pTNI21 program activity among T/NK/ILC cells

Activation of pTNI21
pTNI21 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI21 by different cell subtypes
pTNI21 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI21 top program genes

Top genes of pTNI21 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI21 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI21
pTNI21 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002521 leukocyte differentiation 2.28110899845534e-07 550 96 19 0.197916666666667 0.0345454545454545
GO:BP GO:1903131 mononuclear cell differentiation 1.49130917329056e-06 430 96 16 0.166666666666667 0.0372093023255814
GO:BP GO:0071345 cellular response to cytokine stimulus 3.46286196537391e-06 1132 38 15 0.394736842105263 0.0132508833922261
GO:BP GO:0019221 cytokine-mediated signaling pathway 4.13817806227506e-06 810 38 13 0.342105263157895 0.0160493827160494
GO:BP GO:0034097 response to cytokine 6.15050162390658e-06 1226 38 15 0.394736842105263 0.0122349102773246
GO:BP GO:0002682 regulation of immune system process 1.21281006171572e-05 1617 93 27 0.290322580645161 0.0166975881261596
GO:BP GO:0048534 hematopoietic or lymphoid organ development 1.21412864498985e-05 966 96 21 0.21875 0.0217391304347826
GO:BP GO:0071310 cellular response to organic substance 1.46464983908883e-05 2776 97 37 0.381443298969072 0.013328530259366
GO:BP GO:0032922 circadian regulation of gene expression 1.73471186473528e-05 67 92 7 0.0760869565217391 0.104477611940299
GO:BP GO:0030097 hemopoiesis 2.03543369765828e-05 928 96 20 0.208333333333333 0.021551724137931
GO:BP GO:0002520 immune system development 2.03543369765828e-05 1020 96 21 0.21875 0.0205882352941176
GO:BP GO:0030098 lymphocyte differentiation 2.54884782385956e-05 376 96 13 0.135416666666667 0.0345744680851064
GO:BP GO:0046649 lymphocyte activation 2.65791630980153e-05 771 96 18 0.1875 0.0233463035019455
GO:BP GO:0007623 circadian rhythm 3.65940466495004e-05 219 92 10 0.108695652173913 0.045662100456621
GO:BP GO:0001775 cell activation 3.65940466495004e-05 1495 96 25 0.260416666666667 0.0167224080267559
GO:BP GO:0006955 immune response 3.73238572672631e-05 2311 38 18 0.473684210526316 0.00778883600173085
GO:BP GO:0002376 immune system process 3.73238572672631e-05 3278 96 39 0.40625 0.0118974984746797
GO:BP GO:0042752 regulation of circadian rhythm 3.73238572672631e-05 122 92 8 0.0869565217391304 0.0655737704918033
GO:BP GO:0010033 response to organic substance 4.65271919341081e-05 3412 97 40 0.412371134020619 0.0117233294255569
GO:BP GO:0045321 leukocyte activation 5.29424432661928e-05 1332 103 24 0.233009708737864 0.018018018018018
GO:BP GO:0051239 regulation of multicellular organismal process 5.55260748076747e-05 2861 98 36 0.36734693877551 0.0125830129325411
GO:BP GO:0051240 positive regulation of multicellular organismal process 8.94280346386383e-05 1455 72 20 0.277777777777778 0.013745704467354
GO:BP GO:0070887 cellular response to chemical stimulus 0.000101306726125811 3393 97 39 0.402061855670103 0.0114942528735632
GO:BP GO:0002573 myeloid leukocyte differentiation 0.000128645375975398 213 88 9 0.102272727272727 0.0422535211267606
GO:BP GO:0002250 adaptive immune response 0.000142149916442496 689 38 10 0.263157894736842 0.0145137880986938
GO:BP GO:0010628 positive regulation of gene expression 0.00017997814694868 1160 70 17 0.242857142857143 0.0146551724137931
GO:BP GO:0006954 inflammatory response 0.00027368442411664 794 92 16 0.173913043478261 0.0201511335012594
GO:BP GO:0045639 positive regulation of myeloid cell differentiation 0.000368184959741745 103 71 6 0.0845070422535211 0.058252427184466
GO:BP GO:0002763 positive regulation of myeloid leukocyte differentiation 0.000372036766872819 59 71 5 0.0704225352112676 0.0847457627118644
GO:BP GO:0048511 rhythmic process 0.000372036766872819 307 92 10 0.108695652173913 0.0325732899022801
GO:BP GO:0045672 positive regulation of osteoclast differentiation 0.000372036766872819 27 71 4 0.0563380281690141 0.148148148148148
GO:BP GO:0001819 positive regulation of cytokine production 0.000372036766872819 452 38 8 0.210526315789474 0.0176991150442478
GO:BP GO:0007166 cell surface receptor signaling pathway 0.000413351782179652 3210 71 29 0.408450704225352 0.00903426791277259
GO:BP GO:0097398 cellular response to interleukin-17 0.00041952064527205 11 56 3 0.0535714285714286 0.272727272727273
GO:BP GO:0097400 interleukin-17-mediated signaling pathway 0.00041952064527205 11 56 3 0.0535714285714286 0.272727272727273
GO:BP GO:0097396 response to interleukin-17 0.00041952064527205 11 56 3 0.0535714285714286 0.272727272727273
GO:BP GO:0030217 T cell differentiation 0.00063650793496464 260 70 8 0.114285714285714 0.0307692307692308
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00064081038854692 363 37 7 0.189189189189189 0.0192837465564738
GO:BP GO:2000026 regulation of multicellular organismal development 0.00064081038854692 1447 98 22 0.224489795918367 0.0152038700760194
GO:BP GO:0042753 positive regulation of circadian rhythm 0.000738841079665212 17 44 3 0.0681818181818182 0.176470588235294
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.000765610992716911 190 71 7 0.0985915492957746 0.0368421052631579
GO:BP GO:0042113 B cell activation 0.000766279910265348 330 96 10 0.104166666666667 0.0303030303030303
GO:BP GO:0031638 zymogen activation 0.000766279910265348 58 42 4 0.0952380952380952 0.0689655172413793
GO:BP GO:0072539 T-helper 17 cell differentiation 0.00083316810067562 29 28 3 0.107142857142857 0.103448275862069
GO:BP GO:0042110 T cell activation 0.00083316810067562 489 41 8 0.195121951219512 0.016359918200409
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.000917640660962333 306 65 8 0.123076923076923 0.0261437908496732
GO:BP GO:0033993 response to lipid 0.00112247083194365 918 114 18 0.157894736842105 0.0196078431372549
GO:BP GO:0072538 T-helper 17 type immune response 0.00116457765951784 33 28 3 0.107142857142857 0.0909090909090909
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00130046905925511 717 71 12 0.169014084507042 0.0167364016736402
GO:BP GO:0048513 animal organ development 0.00130046905925511 3672 71 30 0.422535211267606 0.00816993464052288
GO:BP GO:0034612 response to tumor necrosis factor 0.00131577401873647 331 10 4 0.4 0.0120845921450151
GO:BP GO:0002263 cell activation involved in immune response 0.00131577401873647 721 71 12 0.169014084507042 0.0166435506241331
GO:BP GO:0050793 regulation of developmental process 0.00135819160347747 2605 125 36 0.288 0.0138195777351248
GO:BP GO:0045598 regulation of fat cell differentiation 0.00148169665522857 139 112 7 0.0625 0.0503597122302158
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.001793007961188 329 21 5 0.238095238095238 0.0151975683890578
GO:BP GO:0071320 cellular response to cAMP 0.00180891820733074 54 21 3 0.142857142857143 0.0555555555555556
GO:BP GO:0071347 cellular response to interleukin-1 0.00197462042957424 185 7 3 0.428571428571429 0.0162162162162162
GO:BP GO:0001944 vasculature development 0.00203692879359296 830 98 15 0.153061224489796 0.0180722891566265
GO:BP GO:0048584 positive regulation of response to stimulus 0.00203692879359296 2344 38 15 0.394736842105263 0.00639931740614334
GO:BP GO:0048731 system development 0.00203710931061785 5052 114 52 0.456140350877193 0.0102929532858274
GO:BP GO:0030099 myeloid cell differentiation 0.0021859515008356 428 88 10 0.113636363636364 0.0233644859813084
GO:BP GO:0045595 regulation of cell differentiation 0.00219654401092096 1679 122 26 0.213114754098361 0.015485407980941
GO:BP GO:0002684 positive regulation of immune system process 0.00224994671835876 1065 53 12 0.226415094339623 0.0112676056338028
GO:BP GO:0048518 positive regulation of biological process 0.00232417217742436 6363 72 42 0.583333333333333 0.0066006600660066
GO:BP GO:0002252 immune effector process 0.00250657019173196 1309 73 16 0.219178082191781 0.0122230710466005
GO:BP GO:0070555 response to interleukin-1 0.00264945135681301 215 7 3 0.428571428571429 0.013953488372093
GO:BP GO:0042221 response to chemical 0.00319192466603908 4781 116 50 0.431034482758621 0.0104580631667015
GO:BP GO:1904894 positive regulation of receptor signaling pathway via STAT 0.00354437923098612 50 85 4 0.0470588235294118 0.08
GO:BP GO:0048583 regulation of response to stimulus 0.00354437923098612 4278 46 23 0.5 0.00537634408602151
GO:BP GO:0007165 signal transduction 0.00354437923098612 6309 46 29 0.630434782608696 0.00459660802028848
GO:BP GO:0001568 blood vessel development 0.00354437923098612 792 98 14 0.142857142857143 0.0176767676767677
GO:BP GO:0042592 homeostatic process 0.00354437923098612 1981 102 25 0.245098039215686 0.0126198889449773
GO:BP GO:0045444 fat cell differentiation 0.00354437923098612 229 112 8 0.0714285714285714 0.0349344978165939
GO:BP GO:0032735 positive regulation of interleukin-12 production 0.00354437923098612 41 37 3 0.0810810810810811 0.0731707317073171
GO:BP GO:0001890 placenta development 0.00354437923098612 147 88 6 0.0681818181818182 0.0408163265306122
GO:BP GO:0030522 intracellular receptor signaling pathway 0.00385830743790413 284 92 8 0.0869565217391304 0.028169014084507
GO:BP GO:0030183 B cell differentiation 0.0038800581327453 140 96 6 0.0625 0.0428571428571429
GO:BP GO:0050865 regulation of cell activation 0.00417338804460487 655 78 11 0.141025641025641 0.016793893129771
GO:BP GO:0048514 blood vessel morphogenesis 0.00441663348856336 711 98 13 0.13265306122449 0.0182841068917018
GO:BP GO:0002761 regulation of myeloid leukocyte differentiation 0.00452669596905987 123 71 5 0.0704225352112676 0.040650406504065
GO:BP GO:0023052 signaling 0.00457771888111208 6810 42 28 0.666666666666667 0.00411160058737151
GO:BP GO:0009653 anatomical structure morphogenesis 0.00457771888111208 2797 72 24 0.333333333333333 0.00858062209510189
GO:BP GO:0007154 cell communication 0.00469950565114636 6829 42 28 0.666666666666667 0.00410016107775663
GO:BP GO:0045670 regulation of osteoclast differentiation 0.00469950565114636 66 71 4 0.0563380281690141 0.0606060606060606
GO:BP GO:1902105 regulation of leukocyte differentiation 0.00471098459625387 288 71 7 0.0985915492957746 0.0243055555555556
GO:BP GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 0.00490406909455768 52 92 4 0.0434782608695652 0.0769230769230769
GO:BP GO:0042093 T-helper cell differentiation 0.00491647396259698 66 28 3 0.107142857142857 0.0454545454545455
GO:BP GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 0.00521053225224914 68 28 3 0.107142857142857 0.0441176470588235
GO:BP GO:0002293 alpha-beta T cell differentiation involved in immune response 0.00526654923945853 69 28 3 0.107142857142857 0.0434782608695652
GO:BP GO:0002287 alpha-beta T cell activation involved in immune response 0.00526654923945853 69 28 3 0.107142857142857 0.0434782608695652
GO:BP GO:0048878 chemical homeostasis 0.00526654923945853 1229 102 18 0.176470588235294 0.0146460537021969
GO:BP GO:0097067 cellular response to thyroid hormone stimulus 0.00526654923945853 17 116 3 0.0258620689655172 0.176470588235294
GO:BP GO:0050776 regulation of immune response 0.00536045219270555 996 23 7 0.304347826086957 0.0070281124497992
GO:BP GO:0035239 tube morphogenesis 0.00544986426084096 950 98 15 0.153061224489796 0.0157894736842105
GO:BP GO:0051591 response to cAMP 0.00574200896805345 97 21 3 0.142857142857143 0.0309278350515464
GO:BP GO:0030101 natural killer cell activation 0.00574200896805345 84 61 4 0.0655737704918033 0.0476190476190476
GO:BP GO:0002292 T cell differentiation involved in immune response 0.00621640929878258 75 28 3 0.107142857142857 0.04
GO:BP GO:0045165 cell fate commitment 0.00621640929878258 267 82 7 0.0853658536585366 0.0262172284644195
GO:BP GO:0051094 positive regulation of developmental process 0.00627937956246189 1341 72 15 0.208333333333333 0.0111856823266219
GO:BP GO:1903706 regulation of hemopoiesis 0.00633940686808344 424 88 9 0.102272727272727 0.0212264150943396
GO:BP GO:0001817 regulation of cytokine production 0.00633940686808344 806 38 8 0.210526315789474 0.00992555831265509
GO:BP GO:0032814 regulation of natural killer cell activation 0.00633940686808344 35 61 3 0.0491803278688525 0.0857142857142857
GO:BP GO:0048699 generation of neurons 0.00662832223362583 1559 121 23 0.190082644628099 0.0147530468248877
GO:BP GO:0009887 animal organ morphogenesis 0.00672431793555736 1073 71 13 0.183098591549296 0.0121155638397018
GO:BP GO:0032655 regulation of interleukin-12 production 0.006815545248509 60 37 3 0.0810810810810811 0.05
GO:BP GO:0032615 interleukin-12 production 0.006815545248509 60 37 3 0.0810810810810811 0.05
GO:BP GO:0002694 regulation of leukocyte activation 0.00713472659068984 610 92 11 0.119565217391304 0.0180327868852459
GO:BP GO:0048856 anatomical structure development 0.00747521091403809 6106 72 39 0.541666666666667 0.00638716017032427
GO:BP GO:0048017 inositol lipid-mediated signaling 0.00750312909690415 201 114 7 0.0614035087719298 0.0348258706467662
GO:BP GO:0016485 protein processing 0.00750312909690415 235 45 5 0.111111111111111 0.0212765957446809
GO:BP GO:0030154 cell differentiation 0.00752882354867252 4350 72 31 0.430555555555556 0.0071264367816092
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.00767309985881102 263 88 7 0.0795454545454545 0.026615969581749
GO:BP GO:0043367 CD4-positive, alpha-beta T cell differentiation 0.00773409680199337 85 28 3 0.107142857142857 0.0352941176470588
GO:BP GO:0071407 cellular response to organic cyclic compound 0.00773409680199337 587 97 11 0.11340206185567 0.0187393526405451
GO:BP GO:0001816 cytokine production 0.00773409680199337 844 38 8 0.210526315789474 0.00947867298578199
GO:BP GO:0036315 cellular response to sterol 0.00798559365814011 25 97 3 0.0309278350515464 0.12
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00815653116040214 3483 45 19 0.422222222222222 0.00545506747057135
GO:BP GO:0008283 cell population proliferation 0.00815653116040214 2054 26 10 0.384615384615385 0.00486854917234664
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.00815653116040214 107 23 3 0.130434782608696 0.0280373831775701
GO:BP GO:0007275 multicellular organism development 0.00863392928506382 5613 114 53 0.464912280701754 0.00944236593621949
GO:BP GO:0051249 regulation of lymphocyte activation 0.00896204559958825 518 78 9 0.115384615384615 0.0173745173745174
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.00896204559958825 157 71 5 0.0704225352112676 0.0318471337579618
GO:BP GO:1903708 positive regulation of hemopoiesis 0.00896204559958825 157 71 5 0.0704225352112676 0.0318471337579618
GO:BP GO:0048869 cellular developmental process 0.00933123318513859 4428 72 31 0.430555555555556 0.00700090334236676
GO:BP GO:0035295 tube development 0.00957210150160242 1146 98 16 0.163265306122449 0.0139616055846422
GO:BP GO:0046632 alpha-beta T cell differentiation 0.00981521147251308 113 57 4 0.0701754385964912 0.0353982300884956
GO:BP GO:1901700 response to oxygen-containing compound 0.0100847496840653 1739 114 23 0.201754385964912 0.0132259919493962
GO:BP GO:0033619 membrane protein proteolysis 0.0102089058030287 61 45 3 0.0666666666666667 0.0491803278688525
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.0102341614102218 230 78 6 0.0769230769230769 0.0260869565217391
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.0106235719944717 232 78 6 0.0769230769230769 0.0258620689655172
GO:BP GO:0070661 leukocyte proliferation 0.0106235719944717 325 78 7 0.0897435897435897 0.0215384615384615
GO:BP GO:0042127 regulation of cell population proliferation 0.0106235719944717 1774 92 20 0.217391304347826 0.0112739571589628
GO:BP GO:0046683 response to organophosphorus 0.0107318608324377 137 21 3 0.142857142857143 0.0218978102189781
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0109409171979294 3083 44 17 0.386363636363636 0.00551410963347389
GO:BP GO:0019218 regulation of steroid metabolic process 0.0109409171979294 130 92 5 0.0543478260869565 0.0384615384615385
GO:BP GO:0050673 epithelial cell proliferation 0.0110918392058404 460 92 9 0.0978260869565217 0.0195652173913043
GO:BP GO:0014065 phosphatidylinositol 3-kinase signaling 0.0110918392058404 161 114 6 0.0526315789473684 0.0372670807453416
GO:BP GO:0035710 CD4-positive, alpha-beta T cell activation 0.0110918392058404 104 28 3 0.107142857142857 0.0288461538461538
GO:BP GO:0006367 transcription initiation from RNA polymerase II promoter 0.0110918392058404 200 92 6 0.0652173913043478 0.03
GO:BP GO:0042476 odontogenesis 0.0113903255530054 130 53 4 0.0754716981132075 0.0307692307692308
GO:BP GO:0006950 response to stress 0.0113903255530054 4170 97 37 0.381443298969072 0.00887290167865707
GO:BP GO:0030316 osteoclast differentiation 0.0118166282198801 98 71 4 0.0563380281690141 0.0408163265306122
GO:BP GO:0048522 positive regulation of cellular process 0.0118280230028464 5757 49 27 0.551020408163265 0.00468994267847837
GO:BP GO:0097066 response to thyroid hormone 0.0118280230028464 26 116 3 0.0258620689655172 0.115384615384615
GO:BP GO:0014070 response to organic cyclic compound 0.0118433660365229 967 108 15 0.138888888888889 0.015511892450879
GO:BP GO:0014074 response to purine-containing compound 0.0120890443724476 152 82 5 0.0609756097560976 0.0328947368421053
GO:BP GO:0002440 production of molecular mediator of immune response 0.0121736607247768 189 38 4 0.105263157894737 0.0211640211640212
GO:BP GO:0072359 circulatory system development 0.0121736607247768 1194 98 16 0.163265306122449 0.0134003350083752
GO:BP GO:0032526 response to retinoic acid 0.0122310344118265 110 114 5 0.043859649122807 0.0454545454545455
GO:BP GO:0022008 neurogenesis 0.0122310344118265 1675 121 23 0.190082644628099 0.0137313432835821
GO:BP GO:0010743 regulation of macrophage derived foam cell differentiation 0.0122656202112191 32 97 3 0.0309278350515464 0.09375
GO:BP GO:0071495 cellular response to endogenous stimulus 0.0123090320864376 1422 116 20 0.172413793103448 0.0140646976090014
GO:BP GO:0002286 T cell activation involved in immune response 0.0123850951803962 112 28 3 0.107142857142857 0.0267857142857143
GO:BP GO:0035556 intracellular signal transduction 0.0127179904443413 2772 37 14 0.378378378378378 0.00505050505050505
GO:BP GO:0021953 central nervous system neuron differentiation 0.0127489274233321 188 68 5 0.0735294117647059 0.0265957446808511
GO:BP GO:0009966 regulation of signal transduction 0.0129373510592233 3165 92 29 0.315217391304348 0.00916271721958926
GO:BP GO:0002449 lymphocyte mediated immunity 0.012993412193234 354 37 5 0.135135135135135 0.0141242937853107
GO:BP GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 0.0132336044799935 46 70 3 0.0428571428571429 0.0652173913043478
GO:BP GO:0070663 regulation of leukocyte proliferation 0.0132336044799935 251 78 6 0.0769230769230769 0.0239043824701195
GO:BP GO:0032502 developmental process 0.013734812842731 6628 72 40 0.555555555555556 0.00603500301750151
GO:BP GO:0006952 defense response 0.013734812842731 1818 93 20 0.21505376344086 0.011001100110011
GO:BP GO:0030855 epithelial cell differentiation 0.013854071863786 798 57 9 0.157894736842105 0.0112781954887218
GO:BP GO:0030224 monocyte differentiation 0.0139641662283215 38 88 3 0.0340909090909091 0.0789473684210526
GO:BP GO:0050829 defense response to Gram-negative bacterium 0.0139641662283215 88 38 3 0.0789473684210526 0.0340909090909091
GO:BP GO:0042100 B cell proliferation 0.0141440679546173 98 78 4 0.0512820512820513 0.0408163265306122
GO:BP GO:0036314 response to sterol 0.0143183656670325 35 97 3 0.0309278350515464 0.0857142857142857
GO:BP GO:0032870 cellular response to hormone stimulus 0.0145022054255377 645 116 12 0.103448275862069 0.0186046511627907
GO:BP GO:0045597 positive regulation of cell differentiation 0.0146038334286509 879 98 13 0.13265306122449 0.0147895335608646
GO:BP GO:0042759 long-chain fatty acid biosynthetic process 0.0147075739564815 32 108 3 0.0277777777777778 0.09375
GO:BP GO:0009719 response to endogenous stimulus 0.0150604738813974 1683 116 22 0.189655172413793 0.0130718954248366
GO:BP GO:0051604 protein maturation 0.0151081460309991 306 45 5 0.111111111111111 0.0163398692810458
GO:BP GO:0009893 positive regulation of metabolic process 0.0155323148139274 3783 45 19 0.422222222222222 0.00502246893999471
GO:BP GO:0002699 positive regulation of immune effector process 0.0155323148139274 215 64 5 0.078125 0.0232558139534884
GO:BP GO:0090077 foam cell differentiation 0.0159878310691624 37 97 3 0.0309278350515464 0.0810810810810811
GO:BP GO:0010742 macrophage derived foam cell differentiation 0.0159878310691624 37 97 3 0.0309278350515464 0.0810810810810811
GO:BP GO:0034405 response to fluid shear stress 0.0159878310691624 37 97 3 0.0309278350515464 0.0810810810810811
GO:BP GO:0071396 cellular response to lipid 0.0163957748811124 578 114 11 0.0964912280701754 0.0190311418685121
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.0166095809436144 3274 44 17 0.386363636363636 0.00519242516799023
GO:BP GO:0002697 regulation of immune effector process 0.0178374608393595 461 64 7 0.109375 0.0151843817787419
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0180137768954507 539 71 8 0.112676056338028 0.0148423005565863
GO:BP GO:0048568 embryonic organ development 0.0180137768954507 432 88 8 0.0909090909090909 0.0185185185185185
GO:BP GO:0042102 positive regulation of T cell proliferation 0.0185393700024213 104 37 3 0.0810810810810811 0.0288461538461538
GO:BP GO:0051716 cellular response to stimulus 0.0195785090580932 7781 38 26 0.684210526315789 0.0033414728184038
GO:BP GO:1901135 carbohydrate derivative metabolic process 0.0196011298244008 1145 70 12 0.171428571428571 0.0104803493449782
GO:BP GO:0001906 cell killing 0.0197043898074091 175 23 3 0.130434782608696 0.0171428571428571
GO:BP GO:0046631 alpha-beta T cell activation 0.0199955519250395 155 57 4 0.0701754385964912 0.0258064516129032
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0200789144327243 982 71 11 0.154929577464789 0.0112016293279022
GO:BP GO:0048015 phosphatidylinositol-mediated signaling 0.0209985412717397 197 114 6 0.0526315789473684 0.0304568527918782
GO:BP GO:0002443 leukocyte mediated immunity 0.0211252292206985 877 27 6 0.222222222222222 0.00684150513112885
GO:BP GO:0060191 regulation of lipase activity 0.0216267276058017 101 90 4 0.0444444444444444 0.0396039603960396
GO:BP GO:0097028 dendritic cell differentiation 0.0218724905243937 48 88 3 0.0340909090909091 0.0625
GO:BP GO:0002064 epithelial cell development 0.0218815792586329 218 71 5 0.0704225352112676 0.0229357798165138
GO:BP GO:0010646 regulation of cell communication 0.0219665236601037 3543 46 18 0.391304347826087 0.00508044030482642
GO:BP GO:0046651 lymphocyte proliferation 0.0219665236601037 294 78 6 0.0769230769230769 0.0204081632653061
GO:BP GO:0032943 mononuclear cell proliferation 0.0221953528480025 297 78 6 0.0769230769230769 0.0202020202020202
GO:BP GO:0019439 aromatic compound catabolic process 0.0221953528480025 623 26 5 0.192307692307692 0.00802568218298555
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0221953528480025 1842 46 12 0.260869565217391 0.00651465798045603
GO:BP GO:0000165 MAPK cascade 0.0221953528480025 935 26 6 0.230769230769231 0.00641711229946524
GO:BP GO:0062012 regulation of small molecule metabolic process 0.0228547051466762 447 112 9 0.0803571428571429 0.0201342281879195
GO:BP GO:0001525 angiogenesis 0.0229985450534375 617 98 10 0.102040816326531 0.0162074554294976
GO:BP GO:0048512 circadian behavior 0.0229985450534375 48 92 3 0.0326086956521739 0.0625
GO:BP GO:0042475 odontogenesis of dentin-containing tooth 0.0229985450534375 90 49 3 0.0612244897959184 0.0333333333333333
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.0230877352789281 215 21 3 0.142857142857143 0.013953488372093
GO:BP GO:0023051 regulation of signaling 0.0231202180862831 3578 46 18 0.391304347826087 0.00503074343208496
GO:BP GO:0007622 rhythmic behavior 0.0237625685285726 49 92 3 0.0326086956521739 0.0612244897959184
GO:BP GO:0042632 cholesterol homeostasis 0.0237625685285726 99 97 4 0.0412371134020619 0.0404040404040404
GO:BP GO:0019915 lipid storage 0.0237625685285726 86 112 4 0.0357142857142857 0.0465116279069767
GO:BP GO:0055092 sterol homeostasis 0.0239724505454341 100 97 4 0.0412371134020619 0.04
GO:BP GO:0055088 lipid homeostasis 0.0239724505454341 167 97 5 0.0515463917525773 0.029940119760479
GO:BP GO:0097696 receptor signaling pathway via STAT 0.0239724505454341 184 88 5 0.0568181818181818 0.0271739130434783
GO:BP GO:1901361 organic cyclic compound catabolic process 0.0242074409736478 651 26 5 0.192307692307692 0.00768049155145929
GO:BP GO:0061061 muscle structure development 0.025079710389012 645 8 3 0.375 0.00465116279069767
GO:BP GO:0050778 positive regulation of immune response 0.025079710389012 753 23 5 0.217391304347826 0.00664010624169987
GO:BP GO:0006352 DNA-templated transcription, initiation 0.025079710389012 262 92 6 0.0652173913043478 0.0229007633587786
GO:BP GO:0050896 response to stimulus 0.0251315010144891 9407 106 70 0.660377358490566 0.00744126714149038
GO:BP GO:0051403 stress-activated MAPK cascade 0.0251315010144891 272 37 4 0.108108108108108 0.0147058823529412
GO:BP GO:0006687 glycosphingolipid metabolic process 0.0258002764539825 68 70 3 0.0428571428571429 0.0441176470588235
GO:BP GO:1904892 regulation of receptor signaling pathway via STAT 0.0258002764539825 118 85 4 0.0470588235294118 0.0338983050847458
GO:BP GO:0009791 post-embryonic development 0.0260724602627282 84 57 3 0.0526315789473684 0.0357142857142857
GO:BP GO:0044262 cellular carbohydrate metabolic process 0.026908777903932 296 112 7 0.0625 0.0236486486486486
GO:BP GO:0003279 cardiac septum development 0.026908777903932 104 98 4 0.0408163265306122 0.0384615384615385
GO:BP GO:0042742 defense response to bacterium 0.026908777903932 349 71 6 0.0845070422535211 0.0171919770773639
GO:BP GO:0030888 regulation of B cell proliferation 0.0276454587570363 63 78 3 0.0384615384615385 0.0476190476190476
GO:BP GO:0009605 response to external stimulus 0.027700003862316 2944 125 33 0.264 0.0112092391304348
GO:BP GO:0030182 neuron differentiation 0.027700003862316 1412 121 19 0.15702479338843 0.0134560906515581
GO:BP GO:0031098 stress-activated protein kinase signaling cascade 0.0289859438301747 288 37 4 0.108108108108108 0.0138888888888889
GO:BP GO:0045596 negative regulation of cell differentiation 0.0290335719992359 697 8 3 0.375 0.00430416068866571
GO:BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 0.0297864522593106 133 80 4 0.05 0.0300751879699248
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.0305193012225875 141 37 3 0.0810810810810811 0.0212765957446809
GO:BP GO:0021954 central nervous system neuron development 0.0305193012225875 84 62 3 0.0483870967741935 0.0357142857142857
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.030692320396174 142 37 3 0.0810810810810811 0.0211267605633803
GO:BP GO:0045619 regulation of lymphocyte differentiation 0.0316511066907561 180 61 4 0.0655737704918033 0.0222222222222222
GO:BP GO:0048592 eye morphogenesis 0.0319118613436382 155 71 4 0.0563380281690141 0.0258064516129032
GO:BP GO:0033674 positive regulation of kinase activity 0.0319661331778268 608 125 11 0.088 0.0180921052631579
GO:BP GO:0010647 positive regulation of cell communication 0.0319661331778268 1777 71 15 0.211267605633803 0.0084411930219471
GO:BP GO:0009967 positive regulation of signal transduction 0.0319661331778268 1598 71 14 0.197183098591549 0.00876095118898623
GO:BP GO:0023056 positive regulation of signaling 0.0320991532092042 1782 71 15 0.211267605633803 0.00841750841750842
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0323747911303794 1564 129 21 0.162790697674419 0.0134271099744246
GO:BP GO:0044281 small molecule metabolic process 0.0330788441824138 1921 113 22 0.194690265486726 0.0114523685580427
GO:BP GO:0090596 sensory organ morphogenesis 0.0340001526612932 262 71 5 0.0704225352112676 0.0190839694656489
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 0.0340001526612932 148 38 3 0.0789473684210526 0.0202702702702703
GO:BP GO:0002312 B cell activation involved in immune response 0.0341889679618299 79 71 3 0.0422535211267606 0.0379746835443038
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.0343103162775292 155 37 3 0.0810810810810811 0.0193548387096774
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 0.0343103162775292 177 65 4 0.0615384615384615 0.0225988700564972
GO:BP GO:0006629 lipid metabolic process 0.0344568028423641 1457 113 18 0.15929203539823 0.0123541523678792
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.0344676477357866 1477 129 20 0.155038759689922 0.01354096140826
GO:BP GO:0010631 epithelial cell migration 0.0346104585148726 370 98 7 0.0714285714285714 0.0189189189189189
GO:BP GO:0051254 positive regulation of RNA metabolic process 0.0353756473506741 1714 8 4 0.5 0.00233372228704784
GO:BP GO:0090132 epithelium migration 0.0355133771288915 373 98 7 0.0714285714285714 0.0187667560321716
GO:BP GO:0006665 sphingolipid metabolic process 0.0356417019549405 169 70 4 0.0571428571428571 0.0236686390532544
GO:BP GO:0002274 myeloid leukocyte activation 0.0358513159532707 667 118 11 0.0932203389830508 0.0164917541229385
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0361446779281811 1227 114 16 0.140350877192982 0.013039934800326
GO:BP GO:1901136 carbohydrate derivative catabolic process 0.0361942446764838 196 61 4 0.0655737704918033 0.0204081632653061
GO:BP GO:0048871 multicellular organismal homeostasis 0.0365010827482712 530 53 6 0.113207547169811 0.0113207547169811
GO:BP GO:0032147 activation of protein kinase activity 0.0368196189050553 331 37 4 0.108108108108108 0.0120845921450151
GO:BP GO:0090130 tissue migration 0.0368196189050553 379 98 7 0.0714285714285714 0.0184696569920844
GO:BP GO:0065008 regulation of biological quality 0.0368196189050553 4131 53 21 0.39622641509434 0.00508351488743646
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.0368196189050553 1037 37 7 0.189189189189189 0.00675024108003857
GO:BP GO:1901890 positive regulation of cell junction assembly 0.0368196189050553 97 62 3 0.0483870967741935 0.0309278350515464
GO:BP GO:0001676 long-chain fatty acid metabolic process 0.0368823479554023 112 108 4 0.037037037037037 0.0357142857142857
GO:BP GO:0000187 activation of MAPK activity 0.0369356089899893 156 125 5 0.04 0.032051282051282
GO:BP GO:0061458 reproductive system development 0.0369703649034029 432 109 8 0.073394495412844 0.0185185185185185
GO:BP GO:0007399 nervous system development 0.0369703649034029 2449 114 26 0.228070175438596 0.0106165781951817
GO:BP GO:0045599 negative regulation of fat cell differentiation 0.0379661799656977 55 112 3 0.0267857142857143 0.0545454545454545
GO:BP GO:0050830 defense response to Gram-positive bacterium 0.0379675292631304 101 61 3 0.0491803278688525 0.0297029702970297
GO:BP GO:0048608 reproductive structure development 0.0382028788783422 429 88 7 0.0795454545454545 0.0163170163170163
GO:BP GO:0009743 response to carbohydrate 0.0384708695802864 243 26 3 0.115384615384615 0.0123456790123457
GO:BP GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 0.0385392708486061 71 88 3 0.0340909090909091 0.0422535211267606
GO:BP GO:1901888 regulation of cell junction assembly 0.0388924076941692 202 62 4 0.0645161290322581 0.0198019801980198
GO:BP GO:0060429 epithelium development 0.0388947124329824 1325 71 12 0.169014084507042 0.00905660377358491
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0393675088498493 1202 98 14 0.142857142857143 0.0116472545757072
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.0395649023869357 309 21 3 0.142857142857143 0.00970873786407767
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.0396984713924423 284 45 4 0.0888888888888889 0.0140845070422535
GO:BP GO:0042129 regulation of T cell proliferation 0.0403048836130396 176 37 3 0.0810810810810811 0.0170454545454545
GO:BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 0.0406568574981955 93 70 3 0.0428571428571429 0.032258064516129
GO:BP GO:0008202 steroid metabolic process 0.0408422567790129 342 113 7 0.0619469026548673 0.0204678362573099
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.0416532566352322 1887 8 4 0.5 0.00211976682564918
GO:BP GO:0060284 regulation of cell development 0.0418686505954885 502 98 8 0.0816326530612245 0.0159362549800797
GO:BP GO:0009725 response to hormone 0.0430925013330978 921 116 13 0.112068965517241 0.0141150922909881
GO:BP GO:0032649 regulation of interferon-gamma production 0.0431938391628796 110 61 3 0.0491803278688525 0.0272727272727273
GO:BP GO:0040011 locomotion 0.0438189570373679 2028 126 24 0.19047619047619 0.0118343195266272
GO:BP GO:0012501 programmed cell death 0.0443072736182268 2143 88 19 0.215909090909091 0.00886607559496034
GO:BP GO:0010906 regulation of glucose metabolic process 0.0443072736182268 120 112 4 0.0357142857142857 0.0333333333333333
GO:BP GO:0045862 positive regulation of proteolysis 0.0443072736182268 378 36 4 0.111111111111111 0.0105820105820106
GO:BP GO:0043085 positive regulation of catalytic activity 0.04513126052784 1418 37 8 0.216216216216216 0.00564174894217207
GO:BP GO:0032609 interferon-gamma production 0.04513126052784 115 61 3 0.0491803278688525 0.0260869565217391
GO:BP GO:0051093 negative regulation of developmental process 0.0459648751138702 977 8 3 0.375 0.00307062436028659
GO:BP GO:1901564 organonitrogen compound metabolic process 0.0462563797302723 6792 121 59 0.487603305785124 0.0086866902237927
GO:BP GO:1905953 negative regulation of lipid localization 0.0463948132577735 74 97 3 0.0309278350515464 0.0405405405405405
GO:BP GO:0043408 regulation of MAPK cascade 0.047234182013416 730 71 8 0.112676056338028 0.010958904109589
GO:BP GO:0001892 embryonic placenta development 0.0472493005821629 83 88 3 0.0340909090909091 0.036144578313253
GO:BP GO:0010952 positive regulation of peptidase activity 0.0473254273372364 205 36 3 0.0833333333333333 0.0146341463414634
GO:BP GO:0051246 regulation of protein metabolic process 0.0474704146964806 2704 113 27 0.238938053097345 0.00998520710059172
GO:BP GO:0043588 skin development 0.0475737533973131 424 53 5 0.0943396226415094 0.0117924528301887
GO:BP GO:0043067 regulation of programmed cell death 0.0478861010838681 1582 71 13 0.183098591549296 0.00821744627054362
GO:BP GO:0045087 innate immune response 0.0488360855985841 998 64 9 0.140625 0.00901803607214429
GO:BP GO:0051347 positive regulation of transferase activity 0.0489710649101807 689 125 11 0.088 0.0159651669085631
GO:BP GO:0034655 nucleobase-containing compound catabolic process 0.0490774753492178 567 26 4 0.153846153846154 0.00705467372134039
GO:BP GO:0042098 T cell proliferation 0.0497099302158041 205 37 3 0.0810810810810811 0.0146341463414634
GO:CC GO:0000139 Golgi membrane 0.0388206038243778 771 71 10 0.140845070422535 0.012970168612192
GO:CC GO:0005576 extracellular region 0.0388206038243778 4567 72 29 0.402777777777778 0.0063499014670462
GO:CC GO:0005615 extracellular space 0.0388206038243778 3594 61 22 0.360655737704918 0.00612131329994435
GO:CC GO:0005881 cytoplasmic microtubule 0.0388206038243778 76 51 3 0.0588235294117647 0.0394736842105263
GO:CC GO:0043235 receptor complex 0.0388206038243778 522 114 10 0.087719298245614 0.0191570881226054
GO:CC GO:0009897 external side of plasma membrane 0.0388206038243778 408 73 7 0.0958904109589041 0.017156862745098
GO:CC GO:0016021 integral component of membrane 0.0388206038243778 5711 75 36 0.48 0.00630362458413588
GO:CC GO:0031224 intrinsic component of membrane 0.0388206038243778 5868 75 36 0.48 0.00613496932515337
GO:CC GO:0035770 ribonucleoprotein granule 0.0388206038243778 248 18 3 0.166666666666667 0.0120967741935484
GO:CC GO:0036464 cytoplasmic ribonucleoprotein granule 0.0388206038243778 237 18 3 0.166666666666667 0.0126582278481013
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0388206038243778 885 71 10 0.140845070422535 0.0112994350282486
GO:CC GO:0098552 side of membrane 0.0442640456321085 619 73 8 0.10958904109589 0.012924071082391
GO:CC GO:0009986 cell surface 0.0442640456321085 899 73 10 0.136986301369863 0.0111234705228031
GO:CC GO:0031984 organelle subcompartment 0.0462266032118714 1773 103 19 0.184466019417476 0.0107163000564016
GO:CC GO:0012505 endomembrane system 0.0478122891615922 4640 123 44 0.357723577235772 0.00948275862068966
GO:MF GO:0005125 cytokine activity 0.000230571932265562 235 55 8 0.145454545454545 0.0340425531914894
GO:MF GO:0070888 E-box binding 0.00087418983891074 47 92 5 0.0543478260869565 0.106382978723404
GO:MF GO:0098531 ligand-activated transcription factor activity 0.00087418983891074 54 92 5 0.0543478260869565 0.0925925925925926
GO:MF GO:0004879 nuclear receptor activity 0.00087418983891074 54 92 5 0.0543478260869565 0.0925925925925926
GO:MF GO:0038024 cargo receptor activity 0.00087418983891074 78 113 6 0.0530973451327434 0.0769230769230769
GO:MF GO:0005126 cytokine receptor binding 0.00145259564202692 275 55 7 0.127272727272727 0.0254545454545455
GO:MF GO:0030546 signaling receptor activator activity 0.00332251969219612 501 38 7 0.184210526315789 0.0139720558882236
GO:MF GO:0048018 receptor ligand activity 0.00332251969219612 494 38 7 0.184210526315789 0.01417004048583
GO:MF GO:0030545 receptor regulator activity 0.00471465431724796 545 38 7 0.184210526315789 0.0128440366972477
GO:MF GO:0008134 transcription factor binding 0.0047494139998254 676 92 12 0.130434782608696 0.0177514792899408
GO:MF GO:0005164 tumor necrosis factor receptor binding 0.0047494139998254 32 55 3 0.0545454545454545 0.09375
GO:MF GO:0005102 signaling receptor binding 0.0133666002609244 1672 44 12 0.272727272727273 0.00717703349282297
GO:MF GO:0032813 tumor necrosis factor receptor superfamily binding 0.0133666002609244 49 55 3 0.0545454545454545 0.0612244897959184
GO:MF GO:0070491 repressing transcription factor binding 0.0133666002609244 73 90 4 0.0444444444444444 0.0547945205479452
GO:MF GO:0140297 DNA-binding transcription factor binding 0.0177512877437058 391 90 8 0.0888888888888889 0.020460358056266
GO:MF GO:0140375 immune receptor activity 0.0183756240731719 133 56 4 0.0714285714285714 0.0300751879699248
GO:MF GO:0051879 Hsp90 protein binding 0.0183756240731719 42 78 3 0.0384615384615385 0.0714285714285714
GO:MF GO:0008375 acetylglucosaminyltransferase activity 0.0347194721112427 51 85 3 0.0352941176470588 0.0588235294117647
GO:MF GO:0043394 proteoglycan binding 0.0347194721112427 36 122 3 0.0245901639344262 0.0833333333333333
GO:MF GO:0019955 cytokine binding 0.0356180075321883 138 70 4 0.0571428571428571 0.0289855072463768
GO:MF GO:0017124 SH3 domain binding 0.0356180075321883 129 128 5 0.0390625 0.0387596899224806
GO:MF GO:0005044 scavenger receptor activity 0.0357168518437305 48 112 3 0.0267857142857143 0.0625
GO:MF GO:0060089 molecular transducer activity 0.0357168518437305 1458 114 18 0.157894736842105 0.0123456790123457
GO:MF GO:0008081 phosphoric diester hydrolase activity 0.0357168518437305 92 112 4 0.0357142857142857 0.0434782608695652
GO:MF GO:0016836 hydro-lyase activity 0.0357168518437305 65 76 3 0.0394736842105263 0.0461538461538462
GO:MF GO:0001221 transcription coregulator binding 0.0357168518437305 63 92 3 0.0326086956521739 0.0476190476190476
GO:MF GO:0016829 lyase activity 0.0357168518437305 203 94 5 0.0531914893617021 0.0246305418719212
GO:MF GO:0046872 metal ion binding 0.0357168518437305 4260 96 34 0.354166666666667 0.007981220657277
GO:MF GO:0038023 signaling receptor activity 0.0357168518437305 1458 114 18 0.157894736842105 0.0123456790123457
GO:MF GO:0043169 cation binding 0.0357168518437305 4351 97 35 0.360824742268041 0.0080441277867157
GO:MF GO:0003824 catalytic activity 0.0357168518437305 5896 121 53 0.43801652892562 0.00898914518317503
GO:MF GO:0004896 cytokine receptor activity 0.0357168518437305 99 56 3 0.0535714285714286 0.0303030303030303
GO:MF GO:0016835 carbon-oxygen lyase activity 0.0368294113812646 81 76 3 0.0394736842105263 0.037037037037037
GO:MF GO:0016787 hydrolase activity 0.0417640186449056 2615 112 26 0.232142857142857 0.00994263862332696
GO:MF GO:0098772 molecular function regulator 0.0423538230884561 2363 38 11 0.289473684210526 0.00465509944985188
GO:MF GO:0004252 serine-type endopeptidase activity 0.0443990559462158 171 42 3 0.0714285714285714 0.0175438596491228
GO:MF GO:0016788 hydrolase activity, acting on ester bonds 0.0443990559462158 773 112 11 0.0982142857142857 0.0142302716688228
GO:MF GO:0004714 transmembrane receptor protein tyrosine kinase activity 0.0443990559462158 63 114 3 0.0263157894736842 0.0476190476190476
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.0499711548122193 281 116 6 0.0517241379310345 0.0213523131672598
GO:MF GO:0042578 phosphoric ester hydrolase activity 0.0499711548122193 383 112 7 0.0625 0.0182767624020888
KEGG KEGG:05321 Inflammatory bowel disease 6.27358842026605e-05 62 38 6 0.157894736842105 0.0967741935483871
KEGG KEGG:04060 Cytokine-cytokine receptor interaction 0.000267700780457759 293 65 12 0.184615384615385 0.0409556313993174
KEGG KEGG:04659 Th17 cell differentiation 0.000446622489626311 104 38 6 0.157894736842105 0.0576923076923077
KEGG KEGG:04710 Circadian rhythm 0.000985081082016024 31 92 5 0.0543478260869565 0.161290322580645
KEGG KEGG:05323 Rheumatoid arthritis 0.00475699527886341 88 10 3 0.3 0.0340909090909091
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.00119041372395222 446 38 10 0.263157894736842 0.0224215246636771
REAC REAC:R-HSA-168256 Immune System 0.00212399150861858 2139 38 20 0.526315789473684 0.00935016362786349
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.003534382534975 842 38 12 0.315789473684211 0.0142517814726841
REAC REAC:R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.00474648115752475 110 38 5 0.131578947368421 0.0454545454545455
REAC REAC:R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway 0.00632429707208124 16 55 3 0.0545454545454545 0.1875
REAC REAC:R-HSA-447115 Interleukin-12 family signaling 0.0162413943128918 55 23 3 0.130434782608696 0.0545454545454545
REAC REAC:R-HSA-383280 Nuclear Receptor transcription pathway 0.0236801795328677 41 92 4 0.0434782608695652 0.0975609756097561
REAC REAC:R-HSA-400206 Regulation of lipid metabolism by PPARalpha 0.0300910986696359 116 97 6 0.0618556701030928 0.0517241379310345
REAC REAC:R-HSA-1989781 PPARA activates gene expression 0.0300910986696359 115 97 6 0.0618556701030928 0.0521739130434783
WP WP:WP3893 Development and heterogeneity of the ILC family 0.000484679600386483 32 7 3 0.428571428571429 0.09375
WP WP:WP3892 Development of pulmonary dendritic cells and macrophage subsets 0.0407352107397879 13 88 3 0.0340909090909091 0.230769230769231

pTNI21 transcription factor target enrichment of top program genes

TF enrichment of pTNI21
TFs corrosponding to activation of pTNI21. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.