pEpi37 program activity among Epithelial cells

Activation of pEpi37
pEpi37 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi37 by different cell subtypes
pEpi37 gene program activation among cells of different subtypes (Epithelial cells).

pEpi37 top program genes

Top genes of pEpi37 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi37 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi37
pEpi37 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:6442 Cytochrome c oxidase, mitochondrial 0.00223095787243217 14 15 3 0.2 0.214285714285714
GO:BP GO:0006397 mRNA processing 1.00792139024585e-12 532 117 26 0.222222222222222 0.0488721804511278
GO:BP GO:0008380 RNA splicing 1.52819286997591e-12 456 117 24 0.205128205128205 0.0526315789473684
GO:BP GO:0006396 RNA processing 4.38900672326275e-11 964 118 31 0.26271186440678 0.0321576763485477
GO:BP GO:0000375 RNA splicing, via transesterification reactions 5.77127443896091e-11 364 116 20 0.172413793103448 0.0549450549450549
GO:BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 5.77127443896091e-11 361 116 20 0.172413793103448 0.0554016620498615
GO:BP GO:0000398 mRNA splicing, via spliceosome 5.77127443896091e-11 361 116 20 0.172413793103448 0.0554016620498615
GO:BP GO:0006119 oxidative phosphorylation 2.34739096451675e-10 151 18 8 0.444444444444444 0.0529801324503311
GO:BP GO:0016071 mRNA metabolic process 2.8893123977967e-10 874 117 28 0.239316239316239 0.0320366132723112
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 2.8893123977967e-10 99 16 7 0.4375 0.0707070707070707
GO:BP GO:0042773 ATP synthesis coupled electron transport 2.8893123977967e-10 100 16 7 0.4375 0.07
GO:BP GO:0022904 respiratory electron transport chain 8.07769107239372e-10 117 16 7 0.4375 0.0598290598290598
GO:BP GO:0022900 electron transport chain 1.56776242461441e-08 180 16 7 0.4375 0.0388888888888889
GO:BP GO:0090304 nucleic acid metabolic process 2.11589076770564e-08 5226 122 69 0.565573770491803 0.013203214695752
GO:BP GO:0045333 cellular respiration 2.11589076770564e-08 192 16 7 0.4375 0.0364583333333333
GO:BP GO:0046034 ATP metabolic process 3.89920107944139e-08 314 18 8 0.444444444444444 0.0254777070063694
GO:BP GO:0006139 nucleobase-containing compound metabolic process 1.74876107043042e-07 5746 122 71 0.581967213114754 0.0123564218586843
GO:BP GO:0015990 electron transport coupled proton transport 1.92842299079798e-07 5 11 3 0.272727272727273 0.6
GO:BP GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient 1.92842299079798e-07 5 11 3 0.272727272727273 0.6
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 2.57936616599759e-07 289 16 7 0.4375 0.0242214532871972
GO:BP GO:0016070 RNA metabolic process 2.57936616599759e-07 4710 121 62 0.512396694214876 0.0131634819532909
GO:BP GO:0046483 heterocycle metabolic process 4.88878691570095e-07 5904 122 71 0.581967213114754 0.0120257452574526
GO:BP GO:1902600 proton transmembrane transport 6.21527662809604e-07 157 18 6 0.333333333333333 0.0382165605095541
GO:BP GO:0006725 cellular aromatic compound metabolic process 6.47647227647801e-07 5956 122 71 0.581967213114754 0.0119207521826729
GO:BP GO:0009060 aerobic respiration 6.47647227647801e-07 89 15 5 0.333333333333333 0.0561797752808989
GO:BP GO:0006091 generation of precursor metabolites and energy 1.61300013035084e-06 538 18 8 0.444444444444444 0.0148698884758364
GO:BP GO:0034641 cellular nitrogen compound metabolic process 2.63729320587588e-06 6563 122 74 0.60655737704918 0.0112753314033217
GO:BP GO:1901360 organic cyclic compound metabolic process 3.73746145564002e-06 6201 122 71 0.581967213114754 0.0114497661667473
GO:BP GO:0006123 mitochondrial electron transport, cytochrome c to oxygen 3.73359636466202e-05 20 15 3 0.2 0.15
GO:BP GO:0019646 aerobic electron transport chain 3.73359636466202e-05 20 15 3 0.2 0.15
GO:BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 0.00105862772047981 56 16 3 0.1875 0.0535714285714286
GO:BP GO:0018023 peptidyl-lysine trimethylation 0.00153650284894558 47 132 5 0.0378787878787879 0.106382978723404
GO:BP GO:0032981 mitochondrial respiratory chain complex I assembly 0.00158738162690618 67 16 3 0.1875 0.0447761194029851
GO:BP GO:0010257 NADH dehydrogenase complex assembly 0.00158738162690618 67 16 3 0.1875 0.0447761194029851
GO:BP GO:0043484 regulation of RNA splicing 0.00158738162690618 160 98 7 0.0714285714285714 0.04375
GO:BP GO:0055114 obsolete oxidation-reduction process 0.00158738162690618 745 16 6 0.375 0.00805369127516779
GO:BP GO:0051168 nuclear export 0.00159521312883741 204 139 9 0.0647482014388489 0.0441176470588235
GO:BP GO:0010467 gene expression 0.00159521312883741 6179 111 59 0.531531531531532 0.00954847062631494
GO:BP GO:0050684 regulation of mRNA processing 0.00291744750659679 158 111 7 0.0630630630630631 0.0443037974683544
GO:BP GO:0006406 mRNA export from nucleus 0.00291744750659679 112 108 6 0.0555555555555556 0.0535714285714286
GO:BP GO:0071427 mRNA-containing ribonucleoprotein complex export from nucleus 0.00291744750659679 112 108 6 0.0555555555555556 0.0535714285714286
GO:BP GO:0006325 chromatin organization 0.00306575353481737 824 139 18 0.129496402877698 0.0218446601941748
GO:BP GO:0098662 inorganic cation transmembrane transport 0.0040744414332358 794 18 6 0.333333333333333 0.00755667506297229
GO:BP GO:0033108 mitochondrial respiratory chain complex assembly 0.00459424271691401 103 16 3 0.1875 0.029126213592233
GO:BP GO:0006405 RNA export from nucleus 0.00559724789769908 143 139 7 0.0503597122302158 0.048951048951049
GO:BP GO:0031060 regulation of histone methylation 0.00580271128025516 67 132 5 0.0378787878787879 0.0746268656716418
GO:BP GO:0071426 ribonucleoprotein complex export from nucleus 0.00580271128025516 130 108 6 0.0555555555555556 0.0461538461538462
GO:BP GO:0071166 ribonucleoprotein complex localization 0.00592011003563735 131 108 6 0.0555555555555556 0.0458015267175573
GO:BP GO:0098660 inorganic ion transmembrane transport 0.006413898140401 883 18 6 0.333333333333333 0.00679501698754247
GO:BP GO:0051028 mRNA transport 0.00641406407646381 152 136 7 0.0514705882352941 0.0460526315789474
GO:BP GO:0050657 nucleic acid transport 0.00664960131839262 201 139 8 0.0575539568345324 0.0398009950248756
GO:BP GO:0050658 RNA transport 0.00664960131839262 201 139 8 0.0575539568345324 0.0398009950248756
GO:BP GO:0051236 establishment of RNA localization 0.00708171868751804 204 139 8 0.0575539568345324 0.0392156862745098
GO:BP GO:0098655 cation transmembrane transport 0.00708171868751804 914 18 6 0.333333333333333 0.00656455142231947
GO:BP GO:0031062 positive regulation of histone methylation 0.00761536891321567 40 132 4 0.0303030303030303 0.1
GO:BP GO:2001252 positive regulation of chromosome organization 0.00849390261780414 168 132 7 0.053030303030303 0.0416666666666667
GO:BP GO:0097711 ciliary basal body-plasma membrane docking 0.0119942437803198 95 114 5 0.043859649122807 0.0526315789473684
GO:BP GO:0006913 nucleocytoplasmic transport 0.0142340020437375 354 139 10 0.0719424460431655 0.0282485875706215
GO:BP GO:0000245 spliceosomal complex assembly 0.0144442155447999 59 108 4 0.037037037037037 0.0677966101694915
GO:BP GO:0051169 nuclear transport 0.0147159652016964 357 139 10 0.0719424460431655 0.0280112044817927
GO:BP GO:0048024 regulation of mRNA splicing, via spliceosome 0.0155295004900196 119 98 5 0.0510204081632653 0.0420168067226891
GO:BP GO:0006611 protein export from nucleus 0.0162450845946915 185 136 7 0.0514705882352941 0.0378378378378378
GO:BP GO:0006403 RNA localization 0.0162707681618104 238 139 8 0.0575539568345324 0.0336134453781513
GO:BP GO:0016571 histone methylation 0.0163359525994906 138 132 6 0.0454545454545455 0.0434782608695652
GO:BP GO:0007346 regulation of mitotic cell cycle 0.0163359525994906 619 114 12 0.105263157894737 0.0193861066235864
GO:BP GO:0016310 phosphorylation 0.0166725323077653 2138 18 8 0.444444444444444 0.00374181478016838
GO:BP GO:0051276 chromosome organization 0.0181958506817142 1258 139 21 0.151079136690647 0.0166931637519873
GO:BP GO:0006376 mRNA splice site selection 0.0208890357585428 33 96 3 0.03125 0.0909090909090909
GO:BP GO:0006812 cation transport 0.0221502253862828 1197 18 6 0.333333333333333 0.0050125313283208
GO:BP GO:0000381 regulation of alternative mRNA splicing, via spliceosome 0.0241531968608869 78 98 4 0.0408163265306122 0.0512820512820513
GO:BP GO:0015931 nucleobase-containing compound transport 0.0254508554281068 260 139 8 0.0575539568345324 0.0307692307692308
GO:BP GO:0044237 cellular metabolic process 0.0270574317184137 10871 122 90 0.737704918032787 0.00827890718425168
GO:BP GO:1905269 positive regulation of chromatin organization 0.0271891230106903 105 132 5 0.0378787878787879 0.0476190476190476
GO:BP GO:0030902 hindbrain development 0.0271891230106903 152 24 3 0.125 0.0197368421052632
GO:BP GO:0031124 mRNA 3'-end processing 0.0321322258035956 106 137 5 0.0364963503649635 0.0471698113207547
GO:BP GO:0006338 chromatin remodeling 0.0327780424224226 215 139 7 0.0503597122302158 0.0325581395348837
GO:BP GO:0000380 alternative mRNA splicing, via spliceosome 0.0327780424224226 89 98 4 0.0408163265306122 0.0449438202247191
GO:BP GO:0034968 histone lysine methylation 0.0333893849419164 113 132 5 0.0378787878787879 0.0442477876106195
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.0337552217115052 4199 111 40 0.36036036036036 0.00952607763753275
GO:BP GO:0070925 organelle assembly 0.0337552217115052 895 114 14 0.12280701754386 0.0156424581005587
GO:BP GO:1903311 regulation of mRNA metabolic process 0.0351443543561508 356 111 8 0.0720720720720721 0.0224719101123595
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 0.0369798473096471 4091 111 39 0.351351351351351 0.0095331214861892
GO:BP GO:0034220 ion transmembrane transport 0.0369798473096471 1397 18 6 0.333333333333333 0.00429491768074445
GO:BP GO:1900542 regulation of purine nucleotide metabolic process 0.0369798473096471 119 132 5 0.0378787878787879 0.0420168067226891
GO:BP GO:0031503 protein-containing complex localization 0.0369798473096471 289 108 7 0.0648148148148148 0.0242214532871972
GO:BP GO:1903578 regulation of ATP metabolic process 0.0369798473096471 119 132 5 0.0378787878787879 0.0420168067226891
GO:BP GO:0048562 embryonic organ morphogenesis 0.0369798473096471 292 54 5 0.0925925925925926 0.0171232876712329
GO:BP GO:0006974 cellular response to DNA damage stimulus 0.0369798473096471 888 130 15 0.115384615384615 0.0168918918918919
GO:BP GO:0051252 regulation of RNA metabolic process 0.0370692198854255 3822 111 37 0.333333333333333 0.00968079539508111
GO:BP GO:0043414 macromolecule methylation 0.0372258681145653 312 132 8 0.0606060606060606 0.0256410256410256
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0372258681145653 1107 16 5 0.3125 0.004516711833785
GO:BP GO:0006140 regulation of nucleotide metabolic process 0.0372258681145653 121 132 5 0.0378787878787879 0.0413223140495868
GO:BP GO:0006351 transcription, DNA-templated 0.0372258681145653 3714 111 36 0.324324324324324 0.00969305331179321
GO:BP GO:0006479 protein methylation 0.0372258681145653 178 132 6 0.0454545454545455 0.0337078651685393
GO:BP GO:0007005 mitochondrion organization 0.0372258681145653 561 18 4 0.222222222222222 0.0071301247771836
GO:BP GO:0019438 aromatic compound biosynthetic process 0.0372258681145653 4278 111 40 0.36036036036036 0.00935016362786349
GO:BP GO:0008213 protein alkylation 0.0372258681145653 178 132 6 0.0454545454545455 0.0337078651685393
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0372258681145653 5017 111 45 0.405405405405405 0.00896950368746263
GO:BP GO:0018205 peptidyl-lysine modification 0.0372258681145653 405 80 7 0.0875 0.0172839506172839
GO:BP GO:0018130 heterocycle biosynthetic process 0.0372258681145653 4269 111 40 0.36036036036036 0.009369875849145
GO:BP GO:0032774 RNA biosynthetic process 0.0372258681145653 3731 111 36 0.324324324324324 0.00964888769766819
GO:BP GO:0097659 nucleic acid-templated transcription 0.0372258681145653 3715 111 36 0.324324324324324 0.00969044414535666
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 0.0372258681145653 451 114 9 0.0789473684210526 0.0199556541019956
GO:BP GO:1902275 regulation of chromatin organization 0.0372258681145653 196 51 4 0.0784313725490196 0.0204081632653061
GO:BP GO:0018022 peptidyl-lysine methylation 0.0398099708974027 130 132 5 0.0378787878787879 0.0384615384615385
GO:BP GO:0006110 regulation of glycolytic process 0.0398099708974027 79 132 4 0.0303030303030303 0.0506329113924051
GO:BP GO:0045787 positive regulation of cell cycle 0.042381479781717 403 108 8 0.0740740740740741 0.0198511166253102
GO:BP GO:0006281 DNA repair 0.0432677194425323 576 130 11 0.0846153846153846 0.0190972222222222
GO:BP GO:2000112 regulation of cellular macromolecule biosynthetic process 0.0442171357612689 4071 111 38 0.342342342342342 0.00933431589290101
GO:BP GO:0046939 nucleotide phosphorylation 0.0448992248911263 135 132 5 0.0378787878787879 0.037037037037037
GO:BP GO:2000781 positive regulation of double-strand break repair 0.0453688651137333 41 130 3 0.0230769230769231 0.0731707317073171
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 0.0480506430190224 4102 111 38 0.342342342342342 0.00926377376889322
GO:CC GO:0098803 respiratory chain complex 1.20280750177553e-10 86 16 7 0.4375 0.0813953488372093
GO:CC GO:0070469 respirasome 2.2019893744156e-10 103 16 7 0.4375 0.0679611650485437
GO:CC GO:0016607 nuclear speck 2.2071836161602e-09 412 108 18 0.166666666666667 0.0436893203883495
GO:CC GO:0005681 spliceosomal complex 1.43302215771993e-08 191 116 13 0.112068965517241 0.0680628272251309
GO:CC GO:0098800 inner mitochondrial membrane protein complex 2.05090762928907e-07 146 18 6 0.333333333333333 0.0410958904109589
GO:CC GO:0140513 nuclear protein-containing complex 2.05090762928907e-07 1249 136 30 0.220588235294118 0.0240192153722978
GO:CC GO:0016604 nuclear body 3.6934149195381e-07 816 111 21 0.189189189189189 0.0257352941176471
GO:CC GO:0005746 mitochondrial respirasome 3.6934149195381e-07 89 16 5 0.3125 0.0561797752808989
GO:CC GO:0005743 mitochondrial inner membrane 3.6934149195381e-07 503 18 8 0.444444444444444 0.0159045725646123
GO:CC GO:0070069 cytochrome complex 4.09396401830705e-07 34 15 4 0.266666666666667 0.117647058823529
GO:CC GO:0019866 organelle inner membrane 6.30008359922633e-07 564 18 8 0.444444444444444 0.0141843971631206
GO:CC GO:1990204 oxidoreductase complex 8.38736987849259e-07 113 16 5 0.3125 0.0442477876106195
GO:CC GO:0005634 nucleus 1.31170480050735e-06 7592 123 79 0.642276422764228 0.0104056902002107
GO:CC GO:0098798 mitochondrial protein-containing complex 3.19889652279894e-06 270 18 6 0.333333333333333 0.0222222222222222
GO:CC GO:0031966 mitochondrial membrane 4.01354174630489e-06 746 18 8 0.444444444444444 0.0107238605898123
GO:CC GO:0005740 mitochondrial envelope 6.24562904037011e-06 797 18 8 0.444444444444444 0.0100376411543287
GO:CC GO:0045277 respiratory chain complex IV 1.09693589902894e-05 21 15 3 0.2 0.142857142857143
GO:CC GO:0098796 membrane protein complex 2.0315955217255e-05 1322 18 9 0.5 0.00680786686838124
GO:CC GO:0043231 intracellular membrane-bounded organelle 2.34020311748758e-05 11296 100 82 0.82 0.00725920679886686
GO:CC GO:0031981 nuclear lumen 3.61050754794591e-05 4444 122 52 0.426229508196721 0.0117011701170117
GO:CC GO:0043229 intracellular organelle 7.59329994924767e-05 12491 100 86 0.86 0.0068849571691618
GO:CC GO:0005654 nucleoplasm 0.000104726618990564 4102 132 51 0.386363636363636 0.0124329595319356
GO:CC GO:0031967 organelle envelope 0.000109893584807372 1237 18 8 0.444444444444444 0.00646725949878739
GO:CC GO:0031975 envelope 0.000109893584807372 1237 18 8 0.444444444444444 0.00646725949878739
GO:CC GO:0005739 mitochondrion 0.000109893584807372 1673 18 9 0.5 0.00537955768081291
GO:CC GO:0030964 NADH dehydrogenase complex 0.000126289819136936 51 16 3 0.1875 0.0588235294117647
GO:CC GO:0005747 mitochondrial respiratory chain complex I 0.000126289819136936 51 16 3 0.1875 0.0588235294117647
GO:CC GO:0045271 respiratory chain complex I 0.000126289819136936 51 16 3 0.1875 0.0588235294117647
GO:CC GO:0032991 protein-containing complex 0.000157888743541859 5548 88 45 0.511363636363636 0.00811103100216294
GO:CC GO:1990904 ribonucleoprotein complex 0.000217029907081462 688 116 15 0.129310344827586 0.0218023255813953
GO:CC GO:0034451 centriolar satellite 0.000387743902370725 107 110 6 0.0545454545454545 0.0560747663551402
GO:CC GO:0005813 centrosome 0.000492038145119437 619 53 9 0.169811320754717 0.0145395799676898
GO:CC GO:0005815 microtubule organizing center 0.000711579352037611 813 53 10 0.188679245283019 0.01230012300123
GO:CC GO:0035145 exon-exon junction complex 0.00099242709334516 20 88 3 0.0340909090909091 0.15
GO:CC GO:0005684 U2-type spliceosomal complex 0.00101734286114982 93 96 5 0.0520833333333333 0.0537634408602151
GO:CC GO:0015630 microtubule cytoskeleton 0.00187455096856985 1307 53 12 0.226415094339623 0.00918133129303749
GO:CC GO:1902494 catalytic complex 0.0019735406594814 1441 94 18 0.191489361702128 0.0124913254684247
GO:CC GO:0070013 intracellular organelle lumen 0.00197581380291564 5402 88 41 0.465909090909091 0.0075897815623843
GO:CC GO:0043233 organelle lumen 0.00264920703484341 5565 122 54 0.442622950819672 0.00970350404312668
GO:CC GO:0031974 membrane-enclosed lumen 0.00264920703484341 5565 122 54 0.442622950819672 0.00970350404312668
GO:CC GO:0043227 membrane-bounded organelle 0.00861503163286998 12858 100 82 0.82 0.00637735262093638
GO:CC GO:0010494 cytoplasmic stress granule 0.0156820063940696 75 137 4 0.0291970802919708 0.0533333333333333
GO:CC GO:0043226 organelle 0.0175146741644164 14008 100 86 0.86 0.00613934894346088
GO:CC GO:0000228 nuclear chromosome 0.0199984779735767 252 75 5 0.0666666666666667 0.0198412698412698
GO:CC GO:0031248 protein acetyltransferase complex 0.0222754768017291 93 132 4 0.0303030303030303 0.043010752688172
GO:CC GO:0005622 intracellular anatomical structure 0.0222754768017291 14790 123 108 0.878048780487805 0.00730223123732252
GO:CC GO:0005856 cytoskeleton 0.0222754768017291 2332 53 14 0.264150943396226 0.00600343053173242
GO:CC GO:0005801 cis-Golgi network 0.0222754768017291 69 86 3 0.0348837209302326 0.0434782608695652
GO:CC GO:0000793 condensed chromosome 0.0222754768017291 217 130 6 0.0461538461538462 0.0276497695852535
GO:CC GO:1902493 acetyltransferase complex 0.0222754768017291 93 132 4 0.0303030303030303 0.043010752688172
GO:CC GO:0097525 spliceosomal snRNP complex 0.0240640902729828 59 108 3 0.0277777777777778 0.0508474576271186
GO:CC GO:0030532 small nuclear ribonucleoprotein complex 0.0336656840645057 68 108 3 0.0277777777777778 0.0441176470588235
GO:CC GO:0072686 mitotic spindle 0.0411604758753928 159 51 3 0.0588235294117647 0.0188679245283019
GO:CC GO:0043228 non-membrane-bounded organelle 0.0426381246049057 5346 90 36 0.4 0.00673400673400673
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.0426381246049057 5338 90 36 0.4 0.00674409891345073
GO:CC GO:0120114 Sm-like protein family complex 0.0426381246049057 80 108 3 0.0277777777777778 0.0375
GO:CC GO:0000779 condensed chromosome, centromeric region 0.0426381246049057 124 130 4 0.0307692307692308 0.032258064516129
GO:CC GO:0005814 centriole 0.0426381246049057 142 114 4 0.0350877192982456 0.028169014084507
GO:CC GO:0031090 organelle membrane 0.046081924707086 3612 18 8 0.444444444444444 0.00221483942414175
GO:CC GO:0005667 transcription regulator complex 0.0463662210138322 432 84 6 0.0714285714285714 0.0138888888888889
GO:CC GO:0000775 chromosome, centromeric region 0.0489482193899549 204 130 5 0.0384615384615385 0.0245098039215686
GO:MF GO:0009055 electron transfer activity 6.52760663854647e-09 148 16 7 0.4375 0.0472972972972973
GO:MF GO:0003676 nucleic acid binding 1.93351683294313e-05 4276 138 59 0.427536231884058 0.0137979420018709
GO:MF GO:0003723 RNA binding 1.93351683294313e-05 1943 120 33 0.275 0.0169840452907874
GO:MF GO:0015002 heme-copper terminal oxidase activity 6.89988279713287e-05 27 15 3 0.2 0.111111111111111
GO:MF GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 6.89988279713287e-05 27 15 3 0.2 0.111111111111111
GO:MF GO:0016675 oxidoreductase activity, acting on a heme group of donors 6.89988279713287e-05 28 15 3 0.2 0.107142857142857
GO:MF GO:0004129 cytochrome-c oxidase activity 6.89988279713287e-05 27 15 3 0.2 0.111111111111111
GO:MF GO:0016491 oxidoreductase activity 7.30461427871309e-05 771 16 7 0.4375 0.00907911802853437
GO:MF GO:0015078 proton transmembrane transporter activity 0.000215259656274011 125 18 4 0.222222222222222 0.032
GO:MF GO:0050136 NADH dehydrogenase (quinone) activity 0.000227165793697577 46 16 3 0.1875 0.0652173913043478
GO:MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 0.000227165793697577 46 16 3 0.1875 0.0652173913043478
GO:MF GO:0003954 NADH dehydrogenase activity 0.000227165793697577 46 16 3 0.1875 0.0652173913043478
GO:MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity 0.000254104454247737 49 16 3 0.1875 0.0612244897959184
GO:MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 0.000427503145090195 61 16 3 0.1875 0.0491803278688525
GO:MF GO:0097157 pre-mRNA intronic binding 0.00103262100608654 12 116 3 0.0258620689655172 0.25
GO:MF GO:0140097 catalytic activity, acting on DNA 0.00154211065676212 204 127 8 0.062992125984252 0.0392156862745098
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 0.00181711523020813 107 16 3 0.1875 0.0280373831775701
GO:MF GO:1901363 heterocyclic compound binding 0.00262853715940283 6228 138 67 0.485507246376812 0.0107578676942839
GO:MF GO:0097159 organic cyclic compound binding 0.00365495647866446 6309 138 67 0.485507246376812 0.0106197495641148
GO:MF GO:0004536 deoxyribonuclease activity 0.0109895780217935 60 127 4 0.031496062992126 0.0666666666666667
GO:MF GO:0036002 pre-mRNA binding 0.0196578587422354 36 116 3 0.0258620689655172 0.0833333333333333
GO:MF GO:0008080 N-acetyltransferase activity 0.0228378629101943 79 121 4 0.0330578512396694 0.0506329113924051
GO:MF GO:0022890 inorganic cation transmembrane transporter activity 0.0253041445495641 591 18 4 0.222222222222222 0.00676818950930626
GO:MF GO:0003714 transcription corepressor activity 0.026499424860137 187 56 4 0.0714285714285714 0.0213903743315508
GO:MF GO:0003729 mRNA binding 0.0265829265777646 552 98 9 0.0918367346938776 0.016304347826087
GO:MF GO:0004520 endodeoxyribonuclease activity 0.0283847213849574 41 127 3 0.0236220472440945 0.0731707317073171
GO:MF GO:0008324 cation transmembrane transporter activity 0.0288128075805631 639 18 4 0.222222222222222 0.00625978090766823
GO:MF GO:0017069 snRNA binding 0.0288551720497187 46 116 3 0.0258620689655172 0.0652173913043478
GO:MF GO:0004386 helicase activity 0.0350820119430359 162 122 5 0.040983606557377 0.0308641975308642
GO:MF GO:0016407 acetyltransferase activity 0.0350820119430359 101 121 4 0.0330578512396694 0.0396039603960396
GO:MF GO:0016410 N-acyltransferase activity 0.0354787421400388 104 121 4 0.0330578512396694 0.0384615384615385
GO:MF GO:0042393 histone binding 0.0375340953018594 241 87 5 0.0574712643678161 0.020746887966805
GO:MF GO:0003677 DNA binding 0.0377641367995247 2486 123 27 0.219512195121951 0.0108608205953339
GO:MF GO:0140030 modification-dependent protein binding 0.0415808841378931 160 87 4 0.0459770114942529 0.025
GO:MF GO:0034212 peptide N-acetyltransferase activity 0.0431561349286497 61 121 3 0.0247933884297521 0.0491803278688525
GO:MF GO:0015318 inorganic molecular entity transmembrane transporter activity 0.0431561349286497 831 18 4 0.222222222222222 0.00481347773766546
GO:MF GO:0003684 damaged DNA binding 0.0465105238514219 66 119 3 0.0252100840336134 0.0454545454545455
HP HP:0001427 Mitochondrial inheritance 1.02257743406683e-12 18 18 8 0.444444444444444 0.444444444444444
HP HP:0000576 Centrocecal scotoma 3.78155879780398e-12 12 18 7 0.388888888888889 0.583333333333333
HP HP:0004309 Ventricular preexcitation 3.78155879780398e-12 23 18 8 0.444444444444444 0.347826086956522
HP HP:0002572 Episodic vomiting 5.97607597575492e-11 32 18 8 0.444444444444444 0.25
HP HP:0200125 Mitochondrial respiratory chain defects 6.03746468452378e-11 18 18 7 0.388888888888889 0.388888888888889
HP HP:0007763 Retinal telangiectasia 7.94896128996546e-11 19 18 7 0.388888888888889 0.368421052631579
HP HP:0001112 Leber optic atrophy 1.07861355117837e-10 10 18 6 0.333333333333333 0.6
HP HP:0007768 Central retinal vessel vascular tortuosity 1.72008906529328e-10 11 18 6 0.333333333333333 0.545454545454545
HP HP:0000631 Retinal arterial tortuosity 1.72008906529328e-10 11 18 6 0.333333333333333 0.545454545454545
HP HP:0003200 Ragged-red muscle fibers 1.72008906529328e-10 40 18 8 0.444444444444444 0.2
HP HP:0002401 Stroke-like episode 4.38271981875956e-10 15 15 6 0.4 0.4
HP HP:0003737 Mitochondrial myopathy 1.85391229591769e-09 54 18 8 0.444444444444444 0.148148148148148
HP HP:0012766 Widened cerebral subarachnoid space 1.85391229591769e-09 8 15 5 0.333333333333333 0.625
HP HP:0001716 Wolff-Parkinson-White syndrome 1.85391229591769e-09 19 15 6 0.4 0.315789473684211
HP HP:0000622 Blurred vision 1.93614004836359e-09 32 18 7 0.388888888888889 0.21875
HP HP:0007924 Slow decrease in visual acuity 1.93614004836359e-09 32 18 7 0.388888888888889 0.21875
HP HP:0007327 Mixed demyelinating and axonal polyneuropathy 3.22718179245126e-09 9 15 5 0.333333333333333 0.555555555555556
HP HP:0005157 Concentric hypertrophic cardiomyopathy 6.08445280373086e-09 10 15 5 0.333333333333333 0.5
HP HP:0002174 Postural tremor 6.10227169706259e-09 52 22 8 0.363636363636364 0.153846153846154
HP HP:0005116 Arterial tortuosity 6.80941911338588e-09 20 18 6 0.333333333333333 0.3
HP HP:0003800 Muscle abnormality related to mitochondrial dysfunction 8.40326998997935e-09 69 18 8 0.444444444444444 0.115942028985507
HP HP:0012841 Retinal vascular tortuosity 9.22421478156559e-09 41 18 7 0.388888888888889 0.170731707317073
HP HP:0004948 Vascular tortuosity 1.13460195737202e-08 22 18 6 0.333333333333333 0.272727272727273
HP HP:0025268 Stuttering 1.42886258579835e-08 12 15 5 0.333333333333333 0.416666666666667
HP HP:0000603 Central scotoma 1.62436166058511e-08 45 18 7 0.388888888888889 0.155555555555556
HP HP:0007067 Distal peripheral sensory neuropathy 2.13930680744545e-08 13 15 5 0.333333333333333 0.384615384615385
HP HP:0001345 Psychotic mentation 3.19859623097499e-08 14 15 5 0.333333333333333 0.357142857142857
HP HP:0100027 Recurrent pancreatitis 4.61793206301623e-08 15 15 5 0.333333333333333 0.333333333333333
HP HP:0007159 Fluctuations in consciousness 8.84832787785811e-08 17 15 5 0.333333333333333 0.294117647058824
HP HP:0012707 Elevated brain lactate level by MRS 8.84832787785811e-08 17 15 5 0.333333333333333 0.294117647058824
HP HP:0025045 Abnormal brain lactate level by MRS 1.18342492677521e-07 18 15 5 0.333333333333333 0.277777777777778
HP HP:0008316 Abnormal mitochondria in muscle tissue 1.26996960966678e-07 38 16 6 0.375 0.157894736842105
HP HP:0012429 Aplasia/Hypoplasia of the cerebral white matter 1.5059297473235e-07 19 15 5 0.333333333333333 0.263157894736842
HP HP:0004308 Ventricular arrhythmia 1.73761217404508e-07 106 18 8 0.444444444444444 0.0754716981132075
HP HP:0007141 Sensorimotor neuropathy 3.55228966950857e-07 72 18 7 0.388888888888889 0.0972222222222222
HP HP:0004389 Intestinal pseudo-obstruction 3.96501556032959e-07 23 15 5 0.333333333333333 0.217391304347826
HP HP:0000575 Scotoma 4.08717314670657e-07 74 18 7 0.388888888888889 0.0945945945945946
HP HP:0000114 Proximal tubulopathy 4.66318565257055e-07 48 16 6 0.375 0.125
HP HP:0031546 Cardiac conduction abnormality 4.9981743772218e-07 123 18 8 0.444444444444444 0.0650406504065041
HP HP:0001045 Vitiligo 5.61351894610924e-07 25 15 5 0.333333333333333 0.2
HP HP:0002331 Recurrent paroxysmal headache 6.60678001472592e-07 26 15 5 0.333333333333333 0.192307692307692
HP HP:0000590 Progressive external ophthalmoplegia 6.60678001472592e-07 26 15 5 0.333333333333333 0.192307692307692
HP HP:0010794 Impaired visuospatial constructive cognition 1.15850455357279e-06 29 15 5 0.333333333333333 0.172413793103448
HP HP:0003287 Abnormality of mitochondrial metabolism 1.17229298528464e-06 139 18 8 0.444444444444444 0.0575539568345324
HP HP:0012103 Abnormality of the mitochondrion 1.38420275955692e-06 163 22 9 0.409090909090909 0.0552147239263804
HP HP:0002490 Increased CSF lactate 1.38420275955692e-06 91 18 7 0.388888888888889 0.0769230769230769
HP HP:0030085 Abnormal CSF lactate level 1.38420275955692e-06 91 18 7 0.388888888888889 0.0769230769230769
HP HP:0000630 Abnormal retinal artery morphology 1.38420275955692e-06 52 18 6 0.333333333333333 0.115384615384615
HP HP:0012705 Abnormal metabolic brain imaging by MRS 1.71432813201054e-06 32 15 5 0.333333333333333 0.15625
HP HP:0007302 Bipolar affective disorder 2.29544757406916e-06 34 15 5 0.333333333333333 0.147058823529412
HP HP:0001138 Optic neuropathy 2.29544757406916e-06 57 18 6 0.333333333333333 0.105263157894737
HP HP:0100611 Multiple glomerular cysts 2.39086775327665e-06 11 18 4 0.222222222222222 0.363636363636364
HP HP:0100754 Mania 2.39086775327665e-06 35 15 5 0.333333333333333 0.142857142857143
HP HP:0003572 Low plasma citrulline 2.39086775327665e-06 11 18 4 0.222222222222222 0.363636363636364
HP HP:0001271 Polyneuropathy 2.39086775327665e-06 58 18 6 0.333333333333333 0.103448275862069
HP HP:0002135 Basal ganglia calcification 2.39086775327665e-06 35 15 5 0.333333333333333 0.142857142857143
HP HP:0000529 Progressive visual loss 2.39086775327665e-06 101 18 7 0.388888888888889 0.0693069306930693
HP HP:0000408 Progressive sensorineural hearing impairment 2.69117703356054e-06 36 15 5 0.333333333333333 0.138888888888889
HP HP:0000829 Hypoparathyroidism 3.05322400328717e-06 37 15 5 0.333333333333333 0.135135135135135
HP HP:3000036 Abnormality of head blood vessel 3.96638023315408e-06 64 18 6 0.333333333333333 0.09375
HP HP:0025454 Abnormal CSF metabolite level 4.05291320747916e-06 110 18 7 0.388888888888889 0.0636363636363636
HP HP:0003546 Exercise intolerance 4.84348898253979e-06 82 15 6 0.4 0.0731707317073171
HP HP:0012377 Hemianopia 4.87924194811842e-06 41 15 5 0.333333333333333 0.121951219512195
HP HP:0001269 Hemiparesis 5.82991571846589e-06 85 15 6 0.4 0.0705882352941176
HP HP:0011965 Abnormal circulating citrulline concentration 5.87119688159649e-06 14 18 4 0.222222222222222 0.285714285714286
HP HP:0000751 Personality changes 5.87119688159649e-06 43 15 5 0.333333333333333 0.116279069767442
HP HP:0003648 Lacticaciduria 5.87119688159649e-06 14 18 4 0.222222222222222 0.285714285714286
HP HP:0001730 Progressive hearing impairment 6.51431110045567e-06 44 15 5 0.333333333333333 0.113636363636364
HP HP:0004303 Abnormal muscle fiber morphology 6.90465891069572e-06 205 22 9 0.409090909090909 0.0439024390243902
HP HP:0000097 Focal segmental glomerulosclerosis 6.90852309694571e-06 45 15 5 0.333333333333333 0.111111111111111
HP HP:0100651 Type I diabetes mellitus 6.90852309694571e-06 45 15 5 0.333333333333333 0.111111111111111
HP HP:0002922 Increased CSF protein 6.90852309694571e-06 45 15 5 0.333333333333333 0.111111111111111
HP HP:0002483 Bulbar signs 6.93757387442168e-06 30 22 5 0.227272727272727 0.166666666666667
HP HP:0000816 Abnormality of Krebs cycle metabolism 7.19521650287596e-06 15 18 4 0.222222222222222 0.266666666666667
HP HP:0025456 Abnormal CSF protein level 8.29572247873686e-06 47 15 5 0.333333333333333 0.106382978723404
HP HP:0008619 Bilateral sensorineural hearing impairment 9.93064297966647e-06 62 22 6 0.272727272727273 0.0967741935483871
HP HP:0001123 Visual field defect 1.11347473593115e-05 199 18 8 0.444444444444444 0.0402010050251256
HP HP:0004885 Episodic respiratory distress 1.16928131905999e-05 17 18 4 0.222222222222222 0.235294117647059
HP HP:0003481 Segmental peripheral demyelination/remyelination 1.16928131905999e-05 17 18 4 0.222222222222222 0.235294117647059
HP HP:0001009 Telangiectasia 1.25701002082655e-05 135 18 7 0.388888888888889 0.0518518518518519
HP HP:0002345 Action tremor 1.25701002082655e-05 160 22 8 0.363636363636364 0.05
HP HP:0000572 Visual loss 1.41767132912127e-05 207 18 8 0.444444444444444 0.0386473429951691
HP HP:0000726 Dementia 1.47582713814494e-05 164 22 8 0.363636363636364 0.0487804878048781
HP HP:0003128 Lactic acidosis 1.53991547899395e-05 161 16 7 0.4375 0.0434782608695652
HP HP:0002076 Migraine 1.55979484527913e-05 105 15 6 0.4 0.0571428571428571
HP HP:0000544 External ophthalmoplegia 1.61420247835233e-05 55 15 5 0.333333333333333 0.0909090909090909
HP HP:0000580 Pigmentary retinopathy 1.61420247835233e-05 151 24 8 0.333333333333333 0.0529801324503311
HP HP:0001644 Dilated cardiomyopathy 1.8661218117592e-05 145 18 7 0.388888888888889 0.0482758620689655
HP HP:0000124 Renal tubular dysfunction 1.8661218117592e-05 101 16 6 0.375 0.0594059405940594
HP HP:0002579 Gastrointestinal dysmotility 1.87925478476388e-05 71 22 6 0.272727272727273 0.0845070422535211
HP HP:0030895 Abnormal gastrointestinal motility 1.87925478476388e-05 71 22 6 0.272727272727273 0.0845070422535211
HP HP:0031434 Abnormal speech prosody 2.02868099405667e-05 20 18 4 0.222222222222222 0.2
HP HP:0011767 Abnormality of the parathyroid physiology 2.97505002568082e-05 63 15 5 0.333333333333333 0.0793650793650794
HP HP:0000095 Abnormal renal glomerulus morphology 3.13711277673771e-05 158 18 7 0.388888888888889 0.0443037974683544
HP HP:0031263 Abnormal renal corpuscle morphology 3.13711277673771e-05 158 18 7 0.388888888888889 0.0443037974683544
HP HP:0033109 Abnormal circulating non-proteinogenic amino acid concentration 3.52665532090568e-05 23 18 4 0.222222222222222 0.173913043478261
HP HP:0002381 Aphasia 5.20488945896998e-05 71 15 5 0.333333333333333 0.0704225352112676
HP HP:0002151 Increased serum lactate 5.40180530399513e-05 172 18 7 0.388888888888889 0.0406976744186047
HP HP:0000828 Abnormality of the parathyroid gland 6.54927976499309e-05 75 15 5 0.333333333333333 0.0666666666666667
HP HP:0001297 Stroke 6.54927976499309e-05 138 15 6 0.4 0.0434782608695652
HP HP:0002883 Hyperventilation 6.54927976499309e-05 27 18 4 0.222222222222222 0.148148148148148
HP HP:0000096 Glomerular sclerosis 6.54927976499309e-05 75 15 5 0.333333333333333 0.0666666666666667
HP HP:0002069 Bilateral tonic-clonic seizure 6.63536931452722e-05 261 18 8 0.444444444444444 0.0306513409961686
HP HP:0001733 Pancreatitis 6.82409982185444e-05 76 15 5 0.333333333333333 0.0657894736842105
HP HP:0002013 Vomiting 7.09665071359982e-05 264 18 8 0.444444444444444 0.0303030303030303
HP HP:0005162 Abnormal left ventricular function 7.14686016743212e-05 77 15 5 0.333333333333333 0.0649350649350649
HP HP:0011035 Abnormal renal cortex morphology 8.68012364716859e-05 187 18 7 0.388888888888889 0.0374331550802139
HP HP:0001712 Left ventricular hypertrophy 9.50833396521203e-05 82 15 5 0.333333333333333 0.0609756097560976
HP HP:0002045 Hypothermia 9.50833396521203e-05 30 18 4 0.222222222222222 0.133333333333333
HP HP:0000597 Ophthalmoparesis 0.000108428271799695 281 18 8 0.444444444444444 0.0284697508896797
HP HP:0012704 Widened subarachnoid space 0.000132554831758273 88 15 5 0.333333333333333 0.0568181818181818
HP HP:0003198 Myopathy 0.000133722189365549 290 18 8 0.444444444444444 0.0275862068965517
HP HP:0002134 Abnormality of the basal ganglia 0.000133722189365549 201 18 7 0.388888888888889 0.0348258706467662
HP HP:0008046 Abnormal retinal vascular morphology 0.000139669962315617 208 24 8 0.333333333333333 0.0384615384615385
HP HP:0001945 Fever 0.000145589844698057 294 18 8 0.444444444444444 0.0272108843537415
HP HP:0030872 Abnormal cardiac ventricular function 0.00014972215976313 91 15 5 0.333333333333333 0.0549450549450549
HP HP:0012575 Abnormal nephron morphology 0.000161466410761796 208 18 7 0.388888888888889 0.0336538461538462
HP HP:0410263 Brain imaging abnormality 0.000182003334929474 95 15 5 0.333333333333333 0.0526315789473684
HP HP:0003348 Hyperalaninemia 0.000204882626862249 37 18 4 0.222222222222222 0.108108108108108
HP HP:0000112 Nephropathy 0.000208584929328442 98 15 5 0.333333333333333 0.0510204081632653
HP HP:0003477 Peripheral axonal neuropathy 0.00021483877413239 141 18 6 0.333333333333333 0.0425531914893617
HP HP:0010916 Abnormal circulating alanine concentration 0.000220985057909597 38 18 4 0.222222222222222 0.105263157894737
HP HP:0010915 Abnormal circulating pyruvate family amino acid concentration 0.000220985057909597 38 18 4 0.222222222222222 0.105263157894737
HP HP:0001711 Abnormal left ventricle morphology 0.00024571471601935 102 15 5 0.333333333333333 0.0490196078431373
HP HP:0001298 Encephalopathy 0.000260409940901373 260 16 7 0.4375 0.0269230769230769
HP HP:0007183 Focal T2 hyperintense basal ganglia lesion 0.000263888788765075 40 18 4 0.222222222222222 0.1
HP HP:0000709 Psychosis 0.000263888788765075 104 15 5 0.333333333333333 0.0480769230769231
HP HP:0003829 Incomplete penetrance 0.000290136520950199 150 18 6 0.333333333333333 0.04
HP HP:0007108 Demyelinating peripheral neuropathy 0.000316318303280341 42 18 4 0.222222222222222 0.0952380952380952
HP HP:0001941 Acidosis 0.000339836888023033 335 18 8 0.444444444444444 0.0238805970149254
HP HP:0002315 Headache 0.000370710703241806 240 18 7 0.388888888888889 0.0291666666666667
HP HP:0010783 Erythema 0.00038099830823731 113 15 5 0.333333333333333 0.0442477876106195
HP HP:0001639 Hypertrophic cardiomyopathy 0.000406872022095889 244 18 7 0.388888888888889 0.0286885245901639
HP HP:0004374 Hemiplegia/hemiparesis 0.000416405133221405 199 15 6 0.4 0.0301507537688442
HP HP:0011096 Peripheral demyelination 0.000472162522575857 47 18 4 0.222222222222222 0.0851063829787234
HP HP:0033108 Abnormal circulating proteinogenic amino acid derivative concentration 0.000472162522575857 47 18 4 0.222222222222222 0.0851063829787234
HP HP:0001714 Ventricular hypertrophy 0.000472266669855756 119 15 5 0.333333333333333 0.0420168067226891
HP HP:0012703 Abnormal subarachnoid space morphology 0.000529116683952245 122 15 5 0.333333333333333 0.040983606557377
HP HP:0002354 Memory impairment 0.000531247248577598 123 15 5 0.333333333333333 0.040650406504065
HP HP:0002092 Pulmonary arterial hypertension 0.000531247248577598 123 15 5 0.333333333333333 0.040650406504065
HP HP:0002514 Cerebral calcification 0.000531247248577598 123 15 5 0.333333333333333 0.040650406504065
HP HP:0033578 Pre-capillary pulmonary hypertension 0.000531247248577598 123 15 5 0.333333333333333 0.040650406504065
HP HP:0004890 Elevated pulmonary artery pressure 0.000531247248577598 123 15 5 0.333333333333333 0.040650406504065
HP HP:0004360 Abnormality of acid-base homeostasis 0.000553257863137168 363 18 8 0.444444444444444 0.0220385674931129
HP HP:0012751 Abnormal basal ganglia MRI signal intensity 0.000567515406369145 50 18 4 0.222222222222222 0.08
HP HP:0000764 Peripheral axonal degeneration 0.000574947068401093 173 18 6 0.333333333333333 0.0346820809248555
HP HP:0000519 Developmental cataract 0.000580818777835479 126 15 5 0.333333333333333 0.0396825396825397
HP HP:0000763 Sensory neuropathy 0.000756078947544318 182 18 6 0.333333333333333 0.032967032967033
HP HP:0011675 Arrhythmia 0.000760836072819526 381 18 8 0.444444444444444 0.020997375328084
HP HP:0012091 Abnormality of pancreas physiology 0.000823159456230172 136 15 5 0.333333333333333 0.0367647058823529
HP HP:0001268 Mental deterioration 0.000963678635433744 311 22 8 0.363636363636364 0.0257234726688103
HP HP:0000819 Diabetes mellitus 0.000968805287673593 395 18 8 0.444444444444444 0.020253164556962
HP HP:0000044 Hypogonadotropic hypogonadism 0.000993284412890611 142 15 5 0.333333333333333 0.0352112676056338
HP HP:0004370 Abnormality of temperature regulation 0.00100997195328334 398 18 8 0.444444444444444 0.0201005025125628
HP HP:0001952 Glucose intolerance 0.00113797514930816 405 18 8 0.444444444444444 0.0197530864197531
HP HP:0003812 Phenotypic variability 0.00123512405867694 410 18 8 0.444444444444444 0.0195121951219512
HP HP:0000602 Ophthalmoplegia 0.00126696393665511 249 15 6 0.4 0.0240963855421687
HP HP:0030956 Abnormality of cardiovascular system electrophysiology 0.0015518047478582 424 18 8 0.444444444444444 0.0188679245283019
HP HP:0030875 Abnormality of pulmonary circulation 0.00169123294006523 160 15 5 0.333333333333333 0.03125
HP HP:0002017 Nausea and vomiting 0.00171378757902398 442 22 9 0.409090909090909 0.0203619909502262
HP HP:0004372 Reduced consciousness/confusion 0.00186325986253588 366 16 7 0.4375 0.0191256830601093
HP HP:0100659 Abnormality of the cerebral vasculature 0.00186868713583907 269 15 6 0.4 0.0223048327137546
HP HP:0007703 Abnormality of retinal pigmentation 0.00186868713583907 319 18 7 0.388888888888889 0.0219435736677116
HP HP:0008047 Abnormality of the vasculature of the eye 0.00186868713583907 319 18 7 0.388888888888889 0.0219435736677116
HP HP:0005978 Type II diabetes mellitus 0.00192691580441868 169 32 7 0.21875 0.0414201183431953
HP HP:0000093 Proteinuria 0.002042449820905 168 15 5 0.333333333333333 0.0297619047619048
HP HP:0001274 Agenesis of corpus callosum 0.00248109479555279 284 15 6 0.4 0.0211267605633803
HP HP:0020129 Abnormal urine protein level 0.00287037648661382 181 15 5 0.333333333333333 0.0276243093922652
HP HP:0000091 Abnormal renal tubule morphology 0.00310116113900901 80 18 4 0.222222222222222 0.05
HP HP:0011017 Abnormal cellular physiology 0.00331680475356215 485 22 9 0.409090909090909 0.0185567010309278
HP HP:0032943 Abnormal urine pH 0.00351374216178692 83 18 4 0.222222222222222 0.0481927710843374
HP HP:0012072 Aciduria 0.00351374216178692 83 18 4 0.222222222222222 0.0481927710843374
HP HP:0001425 Heterogeneous 0.00371951756913026 259 24 7 0.291666666666667 0.027027027027027
HP HP:0002921 Abnormality of the cerebrospinal fluid 0.00401514667424898 492 18 8 0.444444444444444 0.016260162601626
HP HP:0001635 Congestive heart failure 0.00401514667424898 196 15 5 0.333333333333333 0.0255102040816327
HP HP:0011276 Vascular skin abnormality 0.00404940726961976 493 18 8 0.444444444444444 0.0162271805273834
HP HP:0025354 Abnormal cellular phenotype 0.00407151939937524 501 22 9 0.409090909090909 0.0179640718562874
HP HP:0012469 Infantile spasms 0.00407151939937524 87 18 4 0.222222222222222 0.0459770114942529
HP HP:0100704 Cerebral visual impairment 0.00440390227842693 201 15 5 0.333333333333333 0.0248756218905473
HP HP:0010766 Ectopic calcification 0.00458642915532427 203 15 5 0.333333333333333 0.0246305418719212
HP HP:0000998 Hypertrichosis 0.00621811125569237 217 15 5 0.333333333333333 0.0230414746543779
HP HP:0003130 Abnormal peripheral myelination 0.00653391357919373 99 18 4 0.222222222222222 0.0404040404040404
HP HP:0000648 Optic atrophy 0.00669273428921132 533 18 8 0.444444444444444 0.0150093808630394
HP HP:0002120 Cerebral cortical atrophy 0.00751476837852295 287 18 6 0.333333333333333 0.0209059233449477
HP HP:0004302 Functional motor deficit 0.00845814322736006 437 22 8 0.363636363636364 0.0183066361556064
HP HP:0001337 Tremor 0.00934255094365695 518 38 12 0.315789473684211 0.0231660231660232
HP HP:0030163 Abnormal vascular physiology 0.0111214869528779 248 15 5 0.333333333333333 0.0201612903225806
HP HP:0001328 Specific learning disability 0.0112673358540413 249 15 5 0.333333333333333 0.0200803212851406
HP HP:0010549 Weakness due to upper motor neuron dysfunction 0.011519018076264 459 22 8 0.363636363636364 0.0174291938997821
HP HP:0007359 Focal-onset seizure 0.0119666219176572 253 15 5 0.333333333333333 0.0197628458498024
HP HP:0011014 Abnormal glucose homeostasis 0.0119666219176572 584 18 8 0.444444444444444 0.0136986301369863
HP HP:0009830 Peripheral neuropathy 0.0124662508769291 588 18 8 0.444444444444444 0.0136054421768707
HP HP:0003112 Abnormal circulating amino acid concentration 0.0127524000749065 120 18 4 0.222222222222222 0.0333333333333333
HP HP:0001336 Myoclonus 0.0140302850270921 326 18 6 0.333333333333333 0.0184049079754601
HP HP:0001732 Abnormality of the pancreas 0.0141720757286106 264 15 5 0.333333333333333 0.0189393939393939
HP HP:0001638 Cardiomyopathy 0.0154838993214489 463 18 7 0.388888888888889 0.0151187904967603
HP HP:0012447 Abnormal myelination 0.0187164246787183 497 22 8 0.363636363636364 0.0160965794768612
HP HP:0000821 Hypothyroidism 0.0190948740369417 283 15 5 0.333333333333333 0.0176678445229682
HP HP:0007700 Ocular anterior segment dysgenesis 0.019608856344617 285 15 5 0.333333333333333 0.0175438596491228
HP HP:0001637 Abnormal myocardium morphology 0.0203874915374781 487 18 7 0.388888888888889 0.0143737166324435
HP HP:0012795 Abnormality of the optic disc 0.0204549846697772 638 18 8 0.444444444444444 0.0125391849529781
HP HP:0002926 Abnormality of thyroid physiology 0.0224296445794379 295 15 5 0.333333333333333 0.0169491525423729
HP HP:0003828 Variable expressivity 0.023002780394027 297 15 5 0.333333333333333 0.0168350168350168
HP HP:0001399 Hepatic failure 0.0230332605371427 143 18 4 0.222222222222222 0.027972027972028
HP HP:0002123 Generalized myoclonic seizure 0.0247399053953172 146 18 4 0.222222222222222 0.0273972602739726
HP HP:0000822 Hypertension 0.0258900504721422 306 15 5 0.333333333333333 0.0163398692810458
HP HP:0002014 Diarrhea 0.0276858373544772 311 15 5 0.333333333333333 0.0160771704180064
HP HP:0000739 Anxiety 0.0304035051198218 318 15 5 0.333333333333333 0.0157232704402516
HP HP:0000716 Depressivity 0.0346795711120489 328 15 5 0.333333333333333 0.0152439024390244
HP HP:0002019 Constipation 0.0364013387467466 332 15 5 0.333333333333333 0.0150602409638554
HP HP:0002098 Respiratory distress 0.0367381464911184 164 18 4 0.222222222222222 0.024390243902439
HP HP:0100852 Abnormal fear/anxiety-related behavior 0.0384993535121639 337 15 5 0.333333333333333 0.0148367952522255
HP HP:0032794 Myoclonic seizure 0.0388617973218809 167 18 4 0.222222222222222 0.0239520958083832
HP HP:0011097 Epileptic spasm 0.0405374477032131 170 18 4 0.222222222222222 0.0235294117647059
HP HP:0032263 Increased blood pressure 0.0439637557090694 350 15 5 0.333333333333333 0.0142857142857143
HP HP:0011344 Severe global developmental delay 0.0445410254770668 175 18 4 0.222222222222222 0.0228571428571429
HP HP:0032677 Generalized-onset motor seizure 0.0498342753025424 181 18 4 0.222222222222222 0.0220994475138122
HP HP:0000587 Abnormality of the optic nerve 0.0498342753025424 743 18 8 0.444444444444444 0.0107671601615074
HPA HPA:0540053 stomach 1; glandular cells[High] 0.0082652430096449 2365 98 38 0.387755102040816 0.0160676532769556
HPA HPA:0570782 testis; preleptotene spermatocytes[≥Medium] 0.0082652430096449 1280 96 26 0.270833333333333 0.0203125
HPA HPA:0110223 cervix, uterine; squamous epithelial cells[High] 0.0082652430096449 986 108 23 0.212962962962963 0.0233265720081136
HPA HPA:0600223 tonsil; squamous epithelial cells[High] 0.0082652430096449 1442 96 27 0.28125 0.0187239944521498
HPA HPA:0160253 endometrium 1; cells in endometrial stroma[High] 0.0082652430096449 393 96 13 0.135416666666667 0.0330788804071247
HPA HPA:0620223 vagina; squamous epithelial cells[High] 0.0082652430096449 1091 111 25 0.225225225225225 0.0229147571035747
HPA HPA:0090183 cerebellum; cells in granular layer[High] 0.0082652430096449 709 25 8 0.32 0.0112834978843441
HPA HPA:0110053 cervix, uterine; glandular cells[High] 0.00864440310676418 1135 111 25 0.225225225225225 0.0220264317180617
HPA HPA:0170252 endometrium 2; cells in endometrial stroma[≥Medium] 0.00864440310676418 1722 97 30 0.309278350515464 0.0174216027874564
HPA HPA:0241102 heart muscle; cardiomyocytes[≥Medium] 0.00894885620820875 4249 34 24 0.705882352941177 0.00564838785596611
HPA HPA:0330223 oral mucosa; squamous epithelial cells[High] 0.00894885620820875 1112 96 22 0.229166666666667 0.0197841726618705
HPA HPA:0460643 skin 1; Langerhans[High] 0.00894885620820875 734 96 17 0.177083333333333 0.0231607629427793
HPA HPA:0470683 skin 2; epidermal cells[High] 0.0112480145185621 1346 115 28 0.243478260869565 0.0208023774145617
HPA HPA:0460642 skin 1; Langerhans[≥Medium] 0.0117416463590939 3123 30 18 0.6 0.00576368876080692
HPA HPA:0380513 placenta; decidual cells[High] 0.0117416463590939 1144 67 17 0.253731343283582 0.0148601398601399
HPA HPA:0460662 skin 1; keratinocytes[≥Medium] 0.0117416463590939 3893 98 52 0.530612244897959 0.0133573079886977
HPA HPA:0100133 cerebral cortex; neuronal cells[High] 0.0117416463590939 1785 30 13 0.433333333333333 0.00728291316526611
HPA HPA:0570802 testis; sertoli cells[≥Medium] 0.0117416463590939 1662 56 19 0.339285714285714 0.0114320096269555
HPA HPA:0570772 testis; peritubular cells[≥Medium] 0.0117416463590939 440 96 12 0.125 0.0272727272727273
HPA HPA:0090162 cerebellum; Purkinje cells[≥Medium] 0.0119592319314015 4047 27 19 0.703703703703704 0.00469483568075117
HPA HPA:0610833 urinary bladder; urothelial cells[High] 0.0122585222334646 1969 116 36 0.310344827586207 0.0182833925850686
HPA HPA:0570763 testis; pachytene spermatocytes[High] 0.0135462811097422 822 96 17 0.177083333333333 0.0206812652068127
HPA HPA:0390052 prostate; glandular cells[≥Medium] 0.0135462811097422 4699 37 26 0.702702702702703 0.00553309214726538
HPA HPA:0490693 smooth muscle; smooth muscle cells[High] 0.0135462811097422 589 67 11 0.164179104477612 0.0186757215619694
HPA HPA:0340463 ovary; ovarian stroma cells[High] 0.0135462811097422 349 94 10 0.106382978723404 0.0286532951289398
HPA HPA:0570771 testis; peritubular cells[≥Low] 0.0135462811097422 616 96 14 0.145833333333333 0.0227272727272727
HPA HPA:0100123 cerebral cortex; glial cells[High] 0.0135462811097422 683 59 11 0.186440677966102 0.0161054172767204
HPA HPA:0090182 cerebellum; cells in granular layer[≥Medium] 0.0135462811097422 2854 29 16 0.551724137931034 0.00560616678346181
HPA HPA:0170253 endometrium 2; cells in endometrial stroma[High] 0.0135462811097422 326 25 5 0.2 0.0153374233128834
HPA HPA:0360053 parathyroid gland; glandular cells[High] 0.0135462811097422 1486 29 11 0.379310344827586 0.00740242261103634
HPA HPA:0600433 tonsil; germinal center cells[High] 0.0135462811097422 1179 25 9 0.36 0.00763358778625954
HPA HPA:0160252 endometrium 1; cells in endometrial stroma[≥Medium] 0.0135462811097422 2142 97 33 0.34020618556701 0.015406162464986
HPA HPA:0040083 bone marrow; hematopoietic cells[High] 0.0135462811097422 1376 96 24 0.25 0.0174418604651163
HPA HPA:0570783 testis; preleptotene spermatocytes[High] 0.0135462811097422 603 94 14 0.148936170212766 0.0232172470978441
HPA HPA:0460663 skin 1; keratinocytes[High] 0.0147024249239137 848 96 17 0.177083333333333 0.0200471698113208
HPA HPA:0460673 skin 1; melanocytes[High] 0.0147024249239137 848 96 17 0.177083333333333 0.0200471698113208
HPA HPA:0050012 breast; adipocytes[≥Medium] 0.0149289881855305 1445 22 9 0.409090909090909 0.00622837370242215
HPA HPA:0090193 cerebellum; cells in molecular layer[High] 0.0149289881855305 874 102 18 0.176470588235294 0.0205949656750572
HPA HPA:0180053 epididymis; glandular cells[High] 0.0149289881855305 1779 96 28 0.291666666666667 0.0157391793142215
HPA HPA:0060853 bronchus; ciliated cells (cell body)[High] 0.0171179642273651 181 51 5 0.0980392156862745 0.0276243093922652
HPA HPA:0620222 vagina; squamous epithelial cells[≥Medium] 0.0177118154525012 3945 122 61 0.5 0.0154626108998733
HPA HPA:0570781 testis; preleptotene spermatocytes[≥Low] 0.0189484636017576 1636 96 26 0.270833333333333 0.0158924205378973
HPA HPA:0570801 testis; sertoli cells[≥Low] 0.0195168477299487 2256 68 25 0.367647058823529 0.0110815602836879
HPA HPA:0080133 caudate; neuronal cells[High] 0.0196013204897039 1059 25 8 0.32 0.00755429650613787
HPA HPA:0510702 soft tissue 2; peripheral nerve[≥Medium] 0.0198453320362648 1477 27 10 0.37037037037037 0.00677048070412999
HPA HPA:0100203 cerebral cortex; endothelial cells[High] 0.0198453320362648 391 26 5 0.192307692307692 0.0127877237851662
HPA HPA:0210053 fallopian tube; glandular cells[High] 0.0198453320362648 1728 111 30 0.27027027027027 0.0173611111111111
HPA HPA:0550053 stomach 2; glandular cells[High] 0.020611281137119 2350 98 34 0.346938775510204 0.014468085106383
HPA HPA:0150053 duodenum; glandular cells[High] 0.0210429495127113 2767 97 38 0.391752577319588 0.0137332851463679
HPA HPA:0500652 soft tissue 1; fibroblasts[≥Medium] 0.0213899682715485 2649 33 16 0.484848484848485 0.00604001510003775
HPA HPA:0291163 liver; cholangiocytes[High] 0.0227035976627466 294 22 4 0.181818181818182 0.0136054421768707
HPA HPA:0301172 lung; alveolar cells[≥Medium] 0.0245482073327147 2863 68 29 0.426470588235294 0.0101292350681104
HPA HPA:0250122 hippocampus; glial cells[≥Medium] 0.0258614787664121 1926 26 11 0.423076923076923 0.00571131879543095
HPA HPA:0130243 colon; peripheral nerve/ganglion[High] 0.0258614787664121 801 58 11 0.189655172413793 0.0137328339575531
HPA HPA:0250121 hippocampus; glial cells[≥Low] 0.0264961220357764 4033 34 21 0.617647058823529 0.00520704190428961
HPA HPA:0170053 endometrium 2; glandular cells[High] 0.0264961220357764 1282 95 21 0.221052631578947 0.016380655226209
HPA HPA:0590053 thyroid gland; glandular cells[High] 0.0266332287915905 1804 96 27 0.28125 0.0149667405764967
HPA HPA:0100122 cerebral cortex; glial cells[≥Medium] 0.0266332287915905 2588 26 13 0.5 0.00502318392581144
HPA HPA:0340453 ovary; follicle cells[High] 0.0281855720766141 579 29 6 0.206896551724138 0.0103626943005181
HPA HPA:0330222 oral mucosa; squamous epithelial cells[≥Medium] 0.0293194875475923 4254 98 52 0.530612244897959 0.0122237893747062
HPA HPA:0340451 ovary; follicle cells[≥Low] 0.0293194875475923 3228 34 18 0.529411764705882 0.00557620817843866
HPA HPA:0380512 placenta; decidual cells[≥Medium] 0.0293194875475923 3463 32 18 0.5625 0.00519780537106555
HPA HPA:0400053 rectum; glandular cells[High] 0.0293194875475923 2687 96 36 0.375 0.0133978414588761
HPA HPA:0090161 cerebellum; Purkinje cells[≥Low] 0.0293194875475923 5460 32 24 0.75 0.0043956043956044
HPA HPA:0530722 spleen; cells in white pulp[≥Medium] 0.0293194875475923 2645 26 13 0.5 0.00491493383742911
HPA HPA:0030073 appendix; lymphoid tissue[High] 0.029718233900002 803 29 7 0.241379310344828 0.0087173100871731
HPA HPA:0570762 testis; pachytene spermatocytes[≥Medium] 0.0303937311085976 1658 96 25 0.260416666666667 0.0150784077201448
HPA HPA:0510701 soft tissue 2; peripheral nerve[≥Low] 0.0307645638580002 3100 33 17 0.515151515151515 0.00548387096774194
HPA HPA:0350472 pancreas; exocrine glandular cells[≥Medium] 0.0307645638580002 5157 37 26 0.702702702702703 0.00504169090556525
HPA HPA:0080132 caudate; neuronal cells[≥Medium] 0.0344597757843523 4022 33 20 0.606060606060606 0.00497265042267529
HPA HPA:0301173 lung; alveolar cells[High] 0.0362134676013749 778 111 16 0.144144144144144 0.0205655526992288
HPA HPA:0320103 nasopharynx; respiratory epithelial cells[High] 0.0366157865505391 1844 37 13 0.351351351351351 0.00704989154013015
HPA HPA:0190222 esophagus; squamous epithelial cells[≥Medium] 0.0366157865505391 4937 37 25 0.675675675675676 0.00506380392951185
HPA HPA:0350473 pancreas; exocrine glandular cells[High] 0.0366157865505391 1879 96 27 0.28125 0.0143693453964875
HPA HPA:0490692 smooth muscle; smooth muscle cells[≥Medium] 0.0366157865505391 3038 29 15 0.517241379310345 0.00493745885450955
HPA HPA:0110222 cervix, uterine; squamous epithelial cells[≥Medium] 0.0375682592019555 3617 118 53 0.449152542372881 0.0146530273707492
HPA HPA:0420053 salivary gland; glandular cells[High] 0.0375682592019555 1418 97 22 0.22680412371134 0.0155148095909732
HPA HPA:0380511 placenta; decidual cells[≥Low] 0.0375682592019555 4716 33 22 0.666666666666667 0.00466497031382528
HPA HPA:0530721 spleen; cells in white pulp[≥Low] 0.0375682592019555 4249 30 19 0.633333333333333 0.00447164038597317
HPA HPA:0050093 breast; myoepithelial cells[High] 0.0375682592019555 798 110 16 0.145454545454545 0.0200501253132832
HPA HPA:0600442 tonsil; non-germinal center cells[≥Medium] 0.0376076681016111 4079 29 18 0.620689655172414 0.00441284628585438
HPA HPA:0100132 cerebral cortex; neuronal cells[≥Medium] 0.0382029587326559 4883 34 23 0.676470588235294 0.0047102191275855
HPA HPA:0340462 ovary; ovarian stroma cells[≥Medium] 0.0398589097948479 2002 96 28 0.291666666666667 0.013986013986014
HPA HPA:0570813 testis; spermatogonia cells[High] 0.0401407316627848 1281 96 20 0.208333333333333 0.0156128024980484
HPA HPA:0440343 skeletal muscle; myocytes[High] 0.0401407316627848 830 108 16 0.148148148148148 0.0192771084337349
HPA HPA:0250133 hippocampus; neuronal cells[High] 0.0401407316627848 1210 56 13 0.232142857142857 0.0107438016528926
HPA HPA:0060103 bronchus; respiratory epithelial cells[High] 0.0401407316627848 1890 37 13 0.351351351351351 0.00687830687830688
HPA HPA:0090932 cerebellum; GLUC cells - nucleus[≥Medium] 0.0401407316627848 90 95 4 0.0421052631578947 0.0444444444444444
HPA HPA:0160052 endometrium 1; glandular cells[≥Medium] 0.0401407316627848 5014 98 58 0.591836734693878 0.0115676106900678
HPA HPA:0090192 cerebellum; cells in molecular layer[≥Medium] 0.0401407316627848 2699 30 14 0.466666666666667 0.00518710633567988
HPA HPA:0310433 lymph node; germinal center cells[High] 0.0420026737702069 908 29 7 0.241379310344828 0.00770925110132159
HPA HPA:0530723 spleen; cells in white pulp[High] 0.0428400460902865 811 25 6 0.24 0.00739827373612824
HPA HPA:0160053 endometrium 1; glandular cells[High] 0.0445638116371078 1413 29 9 0.310344827586207 0.00636942675159236
HPA HPA:0480053 small intestine; glandular cells[High] 0.0449486609349589 2723 96 35 0.364583333333333 0.012853470437018
HPA HPA:0430053 seminal vesicle; glandular cells[High] 0.0460258831728851 1410 95 21 0.221052631578947 0.0148936170212766
HPA HPA:0470682 skin 2; epidermal cells[≥Medium] 0.0460258831728851 4735 30 20 0.666666666666667 0.00422386483632524
HPA HPA:0050092 breast; myoepithelial cells[≥Medium] 0.0477985945359925 3700 37 20 0.540540540540541 0.00540540540540541
HPA HPA:0090931 cerebellum; GLUC cells - nucleus[≥Low] 0.0477985945359925 98 95 4 0.0421052631578947 0.0408163265306122
HPA HPA:0241103 heart muscle; cardiomyocytes[High] 0.0486054186964886 1113 25 7 0.28 0.00628930817610063
HPA HPA:0010012 adipose tissue; adipocytes[≥Medium] 0.0492998389906441 2168 27 11 0.407407407407407 0.00507380073800738
KEGG KEGG:00190 Oxidative phosphorylation 1.14931914136382e-08 133 18 8 0.444444444444444 0.0601503759398496
KEGG KEGG:05415 Diabetic cardiomyopathy 1.685561417295e-07 203 18 8 0.444444444444444 0.0394088669950739
KEGG KEGG:04714 Thermogenesis 3.22067284917215e-07 232 18 8 0.444444444444444 0.0344827586206897
KEGG KEGG:05012 Parkinson disease 4.20675362288054e-07 249 18 8 0.444444444444444 0.0321285140562249
KEGG KEGG:05020 Prion disease 6.90603378587491e-07 273 18 8 0.444444444444444 0.0293040293040293
KEGG KEGG:05016 Huntington disease 1.39639301571529e-06 306 18 8 0.444444444444444 0.0261437908496732
KEGG KEGG:05014 Amyotrophic lateral sclerosis 1.98598750681242e-06 363 22 9 0.409090909090909 0.0247933884297521
KEGG KEGG:05010 Alzheimer disease 4.42526379464436e-06 369 18 8 0.444444444444444 0.021680216802168
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 1.49962396238606e-05 475 22 9 0.409090909090909 0.0189473684210526
KEGG KEGG:04260 Cardiac muscle contraction 0.000103990837938561 87 15 4 0.266666666666667 0.0459770114942529
KEGG KEGG:04932 Non-alcoholic fatty liver disease 0.000802455661110636 150 15 4 0.266666666666667 0.0266666666666667
KEGG KEGG:03015 mRNA surveillance pathway 0.0074760998165699 98 137 7 0.0510948905109489 0.0714285714285714
KEGG KEGG:04723 Retrograde endocannabinoid signaling 0.0143278455843352 148 16 3 0.1875 0.0202702702702703
KEGG KEGG:03040 Spliceosome 0.018595840119624 150 108 7 0.0648148148148148 0.0466666666666667
KEGG KEGG:03013 RNA transport 0.0326009083265867 180 55 5 0.0909090909090909 0.0277777777777778
KEGG KEGG:01100 Metabolic pathways 0.0421263944426284 1490 18 8 0.444444444444444 0.00536912751677852
MIRNA MIRNA:hsa-let-7c-5p hsa-let-7c-5p 0.00174011603633115 514 18 7 0.388888888888889 0.0136186770428016
MIRNA MIRNA:hsa-miR-181d-5p hsa-miR-181d-5p 0.00223798312350696 283 90 10 0.111111111111111 0.0353356890459364
MIRNA MIRNA:hsa-miR-744-5p hsa-miR-744-5p 0.00223798312350696 435 18 6 0.333333333333333 0.0137931034482759
MIRNA MIRNA:hsa-miR-181b-5p hsa-miR-181b-5p 0.00223798312350696 370 94 12 0.127659574468085 0.0324324324324324
MIRNA MIRNA:hsa-miR-296-3p hsa-miR-296-3p 0.00223798312350696 255 27 6 0.222222222222222 0.0235294117647059
MIRNA MIRNA:hsa-miR-652-3p hsa-miR-652-3p 0.00375872260549748 162 15 4 0.266666666666667 0.0246913580246914
MIRNA MIRNA:hsa-miR-320a hsa-miR-320a 0.00833528832605557 584 44 9 0.204545454545455 0.0154109589041096
MIRNA MIRNA:hsa-miR-181c-5p hsa-miR-181c-5p 0.00860676520835113 286 90 9 0.1 0.0314685314685315
MIRNA MIRNA:hsa-let-7e-5p hsa-let-7e-5p 0.00860676520835113 608 18 6 0.333333333333333 0.00986842105263158
MIRNA MIRNA:hsa-miR-664a-3p hsa-miR-664a-3p 0.00983276180903329 91 115 6 0.0521739130434783 0.0659340659340659
MIRNA MIRNA:hsa-miR-200c-3p hsa-miR-200c-3p 0.0198551519319936 214 20 4 0.2 0.0186915887850467
MIRNA MIRNA:hsa-miR-1301-3p hsa-miR-1301-3p 0.0198551519319936 196 9 3 0.333333333333333 0.0153061224489796
MIRNA MIRNA:hsa-miR-218-5p hsa-miR-218-5p 0.0282923851582848 814 98 15 0.153061224489796 0.0184275184275184
MIRNA MIRNA:hsa-let-7b-5p hsa-let-7b-5p 0.032144247657093 1212 18 7 0.388888888888889 0.00577557755775578
MIRNA MIRNA:hsa-miR-320c hsa-miR-320c 0.0400464287032808 108 21 3 0.142857142857143 0.0277777777777778
MIRNA MIRNA:hsa-miR-1180-3p hsa-miR-1180-3p 0.0402952144299945 67 81 4 0.0493827160493827 0.0597014925373134
MIRNA MIRNA:hsa-miR-21-5p hsa-miR-21-5p 0.0462208568380093 607 71 10 0.140845070422535 0.0164744645799012
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 3.28379114947207e-09 124 18 8 0.444444444444444 0.0645161290322581
REAC REAC:R-HSA-611105 Respiratory electron transport 8.45833653074554e-09 100 16 7 0.4375 0.07
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 1.68633386486634e-08 174 18 8 0.444444444444444 0.0459770114942529
REAC REAC:R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.00195209477366606 235 108 11 0.101851851851852 0.0468085106382979
REAC REAC:R-HSA-6799198 Complex I biogenesis 0.00407278995118156 55 16 3 0.1875 0.0545454545454545
REAC REAC:R-HSA-5628897 TP53 Regulates Metabolic Genes 0.00946422418531542 83 15 3 0.2 0.036144578313253
REAC REAC:R-HSA-72172 mRNA Splicing 0.00999508235789863 186 94 8 0.0851063829787234 0.043010752688172
REAC REAC:R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 0.0243623792537722 69 108 5 0.0462962962962963 0.072463768115942
REAC REAC:R-HSA-72163 mRNA Splicing - Major Pathway 0.0326440320134248 178 94 7 0.074468085106383 0.0393258426966292
REAC REAC:R-HSA-72202 Transport of Mature Transcript to Cytoplasm 0.0340420297998606 78 108 5 0.0462962962962963 0.0641025641025641
REAC REAC:R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 0.0404105419958827 80 114 5 0.043859649122807 0.0625
REAC REAC:R-HSA-380287 Centrosome maturation 0.0404105419958827 80 114 5 0.043859649122807 0.0625
REAC REAC:R-HSA-1852241 Organelle biogenesis and maintenance 0.0489469643448323 293 49 6 0.122448979591837 0.0204778156996587
TF TF:M07234 Factor: YY1; motif: CAARATGGCNGC 0.000917506792727926 6045 129 68 0.527131782945736 0.0112489660876758
TF TF:M01165_1 Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 0.00113290792452183 2185 120 33 0.275 0.0151029748283753
TF TF:M01035 Factor: YY1; motif: NYNKCCATNTT 0.00113290792452183 5924 129 66 0.511627906976744 0.0111411208642809
TF TF:M12238 Factor: DREF; motif: MTRTCGCGAYAK 0.0011836995906685 350 134 13 0.0970149253731343 0.0371428571428571
TF TF:M08320 Factor: GCMa:HOXB13; motif: RTGCGGGTMATAAAN 0.0011836995906685 837 21 8 0.380952380952381 0.00955794504181601
TF TF:M00793 Factor: YY1; motif: GCCATNTTN 0.0011836995906685 5186 95 47 0.494736842105263 0.00906286155032781
TF TF:M08320_1 Factor: GCMa:HOXB13; motif: RTGCGGGTMATAAAN; match class: 1 0.0011836995906685 22 18 3 0.166666666666667 0.136363636363636
TF TF:M10104 Factor: YY1; motif: CAARATGGCGGC 0.00142263772117435 6071 129 65 0.503875968992248 0.0107066381156317
TF TF:M11434_1 Factor: Elk-1; motif: NRSCGGAAGNN; match class: 1 0.00142263772117435 2935 138 42 0.304347826086957 0.0143100511073254
TF TF:M08319 Factor: GCMa:HOXA13; motif: RTGCGGGTAATAAA 0.00142263772117435 455 18 6 0.333333333333333 0.0131868131868132
TF TF:M10584 Factor: Barhl2; motif: NTAAACGN 0.00142263772117435 1886 121 29 0.239669421487603 0.0153764581124072
TF TF:M03924 Factor: YY1; motif: NNCGCCATTNN 0.00142263772117435 10084 49 41 0.836734693877551 0.00406584688615629
TF TF:M08982 Factor: YY1; motif: NAANATGGCGNNN 0.00193030298686739 7125 129 72 0.558139534883721 0.0101052631578947
TF TF:M02070_1 Factor: TEL1; motif: CNCGGAANNN; match class: 1 0.00212975642002781 4841 138 58 0.420289855072464 0.0119809956620533
TF TF:M12238_1 Factor: DREF; motif: MTRTCGCGAYAK; match class: 1 0.00215152480227905 293 134 11 0.082089552238806 0.037542662116041
TF TF:M11507 Factor: CDP; motif: NTATTGATYR 0.00215152480227905 3157 28 15 0.535714285714286 0.00475134621476085
TF TF:M08331 Factor: GCMb:FOXI1; motif: RTAAATANGGGNN 0.00340581088905846 45 18 3 0.166666666666667 0.0666666666666667
TF TF:M08704 Factor: GCMa:HOXA2; motif: RTRNGGGYNTAATNN 0.0039416750116647 342 18 5 0.277777777777778 0.0146198830409357
TF TF:M08326 Factor: GCMb:Prrxl1; motif: ATRCGGGTNATTAN 0.00412819263885163 614 18 6 0.333333333333333 0.00977198697068404
TF TF:M12273 Factor: YY1; motif: GGCSGCCATTTTGN 0.00473826605390021 6229 129 64 0.496124031007752 0.010274522395248
TF TF:M09600 Factor: CREB1; motif: TKACGTCAYNN 0.00502929728152255 5324 87 42 0.482758620689655 0.00788880540946657
TF TF:M11432_1 Factor: Elk-1; motif: NACMGGAAGTN; match class: 1 0.00502929728152255 1525 138 26 0.188405797101449 0.0170491803278689
TF TF:M06739 Factor: ZNF358; motif: NTRTGAAGAATM 0.00502929728152255 42 24 3 0.125 0.0714285714285714
TF TF:M11425_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.00502929728152255 2330 120 31 0.258333333333333 0.0133047210300429
TF TF:M08261 Factor: ER71:HOXB13; motif: NNCGGAWGTNGTWAAN 0.00530719150398566 319 11 4 0.363636363636364 0.0125391849529781
TF TF:M10604_1 Factor: Dlx-7; motif: NYAATTAN; match class: 1 0.00539218137498977 45 78 4 0.0512820512820513 0.0888888888888889
TF TF:M02062_1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 0.00539218137498977 2718 120 34 0.283333333333333 0.0125091979396615
TF TF:M02073_1 Factor: Fli-1; motif: ACCGGAAGYN; match class: 1 0.00539218137498977 1488 120 23 0.191666666666667 0.0154569892473118
TF TF:M10611_1 Factor: Dlx-5; motif: NYAATTAN; match class: 1 0.00539218137498977 15 78 3 0.0384615384615385 0.2
TF TF:M10619_1 Factor: Dlx-2; motif: NYAATTAN; match class: 1 0.00539218137498977 45 78 4 0.0512820512820513 0.0888888888888889
TF TF:M04303_1 Factor: Dlx-5; motif: NYAATTAN; match class: 1 0.00539218137498977 45 78 4 0.0512820512820513 0.0888888888888889
TF TF:M10620_1 Factor: Dlx-2; motif: NYAATTAN; match class: 1 0.00539218137498977 45 78 4 0.0512820512820513 0.0888888888888889
TF TF:M02063_1 Factor: c-ets-1; motif: ACCGGAWGTN; match class: 1 0.00539218137498977 2396 120 31 0.258333333333333 0.0129382303839733
TF TF:M12275 Factor: YY1; motif: NGCCGCCATYTTGN 0.00539218137498977 7043 138 73 0.528985507246377 0.01036490132046
TF TF:M10602_1 Factor: Dlx-7; motif: NYAATTAN; match class: 1 0.00539218137498977 45 78 4 0.0512820512820513 0.0888888888888889
TF TF:M11042 Factor: HMBOX1; motif: NCTAGTTAN 0.00539218137498977 138 26 4 0.153846153846154 0.0289855072463768
TF TF:M09605_1 Factor: Elf-1; motif: NAANCMGGAAGTGN; match class: 1 0.00647601199295065 1306 120 21 0.175 0.0160796324655436
TF TF:M00137_1 Factor: Oct-1; motif: NNNRTAATNANNN; match class: 1 0.00681370084261485 2173 44 15 0.340909090909091 0.00690289921767142
TF TF:M07140_1 Factor: Kaiso; motif: NTCTCGCGAGANYTN; match class: 1 0.00681370084261485 189 97 7 0.0721649484536082 0.037037037037037
TF TF:M11448_1 Factor: Elf-1; motif: NANGCGGAAGTN; match class: 1 0.00794135531633491 2324 138 33 0.239130434782609 0.0141996557659208
TF TF:M07052_1 Factor: NRF-1; motif: GCGCMTGCGCN; match class: 1 0.00876723640528194 734 138 16 0.115942028985507 0.0217983651226158
TF TF:M04287 Factor: BARHL2; motif: NNTAAAYGNN 0.00883082351772009 4416 53 25 0.471698113207547 0.00566123188405797
TF TF:M02115_1 Factor: Prx2; motif: TYAWAKTAA; match class: 1 0.00883082351772009 684 30 7 0.233333333333333 0.010233918128655
TF TF:M10578_1 Factor: Barhl-1; motif: NTAAACGN; match class: 1 0.00951456602527495 1391 92 18 0.195652173913043 0.01294033069734
TF TF:M09632 Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN 0.0100850746568993 3001 97 30 0.309278350515464 0.00999666777740753
TF TF:M03970_1 Factor: ELK1; motif: ACCGGAAGTN; match class: 1 0.0106876054466396 1097 138 20 0.144927536231884 0.0182315405651778
TF TF:M02085 Factor: Bcl-6; motif: NTTYCTAGRA 0.0107102660660621 4976 46 24 0.521739130434783 0.00482315112540193
TF TF:M11424_1 Factor: Erm; motif: NNSCGGAWGYN; match class: 1 0.0117337565543943 2835 138 37 0.268115942028986 0.0130511463844797
TF TF:M11620 Factor: Sox-14; motif: CCGAACAATN 0.0117337565543943 538 18 5 0.277777777777778 0.00929368029739777
TF TF:M00916 Factor: CREB; motif: NNTKACGTCANNNS 0.0117337565543943 5889 87 43 0.494252873563218 0.00730174902360333
TF TF:M07370 Factor: YY1; motif: NNNNAARATGGNNNN 0.0117337565543943 5811 48 27 0.5625 0.00464636035105834
TF TF:M01082_1 Factor: BRCA1:USF2; motif: KTNNGTTG; match class: 1 0.013023660419083 1813 44 13 0.295454545454545 0.00717043574186431
TF TF:M11435_1 Factor: Elk-1; motif: NNCCGGAAGTN; match class: 1 0.0132889605373628 5745 138 61 0.442028985507246 0.0106179286335944
TF TF:M10578 Factor: Barhl-1; motif: NTAAACGN 0.0132889605373628 6099 100 49 0.49 0.00803410395146745
TF TF:M08874 Factor: E2F1; motif: NNNNNGCGSSAAAN 0.0133795840685668 7201 138 72 0.521739130434783 0.00999861130398556
TF TF:M00039 Factor: CREB; motif: TGACGTMA 0.0136849408179098 5222 86 39 0.453488372093023 0.00746840291076216
TF TF:M10638_1 Factor: Nkx2-3; motif: NNCGTTRWS; match class: 1 0.0140154366617809 4099 62 26 0.419354838709677 0.0063430104903635
TF TF:M04133 Factor: TBX2; motif: GGTGTGANAWNTSACACC 0.0142863850123307 23 86 3 0.0348837209302326 0.130434782608696
TF TF:M08467 Factor: Erm:HOXB13; motif: RSCGGAWGTNRTWAA 0.0146256636251092 706 33 7 0.212121212121212 0.00991501416430595
TF TF:M10119 Factor: REX-1; motif: GGCMGCCATTTT 0.0147533947642022 1888 55 15 0.272727272727273 0.00794491525423729
TF TF:M02044 Factor: YY1; motif: GCCGCCATTTTG 0.0147533947642022 6102 129 60 0.465116279069767 0.00983284169124877
TF TF:M08760 Factor: ETV7; motif: NNSCGGAAGTR 0.0147533947642022 2349 138 32 0.231884057971014 0.0136228182205194
TF TF:M03925 Factor: YY2; motif: NCCGCCATNTY 0.0149055984475093 4641 132 50 0.378787878787879 0.0107735401853049
TF TF:M09966 Factor: Kaiso; motif: SARNYCTCGCGAGAN 0.0149055984475093 2356 138 32 0.231884057971014 0.0135823429541596
TF TF:M11438 Factor: SAP-1; motif: NTCGTAAATGCN 0.0149055984475093 5901 39 23 0.58974358974359 0.00389764446703948
TF TF:M10785 Factor: hoxa9; motif: RTCGTWANNN 0.014981315679453 5632 139 60 0.431654676258993 0.0106534090909091
TF TF:M00483 Factor: ATF6; motif: TGACGTGG 0.0160221400669764 2627 94 26 0.276595744680851 0.0098972211648268
TF TF:M11422_1 Factor: Erm; motif: NRCMGGAAGTN; match class: 1 0.0160221400669764 934 120 16 0.133333333333333 0.0171306209850107
TF TF:M08278 Factor: Erm:HOXA2; motif: RNCGGAWGTMATTA 0.0167999127738069 124 18 3 0.166666666666667 0.0241935483870968
TF TF:M09641_1 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN; match class: 1 0.0173053305356846 991 138 18 0.130434782608696 0.0181634712411705
TF TF:M03924_1 Factor: YY1; motif: NNCGCCATTNN; match class: 1 0.0183923975901582 3700 132 42 0.318181818181818 0.0113513513513514
TF TF:M11404_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0183923975901582 3171 120 35 0.291666666666667 0.011037527593819
TF TF:M01660_1 Factor: GABP-alpha; motif: CTTCCK; match class: 1 0.0183923975901582 5133 134 54 0.402985074626866 0.0105201636469901
TF TF:M08875 Factor: E2F; motif: NNTTTCGCGCN 0.0183923975901582 6203 139 64 0.460431654676259 0.0103175882637433
TF TF:M04744 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA 0.0183923975901582 10089 95 66 0.694736842105263 0.00654177817424918
TF TF:M01752_1 Factor: ERG; motif: ACCGGAART; match class: 1 0.0186881720178332 3705 120 39 0.325 0.0105263157894737
TF TF:M01013 Factor: ipf1; motif: TSNGYCATTANNNNC 0.0186881720178332 2498 19 9 0.473684210526316 0.00360288230584468
TF TF:M11594 Factor: GCMa; motif: ATGNGGGYR 0.0186881720178332 651 18 5 0.277777777777778 0.00768049155145929
TF TF:M00917 Factor: CREB; motif: CNNTGACGTMA 0.0189872360703464 5578 86 40 0.465116279069767 0.00717102904266762
TF TF:M10635 Factor: Nkx2-3; motif: GNCGTTRAG 0.0189872360703464 4594 49 23 0.469387755102041 0.00500653025685677
TF TF:M03975_1 Factor: ERG; motif: ACCGGAARTN; match class: 1 0.0192175433491116 4024 138 46 0.333333333333333 0.0114314115308151
TF TF:M00456_1 Factor: FAC1; motif: NNNCAMAACACRNA; match class: 1 0.0192175433491116 2699 18 9 0.5 0.00333456835865135
TF TF:M11331 Factor: Hlf; motif: NNTTACGTAANN 0.0192175433491116 543 33 6 0.181818181818182 0.0110497237569061
TF TF:M07052 Factor: NRF-1; motif: GCGCMTGCGCN 0.0201812223077092 2130 111 25 0.225225225225225 0.0117370892018779
TF TF:M01861 Factor: ATF-1; motif: TNACGTCAN 0.0201812223077092 6294 95 47 0.494736842105263 0.00746742929774388
TF TF:M02052_1 Factor: EHF; motif: CSCGGAARTN; match class: 1 0.0214723215327608 4056 134 45 0.335820895522388 0.011094674556213
TF TF:M11225_1 Factor: CREM; motif: NNTGACGTCANN; match class: 1 0.022322454811036 2482 81 22 0.271604938271605 0.0088638195004029
TF TF:M11578_1 Factor: foxl2; motif: NACGTMAACAN; match class: 1 0.022322454811036 960 123 16 0.130081300813008 0.0166666666666667
TF TF:M10635_1 Factor: Nkx2-3; motif: GNCGTTRAG; match class: 1 0.022322454811036 703 49 8 0.163265306122449 0.0113798008534851
TF TF:M10632_1 Factor: Nkx2-8; motif: STCGTTGAN; match class: 1 0.022322454811036 831 42 8 0.19047619047619 0.00962695547533093
TF TF:M09868 Factor: ATF-3; motif: GGTSACGTGAN 0.0234673036516944 6391 92 46 0.5 0.00719762165545298
TF TF:M09641 Factor: NRF-1; motif: SYGCGCMTGCGCRNNGSN 0.0235619107781886 3222 121 35 0.289256198347107 0.010862818125388
TF TF:M10718 Factor: HOXC4; motif: RTCRTTAN 0.0235619107781886 2772 55 18 0.327272727272727 0.00649350649350649
TF TF:M11451_1 Factor: Elf-1; motif: NANCCGGAAGTN; match class: 1 0.0235619107781886 2112 120 26 0.216666666666667 0.0123106060606061
TF TF:M09966_1 Factor: Kaiso; motif: SARNYCTCGCGAGAN; match class: 1 0.0239255557252007 449 97 9 0.0927835051546392 0.0200445434298441
TF TF:M11428_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0239255557252007 2146 138 29 0.210144927536232 0.0135135135135135
TF TF:M12277 Factor: YY2; motif: NKCSGCCATTTTGN 0.0240042406755208 135 138 6 0.0434782608695652 0.0444444444444444
TF TF:M07380 Factor: E2F-4; motif: NTTTCSCGCC 0.0240042406755208 13022 99 81 0.818181818181818 0.0062202426662571
TF TF:M03560_1 Factor: PMX1; motif: TAATHA; match class: 1 0.0241881593700048 10273 36 29 0.805555555555556 0.00282293390440962
TF TF:M10685_1 Factor: HOXB7; motif: NGYAATTANN; match class: 1 0.0241881593700048 728 18 5 0.277777777777778 0.00686813186813187
TF TF:M10611 Factor: Dlx-5; motif: NYAATTAN 0.0243131349907393 473 93 9 0.0967741935483871 0.0190274841437632
TF TF:M00025_1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 0.0246540946147357 4639 120 45 0.375 0.00970036645828842
TF TF:M03970 Factor: ELK1; motif: ACCGGAAGTN 0.0246540946147357 4782 120 46 0.383333333333333 0.0096194061062317
TF TF:M00981_1 Factor: CREB,; motif: NTGACGTNA; match class: 1 0.0254933165733285 2904 95 27 0.284210526315789 0.00929752066115703
TF TF:M07258 Factor: HOXD10; motif: ARGAATAAWAA 0.0255390177722347 849 16 5 0.3125 0.00588928150765607
TF TF:M02059_1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 0.0257996153336084 3759 138 43 0.311594202898551 0.011439212556531
TF TF:M02053_1 Factor: ELF1; motif: NCCGGAARTN; match class: 1 0.025920816575663 1559 120 21 0.175 0.013470173187941
TF TF:M02066_1 Factor: PEA3; motif: RCCGGAAGYN; match class: 1 0.026687991725502 2283 138 30 0.217391304347826 0.0131406044678055
TF TF:M10785_1 Factor: hoxa9; motif: RTCGTWANNN; match class: 1 0.0267526196616144 1160 138 19 0.13768115942029 0.0163793103448276
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.0269467300895119 14593 121 105 0.867768595041322 0.00719523059000891
TF TF:M02102_1 Factor: NRF-1; motif: YGCGCMTGCGC; match class: 1 0.0273799739523426 654 133 13 0.0977443609022556 0.0198776758409786
TF TF:M04696 Factor: YY1; motif: GCCGCCATNTTGNNNNNGGNCN 0.028377106207709 7819 129 70 0.542635658914729 0.00895255147717099
TF TF:M00425_1 Factor: E2F; motif: TTTCGCGC; match class: 1 0.028377106207709 5355 61 29 0.475409836065574 0.00541549953314659
TF TF:M11452_1 Factor: Elf-1; motif: NANGCGGAAGTR; match class: 1 0.028377106207709 1696 120 22 0.183333333333333 0.0129716981132075
TF TF:M10761_1 Factor: MOX1; motif: NTCRTTAN; match class: 1 0.028377106207709 363 21 4 0.19047619047619 0.0110192837465565
TF TF:M12285_1 Factor: ZNF647; motif: NTAGGCCTAN; match class: 1 0.028377106207709 429 18 4 0.222222222222222 0.00932400932400932
TF TF:M11307 Factor: ATF-2; motif: NNTGACGTMANN 0.028377106207709 2085 29 10 0.344827586206897 0.00479616306954436
TF TF:M08982_1 Factor: YY1; motif: NAANATGGCGNNN; match class: 1 0.0284224823617912 1662 24 8 0.333333333333333 0.00481347773766546
TF TF:M11430_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0284708293785733 4902 138 52 0.376811594202899 0.0106079151366789
TF TF:M03988_1 Factor: FLI1; motif: ACCGGAARTN; match class: 1 0.0284708293785733 2950 95 27 0.284210526315789 0.00915254237288136
TF TF:M11420_1 Factor: ER81; motif: NACCGGAAGTN; match class: 1 0.0289671245002273 494 134 11 0.082089552238806 0.0222672064777328
TF TF:M10849_1 Factor: Cdx-2; motif: NRTCGTAANNNN; match class: 1 0.0291547870866566 4497 26 14 0.538461538461538 0.00311318656882366
TF TF:M10736 Factor: HOXA2; motif: RTCRTTAR 0.0294347216512832 1961 21 8 0.380952380952381 0.00407955124936257
TF TF:M10436 Factor: YY1; motif: CAANATGGCGGC 0.0294347216512832 8220 132 74 0.560606060606061 0.00900243309002433
TF TF:M00739_1 Factor: E2F-4:DP-2; motif: TTTCSCGC; match class: 1 0.0296114922876371 1187 58 11 0.189655172413793 0.0092670598146588
TF TF:M11309 Factor: ATF-2; motif: NRTGACGTMANN 0.0296114922876371 6429 86 43 0.5 0.00668844299268938
TF TF:M06508 Factor: ZNF114; motif: GGCCGGSTAA 0.0298683429193395 68 112 4 0.0357142857142857 0.0588235294117647
TF TF:M00736_1 Factor: E2F-1:DP-1; motif: TTTCSCGC; match class: 1 0.0302146536963832 4639 139 50 0.359712230215827 0.0107781849536538
TF TF:M11151 Factor: MSGN1; motif: NRCCAWWTGKYN 0.030240247087334 353 39 5 0.128205128205128 0.0141643059490085
TF TF:M02069_1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 0.0306358204521937 1955 120 24 0.2 0.0122762148337596
TF TF:M07034 Factor: ATF-1; motif: NNNTGACGTNNN 0.0307066590475661 4248 86 32 0.372093023255814 0.00753295668549906
TF TF:M02064_1 Factor: c-ets-2; motif: ACCGGAWRTN; match class: 1 0.0307066590475661 4592 120 44 0.366666666666667 0.00958188153310104
TF TF:M02056_1 Factor: ELF4; motif: NCCGGAARTN; match class: 1 0.0307863842401795 1291 138 20 0.144927536231884 0.0154918667699458
TF TF:M07304 Factor: Pbx; motif: NTGATTGANN 0.0307863842401795 1571 32 9 0.28125 0.00572883513685551
TF TF:M10694_1 Factor: HOXA6; motif: NGYMATTANN; match class: 1 0.0307863842401795 702 97 11 0.11340206185567 0.0156695156695157
TF TF:M00017 Factor: ATF; motif: CNSTGACGTNNNYC 0.0311392464793663 7226 87 47 0.540229885057471 0.00650429006365901
TF TF:M01258 Factor: GABP; motif: CACTTCCGGNNN 0.0311392464793663 2838 120 31 0.258333333333333 0.01092318534179
TF TF:M10745 Factor: ipf1; motif: RTCATTAN 0.0311392464793663 2179 55 15 0.272727272727273 0.00688389169343736
TF TF:M11392_1 Factor: Erg; motif: NACCGGAARYN; match class: 1 0.0311392464793663 3233 120 34 0.283333333333333 0.010516548097742
TF TF:M10169_1 Factor: ZNF76; motif: RNNGCMTKCTGGGARNTGTAGT; match class: 1 0.0312340940062253 293 129 8 0.062015503875969 0.0273037542662116
TF TF:M11223 Factor: CREB1; motif: NRTGACGTCANN 0.0312400290162379 2810 81 23 0.283950617283951 0.00818505338078292
TF TF:M11447_1 Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 0.0313777040707422 2593 120 29 0.241666666666667 0.0111839568067875
TF TF:M02102 Factor: NRF-1; motif: YGCGCMTGCGC 0.0313777040707422 2020 138 27 0.195652173913043 0.0133663366336634
TF TF:M02067_1 Factor: ER71; motif: ACCGGAARYN; match class: 1 0.0313777040707422 1619 120 21 0.175 0.012970969734404
TF TF:M10783 Factor: hoxa9; motif: RTCGTWAANN 0.0313777040707422 1897 139 26 0.18705035971223 0.0137058513442277
TF TF:M10569 Factor: HB9; motif: NTCRTTAN 0.0313777040707422 3209 55 19 0.345454545454545 0.00592084761607978
TF TF:M11400_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.0320517581675639 4201 120 41 0.341666666666667 0.00975958105213045
TF TF:M00431_1 Factor: E2F-1; motif: TTTSGCGS; match class: 1 0.0332304389403258 2271 59 16 0.271186440677966 0.00704535446939674
TF TF:M03832 Factor: Net; motif: CACTTCCKGK 0.0332304389403258 929 138 16 0.115942028985507 0.0172228202368138
TF TF:M10765_1 Factor: Meox2; motif: NTCRTTAN; match class: 1 0.0332304389403258 206 18 3 0.166666666666667 0.0145631067961165
TF TF:M10733_1 Factor: HOXA2; motif: RTCRTTAN; match class: 1 0.0332304389403258 206 18 3 0.166666666666667 0.0145631067961165
TF TF:M00137 Factor: Oct-1; motif: NNNRTAATNANNN 0.0332304389403258 6851 44 26 0.590909090909091 0.00379506641366224
TF TF:M11382_1 Factor: ESE-1; motif: NWTRCGGAWGCN; match class: 1 0.0332304389403258 4112 138 45 0.326086956521739 0.010943579766537
TF TF:M11256 Factor: AIBZIP; motif: NGCCACGTCAYN 0.0332304389403258 1323 89 15 0.168539325842697 0.0113378684807256
TF TF:M07209 Factor: ELK4; motif: NCRCTTCCGGN 0.0332304389403258 1118 138 18 0.130434782608696 0.0161001788908766
TF TF:M09913 Factor: ER81; motif: NNCCGGAAGYG 0.0334381672345842 2871 120 31 0.258333333333333 0.0107976314872867
TF TF:M09887 Factor: CREB1; motif: NRRTGACGTMA 0.0335182107939787 5419 87 38 0.436781609195402 0.00701236390477948
TF TF:M01011_1 Factor: HNF-1; motif: NNNNGNTAAWNATTAACYNNN; match class: 1 0.0336386617051599 342 25 4 0.16 0.0116959064327485
TF TF:M10761 Factor: MOX1; motif: NTCRTTAN 0.0339978219722997 3158 65 21 0.323076923076923 0.00664977834072198
TF TF:M09608_1 Factor: Erg; motif: NNACCGGAARTSN; match class: 1 0.0341802623201288 2389 119 27 0.226890756302521 0.011301799916283
TF TF:M11223_1 Factor: CREB1; motif: NRTGACGTCANN; match class: 1 0.034487303132566 2678 81 22 0.271604938271605 0.0082150858849888
TF TF:M00095_1 Factor: CDP; motif: CCAATAATCGAT; match class: 1 0.034487303132566 2983 19 9 0.473684210526316 0.00301709688233322
TF TF:M01171 Factor: BCL6; motif: NKTTCTAGGW 0.034487303132566 1344 18 6 0.333333333333333 0.00446428571428571
TF TF:M10696_1 Factor: HOXA6; motif: NGYMATTANN; match class: 1 0.034487303132566 1223 97 15 0.154639175257732 0.0122649223221586
TF TF:M12275_1 Factor: YY1; motif: NGCCGCCATYTTGN; match class: 1 0.034487303132566 1600 115 20 0.173913043478261 0.0125
TF TF:M02097 Factor: LHX3; motif: ATTAAW 0.034487303132566 11840 46 38 0.826086956521739 0.00320945945945946
TF TF:M00114 Factor: Tax/CREB; motif: GGGGGTTGACGYANA 0.0345555818336156 6548 86 43 0.5 0.0065668906536347
TF TF:M11508 Factor: CDP; motif: NNATYGATYN 0.0346681836138636 3768 28 13 0.464285714285714 0.00345010615711253
TF TF:M00940 Factor: E2F-1; motif: NTTTCGCGCS 0.0346716155293033 7802 74 43 0.581081081081081 0.00551140733145347
TF TF:M03982_1 Factor: ETV4; motif: ACCGGAAGTN; match class: 1 0.0346716155293033 2009 120 24 0.2 0.0119462419113987
TF TF:M11419_1 Factor: ER81; motif: NNCCGGAWGYN; match class: 1 0.0346716155293033 1427 138 21 0.152173913043478 0.0147161878065872
TF TF:M07428 Factor: Six-3; motif: NWBTAATNYYWN 0.0347523202508635 3352 31 13 0.419354838709677 0.00387828162291169
TF TF:M04744_1 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 0.0352764368452031 4889 112 43 0.383928571428571 0.00879525465330333
TF TF:M11043 Factor: HMBOX1; motif: NCTAGTTAN 0.0352764368452031 597 26 5 0.192307692307692 0.00837520938023451
TF TF:M11247 Factor: Luman; motif: YGCCACGTCAYC 0.0354544604060857 174 86 5 0.0581395348837209 0.028735632183908
TF TF:M01654_1 Factor: DRI1; motif: AATTAA; match class: 1 0.0354544604060857 5831 36 20 0.555555555555556 0.0034299434059338
TF TF:M03546_1 Factor: Dlx-5; motif: AATTAN; match class: 1 0.0354544604060857 5831 36 20 0.555555555555556 0.0034299434059338
TF TF:M08785 Factor: Sox-6; motif: CACCGAACAAT 0.0354544604060857 1105 9 4 0.444444444444444 0.00361990950226244
TF TF:M10956_1 Factor: isx; motif: NTCRTTAA; match class: 1 0.0358638369485558 3336 35 14 0.4 0.00419664268585132
TF TF:M02054 Factor: ELF2; motif: CCCGGAARYN 0.0366169989638183 3066 124 33 0.266129032258065 0.0107632093933464
TF TF:M11225 Factor: CREM; motif: NNTGACGTCANN 0.0370162449947552 2710 81 22 0.271604938271605 0.00811808118081181
TF TF:M01185_1 Factor: BCL-6; motif: WRCTTTCKAGGRAT; match class: 1 0.0375397113366259 1192 44 9 0.204545454545455 0.0075503355704698
TF TF:M08803 Factor: CREM; motif: NNTGACGT 0.0385483060757899 1124 86 13 0.151162790697674 0.0115658362989324
TF TF:M01082 Factor: BRCA1:USF2; motif: KTNNGTTG 0.0385483060757899 7155 21 15 0.714285714285714 0.00209643605870021
TF TF:M10619 Factor: Dlx-2; motif: NYAATTAN 0.0386734623919633 937 103 13 0.12621359223301 0.0138740661686233
TF TF:M10704_1 Factor: HoxA5; motif: RTCATTAN; match class: 1 0.0386734623919633 1186 21 6 0.285714285714286 0.00505902192242833
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.0386734623919633 8947 85 53 0.623529411764706 0.00592377333184308
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 0.0386734623919633 5051 138 52 0.376811594202899 0.0102949910908731
TF TF:M10620 Factor: Dlx-2; motif: NYAATTAN 0.0386734623919633 937 103 13 0.12621359223301 0.0138740661686233
TF TF:M04303 Factor: Dlx-5; motif: NYAATTAN 0.0386734623919633 937 103 13 0.12621359223301 0.0138740661686233
TF TF:M10604 Factor: Dlx-7; motif: NYAATTAN 0.0386734623919633 937 103 13 0.12621359223301 0.0138740661686233
TF TF:M10602 Factor: Dlx-7; motif: NYAATTAN 0.0386734623919633 937 103 13 0.12621359223301 0.0138740661686233
TF TF:M03976_1 Factor: ERG; motif: ACCGGAWATCCGGT; match class: 1 0.0386734623919633 7781 139 73 0.525179856115108 0.0093818275285953
TF TF:M11285_1 Factor: Fra-1; motif: GRTGACGTCATC; match class: 1 0.0387543614687694 4589 86 33 0.383720930232558 0.00719110917411201
TF TF:M04399_1 Factor: MEOX2; motif: NSTAATTANN; match class: 1 0.0408475361302375 880 97 12 0.123711340206186 0.0136363636363636
TF TF:M04042 Factor: MYBL1; motif: ACCGTTAAACNG 0.0415727740503263 585 72 8 0.111111111111111 0.0136752136752137
TF TF:M10733 Factor: HOXA2; motif: RTCRTTAN 0.0427809491563291 2373 65 17 0.261538461538462 0.00716392751790982
TF TF:M10765 Factor: Meox2; motif: NTCRTTAN 0.0427809491563291 2373 65 17 0.261538461538462 0.00716392751790982
TF TF:M11427_1 Factor: PEA3; motif: NACCGGAAGTN; match class: 1 0.0427809491563291 4606 120 43 0.358333333333333 0.00933564915327833
TF TF:M00426_1 Factor: E2F; motif: TTTSGCGS; match class: 1 0.0427809491563291 5830 62 30 0.483870967741935 0.00514579759862779
TF TF:M11085_1 Factor: SREBP-2; motif: ATCACGTGAY; match class: 1 0.0427809491563291 1165 106 15 0.141509433962264 0.0128755364806867
TF TF:M03977_1 Factor: ETS1; motif: ACCGGAARYN; match class: 1 0.0427809491563291 4677 95 36 0.378947368421053 0.00769724182168056
TF TF:M02071_1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 0.0427809491563291 4465 120 42 0.35 0.00940649496080627
TF TF:M11307_1 Factor: ATF-2; motif: NNTGACGTMANN; match class: 1 0.0427809491563291 1946 29 9 0.310344827586207 0.00462487153134635
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0427809491563291 13270 139 110 0.79136690647482 0.00828937452901281
TF TF:M03990 Factor: GABPA; motif: ACCGGAAGTN 0.0439242186808175 5258 128 50 0.390625 0.00950931913275009
TF TF:M10729 Factor: HOXC-8; motif: RTCRTTAN 0.0441879368464484 3956 55 21 0.381818181818182 0.00530839231547017
TF TF:M10723 Factor: HOXD8; motif: RTCRTTAN 0.0446505885203 4249 55 22 0.4 0.00517768886796893
TF TF:M00736 Factor: E2F-1:DP-1; motif: TTTCSCGC 0.0446779241492956 10390 139 91 0.654676258992806 0.00875842155919153
TF TF:M08203_1 Factor: CDP:T-bet; motif: NTCACACNYYRATCRATM; match class: 1 0.0449037852088372 1482 18 6 0.333333333333333 0.00404858299595142
TF TF:M00179 Factor: ATF2; motif: VGTGACGTMACN 0.0449037852088372 6065 86 40 0.465116279069767 0.00659521846661171
TF TF:M10436_1 Factor: YY1; motif: CAANATGGCGGC; match class: 1 0.0449037852088372 2285 116 25 0.21551724137931 0.0109409190371991
TF TF:M07248 Factor: CREB1; motif: NNNNTGACGTNANNN 0.0452641817455446 4266 86 31 0.36046511627907 0.00726676043131739
TF TF:M00801_1 Factor: CREB; motif: CGTCAN; match class: 1 0.0462358126439436 647 83 9 0.108433734939759 0.0139103554868624
TF TF:M07140 Factor: Kaiso; motif: NTCTCGCGAGANYTN 0.0463522425495449 552 97 9 0.0927835051546392 0.016304347826087
TF TF:M10137 Factor: ZBP99; motif: NGGNGGGGGAGGGGN 0.0463522425495449 615 71 8 0.112676056338028 0.0130081300813008
TF TF:M04059_1 Factor: NRF-1; motif: YGCGCATGCGCN; match class: 1 0.0463522425495449 1033 133 16 0.120300751879699 0.0154888673765731
TF TF:M10650_1 Factor: HOX11L2; motif: NAATTGNNNNNNNNNNNNNCAATTN; match class: 1 0.0463522425495449 199 50 4 0.08 0.0201005025125628
TF TF:M05432_1 Factor: ZSCAN18; motif: TRRCGRCGNMCC; match class: 1 0.0463522425495449 818 107 12 0.11214953271028 0.0146699266503667
TF TF:M12057 Factor: ZBP99; motif: GCCCMTCCCCCR 0.0466705832871977 5225 117 46 0.393162393162393 0.00880382775119617
TF TF:M03544 Factor: CREB1; motif: NNNNACGTCANN 0.0486277716694729 4101 86 30 0.348837209302326 0.00731528895391368
TF TF:M09900_1 Factor: Elf-1; motif: NNANCCGGAAGTGS; match class: 1 0.0486579663240028 1158 120 16 0.133333333333333 0.0138169257340242
TF TF:M11529_1 Factor: E2F-2; motif: GCGCGCGCNCS; match class: 1 0.0486579663240028 14473 139 117 0.841726618705036 0.008084018517239
TF TF:M12310 Factor: ZNF597; motif: NGCCGCCATTTTGN 0.0486579663240028 437 58 6 0.103448275862069 0.0137299771167048
TF TF:M00023 Factor: HOXA5; motif: TGCNHNCWYCCYCATTAKTGNDCNMNHYCN 0.0486579663240028 3491 18 9 0.5 0.00257805786307648
TF TF:M03929_1 Factor: ZBTB7C; motif: NCGACCACCGNN; match class: 1 0.0486579663240028 303 34 4 0.117647058823529 0.0132013201320132
TF TF:M10018 Factor: NRF-1; motif: CNSTGCGCATGCGCNNS 0.0486579663240028 1816 138 24 0.173913043478261 0.013215859030837
TF TF:M02065_1 Factor: ER81; motif: RCCGGAARYN; match class: 1 0.0486579663240028 6749 120 57 0.475 0.00844569565861609
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 2.70422789096421e-09 105 18 8 0.444444444444444 0.0761904761904762
WP WP:WP623 Oxidative phosphorylation 0.000381607699568006 62 18 4 0.222222222222222 0.0645161290322581
WP WP:WP4922 Mitochondrial CIV Assembly 0.000882056789955237 35 15 3 0.2 0.0857142857142857
WP WP:WP4324 Mitochondrial complex I assembly model OXPHOS system 0.00283749613267517 56 16 3 0.1875 0.0535714285714286
WP WP:WP4396 Nonalcoholic fatty liver disease 0.00283749613267517 159 27 5 0.185185185185185 0.0314465408805031
WP WP:WP4656 Joubert Syndrome 0.0473547851152533 77 36 3 0.0833333333333333 0.038961038961039
WP WP:WP411 mRNA Processing 0.0494322590609058 133 68 5 0.0735294117647059 0.037593984962406

pEpi37 transcription factor target enrichment of top program genes

TF enrichment of pEpi37
Possible regulators of activation of pEpi37 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.