pEpiTp14 program activity among Epithelial cells

Activation of pEpiTp14
pEpiTp14 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpiTp14 by different cell subtypes
pEpiTp14 gene program activation among cells of different subtypes (Epithelial cells).

pEpiTp14 top program genes

Top genes of pEpiTp14 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpiTp14 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpiTp14
pEpiTp14 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:306 Ribosome, cytoplasmic 3.02452495209813e-09 80 20 9 0.45 0.1125
CORUM CORUM:305 40S ribosomal subunit, cytoplasmic 4.51064333779501e-06 33 19 5 0.263157894736842 0.151515151515152
CORUM CORUM:338 40S ribosomal subunit, cytoplasmic 4.51064333779501e-06 31 19 5 0.263157894736842 0.161290322580645
CORUM CORUM:308 60S ribosomal subunit, cytoplasmic 0.00072149994458006 47 20 4 0.2 0.0851063829787234
CORUM CORUM:3055 Nop56p-associated pre-rRNA complex 0.00108457918065967 104 20 5 0.25 0.0480769230769231
GO:BP GO:0045047 protein targeting to ER 1.04382418412814e-14 113 20 10 0.5 0.0884955752212389
GO:BP GO:0072599 establishment of protein localization to endoplasmic reticulum 1.04382418412814e-14 117 20 10 0.5 0.0854700854700855
GO:BP GO:0070972 protein localization to endoplasmic reticulum 6.80355507579764e-14 146 20 10 0.5 0.0684931506849315
GO:BP GO:0006614 SRP-dependent cotranslational protein targeting to membrane 1.25663175837684e-13 96 20 9 0.45 0.09375
GO:BP GO:0006613 cotranslational protein targeting to membrane 1.77008646385553e-13 102 20 9 0.45 0.0882352941176471
GO:BP GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 8.37775438291375e-13 123 20 9 0.45 0.0731707317073171
GO:BP GO:0006612 protein targeting to membrane 8.79673552338068e-13 204 20 10 0.5 0.0490196078431373
GO:BP GO:0000956 nuclear-transcribed mRNA catabolic process 1.24905499070655e-12 214 20 10 0.5 0.0467289719626168
GO:BP GO:0006402 mRNA catabolic process 7.41026928464327e-12 384 20 11 0.55 0.0286458333333333
GO:BP GO:0019083 viral transcription 1.73682798313252e-11 181 20 9 0.45 0.0497237569060773
GO:BP GO:0006401 RNA catabolic process 1.79460398910444e-11 424 20 11 0.55 0.0259433962264151
GO:BP GO:0006605 protein targeting 2.527864536106e-11 441 20 11 0.55 0.0249433106575964
GO:BP GO:0019080 viral gene expression 3.163217658746e-11 199 20 9 0.45 0.0452261306532663
GO:BP GO:0006413 translational initiation 3.21630166082076e-11 201 20 9 0.45 0.0447761194029851
GO:BP GO:0090150 establishment of protein localization to membrane 9.52291955401855e-11 351 20 10 0.5 0.0284900284900285
GO:BP GO:0034655 nucleobase-containing compound catabolic process 2.91792327933555e-10 567 20 11 0.55 0.0194003527336861
GO:BP GO:0072594 establishment of protein localization to organelle 3.78143138018188e-10 584 20 11 0.55 0.0188356164383562
GO:BP GO:0046700 heterocycle catabolic process 4.95936380563797e-10 602 20 11 0.55 0.0182724252491694
GO:BP GO:0044270 cellular nitrogen compound catabolic process 5.22994142922623e-10 608 20 11 0.55 0.0180921052631579
GO:BP GO:0019439 aromatic compound catabolic process 6.46471509325959e-10 623 20 11 0.55 0.0176565008025682
GO:BP GO:0016071 mRNA metabolic process 8.66752656817177e-10 874 20 12 0.6 0.0137299771167048
GO:BP GO:1901361 organic cyclic compound catabolic process 9.44352430291754e-10 651 20 11 0.55 0.0168970814132104
GO:BP GO:0006886 intracellular protein transport 2.75294663127219e-08 1186 20 12 0.6 0.0101180438448567
GO:BP GO:0072657 protein localization to membrane 3.20889567728681e-08 665 20 10 0.5 0.0150375939849624
GO:BP GO:0044265 cellular macromolecule catabolic process 3.89125303077787e-08 1231 20 12 0.6 0.00974817221770918
GO:BP GO:0033365 protein localization to organelle 9.36802216733548e-08 1017 20 11 0.55 0.0108161258603736
GO:BP GO:0046907 intracellular transport 1.44415635653192e-07 1767 20 13 0.65 0.00735710243350311
GO:BP GO:0009057 macromolecule catabolic process 2.52415796175722e-07 1468 20 12 0.6 0.00817438692098093
GO:BP GO:0051649 establishment of localization in cell 2.52415796175722e-07 2813 20 15 0.75 0.0053323853537149
GO:BP GO:0015031 protein transport 3.82762729486198e-07 1929 20 13 0.65 0.00673924313115604
GO:BP GO:0015833 peptide transport 4.82422832386852e-07 1971 20 13 0.65 0.00659563673262303
GO:BP GO:0042886 amide transport 5.83332608525618e-07 2007 20 13 0.65 0.0064773293472845
GO:BP GO:0016032 viral process 6.50701741567223e-07 942 20 10 0.5 0.0106157112526539
GO:BP GO:0045184 establishment of protein localization 6.50701741567223e-07 2035 20 13 0.65 0.00638820638820639
GO:BP GO:0044403 biological process involved in symbiotic interaction 1.12821194612564e-06 1001 20 10 0.5 0.00999000999000999
GO:BP GO:0006412 translation 1.72993344715493e-06 764 20 9 0.45 0.0117801047120419
GO:BP GO:0006518 peptide metabolic process 2.16533342209835e-06 955 22 10 0.454545454545455 0.0104712041884817
GO:BP GO:0043043 peptide biosynthetic process 2.18593785148207e-06 790 20 9 0.45 0.0113924050632911
GO:BP GO:0010629 negative regulation of gene expression 2.73502264123476e-06 1460 20 11 0.55 0.00753424657534247
GO:BP GO:0071705 nitrogen compound transport 2.75057072758105e-06 2322 20 13 0.65 0.00559862187769164
GO:BP GO:0044248 cellular catabolic process 3.05430307880224e-06 2347 20 13 0.65 0.00553898593949723
GO:BP GO:0051641 cellular localization 4.28058502099605e-06 3541 20 15 0.75 0.00423609149957639
GO:BP GO:0034613 cellular protein localization 6.00834497414563e-06 2014 20 12 0.6 0.00595829195630586
GO:BP GO:0070727 cellular macromolecule localization 6.20427325435675e-06 2024 20 12 0.6 0.00592885375494071
GO:BP GO:0006811 ion transport 6.34702574955496e-06 3661 20 15 0.75 0.00409724119093144
GO:BP GO:0043604 amide biosynthetic process 7.42593996807034e-06 932 20 9 0.45 0.00965665236051502
GO:BP GO:0006810 transport 8.4906982261245e-06 5224 20 17 0.85 0.0032542113323124
GO:BP GO:0051234 establishment of localization 1.29576572607744e-05 5372 20 17 0.85 0.00316455696202532
GO:BP GO:0042255 ribosome assembly 1.50687783048999e-05 64 19 4 0.210526315789474 0.0625
GO:BP GO:0009056 catabolic process 1.63070963246113e-05 2744 20 13 0.65 0.00473760932944606
GO:BP GO:0071702 organic substance transport 1.71807482441283e-05 2766 20 13 0.65 0.0046999276934201
GO:BP GO:0008104 protein localization 1.71807482441283e-05 2770 20 13 0.65 0.00469314079422383
GO:BP GO:0043603 cellular amide metabolic process 1.71807482441283e-05 1241 22 10 0.454545454545455 0.008058017727639
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 1.71807482441283e-05 2255 20 12 0.6 0.00532150776053215
GO:BP GO:1901575 organic substance catabolic process 1.73850570543589e-05 2267 20 12 0.6 0.00529333921482135
GO:BP GO:0000028 ribosomal small subunit assembly 2.33034960963429e-05 19 19 3 0.157894736842105 0.157894736842105
GO:BP GO:0042274 ribosomal small subunit biogenesis 2.33034960963429e-05 74 19 4 0.210526315789474 0.0540540540540541
GO:BP GO:0006820 anion transport 2.58833512257344e-05 2889 20 13 0.65 0.00449982692973347
GO:BP GO:0022618 ribonucleoprotein complex assembly 3.52232244157346e-05 197 19 5 0.263157894736842 0.0253807106598985
GO:BP GO:0071826 ribonucleoprotein complex subunit organization 4.11289613594218e-05 204 19 5 0.263157894736842 0.0245098039215686
GO:BP GO:0033036 macromolecule localization 8.72692967847332e-05 3218 20 13 0.65 0.00403977625854568
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 9.32869298332257e-05 3241 20 13 0.65 0.00401110768281395
GO:BP GO:0002181 cytoplasmic translation 9.73600286408755e-05 103 20 4 0.2 0.0388349514563107
GO:BP GO:0022613 ribonucleoprotein complex biogenesis 9.73600286408755e-05 446 19 6 0.315789473684211 0.0134529147982063
GO:BP GO:0009892 negative regulation of metabolic process 0.000202139437100798 3479 20 13 0.65 0.00373670594998563
GO:BP GO:0042254 ribosome biogenesis 0.000274472008728766 307 19 5 0.263157894736842 0.0162866449511401
GO:BP GO:0006396 RNA processing 0.000461346268394642 964 18 7 0.388888888888889 0.00726141078838174
GO:BP GO:0051179 localization 0.000461346268394642 6901 20 17 0.85 0.0024634110998406
GO:BP GO:0022900 electron transport chain 0.000665175567277399 180 7 3 0.428571428571429 0.0166666666666667
GO:BP GO:0016070 RNA metabolic process 0.000939541088979654 4710 20 14 0.7 0.0029723991507431
GO:BP GO:0006364 rRNA processing 0.00118137536434435 224 18 4 0.222222222222222 0.0178571428571429
GO:BP GO:1901566 organonitrogen compound biosynthetic process 0.00135444441320752 1853 20 9 0.45 0.00485698866702644
GO:BP GO:0016072 rRNA metabolic process 0.00136195956239614 234 18 4 0.222222222222222 0.0170940170940171
GO:BP GO:0034622 cellular protein-containing complex assembly 0.00151046482943256 1107 19 7 0.368421052631579 0.00632339656729901
GO:BP GO:0090304 nucleic acid metabolic process 0.00278619906046444 5226 20 14 0.7 0.00267891312667432
GO:BP GO:0034599 cellular response to oxidative stress 0.00294595817340813 316 7 3 0.428571428571429 0.00949367088607595
GO:BP GO:2001242 regulation of intrinsic apoptotic signaling pathway 0.00339126692373007 167 13 3 0.230769230769231 0.0179640718562874
GO:BP GO:0062197 cellular response to chemical stress 0.00430125023575912 365 7 3 0.428571428571429 0.00821917808219178
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.00728592886291234 5746 20 14 0.7 0.00243647754959972
GO:BP GO:0048519 negative regulation of biological process 0.00737072967553766 5757 20 14 0.7 0.00243182212958138
GO:BP GO:0034470 ncRNA processing 0.0078056047587422 397 18 4 0.222222222222222 0.0100755667506297
GO:BP GO:0006979 response to oxidative stress 0.0078056047587422 466 7 3 0.428571428571429 0.00643776824034335
GO:BP GO:0046483 heterocycle metabolic process 0.0088323924290383 5904 20 14 0.7 0.00237127371273713
GO:BP GO:0000209 protein polyubiquitination 0.00904060422038348 342 22 4 0.181818181818182 0.0116959064327485
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.00949416042881208 5956 20 14 0.7 0.00235057085292142
GO:BP GO:0010468 regulation of gene expression 0.00993509229081078 5196 20 13 0.65 0.00250192455735181
GO:BP GO:0033554 cellular response to stress 0.0100814814449181 2111 28 10 0.357142857142857 0.00473709142586452
GO:BP GO:0006091 generation of precursor metabolites and energy 0.0102376205073543 538 7 3 0.428571428571429 0.00557620817843866
GO:BP GO:0071456 cellular response to hypoxia 0.0112914422853007 212 17 3 0.176470588235294 0.0141509433962264
GO:BP GO:0036294 cellular response to decreased oxygen levels 0.0122659503351725 222 17 3 0.176470588235294 0.0135135135135135
GO:BP GO:0065003 protein-containing complex assembly 0.0122659503351725 1680 19 7 0.368421052631579 0.00416666666666667
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 0.0122659503351725 294 13 3 0.230769230769231 0.0102040816326531
GO:BP GO:0010467 gene expression 0.0124740368950107 6179 20 14 0.7 0.0022657387926849
GO:BP GO:0034645 cellular macromolecule biosynthetic process 0.0125755644499524 5051 21 13 0.619047619047619 0.00257374777271827
GO:BP GO:1901360 organic cyclic compound metabolic process 0.0126833918073596 6201 20 14 0.7 0.00225770037090792
GO:BP GO:0034660 ncRNA metabolic process 0.0130764252720822 493 18 4 0.222222222222222 0.00811359026369168
GO:BP GO:0009059 macromolecule biosynthetic process 0.0138847289184445 5114 21 13 0.619047619047619 0.00254204145482988
GO:BP GO:0071453 cellular response to oxygen levels 0.0143242029525132 240 17 3 0.176470588235294 0.0125
GO:BP GO:0006950 response to stress 0.0152182702589876 4170 12 8 0.666666666666667 0.00191846522781775
GO:BP GO:0044237 cellular metabolic process 0.0152182702589876 10871 22 20 0.909090909090909 0.00183975715205593
GO:BP GO:0016310 phosphorylation 0.015848441828931 2138 3 3 1 0.00140318054256314
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0180989162596774 363 13 3 0.230769230769231 0.00826446280991736
GO:BP GO:0044267 cellular protein metabolic process 0.0181320515634981 5229 26 15 0.576923076923077 0.00286861732644865
GO:BP GO:0006913 nucleocytoplasmic transport 0.0184099154949262 354 28 4 0.142857142857143 0.0112994350282486
GO:BP GO:0051169 nuclear transport 0.0187408280235011 357 28 4 0.142857142857143 0.0112044817927171
GO:BP GO:0034641 cellular nitrogen compound metabolic process 0.0194975387595022 6563 20 14 0.7 0.00213317080603383
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0203600085802901 6603 20 14 0.7 0.00212024837195214
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 0.0204489739834997 5017 20 12 0.6 0.00239186764999003
GO:BP GO:0043933 protein-containing complex subunit organization 0.0218872766963345 1963 19 7 0.368421052631579 0.00356597045338767
GO:BP GO:0042177 negative regulation of protein catabolic process 0.0231240774853428 125 42 3 0.0714285714285714 0.024
GO:BP GO:0031329 regulation of cellular catabolic process 0.0248642753961364 866 42 7 0.166666666666667 0.00808314087759815
GO:BP GO:0010498 proteasomal protein catabolic process 0.0255100999186753 491 24 4 0.166666666666667 0.00814663951120163
GO:BP GO:0016567 protein ubiquitination 0.0257838732715548 892 22 5 0.227272727272727 0.00560538116591928
GO:BP GO:0034220 ion transmembrane transport 0.027352891959943 1397 5 3 0.6 0.00214745884037223
GO:BP GO:0080135 regulation of cellular response to stress 0.0296807811154272 725 9 3 0.333333333333333 0.00413793103448276
GO:BP GO:0001666 response to hypoxia 0.0299792624956858 367 17 3 0.176470588235294 0.00817438692098093
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.0315499434140937 3087 3 3 1 0.000971817298347911
GO:BP GO:0006793 phosphorus metabolic process 0.0317291407367793 3114 3 3 1 0.000963391136801541
GO:BP GO:0036293 response to decreased oxygen levels 0.0317291407367793 382 17 3 0.176470588235294 0.00785340314136126
GO:BP GO:0019538 protein metabolic process 0.0326240775843899 5808 28 16 0.571428571428571 0.00275482093663912
GO:BP GO:0032446 protein modification by small protein conjugation 0.0331174061507218 973 22 5 0.227272727272727 0.00513874614594039
GO:BP GO:0019222 regulation of metabolic process 0.0334771392330423 7148 20 14 0.7 0.00195858981533296
GO:BP GO:0080134 regulation of response to stress 0.0338858042923647 1443 10 4 0.4 0.00277200277200277
GO:BP GO:0008380 RNA splicing 0.0338858042923647 456 15 3 0.2 0.00657894736842105
GO:BP GO:0070482 response to oxygen levels 0.0352649488001142 408 17 3 0.176470588235294 0.00735294117647059
GO:BP GO:0055085 transmembrane transport 0.0361727381763403 1635 5 3 0.6 0.0018348623853211
GO:BP GO:0008152 metabolic process 0.0365594504267862 11827 22 20 0.909090909090909 0.00169104591189651
GO:BP GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 0.0387461802316985 434 17 3 0.176470588235294 0.00691244239631336
GO:BP GO:0097190 apoptotic signaling pathway 0.0413572674872734 600 13 3 0.230769230769231 0.005
GO:BP GO:0030163 protein catabolic process 0.0413572674872734 974 24 5 0.208333333333333 0.00513347022587269
GO:BP GO:0044249 cellular biosynthetic process 0.0414157116906735 6154 21 13 0.619047619047619 0.00211244718882028
GO:BP GO:0009894 regulation of catabolic process 0.0440303676616896 1033 42 7 0.166666666666667 0.00677637947725073
GO:BP GO:0061013 regulation of mRNA catabolic process 0.0444846853938569 213 37 3 0.0810810810810811 0.0140845070422535
GO:BP GO:1901576 organic substance biosynthetic process 0.0446547731282048 6248 21 13 0.619047619047619 0.00208066581306018
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0464523868270515 8390 27 19 0.703703703703704 0.00226460071513707
GO:BP GO:0009058 biosynthetic process 0.0483610890454062 6340 21 13 0.619047619047619 0.00205047318611987
GO:BP GO:0030097 hemopoiesis 0.0491628040637464 928 27 5 0.185185185185185 0.00538793103448276
GO:CC GO:0022626 cytosolic ribosome 7.74795146915959e-14 109 28 10 0.357142857142857 0.0917431192660551
GO:CC GO:0044391 ribosomal subunit 1.60199489341792e-11 190 20 9 0.45 0.0473684210526316
GO:CC GO:0005840 ribosome 9.5942105558454e-11 245 28 10 0.357142857142857 0.0408163265306122
GO:CC GO:0022627 cytosolic small ribosomal subunit 2.74596645840067e-10 47 19 6 0.315789473684211 0.127659574468085
GO:CC GO:1990904 ribonucleoprotein complex 8.24136246220461e-10 688 20 11 0.55 0.0159883720930233
GO:CC GO:0015935 small ribosomal subunit 3.37680413434093e-09 75 19 6 0.315789473684211 0.08
GO:CC GO:0005925 focal adhesion 5.23958019644155e-06 420 20 7 0.35 0.0166666666666667
GO:CC GO:0030055 cell-substrate junction 5.23958019644155e-06 427 20 7 0.35 0.0163934426229508
GO:CC GO:0022625 cytosolic large ribosomal subunit 9.49073560938424e-06 57 20 4 0.2 0.0701754385964912
GO:CC GO:0005829 cytosol 4.48461176025107e-05 5303 20 16 0.8 0.0030171600980577
GO:CC GO:0042788 polysomal ribosome 4.48461176025107e-05 34 14 3 0.214285714285714 0.0882352941176471
GO:CC GO:0070062 extracellular exosome 5.36411988456764e-05 2176 35 15 0.428571428571429 0.00689338235294118
GO:CC GO:0032991 protein-containing complex 6.79314778404089e-05 5548 20 16 0.8 0.00288392213410238
GO:CC GO:0043230 extracellular organelle 6.79314778404089e-05 2263 20 11 0.55 0.00486080424215643
GO:CC GO:1903561 extracellular vesicle 6.79314778404089e-05 2261 20 11 0.55 0.00486510393631137
GO:CC GO:0015934 large ribosomal subunit 9.95196916552006e-05 118 20 4 0.2 0.0338983050847458
GO:CC GO:0070161 anchoring junction 0.000216656488329681 836 20 7 0.35 0.00837320574162679
GO:CC GO:0005844 polysome 0.000256578934656639 72 14 3 0.214285714285714 0.0416666666666667
GO:CC GO:0005791 rough endoplasmic reticulum 0.000414570570150308 86 14 3 0.214285714285714 0.0348837209302326
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.000768192111108366 11296 29 27 0.931034482758621 0.00239022662889518
GO:CC GO:0031974 membrane-enclosed lumen 0.000933505914359331 5565 19 14 0.736842105263158 0.00251572327044025
GO:CC GO:0043233 organelle lumen 0.000933505914359331 5565 19 14 0.736842105263158 0.00251572327044025
GO:CC GO:0005737 cytoplasm 0.000986487190664722 11911 20 20 1 0.00167912014104609
GO:CC GO:0005615 extracellular space 0.001259064073939 3594 24 13 0.541666666666667 0.00361713967723984
GO:CC GO:0070013 intracellular organelle lumen 0.00291534298488018 5402 19 13 0.684210526315789 0.00240651610514624
GO:CC GO:0043229 intracellular organelle 0.00479260400460984 12491 24 23 0.958333333333333 0.00184132575454327
GO:CC GO:0005740 mitochondrial envelope 0.0052827372870635 797 5 3 0.6 0.00376411543287327
GO:CC GO:0030054 cell junction 0.00581902412119412 2105 20 8 0.4 0.00380047505938242
GO:CC GO:0005634 nucleus 0.00581902412119412 7592 21 16 0.761904761904762 0.00210748155953635
GO:CC GO:0031982 vesicle 0.00667632217029724 4055 20 11 0.55 0.00271270036991369
GO:CC GO:0043227 membrane-bounded organelle 0.00704607270221429 12858 24 23 0.958333333333333 0.00178876963757972
GO:CC GO:0031981 nuclear lumen 0.00748779142130475 4444 19 11 0.578947368421053 0.00247524752475248
GO:CC GO:0005576 extracellular region 0.00791514968167721 4567 35 17 0.485714285714286 0.00372235603240639
GO:CC GO:0043228 non-membrane-bounded organelle 0.00791514968167721 5346 41 21 0.51219512195122 0.00392817059483726
GO:CC GO:0043292 contractile fiber 0.00791514968167721 240 39 4 0.102564102564103 0.0166666666666667
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.00791514968167721 5338 41 21 0.51219512195122 0.00393405769951293
GO:CC GO:0005622 intracellular anatomical structure 0.0110180155812452 14790 24 24 1 0.00162271805273834
GO:CC GO:0031967 organelle envelope 0.0110180155812452 1237 5 3 0.6 0.00242522231204527
GO:CC GO:0031975 envelope 0.0110180155812452 1237 5 3 0.6 0.00242522231204527
GO:CC GO:0005654 nucleoplasm 0.0119758473495359 4102 19 10 0.526315789473684 0.00243783520234032
GO:CC GO:0098796 membrane protein complex 0.012206875648659 1322 5 3 0.6 0.00226928895612708
GO:CC GO:0005783 endoplasmic reticulum 0.0155051591857924 1982 16 6 0.375 0.00302724520686176
GO:CC GO:0005739 mitochondrion 0.0191046399151706 1673 5 3 0.6 0.0017931858936043
GO:CC GO:0043226 organelle 0.0203248784662044 14008 24 23 0.958333333333333 0.00164191890348372
GO:CC GO:0030017 sarcomere 0.0246117532273286 208 39 3 0.0769230769230769 0.0144230769230769
GO:CC GO:0031966 mitochondrial membrane 0.0270924355169097 746 12 3 0.25 0.00402144772117962
GO:CC GO:0030016 myofibril 0.0301966444429734 231 39 3 0.0769230769230769 0.012987012987013
GO:MF GO:0003735 structural constituent of ribosome 1.0765869069636e-11 171 20 9 0.45 0.0526315789473684
GO:MF GO:0005198 structural molecule activity 1.49816095745508e-06 698 20 9 0.45 0.0128939828080229
GO:MF GO:0003723 RNA binding 5.6133691372967e-06 1943 20 12 0.6 0.00617601646937725
GO:MF GO:0003676 nucleic acid binding 0.00164728584816979 4276 20 13 0.65 0.00304022450888681
GO:MF GO:0015075 ion transmembrane transporter activity 0.0163566763012252 956 5 3 0.6 0.00313807531380753
GO:MF GO:0022857 transmembrane transporter activity 0.0195724491046877 1075 5 3 0.6 0.0027906976744186
GO:MF GO:0005215 transporter activity 0.0211962827154042 1185 5 3 0.6 0.00253164556962025
GO:MF GO:1901363 heterocyclic compound binding 0.0230722700574829 6228 20 13 0.65 0.00208734746307001
GO:MF GO:0097159 organic cyclic compound binding 0.0244972530882863 6309 20 13 0.65 0.00206054842288794
GO:MF GO:0042277 peptide binding 0.0272720782465912 314 22 3 0.136363636363636 0.00955414012738853
GO:MF GO:0033218 amide binding 0.0401180573755803 389 22 3 0.136363636363636 0.0077120822622108
HP HP:0030270 Elevated red cell adenosine deaminase level 7.63906146452356e-05 22 14 4 0.285714285714286 0.181818181818182
HP HP:0005532 Macrocytic dyserythropoietic anemia 7.63906146452356e-05 23 14 4 0.285714285714286 0.173913043478261
HP HP:0020118 Radial artery aplasia 7.63906146452356e-05 22 14 4 0.285714285714286 0.181818181818182
HP HP:0031640 Abnormal radial artery morphology 7.63906146452356e-05 22 14 4 0.285714285714286 0.181818181818182
HP HP:0012410 Pure red cell aplasia 7.63906146452356e-05 25 14 4 0.285714285714286 0.16
HP HP:0012133 Erythroid hypoplasia 7.63906146452356e-05 25 14 4 0.285714285714286 0.16
HP HP:0006758 Malignant genitourinary tract tumor 7.72443494147462e-05 26 14 4 0.285714285714286 0.153846153846154
HP HP:0040276 Adenocarcinoma of the colon 7.92015083840652e-05 27 14 4 0.285714285714286 0.148148148148148
HP HP:0001227 Abnormality of the thenar eminence 8.20092083902522e-05 29 14 4 0.285714285714286 0.137931034482759
HP HP:0040275 Adenocarcinoma of the large intestine 8.20092083902522e-05 30 14 4 0.285714285714286 0.133333333333333
HP HP:0030272 Abnormal erythrocyte enzyme level 8.20092083902522e-05 29 14 4 0.285714285714286 0.137931034482759
HP HP:0011904 Persistence of hemoglobin F 8.20092083902522e-05 30 14 4 0.285714285714286 0.133333333333333
HP HP:0001895 Normochromic anemia 8.67602613833435e-05 31 14 4 0.285714285714286 0.129032258064516
HP HP:0002669 Osteosarcoma 9.7437334234654e-05 33 14 4 0.285714285714286 0.121212121212121
HP HP:0001896 Reticulocytopenia 9.7437334234654e-05 33 14 4 0.285714285714286 0.121212121212121
HP HP:0040273 Adenocarcinoma of the intestines 0.000116467539258062 35 14 4 0.285714285714286 0.114285714285714
HP HP:0009944 Partial duplication of thumb phalanx 0.000137771739467538 37 14 4 0.285714285714286 0.108108108108108
HP HP:0012131 Abnormal number of erythroid precursors 0.000145165376942067 38 14 4 0.285714285714286 0.105263157894737
HP HP:0009999 Partial duplication of the phalanx of hand 0.000145319482031742 39 14 4 0.285714285714286 0.102564102564103
HP HP:0005518 Increased mean corpuscular volume 0.000145319482031742 39 14 4 0.285714285714286 0.102564102564103
HP HP:0001790 Nonimmune hydrops fetalis 0.00016979205105294 41 14 4 0.285714285714286 0.0975609756097561
HP HP:0009777 Absent thumb 0.00021609282060268 44 14 4 0.285714285714286 0.0909090909090909
HP HP:0025065 Abnormal mean corpuscular volume 0.000319726847695431 49 14 4 0.285714285714286 0.0816326530612245
HP HP:0001894 Thrombocytosis 0.000332451774701428 50 14 4 0.285714285714286 0.08
HP HP:0000912 Sprengel anomaly 0.000345694845809515 51 14 4 0.285714285714286 0.0784313725490196
HP HP:0009942 Duplication of thumb phalanx 0.000388099068364042 53 14 4 0.285714285714286 0.0754716981132075
HP HP:0011902 Abnormal hemoglobin 0.00040289917794546 54 14 4 0.285714285714286 0.0740740740740741
HP HP:0001972 Macrocytic anemia 0.000592633146409397 60 14 4 0.285714285714286 0.0666666666666667
HP HP:0001087 Developmental glaucoma 0.000740219942783142 64 14 4 0.285714285714286 0.0625
HP HP:0002672 Gastrointestinal carcinoma 0.0007575444941963 66 14 4 0.285714285714286 0.0606060606060606
HP HP:0006749 Malignant gastrointestinal tract tumors 0.0007575444941963 66 14 4 0.285714285714286 0.0606060606060606
HP HP:0004808 Acute myeloid leukemia 0.0007575444941963 67 14 4 0.285714285714286 0.0597014925373134
HP HP:0001199 Triphalangeal thumb 0.0007575444941963 67 14 4 0.285714285714286 0.0597014925373134
HP HP:0009380 Aplasia of the fingers 0.0007575444941963 66 14 4 0.285714285714286 0.0606060606060606
HP HP:0004312 Abnormal reticulocyte morphology 0.000978904518829453 72 14 4 0.285714285714286 0.0555555555555556
HP HP:0100273 Neoplasm of the colon 0.00130538848460126 78 14 4 0.285714285714286 0.0512820512820513
HP HP:0000085 Horseshoe kidney 0.00154621217931971 82 14 4 0.285714285714286 0.0487804878048781
HP HP:0001421 Abnormality of the musculature of the hand 0.00207532322588452 89 14 4 0.285714285714286 0.0449438202247191
HP HP:0010622 Neoplasm of the skeletal system 0.00240070108297222 93 14 4 0.285714285714286 0.043010752688172
HP HP:0001789 Hydrops fetalis 0.00254298784737003 95 14 4 0.285714285714286 0.0421052631578947
HP HP:0009778 Short thumb 0.00279989172746682 98 14 4 0.285714285714286 0.0408163265306122
HP HP:0002863 Myelodysplasia 0.00307266665772161 101 14 4 0.285714285714286 0.0396039603960396
HP HP:0002488 Acute leukemia 0.00323821058396709 103 14 4 0.285714285714286 0.0388349514563107
HP HP:0000294 Low anterior hairline 0.00328526509947794 104 14 4 0.285714285714286 0.0384615384615385
HP HP:0100834 Neoplasm of the large intestine 0.00345793143320218 106 14 4 0.285714285714286 0.0377358490566038
HP HP:0000465 Webbed neck 0.00404157109161087 111 14 4 0.285714285714286 0.036036036036036
HP HP:0001680 Coarctation of aorta 0.00423728243505488 113 14 4 0.285714285714286 0.0353982300884956
HP HP:0009601 Aplasia/Hypoplasia of the thumb 0.00617131622457825 126 14 4 0.285714285714286 0.0317460317460317
HP HP:0000519 Developmental cataract 0.00617131622457825 126 14 4 0.285714285714286 0.0317460317460317
HP HP:0008551 Microtia 0.00764733651296784 134 14 4 0.285714285714286 0.0298507462686567
HP HP:0000980 Pallor 0.00838368029762802 138 14 4 0.285714285714286 0.0289855072463768
HP HP:0008772 Aplasia/Hypoplasia of the external ear 0.00845076197328795 139 14 4 0.285714285714286 0.0287769784172662
HP HP:0001909 Leukemia 0.00923195906388367 143 14 4 0.285714285714286 0.027972027972028
HP HP:0008771 Aplasia/Hypoplasia of the ear 0.00930300638821406 144 14 4 0.285714285714286 0.0277777777777778
HP HP:0000782 Abnormal scapula morphology 0.00969754722684671 147 14 4 0.285714285714286 0.0272108843537415
HP HP:0000599 Abnormality of the frontal hairline 0.00969754722684671 147 14 4 0.285714285714286 0.0272108843537415
HP HP:0000185 Cleft soft palate 0.0129588225476493 161 14 4 0.285714285714286 0.0248447204968944
HP HP:0001875 Neutropenia 0.0131267993197892 163 14 4 0.285714285714286 0.0245398773006135
HP HP:0100542 Abnormal localization of kidney 0.0131267993197892 163 14 4 0.285714285714286 0.0245398773006135
HP HP:0100242 Sarcoma 0.0132615838716865 165 14 4 0.285714285714286 0.0242424242424242
HP HP:0010972 Anemia of inadequate production 0.0132615838716865 165 14 4 0.285714285714286 0.0242424242424242
HP HP:0000104 Renal agenesis 0.0147317880353611 171 14 4 0.285714285714286 0.0233918128654971
HP HP:0011991 Abnormal neutrophil count 0.0154787281258448 174 14 4 0.285714285714286 0.0229885057471264
HP HP:0009602 Abnormality of thumb phalanx 0.019913913433168 187 14 4 0.285714285714286 0.0213903743315508
HP HP:0001254 Lethargy 0.0199235062861018 189 14 4 0.285714285714286 0.0211640211640212
HP HP:0009774 Triangular shaped phalanges of the hand 0.0204244513504848 192 14 4 0.285714285714286 0.0208333333333333
HP HP:0410030 Cleft lip 0.0229261779472752 199 14 4 0.285714285714286 0.0201005025125628
HP HP:0001446 Abnormality of the musculature of the upper limbs 0.023625837710637 202 14 4 0.285714285714286 0.0198019801980198
HP HP:0100736 Abnormal soft palate morphology 0.0247232930422938 206 14 4 0.285714285714286 0.0194174757281553
HP HP:0009997 Duplication of phalanx of hand 0.024776211976073 208 14 4 0.285714285714286 0.0192307692307692
HP HP:0009142 Duplication of bones involving the upper extremities 0.024776211976073 209 14 4 0.285714285714286 0.0191387559808612
HP HP:0004275 Duplication of hand bones 0.024776211976073 209 14 4 0.285714285714286 0.0191387559808612
HP HP:0007700 Ocular anterior segment dysgenesis 0.0253163433841599 285 17 5 0.294117647058824 0.0175438596491228
HP HP:0009553 Abnormality of the hairline 0.025733698490329 213 14 4 0.285714285714286 0.0187793427230047
HP HP:0032309 Abnormal granulocyte count 0.025733698490329 214 14 4 0.285714285714286 0.0186915887850467
HP HP:0007379 Neoplasm of the genitourinary tract 0.025733698490329 214 14 4 0.285714285714286 0.0186915887850467
HP HP:0001882 Leukopenia 0.0268922130649966 218 14 4 0.285714285714286 0.018348623853211
HP HP:0001518 Small for gestational age 0.0270318368611146 219 14 4 0.285714285714286 0.0182648401826484
HP HP:0001629 Ventricular septal defect 0.0329291756960323 385 14 5 0.357142857142857 0.012987012987013
HP HP:0002250 Abnormal large intestine morphology 0.0333565817591592 235 14 4 0.285714285714286 0.0170212765957447
HP HP:0004377 Hematological neoplasm 0.0352106999505179 240 14 4 0.285714285714286 0.0166666666666667
HP HP:0010438 Abnormal ventricular septum morphology 0.0352106999505179 393 14 5 0.357142857142857 0.0127226463104326
HP HP:0001874 Abnormality of neutrophils 0.039329852662735 249 14 4 0.285714285714286 0.0160642570281124
HP HP:0011361 Congenital abnormal hair pattern 0.0411993451980942 253 14 4 0.285714285714286 0.0158102766798419
HP HP:0007378 Neoplasm of the gastrointestinal tract 0.0452454954336434 262 14 4 0.285714285714286 0.0152671755725191
KEGG KEGG:03010 Ribosome 2.38896526062114e-09 153 20 9 0.45 0.0588235294117647
KEGG KEGG:05171 Coronavirus disease - COVID-19 4.78954876478949e-08 231 20 9 0.45 0.038961038961039
MIRNA MIRNA:hsa-miR-320b hsa-miR-320b 0.0409532155858086 145 12 3 0.25 0.0206896551724138
MIRNA MIRNA:hsa-miR-92a-3p hsa-miR-92a-3p 0.0409532155858086 1404 20 8 0.4 0.0056980056980057
REAC REAC:R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 1.02070656620049e-12 113 20 10 0.5 0.0884955752212389
REAC REAC:R-HSA-72764 Eukaryotic Translation Termination 2.81649675448791e-12 94 20 9 0.45 0.0957446808510638
REAC REAC:R-HSA-156902 Peptide chain elongation 2.81649675448791e-12 90 20 9 0.45 0.1
REAC REAC:R-HSA-2408557 Selenocysteine synthesis 2.81649675448791e-12 94 20 9 0.45 0.0957446808510638
REAC REAC:R-HSA-192823 Viral mRNA Translation 2.81649675448791e-12 90 20 9 0.45 0.1
REAC REAC:R-HSA-156842 Eukaryotic Translation Elongation 2.81649675448791e-12 94 20 9 0.45 0.0957446808510638
REAC REAC:R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 2.93709173952941e-12 96 20 9 0.45 0.09375
REAC REAC:R-HSA-72689 Formation of a pool of free 40S subunits 4.01266783608947e-12 102 20 9 0.45 0.0882352941176471
REAC REAC:R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 4.01266783608947e-12 102 20 9 0.45 0.0882352941176471
REAC REAC:R-HSA-9010553 Regulation of expression of SLITs and ROBOs 7.04112311924903e-12 171 20 10 0.5 0.0584795321637427
REAC REAC:R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 7.76305586842295e-12 113 20 9 0.45 0.079646017699115
REAC REAC:R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 7.76305586842295e-12 112 20 9 0.45 0.0803571428571429
REAC REAC:R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 8.47291154429069e-12 116 20 9 0.45 0.0775862068965517
REAC REAC:R-HSA-927802 Nonsense-Mediated Decay (NMD) 8.47291154429069e-12 116 20 9 0.45 0.0775862068965517
REAC REAC:R-HSA-2408522 Selenoamino acid metabolism 8.55893698673881e-12 117 20 9 0.45 0.0769230769230769
REAC REAC:R-HSA-72737 Cap-dependent Translation Initiation 9.53443252861766e-12 120 20 9 0.45 0.075
REAC REAC:R-HSA-72613 Eukaryotic Translation Initiation 9.53443252861766e-12 120 20 9 0.45 0.075
REAC REAC:R-HSA-168273 Influenza Viral RNA Transcription and Replication 2.31465167885672e-11 133 20 9 0.45 0.0676691729323308
REAC REAC:R-HSA-376176 Signaling by ROBO receptors 4.08393736049933e-11 217 20 10 0.5 0.0460829493087558
REAC REAC:R-HSA-168255 Influenza Infection 7.04897410661409e-11 152 20 9 0.45 0.0592105263157895
REAC REAC:R-HSA-9711097 Cellular response to starvation 9.01109635741347e-11 157 20 9 0.45 0.0573248407643312
REAC REAC:R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 3.44690591922107e-10 183 20 9 0.45 0.0491803278688525
REAC REAC:R-HSA-8868773 rRNA processing in the nucleus and cytosol 5.32727430583747e-10 193 20 9 0.45 0.0466321243523316
REAC REAC:R-HSA-72766 Translation 6.22169239013148e-10 292 20 10 0.5 0.0342465753424658
REAC REAC:R-HSA-72312 rRNA processing 7.7215910743699e-10 203 20 9 0.45 0.0443349753694581
REAC REAC:R-HSA-8953854 Metabolism of RNA 4.37636719001876e-09 658 20 12 0.6 0.0182370820668693
REAC REAC:R-HSA-71291 Metabolism of amino acids and derivatives 5.39833398264596e-09 368 20 10 0.5 0.0271739130434783
REAC REAC:R-HSA-2262752 Cellular responses to stress 1.15535339387707e-08 546 20 11 0.55 0.0201465201465201
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 1.46065070023888e-08 560 20 11 0.55 0.0196428571428571
REAC REAC:R-HSA-422475 Axon guidance 2.35034964559478e-07 549 20 10 0.5 0.0182149362477231
REAC REAC:R-HSA-9675108 Nervous system development 3.48379276680065e-07 574 20 10 0.5 0.0174216027874564
REAC REAC:R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 3.74445571444178e-07 52 19 5 0.263157894736842 0.0961538461538462
REAC REAC:R-HSA-72702 Ribosomal scanning and start codon recognition 6.54364155666055e-07 59 19 5 0.263157894736842 0.0847457627118644
REAC REAC:R-HSA-5663205 Infectious disease 6.54364155666055e-07 815 20 11 0.55 0.0134969325153374
REAC REAC:R-HSA-72649 Translation initiation complex formation 6.54364155666055e-07 59 19 5 0.263157894736842 0.0847457627118644
REAC REAC:R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 6.9325218126016e-07 60 19 5 0.263157894736842 0.0833333333333333
REAC REAC:R-HSA-1266738 Developmental Biology 9.62527431866655e-05 1069 20 10 0.5 0.00935453695042095
REAC REAC:R-HSA-9609507 Protein localization 0.000260932982070314 158 12 4 0.333333333333333 0.0253164556962025
REAC REAC:R-HSA-1643685 Disease 0.000279222055163616 1509 20 11 0.55 0.00728959575878065
REAC REAC:R-HSA-392499 Metabolism of proteins 0.000535398532089071 1961 20 12 0.6 0.00611932687404386
REAC REAC:R-HSA-1430728 Metabolism 0.00091374753620125 2070 20 12 0.6 0.00579710144927536
REAC REAC:R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) 0.00255393897422776 80 17 3 0.176470588235294 0.0375
REAC REAC:R-HSA-1236974 ER-Phagosome pathway 0.00273135498897483 83 17 3 0.176470588235294 0.036144578313253
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 0.0040882442538228 99 17 3 0.176470588235294 0.0303030303030303
REAC REAC:R-HSA-162909 Host Interactions of HIV factors 0.00765264066905144 125 17 3 0.176470588235294 0.024
REAC REAC:R-HSA-983705 Signaling by the B Cell Receptor (BCR) 0.0158971747853162 164 17 3 0.176470588235294 0.0182926829268293
REAC REAC:R-HSA-162906 HIV Infection 0.0219960320627962 226 17 3 0.176470588235294 0.0132743362831858
REAC REAC:R-HSA-983169 Class I MHC mediated antigen processing & presentation 0.0247648237975934 370 22 4 0.181818181818182 0.0108108108108108
REAC REAC:R-HSA-3700989 Transcriptional Regulation by TP53 0.0254237080629725 360 12 3 0.25 0.00833333333333333
REAC REAC:R-HSA-157118 Signaling by NOTCH 0.0285664878209334 197 23 3 0.130434782608696 0.0152284263959391
REAC REAC:R-HSA-1280218 Adaptive Immune System 0.0459390644538796 800 22 5 0.227272727272727 0.00625
REAC REAC:R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 0.0486458461762744 308 22 3 0.136363636363636 0.00974025974025974
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.0486458461762744 446 27 4 0.148148148148148 0.00896860986547085
TF TF:M11392_1 Factor: Erg; motif: NACCGGAARYN; match class: 1 0.00139152880742125 3233 14 11 0.785714285714286 0.00340241261985772
TF TF:M11400_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.00139152880742125 4201 14 12 0.857142857142857 0.00285646274696501
TF TF:M11404_1 Factor: Fli-1; motif: NACCGGAARTN; match class: 1 0.00372484199256628 3171 13 10 0.769230769230769 0.00315357931251971
TF TF:M03975_1 Factor: ERG; motif: ACCGGAARTN; match class: 1 0.00447456615775422 4024 16 12 0.75 0.00298210735586481
TF TF:M11396_1 Factor: Erg; motif: NACCGGAARTN; match class: 1 0.00447456615775422 4963 14 12 0.857142857142857 0.00241789240378803
TF TF:M03988_1 Factor: FLI1; motif: ACCGGAARTN; match class: 1 0.013652279559833 2950 13 9 0.692307692307692 0.00305084745762712
TF TF:M03977_1 Factor: ETS1; motif: ACCGGAARYN; match class: 1 0.0146233295903938 4677 16 12 0.75 0.00256574727389352
TF TF:M00025_1 Factor: Elk-1; motif: NNNNCCGGAARTNN; match class: 1 0.0146233295903938 4639 16 12 0.75 0.00258676438887691
TF TF:M10627_1 Factor: NKX3A; motif: NCCACTTANN; match class: 1 0.0227948740106958 212 7 3 0.428571428571429 0.0141509433962264
TF TF:M02062_1 Factor: Erg; motif: ACCGGAAGTN; match class: 1 0.0227948740106958 2718 12 8 0.666666666666667 0.00294334069168506
TF TF:M08913_1 Factor: FLI-1; motif: NAYTTCCGGT; match class: 1 0.0240905446543128 3055 14 9 0.642857142857143 0.00294599018003273
TF TF:M04457 Factor: ESRRA; motif: AAGGTCATNCAAGGTCA 0.0243632697262583 3550 18 11 0.611111111111111 0.00309859154929577
TF TF:M04498_1 Factor: VDR; motif: GRGTTCATYGRGTTCA; match class: 1 0.0243632697262583 876 6 4 0.666666666666667 0.0045662100456621
TF TF:M11452 Factor: Elf-1; motif: NANGCGGAAGTR 0.0359067259158975 6276 20 15 0.75 0.00239005736137667
TF TF:M01752_1 Factor: ERG; motif: ACCGGAART; match class: 1 0.0359068031820365 3705 13 9 0.692307692307692 0.00242914979757085
TF TF:M02062 Factor: Erg; motif: ACCGGAAGTN 0.0359068031820365 8056 27 21 0.777777777777778 0.00260675273088381
TF TF:M02071_1 Factor: ETV7; motif: NCCGGAANNN; match class: 1 0.0428427911811861 4465 14 10 0.714285714285714 0.00223964165733483
TF TF:M10636 Factor: Nkx2-3; motif: NSCACTTNNN 0.0428427911811861 3099 47 18 0.382978723404255 0.00580832526621491
TF TF:M11422 Factor: Erm; motif: NRCMGGAAGTN 0.0439476256311277 4669 16 11 0.6875 0.0023559648747055
TF TF:M01770_1 Factor: XBP-1; motif: WNNGMCACGTC; match class: 1 0.0439476256311277 4554 14 10 0.714285714285714 0.00219587176108915
TF TF:M10644 Factor: Homeobox; motif: NCAMTTANC 0.0451964483441182 3682 9 7 0.777777777777778 0.00190114068441065
TF TF:M11012 Factor: islet1; motif: SCAMTTAN 0.0451964483441182 6170 9 8 0.888888888888889 0.00129659643435981
TF TF:M11012_1 Factor: islet1; motif: SCAMTTAN; match class: 1 0.0451964483441182 1305 7 4 0.571428571428571 0.00306513409961686
TF TF:M09608_1 Factor: Erg; motif: NNACCGGAARTSN; match class: 1 0.0451964483441182 2389 4 4 1 0.00167434072833822
TF TF:M00965 Factor: LXR,; motif: YGAMCTNNASTRACCYN 0.0451964483441182 3793 18 10 0.555555555555556 0.00263643553915107
TF TF:M11447 Factor: Elf-1; motif: NAMCCGGAAGTN 0.0451964483441182 7703 27 20 0.740740740740741 0.00259639101648708
TF TF:M11448 Factor: Elf-1; motif: NANGCGGAAGTN 0.0451964483441182 7600 22 17 0.772727272727273 0.00223684210526316
TF TF:M11382 Factor: ESE-1; motif: NWTRCGGAWGCN 0.0451964483441182 10339 24 21 0.875 0.002031144211239
TF TF:M02059_1 Factor: ELK-1; motif: ACCGGAAGTN; match class: 1 0.0451964483441182 3759 12 8 0.666666666666667 0.00212822559191274
TF TF:M11435 Factor: Elk-1; motif: NNCCGGAAGTN 0.0451964483441182 11728 24 22 0.916666666666667 0.00187585266030014
TF TF:M04457_1 Factor: ESRRA; motif: AAGGTCATNCAAGGTCA; match class: 1 0.0451964483441182 389 7 3 0.428571428571429 0.0077120822622108
TF TF:M09817_1 Factor: PAX5; motif: RNGCGTGACCNN; match class: 1 0.0451964483441182 6170 12 10 0.833333333333333 0.00162074554294976
TF TF:M04108 Factor: RUNX2; motif: WAACCGCAA 0.0451964483441182 1174 18 6 0.333333333333333 0.00511073253833049
TF TF:M04059 Factor: NRF-1; motif: YGCGCATGCGCN 0.0451964483441182 1471 19 7 0.368421052631579 0.00475866757307954
TF TF:M11276 Factor: XBP-1; motif: NNMCACGTCANN 0.0451964483441182 551 15 4 0.266666666666667 0.00725952813067151
TF TF:M01482_1 Factor: Nkx3-2; motif: NNNAACCACTTAANNAN; match class: 1 0.0451964483441182 465 7 3 0.428571428571429 0.00645161290322581
TF TF:M10627 Factor: NKX3A; motif: NCCACTTANN 0.0451964483441182 2557 9 6 0.666666666666667 0.00234649980445835
TF TF:M10636_1 Factor: Nkx2-3; motif: NSCACTTNNN; match class: 1 0.0451964483441182 296 23 4 0.173913043478261 0.0135135135135135
TF TF:M02099 Factor: MITF; motif: CATGTGM 0.0451964483441182 3214 10 7 0.7 0.00217797137523335
TF TF:M10992 Factor: lmx1b; motif: NNNTTAATTAN 0.0451964483441182 447 8 3 0.375 0.00671140939597315
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.0478227571264537 10116 31 25 0.806451612903226 0.00247133254250692
TF TF:M11022 Factor: IRX2a; motif: ACRYGNNNNACRYGT 0.0485102148035876 9487 20 17 0.85 0.00179192579319068
TF TF:M08913 Factor: FLI-1; motif: NAYTTCCGGT 0.0492036779197379 8322 27 20 0.740740740740741 0.00240326844508532
TF TF:M11535_1 Factor: E2F-4; motif: TTTTGGCGCCAWWN; match class: 1 0.0492036779197379 6532 18 13 0.722222222222222 0.00199020208205756
TF TF:M03966 Factor: ELF1; motif: AACCCGGAAGTR 0.0492036779197379 6610 30 19 0.633333333333333 0.00287443267776097
TF TF:M11451 Factor: Elf-1; motif: NANCCGGAAGTN 0.0492036779197379 6886 27 18 0.666666666666667 0.00261399941911124
TF TF:M11015_1 Factor: ISL2; motif: SCACTTAN; match class: 1 0.0492036779197379 579 7 3 0.428571428571429 0.00518134715025907
TF TF:M00394 Factor: Msx-1; motif: CNGTAWNTG 0.0492036779197379 8904 9 9 1 0.00101078167115903
WP WP:WP477 Cytoplasmic Ribosomal Proteins 1.50446657702288e-11 90 20 9 0.45 0.1

pEpiTp14 transcription factor target enrichment of top program genes

TF enrichment of pEpiTp14
Possible regulators of activation of pEpiTp14 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.