pS15 program activity among Stromal cells

Activation of pS15
pS15 gene program activation in Stromal cells.
Gene program activation of pS15 by different cell subtypes
pS15 gene program activation among cells of different subtypes (Stromal cells).

pS15 top program genes

Top genes of pS15 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS15 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS15
pS15 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0072359 circulatory system development 2.46656665352294e-05 1194 68 20 0.294117647058824 0.016750418760469
GO:BP GO:0009653 anatomical structure morphogenesis 2.54747139369766e-05 2797 68 30 0.441176470588235 0.0107257776188774
GO:BP GO:0001568 blood vessel development 2.75095301536178e-05 792 68 16 0.235294117647059 0.0202020202020202
GO:BP GO:0001944 vasculature development 3.95411421509646e-05 830 68 16 0.235294117647059 0.0192771084337349
GO:BP GO:0023052 signaling 0.00023582199126775 6810 141 82 0.581560283687943 0.0120411160058737
GO:BP GO:0003013 circulatory system process 0.00023582199126775 637 140 19 0.135714285714286 0.0298273155416013
GO:BP GO:0008015 blood circulation 0.00023582199126775 553 43 10 0.232558139534884 0.0180831826401447
GO:BP GO:0007507 heart development 0.000455105424394125 578 45 10 0.222222222222222 0.0173010380622837
GO:BP GO:0048514 blood vessel morphogenesis 0.000632293080796595 711 39 10 0.256410256410256 0.0140646976090014
GO:BP GO:0032502 developmental process 0.000649347102132822 6628 82 51 0.621951219512195 0.00769462884731442
GO:BP GO:0035295 tube development 0.000714504347554233 1146 39 12 0.307692307692308 0.0104712041884817
GO:BP GO:0065009 regulation of molecular function 0.000714504347554233 3221 143 48 0.335664335664336 0.0149022042843837
GO:BP GO:0048856 anatomical structure development 0.000714504347554233 6106 144 75 0.520833333333333 0.0122830003275467
GO:BP GO:0007154 cell communication 0.000714504347554233 6829 141 80 0.567375886524823 0.0117147459364475
GO:BP GO:0030029 actin filament-based process 0.000714504347554233 808 140 20 0.142857142857143 0.0247524752475248
GO:BP GO:0032835 glomerulus development 0.000714504347554233 62 32 4 0.125 0.0645161290322581
GO:BP GO:0035239 tube morphogenesis 0.000714504347554233 950 39 11 0.282051282051282 0.0115789473684211
GO:BP GO:0003084 positive regulation of systemic arterial blood pressure 0.000731529539951079 17 123 4 0.032520325203252 0.235294117647059
GO:BP GO:0032501 multicellular organismal process 0.00102448360024203 7946 82 56 0.682926829268293 0.00704757110495847
GO:BP GO:0060485 mesenchyme development 0.00128405184437234 291 107 10 0.0934579439252336 0.0343642611683849
GO:BP GO:0001822 kidney development 0.00151389502701683 293 32 6 0.1875 0.0204778156996587
GO:BP GO:0007275 multicellular organism development 0.00151389502701683 5613 138 67 0.485507246376812 0.0119365758061643
GO:BP GO:0000902 cell morphogenesis 0.00151460620479582 1037 138 22 0.159420289855072 0.0212150433944069
GO:BP GO:0072001 renal system development 0.00158770165707861 302 32 6 0.1875 0.0198675496688742
GO:BP GO:0007155 cell adhesion 0.00173734338099187 1492 136 27 0.198529411764706 0.0180965147453083
GO:BP GO:0023051 regulation of signaling 0.00175464647095863 3578 136 48 0.352941176470588 0.0134153158188932
GO:BP GO:0022610 biological adhesion 0.00175464647095863 1499 136 27 0.198529411764706 0.0180120080053369
GO:BP GO:0010922 positive regulation of phosphatase activity 0.00179534284823911 34 27 3 0.111111111111111 0.0882352941176471
GO:BP GO:0003012 muscle system process 0.00179534284823911 471 140 14 0.1 0.029723991507431
GO:BP GO:0031589 cell-substrate adhesion 0.00211930990483419 367 136 12 0.0882352941176471 0.0326975476839237
GO:BP GO:0003018 vascular process in circulatory system 0.00223541628214016 256 136 10 0.0735294117647059 0.0390625
GO:BP GO:0001655 urogenital system development 0.00223541628214016 337 32 6 0.1875 0.0178041543026706
GO:BP GO:0006936 muscle contraction 0.0022418720314759 364 140 12 0.0857142857142857 0.032967032967033
GO:BP GO:0030198 extracellular matrix organization 0.0022418720314759 401 128 12 0.09375 0.029925187032419
GO:BP GO:0043062 extracellular structure organization 0.0022418720314759 402 128 12 0.09375 0.0298507462686567
GO:BP GO:0045229 external encapsulating structure organization 0.00229439970136821 404 128 12 0.09375 0.0297029702970297
GO:BP GO:0010646 regulation of cell communication 0.00241567301375922 3543 133 46 0.345864661654135 0.0129833474456675
GO:BP GO:0007165 signal transduction 0.00310155919902767 6309 131 68 0.519083969465649 0.0107782532889523
GO:BP GO:0030036 actin cytoskeleton organization 0.00318617236162227 709 129 16 0.124031007751938 0.0225669957686883
GO:BP GO:0033993 response to lipid 0.00321590200213943 918 134 19 0.141791044776119 0.0206971677559913
GO:BP GO:0150104 transport across blood-brain barrier 0.00328925409597209 87 136 6 0.0441176470588235 0.0689655172413793
GO:BP GO:0050790 regulation of catalytic activity 0.00328925409597209 2545 127 35 0.275590551181102 0.0137524557956778
GO:BP GO:0010232 vascular transport 0.00328925409597209 88 136 6 0.0441176470588235 0.0681818181818182
GO:BP GO:0000904 cell morphogenesis involved in differentiation 0.00328925409597209 749 138 17 0.123188405797101 0.0226969292389853
GO:BP GO:0014706 striated muscle tissue development 0.00328925409597209 380 33 6 0.181818181818182 0.0157894736842105
GO:BP GO:0016043 cellular component organization 0.00328925409597209 6566 141 74 0.524822695035461 0.0112701797136765
GO:BP GO:0003073 regulation of systemic arterial blood pressure 0.00364603741621877 101 123 6 0.0487804878048781 0.0594059405940594
GO:BP GO:0060537 muscle tissue development 0.00404852201458841 399 33 6 0.181818181818182 0.0150375939849624
GO:BP GO:0048762 mesenchymal cell differentiation 0.00404852201458841 234 107 8 0.0747663551401869 0.0341880341880342
GO:BP GO:0010721 negative regulation of cell development 0.00430196654453071 183 138 8 0.0579710144927536 0.0437158469945355
GO:BP GO:0035306 positive regulation of dephosphorylation 0.00451797307406566 58 27 3 0.111111111111111 0.0517241379310345
GO:BP GO:0001525 angiogenesis 0.00454898020646709 617 68 10 0.147058823529412 0.0162074554294976
GO:BP GO:0006935 chemotaxis 0.00454898020646709 653 133 15 0.112781954887218 0.0229709035222052
GO:BP GO:0014033 neural crest cell differentiation 0.00454898020646709 90 92 5 0.0543478260869565 0.0555555555555556
GO:BP GO:0014031 mesenchymal cell development 0.00454898020646709 84 98 5 0.0510204081632653 0.0595238095238095
GO:BP GO:0042330 taxis 0.00454898020646709 656 133 15 0.112781954887218 0.0228658536585366
GO:BP GO:0048523 negative regulation of cellular process 0.00470329210341325 5139 138 60 0.434782608695652 0.0116754232340922
GO:BP GO:0006928 movement of cell or subcellular component 0.00482863764225373 2311 144 35 0.243055555555556 0.0151449588922544
GO:BP GO:1901700 response to oxygen-containing compound 0.00482863764225373 1739 138 28 0.202898550724638 0.0161012075905693
GO:BP GO:0072006 nephron development 0.0049134741002582 142 32 4 0.125 0.028169014084507
GO:BP GO:0003008 system process 0.00509910999413357 2293 140 34 0.242857142857143 0.0148277365896206
GO:BP GO:0043085 positive regulation of catalytic activity 0.00535872071092145 1418 127 23 0.181102362204724 0.0162200282087447
GO:BP GO:0044706 multi-multicellular organism process 0.00547000617868392 227 89 7 0.0786516853932584 0.0308370044052863
GO:BP GO:0007566 embryo implantation 0.00604018013802106 54 89 4 0.0449438202247191 0.0740740740740741
GO:BP GO:0071840 cellular component organization or biogenesis 0.00682452944748624 6760 141 74 0.524822695035461 0.0109467455621302
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.00689483489306439 1202 39 10 0.256410256410256 0.00831946755407654
GO:BP GO:0009966 regulation of signal transduction 0.00689483489306439 3165 131 40 0.305343511450382 0.0126382306477093
GO:BP GO:0045777 positive regulation of blood pressure 0.00735021784312919 42 123 4 0.032520325203252 0.0952380952380952
GO:BP GO:0040008 regulation of growth 0.0078668463574776 681 137 15 0.109489051094891 0.0220264317180617
GO:BP GO:0048667 cell morphogenesis involved in neuron differentiation 0.00787532706361184 602 138 14 0.101449275362319 0.0232558139534884
GO:BP GO:0048468 cell development 0.00787532706361184 2100 138 31 0.22463768115942 0.0147619047619048
GO:BP GO:0014070 response to organic cyclic compound 0.00795742253969906 967 32 8 0.25 0.00827300930713547
GO:BP GO:0051128 regulation of cellular component organization 0.00841735681840191 2412 138 34 0.246376811594203 0.0140961857379768
GO:BP GO:0007219 Notch signaling pathway 0.00843831822002504 193 115 7 0.0608695652173913 0.0362694300518135
GO:BP GO:0043549 regulation of kinase activity 0.00861331863145575 921 127 17 0.133858267716535 0.0184581976112921
GO:BP GO:0043406 positive regulation of MAP kinase activity 0.00875466450214226 234 96 7 0.0729166666666667 0.0299145299145299
GO:BP GO:0007565 female pregnancy 0.00891854440912511 198 52 5 0.0961538461538462 0.0252525252525253
GO:BP GO:0048731 system development 0.00899353963224298 5052 63 31 0.492063492063492 0.00613618368962787
GO:BP GO:0030155 regulation of cell adhesion 0.00899353963224298 748 128 15 0.1171875 0.0200534759358289
GO:BP GO:0048699 generation of neurons 0.00909152028093487 1559 138 25 0.181159420289855 0.0160359204618345
GO:BP GO:1902531 regulation of intracellular signal transduction 0.00909152028093487 1842 131 27 0.206106870229008 0.0146579804560261
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.00909152028093487 760 127 15 0.118110236220472 0.0197368421052632
GO:BP GO:0043405 regulation of MAP kinase activity 0.00909152028093487 316 96 8 0.0833333333333333 0.0253164556962025
GO:BP GO:0050921 positive regulation of chemotaxis 0.00909152028093487 141 74 5 0.0675675675675676 0.0354609929078014
GO:BP GO:0050793 regulation of developmental process 0.0094907626853891 2605 110 30 0.272727272727273 0.0115163147792706
GO:BP GO:0007399 nervous system development 0.00953180176618926 2449 138 34 0.246376811594203 0.013883217639853
GO:BP GO:0051897 positive regulation of protein kinase B signaling 0.0097583233625093 184 127 7 0.0551181102362205 0.0380434782608696
GO:BP GO:0086002 cardiac muscle cell action potential involved in contraction 0.0097583233625093 56 43 3 0.0697674418604651 0.0535714285714286
GO:BP GO:0044093 positive regulation of molecular function 0.0100248688466776 1771 138 27 0.195652173913043 0.0152456239412761
GO:BP GO:0022008 neurogenesis 0.0100248688466776 1675 138 26 0.188405797101449 0.0155223880597015
GO:BP GO:0048863 stem cell differentiation 0.0100248688466776 258 92 7 0.0760869565217391 0.0271317829457364
GO:BP GO:0003151 outflow tract morphogenesis 0.0100248688466776 75 33 3 0.0909090909090909 0.04
GO:BP GO:0008217 regulation of blood pressure 0.0100248688466776 193 123 7 0.0569105691056911 0.0362694300518135
GO:BP GO:0051056 regulation of small GTPase mediated signal transduction 0.0101568917960647 328 121 9 0.0743801652892562 0.0274390243902439
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.0108206682505195 385 127 10 0.078740157480315 0.025974025974026
GO:BP GO:0007413 axonal fasciculation 0.011005980805496 20 133 3 0.0225563909774436 0.15
GO:BP GO:0106030 neuron projection fasciculation 0.011005980805496 20 133 3 0.0225563909774436 0.15
GO:BP GO:0060047 heart contraction 0.011005980805496 288 140 9 0.0642857142857143 0.03125
GO:BP GO:0051239 regulation of multicellular organismal process 0.011005980805496 2861 140 38 0.271428571428571 0.0132820692065711
GO:BP GO:0018212 peptidyl-tyrosine modification 0.011005980805496 388 127 10 0.078740157480315 0.0257731958762887
GO:BP GO:0051145 smooth muscle cell differentiation 0.0110160346364683 80 142 5 0.0352112676056338 0.0625
GO:BP GO:0048008 platelet-derived growth factor receptor signaling pathway 0.0118103816002623 59 112 4 0.0357142857142857 0.0677966101694915
GO:BP GO:0032526 response to retinoic acid 0.0118103816002623 110 107 5 0.0467289719626168 0.0454545454545455
GO:BP GO:0045445 myoblast differentiation 0.0118103816002623 84 33 3 0.0909090909090909 0.0357142857142857
GO:BP GO:0040011 locomotion 0.0118103816002623 2028 136 29 0.213235294117647 0.0142998027613412
GO:BP GO:0086009 membrane repolarization 0.0120465578541001 48 140 4 0.0285714285714286 0.0833333333333333
GO:BP GO:0035556 intracellular signal transduction 0.0120489543430982 2772 131 35 0.267175572519084 0.0126262626262626
GO:BP GO:0003015 heart process 0.0121254366728142 298 140 9 0.0642857142857143 0.0302013422818792
GO:BP GO:0045859 regulation of protein kinase activity 0.0125523754353594 809 127 15 0.118110236220472 0.0185414091470952
GO:BP GO:0048812 neuron projection morphogenesis 0.012603799880469 664 138 14 0.101449275362319 0.0210843373493976
GO:BP GO:1903522 regulation of blood circulation 0.0127425411244483 301 140 9 0.0642857142857143 0.0299003322259136
GO:BP GO:0008283 cell population proliferation 0.0128092158713221 2054 81 20 0.246913580246914 0.00973709834469328
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 0.0148029707374111 678 138 14 0.101449275362319 0.0206489675516224
GO:BP GO:0031175 neuron projection development 0.0148029707374111 1012 138 18 0.130434782608696 0.0177865612648221
GO:BP GO:0048738 cardiac muscle tissue development 0.0151866318673974 224 33 4 0.121212121212121 0.0178571428571429
GO:BP GO:0009888 tissue development 0.0152448324085459 2107 58 16 0.275862068965517 0.007593735168486
GO:BP GO:0048858 cell projection morphogenesis 0.0152451992739363 682 138 14 0.101449275362319 0.0205278592375367
GO:BP GO:0042127 regulation of cell population proliferation 0.0156135956243501 1774 137 26 0.18978102189781 0.0146561443066516
GO:BP GO:0086003 cardiac muscle cell contraction 0.0156984097573064 75 43 3 0.0697674418604651 0.04
GO:BP GO:0001667 ameboidal-type cell migration 0.015992349876392 494 128 11 0.0859375 0.0222672064777328
GO:BP GO:0008016 regulation of heart contraction 0.0162970286927969 254 140 8 0.0571428571428571 0.031496062992126
GO:BP GO:0086001 cardiac muscle cell action potential 0.0162970286927969 77 43 3 0.0697674418604651 0.038961038961039
GO:BP GO:0050768 negative regulation of neurogenesis 0.0162970286927969 143 138 6 0.0434782608695652 0.041958041958042
GO:BP GO:0003203 endocardial cushion morphogenesis 0.0162970286927969 34 98 3 0.0306122448979592 0.0882352941176471
GO:BP GO:0030154 cell differentiation 0.0163561288089685 4350 138 50 0.36231884057971 0.0114942528735632
GO:BP GO:0060429 epithelium development 0.0165334425460206 1325 58 12 0.206896551724138 0.00905660377358491
GO:BP GO:0035909 aorta morphogenesis 0.0168956826631762 35 98 3 0.0306122448979592 0.0857142857142857
GO:BP GO:0060191 regulation of lipase activity 0.0168956826631762 101 77 4 0.051948051948052 0.0396039603960396
GO:BP GO:0051338 regulation of transferase activity 0.0168956826631762 1035 127 17 0.133858267716535 0.0164251207729469
GO:BP GO:0032990 cell part morphogenesis 0.0168956826631762 699 138 14 0.101449275362319 0.0200286123032904
GO:BP GO:0030203 glycosaminoglycan metabolic process 0.0168956826631762 159 127 6 0.047244094488189 0.0377358490566038
GO:BP GO:0010863 positive regulation of phospholipase C activity 0.0170566150550436 46 77 3 0.038961038961039 0.0652173913043478
GO:BP GO:0060284 regulation of cell development 0.0170566150550436 502 110 10 0.0909090909090909 0.0199203187250996
GO:BP GO:0061061 muscle structure development 0.0170566150550436 645 33 6 0.181818181818182 0.00930232558139535
GO:BP GO:0033674 positive regulation of kinase activity 0.0170566150550436 608 107 11 0.102803738317757 0.0180921052631579
GO:BP GO:0051961 negative regulation of nervous system development 0.0170566150550436 148 138 6 0.0434782608695652 0.0405405405405405
GO:BP GO:0006024 glycosaminoglycan biosynthetic process 0.0170566150550436 107 127 5 0.0393700787401575 0.0467289719626168
GO:BP GO:0040007 growth 0.0172698344557966 967 137 17 0.124087591240876 0.0175801447776629
GO:BP GO:0032989 cellular component morphogenesis 0.017446977495388 791 138 15 0.108695652173913 0.0189633375474083
GO:BP GO:0050920 regulation of chemotaxis 0.017446977495388 226 92 6 0.0652173913043478 0.0265486725663717
GO:BP GO:0060045 positive regulation of cardiac muscle cell proliferation 0.017530835258362 37 98 3 0.0306122448979592 0.0810810810810811
GO:BP GO:0035637 multicellular organismal signaling 0.0175874325500143 204 140 7 0.05 0.0343137254901961
GO:BP GO:0003158 endothelium development 0.0178962716283342 143 98 5 0.0510204081632653 0.034965034965035
GO:BP GO:1900274 regulation of phospholipase C activity 0.0183918980648454 48 77 3 0.038961038961039 0.0625
GO:BP GO:0007411 axon guidance 0.0190053285473475 283 133 8 0.0601503759398496 0.0282685512367491
GO:BP GO:0016477 cell migration 0.0190053285473475 1649 128 23 0.1796875 0.0139478471801092
GO:BP GO:0097485 neuron projection guidance 0.0191270817515753 284 133 8 0.0601503759398496 0.028169014084507
GO:BP GO:0051716 cellular response to stimulus 0.0191270817515753 7781 131 74 0.564885496183206 0.00951034571391852
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0191319599297027 1160 127 18 0.141732283464567 0.0155172413793103
GO:BP GO:0009187 cyclic nucleotide metabolic process 0.0191319599297027 41 93 3 0.032258064516129 0.0731707317073171
GO:BP GO:0032956 regulation of actin cytoskeleton organization 0.019386250632516 366 129 9 0.0697674418604651 0.0245901639344262
GO:BP GO:0006023 aminoglycan biosynthetic process 0.019386250632516 114 127 5 0.0393700787401575 0.043859649122807
GO:BP GO:0048869 cellular developmental process 0.0195156793128892 4428 138 50 0.36231884057971 0.0112917795844625
GO:BP GO:0099625 ventricular cardiac muscle cell membrane repolarization 0.0196524590490302 28 140 3 0.0214285714285714 0.107142857142857
GO:BP GO:0003206 cardiac chamber morphogenesis 0.0199718631514911 120 33 3 0.0909090909090909 0.025
GO:BP GO:0006939 smooth muscle contraction 0.0199831179121152 110 134 5 0.0373134328358209 0.0454545454545455
GO:BP GO:1903510 mucopolysaccharide metabolic process 0.0199831179121152 116 127 5 0.0393700787401575 0.0431034482758621
GO:BP GO:0006022 aminoglycan metabolic process 0.020303997769892 173 127 6 0.047244094488189 0.0346820809248555
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.0203170458935287 503 96 9 0.09375 0.0178926441351889
GO:BP GO:0045860 positive regulation of protein kinase activity 0.0209753901870884 534 74 8 0.108108108108108 0.0149812734082397
GO:BP GO:0051493 regulation of cytoskeleton organization 0.0209753901870884 531 129 11 0.0852713178294574 0.0207156308851224
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0209753901870884 783 102 12 0.117647058823529 0.0153256704980843
GO:BP GO:0007389 pattern specification process 0.0209753901870884 442 35 5 0.142857142857143 0.0113122171945701
GO:BP GO:0009887 animal organ morphogenesis 0.0209753901870884 1073 56 10 0.178571428571429 0.00931966449207828
GO:BP GO:0071902 positive regulation of protein serine/threonine kinase activity 0.0209753901870884 316 96 7 0.0729166666666667 0.0221518987341772
GO:BP GO:0061564 axon development 0.0224629899156096 523 133 11 0.0827067669172932 0.0210325047801147
GO:BP GO:0033002 muscle cell proliferation 0.0225249774286833 244 127 7 0.0551181102362205 0.0286885245901639
GO:BP GO:0060326 cell chemotaxis 0.0225249774286833 310 74 6 0.0810810810810811 0.0193548387096774
GO:BP GO:0003197 endocardial cushion development 0.0231592675241279 44 98 3 0.0306122448979592 0.0681818181818182
GO:BP GO:0050767 regulation of neurogenesis 0.0233220653036974 366 110 8 0.0727272727272727 0.0218579234972678
GO:BP GO:0006812 cation transport 0.0235107971350357 1197 9 4 0.444444444444444 0.00334168755221387
GO:BP GO:0010594 regulation of endothelial cell migration 0.0235107971350357 244 39 4 0.102564102564103 0.0163934426229508
GO:BP GO:0007264 small GTPase mediated signal transduction 0.0236649864444085 515 137 11 0.0802919708029197 0.0213592233009709
GO:BP GO:0050919 negative chemotaxis 0.0236649864444085 48 92 3 0.0326086956521739 0.0625
GO:BP GO:0098655 cation transmembrane transport 0.0237544644612415 914 140 16 0.114285714285714 0.0175054704595186
GO:BP GO:0034765 regulation of ion transmembrane transport 0.0239661933630001 583 140 12 0.0857142857142857 0.0205831903945112
GO:BP GO:0030030 cell projection organization 0.0241217707396822 1609 144 24 0.166666666666667 0.0149160969546302
GO:BP GO:0007010 cytoskeleton organization 0.0241867573939875 1423 144 22 0.152777777777778 0.0154602951510892
GO:BP GO:0055023 positive regulation of cardiac muscle tissue growth 0.0244342384679418 46 98 3 0.0306122448979592 0.0652173913043478
GO:BP GO:0003007 heart morphogenesis 0.024698130195984 251 39 4 0.102564102564103 0.0159362549800797
GO:BP GO:0048870 cell motility 0.0248774636544125 1828 128 24 0.1875 0.0131291028446389
GO:BP GO:0034762 regulation of transmembrane transport 0.0248774636544125 588 140 12 0.0857142857142857 0.0204081632653061
GO:BP GO:0051674 localization of cell 0.0248774636544125 1828 128 24 0.1875 0.0131291028446389
GO:BP GO:0048568 embryonic organ development 0.025318473981906 432 56 6 0.107142857142857 0.0138888888888889
GO:BP GO:0001990 regulation of systemic arterial blood pressure by hormone 0.0256125715570517 38 123 3 0.024390243902439 0.0789473684210526
GO:BP GO:0071398 cellular response to fatty acid 0.0262732772366644 43 110 3 0.0272727272727273 0.0697674418604651
GO:BP GO:0014910 regulation of smooth muscle cell migration 0.0263429245515414 85 56 3 0.0535714285714286 0.0352941176470588
GO:BP GO:0030182 neuron differentiation 0.0263429245515414 1412 138 21 0.152173913043478 0.0148725212464589
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0263429245515414 1103 130 17 0.130769230769231 0.0154125113327289
GO:BP GO:0051896 regulation of protein kinase B signaling 0.0264775746571647 259 127 7 0.0551181102362205 0.027027027027027
GO:BP GO:0010921 regulation of phosphatase activity 0.0266063697151869 180 27 3 0.111111111111111 0.0166666666666667
GO:BP GO:0001656 metanephros development 0.0267390702206227 86 56 3 0.0535714285714286 0.0348837209302326
GO:BP GO:0010765 positive regulation of sodium ion transport 0.0272844819364065 35 140 3 0.0214285714285714 0.0857142857142857
GO:BP GO:0051347 positive regulation of transferase activity 0.0272844819364065 689 107 11 0.102803738317757 0.0159651669085631
GO:BP GO:0032970 regulation of actin filament-based process 0.0272844819364065 406 129 9 0.0697674418604651 0.0221674876847291
GO:BP GO:0045595 regulation of cell differentiation 0.0272844819364065 1679 110 20 0.181818181818182 0.0119118522930316
GO:BP GO:0048519 negative regulation of biological process 0.0272844819364065 5757 138 60 0.434782608695652 0.0104220948410631
GO:BP GO:0060421 positive regulation of heart growth 0.0272844819364065 50 98 3 0.0306122448979592 0.06
GO:BP GO:0008360 regulation of cell shape 0.0272844819364065 154 67 4 0.0597014925373134 0.025974025974026
GO:BP GO:0014855 striated muscle cell proliferation 0.0272844819364065 81 127 4 0.031496062992126 0.0493827160493827
GO:BP GO:0045596 negative regulation of cell differentiation 0.0277160654463602 697 138 13 0.0942028985507246 0.0186513629842181
GO:BP GO:0072132 mesenchyme morphogenesis 0.0279365396590135 51 98 3 0.0306122448979592 0.0588235294117647
GO:BP GO:0045927 positive regulation of growth 0.0281347383856599 274 123 7 0.0569105691056911 0.0255474452554745
GO:BP GO:0007517 muscle organ development 0.0281347383856599 333 32 4 0.125 0.012012012012012
GO:BP GO:0007601 visual perception 0.0283137172911311 214 24 3 0.125 0.014018691588785
GO:BP GO:0007519 skeletal muscle tissue development 0.0284104321083767 160 32 3 0.09375 0.01875
GO:BP GO:0048666 neuron development 0.0284104321083767 1149 138 18 0.130434782608696 0.0156657963446475
GO:BP GO:0007409 axonogenesis 0.0284104321083767 478 133 10 0.075187969924812 0.0209205020920502
GO:BP GO:0035051 cardiocyte differentiation 0.0286793522048574 157 33 3 0.0909090909090909 0.0191082802547771
GO:BP GO:0048513 animal organ development 0.0286793522048574 3672 50 19 0.38 0.00517429193899782
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.0286793522048574 1037 129 16 0.124031007751938 0.0154291224686596
GO:BP GO:0050953 sensory perception of light stimulus 0.0286793522048574 218 24 3 0.125 0.0137614678899083
GO:BP GO:0048017 inositol lipid-mediated signaling 0.02880074714731 201 127 6 0.047244094488189 0.0298507462686567
GO:BP GO:0014909 smooth muscle cell migration 0.02880074714731 93 56 3 0.0535714285714286 0.032258064516129
GO:BP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 0.02880074714731 93 56 3 0.0535714285714286 0.032258064516129
GO:BP GO:0120036 plasma membrane bounded cell projection organization 0.0289550758115243 1569 144 23 0.159722222222222 0.0146590184831103
GO:BP GO:0045667 regulation of osteoblast differentiation 0.029177971178778 135 39 3 0.0769230769230769 0.0222222222222222
GO:BP GO:0003205 cardiac chamber development 0.0293296078550945 161 33 3 0.0909090909090909 0.0186335403726708
GO:BP GO:0070252 actin-mediated cell contraction 0.0293296078550945 123 43 3 0.0697674418604651 0.024390243902439
GO:BP GO:0003179 heart valve morphogenesis 0.029440287277185 54 98 3 0.0306122448979592 0.0555555555555556
GO:BP GO:0060538 skeletal muscle organ development 0.0301970329534567 170 32 3 0.09375 0.0176470588235294
GO:BP GO:0048522 positive regulation of cellular process 0.0301970329534567 5757 110 49 0.445454545454545 0.00851137745353483
GO:BP GO:0044057 regulation of system process 0.0301970329534567 623 140 12 0.0857142857142857 0.0192616372391653
GO:BP GO:0048639 positive regulation of developmental growth 0.0301970329534567 184 98 5 0.0510204081632653 0.0271739130434783
GO:BP GO:0099622 cardiac muscle cell membrane repolarization 0.0305640394474275 39 140 3 0.0214285714285714 0.0769230769230769
GO:BP GO:0098662 inorganic cation transmembrane transport 0.0306141482364903 794 140 14 0.1 0.017632241813602
GO:BP GO:0043542 endothelial cell migration 0.0306727885209278 290 39 4 0.102564102564103 0.0137931034482759
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.0309172865363281 325 138 8 0.0579710144927536 0.0246153846153846
GO:BP GO:0098660 inorganic ion transmembrane transport 0.0309172865363281 883 140 15 0.107142857142857 0.0169875424688562
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0311785442151423 790 46 7 0.152173913043478 0.00886075949367089
GO:BP GO:0060043 regulation of cardiac muscle cell proliferation 0.031514085069732 57 98 3 0.0306122448979592 0.0526315789473684
GO:BP GO:0070663 regulation of leukocyte proliferation 0.031514085069732 251 74 5 0.0675675675675676 0.0199203187250996
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.0321663545894058 155 74 4 0.0540540540540541 0.0258064516129032
GO:BP GO:0042391 regulation of membrane potential 0.0324690870883358 442 43 5 0.116279069767442 0.0113122171945701
GO:BP GO:0030048 actin filament-based movement 0.0324928086896156 152 76 4 0.0526315789473684 0.0263157894736842
GO:BP GO:0035904 aorta development 0.0324928086896156 58 98 3 0.0306122448979592 0.0517241379310345
GO:BP GO:0001890 placenta development 0.0326187243568621 147 39 3 0.0769230769230769 0.0204081632653061
GO:BP GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 0.0327955065264 87 134 4 0.0298507462686567 0.0459770114942529
GO:BP GO:0032870 cellular response to hormone stimulus 0.0327955065264 645 57 7 0.12280701754386 0.0108527131782946
GO:BP GO:0003002 regionalization 0.0327955065264 338 35 4 0.114285714285714 0.0118343195266272
GO:BP GO:0048608 reproductive structure development 0.0327955065264 429 14 3 0.214285714285714 0.00699300699300699
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.0327955065264 222 122 6 0.0491803278688525 0.027027027027027
GO:BP GO:0042221 response to chemical 0.0329969569578303 4781 12 8 0.666666666666667 0.00167329010667224
GO:BP GO:0035303 regulation of dephosphorylation 0.0329969569578303 217 27 3 0.111111111111111 0.0138248847926267
GO:BP GO:0043065 positive regulation of apoptotic process 0.0330111767434022 604 46 6 0.130434782608696 0.00993377483443709
GO:BP GO:0061458 reproductive system development 0.0330111767434022 432 14 3 0.214285714285714 0.00694444444444444
GO:BP GO:0043491 protein kinase B signaling 0.0330931624192133 286 127 7 0.0551181102362205 0.0244755244755245
GO:BP GO:0048518 positive regulation of biological process 0.0331448249521423 6363 143 66 0.461538461538462 0.0103724658180104
GO:BP GO:0010632 regulation of epithelial cell migration 0.0332837937206383 306 39 4 0.102564102564103 0.0130718954248366
GO:BP GO:0001508 action potential 0.0336029260872365 137 43 3 0.0697674418604651 0.0218978102189781
GO:BP GO:0034330 cell junction organization 0.0338658430892324 722 125 12 0.096 0.0166204986149584
GO:BP GO:0014812 muscle cell migration 0.0340657673960478 106 56 3 0.0535714285714286 0.0283018867924528
GO:BP GO:0060048 cardiac muscle contraction 0.0340981288486206 139 43 3 0.0697674418604651 0.0215827338129496
GO:BP GO:0016049 cell growth 0.0340981288486206 495 137 10 0.072992700729927 0.0202020202020202
GO:BP GO:0046460 neutral lipid biosynthetic process 0.0340981288486206 51 118 3 0.0254237288135593 0.0588235294117647
GO:BP GO:0035265 organ growth 0.0340981288486206 182 33 3 0.0909090909090909 0.0164835164835165
GO:BP GO:0046622 positive regulation of organ growth 0.0340981288486206 61 98 3 0.0306122448979592 0.0491803278688525
GO:BP GO:0046463 acylglycerol biosynthetic process 0.0340981288486206 51 118 3 0.0254237288135593 0.0588235294117647
GO:BP GO:0045664 regulation of neuron differentiation 0.0345622591425547 202 138 6 0.0434782608695652 0.0297029702970297
GO:BP GO:0050896 response to stimulus 0.0348471851427074 9407 134 85 0.634328358208955 0.00903582438609546
GO:BP GO:0048010 vascular endothelial growth factor receptor signaling pathway 0.0348677385611161 98 124 4 0.032258064516129 0.0408163265306122
GO:BP GO:0043068 positive regulation of programmed cell death 0.0349028352238676 621 46 6 0.130434782608696 0.00966183574879227
GO:BP GO:0043087 regulation of GTPase activity 0.0352846623446229 493 117 9 0.0769230769230769 0.0182555780933063
GO:BP GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 0.0355051357334805 50 123 3 0.024390243902439 0.06
GO:BP GO:0009991 response to extracellular stimulus 0.0356631346823261 512 134 10 0.0746268656716418 0.01953125
GO:BP GO:0003170 heart valve development 0.0358082205540056 63 98 3 0.0306122448979592 0.0476190476190476
GO:BP GO:0008038 neuron recognition 0.0366383877983435 47 133 3 0.0225563909774436 0.0638297872340425
GO:BP GO:0120035 regulation of plasma membrane bounded cell projection organization 0.0366742344807587 638 144 12 0.0833333333333333 0.0188087774294671
GO:BP GO:0050771 negative regulation of axonogenesis 0.0368289038506242 68 92 3 0.0326086956521739 0.0441176470588235
GO:BP GO:0032412 regulation of ion transmembrane transporter activity 0.0370316039129846 270 140 7 0.05 0.0259259259259259
GO:BP GO:0001558 regulation of cell growth 0.0374349418018696 426 137 9 0.0656934306569343 0.0211267605633803
GO:BP GO:0051050 positive regulation of transport 0.0377307693567914 923 140 15 0.107142857142857 0.0162513542795233
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0382029409160995 1042 68 10 0.147058823529412 0.00959692898272553
GO:BP GO:0019751 polyol metabolic process 0.0383495524159251 132 96 4 0.0416666666666667 0.0303030303030303
GO:BP GO:0050794 regulation of cellular process 0.0383495524159251 11473 138 102 0.739130434782609 0.00889043842063976
GO:BP GO:0046578 regulation of Ras protein signal transduction 0.0384360127385069 199 102 5 0.0490196078431373 0.0251256281407035
GO:BP GO:0061337 cardiac conduction 0.0385255694615824 150 43 3 0.0697674418604651 0.02
GO:BP GO:0060038 cardiac muscle cell proliferation 0.0388245480940546 66 98 3 0.0306122448979592 0.0454545454545455
GO:BP GO:0034329 cell junction assembly 0.0391980610594349 438 67 6 0.0895522388059701 0.0136986301369863
GO:BP GO:0051960 regulation of nervous system development 0.0394750270043342 443 110 8 0.0727272727272727 0.018058690744921
GO:BP GO:0032680 regulation of tumor necrosis factor production 0.0408630443521511 163 127 5 0.0393700787401575 0.0306748466257669
GO:BP GO:0060411 cardiac septum morphogenesis 0.041526151248353 68 98 3 0.0306122448979592 0.0441176470588235
GO:BP GO:0048583 regulation of response to stimulus 0.0417536451031538 4278 131 44 0.33587786259542 0.0102851799906498
GO:BP GO:0098659 inorganic cation import across plasma membrane 0.0422116716057568 97 136 4 0.0294117647058824 0.0412371134020619
GO:BP GO:0032640 tumor necrosis factor production 0.0422116716057568 165 127 5 0.0393700787401575 0.0303030303030303
GO:BP GO:0031344 regulation of cell projection organization 0.0422116716057568 656 144 12 0.0833333333333333 0.0182926829268293
GO:BP GO:0099587 inorganic ion import across plasma membrane 0.0422116716057568 97 136 4 0.0294117647058824 0.0412371134020619
GO:BP GO:0003208 cardiac ventricle morphogenesis 0.0423862920152875 69 98 3 0.0306122448979592 0.0434782608695652
GO:BP GO:0022898 regulation of transmembrane transporter activity 0.0425042266219071 281 140 7 0.05 0.0249110320284698
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.0431161915695159 360 138 8 0.0579710144927536 0.0222222222222222
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.0434228013204149 167 127 5 0.0393700787401575 0.029940119760479
GO:BP GO:0007160 cell-matrix adhesion 0.0437242354583696 235 128 6 0.046875 0.025531914893617
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0439367155180816 3210 131 35 0.267175572519084 0.0109034267912773
GO:BP GO:0009743 response to carbohydrate 0.045070489430849 243 125 6 0.048 0.0246913580246914
GO:BP GO:0043647 inositol phosphate metabolic process 0.0452093915995426 73 96 3 0.03125 0.0410958904109589
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.0456467054426002 170 127 5 0.0393700787401575 0.0294117647058824
GO:BP GO:0030335 positive regulation of cell migration 0.0457061950691164 567 128 10 0.078125 0.017636684303351
GO:BP GO:0030834 regulation of actin filament depolymerization 0.0457257328221679 57 124 3 0.0241935483870968 0.0526315789473684
GO:BP GO:0010647 positive regulation of cell communication 0.0458415870824233 1777 129 22 0.170542635658915 0.0123804164321891
GO:BP GO:0035296 regulation of tube diameter 0.0458664145264495 135 102 4 0.0392156862745098 0.0296296296296296
GO:BP GO:0097746 blood vessel diameter maintenance 0.0458664145264495 135 102 4 0.0392156862745098 0.0296296296296296
GO:BP GO:0010942 positive regulation of cell death 0.0463808463136634 684 46 6 0.130434782608696 0.0087719298245614
GO:BP GO:0023056 positive regulation of signaling 0.0463808463136634 1782 129 22 0.170542635658915 0.0123456790123457
GO:BP GO:0035150 regulation of tube size 0.0463808463136634 136 102 4 0.0392156862745098 0.0294117647058824
GO:BP GO:0009628 response to abiotic stimulus 0.0463808463136634 1261 12 4 0.333333333333333 0.00317208564631245
GO:BP GO:0034446 substrate adhesion-dependent cell spreading 0.0465748983254599 109 128 4 0.03125 0.036697247706422
GO:BP GO:0031960 response to corticosteroid 0.0473023114943718 165 134 5 0.0373134328358209 0.0303030303030303
GO:BP GO:0009952 anterior/posterior pattern specification 0.047421804147768 211 35 3 0.0857142857142857 0.014218009478673
GO:BP GO:0009725 response to hormone 0.0477573182649591 921 57 8 0.140350877192982 0.00868621064060804
GO:BP GO:0014032 neural crest cell development 0.0477865456528081 80 92 3 0.0326086956521739 0.0375
GO:BP GO:0010631 epithelial cell migration 0.0482806748065575 370 39 4 0.102564102564103 0.0108108108108108
GO:BP GO:0034220 ion transmembrane transport 0.0485348724115443 1397 31 7 0.225806451612903 0.00501073729420186
GO:BP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 0.0485348724115443 133 56 3 0.0535714285714286 0.0225563909774436
GO:BP GO:0051336 regulation of hydrolase activity 0.0489039739370512 1321 49 9 0.183673469387755 0.00681302043906132
GO:BP GO:0090132 epithelium migration 0.0490694850378329 373 39 4 0.102564102564103 0.0107238605898123
GO:BP GO:0032409 regulation of transporter activity 0.0496466127038681 297 140 7 0.05 0.0235690235690236
GO:BP GO:0048844 artery morphogenesis 0.0496790911643693 77 98 3 0.0306122448979592 0.038961038961039
GO:BP GO:0070482 response to oxygen levels 0.0496790911643693 408 19 3 0.157894736842105 0.00735294117647059
GO:BP GO:0070542 response to fatty acid 0.0498021952102125 69 110 3 0.0272727272727273 0.0434782608695652
GO:BP GO:0090109 regulation of cell-substrate junction assembly 0.0498021952102125 64 119 3 0.0252100840336134 0.046875
GO:BP GO:0051893 regulation of focal adhesion assembly 0.0498021952102125 64 119 3 0.0252100840336134 0.046875
GO:BP GO:0071396 cellular response to lipid 0.0498021952102125 578 110 9 0.0818181818181818 0.0155709342560554
GO:BP GO:0042327 positive regulation of phosphorylation 0.0498021952102125 927 107 12 0.11214953271028 0.0129449838187702
GO:BP GO:0061041 regulation of wound healing 0.0498021952102125 136 56 3 0.0535714285714286 0.0220588235294118
GO:BP GO:0002027 regulation of heart rate 0.0498230854344389 104 140 4 0.0285714285714286 0.0384615384615385
GO:BP GO:0055021 regulation of cardiac muscle tissue growth 0.0498584517024209 78 98 3 0.0306122448979592 0.0384615384615385
GO:BP GO:0090130 tissue migration 0.0498584517024209 379 39 4 0.102564102564103 0.0105540897097625
GO:BP GO:0098657 import into cell 0.0498584517024209 235 136 6 0.0441176470588235 0.025531914893617
GO:CC GO:0070161 anchoring junction 0.000545858382741838 836 141 20 0.141843971631206 0.0239234449760766
GO:CC GO:0071944 cell periphery 0.000545858382741838 6169 142 72 0.507042253521127 0.0116712595234236
GO:CC GO:0005887 integral component of plasma membrane 0.000545858382741838 1645 142 30 0.211267605633803 0.0182370820668693
GO:CC GO:0031226 intrinsic component of plasma membrane 0.000580140070141971 1726 142 30 0.211267605633803 0.0173812282734647
GO:CC GO:0030312 external encapsulating structure 0.000860807964530532 563 80 11 0.1375 0.019538188277087
GO:CC GO:0031012 extracellular matrix 0.000860807964530532 562 80 11 0.1375 0.0195729537366548
GO:CC GO:0005925 focal adhesion 0.000966780818765517 420 129 12 0.0930232558139535 0.0285714285714286
GO:CC GO:0030055 cell-substrate junction 0.00104084945389809 427 129 12 0.0930232558139535 0.0281030444964871
GO:CC GO:0045177 apical part of cell 0.00134260309465823 431 76 9 0.118421052631579 0.0208816705336427
GO:CC GO:0016324 apical plasma membrane 0.00134260309465823 361 72 8 0.111111111111111 0.0221606648199446
GO:CC GO:0098797 plasma membrane protein complex 0.00134260309465823 694 142 16 0.112676056338028 0.0230547550432277
GO:CC GO:0030054 cell junction 0.00134260309465823 2105 142 32 0.225352112676056 0.0152019002375297
GO:CC GO:0043235 receptor complex 0.00288330394044895 522 11 4 0.363636363636364 0.00766283524904215
GO:CC GO:0009986 cell surface 0.00288330394044895 899 63 11 0.174603174603175 0.0122358175750834
GO:CC GO:1902495 transmembrane transporter complex 0.00288330394044895 325 142 10 0.0704225352112676 0.0307692307692308
GO:CC GO:0098800 inner mitochondrial membrane protein complex 0.0037237306755083 146 16 3 0.1875 0.0205479452054795
GO:CC GO:1990351 transporter complex 0.00378322910632173 340 142 10 0.0704225352112676 0.0294117647058824
GO:CC GO:0034703 cation channel complex 0.00464324729687826 227 142 8 0.0563380281690141 0.0352422907488987
GO:CC GO:0005604 basement membrane 0.00561860868002624 97 122 5 0.040983606557377 0.0515463917525773
GO:CC GO:0005615 extracellular space 0.00561860868002624 3594 76 27 0.355263157894737 0.00751252086811352
GO:CC GO:0031224 intrinsic component of membrane 0.00561860868002624 5868 31 19 0.612903225806452 0.00323790047716428
GO:CC GO:0098796 membrane protein complex 0.00561860868002624 1322 16 6 0.375 0.00453857791225416
GO:CC GO:0034702 ion channel complex 0.00561860868002624 302 142 9 0.0633802816901408 0.0298013245033113
GO:CC GO:0016021 integral component of membrane 0.00643149263014095 5711 11 9 0.818181818181818 0.00157590614603397
GO:CC GO:0005886 plasma membrane 0.00672439263359605 5681 142 61 0.429577464788732 0.0107375462066538
GO:CC GO:0005576 extracellular region 0.00672439263359605 4567 81 33 0.407407407407407 0.00722574994525947
GO:CC GO:0070062 extracellular exosome 0.00745115298814453 2176 76 19 0.25 0.00873161764705882
GO:CC GO:0097517 contractile actin filament bundle 0.00923470811233784 68 123 4 0.032520325203252 0.0588235294117647
GO:CC GO:0001725 stress fiber 0.00923470811233784 68 123 4 0.032520325203252 0.0588235294117647
GO:CC GO:1903561 extracellular vesicle 0.0107886864951191 2261 76 19 0.25 0.00840336134453781
GO:CC GO:0043230 extracellular organelle 0.0107886864951191 2263 76 19 0.25 0.00839593460008838
GO:CC GO:0098798 mitochondrial protein-containing complex 0.0119685005499406 270 16 3 0.1875 0.0111111111111111
GO:CC GO:0032432 actin filament bundle 0.0123549750202662 76 123 4 0.032520325203252 0.0526315789473684
GO:CC GO:0034705 potassium channel complex 0.0123549750202662 100 43 3 0.0697674418604651 0.03
GO:CC GO:0042641 actomyosin 0.0126726294826718 77 123 4 0.032520325203252 0.051948051948052
GO:CC GO:0015629 actin cytoskeleton 0.0144393966799636 513 123 10 0.0813008130081301 0.0194931773879142
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0159441432821264 421 127 9 0.0708661417322835 0.0213776722090261
GO:CC GO:0043202 lysosomal lumen 0.0200801441297965 97 114 4 0.0350877192982456 0.0412371134020619
GO:CC GO:0005902 microvillus 0.0230518143282417 91 127 4 0.031496062992126 0.043956043956044
GO:CC GO:0005739 mitochondrion 0.034527442849899 1673 9 4 0.444444444444444 0.00239091452480574
GO:CC GO:0032991 protein-containing complex 0.0374089676837073 5548 16 10 0.625 0.00180245133381399
GO:CC GO:0005743 mitochondrial inner membrane 0.0487606505156288 503 16 3 0.1875 0.00596421471172962
GO:MF GO:0030695 GTPase regulator activity 0.00553515333146194 487 121 12 0.0991735537190083 0.0246406570841889
GO:MF GO:0019838 growth factor binding 0.00553515333146194 138 60 5 0.0833333333333333 0.036231884057971
GO:MF GO:0060589 nucleoside-triphosphatase regulator activity 0.00805605698497268 530 136 13 0.0955882352941176 0.0245283018867925
GO:MF GO:0005539 glycosaminoglycan binding 0.0134716202314944 238 73 6 0.0821917808219178 0.0252100840336134
GO:MF GO:0016849 phosphorus-oxygen lyase activity 0.0134716202314944 22 109 3 0.0275229357798165 0.136363636363636
GO:MF GO:0050839 cell adhesion molecule binding 0.0135273534889676 546 133 12 0.0902255639097744 0.021978021978022
GO:MF GO:0099106 ion channel regulator activity 0.0135273534889676 120 97 5 0.0515463917525773 0.0416666666666667
GO:MF GO:0098772 molecular function regulator 0.0135273534889676 2363 121 29 0.239669421487603 0.0122725349132459
GO:MF GO:0043548 phosphatidylinositol 3-kinase binding 0.0155296577857664 32 101 3 0.0297029702970297 0.09375
GO:MF GO:0016247 channel regulator activity 0.0175291691065247 149 140 6 0.0428571428571429 0.0402684563758389
GO:MF GO:0005249 voltage-gated potassium channel activity 0.0192823005383897 89 43 3 0.0697674418604651 0.0337078651685393
GO:MF GO:0004713 protein tyrosine kinase activity 0.0290117890197086 144 119 5 0.0420168067226891 0.0347222222222222
GO:MF GO:0022890 inorganic cation transmembrane transporter activity 0.0290117890197086 591 9 3 0.333333333333333 0.0050761421319797
GO:MF GO:0030234 enzyme regulator activity 0.0298707527558315 1248 121 17 0.140495867768595 0.0136217948717949
GO:MF GO:0005085 guanyl-nucleotide exchange factor activity 0.0298707527558315 217 121 6 0.0495867768595041 0.0276497695852535
GO:MF GO:0008324 cation transmembrane transporter activity 0.0298707527558315 639 9 3 0.333333333333333 0.00469483568075117
GO:MF GO:0005267 potassium channel activity 0.0298707527558315 125 43 3 0.0697674418604651 0.024
GO:MF GO:0005518 collagen binding 0.0298707527558315 70 73 3 0.0410958904109589 0.0428571428571429
GO:MF GO:0046983 protein dimerization activity 0.0298707527558315 1069 72 11 0.152777777777778 0.010289990645463
GO:MF GO:0015459 potassium channel regulator activity 0.0298707527558315 54 97 3 0.0309278350515464 0.0555555555555556
GO:MF GO:0005178 integrin binding 0.0317513094256016 147 128 5 0.0390625 0.0340136054421769
GO:MF GO:0015318 inorganic molecular entity transmembrane transporter activity 0.031859748141693 831 15 4 0.266666666666667 0.00481347773766546
GO:MF GO:1901681 sulfur compound binding 0.0320140681538926 264 73 5 0.0684931506849315 0.0189393939393939
GO:MF GO:0005244 voltage-gated ion channel activity 0.0322364376000024 200 97 5 0.0515463917525773 0.025
GO:MF GO:0022832 voltage-gated channel activity 0.0323672286478406 201 97 5 0.0515463917525773 0.0248756218905473
GO:MF GO:0008201 heparin binding 0.0339701081164856 168 73 4 0.0547945205479452 0.0238095238095238
GO:MF GO:0022843 voltage-gated cation channel activity 0.0341207237829154 143 43 3 0.0697674418604651 0.020979020979021
GO:MF GO:0097367 carbohydrate derivative binding 0.0349261857241865 2285 119 25 0.210084033613445 0.0109409190371991
GO:MF GO:0005102 signaling receptor binding 0.0379005849039968 1672 81 15 0.185185185185185 0.00897129186602871
GO:MF GO:0004714 transmembrane receptor protein tyrosine kinase activity 0.0379761338322986 63 107 3 0.0280373831775701 0.0476190476190476
GO:MF GO:0015079 potassium ion transmembrane transporter activity 0.0379761338322986 161 43 3 0.0697674418604651 0.0186335403726708
GO:MF GO:0015075 ion transmembrane transporter activity 0.0379761338322986 956 15 4 0.266666666666667 0.00418410041841004
GO:MF GO:0005096 GTPase activator activity 0.0438885242786918 278 117 6 0.0512820512820513 0.0215827338129496
GO:MF GO:0098631 cell adhesion mediator activity 0.0438885242786918 58 133 3 0.0225563909774436 0.0517241379310345
GO:MF GO:0004860 protein kinase inhibitor activity 0.0438885242786918 70 106 3 0.0283018867924528 0.0428571428571429
GO:MF GO:0019210 kinase inhibitor activity 0.0448941380619676 74 106 3 0.0283018867924528 0.0405405405405405
GO:MF GO:0022857 transmembrane transporter activity 0.0456434766050845 1075 15 4 0.266666666666667 0.00372093023255814
GO:MF GO:0015267 channel activity 0.0475874665362145 484 140 9 0.0642857142857143 0.0185950413223141
GO:MF GO:0019001 guanyl nucleotide binding 0.0475874665362145 403 137 8 0.0583941605839416 0.0198511166253102
GO:MF GO:0032561 guanyl ribonucleotide binding 0.0475874665362145 403 137 8 0.0583941605839416 0.0198511166253102
GO:MF GO:0060090 molecular adaptor activity 0.0475874665362145 329 48 4 0.0833333333333333 0.0121580547112462
GO:MF GO:0022803 passive transmembrane transporter activity 0.0475874665362145 485 140 9 0.0642857142857143 0.0185567010309278
GO:MF GO:0001217 DNA-binding transcription repressor activity 0.0475874665362145 314 110 6 0.0545454545454545 0.0191082802547771
GO:MF GO:0008134 transcription factor binding 0.0475874665362145 676 137 11 0.0802919708029197 0.0162721893491124
GO:MF GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 0.0475874665362145 312 110 6 0.0545454545454545 0.0192307692307692
GO:MF GO:0003924 GTPase activity 0.0475874665362145 328 137 7 0.0510948905109489 0.0213414634146341
GO:MF GO:0035591 signaling adaptor activity 0.0476602576592844 70 124 3 0.0241935483870968 0.0428571428571429
GO:MF GO:0045296 cadherin binding 0.0476761223219102 333 76 5 0.0657894736842105 0.015015015015015
GO:MF GO:0019199 transmembrane receptor protein kinase activity 0.04787955543835 82 107 3 0.0280373831775701 0.0365853658536585
GO:MF GO:0008081 phosphoric diester hydrolase activity 0.0479374699825917 92 96 3 0.03125 0.0326086956521739
GO:MF GO:0005215 transporter activity 0.0489657764103844 1185 15 4 0.266666666666667 0.00337552742616034
GO:MF GO:0030674 protein-macromolecule adaptor activity 0.0496088682007715 266 136 6 0.0441176470588235 0.0225563909774436
TF TF:M10108 Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG 7.23681750274148e-06 6511 142 82 0.577464788732394 0.0125940715711872
TF TF:M00706 Factor: TFII-I; motif: RGAGGKAGG 0.00444704247226288 5714 23 18 0.782608695652174 0.00315015750787539
TF TF:M07436 Factor: WT1; motif: NNGGGNGGGSGN 0.00759108689256642 6182 142 70 0.492957746478873 0.0113231963765772
TF TF:M00649 Factor: MAZ; motif: GGGGAGGG 0.00759108689256642 9327 126 85 0.674603174603175 0.0091133269003967
TF TF:M04595_1 Factor: SALL2; motif: GGGTGGG; match class: 1 0.00759108689256642 7373 142 79 0.556338028169014 0.0107147701071477
TF TF:M07289_1 Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 0.00759108689256642 10555 136 98 0.720588235294118 0.00928469919469446
TF TF:M07208 Factor: EGR1; motif: NCNCCGCCCCCGCN 0.00809915347263062 6183 144 70 0.486111111111111 0.0113213650331554
TF TF:M09784 Factor: RELB; motif: NNATTCCCCNN 0.00809915347263062 5356 135 60 0.444444444444444 0.0112023898431665
TF TF:M07368_1 Factor: Smad4; motif: NCAGACAN; match class: 1 0.0105956636164823 503 3 3 1 0.00596421471172962
TF TF:M09883 Factor: C/EBPgamma; motif: RTTGCATCAKNN 0.0120718270497728 84 13 3 0.230769230769231 0.0357142857142857
TF TF:M07397 Factor: ZBP89; motif: CCCCKCCCCCNN 0.0125073551624775 7143 71 43 0.605633802816901 0.00601987960240795
TF TF:M01118 Factor: WT1; motif: SMCNCCNSC 0.0125073551624775 6808 114 61 0.535087719298246 0.00896004700352526
TF TF:M09984 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG 0.0127767715867687 9544 142 93 0.654929577464789 0.00974434199497066
TF TF:M01973 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC 0.0132461783450638 6167 105 53 0.504761904761905 0.00859413004702449
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0140024937810709 16384 94 91 0.968085106382979 0.00555419921875
TF TF:M08905_1 Factor: TIEG1; motif: GGSGGKGNNN; match class: 1 0.0156654558707224 1017 142 20 0.140845070422535 0.0196656833824975
TF TF:M00156 Factor: RORalpha1; motif: NWAWNNAGGTCAN 0.0176860778377331 255 130 9 0.0692307692307692 0.0352941176470588
TF TF:M01104 Factor: MOVO-B; motif: GNGGGGG 0.0181616093295195 10261 142 97 0.683098591549296 0.00945326966182633
TF TF:M10158 Factor: ZNF563; motif: NGNNTCMTNNCNGGCAGCTGY 0.0181616093295195 6067 71 38 0.535211267605634 0.00626339212131202
TF TF:M09724 Factor: DATF1; motif: SNGGRRGCWGNGGG 0.0238149403023969 8400 110 67 0.609090909090909 0.00797619047619048
TF TF:M10108_1 Factor: WT1; motif: RGGNGGGGGAGGRGGNGGRG; match class: 1 0.0238149403023969 2864 131 36 0.274809160305344 0.0125698324022346
TF TF:M01889_1 Factor: Smad4; motif: TGTCTGN; match class: 1 0.0238149403023969 869 3 3 1 0.00345224395857307
TF TF:M10172 Factor: HKR2; motif: NGNCNGAGGGMGGAGG 0.026470309352993 1391 112 20 0.178571428571429 0.0143781452192667
TF TF:M07289 Factor: GKLF; motif: NNNRGGNGNGGSN 0.026470309352993 14646 142 124 0.873239436619718 0.0084664754881879
TF TF:M10112_1 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 0.0275142807753238 4075 114 41 0.359649122807018 0.0100613496932515
TF TF:M10026 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN 0.0297168800085851 8389 133 78 0.586466165413534 0.00929789009417094
TF TF:M11097 Factor: Max; motif: MCATGTGNNNNMCATGTGN 0.0297168800085851 618 123 13 0.105691056910569 0.0210355987055016
TF TF:M03814 Factor: BTEB2; motif: GNAGGGGGNGGGSSNN 0.0330456484974399 5124 142 57 0.401408450704225 0.0111241217798595
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0330456484974399 5262 115 49 0.426086956521739 0.00931204865070315
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.0354465664460734 6334 136 64 0.470588235294118 0.0101041995579413
TF TF:M00947 Factor: CP2/LBP-1c/LSF; motif: GCTGGNTNGNNCYNG 0.0354465664460734 8413 134 78 0.582089552238806 0.00927136574349221
TF TF:M10158_1 Factor: ZNF563; motif: NGNNTCMTNNCNGGCAGCTGY; match class: 1 0.0354465664460734 1310 71 14 0.197183098591549 0.0106870229007634
TF TF:M07226_1 Factor: SP1; motif: NCCCCKCCCCC; match class: 1 0.0354465664460734 3915 136 45 0.330882352941176 0.0114942528735632
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.0354465664460734 11467 137 100 0.72992700729927 0.00872067672451382
TF TF:M01100_1 Factor: LRF; motif: GGGGKYNNB; match class: 1 0.0354465664460734 2762 136 35 0.257352941176471 0.0126719768283852
TF TF:M04863_1 Factor: TF3C-beta; motif: CCNGGAGGGCTTCCTGGAGGAG; match class: 1 0.0354465664460734 8573 118 71 0.601694915254237 0.00828181500058323
TF TF:M09834 Factor: ZNF148; motif: NNNNNNCCNNCCCCTCCCCCACCCN 0.0354465664460734 6953 142 71 0.5 0.0102114195311376
TF TF:M10017 Factor: LRH-1; motif: NNYCAAGGYCA 0.0356240161872273 2629 80 23 0.2875 0.00874857360213009
TF TF:M01692_1 Factor: LTF; motif: GKVACTTNC; match class: 1 0.0356240161872273 507 137 12 0.0875912408759124 0.0236686390532544
TF TF:M09659 Factor: PU.1; motif: NRAAAGAGGAAGTGARA 0.0391235832984326 2523 4 4 1 0.001585414189457
TF TF:M12057_1 Factor: ZBP99; motif: GCCCMTCCCCCR; match class: 1 0.0391235832984326 1359 132 21 0.159090909090909 0.0154525386313466
TF TF:M02023 Factor: MAZ; motif: NKGGGAGGGGRGGR 0.0391235832984326 7134 142 72 0.507042253521127 0.0100925147182506
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 0.0391235832984326 7557 137 73 0.532846715328467 0.00965991795686119
TF TF:M01219 Factor: SP1:SP3; motif: CCSCCCCCYCC 0.0404714028234709 6812 117 59 0.504273504273504 0.00866118614210217
TF TF:M07040 Factor: GKLF; motif: NNRRGRRNGNSNNN 0.0405466744881488 12705 124 98 0.790322580645161 0.00771349862258953
TF TF:M00244_1 Factor: NGFI-C; motif: WTGCGTGGGYGG; match class: 1 0.0412740958847499 1772 133 25 0.18796992481203 0.0141083521444695
TF TF:M00033_1 Factor: p300; motif: NNNGGGAGTNNNNS; match class: 1 0.0415560916933854 2588 142 34 0.23943661971831 0.0131375579598145
TF TF:M07354_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0437770598333882 3561 135 41 0.303703703703704 0.0115136197697276
TF TF:M07429_1 Factor: SMAD3; motif: CAGACAS; match class: 1 0.0440236209954057 1381 3 3 1 0.00217233888486604
TF TF:M12354 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN 0.0469953131132974 10961 115 82 0.71304347826087 0.0074810692455068
TF TF:M00649_1 Factor: MAZ; motif: GGGGAGGG; match class: 1 0.0475448058678624 4166 114 40 0.350877192982456 0.00960153624579933
TF TF:M09894_1 Factor: E2F-4; motif: SNGGGCGGGAANN; match class: 1 0.0475448058678624 13929 138 115 0.833333333333333 0.00825615622083423
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.0475448058678624 8031 144 79 0.548611111111111 0.00983688208193251
TF TF:M09609 Factor: ER-alpha; motif: NNAGGTCANNNTGNCCN 0.0475448058678624 2059 144 29 0.201388888888889 0.0140845070422535
TF TF:M07368 Factor: Smad4; motif: NCAGACAN 0.0487761744192123 3856 20 11 0.55 0.00285269709543568
TF TF:M05318 Factor: KLF8; motif: NGGGCGGGGG 0.0487761744192123 829 105 13 0.123809523809524 0.0156815440289505
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.0487761744192123 14473 138 118 0.855072463768116 0.00815311269260001
TF TF:M05319 Factor: KLF7; motif: NGGGCGGGGG 0.0487761744192123 829 105 13 0.123809523809524 0.0156815440289505
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0487761744192123 13611 142 116 0.816901408450704 0.00852251855117185

pS15 transcription factor target enrichment of top program genes

TF enrichment of pS15
TFs corrosponding to activation of pS15. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.