pEpiTp26 program activity among Epithelial cells

Activation of pEpiTp26
pEpiTp26 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp26 by different cell subtypes
pEpiTp26 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp26 top program genes

Top genes of pEpiTp26 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp26 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp26
pEpiTp26 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0019674 NAD metabolic process 3.20351727651791e-05 52 56 6 0.107142857142857 0.115384615384615
GO:BP GO:0002283 neutrophil activation involved in immune response 0.000265271893462795 485 20 7 0.35 0.0144329896907217
GO:BP GO:0002446 neutrophil mediated immunity 0.000265271893462795 497 20 7 0.35 0.0140845070422535
GO:BP GO:0036230 granulocyte activation 0.000265271893462795 504 20 7 0.35 0.0138888888888889
GO:BP GO:0042119 neutrophil activation 0.000265271893462795 498 20 7 0.35 0.0140562248995984
GO:BP GO:0006734 NADH metabolic process 0.000265271893462795 46 56 5 0.0892857142857143 0.108695652173913
GO:BP GO:0043312 neutrophil degranulation 0.000265271893462795 482 20 7 0.35 0.0145228215767635
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.000277953119349726 547 20 7 0.35 0.0127970749542962
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.000277953119349726 551 20 7 0.35 0.0127041742286751
GO:BP GO:0061621 canonical glycolysis 0.000277953119349726 27 56 4 0.0714285714285714 0.148148148148148
GO:BP GO:0006735 NADH regeneration 0.000277953119349726 27 56 4 0.0714285714285714 0.148148148148148
GO:BP GO:0061718 glucose catabolic process to pyruvate 0.000277953119349726 27 56 4 0.0714285714285714 0.148148148148148
GO:BP GO:0043299 leukocyte degranulation 0.000277953119349726 535 20 7 0.35 0.0130841121495327
GO:BP GO:0061620 glycolytic process through glucose-6-phosphate 0.000300425114330745 28 56 4 0.0714285714285714 0.142857142857143
GO:BP GO:0061615 glycolytic process through fructose-6-phosphate 0.000324514142971643 29 56 4 0.0714285714285714 0.137931034482759
GO:BP GO:0006887 exocytosis 0.000454855204361298 904 20 8 0.4 0.00884955752212389
GO:BP GO:0006007 glucose catabolic process 0.000667342487053285 36 56 4 0.0714285714285714 0.111111111111111
GO:BP GO:0002274 myeloid leukocyte activation 0.000667342487053285 667 20 7 0.35 0.0104947526236882
GO:BP GO:0032940 secretion by cell 0.000828125147835428 1364 20 9 0.45 0.00659824046920821
GO:BP GO:0002366 leukocyte activation involved in immune response 0.000954914424960659 717 20 7 0.35 0.0097629009762901
GO:BP GO:0002263 cell activation involved in immune response 0.000954914424960659 721 20 7 0.35 0.00970873786407767
GO:BP GO:0140352 export from cell 0.000983935716882024 1418 20 9 0.45 0.00634696755994358
GO:BP GO:0019320 hexose catabolic process 0.00131751465890213 57 94 5 0.0531914893617021 0.087719298245614
GO:BP GO:0046903 secretion 0.00139908496461487 1501 20 9 0.45 0.00599600266489007
GO:BP GO:0045055 regulated exocytosis 0.00139908496461487 785 20 7 0.35 0.0089171974522293
GO:BP GO:0046031 ADP metabolic process 0.00152264018955471 123 78 6 0.0769230769230769 0.0487804878048781
GO:BP GO:0046365 monosaccharide catabolic process 0.00183840137297684 63 94 5 0.0531914893617021 0.0793650793650794
GO:BP GO:0046939 nucleotide phosphorylation 0.00223889630276375 135 78 6 0.0769230769230769 0.0444444444444444
GO:BP GO:0009135 purine nucleoside diphosphate metabolic process 0.00223889630276375 136 78 6 0.0769230769230769 0.0441176470588235
GO:BP GO:0002443 leukocyte mediated immunity 0.00223889630276375 877 20 7 0.35 0.00798175598631699
GO:BP GO:0009179 purine ribonucleoside diphosphate metabolic process 0.00223889630276375 136 78 6 0.0769230769230769 0.0441176470588235
GO:BP GO:0006096 glycolytic process 0.00223889630276375 115 56 5 0.0892857142857143 0.0434782608695652
GO:BP GO:0006165 nucleoside diphosphate phosphorylation 0.00223889630276375 134 78 6 0.0769230769230769 0.0447761194029851
GO:BP GO:0009185 ribonucleoside diphosphate metabolic process 0.0022635726352159 139 78 6 0.0769230769230769 0.0431654676258993
GO:BP GO:0006757 ATP generation from ADP 0.0022635726352159 116 56 5 0.0892857142857143 0.0431034482758621
GO:BP GO:0016192 vesicle-mediated transport 0.00269854725968522 2180 20 10 0.5 0.00458715596330275
GO:BP GO:0035722 interleukin-12-mediated signaling pathway 0.00287013781952624 47 74 4 0.0540540540540541 0.0851063829787234
GO:BP GO:0002252 immune effector process 0.00291051411601362 1309 20 8 0.4 0.00611153552330023
GO:BP GO:0071349 cellular response to interleukin-12 0.00321464080879481 49 74 4 0.0540540540540541 0.0816326530612245
GO:BP GO:0070671 response to interleukin-12 0.00339632818524462 50 74 4 0.0540540540540541 0.08
GO:BP GO:0006413 translational initiation 0.00385556896518725 201 38 5 0.131578947368421 0.0248756218905473
GO:BP GO:0009132 nucleoside diphosphate metabolic process 0.00386535948927743 158 78 6 0.0769230769230769 0.0379746835443038
GO:BP GO:0009743 response to carbohydrate 0.00403982268568798 243 17 4 0.235294117647059 0.0164609053497942
GO:BP GO:0042273 ribosomal large subunit biogenesis 0.00418791399489854 74 54 4 0.0740740740740741 0.0540540540540541
GO:BP GO:0051649 establishment of localization in cell 0.00595476436939822 2813 35 15 0.428571428571429 0.0053323853537149
GO:BP GO:0006090 pyruvate metabolic process 0.00595476436939822 151 56 5 0.0892857142857143 0.033112582781457
GO:BP GO:0043933 protein-containing complex subunit organization 0.00727016708041134 1963 54 16 0.296296296296296 0.00815078960774325
GO:BP GO:1902305 regulation of sodium ion transmembrane transport 0.00840646672601264 63 30 3 0.1 0.0476190476190476
GO:BP GO:0009205 purine ribonucleoside triphosphate metabolic process 0.0086188902541614 84 23 3 0.130434782608696 0.0357142857142857
GO:BP GO:0006094 gluconeogenesis 0.00872180700929217 89 56 4 0.0714285714285714 0.0449438202247191
GO:BP GO:0019319 hexose biosynthetic process 0.00971841632252077 92 56 4 0.0714285714285714 0.0434782608695652
GO:BP GO:0009144 purine nucleoside triphosphate metabolic process 0.00996394870087173 90 23 3 0.130434782608696 0.0333333333333333
GO:BP GO:0009199 ribonucleoside triphosphate metabolic process 0.0101008580087891 91 23 3 0.130434782608696 0.032967032967033
GO:BP GO:0016032 viral process 0.011048293230625 942 33 8 0.242424242424242 0.00849256900212314
GO:BP GO:0032680 regulation of tumor necrosis factor production 0.0110878668112953 163 96 6 0.0625 0.0368098159509202
GO:BP GO:0046364 monosaccharide biosynthetic process 0.0112861485000745 98 56 4 0.0714285714285714 0.0408163265306122
GO:BP GO:0032640 tumor necrosis factor production 0.0114269411922261 165 96 6 0.0625 0.0363636363636364
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.0119833032142438 167 96 6 0.0625 0.0359281437125748
GO:BP GO:2001243 negative regulation of intrinsic apoptotic signaling pathway 0.0119876759252133 100 23 3 0.130434782608696 0.03
GO:BP GO:0065003 protein-containing complex assembly 0.0121407273987953 1680 36 11 0.305555555555556 0.00654761904761905
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.0121407273987953 170 96 6 0.0625 0.0352941176470588
GO:BP GO:0006936 muscle contraction 0.0121407273987953 364 106 9 0.0849056603773585 0.0247252747252747
GO:BP GO:0033574 response to testosterone 0.0133032371038335 44 55 3 0.0545454545454545 0.0681818181818182
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.0138722663495071 1001 33 8 0.242424242424242 0.00799200799200799
GO:BP GO:0046034 ATP metabolic process 0.0139895279137405 314 100 8 0.08 0.0254777070063694
GO:BP GO:0016052 carbohydrate catabolic process 0.0142590758155586 198 56 5 0.0892857142857143 0.0252525252525253
GO:BP GO:0045321 leukocyte activation 0.0145634562415074 1332 20 7 0.35 0.00525525525525526
GO:BP GO:0002028 regulation of sodium ion transport 0.0145634562415074 87 30 3 0.1 0.0344827586206897
GO:BP GO:0006955 immune response 0.0145634562415074 2311 20 9 0.45 0.00389441800086543
GO:BP GO:0007569 cell aging 0.0145634562415074 117 96 5 0.0520833333333333 0.0427350427350427
GO:BP GO:0009141 nucleoside triphosphate metabolic process 0.0145634562415074 113 23 3 0.130434782608696 0.0265486725663717
GO:BP GO:0003012 muscle system process 0.0159868291815231 471 106 10 0.0943396226415094 0.0212314225053079
GO:BP GO:0006006 glucose metabolic process 0.0172660632816037 211 56 5 0.0892857142857143 0.023696682464455
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 0.0220314509545716 96 32 3 0.09375 0.03125
GO:BP GO:0001775 cell activation 0.024683882888387 1495 20 7 0.35 0.00468227424749164
GO:BP GO:0006613 cotranslational protein targeting to membrane 0.024683882888387 102 32 3 0.09375 0.0294117647058824
GO:BP GO:0030838 positive regulation of actin filament polymerization 0.0249643387230011 104 72 4 0.0555555555555556 0.0384615384615385
GO:BP GO:0051641 cellular localization 0.0256744427574313 3541 37 16 0.432432432432432 0.00451849759954815
GO:BP GO:0009749 response to glucose 0.0256744427574313 202 17 3 0.176470588235294 0.0148514851485149
GO:BP GO:0031667 response to nutrient levels 0.0256744427574313 482 93 9 0.0967741935483871 0.0186721991701245
GO:BP GO:0032787 monocarboxylic acid metabolic process 0.0263244788673581 658 56 8 0.142857142857143 0.0121580547112462
GO:BP GO:0014075 response to amine 0.0263244788673581 46 74 3 0.0405405405405405 0.0652173913043478
GO:BP GO:0009746 response to hexose 0.0268633582317048 209 17 3 0.176470588235294 0.0143540669856459
GO:BP GO:0019752 carboxylic acid metabolic process 0.0268633582317048 1024 46 9 0.195652173913043 0.0087890625
GO:BP GO:0051260 protein homooligomerization 0.0270451318259746 180 20 3 0.15 0.0166666666666667
GO:BP GO:0034284 response to monosaccharide 0.0270451318259746 215 17 3 0.176470588235294 0.013953488372093
GO:BP GO:0045047 protein targeting to ER 0.0275152212702464 113 32 3 0.09375 0.0265486725663717
GO:BP GO:0006810 transport 0.0281195763220674 5224 32 18 0.5625 0.00344563552833078
GO:BP GO:0006412 translation 0.0282482745501723 764 50 8 0.16 0.0104712041884817
GO:BP GO:0019318 hexose metabolic process 0.0283706761622002 253 56 5 0.0892857142857143 0.0197628458498024
GO:BP GO:0002376 immune system process 0.0286768375234435 3278 20 10 0.5 0.00305064063453325
GO:BP GO:0043436 oxoacid metabolic process 0.0286768375234435 1057 46 9 0.195652173913043 0.00851466414380322
GO:BP GO:0044282 small molecule catabolic process 0.0286768375234435 439 107 9 0.0841121495327103 0.020501138952164
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 0.0286768375234435 117 32 3 0.09375 0.0256410256410256
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.0286797061309844 167 23 3 0.130434782608696 0.0179640718562874
GO:BP GO:0042493 response to drug 0.0287566538021023 396 22 4 0.181818181818182 0.0101010101010101
GO:BP GO:0009991 response to extracellular stimulus 0.0295206056701724 512 93 9 0.0967741935483871 0.017578125
GO:BP GO:0048519 negative regulation of biological process 0.0295206056701724 5757 39 22 0.564102564102564 0.00382143477505645
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 0.0302192023539417 123 32 3 0.09375 0.024390243902439
GO:BP GO:0043043 peptide biosynthetic process 0.0302192023539417 790 50 8 0.16 0.010126582278481
GO:BP GO:0051234 establishment of localization 0.0318380329625332 5372 32 18 0.5625 0.00335070737155622
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0318380329625332 2255 33 11 0.333333333333333 0.0048780487804878
GO:BP GO:0045010 actin nucleation 0.0318380329625332 57 72 3 0.0416666666666667 0.0526315789473684
GO:BP GO:0006082 organic acid metabolic process 0.0318380329625332 1090 46 9 0.195652173913043 0.00825688073394495
GO:BP GO:0051301 cell division 0.0318380329625332 622 37 6 0.162162162162162 0.00964630225080386
GO:BP GO:0006886 intracellular protein transport 0.032510625031529 1186 35 8 0.228571428571429 0.00674536256323777
GO:BP GO:0005996 monosaccharide metabolic process 0.0325293002888698 276 56 5 0.0892857142857143 0.0181159420289855
GO:BP GO:0009150 purine ribonucleotide metabolic process 0.0326400277587732 414 23 4 0.173913043478261 0.00966183574879227
GO:BP GO:1901575 organic substance catabolic process 0.0326400277587732 2267 38 12 0.315789473684211 0.00529333921482135
GO:BP GO:0007568 aging 0.0343088628659459 329 96 7 0.0729166666666667 0.0212765957446809
GO:BP GO:0009259 ribonucleotide metabolic process 0.0352444079277693 431 23 4 0.173913043478261 0.00928074245939675
GO:BP GO:0051259 protein complex oligomerization 0.0365845820479658 234 20 3 0.15 0.0128205128205128
GO:BP GO:0032651 regulation of interleukin-1 beta production 0.0366373561888437 102 96 4 0.0416666666666667 0.0392156862745098
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.0366373561888437 1853 53 13 0.245283018867925 0.00701565029681597
GO:BP GO:0042254 ribosome biogenesis 0.0366373561888437 307 54 5 0.0925925925925926 0.0162866449511401
GO:BP GO:0070972 protein localization to endoplasmic reticulum 0.0366373561888437 146 32 3 0.09375 0.0205479452054795
GO:BP GO:0019693 ribose phosphate metabolic process 0.0366373561888437 441 23 4 0.173913043478261 0.0090702947845805
GO:BP GO:0006163 purine nucleotide metabolic process 0.0381289198034037 450 23 4 0.173913043478261 0.00888888888888889
GO:BP GO:0032273 positive regulation of protein polymerization 0.0395529490973294 141 72 4 0.0555555555555556 0.0283687943262411
GO:BP GO:0032271 regulation of protein polymerization 0.0398870774215151 236 72 5 0.0694444444444444 0.0211864406779661
GO:BP GO:0032611 interleukin-1 beta production 0.0400866745903274 107 96 4 0.0416666666666667 0.0373831775700935
GO:BP GO:0044085 cellular component biogenesis 0.0403472889584369 3257 36 14 0.388888888888889 0.00429843414184833
GO:BP GO:0007566 embryo implantation 0.0421520026093126 54 94 3 0.0319148936170213 0.0555555555555556
GO:BP GO:0035725 sodium ion transmembrane transport 0.0421520026093126 171 30 3 0.1 0.0175438596491228
GO:BP GO:0042981 regulation of apoptotic process 0.0421520026093126 1549 8 4 0.5 0.0025823111684958
GO:BP GO:0072521 purine-containing compound metabolic process 0.0421520026093126 473 23 4 0.173913043478261 0.00845665961945032
GO:BP GO:0043066 negative regulation of apoptotic process 0.0421520026093126 921 106 13 0.122641509433962 0.0141150922909881
GO:BP GO:0009056 catabolic process 0.0438466862920359 2744 56 17 0.303571428571429 0.00619533527696793
GO:BP GO:0043067 regulation of programmed cell death 0.0438466862920359 1582 8 4 0.5 0.00252844500632111
GO:BP GO:2001234 negative regulation of apoptotic signaling pathway 0.0444979159162537 236 23 3 0.130434782608696 0.0127118644067797
GO:BP GO:0008360 regulation of cell shape 0.0447749043799076 154 72 4 0.0555555555555556 0.025974025974026
GO:BP GO:0032652 regulation of interleukin-1 production 0.0451853917943804 119 96 4 0.0416666666666667 0.0336134453781513
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0451853917943804 1132 33 7 0.212121212121212 0.00618374558303887
GO:BP GO:0043069 negative regulation of programmed cell death 0.0451853917943804 943 106 13 0.122641509433962 0.0137857900318134
GO:BP GO:0043604 amide biosynthetic process 0.0451853917943804 932 50 8 0.16 0.00858369098712446
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0460857067890937 549 35 5 0.142857142857143 0.00910746812386157
GO:BP GO:0019083 viral transcription 0.0464290876573943 181 32 3 0.09375 0.0165745856353591
GO:BP GO:0043030 regulation of macrophage activation 0.0464290876573943 65 88 3 0.0340909090909091 0.0461538461538462
GO:BP GO:0010941 regulation of cell death 0.0476444337802577 1720 8 4 0.5 0.00232558139534884
GO:BP GO:0016051 carbohydrate biosynthetic process 0.0489701984827948 214 56 4 0.0714285714285714 0.0186915887850467
GO:BP GO:0006518 peptide metabolic process 0.0490454683821865 955 50 8 0.16 0.00837696335078534
GO:BP GO:0006091 generation of precursor metabolites and energy 0.0490454683821865 538 23 4 0.173913043478261 0.00743494423791822
GO:BP GO:0009117 nucleotide metabolic process 0.0498133056772451 544 23 4 0.173913043478261 0.00735294117647059
GO:BP GO:0032612 interleukin-1 production 0.0498133056772451 126 96 4 0.0416666666666667 0.0317460317460317
GO:CC GO:0043230 extracellular organelle 1.11683899017003e-06 2263 57 24 0.421052631578947 0.0106053910737958
GO:CC GO:0070062 extracellular exosome 1.11683899017003e-06 2176 57 24 0.421052631578947 0.0110294117647059
GO:CC GO:1903561 extracellular vesicle 1.11683899017003e-06 2261 57 24 0.421052631578947 0.0106147722246793
GO:CC GO:0099503 secretory vesicle 3.3407061024792e-05 1020 20 9 0.45 0.00882352941176471
GO:CC GO:0031982 vesicle 5.19919275351735e-05 4055 40 23 0.575 0.00567200986436498
GO:CC GO:0030141 secretory granule 7.73307377027295e-05 851 20 8 0.4 0.00940070505287897
GO:CC GO:0031430 M band 0.000380462189684892 25 102 4 0.0392156862745098 0.16
GO:CC GO:0031410 cytoplasmic vesicle 0.000380462189684892 2424 20 11 0.55 0.00453795379537954
GO:CC GO:0097708 intracellular vesicle 0.000380462189684892 2428 20 11 0.55 0.00453047775947282
GO:CC GO:0034774 secretory granule lumen 0.000525734108108645 320 20 5 0.25 0.015625
GO:CC GO:0015934 large ribosomal subunit 0.000525734108108645 118 50 5 0.1 0.0423728813559322
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.000525734108108645 324 20 5 0.25 0.0154320987654321
GO:CC GO:0031983 vesicle lumen 0.000525734108108645 326 20 5 0.25 0.0153374233128834
GO:CC GO:0070820 tertiary granule 0.000571223688747927 163 20 4 0.2 0.0245398773006135
GO:CC GO:0101002 ficolin-1-rich granule 0.000571223688747927 184 59 6 0.101694915254237 0.0326086956521739
GO:CC GO:0005829 cytosol 0.000635145426772292 5303 38 23 0.605263157894737 0.00433716764095795
GO:CC GO:0005615 extracellular space 0.000851290592844137 3594 40 19 0.475 0.00528658875904285
GO:CC GO:1904813 ficolin-1-rich granule lumen 0.000865273322792101 124 59 5 0.0847457627118644 0.0403225806451613
GO:CC GO:0031672 A band 0.00110597075169103 39 102 4 0.0392156862745098 0.102564102564103
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.00132848143423731 5338 67 34 0.507462686567164 0.00636942675159236
GO:CC GO:0099738 cell cortex region 0.00132848143423731 42 37 3 0.0810810810810811 0.0714285714285714
GO:CC GO:0043228 non-membrane-bounded organelle 0.00132848143423731 5346 67 34 0.507462686567164 0.00635989524878414
GO:CC GO:0005576 extracellular region 0.00192460333193367 4567 106 43 0.405660377358491 0.00941537114079264
GO:CC GO:0022625 cytosolic large ribosomal subunit 0.00192460333193367 57 32 3 0.09375 0.0526315789473684
GO:CC GO:0044391 ribosomal subunit 0.00210798113868261 190 50 5 0.1 0.0263157894736842
GO:CC GO:0005938 cell cortex 0.00254106564850827 311 72 7 0.0972222222222222 0.022508038585209
GO:CC GO:1904724 tertiary granule lumen 0.00444615826948074 55 46 3 0.0652173913043478 0.0545454545454545
GO:CC GO:0015629 actin cytoskeleton 0.00588197302239536 513 102 10 0.0980392156862745 0.0194931773879142
GO:CC GO:0005840 ribosome 0.00588197302239536 245 50 5 0.1 0.0204081632653061
GO:CC GO:0022626 cytosolic ribosome 0.010122092136246 109 32 3 0.09375 0.0275229357798165
GO:CC GO:0098858 actin-based cell projection 0.0106008307179185 220 64 5 0.078125 0.0227272727272727
GO:CC GO:0030017 sarcomere 0.0106492657387814 208 102 6 0.0588235294117647 0.0288461538461538
GO:CC GO:0005902 microvillus 0.0110232067510545 91 41 3 0.0731707317073171 0.032967032967033
GO:CC GO:0045202 synapse 0.0142521600161337 1349 32 8 0.25 0.00593031875463306
GO:CC GO:0030016 myofibril 0.0149596320207022 231 102 6 0.0588235294117647 0.025974025974026
GO:CC GO:0099568 cytoplasmic region 0.016930577262301 269 37 4 0.108108108108108 0.0148698884758364
GO:CC GO:0043292 contractile fiber 0.0172617271463182 240 102 6 0.0588235294117647 0.025
GO:CC GO:1990904 ribonucleoprotein complex 0.0183871861052843 688 50 7 0.14 0.0101744186046512
GO:CC GO:0012505 endomembrane system 0.020443290860196 4640 22 12 0.545454545454545 0.00258620689655172
GO:CC GO:0030864 cortical actin cytoskeleton 0.0287067679413875 79 72 3 0.0416666666666667 0.0379746835443038
GO:CC GO:0043233 organelle lumen 0.0329383905978035 5565 103 43 0.41747572815534 0.00772686433063792
GO:CC GO:0005730 nucleolus 0.0329383905978035 955 76 10 0.131578947368421 0.0104712041884817
GO:CC GO:0031974 membrane-enclosed lumen 0.0329383905978035 5565 103 43 0.41747572815534 0.00772686433063792
GO:CC GO:0031253 cell projection membrane 0.0329383905978035 343 19 3 0.157894736842105 0.0087463556851312
GO:CC GO:0043227 membrane-bounded organelle 0.0421015940195867 12858 59 49 0.830508474576271 0.00381085705397418
GO:CC GO:0016020 membrane 0.0423687585828378 9838 45 32 0.711111111111111 0.00325269363691807
GO:CC GO:0030863 cortical cytoskeleton 0.0459324837689222 107 72 3 0.0416666666666667 0.0280373831775701
GO:CC GO:0099080 supramolecular complex 0.0463481376692731 1323 34 7 0.205882352941176 0.00529100529100529
GO:CC GO:0032991 protein-containing complex 0.049452973718507 5548 37 18 0.486486486486487 0.00324441240086518
GO:CC GO:0044309 neuron spine 0.049452973718507 185 84 4 0.0476190476190476 0.0216216216216216
GO:CC GO:0043197 dendritic spine 0.049452973718507 183 84 4 0.0476190476190476 0.0218579234972678
GO:MF GO:0045296 cadherin binding 1.22133557335523e-06 333 32 9 0.28125 0.027027027027027
GO:MF GO:0050839 cell adhesion molecule binding 2.90108710524949e-06 546 32 10 0.3125 0.0183150183150183
GO:MF GO:0003723 RNA binding 0.00158071818705781 1943 33 13 0.393939393939394 0.00669068450849202
GO:MF GO:0003735 structural constituent of ribosome 0.00703988073754454 171 50 5 0.1 0.0292397660818713
GO:MF GO:0016829 lyase activity 0.00803782815385432 203 107 7 0.0654205607476635 0.0344827586206897
GO:MF GO:0042802 identical protein binding 0.0100749499133856 2067 10 6 0.6 0.00290275761973875
GO:MF GO:0005198 structural molecule activity 0.0169883215202671 698 50 8 0.16 0.0114613180515759
GO:MF GO:0000287 magnesium ion binding 0.0181927989396104 222 35 4 0.114285714285714 0.018018018018018
GO:MF GO:0016835 carbon-oxygen lyase activity 0.0219666821518064 81 107 4 0.0373831775700935 0.0493827160493827
GO:MF GO:0008092 cytoskeletal protein binding 0.0281057002262434 996 102 13 0.127450980392157 0.0130522088353414
GO:MF GO:0003779 actin binding 0.0281057002262434 448 102 8 0.0784313725490196 0.0178571428571429
GO:MF GO:0017111 nucleoside-triphosphatase activity 0.0298143906255108 872 33 6 0.181818181818182 0.00688073394495413
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0312510728335299 930 33 6 0.181818181818182 0.00645161290322581
GO:MF GO:0016462 pyrophosphatase activity 0.0312510728335299 928 33 6 0.181818181818182 0.00646551724137931
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.0312510728335299 930 33 6 0.181818181818182 0.00645161290322581
GO:MF GO:0051015 actin filament binding 0.0323033369450805 212 102 5 0.0490196078431373 0.0235849056603774
GO:MF GO:0016836 hydro-lyase activity 0.0323033369450805 65 107 3 0.0280373831775701 0.0461538461538462
GO:MF GO:1901363 heterocyclic compound binding 0.0415937391762004 6228 33 18 0.545454545454545 0.00289017341040462
GO:MF GO:0019899 enzyme binding 0.0421203275067452 2074 23 7 0.304347826086957 0.00337512054001929
GO:MF GO:0003676 nucleic acid binding 0.0432690665366938 4276 43 17 0.395348837209302 0.00397567820392891
GO:MF GO:0097159 organic cyclic compound binding 0.0433706771586585 6309 33 18 0.545454545454545 0.00285306704707561
GO:MF GO:0019904 protein domain specific binding 0.0471415428950079 710 37 5 0.135135135135135 0.00704225352112676
KEGG KEGG:00010 Glycolysis / Gluconeogenesis 0.012635174355204 67 56 5 0.0892857142857143 0.0746268656716418
KEGG KEGG:01230 Biosynthesis of amino acids 0.0171300939904066 75 96 6 0.0625 0.08
MIRNA MIRNA:hsa-miR-200b-5p hsa-miR-200b-5p 0.0347402093489739 54 20 3 0.15 0.0555555555555556
MIRNA MIRNA:hsa-miR-367-3p hsa-miR-367-3p 0.0347402093489739 329 51 7 0.137254901960784 0.0212765957446809
MIRNA MIRNA:hsa-miR-324-5p hsa-miR-324-5p 0.0347402093489739 297 42 6 0.142857142857143 0.0202020202020202
MIRNA MIRNA:hsa-miR-4253 hsa-miR-4253 0.0347402093489739 69 25 3 0.12 0.0434782608695652
MIRNA MIRNA:hsa-miR-4443 hsa-miR-4443 0.0347402093489739 107 34 4 0.117647058823529 0.0373831775700935
MIRNA MIRNA:hsa-miR-363-3p hsa-miR-363-3p 0.0347402093489739 340 51 7 0.137254901960784 0.0205882352941176
MIRNA MIRNA:hsa-miR-6862-5p hsa-miR-6862-5p 0.0347402093489739 68 25 3 0.12 0.0441176470588235
MIRNA MIRNA:hsa-miR-744-5p hsa-miR-744-5p 0.0347402093489739 435 36 7 0.194444444444444 0.0160919540229885
MIRNA MIRNA:hsa-miR-320c hsa-miR-320c 0.0360537791254397 108 42 4 0.0952380952380952 0.037037037037037
MIRNA MIRNA:hsa-miR-325 hsa-miR-325 0.0368667392367509 32 59 3 0.0508474576271186 0.09375
MIRNA MIRNA:hsa-miR-92b-3p hsa-miR-92b-3p 0.0409278233889259 707 38 8 0.210526315789474 0.0113154172560113
MIRNA MIRNA:hsa-miR-34a-5p hsa-miR-34a-5p 0.047129073579242 728 15 5 0.333333333333333 0.00686813186813187
MIRNA MIRNA:hsa-miR-32-5p hsa-miR-32-5p 0.047129073579242 563 38 7 0.184210526315789 0.0124333925399645
MIRNA MIRNA:hsa-miR-577 hsa-miR-577 0.047129073579242 128 19 3 0.157894736842105 0.0234375
MIRNA MIRNA:hsa-miR-4255 hsa-miR-4255 0.047129073579242 80 30 3 0.1 0.0375
MIRNA MIRNA:hsa-miR-548aj-3p hsa-miR-548aj-3p 0.0473617807902747 291 40 5 0.125 0.0171821305841924
MIRNA MIRNA:hsa-miR-548am-3p hsa-miR-548am-3p 0.0473617807902747 289 40 5 0.125 0.0173010380622837
MIRNA MIRNA:hsa-miR-548aq-3p hsa-miR-548aq-3p 0.0473617807902747 291 40 5 0.125 0.0171821305841924
MIRNA MIRNA:hsa-miR-548j-3p hsa-miR-548j-3p 0.0473617807902747 290 40 5 0.125 0.0172413793103448
MIRNA MIRNA:hsa-miR-548x-3p hsa-miR-548x-3p 0.0473617807902747 291 40 5 0.125 0.0171821305841924
MIRNA MIRNA:hsa-miR-5571-5p hsa-miR-5571-5p 0.0473617807902747 216 29 4 0.137931034482759 0.0185185185185185
MIRNA MIRNA:hsa-miR-548ae-3p hsa-miR-548ae-3p 0.0473617807902747 291 40 5 0.125 0.0171821305841924
MIRNA MIRNA:hsa-miR-25-3p hsa-miR-25-3p 0.0473617807902747 515 60 8 0.133333333333333 0.0155339805825243
MIRNA MIRNA:hsa-miR-524-5p hsa-miR-524-5p 0.0473617807902747 171 64 5 0.078125 0.0292397660818713
MIRNA MIRNA:hsa-miR-520d-5p hsa-miR-520d-5p 0.0473617807902747 164 64 5 0.078125 0.0304878048780488
MIRNA MIRNA:hsa-miR-193b-5p hsa-miR-193b-5p 0.0473617807902747 212 28 4 0.142857142857143 0.0188679245283019
MIRNA MIRNA:hsa-miR-548ah-3p hsa-miR-548ah-3p 0.0473617807902747 289 40 5 0.125 0.0173010380622837
REAC REAC:R-HSA-70263 Gluconeogenesis 0.00441259745959145 32 56 4 0.0714285714285714 0.125
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.00441259745959145 474 20 7 0.35 0.0147679324894515
REAC REAC:R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 0.0128116926416144 36 74 4 0.0540540540540541 0.111111111111111
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 0.017665982424328 113 33 4 0.121212121212121 0.0353982300884956
REAC REAC:R-HSA-9020591 Interleukin-12 signaling 0.017665982424328 45 74 4 0.0540540540540541 0.0888888888888889
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 0.017665982424328 120 33 4 0.121212121212121 0.0333333333333333
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 0.017665982424328 120 33 4 0.121212121212121 0.0333333333333333
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 0.017665982424328 112 33 4 0.121212121212121 0.0357142857142857
REAC REAC:R-HSA-447115 Interleukin-12 family signaling 0.017665982424328 55 30 3 0.1 0.0545454545454545
REAC REAC:R-HSA-70171 Glycolysis 0.017665982424328 67 56 4 0.0714285714285714 0.0597014925373134
REAC REAC:R-HSA-168255 Influenza Infection 0.0322156298621827 152 32 4 0.125 0.0263157894736842
REAC REAC:R-HSA-70326 Glucose metabolism 0.0322156298621827 85 56 4 0.0714285714285714 0.0470588235294118
REAC REAC:R-HSA-192823 Viral mRNA Translation 0.0476291232243042 90 32 3 0.09375 0.0333333333333333
REAC REAC:R-HSA-72766 Translation 0.0476291232243042 292 50 6 0.12 0.0205479452054795
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 0.0476291232243042 94 32 3 0.09375 0.0319148936170213
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 0.0476291232243042 94 32 3 0.09375 0.0319148936170213
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 0.0476291232243042 96 32 3 0.09375 0.03125
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 0.0476291232243042 368 40 6 0.15 0.016304347826087
REAC REAC:R-HSA-1430728 Metabolism 0.0476291232243042 2070 41 16 0.390243902439024 0.00772946859903382
REAC REAC:R-HSA-168249 Innate Immune System 0.0476291232243042 1073 20 7 0.35 0.0065237651444548
REAC REAC:R-HSA-168256 Immune System 0.0476291232243042 2139 20 10 0.5 0.00467508181393174
REAC REAC:R-HSA-156902 Peptide chain elongation 0.0476291232243042 90 32 3 0.09375 0.0333333333333333
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 0.0476291232243042 94 32 3 0.09375 0.0319148936170213
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 0.0476911790277053 102 32 3 0.09375 0.0294117647058824
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 0.0476911790277053 102 32 3 0.09375 0.0294117647058824
WP WP:WP4629 Computational Model of Aerobic Glycolysis 0.000198629291850629 12 56 4 0.0714285714285714 0.333333333333333
WP WP:WP534 Glycolysis and Gluconeogenesis 0.00140407618887799 45 56 5 0.0892857142857143 0.111111111111111
WP WP:WP5049 Glycolysis in senescence 0.00174529810147452 11 46 3 0.0652173913043478 0.272727272727273
WP WP:WP1946 Cori Cycle 0.00947022530777786 17 56 3 0.0535714285714286 0.176470588235294
WP WP:WP4018 Pathways in clear cell renal cell carcinoma 0.013421918199777 87 56 5 0.0892857142857143 0.0574712643678161

pEpiTp26 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp26
Possible regulators of activation of pEpiTp26 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.