 0.0157303370786517
GO:BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.046915147233866 154 129 6 0.0465116279069767 0.038961038961039
GO:BP GO:0006810 transport 0.0483284090950194 5224 71 33 0.464788732394366 0.00631699846860643
GO:BP GO:0006886 intracellular protein transport 0.0483284090950194 1186 4 3 0.75 0.00252951096121417
GO:BP GO:0019730 antimicrobial humoral response 0.0483284090950194 145 26 3 0.115384615384615 0.0206896551724138
GO:BP GO:0001894 tissue homeostasis 0.0483284090950194 270 108 7 0.0648148148148148 0.0259259259259259
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 0.0483284090950194 446 9 3 0.333333333333333 0.00672645739910314
GO:BP GO:0030155 regulation of cell adhesion 0.0483284090950194 748 62 9 0.145161290322581 0.0120320855614973
GO:BP GO:0001836 release of cytochrome c from mitochondria 0.0483284090950194 59 63 3 0.0476190476190476 0.0508474576271186
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.0483284090950194 232 62 5 0.0806451612903226 0.021551724137931
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0483284090950194 217 129 7 0.0542635658914729 0.032258064516129
GO:BP GO:0046903 secretion 0.0483284090950194 1501 98 18 0.183673469387755 0.0119920053297801
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.0483284090950194 230 62 5 0.0806451612903226 0.0217391304347826
GO:BP GO:0051234 establishment of localization 0.0483284090950194 5372 71 34 0.47887323943662 0.00632911392405063
GO:BP GO:1903076 regulation of protein localization to plasma membrane 0.0483284090950194 105 35 3 0.0857142857142857 0.0285714285714286
GO:BP GO:0072659 protein localization to plasma membrane 0.0483284090950194 283 49 5 0.102040816326531 0.0176678445229682
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.0483284090950194 338 11 3 0.272727272727273 0.00887573964497041
GO:BP GO:0002376 immune system process 0.04844787377224 3278 14 8 0.571428571428571 0.0024405125076266
GO:BP GO:0051179 localization 0.0499788243483991 6901 73 41 0.561643835616438 0.00594116794667439
GO:CC GO:0005737 cytoplasm 0.000193821978583993 11911 73 65 0.89041095890411 0.0054571404583998
GO:CC GO:0005739 mitochondrion 0.00270759034001547 1673 89 21 0.235955056179775 0.0125523012552301
GO:CC GO:0005615 extracellular space 0.00270759034001547 3594 106 38 0.358490566037736 0.0105731775180857
GO:CC GO:0005576 extracellular region 0.00270759034001547 4567 111 47 0.423423423423423 0.0102912196190059
GO:CC GO:0030141 secretory granule 0.00270759034001547 851 98 15 0.153061224489796 0.0176263219741481
GO:CC GO:0031982 vesicle 0.00348552370659643 4055 107 41 0.383177570093458 0.0101109741060419
GO:CC GO:0012505 endomembrane system 0.0035141440713416 4640 117 48 0.41025641025641 0.0103448275862069
GO:CC GO:0099503 secretory vesicle 0.00353869925390164 1020 98 16 0.163265306122449 0.0156862745098039
GO:CC GO:0043227 membrane-bounded organelle 0.00588189735547418 12858 89 76 0.853932584269663 0.00591071706330689
GO:CC GO:0070820 tertiary granule 0.00588189735547418 163 91 6 0.0659340659340659 0.0368098159509202
GO:CC GO:0043226 organelle 0.00603842331646751 14008 89 80 0.898876404494382 0.00571102227298686
GO:CC GO:0031966 mitochondrial membrane 0.00808375670494546 746 43 8 0.186046511627907 0.0107238605898123
GO:CC GO:0031975 envelope 0.00808375670494546 1237 43 10 0.232558139534884 0.00808407437348424
GO:CC GO:0101002 ficolin-1-rich granule 0.00808375670494546 184 91 6 0.0659340659340659 0.0326086956521739
GO:CC GO:0031967 organelle envelope 0.00808375670494546 1237 43 10 0.232558139534884 0.00808407437348424
GO:CC GO:0005622 intracellular anatomical structure 0.00808375670494546 14790 89 82 0.921348314606742 0.00554428668018932
GO:CC GO:0005740 mitochondrial envelope 0.00808375670494546 797 43 8 0.186046511627907 0.0100376411543287
GO:CC GO:0031410 cytoplasmic vesicle 0.00911925322242299 2424 98 25 0.255102040816327 0.0103135313531353
GO:CC GO:0005840 ribosome 0.00911925322242299 245 50 5 0.1 0.0204081632653061
GO:CC GO:0097708 intracellular vesicle 0.00911925322242299 2428 98 25 0.255102040816327 0.0102965403624382
GO:CC GO:0043230 extracellular organelle 0.0110111718106222 2263 78 20 0.256410256410256 0.00883782589482987
GO:CC GO:1903561 extracellular vesicle 0.0110111718106222 2261 78 20 0.256410256410256 0.00884564352056612
GO:CC GO:0005761 mitochondrial ribosome 0.012408940424976 88 41 3 0.0731707317073171 0.0340909090909091
GO:CC GO:0000313 organellar ribosome 0.012408940424976 88 41 3 0.0731707317073171 0.0340909090909091
GO:CC GO:0034774 secretory granule lumen 0.012408940424976 320 91 7 0.0769230769230769 0.021875
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0125617416432687 324 91 7 0.0769230769230769 0.0216049382716049
GO:CC GO:0031983 vesicle lumen 0.0126362727562725 326 91 7 0.0769230769230769 0.0214723926380368
GO:CC GO:0070062 extracellular exosome 0.0133818845058153 2176 78 19 0.243589743589744 0.00873161764705882
GO:CC GO:0005783 endoplasmic reticulum 0.0168505680202594 1982 87 19 0.218390804597701 0.00958627648839556
GO:CC GO:0101003 ficolin-1-rich granule membrane 0.0170335236872933 60 71 3 0.0422535211267606 0.05
GO:CC GO:0044391 ribosomal subunit 0.0176325166314518 190 50 4 0.08 0.0210526315789474
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0217462877234116 11296 43 35 0.813953488372093 0.00309844192634561
GO:CC GO:1990904 ribonucleoprotein complex 0.0220588675878969 688 50 7 0.14 0.0101744186046512
GO:CC GO:0031225 anchored component of membrane 0.0281166519164514 174 106 5 0.0471698113207547 0.028735632183908
GO:CC GO:0043229 intracellular organelle 0.0281166519164514 12491 89 71 0.797752808988764 0.00568409254663358
GO:CC GO:0031090 organelle membrane 0.0303131571421361 3612 46 17 0.369565217391304 0.00470653377630122
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 0.0303768590834355 128 45 3 0.0666666666666667 0.0234375
GO:CC GO:0030667 secretory granule membrane 0.0387300825317652 303 98 6 0.0612244897959184 0.0198019801980198
GO:CC GO:0005743 mitochondrial inner membrane 0.0415186770710973 503 43 5 0.116279069767442 0.0099403578528827
GO:CC GO:1990234 transferase complex 0.043208089992541 804 65 8 0.123076923076923 0.00995024875621891
GO:CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 0.043208089992541 131 53 3 0.0566037735849057 0.0229007633587786
GO:CC GO:0005759 mitochondrial matrix 0.0492293908482705 479 89 7 0.0786516853932584 0.0146137787056367
GO:MF GO:0061134 peptidase regulator activity 0.0146126440043137 224 106 8 0.0754716981132075 0.0357142857142857
GO:MF GO:0042802 identical protein binding 0.0146126440043137 2067 129 30 0.232558139534884 0.0145137880986938
GO:MF GO:0003723 RNA binding 0.015231920922396 1943 10 6 0.6 0.00308800823468863
GO:MF GO:0003735 structural constituent of ribosome 0.015231920922396 171 50 5 0.1 0.0292397660818713
GO:MF GO:0004867 serine-type endopeptidase inhibitor activity 0.0171283701990213 98 106 5 0.0471698113207547 0.0510204081632653
GO:MF GO:0004857 enzyme inhibitor activity 0.0208645677161417 385 106 9 0.0849056603773585 0.0233766233766234
GO:MF GO:0061135 endopeptidase regulator activity 0.0208645677161417 188 106 6 0.0566037735849057 0.0319148936170213
GO:MF GO:0005198 structural molecule activity 0.0208645677161417 698 50 8 0.16 0.0114613180515759
GO:MF GO:0009055 electron transfer activity 0.0208645677161417 148 51 4 0.0784313725490196 0.027027027027027
GO:MF GO:0016504 peptidase activator activity 0.0234726386806606 42 91 3 0.032967032967033 0.0714285714285714
GO:MF GO:0005507 copper ion binding 0.0354520476355496 61 85 3 0.0352941176470588 0.0491803278688525
GO:MF GO:0004866 endopeptidase inhibitor activity 0.0385246519621288 176 106 5 0.0471698113207547 0.0284090909090909
GO:MF GO:0004175 endopeptidase activity 0.0394394197049522 450 105 8 0.0761904761904762 0.0177777777777778
GO:MF GO:0030414 peptidase inhibitor activity 0.0394394197049522 182 106 5 0.0471698113207547 0.0274725274725275
GO:MF GO:0004601 peroxidase activity 0.0407134335826525 53 117 3 0.0256410256410256 0.0566037735849057
GO:MF GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 0.0457789046293265 57 117 3 0.0256410256410256 0.0526315789473684
REAC REAC:R-HSA-196854 Metabolism of vitamins and cofactors 0.0383959148989154 186 92 7 0.0760869565217391 0.0376344086021505
REAC REAC:R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 0.0434505129550231 22 109 3 0.0275229357798165 0.136363636363636
TF TF:M01721 Factor: PUR1; motif: GGGNCAGNN 0.0190763661214673 9145 110 75 0.681818181818182 0.00820120284308365
TF TF:M08867_1 Factor: AP2; motif: GCCYGSGGSN; match class: 1 0.0205379186362715 5186 129 56 0.434108527131783 0.0107983031237948
TF TF:M08867 Factor: AP2; motif: GCCYGSGGSN 0.0205379186362715 10054 129 90 0.697674418604651 0.00895166103043565
TF TF:M04710_1 Factor: CHD2; motif: TCTCGCGAG; match class: 1 0.0205379186362715 11477 74 60 0.810810810810811 0.00522784699834452
TF TF:M09746_1 Factor: HNRPUL1; motif: NCNCAGN; match class: 1 0.0205379186362715 7619 56 37 0.660714285714286 0.0048562803517522
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0205379186362715 13929 130 112 0.861538461538462 0.00804077823246464
TF TF:M08877_1 Factor: EGR3; motif: NCMCRCCCACTNMN; match class: 1 0.0205379186362715 1397 132 24 0.181818181818182 0.0171796707229778
TF TF:M00915_1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 0.0205379186362715 4551 127 50 0.393700787401575 0.01098659635245
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.0205379186362715 4623 127 51 0.401574803149606 0.0110317975340688
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0217070589482865 16384 125 119 0.952 0.00726318359375
TF TF:M09723 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS 0.0217070589482865 10156 134 91 0.67910447761194 0.0089602205592753
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.0217070589482865 10357 124 86 0.693548387096774 0.00830356280776287
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0217070589482865 9106 125 79 0.632 0.00867559850647924
TF TF:M11842 Factor: ER-alpha; motif: NAGGTCAYSGYGACCTN 0.0217070589482865 4035 115 42 0.365217391304348 0.0104089219330855
TF TF:M07352 Factor: Crx; motif: NYTAATCNN 0.0217070589482865 1136 102 17 0.166666666666667 0.0149647887323944
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0217070589482865 13270 134 110 0.82089552238806 0.00828937452901281
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 0.0217070589482865 12351 134 105 0.783582089552239 0.00850133592421666
TF TF:M06948_1 Factor: Sp2; motif: TGGGCGCGCCCA; match class: 1 0.0217070589482865 6205 84 44 0.523809523809524 0.00709105560032232
TF TF:M08441_1 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 0.0217070589482865 12761 134 107 0.798507462686567 0.00838492281169187
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.0217070589482865 8180 128 75 0.5859375 0.00916870415647922
TF TF:M03876 Factor: Kaiso; motif: GCMGGGRGCRGS 0.0217070589482865 13622 125 105 0.84 0.00770811921891059
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0217070589482865 7728 120 68 0.566666666666667 0.0087991718426501
TF TF:M08441 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG 0.0217070589482865 16345 130 123 0.946153846153846 0.00752523707555827
TF TF:M01783 Factor: SP2; motif: GGGCGGGAC 0.0217070589482865 9148 86 58 0.674418604651163 0.00634018364669873
TF TF:M07395 Factor: Sp1; motif: NGGGGCGGGGN 0.0217070589482865 10640 121 86 0.710743801652893 0.00808270676691729
TF TF:M01857_1 Factor: AP-2alpha; motif: NGCCYSNNGSN; match class: 1 0.0217070589482865 4616 109 44 0.403669724770642 0.00953206239168111
TF TF:M00800_1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 0.0217070589482865 4268 129 48 0.372093023255814 0.0112464854732896
TF TF:M00979_1 Factor: Pax-6; motif: CTGACCTGGAACTM; match class: 1 0.0217070589482865 3068 9 7 0.777777777777778 0.00228161668839635
TF TF:M00333_1 Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 0.0217070589482865 12401 134 105 0.783582089552239 0.00846705910813644
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.0238102734592666 8944 120 75 0.625 0.00838550983899821
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.0256130527966863 15268 125 113 0.904 0.00740110034058161
TF TF:M00261_1 Factor: Olf-1; motif: NNCDABTCCCYAGRGARBNKGN; match class: 1 0.0268967763206179 726 106 13 0.122641509433962 0.0179063360881543
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.0268967763206179 14873 125 111 0.888 0.0074631883278424
TF TF:M03820 Factor: ER-alpha; motif: GGNNNNNNTGACCYN 0.0305135018901759 2765 8 6 0.75 0.00216998191681736
TF TF:M12183_1 Factor: KLF14; motif: NRCCACRCCCMCN; match class: 1 0.0305135018901759 2487 115 29 0.252173913043478 0.0116606353035786
TF TF:M09746 Factor: HNRPUL1; motif: NCNCAGN 0.0307346759663841 13720 84 73 0.869047619047619 0.00532069970845481
TF TF:M08208_1 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC; match class: 1 0.0327452346598715 7127 134 69 0.514925373134328 0.00968149291426968
TF TF:M07437 Factor: ZBTB2; motif: TCCKCCTSR 0.0348183182676195 3782 19 11 0.578947368421053 0.00290851401374934
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0358070001482585 9362 128 81 0.6328125 0.0086519974364452
TF TF:M08525 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM 0.0358070001482585 17065 130 125 0.961538461538462 0.00732493407559332
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0359272609585161 13611 112 94 0.839285714285714 0.0069061788259496
TF TF:M09774 Factor: KLF9; motif: NNCCACACCCACN 0.0361695345626767 801 129 15 0.116279069767442 0.0187265917602996
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.037063055032328 6334 112 54 0.482142857142857 0.00852541837701295
TF TF:M00428_1 Factor: E2F-1; motif: NKTSSCGC; match class: 1 0.037063055032328 3615 132 41 0.310606060606061 0.0113416320885201
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.037063055032328 13173 134 108 0.805970149253731 0.00819858802095195
TF TF:M08453 Factor: ERF:SREBP-2; motif: NSCGGAARTCACGTGAT 0.037063055032328 10112 30 25 0.833333333333333 0.00247231012658228
TF TF:M00982_1 Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 0.037063055032328 3518 110 35 0.318181818181818 0.0099488345650938
TF TF:M01220 Factor: STAT3:STAT3; motif: TTKMCGGGAAMTSC 0.037063055032328 1026 92 14 0.152173913043478 0.01364522417154
TF TF:M04148 Factor: TFAP2A; motif: NGCCCYNNGGGCN 0.0384038622935778 10040 130 86 0.661538461538462 0.00856573705179283
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0384038622935778 13190 134 108 0.805970149253731 0.00818802122820318
TF TF:M08523 Factor: E2F-1:TBR2; motif: NGGTGNNANGGCGCNNTNNCRNNN 0.0386733507634733 12160 130 99 0.761538461538461 0.00814144736842105
TF TF:M08208 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC 0.0386733507634733 12560 110 87 0.790909090909091 0.00692675159235669
TF TF:M09969 Factor: EKLF; motif: NGGGYGKGGCNNGG 0.0386733507634733 4589 127 47 0.37007874015748 0.0102418827631292
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.0386733507634733 10230 130 87 0.669230769230769 0.00850439882697947
TF TF:M02092_1 Factor: Egr-2; motif: CCCMCNCN; match class: 1 0.0386733507634733 905 59 10 0.169491525423729 0.0110497237569061
TF TF:M00333 Factor: ZF5; motif: NRNGNGCGCGCWN 0.0386733507634733 15072 125 111 0.888 0.00736464968152866
TF TF:M10121 Factor: ZFX; motif: SNAGGCCNCR 0.0386733507634733 3997 43 19 0.441860465116279 0.00475356517388041
TF TF:M11417 Factor: c-Ets-2; motif: NACCGGAAGYRCTTCCGGTN 0.0440563566671088 14334 125 107 0.856 0.00746476908050788
TF TF:M11032_1 Factor: Six-2; motif: NNGTAWCRNN; match class: 1 0.0440563566671088 4243 51 22 0.431372549019608 0.00518501060570351
TF TF:M00800 Factor: AP-2; motif: GSCCSCRGGCNRNRNN 0.0440563566671088 9119 129 79 0.612403100775194 0.00866323061739226
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.0466340908900303 3020 127 34 0.267716535433071 0.0112582781456954
TF TF:M10071 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG 0.0466340908900303 8495 134 77 0.574626865671642 0.00906415538552089
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0466340908900303 10233 121 81 0.669421487603306 0.0079155672823219
TF TF:M07322 Factor: HSF4; motif: CTGCMRN 0.0466340908900303 16573 101 96 0.95049504950495 0.00579255415434743
TF TF:M04863_1 Factor: TF3C-beta; motif: CCNGGAGGGCTTCCTGGAGGAG; match class: 1 0.0466340908900303 8573 125 73 0.584 0.00851510556397994
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.0466340908900303 10055 130 85 0.653846153846154 0.00845350571854799
TF TF:M11028_1 Factor: Six-1; motif: NCGTATCRNN; match class: 1 0.0466340908900303 161 84 5 0.0595238095238095 0.031055900621118
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0466340908900303 5262 127 51 0.401574803149606 0.0096921322690992
TF TF:M11796 Factor: NR1B1; motif: NRGGNCRTGACCTN 0.0466340908900303 10670 75 55 0.733333333333333 0.00515463917525773
TF TF:M09658_1 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS; match class: 1 0.0466340908900303 2033 127 26 0.204724409448819 0.0127889818002951
TF TF:M00450 Factor: Zic3; motif: NGGGKGGTC 0.0466340908900303 14000 79 69 0.873417721518987 0.00492857142857143
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.0466340908900303 7557 23 17 0.739130434782609 0.00224956993515945
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0466340908900303 8415 127 73 0.574803149606299 0.00867498514557338
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0466340908900303 6225 127 58 0.456692913385827 0.00931726907630522
TF TF:M09971 Factor: GKLF; motif: WGGGYGKGGC 0.0466340908900303 5546 112 48 0.428571428571429 0.00865488640461594
TF TF:M00322 Factor: c-Myc:Max; motif: GCCAYGYGSN 0.0466340908900303 7873 130 71 0.546153846153846 0.00901816334307126
TF TF:M00915 Factor: AP-2; motif: SNNNCCNCAGGCN 0.0466340908900303 9612 112 72 0.642857142857143 0.00749063670411985
TF TF:M00986 Factor: Churchill; motif: CGGGNN 0.0466340908900303 14197 130 110 0.846153846153846 0.00774811579911249
TF TF:M04710 Factor: CHD2; motif: TCTCGCGAG 0.0466340908900303 14109 43 40 0.930232558139535 0.00283506981359416
TF TF:M07251 Factor: EHF; motif: BTTCCTGC 0.0466340908900303 6174 89 43 0.48314606741573 0.00696469063816003
TF TF:M03896 Factor: EGR1; motif: NACGCCCACGCANW 0.0466340908900303 6129 123 56 0.455284552845528 0.00913689019415892
TF TF:M09973_1 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 0.0466340908900303 6607 128 61 0.4765625 0.00923263205690934
TF TF:M10898 Factor: Otx2; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M10916 Factor: pitx1; motif: CTAATCCC 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M09764 Factor: ROX; motif: GNNNCASGTGGS 0.0466485585752064 5809 125 54 0.432 0.0092959201239456
TF TF:M10908 Factor: Pitx3; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M10960 Factor: PEPP-2; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M10961 Factor: PEPP-2; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M12151_1 Factor: Sp1; motif: NWRGCCMCGCCCMCN; match class: 1 0.0466485585752064 2548 127 30 0.236220472440945 0.0117739403453689
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0466485585752064 6260 127 58 0.456692913385827 0.00926517571884984
TF TF:M10899 Factor: Otx1; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M10917 Factor: pitx1; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M10897 Factor: Otx2; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M01703 Factor: Gli2; motif: GACCACCCANG 0.0466485585752064 3764 129 40 0.310077519379845 0.0106269925611052
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.0466485585752064 7508 128 67 0.5234375 0.00892381459776239
TF TF:M10903 Factor: Crx; motif: NTAATCCN 0.0466485585752064 904 102 13 0.127450980392157 0.0143805309734513
TF TF:M12139 Factor: Egr-1; motif: NMCRCCCMCNCNN 0.0466485585752064 3773 66 24 0.363636363636364 0.00636098595282269
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.0466485585752064 14473 130 111 0.853846153846154 0.00766945346507289
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.0466485585752064 16194 130 120 0.923076923076923 0.00741015190811412
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.0466485585752064 3962 134 43 0.32089552238806 0.0108531044926805
TF TF:M10921 Factor: Gsc; motif: NTAATCCN 0.0466485585752064 1479 131 21 0.16030534351145 0.0141987829614604
TF TF:M04823 Factor: E2F-4; motif: NNTTCCCGCCNN 0.0467320434316661 12747 134 104 0.776119402985075 0.00815878245861771
TF TF:M09765_1 Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 0.0467320434316661 3318 127 36 0.283464566929134 0.0108499095840868
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.0481269523815811 10853 121 84 0.694214876033058 0.00773979544826315
TF TF:M00246 Factor: Egr-2; motif: NTGCGTRGGCGK 0.0494280407575176 6212 55 29 0.527272727272727 0.00466838377334192
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.0495426481053077 11467 128 92 0.71875 0.00802302258655272

pEpiTp11 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp11
Possible regulators of activation of pEpiTp11 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.