pTNI02 program activity among T/NK/ILC cells

Activation of pTNI02
pTNI02 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI02 by different cell subtypes
pTNI02 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI02 top program genes

Top genes of pTNI02 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI02 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI02
pTNI02 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0019221 cytokine-mediated signaling pathway 9.61002240353026e-11 810 10 10 1 0.0123456790123457
GO:BP GO:0071345 cellular response to cytokine stimulus 1.97440837273983e-10 1132 146 37 0.253424657534247 0.0326855123674912
GO:BP GO:0034097 response to cytokine 2.95672788115369e-10 1226 146 38 0.26027397260274 0.0309951060358891
GO:BP GO:0042110 T cell activation 5.74851874171838e-10 489 85 19 0.223529411764706 0.0388548057259714
GO:BP GO:0046649 lymphocyte activation 5.74851874171838e-10 771 86 23 0.267441860465116 0.0298313878080415
GO:BP GO:0050863 regulation of T cell activation 2.96988674948613e-09 337 133 19 0.142857142857143 0.056379821958457
GO:BP GO:0002703 regulation of leukocyte mediated immunity 6.48925292283054e-09 205 129 15 0.116279069767442 0.0731707317073171
GO:BP GO:0002694 regulation of leukocyte activation 6.48925292283054e-09 610 134 24 0.17910447761194 0.039344262295082
GO:BP GO:0045321 leukocyte activation 6.48925292283054e-09 1332 146 37 0.253424657534247 0.0277777777777778
GO:BP GO:0001816 cytokine production 7.95705370013863e-09 844 146 29 0.198630136986301 0.0343601895734597
GO:BP GO:0001775 cell activation 7.95705370013863e-09 1495 146 39 0.267123287671233 0.0260869565217391
GO:BP GO:0051249 regulation of lymphocyte activation 8.51750742216547e-09 518 134 22 0.164179104477612 0.0424710424710425
GO:BP GO:0007159 leukocyte cell-cell adhesion 8.73876331512886e-09 375 133 19 0.142857142857143 0.0506666666666667
GO:BP GO:0002682 regulation of immune system process 9.83778742722768e-09 1617 144 40 0.277777777777778 0.0247371675943105
GO:BP GO:0002376 immune system process 1.1954157512205e-08 3278 146 60 0.410958904109589 0.0183038438071995
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 1.1954157512205e-08 122 129 12 0.0930232558139535 0.0983606557377049
GO:BP GO:0002706 regulation of lymphocyte mediated immunity 1.1954157512205e-08 151 129 13 0.10077519379845 0.0860927152317881
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 1.1954157512205e-08 177 9 6 0.666666666666667 0.0338983050847458
GO:BP GO:0050865 regulation of cell activation 1.31837129504067e-08 655 134 24 0.17910447761194 0.0366412213740458
GO:BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.34249443321455e-08 152 82 11 0.134146341463415 0.0723684210526316
GO:BP GO:0002449 lymphocyte mediated immunity 1.35564951659466e-08 354 85 15 0.176470588235294 0.0423728813559322
GO:BP GO:0001817 regulation of cytokine production 1.57843773448503e-08 806 131 26 0.198473282442748 0.032258064516129
GO:BP GO:0010033 response to organic substance 1.57843773448503e-08 3412 146 61 0.417808219178082 0.0178780773739742
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.68505052532485e-08 363 85 15 0.176470588235294 0.0413223140495868
GO:BP GO:0002819 regulation of adaptive immune response 2.96365587108118e-08 167 82 11 0.134146341463415 0.0658682634730539
GO:BP GO:0071310 cellular response to organic substance 4.37667381360393e-08 2776 146 53 0.363013698630137 0.0190922190201729
GO:BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5.2438698400378e-08 96 82 9 0.109756097560976 0.09375
GO:BP GO:1903131 mononuclear cell differentiation 5.2438698400378e-08 430 79 15 0.189873417721519 0.0348837209302326
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 5.2438698400378e-08 338 133 17 0.12781954887218 0.0502958579881657
GO:BP GO:0002440 production of molecular mediator of immune response 6.14092036971039e-08 189 79 11 0.139240506329114 0.0582010582010582
GO:BP GO:0002821 positive regulation of adaptive immune response 7.69825922781012e-08 101 82 9 0.109756097560976 0.0891089108910891
GO:BP GO:0002456 T cell mediated immunity 7.69825922781012e-08 98 85 9 0.105882352941176 0.0918367346938776
GO:BP GO:0030098 lymphocyte differentiation 7.69825922781012e-08 376 79 14 0.177215189873418 0.0372340425531915
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 8.10128905319551e-08 148 79 10 0.126582278481013 0.0675675675675676
GO:BP GO:0006955 immune response 1.06067132041144e-07 2311 85 33 0.388235294117647 0.0142795326698399
GO:BP GO:0002696 positive regulation of leukocyte activation 1.32322496380622e-07 412 134 18 0.134328358208955 0.0436893203883495
GO:BP GO:0071356 cellular response to tumor necrosis factor 1.52786324574225e-07 306 9 6 0.666666666666667 0.0196078431372549
GO:BP GO:0050867 positive regulation of cell activation 1.97296709721093e-07 424 134 18 0.134328358208955 0.0424528301886792
GO:BP GO:0002250 adaptive immune response 2.00793702612549e-07 689 85 18 0.211764705882353 0.0261248185776488
GO:BP GO:0070887 cellular response to chemical stimulus 2.06878929051297e-07 3393 146 58 0.397260273972603 0.0170940170940171
GO:BP GO:0034612 response to tumor necrosis factor 2.20904566701311e-07 331 9 6 0.666666666666667 0.0181268882175227
GO:BP GO:0002708 positive regulation of lymphocyte mediated immunity 2.63886834100113e-07 104 129 10 0.0775193798449612 0.0961538461538462
GO:BP GO:0042098 T cell proliferation 2.73067992237997e-07 205 133 13 0.0977443609022556 0.0634146341463415
GO:BP GO:0045785 positive regulation of cell adhesion 2.74786238834703e-07 437 18 8 0.444444444444444 0.0183066361556064
GO:BP GO:0002724 regulation of T cell cytokine production 2.9365713810091e-07 33 75 6 0.08 0.181818181818182
GO:BP GO:0002699 positive regulation of immune effector process 3.12045120864939e-07 215 129 13 0.10077519379845 0.0604651162790698
GO:BP GO:0002697 regulation of immune effector process 3.18370088960148e-07 461 129 18 0.13953488372093 0.0390455531453362
GO:BP GO:0012501 programmed cell death 3.28736489406997e-07 2143 134 41 0.305970149253731 0.0191320578628091
GO:BP GO:0050870 positive regulation of T cell activation 3.95627568396527e-07 219 85 11 0.129411764705882 0.0502283105022831
GO:BP GO:0042129 regulation of T cell proliferation 4.26338407549015e-07 176 133 12 0.0902255639097744 0.0681818181818182
GO:BP GO:0006915 apoptotic process 4.32574763891708e-07 1990 134 39 0.291044776119403 0.0195979899497487
GO:BP GO:0002369 T cell cytokine production 4.42550419972957e-07 36 75 6 0.08 0.166666666666667
GO:BP GO:0043067 regulation of programmed cell death 5.36515105962663e-07 1582 134 34 0.253731343283582 0.0214917825537295
GO:BP GO:0030217 T cell differentiation 5.51214982299038e-07 260 75 11 0.146666666666667 0.0423076923076923
GO:BP GO:0008219 cell death 6.22971394211975e-07 2292 134 42 0.313432835820896 0.0183246073298429
GO:BP GO:0002521 leukocyte differentiation 6.98039666929897e-07 550 79 15 0.189873417721519 0.0272727272727273
GO:BP GO:0051251 positive regulation of lymphocyte activation 6.98039666929897e-07 365 134 16 0.119402985074627 0.0438356164383562
GO:BP GO:0080134 regulation of response to stress 6.98039666929897e-07 1443 82 24 0.292682926829268 0.0166320166320166
GO:BP GO:0050670 regulation of lymphocyte proliferation 7.94270892834028e-07 230 133 13 0.0977443609022556 0.0565217391304348
GO:BP GO:0002517 T cell tolerance induction 8.44543079399421e-07 14 38 4 0.105263157894737 0.285714285714286
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 8.44543079399421e-07 241 85 11 0.129411764705882 0.045643153526971
GO:BP GO:0032944 regulation of mononuclear cell proliferation 8.44543079399421e-07 232 133 13 0.0977443609022556 0.0560344827586207
GO:BP GO:0048518 positive regulation of biological process 1.0613180795628e-06 6363 137 80 0.583941605839416 0.0125726858400126
GO:BP GO:0002709 regulation of T cell mediated immunity 1.11990301849779e-06 74 75 7 0.0933333333333333 0.0945945945945946
GO:BP GO:0022407 regulation of cell-cell adhesion 1.40298782154859e-06 445 133 17 0.12781954887218 0.0382022471910112
GO:BP GO:0007166 cell surface receptor signaling pathway 1.4504698196677e-06 3210 10 10 1 0.00311526479750779
GO:BP GO:0045589 regulation of regulatory T cell differentiation 1.66037737485178e-06 35 18 4 0.222222222222222 0.114285714285714
GO:BP GO:0070663 regulation of leukocyte proliferation 1.94024963320643e-06 251 133 13 0.0977443609022556 0.051792828685259
GO:BP GO:0009893 positive regulation of metabolic process 1.95485552369661e-06 3783 135 56 0.414814814814815 0.0148030663494581
GO:BP GO:0002252 immune effector process 1.95485552369661e-06 1309 146 31 0.212328767123288 0.0236822001527884
GO:BP GO:0002711 positive regulation of T cell mediated immunity 1.96349328671797e-06 48 75 6 0.08 0.125
GO:BP GO:1902105 regulation of leukocyte differentiation 2.06994342470615e-06 288 79 11 0.139240506329114 0.0381944444444444
GO:BP GO:0042981 regulation of apoptotic process 2.11272543486307e-06 1549 82 24 0.292682926829268 0.0154938670109748
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 2.11272543486307e-06 3483 135 53 0.392592592592593 0.0152167671547517
GO:BP GO:0045066 regulatory T cell differentiation 2.11272543486307e-06 38 18 4 0.222222222222222 0.105263157894737
GO:BP GO:0048522 positive regulation of cellular process 2.27719097175524e-06 5757 137 74 0.54014598540146 0.0128539169706444
GO:BP GO:0002718 regulation of cytokine production involved in immune response 2.46231936817792e-06 85 75 7 0.0933333333333333 0.0823529411764706
GO:BP GO:0002684 positive regulation of immune system process 2.47813502865272e-06 1065 134 26 0.194029850746269 0.0244131455399061
GO:BP GO:0010941 regulation of cell death 2.84471618592454e-06 1720 134 34 0.253731343283582 0.0197674418604651
GO:BP GO:0022409 positive regulation of cell-cell adhesion 3.46554166454208e-06 284 85 11 0.129411764705882 0.0387323943661972
GO:BP GO:0045619 regulation of lymphocyte differentiation 3.46554166454208e-06 180 79 9 0.113924050632911 0.05
GO:BP GO:0002520 immune system development 3.99384659134767e-06 1020 82 19 0.231707317073171 0.0186274509803922
GO:BP GO:0001819 positive regulation of cytokine production 4.35957524427528e-06 452 82 13 0.158536585365854 0.0287610619469027
GO:BP GO:0002367 cytokine production involved in immune response 4.54423715252258e-06 94 75 7 0.0933333333333333 0.074468085106383
GO:BP GO:0002443 leukocyte mediated immunity 5.12076259100713e-06 877 146 24 0.164383561643836 0.0273660205245154
GO:BP GO:0050727 regulation of inflammatory response 5.12076259100713e-06 381 82 12 0.146341463414634 0.031496062992126
GO:BP GO:0045580 regulation of T cell differentiation 5.66108184368859e-06 152 72 8 0.111111111111111 0.0526315789473684
GO:BP GO:0002702 positive regulation of production of molecular mediator of immune response 6.65099557246635e-06 100 75 7 0.0933333333333333 0.07
GO:BP GO:0048523 negative regulation of cellular process 7.3462202601205e-06 5139 83 46 0.55421686746988 0.00895115781280405
GO:BP GO:0048534 hematopoietic or lymphoid organ development 8.39011864756078e-06 966 82 18 0.219512195121951 0.0186335403726708
GO:BP GO:0006952 defense response 8.40728983699801e-06 1818 82 25 0.304878048780488 0.0137513751375138
GO:BP GO:0007155 cell adhesion 8.41332066085194e-06 1492 146 32 0.219178082191781 0.0214477211796247
GO:BP GO:0030155 regulation of cell adhesion 8.41332066085194e-06 748 18 8 0.444444444444444 0.0106951871657754
GO:BP GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent 8.73952962232229e-06 8 144 4 0.0277777777777778 0.5
GO:BP GO:0046651 lymphocyte proliferation 8.73952962232229e-06 294 133 13 0.0977443609022556 0.0442176870748299
GO:BP GO:0022610 biological adhesion 8.95944686073157e-06 1499 146 32 0.219178082191781 0.0213475650433622
GO:BP GO:1903706 regulation of hemopoiesis 9.4014986238759e-06 424 79 12 0.151898734177215 0.0283018867924528
GO:BP GO:0032943 mononuclear cell proliferation 9.40721191022032e-06 297 18 6 0.333333333333333 0.0202020202020202
GO:BP GO:0002507 tolerance induction 1.19509848070359e-05 29 38 4 0.105263157894737 0.137931034482759
GO:BP GO:0050776 regulation of immune response 1.19509848070359e-05 996 82 18 0.219512195121951 0.0180722891566265
GO:BP GO:0070661 leukocyte proliferation 1.51893304802441e-05 325 18 6 0.333333333333333 0.0184615384615385
GO:BP GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent 1.51893304802441e-05 3 144 3 0.0208333333333333 1
GO:BP GO:0002484 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway 1.51893304802441e-05 3 144 3 0.0208333333333333 1
GO:BP GO:0031347 regulation of defense response 1.62012201275727e-05 704 82 15 0.182926829268293 0.0213068181818182
GO:BP GO:0048584 positive regulation of response to stimulus 1.73185499544113e-05 2344 134 39 0.291044776119403 0.0166382252559727
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.96493547803992e-05 217 83 9 0.108433734939759 0.0414746543778802
GO:BP GO:0042270 protection from natural killer cell mediated cytotoxicity 2.23267980766598e-05 6 62 3 0.0483870967741935 0.5
GO:BP GO:0045058 T cell selection 2.23267980766598e-05 51 61 5 0.0819672131147541 0.0980392156862745
GO:BP GO:0098609 cell-cell adhesion 2.23267980766598e-05 894 146 23 0.157534246575342 0.0257270693512304
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 2.4756740719579e-05 141 131 9 0.0687022900763359 0.0638297872340425
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 2.60353915652076e-05 142 131 9 0.0687022900763359 0.0633802816901408
GO:BP GO:0042113 B cell activation 2.97752368289229e-05 330 134 13 0.0970149253731343 0.0393939393939394
GO:BP GO:0002707 negative regulation of lymphocyte mediated immunity 3.29542329012011e-05 43 79 5 0.0632911392405063 0.116279069767442
GO:BP GO:0031348 negative regulation of defense response 3.39916670625038e-05 246 79 9 0.113924050632911 0.0365853658536585
GO:BP GO:0002726 positive regulation of T cell cytokine production 3.44677573451498e-05 20 75 4 0.0533333333333333 0.2
GO:BP GO:0032655 regulation of interleukin-12 production 3.65411036200074e-05 60 58 5 0.0862068965517241 0.0833333333333333
GO:BP GO:0032615 interleukin-12 production 3.65411036200074e-05 60 58 5 0.0862068965517241 0.0833333333333333
GO:BP GO:0030162 regulation of proteolysis 3.83737732239241e-05 752 83 15 0.180722891566265 0.0199468085106383
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 4.04637770906182e-05 240 83 9 0.108433734939759 0.0375
GO:BP GO:0042221 response to chemical 4.26564031534786e-05 4781 146 65 0.445205479452055 0.013595482116712
GO:BP GO:0002664 regulation of T cell tolerance induction 4.85234350274016e-05 12 38 3 0.0789473684210526 0.25
GO:BP GO:0032663 regulation of interleukin-2 production 4.88332667072929e-05 61 61 5 0.0819672131147541 0.0819672131147541
GO:BP GO:0070665 positive regulation of leukocyte proliferation 4.88332667072929e-05 155 131 9 0.0687022900763359 0.0580645161290323
GO:BP GO:0030097 hemopoiesis 5.20917282661525e-05 928 79 16 0.20253164556962 0.0172413793103448
GO:BP GO:1902533 positive regulation of intracellular signal transduction 5.25572943016904e-05 1037 134 23 0.171641791044776 0.0221793635486982
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 5.2695755037533e-05 2255 75 25 0.333333333333333 0.0110864745011086
GO:BP GO:0032623 interleukin-2 production 5.539507318295e-05 63 61 5 0.0819672131147541 0.0793650793650794
GO:BP GO:0006954 inflammatory response 5.90234933970524e-05 794 82 15 0.182926829268293 0.0188916876574307
GO:BP GO:0048519 negative regulation of biological process 6.06346896586213e-05 5757 83 47 0.566265060240964 0.00816397429216606
GO:BP GO:0043029 T cell homeostasis 6.07868112816374e-05 40 99 5 0.0505050505050505 0.125
GO:BP GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I 6.27620286046671e-05 13 144 4 0.0277777777777778 0.307692307692308
GO:BP GO:0010628 positive regulation of gene expression 6.39154499348334e-05 1160 131 24 0.183206106870229 0.0206896551724138
GO:BP GO:0060548 negative regulation of cell death 6.39944872973244e-05 1038 81 17 0.209876543209877 0.0163776493256262
GO:BP GO:0002704 negative regulation of leukocyte mediated immunity 6.59948734606373e-05 51 79 5 0.0632911392405063 0.0980392156862745
GO:BP GO:0002720 positive regulation of cytokine production involved in immune response 6.7456136112382e-05 54 75 5 0.0666666666666667 0.0925925925925926
GO:BP GO:0043068 positive regulation of programmed cell death 7.61183942488198e-05 621 93 14 0.150537634408602 0.0225442834138486
GO:BP GO:0031341 regulation of cell killing 8.44400031154507e-05 93 125 7 0.056 0.0752688172043011
GO:BP GO:0009967 positive regulation of signal transduction 0.000105041818537132 1598 134 29 0.216417910447761 0.0181476846057572
GO:BP GO:0007165 signal transduction 0.000120893952339069 6309 134 72 0.537313432835821 0.0114122681883024
GO:BP GO:0050777 negative regulation of immune response 0.000125135880942232 157 79 7 0.0886075949367089 0.0445859872611465
GO:BP GO:0002643 regulation of tolerance induction 0.000153111803595126 18 38 3 0.0789473684210526 0.166666666666667
GO:BP GO:0007154 cell communication 0.000173770590561662 6829 99 59 0.595959595959596 0.00863962512813003
GO:BP GO:0006950 response to stress 0.000175036201566825 4170 88 39 0.443181818181818 0.00935251798561151
GO:BP GO:0042102 positive regulation of T cell proliferation 0.000206748493649087 104 85 6 0.0705882352941176 0.0576923076923077
GO:BP GO:0032673 regulation of interleukin-4 production 0.000211011057172262 31 79 4 0.0506329113924051 0.129032258064516
GO:BP GO:0010942 positive regulation of cell death 0.000213945971094675 684 93 14 0.150537634408602 0.0204678362573099
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.000216944976258164 142 133 8 0.0601503759398496 0.0563380281690141
GO:BP GO:0032102 negative regulation of response to external stimulus 0.000222875478638531 406 79 10 0.126582278481013 0.0246305418719212
GO:BP GO:0032649 regulation of interferon-gamma production 0.000224089019159194 110 82 6 0.0731707317073171 0.0545454545454545
GO:BP GO:0032633 interleukin-4 production 0.000232346732017638 32 79 4 0.0506329113924051 0.125
GO:BP GO:0051239 regulation of multicellular organismal process 0.00023328306587482 2861 82 29 0.353658536585366 0.0101363159734359
GO:BP GO:0043066 negative regulation of apoptotic process 0.000254869318543931 921 81 15 0.185185185185185 0.0162866449511401
GO:BP GO:0042130 negative regulation of T cell proliferation 0.000258815480922274 70 133 6 0.0451127819548872 0.0857142857142857
GO:BP GO:0002483 antigen processing and presentation of endogenous peptide antigen 0.000277951358261361 19 144 4 0.0277777777777778 0.210526315789474
GO:BP GO:0032609 interferon-gamma production 0.000277951358261361 115 82 6 0.0731707317073171 0.0521739130434783
GO:BP GO:0050864 regulation of B cell activation 0.000288613811310015 194 134 9 0.0671641791044776 0.0463917525773196
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.000290786901123823 3274 135 45 0.333333333333333 0.0137446548564447
GO:BP GO:0043069 negative regulation of programmed cell death 0.000324080754270497 943 81 15 0.185185185185185 0.0159066808059385
GO:BP GO:0032101 regulation of response to external stimulus 0.000326523599769268 1051 82 16 0.195121951219512 0.0152235965746908
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.000337813248398415 3083 135 43 0.318518518518519 0.0139474537787869
GO:BP GO:0023052 signaling 0.000341821697622503 6810 99 58 0.585858585858586 0.00851688693098385
GO:BP GO:0002698 negative regulation of immune effector process 0.000342346667085087 125 79 6 0.0759493670886076 0.048
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.000342346667085087 251 134 10 0.0746268656716418 0.0398406374501992
GO:BP GO:0032874 positive regulation of stress-activated MAPK cascade 0.000342346667085087 121 122 7 0.0573770491803279 0.0578512396694215
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00036606316044867 717 146 18 0.123287671232877 0.0251046025104603
GO:BP GO:0050868 negative regulation of T cell activation 0.000369237042521582 123 24 4 0.166666666666667 0.032520325203252
GO:BP GO:0009605 response to external stimulus 0.000369237042521582 2944 82 29 0.353658536585366 0.00985054347826087
GO:BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 0.000371788215841507 123 122 7 0.0573770491803279 0.0569105691056911
GO:BP GO:0002260 lymphocyte homeostasis 0.000383830866485615 61 99 5 0.0505050505050505 0.0819672131147541
GO:BP GO:0002263 cell activation involved in immune response 0.000383830866485615 721 146 18 0.123287671232877 0.0249653259361997
GO:BP GO:0045953 negative regulation of natural killer cell mediated cytotoxicity 0.00038455575687877 16 62 3 0.0483870967741935 0.1875
GO:BP GO:0048302 regulation of isotype switching to IgG isotypes 0.000408134320212241 13 79 3 0.0379746835443038 0.230769230769231
GO:BP GO:0051247 positive regulation of protein metabolic process 0.000408134320212241 1564 133 27 0.203007518796992 0.0172634271099744
GO:BP GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 0.000409319025723695 48 129 5 0.0387596899224806 0.104166666666667
GO:BP GO:0045190 isotype switching 0.000409319025723695 48 129 5 0.0387596899224806 0.104166666666667
GO:BP GO:0002208 somatic diversification of immunoglobulins involved in immune response 0.000409319025723695 48 129 5 0.0387596899224806 0.104166666666667
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.00041769680989933 1477 133 26 0.195488721804511 0.017603249830738
GO:BP GO:0051707 response to other organism 0.000431291609881066 1592 146 29 0.198630136986301 0.01821608040201
GO:BP GO:0044068 modulation by symbiont of host cellular process 0.000433241870779983 25 125 4 0.032 0.16
GO:BP GO:0043207 response to external biotic stimulus 0.000436552117391011 1594 146 29 0.198630136986301 0.0181932245922208
GO:BP GO:0002716 negative regulation of natural killer cell mediated immunity 0.000440085618024642 17 62 3 0.0483870967741935 0.176470588235294
GO:BP GO:0051716 cellular response to stimulus 0.000451863247821009 7781 99 63 0.636363636363636 0.00809664567536306
GO:BP GO:0001913 T cell mediated cytotoxicity 0.000467060189794117 42 75 4 0.0533333333333333 0.0952380952380952
GO:BP GO:0048291 isotype switching to IgG isotypes 0.000484334832409744 14 79 3 0.0379746835443038 0.214285714285714
GO:BP GO:0001906 cell killing 0.000496782421128046 175 125 8 0.064 0.0457142857142857
GO:BP GO:0098543 detection of other organism 0.000496782421128046 19 58 3 0.0517241379310345 0.157894736842105
GO:BP GO:0052548 regulation of endopeptidase activity 0.000510559575763136 437 83 10 0.120481927710843 0.022883295194508
GO:BP GO:0031343 positive regulation of cell killing 0.000510559575763136 59 111 5 0.045045045045045 0.0847457627118644
GO:BP GO:0045582 positive regulation of T cell differentiation 0.000513304100896497 91 72 5 0.0694444444444444 0.0549450549450549
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 0.000529447032901324 88 75 5 0.0666666666666667 0.0568181818181818
GO:BP GO:0035556 intracellular signal transduction 0.000563420306086997 2772 134 39 0.291044776119403 0.0140692640692641
GO:BP GO:0010647 positive regulation of cell communication 0.000565556724845055 1777 134 29 0.216417910447761 0.0163196398424311
GO:BP GO:0051403 stress-activated MAPK cascade 0.000574359487988942 272 134 10 0.0746268656716418 0.0367647058823529
GO:BP GO:0009607 response to biotic stimulus 0.000581278003892652 1626 146 29 0.198630136986301 0.0178351783517835
GO:BP GO:0023056 positive regulation of signaling 0.000586438086503396 1782 134 29 0.216417910447761 0.0162738496071829
GO:BP GO:0002381 immunoglobulin production involved in immunoglobulin-mediated immune response 0.00059566997627135 53 129 5 0.0387596899224806 0.0943396226415094
GO:BP GO:1903708 positive regulation of hemopoiesis 0.000598701472310486 157 72 6 0.0833333333333333 0.0382165605095541
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.000598701472310486 157 72 6 0.0833333333333333 0.0382165605095541
GO:BP GO:0050672 negative regulation of lymphocyte proliferation 0.000603656309886335 85 133 6 0.0451127819548872 0.0705882352941176
GO:BP GO:0048583 regulation of response to stimulus 0.000623242651791348 4278 82 36 0.439024390243902 0.00841514726507714
GO:BP GO:0032501 multicellular organismal process 0.000623242651791348 7946 16 15 0.9375 0.00188774226025673
GO:BP GO:0002889 regulation of immunoglobulin mediated immune response 0.000623242651791348 54 129 5 0.0387596899224806 0.0925925925925926
GO:BP GO:0002712 regulation of B cell mediated immunity 0.000623242651791348 54 129 5 0.0387596899224806 0.0925925925925926
GO:BP GO:0032945 negative regulation of mononuclear cell proliferation 0.000623242651791348 86 133 6 0.0451127819548872 0.0697674418604651
GO:BP GO:0016447 somatic recombination of immunoglobulin gene segments 0.000623242651791348 54 129 5 0.0387596899224806 0.0925925925925926
GO:BP GO:0032653 regulation of interleukin-10 production 0.000623242651791348 60 58 4 0.0689655172413793 0.0666666666666667
GO:BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.000623844392961251 138 83 6 0.072289156626506 0.0434782608695652
GO:BP GO:0001911 negative regulation of leukocyte mediated cytotoxicity 0.000634285067233309 20 62 3 0.0483870967741935 0.15
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.000635759489893647 1455 10 6 0.6 0.00412371134020619
GO:BP GO:0032872 regulation of stress-activated MAPK cascade 0.00066041178862005 190 122 8 0.0655737704918033 0.0421052631578947
GO:BP GO:0032613 interleukin-10 production 0.000688107607322322 62 58 4 0.0689655172413793 0.0645161290322581
GO:BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 0.000729336828786827 193 122 8 0.0655737704918033 0.0414507772020725
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.000729336828786827 156 24 4 0.166666666666667 0.0256410256410256
GO:BP GO:0019883 antigen processing and presentation of endogenous antigen 0.000737836481105743 26 144 4 0.0277777777777778 0.153846153846154
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.000742468928873071 107 111 6 0.0540540540540541 0.0560747663551402
GO:BP GO:0019222 regulation of metabolic process 0.000770623502252762 7148 135 76 0.562962962962963 0.0106323447118075
GO:BP GO:0052547 regulation of peptidase activity 0.000774750317115152 467 83 10 0.120481927710843 0.0214132762312634
GO:BP GO:0031098 stress-activated protein kinase signaling cascade 0.00081960458677448 288 134 10 0.0746268656716418 0.0347222222222222
GO:BP GO:0045862 positive regulation of proteolysis 0.000825119262608289 378 83 9 0.108433734939759 0.0238095238095238
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.000825119262608289 6603 83 48 0.578313253012048 0.0072694229895502
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 0.000830959712378312 104 72 5 0.0694444444444444 0.0480769230769231
GO:BP GO:0070664 negative regulation of leukocyte proliferation 0.000842695065550685 92 133 6 0.0451127819548872 0.0652173913043478
GO:BP GO:0098581 detection of external biotic stimulus 0.000844338442905979 24 58 3 0.0517241379310345 0.125
GO:BP GO:0043065 positive regulation of apoptotic process 0.000844338442905979 604 93 12 0.129032258064516 0.0198675496688742
GO:BP GO:0050852 T cell receptor signaling pathway 0.000855013358243831 203 61 6 0.0983606557377049 0.0295566502463054
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.000862381148244111 291 134 10 0.0746268656716418 0.0343642611683849
GO:BP GO:2000026 regulation of multicellular organismal development 0.000920351503008077 1447 82 18 0.219512195121951 0.0124395300621977
GO:BP GO:0042832 defense response to protozoan 0.000940646930984646 25 58 3 0.0517241379310345 0.12
GO:BP GO:0032753 positive regulation of interleukin-4 production 0.000960998738254379 24 61 3 0.0491803278688525 0.125
GO:BP GO:0016445 somatic diversification of immunoglobulins 0.00100032492506582 61 129 5 0.0387596899224806 0.0819672131147541
GO:BP GO:0031342 negative regulation of cell killing 0.00100032492506582 24 62 3 0.0483870967741935 0.125
GO:BP GO:0065009 regulation of molecular function 0.00102142046046262 3221 133 42 0.315789473684211 0.0130394287488358
GO:BP GO:0042127 regulation of cell population proliferation 0.00102142046046262 1774 133 28 0.210526315789474 0.0157835400225479
GO:BP GO:0002320 lymphoid progenitor cell differentiation 0.00102142046046262 21 72 3 0.0416666666666667 0.142857142857143
GO:BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.00102142046046262 154 83 6 0.072289156626506 0.038961038961039
GO:BP GO:0001562 response to protozoan 0.00102526301664327 26 58 3 0.0517241379310345 0.115384615384615
GO:BP GO:0009615 response to virus 0.00105701527630319 364 23 5 0.217391304347826 0.0137362637362637
GO:BP GO:0051246 regulation of protein metabolic process 0.00116323799787104 2704 133 37 0.278195488721804 0.0136834319526627
GO:BP GO:0001910 regulation of leukocyte mediated cytotoxicity 0.00117628248440001 74 111 5 0.045045045045045 0.0675675675675676
GO:BP GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 0.00118098097677476 64 129 5 0.0387596899224806 0.078125
GO:BP GO:0048872 homeostasis of number of cells 0.00118098097677476 261 99 8 0.0808080808080808 0.0306513409961686
GO:BP GO:0016444 somatic cell DNA recombination 0.00118098097677476 64 129 5 0.0387596899224806 0.078125
GO:BP GO:0019724 B cell mediated immunity 0.00118146429157375 226 85 7 0.0823529411764706 0.0309734513274336
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.00118934860620603 194 133 8 0.0601503759398496 0.0412371134020619
GO:BP GO:0050728 negative regulation of inflammatory response 0.00128330501685421 171 79 6 0.0759493670886076 0.0350877192982456
GO:BP GO:0002695 negative regulation of leukocyte activation 0.00128330501685421 188 24 4 0.166666666666667 0.0212765957446809
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00128708885743831 323 61 7 0.114754098360656 0.021671826625387
GO:BP GO:0045191 regulation of isotype switching 0.00134401553199469 35 129 4 0.0310077519379845 0.114285714285714
GO:BP GO:0001776 leukocyte homeostasis 0.00134401553199469 86 99 5 0.0505050505050505 0.0581395348837209
GO:BP GO:0048585 negative regulation of response to stimulus 0.00134401553199469 1733 91 21 0.230769230769231 0.0121177149451818
GO:BP GO:0042269 regulation of natural killer cell mediated cytotoxicity 0.00140244402228999 41 111 4 0.036036036036036 0.0975609756097561
GO:BP GO:0002637 regulation of immunoglobulin production 0.00141362759697632 67 129 5 0.0387596899224806 0.0746268656716418
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.00145097894849972 2541 83 25 0.301204819277108 0.00983864620228257
GO:BP GO:0032743 positive regulation of interleukin-2 production 0.00176613167148539 32 58 3 0.0517241379310345 0.09375
GO:BP GO:0044003 modulation by symbiont of host process 0.00179298437410694 39 125 4 0.032 0.102564102564103
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 0.00181882239325737 110 83 5 0.0602409638554217 0.0454545454545455
GO:BP GO:0050866 negative regulation of cell activation 0.00190388711165653 211 24 4 0.166666666666667 0.018957345971564
GO:BP GO:0002200 somatic diversification of immune receptors 0.00193810666958786 72 129 5 0.0387596899224806 0.0694444444444444
GO:BP GO:0002715 regulation of natural killer cell mediated immunity 0.00195635850292044 45 111 4 0.036036036036036 0.0888888888888889
GO:BP GO:0001916 positive regulation of T cell mediated cytotoxicity 0.00196788935872484 26 75 3 0.04 0.115384615384615
GO:BP GO:0051709 regulation of killing of cells of other organism 0.00199270602448254 16 125 3 0.024 0.1875
GO:BP GO:0046631 alpha-beta T cell activation 0.00205142818568936 155 61 5 0.0819672131147541 0.032258064516129
GO:BP GO:0044093 positive regulation of molecular function 0.00217364474852763 1771 133 27 0.203007518796992 0.0152456239412761
GO:BP GO:1903317 regulation of protein maturation 0.00221052803544889 68 76 4 0.0526315789473684 0.0588235294117647
GO:BP GO:0002683 negative regulation of immune system process 0.0022382622415848 420 24 5 0.208333333333333 0.0119047619047619
GO:BP GO:0050778 positive regulation of immune response 0.00234929927863134 753 111 14 0.126126126126126 0.0185922974767596
GO:BP GO:0009595 detection of biotic stimulus 0.00235624763664325 36 58 3 0.0517241379310345 0.0833333333333333
GO:BP GO:0002437 inflammatory response to antigenic stimulus 0.00243533507293288 65 82 4 0.0487804878048781 0.0615384615384615
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.00243648035039794 1001 75 13 0.173333333333333 0.012987012987013
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.00246368168178236 187 83 6 0.072289156626506 0.0320855614973262
GO:BP GO:0032729 positive regulation of interferon-gamma production 0.00255609317541805 66 82 4 0.0487804878048781 0.0606060606060606
GO:BP GO:0050690 regulation of defense response to virus by virus 0.00258610136477423 29 75 3 0.04 0.103448275862069
GO:BP GO:0097191 extrinsic apoptotic signaling pathway 0.00258813350172206 223 132 8 0.0606060606060606 0.0358744394618834
GO:BP GO:0008283 cell population proliferation 0.00265688013317461 2054 142 31 0.21830985915493 0.0150925024342746
GO:BP GO:0032733 positive regulation of interleukin-10 production 0.00269379845488339 38 58 3 0.0517241379310345 0.0789473684210526
GO:BP GO:0002312 B cell activation involved in immune response 0.00277038584064811 79 129 5 0.0387596899224806 0.0632911392405063
GO:BP GO:0001818 negative regulation of cytokine production 0.00278273483168882 381 79 8 0.10126582278481 0.020997375328084
GO:BP GO:0001912 positive regulation of leukocyte mediated cytotoxicity 0.00293607821454414 51 111 4 0.036036036036036 0.0784313725490196
GO:BP GO:0033077 T cell differentiation in thymus 0.00303769499812909 76 75 4 0.0533333333333333 0.0526315789473684
GO:BP GO:0046330 positive regulation of JNK cascade 0.00311503469543809 86 122 5 0.040983606557377 0.0581395348837209
GO:BP GO:1903318 negative regulation of protein maturation 0.00314417869565094 31 76 3 0.0394736842105263 0.0967741935483871
GO:BP GO:0010955 negative regulation of protein processing 0.00314417869565094 31 76 3 0.0394736842105263 0.0967741935483871
GO:BP GO:0010468 regulation of gene expression 0.00320394723881897 5196 83 39 0.469879518072289 0.00750577367205543
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 0.00345815631906677 75 144 5 0.0347222222222222 0.0666666666666667
GO:BP GO:0097190 apoptotic signaling pathway 0.00347446445910535 600 96 11 0.114583333333333 0.0183333333333333
GO:BP GO:2000758 positive regulation of peptidyl-lysine acetylation 0.00347446445910535 34 72 3 0.0416666666666667 0.0882352941176471
GO:BP GO:0098542 defense response to other organism 0.00348222694301524 1218 82 15 0.182926829268293 0.0123152709359606
GO:BP GO:0010952 positive regulation of peptidase activity 0.00372954375447321 205 83 6 0.072289156626506 0.0292682926829268
GO:BP GO:0006508 proteolysis 0.00391644919266951 1836 134 27 0.201492537313433 0.0147058823529412
GO:BP GO:0050896 response to stimulus 0.00391644919266951 9407 100 69 0.69 0.00733496332518337
GO:BP GO:0046634 regulation of alpha-beta T cell activation 0.00393197407232996 102 61 4 0.0655737704918033 0.0392156862745098
GO:BP GO:0042770 signal transduction in response to DNA damage 0.00393197407232996 135 83 5 0.0602409638554217 0.037037037037037
GO:BP GO:0002832 negative regulation of response to biotic stimulus 0.00393197407232996 100 62 4 0.0645161290322581 0.04
GO:BP GO:0032675 regulation of interleukin-6 production 0.00395464268787652 168 67 5 0.0746268656716418 0.0297619047619048
GO:BP GO:0001914 regulation of T cell mediated cytotoxicity 0.00406723642474909 35 75 3 0.04 0.0857142857142857
GO:BP GO:0140352 export from cell 0.00406723642474909 1418 146 24 0.164383561643836 0.0169252468265162
GO:BP GO:0045595 regulation of cell differentiation 0.0042567390231997 1679 82 18 0.219512195121951 0.0107206670637284
GO:BP GO:0050869 negative regulation of B cell activation 0.00429955054703439 34 79 3 0.0379746835443038 0.0882352941176471
GO:BP GO:0032635 interleukin-6 production 0.00430863470397269 172 67 5 0.0746268656716418 0.0290697674418605
GO:BP GO:1990830 cellular response to leukemia inhibitory factor 0.00430863470397269 89 129 5 0.0387596899224806 0.0561797752808989
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 0.0043339946844524 80 144 5 0.0347222222222222 0.0625
GO:BP GO:0032502 developmental process 0.00434637122440662 6628 18 14 0.777777777777778 0.00211225105612553
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.00444200698660928 185 134 7 0.0522388059701493 0.0378378378378378
GO:BP GO:0016032 viral process 0.00445379173379489 942 75 12 0.16 0.0127388535031847
GO:BP GO:1990823 response to leukemia inhibitory factor 0.00445379173379489 90 129 5 0.0387596899224806 0.0555555555555556
GO:BP GO:0008285 negative regulation of cell population proliferation 0.00454510600559585 790 142 16 0.112676056338028 0.020253164556962
GO:BP GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.00455768099494684 81 81 4 0.0493827160493827 0.0493827160493827
GO:BP GO:0016064 immunoglobulin mediated immune response 0.00494494692159013 223 82 6 0.0731707317073171 0.0269058295964126
GO:BP GO:0071346 cellular response to interferon-gamma 0.00512322367554223 175 146 7 0.0479452054794521 0.04
GO:BP GO:0031295 T cell costimulation 0.00512322367554223 58 50 3 0.06 0.0517241379310345
GO:BP GO:0042092 type 2 immune response 0.00515969860303758 37 79 3 0.0379746835443038 0.0810810810810811
GO:BP GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 0.00520321229921072 92 132 5 0.0378787878787879 0.0543478260869565
GO:BP GO:0042267 natural killer cell mediated cytotoxicity 0.0052137483898964 62 111 4 0.036036036036036 0.0645161290322581
GO:BP GO:0032940 secretion by cell 0.00523773839873272 1364 146 23 0.157534246575342 0.0168621700879765
GO:BP GO:0032879 regulation of localization 0.00543005259811829 2872 142 38 0.267605633802817 0.0132311977715877
GO:BP GO:0031294 lymphocyte costimulation 0.00546815325278599 60 50 3 0.06 0.05
GO:BP GO:0008284 positive regulation of cell population proliferation 0.00558772409642439 982 85 13 0.152941176470588 0.0132382892057026
GO:BP GO:0007162 negative regulation of cell adhesion 0.00560487957777656 304 24 4 0.166666666666667 0.0131578947368421
GO:BP GO:0050794 regulation of cellular process 0.00583708934707575 11473 99 78 0.787878787878788 0.00679857055695982
GO:BP GO:2000117 negative regulation of cysteine-type endopeptidase activity 0.00592004788715165 89 81 4 0.0493827160493827 0.0449438202247191
GO:BP GO:0002228 natural killer cell mediated immunity 0.00592004788715165 65 111 4 0.036036036036036 0.0615384615384615
GO:BP GO:0048731 system development 0.00601914914108526 5052 18 12 0.666666666666667 0.00237529691211401
GO:BP GO:0042100 B cell proliferation 0.00626815690144557 98 131 5 0.0381679389312977 0.0510204081632653
GO:BP GO:1901985 positive regulation of protein acetylation 0.00690002481805622 46 72 3 0.0416666666666667 0.0652173913043478
GO:BP GO:0046635 positive regulation of alpha-beta T cell activation 0.00712493011142985 67 50 3 0.06 0.0447761194029851
GO:BP GO:0031401 positive regulation of protein modification process 0.00736593770405563 1074 133 18 0.135338345864662 0.0167597765363128
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.00738344378784474 253 14 3 0.214285714285714 0.0118577075098814
GO:BP GO:0044267 cellular protein metabolic process 0.00752049833521953 5229 134 56 0.417910447761194 0.0107095046854083
GO:BP GO:0050871 positive regulation of B cell activation 0.0075839879516132 151 134 6 0.0447761194029851 0.0397350993377483
GO:BP GO:0046903 secretion 0.00759059506548417 1501 146 24 0.164383561643836 0.0159893404397069
GO:BP GO:1902531 regulation of intracellular signal transduction 0.00759361726607923 1842 134 26 0.194029850746269 0.0141150922909881
GO:BP GO:0048856 anatomical structure development 0.00789794279637682 6106 18 13 0.722222222222222 0.00212905339010809
GO:BP GO:0050793 regulation of developmental process 0.0079033354199806 2605 82 23 0.280487804878049 0.00882917466410749
GO:BP GO:0006887 exocytosis 0.00815104434406217 904 146 17 0.116438356164384 0.0188053097345133
GO:BP GO:0002274 myeloid leukocyte activation 0.00825942061589515 667 146 14 0.0958904109589041 0.0209895052473763
GO:BP GO:0010466 negative regulation of peptidase activity 0.00836141937025822 267 14 3 0.214285714285714 0.0112359550561798
GO:BP GO:0051701 biological process involved in interaction with host 0.00845805679774755 221 129 7 0.0542635658914729 0.0316742081447964
GO:BP GO:0034341 response to interferon-gamma 0.00861895160115865 196 146 7 0.0479452054794521 0.0357142857142857
GO:BP GO:0002757 immune response-activating signal transduction 0.0086237321598098 477 61 7 0.114754098360656 0.0146750524109015
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0086237321598098 477 61 7 0.114754098360656 0.0146750524109015
GO:BP GO:0030888 regulation of B cell proliferation 0.00888820065786979 63 131 4 0.0305343511450382 0.0634920634920635
GO:BP GO:0045861 negative regulation of proteolysis 0.00888820065786979 359 81 7 0.0864197530864197 0.0194986072423398
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 0.00916260816645849 99 144 5 0.0347222222222222 0.0505050505050505
GO:BP GO:0002831 regulation of response to biotic stimulus 0.00981526825738633 415 10 3 0.3 0.0072289156626506
GO:BP GO:0071479 cellular response to ionizing radiation 0.0101098403104712 69 125 4 0.032 0.0579710144927536
GO:BP GO:0031571 mitotic G1 DNA damage checkpoint 0.0104220947409477 66 132 4 0.0303030303030303 0.0606060606060606
GO:BP GO:0060337 type I interferon signaling pathway 0.0105054693812582 95 42 3 0.0714285714285714 0.0315789473684211
GO:BP GO:0071357 cellular response to type I interferon 0.0108011112618329 96 42 3 0.0714285714285714 0.03125
GO:BP GO:0042093 T-helper cell differentiation 0.0108074095067689 66 61 3 0.0491803278688525 0.0454545454545455
GO:BP GO:0044783 G1 DNA damage checkpoint 0.0108224008343676 67 132 4 0.0303030303030303 0.0597014925373134
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0108224008343676 1160 79 13 0.164556962025316 0.0112068965517241
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.0108224008343676 190 79 5 0.0632911392405063 0.0263157894736842
GO:BP GO:0044819 mitotic G1/S transition checkpoint 0.0108224008343676 67 132 4 0.0303030303030303 0.0597014925373134
GO:BP GO:0045824 negative regulation of innate immune response 0.0111680020155367 66 62 3 0.0483870967741935 0.0454545454545455
GO:BP GO:0002294 CD4-positive, alpha-beta T cell differentiation involved in immune response 0.0115058942183828 68 61 3 0.0491803278688525 0.0441176470588235
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.0118760316302295 512 61 7 0.114754098360656 0.013671875
GO:BP GO:0002293 alpha-beta T cell differentiation involved in immune response 0.0119170856425467 69 61 3 0.0491803278688525 0.0434782608695652
GO:BP GO:0002287 alpha-beta T cell activation involved in immune response 0.0119170856425467 69 61 3 0.0491803278688525 0.0434782608695652
GO:BP GO:0034340 response to type I interferon 0.012028687673975 101 42 3 0.0714285714285714 0.0297029702970297
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0120543898257879 515 61 7 0.114754098360656 0.0135922330097087
GO:BP GO:1901700 response to oxygen-containing compound 0.0122850958687962 1739 140 25 0.178571428571429 0.0143760782058654
GO:BP GO:0051254 positive regulation of RNA metabolic process 0.0123053708154716 1714 142 25 0.176056338028169 0.014585764294049
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.0125468917985425 456 131 10 0.0763358778625954 0.0219298245614035
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.012821855663519 1082 97 14 0.144329896907216 0.0129390018484288
GO:BP GO:0050789 regulation of biological process 0.01288523659218 12091 27 25 0.925925925925926 0.00206765362666446
GO:BP GO:0035821 modulation of process of other organism 0.0130617304602352 128 74 4 0.0540540540540541 0.03125
GO:BP GO:0042401 cellular biogenic amine biosynthetic process 0.013431998316903 38 118 3 0.0254237288135593 0.0789473684210526
GO:BP GO:0007275 multicellular organism development 0.0135394799116344 5613 18 12 0.666666666666667 0.00213789417423838
GO:BP GO:2000756 regulation of peptidyl-lysine acetylation 0.0137896976750248 63 72 3 0.0416666666666667 0.0476190476190476
GO:BP GO:0003170 heart valve development 0.0137896976750248 63 72 3 0.0416666666666667 0.0476190476190476
GO:BP GO:0046328 regulation of JNK cascade 0.0140994154455485 133 122 5 0.040983606557377 0.037593984962406
GO:BP GO:0009309 amine biosynthetic process 0.014140861498942 39 118 3 0.0254237288135593 0.0769230769230769
GO:BP GO:0032509 endosome transport via multivesicular body sorting pathway 0.0145021611174894 34 137 3 0.0218978102189781 0.0882352941176471
GO:BP GO:0000041 transition metal ion transport 0.0154444496866174 129 129 5 0.0387596899224806 0.0387596899224806
GO:BP GO:0031323 regulation of cellular metabolic process 0.0161308034626505 6269 135 63 0.466666666666667 0.0100494496729941
GO:BP GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 0.0162870036018548 128 132 5 0.0378787878787879 0.0390625
GO:BP GO:0002714 positive regulation of B cell mediated immunity 0.0163079981178638 38 129 3 0.0232558139534884 0.0789473684210526
GO:BP GO:0002891 positive regulation of immunoglobulin mediated immune response 0.0163079981178638 38 129 3 0.0232558139534884 0.0789473684210526
GO:BP GO:2001235 positive regulation of apoptotic signaling pathway 0.0165919714684312 129 132 5 0.0378787878787879 0.0387596899224806
GO:BP GO:0006826 iron ion transport 0.0165972270932176 80 129 4 0.0310077519379845 0.05
GO:BP GO:0070613 regulation of protein processing 0.0172644035268137 66 76 3 0.0394736842105263 0.0454545454545455
GO:BP GO:0002253 activation of immune response 0.018400636126808 568 61 7 0.114754098360656 0.0123239436619718
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.0187857382074816 184 96 5 0.0520833333333333 0.0271739130434783
GO:BP GO:0080135 regulation of cellular response to stress 0.0187857382074816 725 75 9 0.12 0.0124137931034483
GO:BP GO:1902807 negative regulation of cell cycle G1/S phase transition 0.0189543693674298 134 132 5 0.0378787878787879 0.0373134328358209
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.0189604540714898 2518 97 24 0.247422680412371 0.00953137410643368
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.0190845609309035 1887 142 26 0.183098591549296 0.0137784843667197
GO:BP GO:0019058 viral life cycle 0.0193074915310533 353 51 5 0.0980392156862745 0.0141643059490085
GO:BP GO:0055076 transition metal ion homeostasis 0.0193105555504428 138 129 5 0.0387596899224806 0.036231884057971
GO:BP GO:1901224 positive regulation of NIK/NF-kappaB signaling 0.0195962350866023 68 78 3 0.0384615384615385 0.0441176470588235
GO:BP GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 0.0197196076473895 83 132 4 0.0303030303030303 0.0481927710843374
GO:BP GO:0044092 negative regulation of molecular function 0.0197449892360663 1219 16 5 0.3125 0.00410172272354389
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0197449892360663 1151 97 14 0.144329896907216 0.0121633362293658
GO:BP GO:0048513 animal organ development 0.0201830023725272 3672 9 6 0.666666666666667 0.00163398692810458
GO:BP GO:0055072 iron ion homeostasis 0.0202914662117697 86 129 4 0.0310077519379845 0.0465116279069767
GO:BP GO:0071985 multivesicular body sorting pathway 0.0204902587147546 40 137 3 0.0218978102189781 0.075
GO:BP GO:0009966 regulation of signal transduction 0.020669505565951 3165 137 37 0.27007299270073 0.0116903633491311
GO:BP GO:0009617 response to bacterium 0.0206964624744954 743 134 13 0.0970149253731343 0.0174966352624495
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0206964624744954 5848 135 59 0.437037037037037 0.0100889192886457
GO:BP GO:1903322 positive regulation of protein modification by small protein conjugation or removal 0.0208282345020802 140 131 5 0.0381679389312977 0.0357142857142857
GO:BP GO:0051049 regulation of transport 0.0208415354136835 1809 142 25 0.176056338028169 0.0138197899391929
GO:BP GO:1903900 regulation of viral life cycle 0.0209299911325264 153 74 4 0.0540540540540541 0.0261437908496732
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 0.0212541031140697 1617 142 23 0.161971830985915 0.0142238713667285
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 0.0212541031140697 1617 142 23 0.161971830985915 0.0142238713667285
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 0.0213779486484998 1618 142 23 0.161971830985915 0.0142150803461063
GO:BP GO:1901983 regulation of protein acetylation 0.0214378701920005 78 72 3 0.0416666666666667 0.0384615384615385
GO:BP GO:0000165 MAPK cascade 0.0221215104996503 935 96 12 0.125 0.0128342245989305
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.0225066198448504 2719 97 25 0.257731958762887 0.00919455682236116
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 0.0225066198448504 294 40 4 0.1 0.0136054421768707
GO:BP GO:0050729 positive regulation of inflammatory response 0.0225681554936665 142 82 4 0.0487804878048781 0.028169014084507
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.0226199951213174 197 96 5 0.0520833333333333 0.0253807106598985
GO:BP GO:0051336 regulation of hydrolase activity 0.0226564723325347 1321 87 14 0.160919540229885 0.0105980317940954
GO:BP GO:0043408 regulation of MAPK cascade 0.0229274203290336 730 123 12 0.0975609756097561 0.0164383561643836
GO:BP GO:0019538 protein metabolic process 0.0229653590425418 5808 134 58 0.432835820895522 0.0099862258953168
GO:BP GO:0032880 regulation of protein localization 0.0235448577844288 922 137 15 0.109489051094891 0.0162689804772234
GO:BP GO:0019725 cellular homeostasis 0.0241621568541642 981 142 16 0.112676056338028 0.0163098878695209
GO:BP GO:0070266 necroptotic process 0.024435850218422 46 131 3 0.0229007633587786 0.0652173913043478
GO:BP GO:0045055 regulated exocytosis 0.024435850218422 785 146 14 0.0958904109589041 0.0178343949044586
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0258664904741196 547 146 11 0.0753424657534247 0.020109689213894
GO:BP GO:0080090 regulation of primary metabolic process 0.0258664904741196 6053 135 60 0.444444444444444 0.00991244011234099
GO:BP GO:0023051 regulation of signaling 0.0266783271575534 3578 137 40 0.291970802919708 0.0111794298490777
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0268387585512695 551 146 11 0.0753424657534247 0.0199637023593466
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0269181369777805 470 14 3 0.214285714285714 0.00638297872340425
GO:BP GO:0045597 positive regulation of cell differentiation 0.0279128935765233 879 93 11 0.118279569892473 0.012514220705347
GO:BP GO:0031669 cellular response to nutrient levels 0.0283516678469849 219 93 5 0.0537634408602151 0.0228310502283105
GO:BP GO:0002237 response to molecule of bacterial origin 0.0283995139674279 361 134 8 0.0597014925373134 0.0221606648199446
GO:BP GO:0051817 modulation of process of other organism involved in symbiotic interaction 0.0283995139674279 102 125 4 0.032 0.0392156862745098
GO:BP GO:0007346 regulation of mitotic cell cycle 0.0289502657069311 619 132 11 0.0833333333333333 0.0177705977382876
GO:BP GO:0043312 neutrophil degranulation 0.0294292173116426 482 146 10 0.0684931506849315 0.020746887966805
GO:BP GO:0051050 positive regulation of transport 0.0301375952375355 923 142 15 0.105633802816901 0.0162513542795233
GO:BP GO:0002283 neutrophil activation involved in immune response 0.030455830767177 485 146 10 0.0684931506849315 0.0206185567010309
GO:BP GO:0016579 protein deubiquitination 0.0306928468493289 292 134 7 0.0522388059701493 0.023972602739726
GO:BP GO:0065007 biological regulation 0.0311805361661862 12809 27 25 0.925925925925926 0.00195175267390116
GO:BP GO:0071496 cellular response to external stimulus 0.0314646495006957 322 93 6 0.0645161290322581 0.0186335403726708
GO:BP GO:0000018 regulation of DNA recombination 0.0314780507185922 103 129 4 0.0310077519379845 0.0388349514563107
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.0320225137602284 1184 134 17 0.126865671641791 0.0143581081081081
GO:BP GO:0002224 toll-like receptor signaling pathway 0.0337958965634165 161 134 5 0.0373134328358209 0.031055900621118
GO:BP GO:0007093 mitotic cell cycle checkpoint 0.0338488766522011 164 132 5 0.0378787878787879 0.0304878048780488
GO:BP GO:0051094 positive regulation of developmental process 0.0338488766522011 1341 82 13 0.158536585365854 0.00969425801640567
GO:BP GO:0097300 programmed necrotic cell death 0.0338488766522011 54 131 3 0.0229007633587786 0.0555555555555556
GO:BP GO:0002446 neutrophil mediated immunity 0.0338751428878796 497 146 10 0.0684931506849315 0.0201207243460765
GO:BP GO:0042119 neutrophil activation 0.0342220922236748 498 146 10 0.0684931506849315 0.0200803212851406
GO:BP GO:0010646 regulation of cell communication 0.0342220922236748 3543 79 25 0.316455696202532 0.00705616709003669
GO:BP GO:0046718 viral entry into host cell 0.0347848869107033 141 51 3 0.0588235294117647 0.0212765957446809
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0349895504882367 539 58 6 0.103448275862069 0.0111317254174397
GO:BP GO:0044773 mitotic DNA damage checkpoint 0.0355617590163104 106 132 4 0.0303030303030303 0.0377358490566038
GO:BP GO:0031331 positive regulation of cellular catabolic process 0.0356748553180241 393 19 3 0.157894736842105 0.00763358778625954
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 0.0360377658376525 105 134 4 0.0298507462686567 0.0380952380952381
GO:BP GO:0036230 granulocyte activation 0.0361954954305151 504 146 10 0.0684931506849315 0.0198412698412698
GO:BP GO:0072331 signal transduction by p53 class mediator 0.0361954954305151 268 83 5 0.0602409638554217 0.0186567164179104
GO:BP GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors 0.0365892507816546 59 125 3 0.024 0.0508474576271186
GO:BP GO:0045087 innate immune response 0.0365892507816546 998 75 10 0.133333333333333 0.0100200400801603
GO:BP GO:0050792 regulation of viral process 0.0366246725146545 192 74 4 0.0540540540540541 0.0208333333333333
GO:BP GO:0045088 regulation of innate immune response 0.037497475918518 309 73 5 0.0684931506849315 0.0161812297734628
GO:BP GO:0006801 superoxide metabolic process 0.0375717437456315 67 112 3 0.0267857142857143 0.0447761194029851
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.0375717437456315 3241 100 28 0.28 0.00863930885529158
GO:BP GO:0070646 protein modification by small protein removal 0.0376568876196744 310 134 7 0.0522388059701493 0.0225806451612903
GO:BP GO:0048869 cellular developmental process 0.0376568876196744 4428 22 11 0.5 0.00248419150858175
GO:BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 0.0378435699818956 198 73 4 0.0547945205479452 0.0202020202020202
GO:BP GO:0050900 leukocyte migration 0.0380266796647135 511 146 10 0.0684931506849315 0.0195694716242661
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 0.0380266796647135 243 131 6 0.0458015267175573 0.0246913580246914
GO:BP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 0.0385920853926432 58 132 3 0.0227272727272727 0.0517241379310345
GO:BP GO:0070534 protein K63-linked ubiquitination 0.0393964310486377 59 131 3 0.0229007633587786 0.0508474576271186
GO:BP GO:0031668 cellular response to extracellular stimulus 0.0396543839221126 248 93 5 0.0537634408602151 0.0201612903225806
GO:BP GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint 0.0398351224693564 59 132 3 0.0227272727272727 0.0508474576271186
GO:BP GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint 0.0398351224693564 59 132 3 0.0227272727272727 0.0508474576271186
GO:BP GO:0044774 mitotic DNA integrity checkpoint 0.0398351224693564 112 132 4 0.0303030303030303 0.0357142857142857
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 0.0403841712605061 1851 142 24 0.169014084507042 0.0129659643435981
GO:BP GO:0046916 cellular transition metal ion homeostasis 0.0410561897587574 116 129 4 0.0310077519379845 0.0344827586206897
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 0.041211347301402 203 74 4 0.0540540540540541 0.0197044334975369
GO:BP GO:1902402 signal transduction involved in mitotic DNA damage checkpoint 0.0421346232757715 61 132 3 0.0227272727272727 0.0491803278688525
GO:BP GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint 0.0421346232757715 61 132 3 0.0227272727272727 0.0491803278688525
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 0.0423655830101233 1967 142 25 0.176056338028169 0.012709710218607
GO:BP GO:0010467 gene expression 0.0423655830101233 6179 83 39 0.469879518072289 0.00631170092247937
GO:BP GO:0031399 regulation of protein modification process 0.0427268495091062 1671 133 21 0.157894736842105 0.0125673249551167
GO:BP GO:0007254 JNK cascade 0.0430259579788099 195 122 5 0.040983606557377 0.0256410256410256
GO:BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 0.0442809100379171 182 132 5 0.0378787878787879 0.0274725274725275
GO:BP GO:0050830 defense response to Gram-positive bacterium 0.0445713120528332 101 82 3 0.0365853658536585 0.0297029702970297
GO:BP GO:0072413 signal transduction involved in mitotic cell cycle checkpoint 0.0448743147688558 63 132 3 0.0227272727272727 0.0476190476190476
GO:BP GO:0051051 negative regulation of transport 0.0449251459735459 474 139 9 0.0647482014388489 0.0189873417721519
GO:BP GO:0019882 antigen processing and presentation 0.0453381622960536 234 144 6 0.0416666666666667 0.0256410256410256
GO:BP GO:0045930 negative regulation of mitotic cell cycle 0.0453608271822983 333 132 7 0.053030303030303 0.021021021021021
GO:BP GO:0031398 positive regulation of protein ubiquitination 0.0457534002412095 120 131 4 0.0305343511450382 0.0333333333333333
GO:BP GO:0043299 leukocyte degranulation 0.0464733500358967 535 146 10 0.0684931506849315 0.0186915887850467
GO:BP GO:0009892 negative regulation of metabolic process 0.046708426735791 3479 100 29 0.29 0.00833572865766025
GO:BP GO:0009896 positive regulation of catabolic process 0.0479197332670325 464 19 3 0.157894736842105 0.00646551724137931
GO:BP GO:0070997 neuron death 0.0479521995968864 365 68 5 0.0735294117647059 0.0136986301369863
GO:BP GO:0031667 response to nutrient levels 0.0481536648008772 482 93 7 0.0752688172043011 0.0145228215767635
GO:BP GO:0031640 killing of cells of other organism 0.0482216464528828 69 125 3 0.024 0.0434782608695652
GO:BP GO:0071347 cellular response to interleukin-1 0.0485741926274287 185 134 5 0.0373134328358209 0.027027027027027
GO:BP GO:0009891 positive regulation of biosynthetic process 0.0499555412010212 2004 142 25 0.176056338028169 0.0124750499001996
GO:CC GO:0098552 side of membrane 9.34214281801423e-08 619 144 23 0.159722222222222 0.037156704361874
GO:CC GO:0009986 cell surface 2.16211889938405e-07 899 75 19 0.253333333333333 0.0211345939933259
GO:CC GO:0009897 external side of plasma membrane 7.16156473150135e-07 408 75 13 0.173333333333333 0.0318627450980392
GO:CC GO:0042612 MHC class I protein complex 1.76718451921254e-05 8 144 4 0.0277777777777778 0.5
GO:CC GO:0031982 vesicle 0.000318412123276433 4055 146 55 0.376712328767123 0.0135635018495684
GO:CC GO:0005768 endosome 0.0009737717501105 987 144 21 0.145833333333333 0.0212765957446809
GO:CC GO:0030670 phagocytic vesicle membrane 0.00112997251133468 76 144 6 0.0416666666666667 0.0789473684210526
GO:CC GO:0042611 MHC protein complex 0.00122023605452442 24 144 4 0.0277777777777778 0.166666666666667
GO:CC GO:0031410 cytoplasmic vesicle 0.00198855429810982 2424 146 36 0.246575342465753 0.0148514851485149
GO:CC GO:0030134 COPII-coated ER to Golgi transport vesicle 0.00198855429810982 90 88 5 0.0568181818181818 0.0555555555555556
GO:CC GO:0097708 intracellular vesicle 0.00198855429810982 2428 146 36 0.246575342465753 0.014827018121911
GO:CC GO:0045335 phagocytic vesicle 0.00229792431990947 137 144 7 0.0486111111111111 0.0510948905109489
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00255612485709312 779 146 17 0.116438356164384 0.0218228498074454
GO:CC GO:0045121 membrane raft 0.00255612485709312 335 107 9 0.0841121495327103 0.026865671641791
GO:CC GO:0098857 membrane microdomain 0.00255612485709312 335 107 9 0.0841121495327103 0.026865671641791
GO:CC GO:0010008 endosome membrane 0.00259262659177124 505 144 13 0.0902777777777778 0.0257425742574257
GO:CC GO:0012506 vesicle membrane 0.0027814672748516 800 146 17 0.116438356164384 0.02125
GO:CC GO:0030658 transport vesicle membrane 0.00339674084740162 209 144 8 0.0555555555555556 0.0382775119617225
GO:CC GO:0098588 bounding membrane of organelle 0.00339674084740162 2158 146 32 0.219178082191781 0.0148285449490269
GO:CC GO:0031226 intrinsic component of plasma membrane 0.00448150346319654 1726 146 27 0.184931506849315 0.0156431054461182
GO:CC GO:0030135 coated vesicle 0.00448150346319654 295 38 5 0.131578947368421 0.0169491525423729
GO:CC GO:0005887 integral component of plasma membrane 0.00476252800566854 1645 146 26 0.178082191780822 0.0158054711246201
GO:CC GO:1903561 extracellular vesicle 0.00582591226898411 2261 146 32 0.219178082191781 0.0141530296329058
GO:CC GO:0043230 extracellular organelle 0.00582591226898411 2263 146 32 0.219178082191781 0.0141405214317278
GO:CC GO:0055038 recycling endosome membrane 0.00582591226898411 84 144 5 0.0347222222222222 0.0595238095238095
GO:CC GO:0070062 extracellular exosome 0.00615255863448198 2176 146 31 0.212328767123288 0.0142463235294118
GO:CC GO:0055037 recycling endosome 0.00660142781192892 188 144 7 0.0486111111111111 0.0372340425531915
GO:CC GO:0030667 secretory granule membrane 0.00660142781192892 303 146 9 0.0616438356164384 0.0297029702970297
GO:CC GO:0000139 Golgi membrane 0.0080813911818955 771 144 15 0.104166666666667 0.0194552529182879
GO:CC GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane 0.0080813911818955 25 144 3 0.0208333333333333 0.12
GO:CC GO:0098553 lumenal side of endoplasmic reticulum membrane 0.0080813911818955 25 144 3 0.0208333333333333 0.12
GO:CC GO:0098797 plasma membrane protein complex 0.0080813911818955 694 144 14 0.0972222222222222 0.0201729106628242
GO:CC GO:0012507 ER to Golgi transport vesicle membrane 0.0083020785454289 57 144 4 0.0277777777777778 0.0701754385964912
GO:CC GO:0030666 endocytic vesicle membrane 0.0113535864134154 159 144 6 0.0416666666666667 0.0377358490566038
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.0113535864134154 158 145 6 0.0413793103448276 0.0379746835443038
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.0138863797375333 166 145 6 0.0413793103448276 0.036144578313253
GO:CC GO:0005769 early endosome 0.0149604414899496 378 89 7 0.0786516853932584 0.0185185185185185
GO:CC GO:0098576 lumenal side of membrane 0.0149604414899496 33 144 3 0.0208333333333333 0.0909090909090909
GO:CC GO:0005576 extracellular region 0.0149604414899496 4567 22 12 0.545454545454545 0.00262754543463981
GO:CC GO:0030139 endocytic vesicle 0.0167515101937432 306 144 8 0.0555555555555556 0.0261437908496732
GO:CC GO:0030662 coated vesicle membrane 0.0167515101937432 177 144 6 0.0416666666666667 0.0338983050847458
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0208467143398281 885 144 15 0.104166666666667 0.0169491525423729
GO:CC GO:0005829 cytosol 0.0268638799950585 5303 140 54 0.385714285714286 0.0101829153309447
GO:CC GO:0030133 transport vesicle 0.0275316133071845 414 144 9 0.0625 0.0217391304347826
GO:CC GO:0071944 cell periphery 0.0295823636861489 6169 112 50 0.446428571428571 0.00810504133571081
GO:CC GO:0016021 integral component of membrane 0.0302619448694774 5711 146 59 0.404109589041096 0.0103309402906671
GO:CC GO:0099503 secretory vesicle 0.0315683841731373 1020 146 16 0.10958904109589 0.0156862745098039
GO:CC GO:0031224 intrinsic component of membrane 0.0332710805223803 5868 146 60 0.410958904109589 0.0102249488752556
GO:CC GO:0030672 synaptic vesicle membrane 0.0344188144585526 111 125 4 0.032 0.036036036036036
GO:CC GO:0099501 exocytic vesicle membrane 0.0344188144585526 111 125 4 0.032 0.036036036036036
GO:CC GO:0031901 early endosome membrane 0.0361530383416138 159 89 4 0.0449438202247191 0.0251572327044025
GO:CC GO:0016020 membrane 0.0365137086623281 9838 125 79 0.632 0.00803008741614149
GO:CC GO:0005886 plasma membrane 0.0411884082863615 5681 112 46 0.410714285714286 0.00809716599190283
GO:CC GO:0043235 receptor complex 0.0485151162169535 522 129 9 0.0697674418604651 0.0172413793103448
GO:MF GO:0005031 tumor necrosis factor-activated receptor activity 2.55470965471676e-06 10 8 3 0.375 0.3
GO:MF GO:0005035 death receptor activity 2.55470965471676e-06 12 8 3 0.375 0.25
GO:MF GO:0019955 cytokine binding 6.08037477783693e-05 138 63 7 0.111111111111111 0.0507246376811594
GO:MF GO:0032813 tumor necrosis factor receptor superfamily binding 6.88398279265386e-05 49 122 6 0.0491803278688525 0.122448979591837
GO:MF GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 6.88398279265386e-05 38 83 5 0.0602409638554217 0.131578947368421
GO:MF GO:0005164 tumor necrosis factor receptor binding 0.000143976914259 32 122 5 0.040983606557377 0.15625
GO:MF GO:0004896 cytokine receptor activity 0.000409566704358733 99 86 6 0.0697674418604651 0.0606060606060606
GO:MF GO:0019899 enzyme binding 0.000430868346069543 2074 134 33 0.246268656716418 0.0159112825458052
GO:MF GO:0061134 peptidase regulator activity 0.00101637991587673 224 15 4 0.266666666666667 0.0178571428571429
GO:MF GO:0046977 TAP binding 0.00126453535200421 9 144 3 0.0208333333333333 0.333333333333333
GO:MF GO:0140375 immune receptor activity 0.00126453535200421 133 86 6 0.0697674418604651 0.0451127819548872
GO:MF GO:0002020 protease binding 0.00134169365975506 133 132 7 0.053030303030303 0.0526315789473684
GO:MF GO:0016505 peptidase activator activity involved in apoptotic process 0.00219604390494784 19 83 3 0.036144578313253 0.157894736842105
GO:MF GO:0019900 kinase binding 0.00261665302232755 752 134 16 0.119402985074627 0.0212765957446809
GO:MF GO:0004888 transmembrane signaling receptor activity 0.00360042648810197 1269 9 5 0.555555555555556 0.00394011032308905
GO:MF GO:0038023 signaling receptor activity 0.00425445517484463 1458 68 15 0.220588235294118 0.0102880658436214
GO:MF GO:0005515 protein binding 0.00425445517484463 14767 146 132 0.904109589041096 0.00893885013882305
GO:MF GO:0060089 molecular transducer activity 0.00425445517484463 1458 68 15 0.220588235294118 0.0102880658436214
GO:MF GO:0042802 identical protein binding 0.00498473583771202 2067 133 29 0.218045112781955 0.0140299951620706
GO:MF GO:0004866 endopeptidase inhibitor activity 0.00500514428432479 176 14 3 0.214285714285714 0.0170454545454545
GO:MF GO:0030414 peptidase inhibitor activity 0.00531069842065308 182 14 3 0.214285714285714 0.0164835164835165
GO:MF GO:0061135 endopeptidase regulator activity 0.00562466866687916 188 14 3 0.214285714285714 0.0159574468085106
GO:MF GO:0016504 peptidase activator activity 0.0133347704036713 42 83 3 0.036144578313253 0.0714285714285714
GO:MF GO:0019838 growth factor binding 0.0156840256253837 138 63 4 0.0634920634920635 0.0289855072463768
GO:MF GO:0140272 exogenous protein binding 0.0156840256253837 77 51 3 0.0588235294117647 0.038961038961039
GO:MF GO:0001618 virus receptor activity 0.0156840256253837 76 51 3 0.0588235294117647 0.0394736842105263
GO:MF GO:0042605 peptide antigen binding 0.0185705496631942 30 144 3 0.0208333333333333 0.1
GO:MF GO:0005126 cytokine receptor binding 0.0210534113389553 275 122 7 0.0573770491803279 0.0254545454545455
GO:MF GO:0098772 molecular function regulator 0.0210534113389553 2363 16 7 0.4375 0.00296233601354211
GO:MF GO:0004857 enzyme inhibitor activity 0.0227363421522579 385 14 3 0.214285714285714 0.00779220779220779
GO:MF GO:0005507 copper ion binding 0.0244927514140549 61 88 3 0.0340909090909091 0.0491803278688525
GO:MF GO:0019901 protein kinase binding 0.0269113752724692 673 134 12 0.0895522388059701 0.0178306092124814
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.0334965005976278 314 122 7 0.0573770491803279 0.0222929936305732
GO:MF GO:0005102 signaling receptor binding 0.0378999488351065 1672 98 17 0.173469387755102 0.0101674641148325
HP HP:0012192 Cutaneous T-cell lymphoma 0.00229351249688238 3 50 3 0.06 1
HP HP:0002733 Abnormality of the lymph nodes 0.00337594181951003 196 18 7 0.388888888888889 0.0357142857142857
HP HP:0002716 Lymphadenopathy 0.00337594181951003 187 18 7 0.388888888888889 0.0374331550802139
HP HP:0003765 Psoriasiform dermatitis 0.00394286902256355 25 144 7 0.0486111111111111 0.28
HP HP:0012190 T-cell lymphoma 0.00431285853544782 11 68 4 0.0588235294117647 0.363636363636364
HP HP:0001019 Erythroderma 0.00431285853544782 49 50 6 0.12 0.122448979591837
HP HP:0002665 Lymphoma 0.00771135890295667 98 18 5 0.277777777777778 0.0510204081632653
HP HP:0011895 Anemia due to reduced life span of red cells 0.0141234701077047 122 18 5 0.277777777777778 0.040983606557377
HP HP:0000554 Uveitis 0.0141234701077047 45 9 3 0.333333333333333 0.0666666666666667
HP HP:0100533 Inflammatory abnormality of the eye 0.0141234701077047 193 18 6 0.333333333333333 0.0310880829015544
HP HP:0001878 Hemolytic anemia 0.0141234701077047 122 18 5 0.277777777777778 0.040983606557377
HP HP:0032169 Severe infection 0.0156387178962472 28 16 3 0.1875 0.107142857142857
HP HP:0004844 Coombs-positive hemolytic anemia 0.0156387178962472 7 68 3 0.0441176470588235 0.428571428571429
HP HP:0010701 Abnormal immunoglobulin level 0.0161136030357518 219 18 6 0.333333333333333 0.0273972602739726
HP HP:0005372 Abnormality of B cell physiology 0.0161136030357518 220 18 6 0.333333333333333 0.0272727272727273
HP HP:0012539 Non-Hodgkin lymphoma 0.0162758382310792 35 68 5 0.0735294117647059 0.142857142857143
HP HP:0031409 Abnormal lymphocyte physiology 0.0231819285283843 246 18 6 0.333333333333333 0.024390243902439
HP HP:0011450 Unusual CNS infection 0.0231819285283843 87 48 6 0.125 0.0689655172413793
HP HP:0005368 Abnormality of humoral immunity 0.0231819285283843 249 18 6 0.333333333333333 0.0240963855421687
HP HP:0004332 Abnormal lymphocyte morphology 0.0231819285283843 156 50 8 0.16 0.0512820512820513
HP HP:0100725 Lichenification 0.0246642412516739 13 50 3 0.06 0.230769230769231
HP HP:0100806 Sepsis 0.0246642412516739 91 48 6 0.125 0.0659340659340659
HP HP:0032158 Unusual infection by anatomical site 0.0246642412516739 91 48 6 0.125 0.0659340659340659
HP HP:0100646 Thyroiditis 0.0246642412516739 41 68 5 0.0735294117647059 0.121951219512195
HP HP:0001973 Autoimmune thrombocytopenia 0.0284716218047221 39 18 3 0.166666666666667 0.0769230769230769
HP HP:0002720 Decreased circulating IgA level 0.0284716218047221 39 18 3 0.166666666666667 0.0769230769230769
HP HP:0001287 Meningitis 0.0404596410144052 72 68 6 0.0882352941176471 0.0833333333333333
HP HP:0002721 Immunodeficiency 0.04984946468527 204 18 5 0.277777777777778 0.0245098039215686
HP HP:0008404 Nail dystrophy 0.04984946468527 114 18 4 0.222222222222222 0.0350877192982456
HP HP:0045073 Serositis 0.04984946468527 40 88 5 0.0568181818181818 0.125
HP HP:0002113 Pulmonary infiltrates 0.04984946468527 53 38 4 0.105263157894737 0.0754716981132075
KEGG KEGG:04060 Cytokine-cytokine receptor interaction 4.78690639641314e-07 293 9 7 0.777777777777778 0.0238907849829352
KEGG KEGG:04940 Type I diabetes mellitus 0.000240725423822697 40 82 6 0.0731707317073171 0.15
KEGG KEGG:04064 NF-kappa B signaling pathway 0.00129933434977986 102 125 9 0.072 0.0882352941176471
KEGG KEGG:04514 Cell adhesion molecules 0.00129933434977986 146 50 7 0.14 0.0479452054794521
KEGG KEGG:05320 Autoimmune thyroid disease 0.00187620878558315 49 68 5 0.0735294117647059 0.102040816326531
KEGG KEGG:04659 Th17 cell differentiation 0.00339762940670321 104 86 7 0.0813953488372093 0.0673076923076923
KEGG KEGG:05330 Allograft rejection 0.00448781724111349 34 68 4 0.0588235294117647 0.117647058823529
KEGG KEGG:05332 Graft-versus-host disease 0.005486131538323 37 68 4 0.0588235294117647 0.108108108108108
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 0.00587812069718143 216 82 9 0.109756097560976 0.0416666666666667
KEGG KEGG:04668 TNF signaling pathway 0.00587812069718143 112 123 8 0.0650406504065041 0.0714285714285714
KEGG KEGG:05321 Inflammatory bowel disease 0.00794336484178949 62 86 5 0.0581395348837209 0.0806451612903226
KEGG KEGG:04658 Th1 and Th2 cell differentiation 0.00794336484178949 89 61 5 0.0819672131147541 0.0561797752808989
KEGG KEGG:05340 Primary immunodeficiency 0.0180544547708229 37 48 3 0.0625 0.0810810810810811
KEGG KEGG:04660 T cell receptor signaling pathway 0.0375040839285354 103 50 4 0.08 0.0388349514563107
KEGG KEGG:05169 Epstein-Barr virus infection 0.0375040839285354 198 146 10 0.0684931506849315 0.0505050505050505
KEGG KEGG:04210 Apoptosis 0.0375040839285354 136 39 4 0.102564102564103 0.0294117647058824
KEGG KEGG:04612 Antigen processing and presentation 0.0375040839285354 69 75 4 0.0533333333333333 0.0579710144927536
KEGG KEGG:05416 Viral myocarditis 0.0433804752651784 56 50 3 0.06 0.0535714285714286
KEGG KEGG:05162 Measles 0.0489085893187738 139 125 7 0.056 0.0503597122302158
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 4.13934852315735e-09 842 10 10 1 0.0118764845605701
REAC REAC:R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 1.05829580109336e-08 100 9 6 0.666666666666667 0.06
REAC REAC:R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1.70430520170471e-07 10 18 4 0.222222222222222 0.4
REAC REAC:R-HSA-5669034 TNFs bind their physiological receptors 2.39887111965685e-07 29 85 7 0.0823529411764706 0.241379310344828
REAC REAC:R-HSA-168256 Immune System 9.57407959578588e-06 2139 10 10 1 0.00467508181393174
REAC REAC:R-HSA-1236977 Endosomal/Vacuolar pathway 0.000702121619686333 11 144 4 0.0277777777777778 0.363636363636364
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.00247472405026354 446 134 17 0.126865671641791 0.0381165919282511
REAC REAC:R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 0.0128269169188094 25 144 4 0.0277777777777778 0.16
REAC REAC:R-HSA-8878171 Transcriptional regulation by RUNX1 0.0128269169188094 200 18 4 0.222222222222222 0.02
REAC REAC:R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters 0.0128269169188094 20 75 3 0.04 0.15
REAC REAC:R-HSA-877300 Interferon gamma signaling 0.0128269169188094 87 75 5 0.0666666666666667 0.0574712643678161
REAC REAC:R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis 0.025329114552821 26 75 3 0.04 0.115384615384615
REAC REAC:R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.0283881070542887 110 73 5 0.0684931506849315 0.0454545454545455
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 0.0302836525667268 66 73 4 0.0547945205479452 0.0606060606060606
REAC REAC:R-HSA-5689896 Ovarian tumor domain proteases 0.0319295430098471 38 134 4 0.0298507462686567 0.105263157894737
TF TF:M10004 Factor: NF-kappaB2; motif: GGGRAANYCCC 0.0144774557461634 1073 102 19 0.186274509803922 0.0177073625349487
WP WP:WP254 Apoptosis 0.00191464709454546 86 132 9 0.0681818181818182 0.104651162790698
WP WP:WP2328 Allograft Rejection 0.00191464709454546 88 68 7 0.102941176470588 0.0795454545454545
WP WP:WP1772 Apoptosis Modulation and Signaling 0.00240920489911031 93 132 9 0.0681818181818182 0.0967741935483871
WP WP:WP453 Inflammatory Response Pathway 0.00343712376458123 33 50 4 0.08 0.121212121212121
WP WP:WP69 T-Cell antigen Receptor (TCR) Signaling Pathway 0.00704827346046841 91 68 6 0.0882352941176471 0.0659340659340659
WP WP:WP4484 Control of immune tolerance by vasoactive intestinal peptide 0.0071278661861044 13 68 3 0.0441176470588235 0.230769230769231
WP WP:WP3863 T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection 0.0203558745243 62 50 4 0.08 0.0645161290322581
WP WP:WP4754 IL-18 signaling pathway 0.0396803838925085 279 7 3 0.428571428571429 0.010752688172043
WP WP:WP4559 Interactions between immune cells and microRNAs in tumor microenvironment 0.0461305555872009 40 48 3 0.0625 0.075

pTNI02 transcription factor target enrichment of top program genes

TF enrichment of pTNI02
TFs corrosponding to activation of pTNI02. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.