pEpi13 program activity among Epithelial cells

Activation of pEpi13
pEpi13 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi13 by different cell subtypes
pEpi13 gene program activation among cells of different subtypes (Epithelial cells).

pEpi13 top program genes

Top genes of pEpi13 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi13 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi13
pEpi13 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0061718 glucose catabolic process to pyruvate 1.85883749565283e-12 27 26 7 0.269230769230769 0.259259259259259
GO:BP GO:0061621 canonical glycolysis 1.85883749565283e-12 27 26 7 0.269230769230769 0.259259259259259
GO:BP GO:0006735 NADH regeneration 1.85883749565283e-12 27 26 7 0.269230769230769 0.259259259259259
GO:BP GO:0019674 NAD metabolic process 1.85883749565283e-12 52 26 8 0.307692307692308 0.153846153846154
GO:BP GO:0061620 glycolytic process through glucose-6-phosphate 1.98093856423646e-12 28 26 7 0.269230769230769 0.25
GO:BP GO:0061615 glycolytic process through fructose-6-phosphate 2.17403195326119e-12 29 26 7 0.269230769230769 0.241379310344828
GO:BP GO:0006757 ATP generation from ADP 7.70201385977236e-12 116 26 9 0.346153846153846 0.0775862068965517
GO:BP GO:0006007 glucose catabolic process 7.70201385977236e-12 36 26 7 0.269230769230769 0.194444444444444
GO:BP GO:0006096 glycolytic process 7.70201385977236e-12 115 26 9 0.346153846153846 0.0782608695652174
GO:BP GO:0006090 pyruvate metabolic process 9.2976591105378e-12 151 44 11 0.25 0.0728476821192053
GO:BP GO:0046031 ADP metabolic process 9.65972764319489e-12 123 26 9 0.346153846153846 0.0731707317073171
GO:BP GO:0009179 purine ribonucleoside diphosphate metabolic process 1.78190765032955e-11 136 26 9 0.346153846153846 0.0661764705882353
GO:BP GO:0009135 purine nucleoside diphosphate metabolic process 1.78190765032955e-11 136 26 9 0.346153846153846 0.0661764705882353
GO:BP GO:0006165 nucleoside diphosphate phosphorylation 1.78190765032955e-11 134 26 9 0.346153846153846 0.0671641791044776
GO:BP GO:0046939 nucleotide phosphorylation 1.78190765032955e-11 135 26 9 0.346153846153846 0.0666666666666667
GO:BP GO:0009185 ribonucleoside diphosphate metabolic process 2.03995547956244e-11 139 26 9 0.346153846153846 0.0647482014388489
GO:BP GO:0006734 NADH metabolic process 2.59055551363791e-11 46 26 7 0.269230769230769 0.152173913043478
GO:BP GO:0006094 gluconeogenesis 3.26763505082081e-11 89 26 8 0.307692307692308 0.0898876404494382
GO:BP GO:0019319 hexose biosynthetic process 4.06909322021964e-11 92 26 8 0.307692307692308 0.0869565217391304
GO:BP GO:0009132 nucleoside diphosphate metabolic process 5.25464492033588e-11 158 26 9 0.346153846153846 0.0569620253164557
GO:BP GO:0046364 monosaccharide biosynthetic process 6.19116757526402e-11 98 26 8 0.307692307692308 0.0816326530612245
GO:BP GO:0019320 hexose catabolic process 9.78834047617405e-11 57 26 7 0.269230769230769 0.12280701754386
GO:BP GO:0046365 monosaccharide catabolic process 1.94852440156315e-10 63 26 7 0.269230769230769 0.111111111111111
GO:BP GO:0016052 carbohydrate catabolic process 3.38303797289907e-10 198 26 9 0.346153846153846 0.0454545454545455
GO:BP GO:0019752 carboxylic acid metabolic process 5.00512456661366e-10 1024 44 18 0.409090909090909 0.017578125
GO:BP GO:0043436 oxoacid metabolic process 8.163013191346e-10 1057 44 18 0.409090909090909 0.0170293282876064
GO:BP GO:0046034 ATP metabolic process 1.26285243143241e-09 314 28 10 0.357142857142857 0.0318471337579618
GO:BP GO:0006082 organic acid metabolic process 1.26285243143241e-09 1090 44 18 0.409090909090909 0.0165137614678899
GO:BP GO:0019318 hexose metabolic process 1.55919355885402e-09 253 46 11 0.239130434782609 0.0434782608695652
GO:BP GO:0006091 generation of precursor metabolites and energy 1.92746201762381e-09 538 46 14 0.304347826086957 0.0260223048327138
GO:BP GO:0072521 purine-containing compound metabolic process 2.61443693085709e-09 473 28 11 0.392857142857143 0.0232558139534884
GO:BP GO:0005996 monosaccharide metabolic process 3.59763550302453e-09 276 46 11 0.239130434782609 0.0398550724637681
GO:BP GO:0006006 glucose metabolic process 5.23245720551081e-09 211 46 10 0.217391304347826 0.0473933649289099
GO:BP GO:0016051 carbohydrate biosynthetic process 5.83470061112585e-09 214 46 10 0.217391304347826 0.0467289719626168
GO:BP GO:0009150 purine ribonucleotide metabolic process 8.8647433210391e-09 414 44 12 0.272727272727273 0.0289855072463768
GO:BP GO:0009259 ribonucleotide metabolic process 1.36670615605189e-08 431 44 12 0.272727272727273 0.0278422273781903
GO:BP GO:0005975 carbohydrate metabolic process 1.38623531870506e-08 635 46 14 0.304347826086957 0.0220472440944882
GO:BP GO:0044281 small molecule metabolic process 1.49516904097786e-08 1921 47 22 0.468085106382979 0.0114523685580427
GO:BP GO:0055086 nucleobase-containing small molecule metabolic process 1.5817918806181e-08 629 47 14 0.297872340425532 0.0222575516693164
GO:BP GO:0019693 ribose phosphate metabolic process 1.5817918806181e-08 441 27 10 0.37037037037037 0.0226757369614512
GO:BP GO:0006163 purine nucleotide metabolic process 1.87785662957044e-08 450 27 10 0.37037037037037 0.0222222222222222
GO:BP GO:0032787 monocarboxylic acid metabolic process 1.94500282092458e-08 658 20 10 0.5 0.0151975683890578
GO:BP GO:0044283 small molecule biosynthetic process 2.95878260553366e-08 704 31 12 0.387096774193548 0.0170454545454545
GO:BP GO:0009117 nucleotide metabolic process 1.09358840567045e-07 544 27 10 0.37037037037037 0.0183823529411765
GO:BP GO:0006753 nucleoside phosphate metabolic process 1.29592251619856e-07 555 27 10 0.37037037037037 0.018018018018018
GO:BP GO:0036293 response to decreased oxygen levels 2.08050535920337e-07 382 21 8 0.380952380952381 0.0209424083769634
GO:BP GO:0070482 response to oxygen levels 3.40669247909404e-07 408 21 8 0.380952380952381 0.0196078431372549
GO:BP GO:0036294 cellular response to decreased oxygen levels 8.26093471688523e-07 222 40 8 0.2 0.036036036036036
GO:BP GO:0044282 small molecule catabolic process 8.26093471688523e-07 439 30 9 0.3 0.020501138952164
GO:BP GO:0071453 cellular response to oxygen levels 1.48235371653905e-06 240 40 8 0.2 0.0333333333333333
GO:BP GO:0001666 response to hypoxia 2.64036042372646e-06 367 40 9 0.225 0.0245231607629428
GO:BP GO:0019637 organophosphate metabolic process 3.76525027671778e-06 1041 27 11 0.407407407407407 0.010566762728146
GO:BP GO:0071456 cellular response to hypoxia 1.13518488439823e-05 212 40 7 0.175 0.0330188679245283
GO:BP GO:0043067 regulation of programmed cell death 3.38126911075731e-05 1582 19 10 0.526315789473684 0.00632111251580278
GO:BP GO:0012501 programmed cell death 5.64032328159743e-05 2143 19 11 0.578947368421053 0.00513299113392441
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 5.67744811796331e-05 294 14 5 0.357142857142857 0.0170068027210884
GO:BP GO:0010941 regulation of cell death 6.92620347989777e-05 1720 19 10 0.526315789473684 0.00581395348837209
GO:BP GO:1901135 carbohydrate derivative metabolic process 8.68612031702507e-05 1145 27 10 0.37037037037037 0.00873362445414847
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 9.07932442352162e-05 167 12 4 0.333333333333333 0.0239520958083832
GO:BP GO:0060548 negative regulation of cell death 9.44654075052152e-05 1038 43 12 0.27906976744186 0.0115606936416185
GO:BP GO:0008219 cell death 9.97434522409258e-05 2292 19 11 0.578947368421053 0.00479930191972077
GO:BP GO:1903580 positive regulation of ATP metabolic process 9.97725790784241e-05 44 13 3 0.230769230769231 0.0681818181818182
GO:BP GO:0009628 response to abiotic stimulus 0.000130914515577442 1261 21 9 0.428571428571429 0.00713719270420301
GO:BP GO:0006000 fructose metabolic process 0.000148603706050657 15 44 3 0.0681818181818182 0.2
GO:BP GO:0002082 regulation of oxidative phosphorylation 0.000206202820335624 26 28 3 0.107142857142857 0.115384615384615
GO:BP GO:0043069 negative regulation of programmed cell death 0.000214783504737221 943 43 11 0.255813953488372 0.0116648992576882
GO:BP GO:0006915 apoptotic process 0.000215956842680236 1990 19 10 0.526315789473684 0.0050251256281407
GO:BP GO:1903578 regulation of ATP metabolic process 0.000231566737525757 119 44 5 0.113636363636364 0.0420168067226891
GO:BP GO:0042981 regulation of apoptotic process 0.000231566737525757 1549 19 9 0.473684210526316 0.00581020012911556
GO:BP GO:0006413 translational initiation 0.000416957906438418 201 15 4 0.266666666666667 0.0199004975124378
GO:BP GO:0043603 cellular amide metabolic process 0.000478074958855998 1241 43 12 0.27906976744186 0.0096696212731668
GO:BP GO:0097190 apoptotic signaling pathway 0.000537159166188619 600 19 6 0.315789473684211 0.01
GO:BP GO:1901575 organic substance catabolic process 0.000589487883974446 2267 30 13 0.433333333333333 0.00573445081605646
GO:BP GO:0006446 regulation of translational initiation 0.000631103349927234 80 14 3 0.214285714285714 0.0375
GO:BP GO:1901564 organonitrogen compound metabolic process 0.000738239154339281 6792 44 30 0.681818181818182 0.00441696113074205
GO:BP GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 0.000738239154339281 100 12 3 0.25 0.03
GO:BP GO:0009056 catabolic process 0.000882342645209202 2744 30 14 0.466666666666667 0.00510204081632653
GO:BP GO:0043066 negative regulation of apoptotic process 0.000934873295647223 921 43 10 0.232558139534884 0.01085776330076
GO:BP GO:0043467 regulation of generation of precursor metabolites and energy 0.00116567183283326 164 46 5 0.108695652173913 0.0304878048780488
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.00137016599660599 363 12 4 0.333333333333333 0.0110192837465565
GO:BP GO:0006518 peptide metabolic process 0.00137298768815741 955 15 6 0.4 0.00628272251308901
GO:BP GO:0051402 neuron apoptotic process 0.00141628640694323 250 17 4 0.235294117647059 0.016
GO:BP GO:0051289 protein homotetramerization 0.00166039126926153 56 28 3 0.107142857142857 0.0535714285714286
GO:BP GO:0044262 cellular carbohydrate metabolic process 0.00182851272256918 296 46 6 0.130434782608696 0.0202702702702703
GO:BP GO:0006950 response to stress 0.00201167965806824 4170 23 14 0.608695652173913 0.00335731414868106
GO:BP GO:0051260 protein homooligomerization 0.00283410897654303 180 28 4 0.142857142857143 0.0222222222222222
GO:BP GO:0016310 phosphorylation 0.00332237391234829 2138 28 11 0.392857142857143 0.00514499532273152
GO:BP GO:1900542 regulation of purine nucleotide metabolic process 0.00339746748554094 119 44 4 0.0909090909090909 0.0336134453781513
GO:BP GO:0006140 regulation of nucleotide metabolic process 0.00354731223458302 121 44 4 0.0909090909090909 0.0330578512396694
GO:BP GO:0033554 cellular response to stress 0.00401271714703086 2111 43 14 0.325581395348837 0.00663192799621033
GO:BP GO:0006412 translation 0.00452461469015162 764 15 5 0.333333333333333 0.00654450261780105
GO:BP GO:0043604 amide biosynthetic process 0.00454165516296132 932 43 9 0.209302325581395 0.00965665236051502
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.00459979806995063 3087 28 13 0.464285714285714 0.00421120829284095
GO:BP GO:0051262 protein tetramerization 0.00459979806995063 84 28 3 0.107142857142857 0.0357142857142857
GO:BP GO:0070997 neuron death 0.00486536081970872 365 17 4 0.235294117647059 0.010958904109589
GO:BP GO:0006793 phosphorus metabolic process 0.00489449061345464 3114 28 13 0.464285714285714 0.00417469492614001
GO:BP GO:0043043 peptide biosynthetic process 0.00494313383307311 790 15 5 0.333333333333333 0.00632911392405063
GO:BP GO:0006417 regulation of translation 0.00514908650716157 462 14 4 0.285714285714286 0.00865800865800866
GO:BP GO:0070887 cellular response to chemical stimulus 0.00569822171339728 3393 43 18 0.418604651162791 0.00530503978779841
GO:BP GO:0051259 protein complex oligomerization 0.00645440913193735 234 28 4 0.142857142857143 0.0170940170940171
GO:BP GO:2001234 negative regulation of apoptotic signaling pathway 0.00646912126746342 236 12 3 0.25 0.0127118644067797
GO:BP GO:0042221 response to chemical 0.00661070850575871 4781 43 22 0.511627906976744 0.00460154779334867
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.00765706534232651 1853 30 10 0.333333333333333 0.00539665407447383
GO:BP GO:0009058 biosynthetic process 0.00790187258685284 6340 43 26 0.604651162790698 0.00410094637223975
GO:BP GO:0016236 macroautophagy 0.00812514500372757 312 23 4 0.173913043478261 0.0128205128205128
GO:BP GO:0016241 regulation of macroautophagy 0.00812514500372757 161 19 3 0.157894736842105 0.0186335403726708
GO:BP GO:0034248 regulation of cellular amide metabolic process 0.00812514500372757 535 14 4 0.285714285714286 0.00747663551401869
GO:BP GO:0006979 response to oxidative stress 0.00869160972467787 466 42 6 0.142857142857143 0.0128755364806867
GO:BP GO:0043523 regulation of neuron apoptotic process 0.00885246304473079 216 34 4 0.117647058823529 0.0185185185185185
GO:BP GO:0009636 response to toxic substance 0.0097713263721035 243 14 3 0.214285714285714 0.0123456790123457
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0129540363186539 2541 17 8 0.470588235294118 0.00314836678473042
GO:BP GO:0048519 negative regulation of biological process 0.0131114516584592 5757 19 13 0.684210526315789 0.00225812054889699
GO:BP GO:0072522 purine-containing compound biosynthetic process 0.0138924771396224 213 40 4 0.1 0.0187793427230047
GO:BP GO:1901605 alpha-amino acid metabolic process 0.0138924771396224 198 43 4 0.0930232558139535 0.0202020202020202
GO:BP GO:1901576 organic substance biosynthetic process 0.0138924771396224 6248 18 13 0.722222222222222 0.00208066581306018
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0141287642644446 745 6 3 0.5 0.00402684563758389
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.0151084468194796 6563 50 29 0.58 0.00441871095535578
GO:BP GO:0007033 vacuole organization 0.0161287903028378 181 23 3 0.130434782608696 0.0165745856353591
GO:BP GO:0009605 response to external stimulus 0.0161768970270363 2944 19 9 0.473684210526316 0.0030570652173913
GO:BP GO:0072331 signal transduction by p53 class mediator 0.0161910968255106 268 16 3 0.1875 0.0111940298507463
GO:BP GO:0010628 positive regulation of gene expression 0.0164278500767074 1160 21 6 0.285714285714286 0.00517241379310345
GO:BP GO:0006119 oxidative phosphorylation 0.0164278500767074 151 28 3 0.107142857142857 0.0198675496688742
GO:BP GO:0001819 positive regulation of cytokine production 0.016594767240429 452 21 4 0.19047619047619 0.00884955752212389
GO:BP GO:0051246 regulation of protein metabolic process 0.0167789708207814 2704 17 8 0.470588235294118 0.0029585798816568
GO:BP GO:0010035 response to inorganic substance 0.0170428205757463 575 17 4 0.235294117647059 0.00695652173913044
GO:BP GO:0080135 regulation of cellular response to stress 0.0174603325605382 725 14 4 0.285714285714286 0.00551724137931034
GO:BP GO:0120161 regulation of cold-induced thermogenesis 0.0174603325605382 144 31 3 0.0967741935483871 0.0208333333333333
GO:BP GO:0106106 cold-induced thermogenesis 0.0174603325605382 144 31 3 0.0967741935483871 0.0208333333333333
GO:BP GO:0006109 regulation of carbohydrate metabolic process 0.0175239050975473 210 46 4 0.0869565217391304 0.019047619047619
GO:BP GO:1990845 adaptive thermogenesis 0.019154281016167 155 31 3 0.0967741935483871 0.0193548387096774
GO:BP GO:0002274 myeloid leukocyte activation 0.019154281016167 667 26 5 0.192307692307692 0.00749625187406297
GO:BP GO:1901214 regulation of neuron death 0.02330859816919 323 34 4 0.117647058823529 0.0123839009287926
GO:BP GO:0065003 protein-containing complex assembly 0.0235371603774586 1680 28 8 0.285714285714286 0.00476190476190476
GO:BP GO:0043065 positive regulation of apoptotic process 0.0237925079424926 604 19 4 0.210526315789474 0.00662251655629139
GO:BP GO:0001659 temperature homeostasis 0.0239229619033679 174 31 3 0.0967741935483871 0.0172413793103448
GO:BP GO:0030162 regulation of proteolysis 0.0246206703230477 752 8 3 0.375 0.00398936170212766
GO:BP GO:0080134 regulation of response to stress 0.0248824263646093 1443 14 5 0.357142857142857 0.00346500346500346
GO:BP GO:0043068 positive regulation of programmed cell death 0.0251403946902185 621 19 4 0.210526315789474 0.00644122383252818
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.0272753349324147 896 14 4 0.285714285714286 0.00446428571428571
GO:BP GO:0015698 inorganic anion transport 0.0279353125004809 169 35 3 0.0857142857142857 0.0177514792899408
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.0288780075978213 1001 13 4 0.307692307692308 0.003996003996004
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.0288780075978213 1001 13 4 0.307692307692308 0.003996003996004
GO:BP GO:0061919 process utilizing autophagic mechanism 0.0288780075978213 543 23 4 0.173913043478261 0.00736648250460405
GO:BP GO:0006914 autophagy 0.0288780075978213 543 23 4 0.173913043478261 0.00736648250460405
GO:BP GO:0043312 neutrophil degranulation 0.0295375313369269 482 26 4 0.153846153846154 0.00829875518672199
GO:BP GO:0010038 response to metal ion 0.0296236528158353 371 17 3 0.176470588235294 0.00808625336927224
GO:BP GO:0002283 neutrophil activation involved in immune response 0.0297346496139259 485 26 4 0.153846153846154 0.00824742268041237
GO:BP GO:0017148 negative regulation of translation 0.0299484427314593 223 28 3 0.107142857142857 0.0134529147982063
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0301447881273733 549 12 3 0.25 0.00546448087431694
GO:BP GO:0010506 regulation of autophagy 0.0301447881273733 336 19 3 0.157894736842105 0.00892857142857143
GO:BP GO:0010942 positive regulation of cell death 0.0301447881273733 684 19 4 0.210526315789474 0.00584795321637427
GO:BP GO:0032680 regulation of tumor necrosis factor production 0.0307318037835986 163 39 3 0.0769230769230769 0.0184049079754601
GO:BP GO:0002446 neutrophil mediated immunity 0.0307791527938419 497 26 4 0.153846153846154 0.00804828973843058
GO:BP GO:0032640 tumor necrosis factor production 0.0308490798264435 165 39 3 0.0769230769230769 0.0181818181818182
GO:BP GO:0042119 neutrophil activation 0.0308490798264435 498 26 4 0.153846153846154 0.00803212851405622
GO:BP GO:0062012 regulation of small molecule metabolic process 0.0308490798264435 447 46 5 0.108695652173913 0.0111856823266219
GO:BP GO:0036230 granulocyte activation 0.0309407855062258 504 26 4 0.153846153846154 0.00793650793650794
GO:BP GO:0010629 negative regulation of gene expression 0.0309407855062258 1460 42 9 0.214285714285714 0.00616438356164384
GO:BP GO:0031667 response to nutrient levels 0.0309407855062258 482 43 5 0.116279069767442 0.0103734439834025
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.0310690463699392 167 39 3 0.0769230769230769 0.0179640718562874
GO:BP GO:0006575 cellular modified amino acid metabolic process 0.0311592883781416 199 33 3 0.0909090909090909 0.0150753768844221
GO:BP GO:0009893 positive regulation of metabolic process 0.0311592883781416 3783 21 10 0.476190476190476 0.00264340470526038
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.0316720547985744 170 39 3 0.0769230769230769 0.0176470588235294
GO:BP GO:0051239 regulation of multicellular organismal process 0.0319517111012794 2861 31 11 0.354838709677419 0.00384480950716533
GO:BP GO:0062013 positive regulation of small molecule metabolic process 0.0321995240000086 145 46 3 0.0652173913043478 0.0206896551724138
GO:BP GO:0010675 regulation of cellular carbohydrate metabolic process 0.0338197455712207 149 46 3 0.0652173913043478 0.0201342281879195
GO:BP GO:0009267 cellular response to starvation 0.0338980463079204 160 43 3 0.0697674418604651 0.01875
GO:BP GO:0044249 cellular biosynthetic process 0.0338980463079204 6154 50 26 0.52 0.00422489437764056
GO:BP GO:0048523 negative regulation of cellular process 0.0344070294135686 5139 19 11 0.578947368421053 0.00214049425958358
GO:BP GO:0043299 leukocyte degranulation 0.0346140044903277 535 26 4 0.153846153846154 0.00747663551401869
GO:BP GO:0034249 negative regulation of cellular amide metabolic process 0.0347923478757243 253 28 3 0.107142857142857 0.0118577075098814
GO:BP GO:0006996 organelle organization 0.0349541143568202 4104 23 11 0.478260869565217 0.00268031189083821
GO:BP GO:0009991 response to extracellular stimulus 0.0352859498162142 512 43 5 0.116279069767442 0.009765625
GO:BP GO:0001817 regulation of cytokine production 0.0352886867709253 806 39 6 0.153846153846154 0.00744416873449132
GO:BP GO:0009152 purine ribonucleotide biosynthetic process 0.0354194389050573 179 40 3 0.075 0.0167597765363128
GO:BP GO:0014070 response to organic cyclic compound 0.0354194389050573 967 43 7 0.162790697674419 0.00723888314374354
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0354194389050573 547 26 4 0.153846153846154 0.00731261425959781
GO:BP GO:1901215 negative regulation of neuron death 0.0357044352253531 213 34 3 0.0882352941176471 0.0140845070422535
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0360923802983653 551 26 4 0.153846153846154 0.00725952813067151
GO:BP GO:0046394 carboxylic acid biosynthetic process 0.0367115899699954 330 43 4 0.0930232558139535 0.0121212121212121
GO:BP GO:0046483 heterocycle metabolic process 0.0375451986614253 5904 50 25 0.5 0.00423441734417344
GO:BP GO:0043933 protein-containing complex subunit organization 0.0378557892219086 1963 28 8 0.285714285714286 0.00407539480387163
GO:BP GO:0006954 inflammatory response 0.0378557892219086 794 10 3 0.3 0.00377833753148615
GO:BP GO:0016053 organic acid biosynthetic process 0.0385212259428509 338 43 4 0.0930232558139535 0.0118343195266272
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.0386791565418229 5746 20 12 0.6 0.00208840932822833
GO:BP GO:0009892 negative regulation of metabolic process 0.0386791565418229 3479 17 8 0.470588235294118 0.00229951135383731
GO:BP GO:0006520 cellular amino acid metabolic process 0.0388322316049881 341 43 4 0.0930232558139535 0.0117302052785924
GO:BP GO:0009260 ribonucleotide biosynthetic process 0.0392529572278074 192 40 3 0.075 0.015625
GO:BP GO:0001816 cytokine production 0.0393667266466525 844 39 6 0.153846153846154 0.00710900473933649
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.0395600786587234 5956 50 25 0.5 0.0041974479516454
GO:BP GO:0046390 ribose phosphate biosynthetic process 0.04133719273517 199 40 3 0.075 0.0150753768844221
GO:BP GO:0044237 cellular metabolic process 0.0417339725752801 10871 48 37 0.770833333333333 0.00340355073130347
GO:BP GO:0006164 purine nucleotide biosynthetic process 0.0419478423797687 202 40 3 0.075 0.0148514851485149
GO:BP GO:0022607 cellular component assembly 0.0453172487715769 3010 28 10 0.357142857142857 0.00332225913621262
GO:BP GO:0042594 response to starvation 0.0470467554288381 202 43 3 0.0697674418604651 0.0148514851485149
GO:BP GO:0006952 defense response 0.0491329936831234 1818 10 4 0.4 0.0022002200220022
GO:CC GO:1903561 extracellular vesicle 0.000230426355627227 2261 34 15 0.441176470588235 0.00663423264042459
GO:CC GO:0043230 extracellular organelle 0.000230426355627227 2263 34 15 0.441176470588235 0.0066283694211224
GO:CC GO:0070062 extracellular exosome 0.000230426355627227 2176 34 15 0.441176470588235 0.00689338235294118
GO:CC GO:0005829 cytosol 0.000832915905205159 5303 28 19 0.678571428571429 0.00358287761644352
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.00118396149977558 124 26 4 0.153846153846154 0.032258064516129
GO:CC GO:0005615 extracellular space 0.0017478083604882 3594 37 18 0.486486486486487 0.00500834724540901
GO:CC GO:0031982 vesicle 0.00245784943687176 4055 21 13 0.619047619047619 0.0032059186189889
GO:CC GO:0005737 cytoplasm 0.00317254513911362 11911 40 36 0.9 0.00302241625388297
GO:CC GO:0101002 ficolin-1-rich granule 0.00317254513911362 184 26 4 0.153846153846154 0.0217391304347826
GO:CC GO:0005576 extracellular region 0.0057215330288798 4567 21 13 0.619047619047619 0.00284650755419312
GO:CC GO:0034774 secretory granule lumen 0.0134231684785819 320 26 4 0.153846153846154 0.0125
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0134231684785819 324 26 4 0.153846153846154 0.0123456790123457
GO:CC GO:0031983 vesicle lumen 0.0134231684785819 326 26 4 0.153846153846154 0.0122699386503067
GO:CC GO:0030141 secretory granule 0.0134231684785819 851 26 6 0.230769230769231 0.00705052878965922
GO:CC GO:0005634 nucleus 0.0134231684785819 7592 21 16 0.761904761904762 0.00210748155953635
GO:CC GO:0030017 sarcomere 0.0170444037345224 208 20 3 0.15 0.0144230769230769
GO:CC GO:0030016 myofibril 0.0184783686881576 231 20 3 0.15 0.012987012987013
GO:CC GO:0005739 mitochondrion 0.0184783686881576 1673 33 9 0.272727272727273 0.00537955768081291
GO:CC GO:0043292 contractile fiber 0.0188329411700347 240 20 3 0.15 0.0125
GO:CC GO:0099503 secretory vesicle 0.0193887068976981 1020 26 6 0.230769230769231 0.00588235294117647
GO:CC GO:0048471 perinuclear region of cytoplasm 0.0226273395756974 735 16 4 0.25 0.0054421768707483
GO:CC GO:0005759 mitochondrial matrix 0.0238983083356042 479 40 5 0.125 0.0104384133611691
GO:CC GO:0031974 membrane-enclosed lumen 0.0251628420071326 5565 42 21 0.5 0.00377358490566038
GO:CC GO:0043233 organelle lumen 0.0251628420071326 5565 42 21 0.5 0.00377358490566038
GO:CC GO:0005856 cytoskeleton 0.0251628420071326 2332 32 10 0.3125 0.00428816466552316
GO:CC GO:0031967 organelle envelope 0.0429757388709913 1237 28 6 0.214285714285714 0.00485044462409054
GO:CC GO:0031975 envelope 0.0429757388709913 1237 28 6 0.214285714285714 0.00485044462409054
GO:CC GO:0005622 intracellular anatomical structure 0.0465178261158615 14790 35 33 0.942857142857143 0.00223123732251521
GO:MF GO:0016832 aldehyde-lyase activity 0.000122629520281453 10 28 3 0.107142857142857 0.3
GO:MF GO:0045296 cadherin binding 0.000164415420960004 333 20 6 0.3 0.018018018018018
GO:MF GO:0016829 lyase activity 0.000789827048162607 203 28 5 0.178571428571429 0.0246305418719212
GO:MF GO:0050839 cell adhesion molecule binding 0.000808594420966383 546 20 6 0.3 0.010989010989011
GO:MF GO:0016860 intramolecular oxidoreductase activity 0.000808594420966383 53 17 3 0.176470588235294 0.0566037735849057
GO:MF GO:0016491 oxidoreductase activity 0.00170772053839413 771 33 8 0.242424242424242 0.0103761348897536
GO:MF GO:0016830 carbon-carbon lyase activity 0.00174918748244394 50 28 3 0.107142857142857 0.06
GO:MF GO:0048029 monosaccharide binding 0.00277770072562379 71 25 3 0.12 0.0422535211267606
GO:MF GO:0042802 identical protein binding 0.00537021405263669 2067 10 6 0.6 0.00290275761973875
GO:MF GO:0016853 isomerase activity 0.00624677496985448 169 38 4 0.105263157894737 0.0236686390532544
GO:MF GO:0030246 carbohydrate binding 0.00828078310511053 275 46 5 0.108695652173913 0.0181818181818182
GO:MF GO:0090079 translation regulator activity, nucleic acid binding 0.00986122129644986 123 28 3 0.107142857142857 0.024390243902439
GO:MF GO:0045182 translation regulator activity 0.0141090169201126 155 28 3 0.107142857142857 0.0193548387096774
GO:MF GO:0019842 vitamin binding 0.0148256855230446 149 32 3 0.09375 0.0201342281879195
GO:MF GO:0003824 catalytic activity 0.01760149610793 5896 34 19 0.558823529411765 0.0032225237449118
GO:MF GO:0036094 small molecule binding 0.0213990559194111 2506 44 13 0.295454545454545 0.00518754988028731
GO:MF GO:0015631 tubulin binding 0.0325349391733651 376 20 3 0.15 0.00797872340425532
GO:MF GO:0019899 enzyme binding 0.0345398618995428 2074 17 6 0.352941176470588 0.00289296046287367
GO:MF GO:1901363 heterocyclic compound binding 0.0350874396500844 6228 15 10 0.666666666666667 0.00160565189466924
GO:MF GO:0097159 organic cyclic compound binding 0.0369371964264171 6309 15 10 0.666666666666667 0.00158503724837534
GO:MF GO:0042803 protein homodimerization activity 0.0387602481073182 676 37 5 0.135135135135135 0.00739644970414201
GO:MF GO:0003712 transcription coregulator activity 0.0395359636848648 506 50 5 0.1 0.00988142292490119
GO:MF GO:0008092 cytoskeletal protein binding 0.0395359636848648 996 26 5 0.192307692307692 0.00502008032128514
GO:MF GO:1901265 nucleoside phosphate binding 0.0396215603673542 2172 13 5 0.384615384615385 0.00230202578268877
GO:MF GO:0000166 nucleotide binding 0.0396215603673542 2171 13 5 0.384615384615385 0.00230308613542146
GO:MF GO:0046983 protein dimerization activity 0.0495263100723406 1069 37 6 0.162162162162162 0.00561272217025257
HP HP:0001082 Cholecystitis 0.0448728417685719 20 20 3 0.15 0.15
HP HP:0012438 Abnormal gallbladder physiology 0.0448728417685719 20 20 3 0.15 0.15
KEGG KEGG:00010 Glycolysis / Gluconeogenesis 2.07156760429038e-09 67 26 8 0.307692307692308 0.119402985074627
KEGG KEGG:01230 Biosynthesis of amino acids 7.08079382659676e-09 75 43 9 0.209302325581395 0.12
KEGG KEGG:01200 Carbon metabolism 1.18318276944561e-07 116 28 8 0.285714285714286 0.0689655172413793
KEGG KEGG:04066 HIF-1 signaling pathway 2.19382825179606e-05 109 40 7 0.175 0.0642201834862385
KEGG KEGG:00051 Fructose and mannose metabolism 0.00055073183310413 33 44 4 0.0909090909090909 0.121212121212121
KEGG KEGG:00030 Pentose phosphate pathway 0.00184777968786008 30 26 3 0.115384615384615 0.1
KEGG KEGG:01100 Metabolic pathways 0.00193145156562249 1490 34 16 0.470588235294118 0.010738255033557
MIRNA MIRNA:hsa-miR-423-5p hsa-miR-423-5p 0.0174039134818575 342 26 6 0.230769230769231 0.0175438596491228
MIRNA MIRNA:hsa-miR-6805-5p hsa-miR-6805-5p 0.0174039134818575 102 28 4 0.142857142857143 0.0392156862745098
MIRNA MIRNA:hsa-miR-331-3p hsa-miR-331-3p 0.0208231911377474 403 17 5 0.294117647058824 0.0124069478908189
MIRNA MIRNA:hsa-miR-5683 hsa-miR-5683 0.0220197646269003 97 37 4 0.108108108108108 0.0412371134020619
MIRNA MIRNA:hsa-miR-615-3p hsa-miR-615-3p 0.0264854442820513 891 28 8 0.285714285714286 0.00897867564534231
MIRNA MIRNA:hsa-miR-320a hsa-miR-320a 0.0392608473853731 584 25 6 0.24 0.0102739726027397
MIRNA MIRNA:hsa-miR-7114-5p hsa-miR-7114-5p 0.0392608473853731 73 28 3 0.107142857142857 0.0410958904109589
MIRNA MIRNA:hsa-miR-4488 hsa-miR-4488 0.0444073121074398 105 23 3 0.130434782608696 0.0285714285714286
MIRNA MIRNA:hsa-miR-1237-5p hsa-miR-1237-5p 0.0444073121074398 107 23 3 0.130434782608696 0.0280373831775701
MIRNA MIRNA:hsa-miR-4697-5p hsa-miR-4697-5p 0.0444073121074398 104 23 3 0.130434782608696 0.0288461538461538
REAC REAC:R-HSA-70263 Gluconeogenesis 1.09117708508826e-10 32 26 7 0.269230769230769 0.21875
REAC REAC:R-HSA-70171 Glycolysis 1.33367417104612e-08 67 26 7 0.269230769230769 0.104477611940299
REAC REAC:R-HSA-70326 Glucose metabolism 4.90435281444181e-08 85 26 7 0.269230769230769 0.0823529411764706
REAC REAC:R-HSA-71387 Metabolism of carbohydrates 6.16983851847601e-05 285 44 9 0.204545454545455 0.0315789473684211
REAC REAC:R-HSA-1430728 Metabolism 0.00198717839637775 2070 47 21 0.446808510638298 0.0101449275362319
TF TF:M07043 Factor: HIF-1alpha; motif: NNACGTGNN 5.03191105697876e-06 1439 23 13 0.565217391304348 0.00903405142460042
TF TF:M09773 Factor: HIF1A; motif: NNACGTGCNN 0.000194526032792998 2413 38 18 0.473684210526316 0.00745959386655615
TF TF:M00797 Factor: HIF1; motif: GNNKACGTGCGGNN 0.000194526032792998 3576 23 16 0.695652173913043 0.00447427293064877
TF TF:M02378 Factor: HIF1A:ARNT; motif: VNACGTGN 0.000254257787372481 856 51 13 0.254901960784314 0.0151869158878505
TF TF:M09944 Factor: HIF-1alpha; motif: GNACGTGM 0.00033106450646492 5581 40 27 0.675 0.0048378426805232
TF TF:M09944_1 Factor: HIF-1alpha; motif: GNACGTGM; match class: 1 0.000364896981160367 1384 53 16 0.30188679245283 0.0115606936416185
TF TF:M09906 Factor: HIF2A; motif: NTACGTGMN 0.000379718714754232 933 51 13 0.254901960784314 0.0139335476956056
TF TF:M02012 Factor: HIF-1alpha; motif: NCACGT 0.000379718714754232 6648 38 28 0.736842105263158 0.00421179302045728
TF TF:M07043_1 Factor: HIF-1alpha; motif: NNACGTGNN; match class: 1 0.000711331744536433 120 31 5 0.161290322580645 0.0416666666666667
TF TF:M01249 Factor: HIF2alpha; motif: NNACGTGCNN 0.00194928814627088 1509 51 15 0.294117647058824 0.0099403578528827
TF TF:M04950_1 Factor: Egr-1; motif: NGCGTGCGY; match class: 1 0.00194928814627088 5551 37 24 0.648648648648649 0.00432354530715186
TF TF:M00466_1 Factor: HIF1; motif: NGTACGTGCNGB; match class: 1 0.00418007904359443 407 51 8 0.156862745098039 0.0196560196560197
TF TF:M02012_1 Factor: HIF-1alpha; motif: NCACGT; match class: 1 0.00424302612985619 1770 53 16 0.30188679245283 0.00903954802259887
TF TF:M11075_1 Factor: Sohlh2; motif: NNCACGTGNN; match class: 1 0.0106062257499631 8043 29 23 0.793103448275862 0.00285962949148328
TF TF:M00236 Factor: Arnt; motif: NDDNNCACGTGNNNNN 0.0138738845027977 2210 34 13 0.382352941176471 0.00588235294117647
TF TF:M09864 Factor: arnt; motif: NTACGTGMC 0.0138738845027977 896 10 5 0.5 0.00558035714285714
TF TF:M03572 Factor: DEC1; motif: CNCACRTGASC 0.0138738845027977 6713 54 33 0.611111111111111 0.00491583494711753
TF TF:M09992_1 Factor: c-Myc; motif: NCCACGTGCNN; match class: 1 0.0143825991631435 1634 28 10 0.357142857142857 0.00611995104039168
TF TF:M05993 Factor: ZNF711; motif: NTGCGTGCGC 0.0143825991631435 38 37 3 0.0810810810810811 0.0789473684210526
TF TF:M11061 Factor: HES-1; motif: GGCRCGTGNC 0.0151185905814246 6271 53 31 0.584905660377358 0.0049433902088981
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.0175543711216443 10230 23 21 0.91304347826087 0.00205278592375367
TF TF:M01145_1 Factor: c-Myc; motif: RACCACGTGCTC; match class: 1 0.0190201473945842 3448 31 15 0.483870967741935 0.00435034802784223
TF TF:M00121 Factor: USF; motif: NNRYCACGTGRYNN 0.0203054821940938 2483 29 12 0.413793103448276 0.00483286347160693
TF TF:M04744 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA 0.0203054821940938 10089 38 31 0.815789473684211 0.00307265338487462
TF TF:M09820 Factor: USF2; motif: NNNGGTCACGTGRYNN 0.0203054821940938 2091 29 11 0.379310344827586 0.00526064084170253
TF TF:M11081_1 Factor: SREBP-1; motif: RTCRCGTGAY; match class: 1 0.0203054821940938 7890 51 34 0.666666666666667 0.00430925221799747
TF TF:M00466 Factor: HIF1; motif: NGTACGTGCNGB 0.0203054821940938 2997 51 19 0.372549019607843 0.00633967300633967
TF TF:M00121_1 Factor: USF; motif: NNRYCACGTGRYNN; match class: 1 0.0203054821940938 2483 29 12 0.413793103448276 0.00483286347160693
TF TF:M00940 Factor: E2F-1; motif: NTTTCGCGCS 0.0203054821940938 7802 53 35 0.660377358490566 0.00448602922327608
TF TF:M06887 Factor: MIZF; motif: WTGCGTG 0.0225965956703642 1499 46 12 0.260869565217391 0.00800533689126084
TF TF:M08767 Factor: HES-1; motif: GNCACGTGNC 0.0245262598882031 7813 35 25 0.714285714285714 0.00319979521310636
TF TF:M11066_1 Factor: HES-7; motif: GNCACGYGNN; match class: 1 0.0251699151159192 8172 52 35 0.673076923076923 0.00428291727851199
TF TF:M04744_1 Factor: ATF-3; motif: GGCGCSSNSNGRTSACGTSA; match class: 1 0.0270410177736613 4889 20 13 0.65 0.00265903047658008
TF TF:M01973 Factor: PLAG1; motif: CCCCCKWNNNGGSCCC 0.0270410177736613 6167 23 16 0.695652173913043 0.00259445435381871
TF TF:M04950 Factor: Egr-1; motif: NGCGTGCGY 0.0270410177736613 10935 38 32 0.842105263157895 0.00292638317329675
TF TF:M00322 Factor: c-Myc:Max; motif: GCCAYGYGSN 0.0270410177736613 7873 37 26 0.702702702702703 0.00330242601295567
TF TF:M01249_1 Factor: HIF2alpha; motif: NNACGTGCNN; match class: 1 0.0270410177736613 107 51 4 0.0784313725490196 0.0373831775700935
TF TF:M00187 Factor: USF; motif: GYCACGTGNC 0.0276615312243737 3775 34 16 0.470588235294118 0.00423841059602649
TF TF:M00032 Factor: c-Ets-1(p54); motif: NCMGGAWGYN 0.0276615312243737 7858 39 27 0.692307692307692 0.00343598880122168
TF TF:M01154_1 Factor: c-Myc; motif: KACCACGTGSYY; match class: 1 0.0276615312243737 3751 31 15 0.483870967741935 0.00399893361770195
TF TF:M08767_1 Factor: HES-1; motif: GNCACGTGNC; match class: 1 0.0276615312243737 7709 34 24 0.705882352941177 0.0031132442599559
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.0278201479194111 14106 40 38 0.95 0.00269388912519495
TF TF:M02011 Factor: HES-1; motif: GSCACGMGMC 0.0315674324308066 4259 37 18 0.486486486486487 0.0042263442122564
TF TF:M05622 Factor: HKR1; motif: GWNGTGSGRA 0.0344703090859415 385 17 4 0.235294117647059 0.0103896103896104
TF TF:M07601_1 Factor: C-Myc; motif: NGCCACGTGNN; match class: 1 0.0344703090859415 4180 29 15 0.517241379310345 0.00358851674641148
TF TF:M08223_1 Factor: Elk-1:OC-2; motif: RCCGGAASCGATCGATNN; match class: 1 0.0359844352553379 5853 29 18 0.620689655172414 0.00307534597642235
TF TF:M09640 Factor: NF-1C; motif: NYYTGGCWNNNNKCCMN 0.0402844621719426 2807 18 9 0.5 0.00320627003918774
TF TF:M00122_1 Factor: USF; motif: NNRNCACGTGNYNN; match class: 1 0.0428358542064667 2413 29 11 0.379310344827586 0.00455864069622876
TF TF:M00122 Factor: USF; motif: NNRNCACGTGNYNN 0.0428358542064667 2413 29 11 0.379310344827586 0.00455864069622876
TF TF:M09611 Factor: ER81; motif: NNNGRCMGGAAGYRNNNNNNNS 0.046548741801814 2666 23 10 0.434782608695652 0.00375093773443361
TF TF:M05381 Factor: ZNF826; motif: GKGCWGCAGM 0.046548741801814 677 53 8 0.150943396226415 0.0118168389955687
TF TF:M11090_1 Factor: TFEA; motif: YRCACGTGACN; match class: 1 0.0467262137946353 3393 29 13 0.448275862068966 0.00383141762452107
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 0.0467262137946353 5051 47 23 0.48936170212766 0.00455355375173233
TF TF:M00539 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN 0.0467262137946353 6676 31 20 0.645161290322581 0.00299580587177951
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.0467262137946353 10253 44 34 0.772727272727273 0.00331610260411587
TF TF:M00539_1 Factor: Arnt; motif: NNNNNRTCACGTGAYNNNNN; match class: 1 0.0467262137946353 6676 31 20 0.645161290322581 0.00299580587177951
TF TF:M08800 Factor: ARNT; motif: YRCGTGNN 0.0467262137946353 914 23 6 0.260869565217391 0.00656455142231947
TF TF:M09876_1 Factor: DEC1; motif: NGCACGTGAS; match class: 1 0.0467262137946353 6252 51 28 0.549019607843137 0.00447856685860525
TF TF:M00797_1 Factor: HIF1; motif: GNNKACGTGCGGNN; match class: 1 0.0467262137946353 549 51 7 0.137254901960784 0.0127504553734062
TF TF:M03815 Factor: c-Fos; motif: TGACTCAN 0.0467262137946353 2455 7 5 0.714285714285714 0.00203665987780041
WP WP:WP4629 Computational Model of Aerobic Glycolysis 1.79763859184606e-14 12 20 7 0.35 0.583333333333333
WP WP:WP534 Glycolysis and Gluconeogenesis 4.85100811620404e-11 45 26 8 0.307692307692308 0.177777777777778
WP WP:WP1946 Cori Cycle 5.01623766310911e-11 17 20 6 0.3 0.352941176470588
WP WP:WP4018 Pathways in clear cell renal cell carcinoma 2.74765812593566e-10 87 28 9 0.321428571428571 0.103448275862069
WP WP:WP5049 Glycolysis in senescence 2.41624003638958e-09 11 26 5 0.192307692307692 0.454545454545455
WP WP:WP2456 HIF1A and PPARG regulation of glycolysis 1.07902065314118e-07 8 5 3 0.6 0.375
WP WP:WP4290 Metabolic reprogramming in colon cancer 1.10311340583711e-07 44 28 6 0.214285714285714 0.136363636363636
WP WP:WP3614 Photodynamic therapy-induced HIF-1 survival signaling 0.00103199390267049 37 19 3 0.157894736842105 0.0810810810810811
WP WP:WP4698 Vitamin D-sensitive calcium signaling in depression 0.00566639028204846 40 32 3 0.09375 0.075
WP WP:WP3888 VEGFA-VEGFR2 Signaling Pathway 0.00576904204150536 437 20 6 0.3 0.0137299771167048
WP WP:WP176 Folate Metabolism 0.0245484980837589 73 33 3 0.0909090909090909 0.0410958904109589

pEpi13 transcription factor target enrichment of top program genes

TF enrichment of pEpi13
Possible regulators of activation of pEpi13 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.