pTNI16 program activity among T/NK/ILC cells

Activation of pTNI16
pTNI16 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI16 by different cell subtypes
pTNI16 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI16 top program genes

Top genes of pTNI16 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI16 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI16
pTNI16 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0001906 cell killing 1.25962556533735e-06 175 6 5 0.833333333333333 0.0285714285714286
GO:BP GO:0051707 response to other organism 7.64794703560039e-06 1592 11 9 0.818181818181818 0.00565326633165829
GO:BP GO:0001909 leukocyte mediated cytotoxicity 7.64794703560039e-06 107 6 4 0.666666666666667 0.0373831775700935
GO:BP GO:0009607 response to biotic stimulus 7.64794703560039e-06 1626 11 9 0.818181818181818 0.00553505535055351
GO:BP GO:0043207 response to external biotic stimulus 7.64794703560039e-06 1594 11 9 0.818181818181818 0.00564617314930991
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 7.64794703560039e-06 2255 11 10 0.909090909090909 0.00443458980044346
GO:BP GO:0098542 defense response to other organism 3.47380385469399e-05 1218 6 6 1 0.00492610837438424
GO:BP GO:0019835 cytolysis 9.27832380429898e-05 32 8 3 0.375 0.09375
GO:BP GO:0006955 immune response 0.00010137754372351 2311 11 9 0.818181818181818 0.00389441800086543
GO:BP GO:0006968 cellular defense response 0.00010137754372351 53 21 4 0.19047619047619 0.0754716981132075
GO:BP GO:0042267 natural killer cell mediated cytotoxicity 0.000183514799359184 62 6 3 0.5 0.0483870967741935
GO:BP GO:0002228 natural killer cell mediated immunity 0.000194214406921191 65 6 3 0.5 0.0461538461538462
GO:BP GO:0006952 defense response 0.000207686917242135 1818 6 6 1 0.0033003300330033
GO:BP GO:0002376 immune system process 0.000268940722906108 3278 14 11 0.785714285714286 0.00335570469798658
GO:BP GO:0002443 leukocyte mediated immunity 0.000268940722906108 877 6 5 0.833333333333333 0.00570125427594071
GO:BP GO:0002449 lymphocyte mediated immunity 0.000347059662088142 354 6 4 0.666666666666667 0.0112994350282486
GO:BP GO:0031341 regulation of cell killing 0.000383313232993859 93 6 3 0.5 0.032258064516129
GO:BP GO:0009605 response to external stimulus 0.000440069974175244 2944 11 9 0.818181818181818 0.0030570652173913
GO:BP GO:0048583 regulation of response to stimulus 0.0010395894922308 4278 44 24 0.545454545454545 0.00561009817671809
GO:BP GO:0002252 immune effector process 0.00108801755397852 1309 6 5 0.833333333333333 0.00381970970206264
GO:BP GO:1905521 regulation of macrophage migration 0.00108801755397852 42 19 3 0.157894736842105 0.0714285714285714
GO:BP GO:0009617 response to bacterium 0.0011162353046417 743 9 5 0.555555555555556 0.00672947510094213
GO:BP GO:0045321 leukocyte activation 0.00174301889111011 1332 14 7 0.5 0.00525525525525526
GO:BP GO:1905517 macrophage migration 0.00174301889111011 56 19 3 0.157894736842105 0.0535714285714286
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.00174301889111011 1037 17 7 0.411764705882353 0.00675024108003857
GO:BP GO:0008347 glial cell migration 0.00174301889111011 56 19 3 0.157894736842105 0.0535714285714286
GO:BP GO:0009967 positive regulation of signal transduction 0.00265047829556973 1598 17 8 0.470588235294118 0.00500625782227785
GO:BP GO:0001775 cell activation 0.00317646636148517 1495 14 7 0.5 0.00468227424749164
GO:BP GO:0023056 positive regulation of signaling 0.00421037195904484 1782 35 12 0.342857142857143 0.00673400673400673
GO:BP GO:0006954 inflammatory response 0.00421037195904484 794 18 6 0.333333333333333 0.00755667506297229
GO:BP GO:0009988 cell-cell recognition 0.00421037195904484 82 19 3 0.157894736842105 0.0365853658536585
GO:BP GO:0010647 positive regulation of cell communication 0.00421037195904484 1777 35 12 0.342857142857143 0.00675295441755768
GO:BP GO:0071222 cellular response to lipopolysaccharide 0.00513449442810239 200 9 3 0.333333333333333 0.015
GO:BP GO:0032101 regulation of response to external stimulus 0.00539295200018083 1051 35 9 0.257142857142857 0.00856327307326356
GO:BP GO:0045087 innate immune response 0.00539295200018083 998 6 4 0.666666666666667 0.00400801603206413
GO:BP GO:0071219 cellular response to molecule of bacterial origin 0.00539295200018083 214 9 3 0.333333333333333 0.014018691588785
GO:BP GO:0006950 response to stress 0.00607737732737332 4170 6 6 1 0.00143884892086331
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00615755557579529 363 6 3 0.5 0.00826446280991736
GO:BP GO:0071216 cellular response to biotic stimulus 0.00694889628508731 238 9 3 0.333333333333333 0.0126050420168067
GO:BP GO:1902531 regulation of intracellular signal transduction 0.00719786210498149 1842 27 10 0.37037037037037 0.00542888165038002
GO:BP GO:0090280 positive regulation of calcium ion import 0.00719786210498149 21 98 3 0.0306122448979592 0.142857142857143
GO:BP GO:0002520 immune system development 0.00719786210498149 1020 11 5 0.454545454545455 0.00490196078431373
GO:BP GO:0002682 regulation of immune system process 0.00783367339478375 1617 42 12 0.285714285714286 0.00742115027829314
GO:BP GO:0050896 response to stimulus 0.00800570790711762 9407 40 32 0.8 0.00340172212182417
GO:BP GO:0065009 regulation of molecular function 0.00800570790711762 3221 47 19 0.404255319148936 0.00589878919590189
GO:BP GO:0043085 positive regulation of catalytic activity 0.00801283107382198 1418 35 10 0.285714285714286 0.00705218617771509
GO:BP GO:0043068 positive regulation of programmed cell death 0.00801283107382198 621 10 4 0.4 0.00644122383252818
GO:BP GO:0002521 leukocyte differentiation 0.00801283107382198 550 11 4 0.363636363636364 0.00727272727272727
GO:BP GO:0002683 negative regulation of immune system process 0.00801283107382198 420 6 3 0.5 0.00714285714285714
GO:BP GO:0010942 positive regulation of cell death 0.0102085953486526 684 10 4 0.4 0.00584795321637427
GO:BP GO:0002685 regulation of leukocyte migration 0.0109518137962341 211 30 4 0.133333333333333 0.018957345971564
GO:BP GO:0051897 positive regulation of protein kinase B signaling 0.0117199045436973 184 35 4 0.114285714285714 0.0217391304347826
GO:BP GO:0007165 signal transduction 0.0117629966861492 6309 69 38 0.550724637681159 0.00602314154382628
GO:BP GO:0097529 myeloid leukocyte migration 0.0120235308614133 221 30 4 0.133333333333333 0.0180995475113122
GO:BP GO:0001570 vasculogenesis 0.0121248614781988 84 78 4 0.0512820512820513 0.0476190476190476
GO:BP GO:0046649 lymphocyte activation 0.0123517062274221 771 10 4 0.4 0.00518806744487678
GO:BP GO:0032102 negative regulation of response to external stimulus 0.0123517062274221 406 30 5 0.166666666666667 0.0123152709359606
GO:BP GO:0032496 response to lipopolysaccharide 0.0123517062274221 338 9 3 0.333333333333333 0.00887573964497041
GO:BP GO:0044092 negative regulation of molecular function 0.0123517062274221 1219 68 13 0.191176470588235 0.0106644790812141
GO:BP GO:0048522 positive regulation of cellular process 0.0123517062274221 5757 18 13 0.722222222222222 0.00225812054889699
GO:BP GO:0002237 response to molecule of bacterial origin 0.0128408649847652 361 9 3 0.333333333333333 0.00831024930747922
GO:BP GO:0048584 positive regulation of response to stimulus 0.0133437370452687 2344 17 8 0.470588235294118 0.00341296928327645
GO:BP GO:0048519 negative regulation of biological process 0.0137530631800784 5757 31 19 0.612903225806452 0.0033003300330033
GO:BP GO:0023052 signaling 0.0137530631800784 6810 35 23 0.657142857142857 0.00337738619676946
GO:BP GO:0007154 cell communication 0.0140762348920886 6829 35 23 0.657142857142857 0.00336798945672866
GO:BP GO:0050790 regulation of catalytic activity 0.0155523684328258 2545 45 15 0.333333333333333 0.00589390962671906
GO:BP GO:0048589 developmental growth 0.0159392107604044 649 44 7 0.159090909090909 0.0107858243451464
GO:BP GO:0031623 receptor internalization 0.0162572495369899 116 30 3 0.1 0.0258620689655172
GO:BP GO:0050920 regulation of chemotaxis 0.0162572495369899 226 35 4 0.114285714285714 0.0176991150442478
GO:BP GO:1905477 positive regulation of protein localization to membrane 0.01679247969148 131 27 3 0.111111111111111 0.0229007633587786
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0172575589177691 810 11 4 0.363636363636364 0.00493827160493827
GO:BP GO:0002250 adaptive immune response 0.0172575589177691 689 6 3 0.5 0.00435413642960813
GO:BP GO:0002688 regulation of leukocyte chemotaxis 0.0172575589177691 120 30 3 0.1 0.025
GO:BP GO:0008219 cell death 0.017816536202304 2292 11 6 0.545454545454545 0.00261780104712042
GO:BP GO:0031347 regulation of defense response 0.017816536202304 704 6 3 0.5 0.00426136363636364
GO:BP GO:0010941 regulation of cell death 0.0187947781405827 1720 35 10 0.285714285714286 0.00581395348837209
GO:BP GO:0032835 glomerulus development 0.0200389828443182 62 64 3 0.046875 0.0483870967741935
GO:BP GO:0050900 leukocyte migration 0.0200389828443182 511 30 5 0.166666666666667 0.00978473581213307
GO:BP GO:0002274 myeloid leukocyte activation 0.0200389828443182 667 14 4 0.285714285714286 0.00599700149925037
GO:BP GO:0010646 regulation of cell communication 0.0200389828443182 3543 35 15 0.428571428571429 0.00423370025402202
GO:BP GO:0044093 positive regulation of molecular function 0.0207428290827865 1771 35 10 0.285714285714286 0.00564652738565782
GO:BP GO:0030516 regulation of axon extension 0.0209141850946475 97 42 3 0.0714285714285714 0.0309278350515464
GO:BP GO:0048518 positive regulation of biological process 0.0210341606236261 6363 18 13 0.722222222222222 0.00204306144900204
GO:BP GO:0080134 regulation of response to stress 0.0210864956364997 1443 29 8 0.275862068965517 0.00554400554400554
GO:BP GO:0051896 regulation of protein kinase B signaling 0.0211444093222413 259 35 4 0.114285714285714 0.0154440154440154
GO:BP GO:0023051 regulation of signaling 0.0211640555184002 3578 35 15 0.428571428571429 0.00419228619340414
GO:BP GO:0090279 regulation of calcium ion import 0.0217306718154699 43 98 3 0.0306122448979592 0.0697674418604651
GO:BP GO:0030097 hemopoiesis 0.022060171140753 928 11 4 0.363636363636364 0.00431034482758621
GO:BP GO:0048523 negative regulation of cellular process 0.0223669958119958 5139 31 17 0.548387096774194 0.0033080365829928
GO:BP GO:0031348 negative regulation of defense response 0.0223669958119958 246 18 3 0.166666666666667 0.0121951219512195
GO:BP GO:0050776 regulation of immune response 0.0230824735576567 996 42 8 0.19047619047619 0.00803212851405622
GO:BP GO:0048585 negative regulation of response to stimulus 0.0237202248537195 1733 31 9 0.290322580645161 0.0051933064050779
GO:BP GO:0043270 positive regulation of ion transport 0.0237202248537195 694 35 6 0.171428571428571 0.00864553314121038
GO:BP GO:0051716 cellular response to stimulus 0.0237202248537195 7781 35 24 0.685714285714286 0.00308443644775736
GO:BP GO:1903131 mononuclear cell differentiation 0.0237202248537195 430 11 3 0.272727272727273 0.00697674418604651
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.0237345308629893 966 11 4 0.363636363636364 0.0041407867494824
GO:BP GO:0060560 developmental growth involved in morphogenesis 0.025243641651153 236 42 4 0.0952380952380952 0.0169491525423729
GO:BP GO:0061387 regulation of extent of cell growth 0.025243641651153 110 42 3 0.0714285714285714 0.0272727272727273
GO:BP GO:0043491 protein kinase B signaling 0.025243641651153 286 35 4 0.114285714285714 0.013986013986014
GO:BP GO:1901214 regulation of neuron death 0.025243641651153 323 31 4 0.129032258064516 0.0123839009287926
GO:BP GO:0071396 cellular response to lipid 0.0266410142307342 578 9 3 0.333333333333333 0.00519031141868512
GO:BP GO:0006915 apoptotic process 0.0274345611735302 1990 10 5 0.5 0.00251256281407035
GO:BP GO:0050921 positive regulation of chemotaxis 0.0275437647851581 141 35 3 0.0857142857142857 0.0212765957446809
GO:BP GO:0010712 regulation of collagen metabolic process 0.0277550759242622 52 95 3 0.0315789473684211 0.0576923076923077
GO:BP GO:0048675 axon extension 0.0295039558089425 122 42 3 0.0714285714285714 0.0245901639344262
GO:BP GO:0060326 cell chemotaxis 0.0299244549839962 310 35 4 0.114285714285714 0.0129032258064516
GO:BP GO:0043112 receptor metabolic process 0.0300508669396765 174 30 3 0.1 0.0172413793103448
GO:BP GO:0071310 cellular response to organic substance 0.0302433634447277 2776 11 6 0.545454545454545 0.00216138328530259
GO:BP GO:0032103 positive regulation of response to external stimulus 0.0312743288030783 513 11 3 0.272727272727273 0.00584795321637427
GO:BP GO:1905475 regulation of protein localization to membrane 0.0317901222737035 201 27 3 0.111111111111111 0.0149253731343284
GO:BP GO:0070997 neuron death 0.0319026774207451 365 31 4 0.129032258064516 0.010958904109589
GO:BP GO:0072006 nephron development 0.0319026774207451 142 78 4 0.0512820512820513 0.028169014084507
GO:BP GO:1903034 regulation of response to wounding 0.0321931740661446 169 66 4 0.0606060606060606 0.0236686390532544
GO:BP GO:0012501 programmed cell death 0.0331780674451895 2143 10 5 0.5 0.00233317778814746
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0333773663377831 1132 11 4 0.363636363636364 0.00353356890459364
GO:BP GO:0051345 positive regulation of hydrolase activity 0.033515259167862 783 35 6 0.171428571428571 0.00766283524904215
GO:BP GO:0001817 regulation of cytokine production 0.0335965498733891 806 15 4 0.266666666666667 0.00496277915632754
GO:BP GO:0043065 positive regulation of apoptotic process 0.0343455211095526 604 10 3 0.3 0.00496688741721854
GO:BP GO:0009966 regulation of signal transduction 0.0349294166024825 3165 27 11 0.407407407407407 0.00347551342812006
GO:BP GO:0042063 gliogenesis 0.0350776975794317 308 19 3 0.157894736842105 0.00974025974025974
GO:BP GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 0.0361881112969327 61 95 3 0.0315789473684211 0.0491803278688525
GO:BP GO:0030335 positive regulation of cell migration 0.0363476054512456 567 11 3 0.272727272727273 0.00529100529100529
GO:BP GO:0048871 multicellular organismal homeostasis 0.0363476054512456 530 23 4 0.173913043478261 0.00754716981132075
GO:BP GO:0035556 intracellular signal transduction 0.0364109478863576 2772 35 12 0.342857142857143 0.00432900432900433
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.0364109478863576 251 24 3 0.125 0.0119521912350598
GO:BP GO:0001816 cytokine production 0.0364109478863576 844 15 4 0.266666666666667 0.004739336492891
GO:BP GO:0007266 Rho protein signal transduction 0.0367801948501607 136 44 3 0.0681818181818182 0.0220588235294118
GO:BP GO:0043086 negative regulation of catalytic activity 0.0367801948501607 851 68 9 0.132352941176471 0.0105757931844888
GO:BP GO:0048167 regulation of synaptic plasticity 0.0378213107780144 185 33 3 0.0909090909090909 0.0162162162162162
GO:BP GO:0001894 tissue homeostasis 0.0378213107780144 270 23 3 0.130434782608696 0.0111111111111111
GO:BP GO:0034097 response to cytokine 0.0378213107780144 1226 11 4 0.363636363636364 0.0032626427406199
GO:BP GO:2000147 positive regulation of cell motility 0.0378213107780144 591 11 3 0.272727272727273 0.0050761421319797
GO:BP GO:0010629 negative regulation of gene expression 0.0378213107780144 1460 5 3 0.6 0.00205479452054795
GO:BP GO:0051272 positive regulation of cellular component movement 0.038904338653072 604 11 3 0.272727272727273 0.00496688741721854
GO:BP GO:0032880 regulation of protein localization 0.038904338653072 922 32 6 0.1875 0.00650759219088937
GO:BP GO:0040017 positive regulation of locomotion 0.0390816803865932 606 11 3 0.272727272727273 0.00495049504950495
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0390816803865932 1455 15 5 0.333333333333333 0.00343642611683849
GO:BP GO:0030163 protein catabolic process 0.0408193192379602 974 14 4 0.285714285714286 0.00410677618069815
GO:BP GO:0001819 positive regulation of cytokine production 0.0412050344723671 452 15 3 0.2 0.00663716814159292
GO:BP GO:0032879 regulation of localization 0.0412050344723671 2872 35 12 0.342857142857143 0.00417827298050139
GO:BP GO:0035773 insulin secretion involved in cellular response to glucose stimulus 0.0412050344723671 69 95 3 0.0315789473684211 0.0434782608695652
GO:BP GO:1901215 negative regulation of neuron death 0.0412050344723671 213 31 3 0.0967741935483871 0.0140845070422535
GO:BP GO:0050770 regulation of axonogenesis 0.0418773419137306 159 42 3 0.0714285714285714 0.0188679245283019
GO:BP GO:0030595 leukocyte chemotaxis 0.0427921071858658 227 30 3 0.1 0.013215859030837
GO:BP GO:0040007 growth 0.0437385898631925 967 99 12 0.121212121212121 0.0124095139607032
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.0439447260198882 291 24 3 0.125 0.0103092783505155
GO:BP GO:0043547 positive regulation of GTPase activity 0.0439447260198882 413 33 4 0.121212121212121 0.00968523002421308
GO:BP GO:1990138 neuron projection extension 0.046541418760383 170 42 3 0.0714285714285714 0.0176470588235294
GO:BP GO:0050804 modulation of chemical synaptic transmission 0.0471287315468077 430 33 4 0.121212121212121 0.00930232558139535
GO:BP GO:0099177 regulation of trans-synaptic signaling 0.0471915081897044 431 33 4 0.121212121212121 0.00928074245939675
GO:BP GO:0048638 regulation of developmental growth 0.0474323358932053 340 42 4 0.0952380952380952 0.0117647058823529
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0474323358932053 547 14 3 0.214285714285714 0.00548446069469835
GO:BP GO:0051050 positive regulation of transport 0.0477398789576262 923 35 6 0.171428571428571 0.00650054171180932
GO:BP GO:0006935 chemotaxis 0.0477538788543891 653 35 5 0.142857142857143 0.00765696784073507
GO:BP GO:0043067 regulation of programmed cell death 0.0477538788543891 1582 10 4 0.4 0.00252844500632111
GO:BP GO:0070887 cellular response to chemical stimulus 0.0482301678458912 3393 11 6 0.545454545454545 0.0017683465959328
GO:BP GO:0019222 regulation of metabolic process 0.0482301678458912 7148 15 11 0.733333333333333 0.00153889199776161
GO:BP GO:0042330 taxis 0.0482301678458912 656 35 5 0.142857142857143 0.00762195121951219
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0485216941389216 3483 17 8 0.470588235294118 0.00229687051392478
GO:BP GO:0010033 response to organic substance 0.0485216941389216 3412 11 6 0.545454545454545 0.00175849941383353
GO:BP GO:0008361 regulation of cell size 0.0485216941389216 182 42 3 0.0714285714285714 0.0164835164835165
GO:BP GO:0033993 response to lipid 0.0486393120300361 918 9 3 0.333333333333333 0.00326797385620915
GO:BP GO:0001822 kidney development 0.0486393120300361 293 78 5 0.0641025641025641 0.0170648464163823
GO:BP GO:0048639 positive regulation of developmental growth 0.0489378328181201 184 42 3 0.0714285714285714 0.016304347826087
GO:BP GO:0001558 regulation of cell growth 0.0489378328181201 426 99 7 0.0707070707070707 0.0164319248826291
GO:CC GO:0001772 immunological synapse 9.38717776530852e-05 43 8 3 0.375 0.0697674418604651
GO:CC GO:0097708 intracellular vesicle 0.020503691983121 2428 14 7 0.5 0.0028830313014827
GO:CC GO:0005768 endosome 0.020503691983121 987 13 5 0.384615384615385 0.00506585612968592
GO:CC GO:0000323 lytic vacuole 0.020503691983121 712 43 7 0.162790697674419 0.0098314606741573
GO:CC GO:0031410 cytoplasmic vesicle 0.020503691983121 2424 14 7 0.5 0.00288778877887789
GO:CC GO:0005764 lysosome 0.020503691983121 712 43 7 0.162790697674419 0.0098314606741573
GO:CC GO:0030139 endocytic vesicle 0.020503691983121 306 93 7 0.0752688172043011 0.0228758169934641
GO:CC GO:0005773 vacuole 0.0275610778347369 810 43 7 0.162790697674419 0.00864197530864197
GO:CC GO:0016020 membrane 0.0325589112475205 9838 37 28 0.756756756756757 0.00284610693230331
GO:CC GO:0005576 extracellular region 0.0373542314578648 4567 4 4 1 0.000875848478213269
GO:CC GO:0005886 plasma membrane 0.0439970565272566 5681 11 8 0.727272727272727 0.00140820278120049
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0474661711910891 735 29 5 0.172413793103448 0.00680272108843537
GO:MF GO:0017171 serine hydrolase activity 0.0259447111804306 193 14 3 0.214285714285714 0.0155440414507772
GO:MF GO:0008236 serine-type peptidase activity 0.0259447111804306 189 14 3 0.214285714285714 0.0158730158730159
GO:MF GO:0008047 enzyme activator activity 0.0259447111804306 540 33 6 0.181818181818182 0.0111111111111111
GO:MF GO:0005102 signaling receptor binding 0.0259447111804306 1672 64 15 0.234375 0.00897129186602871
GO:MF GO:0019904 protein domain specific binding 0.0287066072011303 710 40 7 0.175 0.00985915492957747
GO:MF GO:0017124 SH3 domain binding 0.0443517649357529 129 39 3 0.0769230769230769 0.0232558139534884
GO:MF GO:0030246 carbohydrate binding 0.0488247270512794 275 70 5 0.0714285714285714 0.0181818181818182
KEGG KEGG:05332 Graft-versus-host disease 3.34530943252846e-07 37 52 7 0.134615384615385 0.189189189189189
KEGG KEGG:04650 Natural killer cell mediated cytotoxicity 0.000111250249564198 123 56 8 0.142857142857143 0.0650406504065041
KEGG KEGG:04612 Antigen processing and presentation 0.000297517293473478 69 56 6 0.107142857142857 0.0869565217391304
KEGG KEGG:04142 Lysosome 0.00730669668762426 128 23 4 0.173913043478261 0.03125
KEGG KEGG:05323 Rheumatoid arthritis 0.0252450202435275 88 23 3 0.130434782608696 0.0340909090909091
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.0119367177569445 446 11 5 0.454545454545455 0.0112107623318386
REAC REAC:R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 0.030015582553214 181 52 6 0.115384615384615 0.0331491712707182
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.0396243140137486 842 11 5 0.454545454545455 0.00593824228028504
REAC REAC:R-HSA-168256 Immune System 0.0396243140137486 2139 17 10 0.588235294117647 0.00467508181393174
TF TF:M08938 Factor: C-JUN:FRA-1; motif: NNATGACTCATNN 0.0398311079282283 3714 13 9 0.692307692307692 0.0024232633279483
TF TF:M00517_1 Factor: AP-1; motif: NNNTGAGTCAKCN; match class: 1 0.0398311079282283 3227 13 9 0.692307692307692 0.00278896808180973
TF TF:M00199 Factor: AP-1; motif: NTGASTCAG 0.0398311079282283 4833 13 10 0.769230769230769 0.00206910821435961
TF TF:M12354_1 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN; match class: 1 0.0398311079282283 5624 70 35 0.5 0.00622332859174964
TF TF:M12354 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN 0.0398311079282283 10961 68 53 0.779411764705882 0.00483532524404708
TF TF:M00173 Factor: AP-1; motif: RSTGACTNANW 0.0398311079282283 2737 13 8 0.615384615384615 0.00292290829375228
TF TF:M06948 Factor: Sp2; motif: TGGGCGCGCCCA 0.0398311079282283 8864 49 36 0.73469387755102 0.00406137184115523
TF TF:M00005_1 Factor: AP-4; motif: WGARYCAGCTGYGGNCNK; match class: 1 0.0398311079282283 1039 19 7 0.368421052631579 0.00673724735322425
TF TF:M10068_1 Factor: Sox-3; motif: NCCTTTGTNYN; match class: 1 0.0398311079282283 78 51 4 0.0784313725490196 0.0512820512820513
TF TF:M11729 Factor: NF-1C; motif: NTTGGCNNNNTGCCARN 0.0398311079282283 1738 64 16 0.25 0.00920598388952819
TF TF:M00531 Factor: nerf; motif: YRNCAGGAAGYRGSTBDS 0.0398311079282283 7615 64 42 0.65625 0.00551543007222587
TF TF:M12183 Factor: KLF14; motif: NRCCACRCCCMCN 0.0398311079282283 6878 48 30 0.625 0.00436173306193661
TF TF:M07375 Factor: BCL-6; motif: TTCCTAGAAA 0.0398311079282283 556 37 7 0.189189189189189 0.012589928057554
TF TF:M09965 Factor: c-Jun; motif: NRTGAGTCAYN 0.0398311079282283 4492 13 10 0.769230769230769 0.00222617987533393
TF TF:M01196 Factor: CTF1; motif: TGGCASCNNGCCAA 0.0398311079282283 4864 64 31 0.484375 0.00637335526315789
TF TF:M00807 Factor: Egr; motif: GTGGGSGCRRS 0.0398311079282283 4343 82 34 0.414634146341463 0.00782868984572876
TF TF:M09938_1 Factor: GATA-3; motif: NNAGATAANAN; match class: 1 0.0398311079282283 374 41 6 0.146341463414634 0.0160427807486631
TF TF:M08933 Factor: JUND:C-FOS; motif: NNATGAGTCATNN 0.0398311079282283 4818 13 10 0.769230769230769 0.0020755500207555
TF TF:M09915_1 Factor: PEA3; motif: NNCAGGAARNN; match class: 1 0.0430595778428649 5690 62 32 0.516129032258065 0.00562390158172232
TF TF:M11265 Factor: c-Jun; motif: NATGACTCATN 0.047461863787514 4632 6 6 1 0.00129533678756477
TF TF:M11264 Factor: c-Jun; motif: NATGASTCATN 0.047461863787514 4600 6 6 1 0.00130434782608696
TF TF:M07102 Factor: c-Jun; motif: NNNNRRTGASTCAN 0.047461863787514 5099 13 10 0.769230769230769 0.00196116885663856
TF TF:M08929 Factor: JUND:FRA-1; motif: NRTGACTCAN 0.0486929575462487 1560 5 4 0.8 0.00256410256410256
WP WP:WP2328 Allograft Rejection 0.000229792766992789 88 3 3 1 0.0340909090909091

pTNI16 transcription factor target enrichment of top program genes

TF enrichment of pTNI16
TFs corrosponding to activation of pTNI16. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.