pEpi31 program activity among Epithelial cells

Activation of pEpi31
pEpi31 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi31 by different cell subtypes
pEpi31 gene program activation among cells of different subtypes (Epithelial cells).

pEpi31 top program genes

Top genes of pEpi31 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi31 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi31
pEpi31 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0006910 phagocytosis, recognition 1.17660461392929e-05 98 45 7 0.155555555555556 0.0714285714285714
GO:BP GO:0050900 leukocyte migration 2.31470371733227e-05 511 44 11 0.25 0.0215264187866928
GO:BP GO:0050853 B cell receptor signaling pathway 2.31470371733227e-05 135 45 7 0.155555555555556 0.0518518518518519
GO:BP GO:0099024 plasma membrane invagination 2.31470371733227e-05 136 45 7 0.155555555555556 0.0514705882352941
GO:BP GO:0006911 phagocytosis, engulfment 2.31470371733227e-05 127 45 7 0.155555555555556 0.0551181102362205
GO:BP GO:0010324 membrane invagination 2.45231730524658e-05 144 45 7 0.155555555555556 0.0486111111111111
GO:BP GO:0006958 complement activation, classical pathway 2.45231730524658e-05 142 45 7 0.155555555555556 0.0492957746478873
GO:BP GO:0050871 positive regulation of B cell activation 2.97378536480241e-05 151 45 7 0.155555555555556 0.0463576158940397
GO:BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 3.30507563431398e-05 156 45 7 0.155555555555556 0.0448717948717949
GO:BP GO:0042742 defense response to bacterium 4.38081115267335e-05 349 45 9 0.2 0.0257879656160458
GO:BP GO:0009617 response to bacterium 4.38081115267335e-05 743 45 12 0.266666666666667 0.0161507402422611
GO:BP GO:0050864 regulation of B cell activation 5.57338389888522e-05 194 60 8 0.133333333333333 0.0412371134020619
GO:BP GO:0006956 complement activation 6.07164886998405e-05 180 45 7 0.155555555555556 0.0388888888888889
GO:BP GO:0060267 positive regulation of respiratory burst 0.000193649658244016 9 42 3 0.0714285714285714 0.333333333333333
GO:BP GO:0019724 B cell mediated immunity 0.000214955047017929 226 45 7 0.155555555555556 0.0309734513274336
GO:BP GO:0045730 respiratory burst 0.000214955047017929 35 42 4 0.0952380952380952 0.114285714285714
GO:BP GO:0016064 immunoglobulin mediated immune response 0.000214955047017929 223 45 7 0.155555555555556 0.031390134529148
GO:BP GO:0008037 cell recognition 0.000263392093628004 235 45 7 0.155555555555556 0.0297872340425532
GO:BP GO:0001895 retina homeostasis 0.000397492381071891 79 7 3 0.428571428571429 0.0379746835443038
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.000397492381071891 365 45 8 0.177777777777778 0.0219178082191781
GO:BP GO:0065008 regulation of biological quality 0.000418834931706242 4131 86 39 0.453488372093023 0.00944081336238199
GO:BP GO:0006959 humoral immune response 0.000525744163915499 384 45 8 0.177777777777778 0.0208333333333333
GO:BP GO:0016192 vesicle-mediated transport 0.000652557576938946 2180 76 24 0.315789473684211 0.0110091743119266
GO:BP GO:0060263 regulation of respiratory burst 0.000744615584776504 16 42 3 0.0714285714285714 0.1875
GO:BP GO:0002696 positive regulation of leukocyte activation 0.000775607213524043 412 45 8 0.177777777777778 0.0194174757281553
GO:BP GO:0050867 positive regulation of cell activation 0.000919669406067196 424 45 8 0.177777777777778 0.0188679245283019
GO:BP GO:0002443 leukocyte mediated immunity 0.000939704441193812 877 46 11 0.239130434782609 0.0125427594070696
GO:BP GO:0042113 B cell activation 0.00122450323893421 330 60 8 0.133333333333333 0.0242424242424242
GO:BP GO:0019731 antibacterial humoral response 0.00122450323893421 62 42 4 0.0952380952380952 0.0645161290322581
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00127603661563035 323 45 7 0.155555555555556 0.021671826625387
GO:BP GO:0061024 membrane organization 0.0016764889211488 973 45 11 0.244444444444444 0.0113052415210689
GO:BP GO:0002682 regulation of immune system process 0.00177820207526074 1617 34 12 0.352941176470588 0.00742115027829314
GO:BP GO:0002449 lymphocyte mediated immunity 0.00203109018289254 354 45 7 0.155555555555556 0.019774011299435
GO:BP GO:0003094 glomerular filtration 0.00206683277060783 25 42 3 0.0714285714285714 0.12
GO:BP GO:0097205 renal filtration 0.00220656289465319 26 42 3 0.0714285714285714 0.115384615384615
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00220656289465319 363 45 7 0.155555555555556 0.0192837465564738
GO:BP GO:0016477 cell migration 0.00230339742396177 1649 88 21 0.238636363636364 0.0127349909035779
GO:BP GO:0048871 multicellular organismal homeostasis 0.0023648723802909 530 14 5 0.357142857142857 0.00943396226415094
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.0023648723802909 512 45 8 0.177777777777778 0.015625
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0023648723802909 515 45 8 0.177777777777778 0.0155339805825243
GO:BP GO:0051249 regulation of lymphocyte activation 0.00240581639682174 518 45 8 0.177777777777778 0.0154440154440154
GO:BP GO:0002250 adaptive immune response 0.0026186912448446 689 45 9 0.2 0.0130624092888244
GO:BP GO:0051674 localization of cell 0.00262626005921551 1828 88 22 0.25 0.012035010940919
GO:BP GO:0048870 cell motility 0.00262626005921551 1828 88 22 0.25 0.012035010940919
GO:BP GO:0006897 endocytosis 0.00262626005921551 696 45 9 0.2 0.0129310344827586
GO:BP GO:0006909 phagocytosis 0.00262626005921551 387 45 7 0.155555555555556 0.0180878552971576
GO:BP GO:0002376 immune system process 0.00324172321855693 3278 46 20 0.434782608695652 0.0061012812690665
GO:BP GO:0052695 cellular glucuronidation 0.00383762181281047 20 74 3 0.0405405405405405 0.15
GO:BP GO:0045321 leukocyte activation 0.00460560653085254 1332 46 12 0.260869565217391 0.00900900900900901
GO:BP GO:0043207 response to external biotic stimulus 0.00460560653085254 1594 45 13 0.288888888888889 0.0081555834378921
GO:BP GO:0051707 response to other organism 0.00460560653085254 1592 45 13 0.288888888888889 0.00816582914572864
GO:BP GO:0006952 defense response 0.00517276472137388 1818 46 14 0.304347826086957 0.0077007700770077
GO:BP GO:0001894 tissue homeostasis 0.00517276472137388 270 7 3 0.428571428571429 0.0111111111111111
GO:BP GO:0006955 immune response 0.00517276472137388 2311 46 16 0.347826086956522 0.00692340977931631
GO:BP GO:0009607 response to biotic stimulus 0.00517276472137388 1626 45 13 0.288888888888889 0.00799507995079951
GO:BP GO:0002694 regulation of leukocyte activation 0.00521359523011746 610 45 8 0.177777777777778 0.0131147540983607
GO:BP GO:0006063 uronic acid metabolic process 0.00623711143976927 25 74 3 0.0405405405405405 0.12
GO:BP GO:0019585 glucuronate metabolic process 0.00623711143976927 25 74 3 0.0405405405405405 0.12
GO:BP GO:0002757 immune response-activating signal transduction 0.00672358759934451 477 45 7 0.155555555555556 0.0146750524109015
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.00672358759934451 477 45 7 0.155555555555556 0.0146750524109015
GO:BP GO:0030449 regulation of complement activation 0.00672358759934451 110 45 4 0.0888888888888889 0.0363636363636364
GO:BP GO:0006801 superoxide metabolic process 0.0068212430389121 67 29 3 0.103448275862069 0.0447761194029851
GO:BP GO:0050865 regulation of cell activation 0.007520211046768 655 45 8 0.177777777777778 0.0122137404580153
GO:BP GO:0040011 locomotion 0.00824782926268308 2028 44 14 0.318181818181818 0.00690335305719921
GO:BP GO:0046683 response to organophosphorus 0.00904588483626246 137 40 4 0.1 0.0291970802919708
GO:BP GO:0042592 homeostatic process 0.00974359658986608 1981 85 21 0.247058823529412 0.0106007067137809
GO:BP GO:0001775 cell activation 0.00999884361682557 1495 46 12 0.260869565217391 0.00802675585284281
GO:BP GO:0002252 immune effector process 0.0110517908258211 1309 84 16 0.19047619047619 0.0122230710466005
GO:BP GO:0038093 Fc receptor signaling pathway 0.0110517908258211 238 45 5 0.111111111111111 0.0210084033613445
GO:BP GO:0048584 positive regulation of response to stimulus 0.0112763317465257 2344 54 17 0.314814814814815 0.00725255972696246
GO:BP GO:0002920 regulation of humoral immune response 0.0116444971141574 133 45 4 0.0888888888888889 0.0300751879699248
GO:BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 0.0116497200239326 135 45 4 0.0888888888888889 0.0296296296296296
GO:BP GO:0019730 antimicrobial humoral response 0.0116497200239326 145 42 4 0.0952380952380952 0.0275862068965517
GO:BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 0.0116497200239326 135 45 4 0.0888888888888889 0.0296296296296296
GO:BP GO:0014074 response to purine-containing compound 0.0116497200239326 152 40 4 0.1 0.0263157894736842
GO:BP GO:0038094 Fc-gamma receptor signaling pathway 0.0121323596147713 137 45 4 0.0888888888888889 0.0291970802919708
GO:BP GO:0009605 response to external stimulus 0.0132529018536437 2944 45 17 0.377777777777778 0.00577445652173913
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 0.0132529018536437 141 45 4 0.0888888888888889 0.0283687943262411
GO:BP GO:0051591 response to cAMP 0.0136717347233764 97 28 3 0.107142857142857 0.0309278350515464
GO:BP GO:0002253 activation of immune response 0.0141432075244187 568 45 7 0.155555555555556 0.0123239436619718
GO:BP GO:0006928 movement of cell or subcellular component 0.0146054024042499 2311 115 28 0.243478260869565 0.0121159671138035
GO:BP GO:0002685 regulation of leukocyte migration 0.0149007443616523 211 32 4 0.125 0.018957345971564
GO:BP GO:0046649 lymphocyte activation 0.0163519453400861 771 45 8 0.177777777777778 0.0103761348897536
GO:BP GO:0048583 regulation of response to stimulus 0.0172173369799366 4278 45 21 0.466666666666667 0.00490883590462833
GO:BP GO:0060249 anatomical structure homeostasis 0.0175380894413817 482 7 3 0.428571428571429 0.00622406639004149
GO:BP GO:0045087 innate immune response 0.0186692760001563 998 45 9 0.2 0.00901803607214429
GO:BP GO:0140352 export from cell 0.0186692760001563 1418 68 14 0.205882352941176 0.00987306064880113
GO:BP GO:0098542 defense response to other organism 0.0186692760001563 1218 45 10 0.222222222222222 0.00821018062397373
GO:BP GO:0050776 regulation of immune response 0.0186692760001563 996 45 9 0.2 0.00903614457831325
GO:BP GO:0010975 regulation of neuron projection development 0.019752722939505 451 79 8 0.10126582278481 0.0177383592017738
GO:BP GO:0019752 carboxylic acid metabolic process 0.0199355536012099 1024 94 14 0.148936170212766 0.013671875
GO:BP GO:0051179 localization 0.0199870290232132 6901 76 43 0.565789473684211 0.00623098101724388
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0201155175178683 1103 88 14 0.159090909090909 0.0126926563916591
GO:BP GO:0032940 secretion by cell 0.0201155175178683 1364 64 13 0.203125 0.00953079178885631
GO:BP GO:0006898 receptor-mediated endocytosis 0.0224851163197827 333 42 5 0.119047619047619 0.015015015015015
GO:BP GO:0002684 positive regulation of immune system process 0.0233393202557445 1065 45 9 0.2 0.00845070422535211
GO:BP GO:0006810 transport 0.0233393202557445 5224 76 35 0.460526315789474 0.00669984686064318
GO:BP GO:0043436 oxoacid metabolic process 0.0234936322041928 1057 94 14 0.148936170212766 0.0132450331125828
GO:BP GO:0042554 superoxide anion generation 0.0238263458525714 35 106 3 0.0283018867924528 0.0857142857142857
GO:BP GO:0006575 cellular modified amino acid metabolic process 0.0238263458525714 199 106 6 0.0566037735849057 0.0301507537688442
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0238263458525714 290 29 4 0.137931034482759 0.0137931034482759
GO:BP GO:0009636 response to toxic substance 0.0247313277257351 243 120 7 0.0583333333333333 0.0288065843621399
GO:BP GO:0032370 positive regulation of lipid transport 0.025230107073759 87 44 3 0.0681818181818182 0.0344827586206897
GO:BP GO:0006082 organic acid metabolic process 0.0282212922807924 1090 94 14 0.148936170212766 0.0128440366972477
GO:BP GO:0032787 monocarboxylic acid metabolic process 0.0288363993558105 658 105 11 0.104761904761905 0.0167173252279635
GO:BP GO:0006950 response to stress 0.0301654701142318 4170 46 20 0.434782608695652 0.00479616306954436
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0301654701142318 3210 91 28 0.307692307692308 0.00872274143302181
GO:BP GO:0051234 establishment of localization 0.0324717256136137 5372 76 35 0.460526315789474 0.00651526433358153
GO:BP GO:2000401 regulation of lymphocyte migration 0.0344581884958144 63 71 3 0.0422535211267606 0.0476190476190476
GO:BP GO:0046903 secretion 0.035118292702483 1501 64 13 0.203125 0.00866089273817455
GO:BP GO:0044281 small molecule metabolic process 0.0354345342945922 1921 95 20 0.210526315789474 0.0104112441436752
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0354345342945922 745 33 6 0.181818181818182 0.00805369127516779
GO:BP GO:0140353 lipid export from cell 0.0390495710020562 88 54 3 0.0555555555555556 0.0340909090909091
GO:BP GO:0050778 positive regulation of immune response 0.0399032066474539 753 45 7 0.155555555555556 0.00929614873837981
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0424040749444209 2255 45 13 0.288888888888889 0.0057649667405765
GO:BP GO:0040013 negative regulation of locomotion 0.0424857441088912 401 84 7 0.0833333333333333 0.0174563591022444
GO:BP GO:1905954 positive regulation of lipid localization 0.0424857441088912 113 44 3 0.0681818181818182 0.0265486725663717
GO:BP GO:0043507 positive regulation of JUN kinase activity 0.0437876714106514 71 71 3 0.0422535211267606 0.0422535211267606
GO:BP GO:0006869 lipid transport 0.0465805596953146 480 54 6 0.111111111111111 0.0125
GO:BP GO:1901570 fatty acid derivative biosynthetic process 0.0481400942666858 61 87 3 0.0344827586206897 0.0491803278688525
GO:BP GO:0003013 circulatory system process 0.0484941390898773 637 86 9 0.104651162790698 0.0141287284144427
GO:BP GO:0042445 hormone metabolic process 0.0487364154289429 228 24 3 0.125 0.0131578947368421
GO:BP GO:2000145 regulation of cell motility 0.0487364154289429 1061 128 16 0.125 0.0150801131008483
GO:BP GO:0070887 cellular response to chemical stimulus 0.0488086205652921 3393 32 13 0.40625 0.00383141762452107
GO:CC GO:0042571 immunoglobulin complex, circulating 4.52926944613707e-11 77 45 9 0.2 0.116883116883117
GO:CC GO:0071751 secretory IgA immunoglobulin complex 6.43585880389436e-09 5 42 4 0.0952380952380952 0.8
GO:CC GO:0071745 IgA immunoglobulin complex 6.43585880389436e-09 5 42 4 0.0952380952380952 0.8
GO:CC GO:0071749 polymeric IgA immunoglobulin complex 6.43585880389436e-09 5 42 4 0.0952380952380952 0.8
GO:CC GO:0071746 IgA immunoglobulin complex, circulating 6.43585880389436e-09 5 42 4 0.0952380952380952 0.8
GO:CC GO:0019814 immunoglobulin complex 8.96407487078941e-09 167 45 9 0.2 0.0538922155688623
GO:CC GO:0072562 blood microparticle 5.47757393086833e-08 140 45 8 0.177777777777778 0.0571428571428571
GO:CC GO:0031982 vesicle 2.15959353547354e-07 4055 78 40 0.512820512820513 0.00986436498150432
GO:CC GO:0071750 dimeric IgA immunoglobulin complex 3.13334743747975e-07 3 42 3 0.0714285714285714 1
GO:CC GO:0071752 secretory dimeric IgA immunoglobulin complex 3.13334743747975e-07 3 42 3 0.0714285714285714 1
GO:CC GO:0070062 extracellular exosome 4.29387157578132e-07 2176 78 28 0.358974358974359 0.0128676470588235
GO:CC GO:0043230 extracellular organelle 8.55899127908569e-07 2263 78 28 0.358974358974359 0.0123729562527618
GO:CC GO:1903561 extracellular vesicle 8.55899127908569e-07 2261 78 28 0.358974358974359 0.0123839009287926
GO:CC GO:0071748 monomeric IgA immunoglobulin complex 8.93860797138744e-07 4 42 3 0.0714285714285714 0.75
GO:CC GO:0005615 extracellular space 3.42329211343363e-05 3594 8 8 1 0.00222593210907067
GO:CC GO:0009897 external side of plasma membrane 7.51920066593898e-05 408 45 8 0.177777777777778 0.0196078431372549
GO:CC GO:0009986 cell surface 9.14837988687487e-05 899 45 11 0.244444444444444 0.0122358175750834
GO:CC GO:0005576 extracellular region 0.000166517999142829 4567 8 8 1 0.00175169695642654
GO:CC GO:0043020 NADPH oxidase complex 0.000507572845767314 12 106 3 0.0283018867924528 0.25
GO:CC GO:0035577 azurophil granule membrane 0.00108034440754263 57 76 4 0.0526315789473684 0.0701754385964912
GO:CC GO:0098552 side of membrane 0.00118074410019017 619 45 8 0.177777777777778 0.012924071082391
GO:CC GO:0031410 cytoplasmic vesicle 0.00501799480044948 2424 76 21 0.276315789473684 0.00866336633663366
GO:CC GO:0097708 intracellular vesicle 0.00501799480044948 2428 76 21 0.276315789473684 0.00864909390444811
GO:CC GO:0016324 apical plasma membrane 0.0181591493861864 361 13 3 0.230769230769231 0.00831024930747922
GO:CC GO:0098852 lytic vacuole membrane 0.0183475256288108 383 13 3 0.230769230769231 0.00783289817232376
GO:CC GO:0005886 plasma membrane 0.0183475256288108 5681 86 39 0.453488372093023 0.0068649885583524
GO:CC GO:0005765 lysosomal membrane 0.0183475256288108 383 13 3 0.230769230769231 0.00783289817232376
GO:CC GO:0016021 integral component of membrane 0.0183475256288108 5711 124 53 0.42741935483871 0.00928033619331115
GO:CC GO:0045177 apical part of cell 0.0243043676587979 431 13 3 0.230769230769231 0.00696055684454756
GO:CC GO:0071944 cell periphery 0.0244555145957468 6169 57 29 0.508771929824561 0.00470092397471227
GO:CC GO:0005774 vacuolar membrane 0.0244555145957468 441 13 3 0.230769230769231 0.00680272108843537
GO:CC GO:0042582 azurophil granule 0.0246029891390338 154 76 4 0.0526315789473684 0.025974025974026
GO:CC GO:0005766 primary lysosome 0.0246029891390338 154 76 4 0.0526315789473684 0.025974025974026
GO:CC GO:0005887 integral component of plasma membrane 0.0246029891390338 1645 120 20 0.166666666666667 0.0121580547112462
GO:CC GO:0031224 intrinsic component of membrane 0.0252624220307991 5868 124 53 0.42741935483871 0.00903203817314247
GO:CC GO:0005769 early endosome 0.029352304292427 378 54 5 0.0925925925925926 0.0132275132275132
GO:CC GO:0016020 membrane 0.0316502794481777 9838 46 33 0.717391304347826 0.00335434031307176
GO:CC GO:0055037 recycling endosome 0.0316502794481777 188 69 4 0.0579710144927536 0.0212765957446809
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0366033198720096 1726 120 20 0.166666666666667 0.0115874855156431
GO:CC GO:0005796 Golgi lumen 0.0378509010550275 99 71 3 0.0422535211267606 0.0303030303030303
GO:CC GO:0098984 neuron to neuron synapse 0.0388650036050655 366 86 6 0.0697674418604651 0.0163934426229508
GO:CC GO:0005768 endosome 0.0495316410178268 987 69 9 0.130434782608696 0.00911854103343465
GO:MF GO:0034987 immunoglobulin receptor binding 6.37541316483247e-09 79 45 8 0.177777777777778 0.10126582278481
GO:MF GO:0003823 antigen binding 1.09324397017743e-06 163 45 8 0.177777777777778 0.049079754601227
GO:MF GO:0016175 superoxide-generating NAD(P)H oxidase activity 0.00445388443180968 11 106 3 0.0283018867924528 0.272727272727273
GO:MF GO:0031210 phosphatidylcholine binding 0.00633778692679018 31 49 3 0.0612244897959184 0.0967741935483871
GO:MF GO:0005102 signaling receptor binding 0.00633778692679018 1672 45 13 0.288888888888889 0.00777511961722488
GO:MF GO:0050997 quaternary ammonium group binding 0.00633778692679018 31 49 3 0.0612244897959184 0.0967741935483871
GO:MF GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor 0.00633778692679018 16 106 3 0.0283018867924528 0.1875
GO:MF GO:0016757 transferase activity, transferring glycosyl groups 0.00738981658702297 283 103 8 0.0776699029126214 0.0282685512367491
GO:MF GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 0.0118525790694906 57 106 4 0.0377358490566038 0.0701754385964912
GO:MF GO:0015020 glucuronosyltransferase activity 0.0118525790694906 34 74 3 0.0405405405405405 0.0882352941176471
GO:MF GO:0003824 catalytic activity 0.012826729508945 5896 87 43 0.494252873563218 0.00729308005427408
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.0163926965088858 107 29 3 0.103448275862069 0.0280373831775701
GO:MF GO:0016758 transferase activity, transferring hexosyl groups 0.0181036830374517 205 103 6 0.058252427184466 0.0292682926829268
GO:MF GO:0008194 UDP-glycosyltransferase activity 0.0209675977155178 146 103 5 0.0485436893203883 0.0342465753424658
GO:MF GO:0005539 glycosaminoglycan binding 0.0237264986014589 238 19 3 0.157894736842105 0.0126050420168067
GO:MF GO:0016491 oxidoreductase activity 0.0278477742975488 771 33 6 0.181818181818182 0.00778210116731518
GO:MF GO:0005125 cytokine activity 0.0326865865310028 235 22 3 0.136363636363636 0.0127659574468085
GO:MF GO:0097367 carbohydrate derivative binding 0.0336260441207964 2285 68 17 0.25 0.0074398249452954
GO:MF GO:0004601 peroxidase activity 0.0354618855776749 53 106 3 0.0283018867924528 0.0566037735849057
GO:MF GO:0000166 nucleotide binding 0.038279648441086 2171 68 16 0.235294117647059 0.00736987563334869
GO:MF GO:1901265 nucleoside phosphate binding 0.038279648441086 2172 68 16 0.235294117647059 0.00736648250460405
GO:MF GO:0005543 phospholipid binding 0.038279648441086 454 84 7 0.0833333333333333 0.0154185022026432
GO:MF GO:0005126 cytokine receptor binding 0.038279648441086 275 22 3 0.136363636363636 0.0109090909090909
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 0.0418131381423408 1847 68 14 0.205882352941176 0.00757985923118571
GO:MF GO:0005524 ATP binding 0.0475362326010696 1501 68 12 0.176470588235294 0.00799467021985343
GO:MF GO:0032555 purine ribonucleotide binding 0.0496826855478477 1918 68 14 0.205882352941176 0.0072992700729927
REAC REAC:R-HSA-2168880 Scavenging of heme from plasma 0.00228676923764532 67 42 5 0.119047619047619 0.0746268656716418
REAC REAC:R-HSA-2173782 Binding and Uptake of Ligands by Scavenger Receptors 0.00631954216773827 95 42 5 0.119047619047619 0.0526315789473684
REAC REAC:R-HSA-173623 Classical antibody-mediated complement activation 0.0114531279455723 61 45 4 0.0888888888888889 0.0655737704918033
REAC REAC:R-HSA-202733 Cell surface interactions at the vascular wall 0.0114531279455723 190 42 6 0.142857142857143 0.0315789473684211
REAC REAC:R-HSA-2029481 FCGR activation 0.0116591755035853 67 45 4 0.0888888888888889 0.0597014925373134
REAC REAC:R-HSA-166786 Creation of C4 and C2 activators 0.0116591755035853 68 45 4 0.0888888888888889 0.0588235294117647
REAC REAC:R-HSA-9658195 Leishmania infection 0.0139721352510758 303 46 7 0.152173913043478 0.0231023102310231
REAC REAC:R-HSA-166663 Initial triggering of complement 0.0139721352510758 76 45 4 0.0888888888888889 0.0526315789473684
REAC REAC:R-HSA-2029485 Role of phospholipids in phagocytosis 0.0152511357263584 81 45 4 0.0888888888888889 0.0493827160493827
REAC REAC:R-HSA-156588 Glucuronidation 0.0192381185374654 23 74 3 0.0405405405405405 0.130434782608696
REAC REAC:R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.0210979751376268 93 45 4 0.0888888888888889 0.043010752688172
REAC REAC:R-HSA-211859 Biological oxidations 0.0243526025165821 215 37 5 0.135135135135135 0.0232558139534884
REAC REAC:R-HSA-977606 Regulation of Complement cascade 0.0243526025165821 101 45 4 0.0888888888888889 0.0396039603960396
REAC REAC:R-HSA-5690714 CD22 mediated BCR regulation 0.0250973381604873 61 34 3 0.0882352941176471 0.0491803278688525
REAC REAC:R-HSA-9664422 FCGR3A-mediated phagocytosis 0.0267237301927005 113 45 4 0.0888888888888889 0.0353982300884956
REAC REAC:R-HSA-9664407 Parasite infection 0.0267237301927005 113 45 4 0.0888888888888889 0.0353982300884956
REAC REAC:R-HSA-166658 Complement cascade 0.0267237301927005 111 45 4 0.0888888888888889 0.036036036036036
REAC REAC:R-HSA-9664417 Leishmania phagocytosis 0.0267237301927005 113 45 4 0.0888888888888889 0.0353982300884956
REAC REAC:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.0278938076586265 116 45 4 0.0888888888888889 0.0344827586206897
REAC REAC:R-HSA-156580 Phase II - Conjugation of compounds 0.0338253452293428 104 26 3 0.115384615384615 0.0288461538461538
REAC REAC:R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 0.0363257622397415 85 34 3 0.0882352941176471 0.0352941176470588
REAC REAC:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.0363257622397415 140 45 4 0.0888888888888889 0.0285714285714286
REAC REAC:R-HSA-9664433 Leishmania parasite growth and survival 0.0363257622397415 221 46 5 0.108695652173913 0.0226244343891403
REAC REAC:R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.0363257622397415 221 46 5 0.108695652173913 0.0226244343891403

pEpi31 transcription factor target enrichment of top program genes

TF enrichment of pEpi31
Possible regulators of activation of pEpi31 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.