pTNI05 program activity among T/NK/ILC cells

Activation of pTNI05
pTNI05 gene program activation in T/NK/ILC cells.
Gene program activation of pTNI05 by different cell subtypes
pTNI05 gene program activation among cells of different subtypes (T/NK/ILC cells).

pTNI05 top program genes

Top genes of pTNI05 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pTNI05 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pTNI05
pTNI05 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0042110 T cell activation 3.40014217654604e-05 489 75 14 0.186666666666667 0.0286298568507157
GO:BP GO:0051249 regulation of lymphocyte activation 3.50739135413448e-05 518 75 14 0.186666666666667 0.027027027027027
GO:BP GO:0051251 positive regulation of lymphocyte activation 4.19631539882149e-05 365 53 10 0.188679245283019 0.0273972602739726
GO:BP GO:0070661 leukocyte proliferation 4.19631539882149e-05 325 64 10 0.15625 0.0307692307692308
GO:BP GO:0046651 lymphocyte proliferation 4.19631539882149e-05 294 64 10 0.15625 0.0340136054421769
GO:BP GO:0046649 lymphocyte activation 4.19631539882149e-05 771 53 13 0.245283018867925 0.0168612191958495
GO:BP GO:0002694 regulation of leukocyte activation 4.19631539882149e-05 610 53 12 0.226415094339623 0.019672131147541
GO:BP GO:0022409 positive regulation of cell-cell adhesion 4.19631539882149e-05 284 54 9 0.166666666666667 0.0316901408450704
GO:BP GO:0050863 regulation of T cell activation 4.19631539882149e-05 337 75 11 0.146666666666667 0.0326409495548961
GO:BP GO:0032943 mononuclear cell proliferation 4.19631539882149e-05 297 64 10 0.15625 0.0336700336700337
GO:BP GO:0032944 regulation of mononuclear cell proliferation 4.19631539882149e-05 232 64 9 0.140625 0.0387931034482759
GO:BP GO:0002698 negative regulation of immune effector process 4.19631539882149e-05 125 38 6 0.157894736842105 0.048
GO:BP GO:0002683 negative regulation of immune system process 4.19631539882149e-05 420 38 9 0.236842105263158 0.0214285714285714
GO:BP GO:0042129 regulation of T cell proliferation 4.19631539882149e-05 176 64 8 0.125 0.0454545454545455
GO:BP GO:0050870 positive regulation of T cell activation 4.19631539882149e-05 219 53 8 0.150943396226415 0.0365296803652968
GO:BP GO:0050670 regulation of lymphocyte proliferation 4.19631539882149e-05 230 64 9 0.140625 0.0391304347826087
GO:BP GO:0070663 regulation of leukocyte proliferation 4.19631539882149e-05 251 64 9 0.140625 0.0358565737051793
GO:BP GO:0002696 positive regulation of leukocyte activation 4.53921012860675e-05 412 53 10 0.188679245283019 0.0242718446601942
GO:BP GO:0030217 T cell differentiation 4.70311147625287e-05 260 64 9 0.140625 0.0346153846153846
GO:BP GO:0050865 regulation of cell activation 4.70311147625287e-05 655 53 12 0.226415094339623 0.0183206106870229
GO:BP GO:0050867 positive regulation of cell activation 5.06612376020235e-05 424 53 10 0.188679245283019 0.0235849056603774
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 6.34703802762966e-05 241 53 8 0.150943396226415 0.033195020746888
GO:BP GO:0045321 leukocyte activation 6.40763745585736e-05 1332 64 18 0.28125 0.0135135135135135
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 6.67450897242159e-05 338 53 9 0.169811320754717 0.0266272189349112
GO:BP GO:0042098 T cell proliferation 7.29131183066808e-05 205 64 8 0.125 0.0390243902439024
GO:BP GO:0022407 regulation of cell-cell adhesion 7.6473589621454e-05 445 54 10 0.185185185185185 0.0224719101123595
GO:BP GO:0046631 alpha-beta T cell activation 8.77686617557564e-05 155 38 6 0.157894736842105 0.0387096774193548
GO:BP GO:0050777 negative regulation of immune response 9.1239248568355e-05 157 38 6 0.157894736842105 0.0382165605095541
GO:BP GO:0030155 regulation of cell adhesion 0.000106371150699382 748 92 16 0.173913043478261 0.0213903743315508
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.000110678540727293 375 83 11 0.132530120481928 0.0293333333333333
GO:BP GO:0048872 homeostasis of number of cells 0.000138916260261084 261 7 4 0.571428571428571 0.0153256704980843
GO:BP GO:1903131 mononuclear cell differentiation 0.000183970474558884 430 49 9 0.183673469387755 0.0209302325581395
GO:BP GO:0046634 regulation of alpha-beta T cell activation 0.000203372344649464 102 38 5 0.131578947368421 0.0490196078431373
GO:BP GO:0035710 CD4-positive, alpha-beta T cell activation 0.000217278137611909 104 38 5 0.131578947368421 0.0480769230769231
GO:BP GO:0001775 cell activation 0.000224133901900311 1495 64 18 0.28125 0.0120401337792642
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.000285088810878681 141 53 6 0.113207547169811 0.0425531914893617
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.000288976994931428 142 53 6 0.113207547169811 0.0422535211267606
GO:BP GO:0045582 positive regulation of T cell differentiation 0.000364716849424589 91 49 5 0.102040816326531 0.0549450549450549
GO:BP GO:0045785 positive regulation of cell adhesion 0.000372457383647227 437 83 11 0.132530120481928 0.0251716247139588
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.00044030622180859 155 53 6 0.113207547169811 0.0387096774193548
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.00044030622180859 325 113 11 0.0973451327433628 0.0338461538461538
GO:BP GO:0030098 lymphocyte differentiation 0.00047015081705996 376 64 9 0.140625 0.023936170212766
GO:BP GO:0001911 negative regulation of leukocyte mediated cytotoxicity 0.000517734487634769 20 35 3 0.0857142857142857 0.15
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 0.000567975324825797 104 49 5 0.102040816326531 0.0480769230769231
GO:BP GO:0045619 regulation of lymphocyte differentiation 0.000567975324825797 180 49 6 0.122448979591837 0.0333333333333333
GO:BP GO:0007155 cell adhesion 0.000623086272016826 1492 104 23 0.221153846153846 0.0154155495978552
GO:BP GO:0022610 biological adhesion 0.000657057908733338 1499 104 23 0.221153846153846 0.0153435623749166
GO:BP GO:1902105 regulation of leukocyte differentiation 0.000672796871025574 288 49 7 0.142857142857143 0.0243055555555556
GO:BP GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 0.000672796871025574 67 38 4 0.105263157894737 0.0597014925373134
GO:BP GO:0045663 positive regulation of myoblast differentiation 0.000717257457674393 23 116 4 0.0344827586206897 0.173913043478261
GO:BP GO:0042102 positive regulation of T cell proliferation 0.000717257457674393 104 53 5 0.0943396226415094 0.0480769230769231
GO:BP GO:0031342 negative regulation of cell killing 0.000717257457674393 24 35 3 0.0857142857142857 0.125
GO:BP GO:0071345 cellular response to cytokine stimulus 0.000732545700654575 1132 38 11 0.289473684210526 0.00971731448763251
GO:BP GO:0002521 leukocyte differentiation 0.000756790681556056 550 49 9 0.183673469387755 0.0163636363636364
GO:BP GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.000800801679462226 152 38 5 0.131578947368421 0.0328947368421053
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.000800801679462226 360 113 11 0.0973451327433628 0.0305555555555556
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.000892765588439689 156 38 5 0.131578947368421 0.032051282051282
GO:BP GO:0042542 response to hydrogen peroxide 0.000942046983693579 150 7 3 0.428571428571429 0.02
GO:BP GO:0046640 regulation of alpha-beta T cell proliferation 0.00102098827736269 35 28 3 0.107142857142857 0.0857142857142857
GO:BP GO:0002819 regulation of adaptive immune response 0.0011806318669354 167 38 5 0.131578947368421 0.029940119760479
GO:BP GO:0046633 alpha-beta T cell proliferation 0.00125697608316814 38 28 3 0.107142857142857 0.0789473684210526
GO:BP GO:0009605 response to external stimulus 0.00125697608316814 2944 41 18 0.439024390243902 0.00611413043478261
GO:BP GO:0034097 response to cytokine 0.00129264063135298 1226 38 11 0.289473684210526 0.00897226753670473
GO:BP GO:0031341 regulation of cell killing 0.00132176808419567 93 35 4 0.114285714285714 0.043010752688172
GO:BP GO:0002456 T cell mediated immunity 0.00157838204530531 98 35 4 0.114285714285714 0.0408163265306122
GO:BP GO:0001914 regulation of T cell mediated cytotoxicity 0.00171952540409161 35 35 3 0.0857142857142857 0.0857142857142857
GO:BP GO:0098609 cell-cell adhesion 0.00171952540409161 894 92 15 0.16304347826087 0.0167785234899329
GO:BP GO:0002695 negative regulation of leukocyte activation 0.00176955265838171 188 38 5 0.131578947368421 0.0265957446808511
GO:BP GO:0032101 regulation of response to external stimulus 0.00176955265838171 1051 38 10 0.263157894736842 0.00951474785918173
GO:BP GO:2000515 negative regulation of CD4-positive, alpha-beta T cell activation 0.00176955265838171 33 38 3 0.0789473684210526 0.0909090909090909
GO:BP GO:0002684 positive regulation of immune system process 0.00177784487622648 1065 53 12 0.226415094339623 0.0112676056338028
GO:BP GO:0001816 cytokine production 0.00184762029294155 844 38 9 0.236842105263158 0.0106635071090047
GO:BP GO:0030595 leukocyte chemotaxis 0.00193259171750159 227 77 7 0.0909090909090909 0.0308370044052863
GO:BP GO:0045580 regulation of T cell differentiation 0.00205746058325716 152 49 5 0.102040816326531 0.0328947368421053
GO:BP GO:0023051 regulation of signaling 0.00221762968286605 3578 131 45 0.343511450381679 0.0125768585802124
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.00231394892056777 157 49 5 0.102040816326531 0.0318471337579618
GO:BP GO:1903708 positive regulation of hemopoiesis 0.00231394892056777 157 49 5 0.102040816326531 0.0318471337579618
GO:BP GO:0002520 immune system development 0.00245279753332296 1020 49 11 0.224489795918367 0.0107843137254902
GO:BP GO:0001913 T cell mediated cytotoxicity 0.00253199158302035 42 35 3 0.0857142857142857 0.0714285714285714
GO:BP GO:0000302 response to reactive oxygen species 0.00254894389569912 237 7 3 0.428571428571429 0.0126582278481013
GO:BP GO:0050866 negative regulation of cell activation 0.00254894389569912 211 38 5 0.131578947368421 0.023696682464455
GO:BP GO:0002682 regulation of immune system process 0.00254894389569912 1617 38 12 0.315789473684211 0.00742115027829314
GO:BP GO:0002707 negative regulation of lymphocyte mediated immunity 0.00259747801509085 43 35 3 0.0857142857142857 0.0697674418604651
GO:BP GO:0032103 positive regulation of response to external stimulus 0.00274219384005238 513 38 7 0.184210526315789 0.01364522417154
GO:BP GO:0046636 negative regulation of alpha-beta T cell activation 0.00281534896983351 41 38 3 0.0789473684210526 0.0731707317073171
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.00293167621845505 516 113 12 0.106194690265487 0.0232558139534884
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00312229722552683 363 38 6 0.157894736842105 0.0165289256198347
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 0.00312229722552683 99 17 3 0.176470588235294 0.0303030303030303
GO:BP GO:0070887 cellular response to chemical stimulus 0.00312229722552683 3393 60 24 0.4 0.00707338638373121
GO:BP GO:0010646 regulation of cell communication 0.00312229722552683 3543 131 44 0.33587786259542 0.0124188540784646
GO:BP GO:0042773 ATP synthesis coupled electron transport 0.003140590550023 100 17 3 0.176470588235294 0.03
GO:BP GO:0010033 response to organic substance 0.00332865374852423 3412 53 22 0.415094339622642 0.00644783118405627
GO:BP GO:0036037 CD8-positive, alpha-beta T cell activation 0.00338500651485389 27 64 3 0.046875 0.111111111111111
GO:BP GO:0002376 immune system process 0.00338500651485389 3278 41 18 0.439024390243902 0.00549115314215985
GO:BP GO:0030855 epithelial cell differentiation 0.00338500651485389 798 7 4 0.571428571428571 0.0050125313283208
GO:BP GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00346415074512047 46 38 3 0.0789473684210526 0.0652173913043478
GO:BP GO:0002704 negative regulation of leukocyte mediated immunity 0.00352587259597734 51 35 3 0.0857142857142857 0.0588235294117647
GO:BP GO:0050868 negative regulation of T cell activation 0.00352587259597734 123 38 4 0.105263157894737 0.032520325203252
GO:BP GO:0071310 cellular response to organic substance 0.00352587259597734 2776 64 22 0.34375 0.00792507204610951
GO:BP GO:0048731 system development 0.00352939767452143 5052 7 7 1 0.00138558986539984
GO:BP GO:1903706 regulation of hemopoiesis 0.00360038447737912 424 49 7 0.142857142857143 0.0165094339622642
GO:BP GO:0051094 positive regulation of developmental process 0.00369954389911804 1341 41 11 0.268292682926829 0.00820283370618941
GO:BP GO:0006874 cellular calcium ion homeostasis 0.00374072654905095 460 113 11 0.0973451327433628 0.0239130434782609
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00377121715586007 1455 51 13 0.254901960784314 0.00893470790378007
GO:BP GO:0046635 positive regulation of alpha-beta T cell activation 0.0038310908569669 67 28 3 0.107142857142857 0.0447761194029851
GO:BP GO:0030097 hemopoiesis 0.00396732935390203 928 49 10 0.204081632653061 0.0107758620689655
GO:BP GO:0042127 regulation of cell population proliferation 0.00396732935390203 1774 7 5 0.714285714285714 0.0028184892897407
GO:BP GO:0045595 regulation of cell differentiation 0.00396732935390203 1679 57 15 0.263157894736842 0.00893388921977368
GO:BP GO:0048584 positive regulation of response to stimulus 0.00403826739099435 2344 38 14 0.368421052631579 0.00597269624573379
GO:BP GO:0002820 negative regulation of adaptive immune response 0.00403826739099435 51 38 3 0.0789473684210526 0.0588235294117647
GO:BP GO:0022904 respiratory electron transport chain 0.00404222018379166 117 17 3 0.176470588235294 0.0256410256410256
GO:BP GO:2000026 regulation of multicellular organismal development 0.00406275778873982 1447 52 13 0.25 0.00898410504492052
GO:BP GO:0055074 calcium ion homeostasis 0.0041401255609769 472 113 11 0.0973451327433628 0.0233050847457627
GO:BP GO:0009607 response to biotic stimulus 0.0041401255609769 1626 41 12 0.292682926829268 0.00738007380073801
GO:BP GO:0051336 regulation of hydrolase activity 0.00447247807417887 1321 50 12 0.24 0.00908402725208176
GO:BP GO:0050790 regulation of catalytic activity 0.00463116245976027 2545 53 18 0.339622641509434 0.00707269155206287
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.00488445238691197 142 38 4 0.105263157894737 0.028169014084507
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.00488445238691197 966 49 10 0.204081632653061 0.010351966873706
GO:BP GO:0001817 regulation of cytokine production 0.00488445238691197 806 38 8 0.210526315789474 0.00992555831265509
GO:BP GO:0048585 negative regulation of response to stimulus 0.00488445238691197 1733 57 15 0.263157894736842 0.00865551067512983
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0049817380367391 810 38 8 0.210526315789474 0.00987654320987654
GO:BP GO:0055065 metal ion homeostasis 0.0049817380367391 667 97 12 0.123711340206186 0.0179910044977511
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.0058207126491197 497 113 11 0.0973451327433628 0.0221327967806841
GO:BP GO:0002686 negative regulation of leukocyte migration 0.0058207126491197 47 122 4 0.0327868852459016 0.0851063829787234
GO:BP GO:0007275 multicellular organism development 0.0058207126491197 5613 7 7 1 0.00124710493497239
GO:BP GO:0002706 regulation of lymphocyte mediated immunity 0.0058207126491197 151 38 4 0.105263157894737 0.0264900662251656
GO:BP GO:0042982 amyloid precursor protein metabolic process 0.00592435243938011 96 60 4 0.0666666666666667 0.0416666666666667
GO:BP GO:0048856 anatomical structure development 0.00597807324828798 6106 54 31 0.574074074074074 0.00507697346871929
GO:BP GO:2000106 regulation of leukocyte apoptotic process 0.00624527024286244 82 72 4 0.0555555555555556 0.0487804878048781
GO:BP GO:0071674 mononuclear cell migration 0.00624527024286244 191 122 7 0.0573770491803279 0.0366492146596859
GO:BP GO:0008283 cell population proliferation 0.00627031647618086 2054 7 5 0.714285714285714 0.00243427458617332
GO:BP GO:0006875 cellular metal ion homeostasis 0.00633819639795988 593 97 11 0.11340206185567 0.0185497470489039
GO:BP GO:0090022 regulation of neutrophil chemotaxis 0.00637213521466089 32 77 3 0.038961038961039 0.09375
GO:BP GO:0050793 regulation of developmental process 0.00642130628274259 2605 41 15 0.365853658536585 0.00575815738963532
GO:BP GO:0045661 regulation of myoblast differentiation 0.00642130628274259 52 116 4 0.0344827586206897 0.0769230769230769
GO:BP GO:0001906 cell killing 0.00642130628274259 175 35 4 0.114285714285714 0.0228571428571429
GO:BP GO:0002252 immune effector process 0.00642130628274259 1309 39 10 0.256410256410256 0.00763941940412529
GO:BP GO:0060326 cell chemotaxis 0.00642130628274259 310 77 7 0.0909090909090909 0.0225806451612903
GO:BP GO:0006119 oxidative phosphorylation 0.00645308603322791 151 17 3 0.176470588235294 0.0198675496688742
GO:BP GO:0010628 positive regulation of gene expression 0.00647104717025677 1160 60 12 0.2 0.0103448275862069
GO:BP GO:0002697 regulation of immune effector process 0.00654117323211075 461 38 6 0.157894736842105 0.0130151843817787
GO:BP GO:0023052 signaling 0.00676923301964537 6810 54 33 0.611111111111111 0.00484581497797357
GO:BP GO:0001910 regulation of leukocyte mediated cytotoxicity 0.00689253082643746 74 35 3 0.0857142857142857 0.0405405405405405
GO:BP GO:0002709 regulation of T cell mediated immunity 0.00689253082643746 74 35 3 0.0857142857142857 0.0405405405405405
GO:BP GO:0050920 regulation of chemotaxis 0.0070090876390072 226 77 6 0.0779220779220779 0.0265486725663717
GO:BP GO:0010035 response to inorganic substance 0.0070090876390072 575 12 4 0.333333333333333 0.00695652173913044
GO:BP GO:0007154 cell communication 0.0070090876390072 6829 54 33 0.611111111111111 0.0048323326987846
GO:BP GO:0071676 negative regulation of mononuclear cell migration 0.00717923657504478 22 122 3 0.0245901639344262 0.136363636363636
GO:BP GO:0048583 regulation of response to stimulus 0.00726705004178765 4278 53 24 0.452830188679245 0.00561009817671809
GO:BP GO:0042221 response to chemical 0.00799569212267601 4781 54 26 0.481481481481481 0.00543819284668479
GO:BP GO:0002250 adaptive immune response 0.00818092899090841 689 38 7 0.184210526315789 0.0101596516690856
GO:BP GO:0007399 nervous system development 0.00858570699255385 2449 131 32 0.244274809160305 0.0130665577786852
GO:BP GO:0006979 response to oxidative stress 0.00881253252855523 466 7 3 0.428571428571429 0.00643776824034335
GO:BP GO:2000145 regulation of cell motility 0.00909293692676989 1061 130 18 0.138461538461538 0.0169651272384543
GO:BP GO:0010941 regulation of cell death 0.00924024345167141 1720 38 11 0.289473684210526 0.0063953488372093
GO:BP GO:0022900 electron transport chain 0.00927472462968343 180 17 3 0.176470588235294 0.0166666666666667
GO:BP GO:0051707 response to other organism 0.00950189699449021 1592 41 11 0.268292682926829 0.00690954773869347
GO:BP GO:0030514 negative regulation of BMP signaling pathway 0.00950189699449021 53 57 3 0.0526315789473684 0.0566037735849057
GO:BP GO:0008285 negative regulation of cell population proliferation 0.00950686634702989 790 118 14 0.11864406779661 0.0177215189873418
GO:BP GO:0043207 response to external biotic stimulus 0.00950686634702989 1594 41 11 0.268292682926829 0.006900878293601
GO:BP GO:0002440 production of molecular mediator of immune response 0.00960753231891592 189 38 4 0.105263157894737 0.0211640211640212
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00960753231891592 717 38 7 0.184210526315789 0.0097629009762901
GO:BP GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 0.00963375685392444 32 97 3 0.0309278350515464 0.09375
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.00963375685392444 190 38 4 0.105263157894737 0.0210526315789474
GO:BP GO:0055080 cation homeostasis 0.00963375685392444 750 97 12 0.123711340206186 0.016
GO:BP GO:0002263 cell activation involved in immune response 0.00963375685392444 721 38 7 0.184210526315789 0.00970873786407767
GO:BP GO:0050900 leukocyte migration 0.009827526821978 511 122 11 0.0901639344262295 0.0215264187866928
GO:BP GO:0046632 alpha-beta T cell differentiation 0.00988834904198219 113 64 4 0.0625 0.0353982300884956
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.0101908877922792 194 38 4 0.105263157894737 0.0206185567010309
GO:BP GO:0045333 cellular respiration 0.0102351493795525 192 17 3 0.176470588235294 0.015625
GO:BP GO:0030101 natural killer cell activation 0.0102910975247513 84 38 3 0.0789473684210526 0.0357142857142857
GO:BP GO:0098771 inorganic ion homeostasis 0.01031172879141 761 97 12 0.123711340206186 0.0157687253613666
GO:BP GO:0050672 negative regulation of lymphocyte proliferation 0.01031172879141 85 38 3 0.0789473684210526 0.0352941176470588
GO:BP GO:0006955 immune response 0.01031172879141 2311 39 13 0.333333333333333 0.0056252704456945
GO:BP GO:0097305 response to alcohol 0.01031172879141 255 51 5 0.0980392156862745 0.0196078431372549
GO:BP GO:0009966 regulation of signal transduction 0.01031172879141 3165 131 38 0.290076335877863 0.0120063191153239
GO:BP GO:0032945 negative regulation of mononuclear cell proliferation 0.0105261744606064 86 38 3 0.0789473684210526 0.0348837209302326
GO:BP GO:0002367 cytokine production involved in immune response 0.0105965643145431 94 35 3 0.0857142857142857 0.0319148936170213
GO:BP GO:1902622 regulation of neutrophil migration 0.0108340401020313 43 77 3 0.038961038961039 0.0697674418604651
GO:BP GO:0042493 response to drug 0.0109325575701558 396 20 4 0.2 0.0101010101010101
GO:BP GO:1901700 response to oxygen-containing compound 0.0109325575701558 1739 51 13 0.254901960784314 0.00747556066705003
GO:BP GO:0002449 lymphocyte mediated immunity 0.0109325575701558 354 38 5 0.131578947368421 0.0141242937853107
GO:BP GO:0048522 positive regulation of cellular process 0.0109325575701558 5757 79 39 0.493670886075949 0.00677436164669099
GO:BP GO:0060429 epithelium development 0.010952094427839 1325 7 4 0.571428571428571 0.0030188679245283
GO:BP GO:0001818 negative regulation of cytokine production 0.011221879467008 381 36 5 0.138888888888889 0.0131233595800525
GO:BP GO:0032502 developmental process 0.011221879467008 6628 7 7 1 0.00105612552806276
GO:BP GO:0002703 regulation of leukocyte mediated immunity 0.011221879467008 205 38 4 0.105263157894737 0.0195121951219512
GO:BP GO:0050776 regulation of immune response 0.0113707443525668 996 38 8 0.210526315789474 0.00803212851405622
GO:BP GO:0040012 regulation of locomotion 0.0113707443525668 1104 130 18 0.138461538461538 0.016304347826087
GO:BP GO:0031349 positive regulation of defense response 0.0113707443525668 362 38 5 0.131578947368421 0.0138121546961326
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.0113946061676691 549 118 11 0.0932203389830508 0.0200364298724954
GO:BP GO:0070664 negative regulation of leukocyte proliferation 0.0115544079502127 92 38 3 0.0789473684210526 0.0326086956521739
GO:BP GO:0030003 cellular cation homeostasis 0.0115544079502127 673 97 11 0.11340206185567 0.0163447251114413
GO:BP GO:0002699 positive regulation of immune effector process 0.012305907781705 215 38 4 0.105263157894737 0.0186046511627907
GO:BP GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.0124144429959251 96 38 3 0.0789473684210526 0.03125
GO:BP GO:0030154 cell differentiation 0.0124144429959251 4350 7 6 0.857142857142857 0.00137931034482759
GO:BP GO:0000165 MAPK cascade 0.0125867296891064 935 118 15 0.127118644067797 0.0160427807486631
GO:BP GO:0006873 cellular ion homeostasis 0.0125867296891064 687 97 11 0.11340206185567 0.0160116448326055
GO:BP GO:0030334 regulation of cell migration 0.0125867296891064 999 122 16 0.131147540983607 0.016016016016016
GO:BP GO:0048523 negative regulation of cellular process 0.0125867296891064 5139 94 41 0.436170212765957 0.00797820587662969
GO:BP GO:0043065 positive regulation of apoptotic process 0.0125965372424203 604 110 11 0.1 0.0182119205298013
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.0127462403468354 107 35 3 0.0857142857142857 0.0280373831775701
GO:BP GO:0033077 T cell differentiation in thymus 0.0127462403468354 76 49 3 0.0612244897959184 0.0394736842105263
GO:BP GO:1901652 response to peptide 0.0127462403468354 551 16 4 0.25 0.00725952813067151
GO:BP GO:0048869 cellular developmental process 0.0128480757688718 4428 7 6 0.857142857142857 0.0013550135501355
GO:BP GO:0060548 negative regulation of cell death 0.0128701832901613 1038 38 8 0.210526315789474 0.00770712909441233
GO:BP GO:0006952 defense response 0.0128701832901613 1818 39 11 0.282051282051282 0.00605060506050605
GO:BP GO:0002702 positive regulation of production of molecular mediator of immune response 0.0129211557560378 100 38 3 0.0789473684210526 0.03
GO:BP GO:0006950 response to stress 0.013130997828346 4170 39 18 0.461538461538462 0.00431654676258993
GO:BP GO:0002821 positive regulation of adaptive immune response 0.0131565432818166 101 38 3 0.0789473684210526 0.0297029702970297
GO:BP GO:0001525 angiogenesis 0.0131746945232155 617 7 3 0.428571428571429 0.00486223662884927
GO:BP GO:0071622 regulation of granulocyte chemotaxis 0.013204868363516 50 77 3 0.038961038961039 0.06
GO:BP GO:0050801 ion homeostasis 0.013204868363516 808 97 12 0.123711340206186 0.0148514851485149
GO:BP GO:0043087 regulation of GTPase activity 0.0132381365302261 493 116 10 0.0862068965517241 0.0202839756592292
GO:BP GO:0043068 positive regulation of programmed cell death 0.0132381365302261 621 7 3 0.428571428571429 0.00483091787439614
GO:BP GO:0040007 growth 0.013375751317348 967 116 15 0.129310344827586 0.015511892450879
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0134043181912142 1842 130 25 0.192307692307692 0.0135722041259501
GO:BP GO:0051270 regulation of cellular component movement 0.0136257185437507 1141 130 18 0.138461538461538 0.0157756354075372
GO:BP GO:0002708 positive regulation of lymphocyte mediated immunity 0.0136858424919097 104 38 3 0.0789473684210526 0.0288461538461538
GO:BP GO:0014070 response to organic cyclic compound 0.0136858424919097 967 24 6 0.25 0.0062047569803516
GO:BP GO:0070228 regulation of lymphocyte apoptotic process 0.0137698630773956 55 72 3 0.0416666666666667 0.0545454545454545
GO:BP GO:1902106 negative regulation of leukocyte differentiation 0.01388049037179 105 38 3 0.0789473684210526 0.0285714285714286
GO:BP GO:0007165 signal transduction 0.0142652273310021 6309 54 30 0.555555555555556 0.00475511174512601
GO:BP GO:0045596 negative regulation of cell differentiation 0.0143594872466656 697 57 8 0.140350877192982 0.0114777618364419
GO:BP GO:1903707 negative regulation of hemopoiesis 0.0149721155128607 109 38 3 0.0789473684210526 0.0275229357798165
GO:BP GO:0030509 BMP signaling pathway 0.0149721155128607 158 57 4 0.0701754385964912 0.0253164556962025
GO:BP GO:0035025 positive regulation of Rho protein signal transduction 0.0149721155128607 32 130 3 0.0230769230769231 0.09375
GO:BP GO:0042981 regulation of apoptotic process 0.0149721155128607 1549 7 4 0.571428571428571 0.0025823111684958
GO:BP GO:0048518 positive regulation of biological process 0.0153980206506865 6363 79 41 0.518987341772152 0.00644350149300644
GO:BP GO:0043067 regulation of programmed cell death 0.0155995375851359 1582 7 4 0.571428571428571 0.00252844500632111
GO:BP GO:1902414 protein localization to cell junction 0.0155995375851359 113 81 4 0.0493827160493827 0.0353982300884956
GO:BP GO:0065009 regulation of molecular function 0.0157022216701658 3221 54 19 0.351851851851852 0.00589878919590189
GO:BP GO:0010942 positive regulation of cell death 0.0157022216701658 684 7 3 0.428571428571429 0.0043859649122807
GO:BP GO:0071773 cellular response to BMP stimulus 0.0162322504472506 171 92 5 0.0543478260869565 0.0292397660818713
GO:BP GO:0071772 response to BMP 0.0162322504472506 171 92 5 0.0543478260869565 0.0292397660818713
GO:BP GO:0009719 response to endogenous stimulus 0.016533563422055 1683 57 13 0.228070175438596 0.0077243018419489
GO:BP GO:0008219 cell death 0.0166124319111205 2292 38 12 0.315789473684211 0.00523560209424084
GO:BP GO:0048514 blood vessel morphogenesis 0.0166425565204481 711 7 3 0.428571428571429 0.00421940928270042
GO:BP GO:2000649 regulation of sodium ion transmembrane transporter activity 0.0168507221595927 53 84 3 0.0357142857142857 0.0566037735849057
GO:BP GO:0051239 regulation of multicellular organismal process 0.0169067686204519 2861 52 17 0.326923076923077 0.00594197832925551
GO:BP GO:0002443 leukocyte mediated immunity 0.0174165409425211 877 38 7 0.184210526315789 0.00798175598631699
GO:BP GO:0051056 regulation of small GTPase mediated signal transduction 0.0174165409425211 328 50 5 0.1 0.0152439024390244
GO:BP GO:0045445 myoblast differentiation 0.0174165409425211 84 116 4 0.0344827586206897 0.0476190476190476
GO:BP GO:0045597 positive regulation of cell differentiation 0.0174165409425211 879 38 7 0.184210526315789 0.00796359499431172
GO:BP GO:0070848 response to growth factor 0.0174165409425211 759 109 12 0.110091743119266 0.0158102766798419
GO:BP GO:0071621 granulocyte chemotaxis 0.0174165409425211 126 77 4 0.051948051948052 0.0317460317460317
GO:BP GO:0051693 actin filament capping 0.0174658228802318 44 105 3 0.0285714285714286 0.0681818181818182
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 0.0174851691749035 122 38 3 0.0789473684210526 0.0245901639344262
GO:BP GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 0.0180354078040756 102 97 4 0.0412371134020619 0.0392156862745098
GO:BP GO:0072678 T cell migration 0.0180716142351368 67 70 3 0.0428571428571429 0.0447761194029851
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 0.0185546689369009 289 17 3 0.176470588235294 0.0103806228373702
GO:BP GO:0051128 regulation of cellular component organization 0.0187313553803595 2412 116 27 0.232758620689655 0.0111940298507463
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0190547402689925 1160 38 8 0.210526315789474 0.00689655172413793
GO:BP GO:0001819 positive regulation of cytokine production 0.0190547402689925 452 38 5 0.131578947368421 0.0110619469026549
GO:BP GO:0080134 regulation of response to stress 0.0194470947608846 1443 38 9 0.236842105263158 0.00623700623700624
GO:BP GO:0061061 muscle structure development 0.0196574050139688 645 131 12 0.0916030534351145 0.0186046511627907
GO:BP GO:0001568 blood vessel development 0.0198963369946305 792 7 3 0.428571428571429 0.00378787878787879
GO:BP GO:0051592 response to calcium ion 0.019989831001029 151 33 3 0.0909090909090909 0.0198675496688742
GO:BP GO:0030835 negative regulation of actin filament depolymerization 0.020215205579663 48 105 3 0.0285714285714286 0.0625
GO:BP GO:0007265 Ras protein signal transduction 0.020215205579663 349 50 5 0.1 0.0143266475644699
GO:BP GO:0048513 animal organ development 0.0207737785273724 3672 17 9 0.529411764705882 0.00245098039215686
GO:BP GO:0007264 small GTPase mediated signal transduction 0.0207737785273724 515 50 6 0.12 0.0116504854368932
GO:BP GO:0043408 regulation of MAPK cascade 0.0207845254765669 730 118 12 0.101694915254237 0.0164383561643836
GO:BP GO:0046034 ATP metabolic process 0.020982162406352 314 17 3 0.176470588235294 0.00955414012738853
GO:BP GO:0001944 vasculature development 0.020982162406352 830 7 3 0.428571428571429 0.0036144578313253
GO:BP GO:0007266 Rho protein signal transduction 0.0212673372528441 136 130 5 0.0384615384615385 0.0367647058823529
GO:BP GO:0032501 multicellular organismal process 0.0213972299339438 7946 7 7 1 0.000880946388119809
GO:BP GO:1902305 regulation of sodium ion transmembrane transport 0.0213972299339438 63 84 3 0.0357142857142857 0.0476190476190476
GO:BP GO:0048519 negative regulation of biological process 0.0213972299339438 5757 94 43 0.457446808510638 0.00746916796942852
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 0.0213972299339438 88 60 3 0.05 0.0340909090909091
GO:BP GO:0002685 regulation of leukocyte migration 0.0213972299339438 211 122 6 0.0491803278688525 0.028436018957346
GO:BP GO:0030183 B cell differentiation 0.0213972299339438 140 38 3 0.0789473684210526 0.0214285714285714
GO:BP GO:0050921 positive regulation of chemotaxis 0.0213972299339438 141 77 4 0.051948051948052 0.0283687943262411
GO:BP GO:0046578 regulation of Ras protein signal transduction 0.0213972299339438 199 130 6 0.0461538461538462 0.0301507537688442
GO:BP GO:0070227 lymphocyte apoptotic process 0.0216138317532917 74 72 3 0.0416666666666667 0.0405405405405405
GO:BP GO:0031347 regulation of defense response 0.0217612764846551 704 38 6 0.157894736842105 0.00852272727272727
GO:BP GO:0051093 negative regulation of developmental process 0.0217678481369592 977 57 9 0.157894736842105 0.00921187308085977
GO:BP GO:0050729 positive regulation of inflammatory response 0.0217678481369592 142 38 3 0.0789473684210526 0.0211267605633803
GO:BP GO:0001701 in utero embryonic development 0.0217678481369592 365 50 5 0.1 0.0136986301369863
GO:BP GO:0045471 response to ethanol 0.0217678481369592 142 38 3 0.0789473684210526 0.0211267605633803
GO:BP GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport 0.0218436746983394 206 54 4 0.0740740740740741 0.0194174757281553
GO:BP GO:0035023 regulation of Rho protein signal transduction 0.0223457508673187 86 130 4 0.0307692307692308 0.0465116279069767
GO:BP GO:0030510 regulation of BMP signaling pathway 0.0224004595215368 96 57 3 0.0526315789473684 0.03125
GO:BP GO:2000146 negative regulation of cell motility 0.0227593512867018 369 122 8 0.0655737704918033 0.021680216802168
GO:BP GO:0007162 negative regulation of cell adhesion 0.0234560401021847 304 38 4 0.105263157894737 0.0131578947368421
GO:BP GO:0002700 regulation of production of molecular mediator of immune response 0.0234560401021847 148 38 3 0.0789473684210526 0.0202702702702703
GO:BP GO:0010243 response to organonitrogen compound 0.0237731275568118 1085 26 6 0.230769230769231 0.00552995391705069
GO:BP GO:0046580 negative regulation of Ras protein signal transduction 0.0238718840356945 50 113 3 0.0265486725663717 0.06
GO:BP GO:0042592 homeostatic process 0.0241276776990561 1981 7 4 0.571428571428571 0.00201918223119637
GO:BP GO:0006915 apoptotic process 0.0241536468403829 1990 7 4 0.571428571428571 0.00201005025125628
GO:BP GO:0098542 defense response to other organism 0.0241536468403829 1218 39 8 0.205128205128205 0.00656814449917898
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0241536468403829 982 38 7 0.184210526315789 0.00712830957230143
GO:BP GO:0050778 positive regulation of immune response 0.0242729180715826 753 49 7 0.142857142857143 0.00929614873837981
GO:BP GO:0097530 granulocyte migration 0.0242729180715826 151 77 4 0.051948051948052 0.0264900662251656
GO:BP GO:0051271 negative regulation of cellular component movement 0.0246360962802914 377 122 8 0.0655737704918033 0.0212201591511936
GO:BP GO:0046718 viral entry into host cell 0.0246360962802914 141 83 4 0.0481927710843374 0.0283687943262411
GO:BP GO:0009896 positive regulation of catabolic process 0.024777994450387 464 26 4 0.153846153846154 0.00862068965517241
GO:BP GO:1903670 regulation of sprouting angiogenesis 0.024777994450387 70 83 3 0.036144578313253 0.0428571428571429
GO:BP GO:0035239 tube morphogenesis 0.0257614331677053 950 7 3 0.428571428571429 0.00315789473684211
GO:BP GO:0071495 cellular response to endogenous stimulus 0.0257614331677053 1422 57 11 0.192982456140351 0.00773558368495077
GO:BP GO:0030834 regulation of actin filament depolymerization 0.0261035138716418 57 105 3 0.0285714285714286 0.0526315789473684
GO:BP GO:0001558 regulation of cell growth 0.0262746961566156 426 110 8 0.0727272727272727 0.0187793427230047
GO:BP GO:0042063 gliogenesis 0.0263353345471911 308 20 3 0.15 0.00974025974025974
GO:BP GO:0035556 intracellular signal transduction 0.0267003904220041 2772 53 16 0.30188679245283 0.00577200577200577
GO:BP GO:0009888 tissue development 0.0276009302901278 2107 7 4 0.571428571428571 0.0018984337921215
GO:BP GO:0051261 protein depolymerization 0.0276166393005974 117 105 4 0.0380952380952381 0.0341880341880342
GO:BP GO:0045087 innate immune response 0.028332284349054 998 39 7 0.179487179487179 0.00701402805611222
GO:BP GO:0012501 programmed cell death 0.0287787273886898 2143 7 4 0.571428571428571 0.00186654223051797
GO:BP GO:0055082 cellular chemical homeostasis 0.0295576893076025 841 97 11 0.11340206185567 0.0130796670630202
GO:BP GO:0022008 neurogenesis 0.0300045942590398 1675 79 15 0.189873417721519 0.00895522388059702
GO:BP GO:0051058 negative regulation of small GTPase mediated signal transduction 0.0300328876507101 57 113 3 0.0265486725663717 0.0526315789473684
GO:BP GO:1901698 response to nitrogen compound 0.0300866231059225 1172 26 6 0.230769230769231 0.00511945392491468
GO:BP GO:0044409 entry into host 0.0303249896027882 154 83 4 0.0481927710843374 0.025974025974026
GO:BP GO:0000902 cell morphogenesis 0.0303431038806234 1037 7 3 0.428571428571429 0.00289296046287367
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0304147413825717 1042 7 3 0.428571428571429 0.00287907869481766
GO:BP GO:0030042 actin filament depolymerization 0.0304147413825717 62 105 3 0.0285714285714286 0.0483870967741935
GO:BP GO:0042552 myelination 0.0306087992698009 135 96 4 0.0416666666666667 0.0296296296296296
GO:BP GO:0040013 negative regulation of locomotion 0.0306087992698009 401 122 8 0.0655737704918033 0.0199501246882793
GO:BP GO:0007272 ensheathment of neurons 0.0316897495796109 137 96 4 0.0416666666666667 0.0291970802919708
GO:BP GO:0008366 axon ensheathment 0.0316897495796109 137 96 4 0.0416666666666667 0.0291970802919708
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 0.0323456962346874 119 57 3 0.0526315789473684 0.0252100840336134
GO:BP GO:0009725 response to hormone 0.0324333168311612 921 24 5 0.208333333333333 0.00542888165038002
GO:BP GO:0001666 response to hypoxia 0.0324333168311612 367 37 4 0.108108108108108 0.0108991825613079
GO:BP GO:0006935 chemotaxis 0.0324333168311612 653 77 8 0.103896103896104 0.0122511485451761
GO:BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 0.0328035431951496 148 91 4 0.043956043956044 0.027027027027027
GO:BP GO:0042330 taxis 0.0328279021623795 656 77 8 0.103896103896104 0.0121951219512195
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.0331402306775622 1227 51 9 0.176470588235294 0.00733496332518337
GO:BP GO:0043409 negative regulation of MAPK cascade 0.0334874206961514 190 37 3 0.0810810810810811 0.0157894736842105
GO:BP GO:0080090 regulation of primary metabolic process 0.0341175799518879 6053 7 6 0.857142857142857 0.000991244011234099
GO:BP GO:0050954 sensory perception of mechanical stimulus 0.034752643194045 174 41 3 0.0731707317073171 0.0172413793103448
GO:BP GO:0016477 cell migration 0.0348642335767444 1649 20 6 0.3 0.00363856882959369
GO:BP GO:0043434 response to peptide hormone 0.035026459442679 462 16 3 0.1875 0.00649350649350649
GO:BP GO:0030837 negative regulation of actin filament polymerization 0.0350277554835189 68 105 3 0.0285714285714286 0.0441176470588235
GO:BP GO:0050896 response to stimulus 0.0350942971126901 9407 55 38 0.690909090909091 0.00403954501966621
GO:BP GO:0035295 tube development 0.0350976002864862 1146 7 3 0.428571428571429 0.00261780104712042
GO:BP GO:0036293 response to decreased oxygen levels 0.0356194667801282 382 37 4 0.108108108108108 0.0104712041884817
GO:BP GO:0002028 regulation of sodium ion transport 0.0363471946597279 87 84 3 0.0357142857142857 0.0344827586206897
GO:BP GO:0050864 regulation of B cell activation 0.0364185642490041 194 38 3 0.0789473684210526 0.0154639175257732
GO:BP GO:0009612 response to mechanical stimulus 0.0365338402401513 218 34 3 0.0882352941176471 0.0137614678899083
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0367679469625631 290 26 3 0.115384615384615 0.0103448275862069
GO:BP GO:0072676 lymphocyte migration 0.0368405586767677 117 122 4 0.0327868852459016 0.0341880341880342
GO:BP GO:0050727 regulation of inflammatory response 0.0368405586767677 381 38 4 0.105263157894737 0.010498687664042
GO:BP GO:0002831 regulation of response to biotic stimulus 0.0368671215805312 415 35 4 0.114285714285714 0.00963855421686747
GO:BP GO:0072359 circulatory system development 0.0369465237237156 1194 7 3 0.428571428571429 0.00251256281407035
GO:BP GO:0045089 positive regulation of innate immune response 0.0371704040073644 216 35 3 0.0857142857142857 0.0138888888888889
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0372627530495837 1202 7 3 0.428571428571429 0.00249584026622296
GO:BP GO:0034248 regulation of cellular amide metabolic process 0.0372627530495837 535 60 6 0.1 0.011214953271028
GO:BP GO:0043085 positive regulation of catalytic activity 0.0374021825902651 1418 46 9 0.195652173913043 0.00634696755994358
GO:BP GO:0031323 regulation of cellular metabolic process 0.0374288979226502 6269 7 6 0.857142857142857 0.000957090445047057
GO:BP GO:0048589 developmental growth 0.0384658118125483 649 116 10 0.0862068965517241 0.0154083204930663
GO:BP GO:0052126 movement in host environment 0.0386863611841616 177 83 4 0.0481927710843374 0.0225988700564972
GO:BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0389764799814068 136 57 3 0.0526315789473684 0.0220588235294118
GO:BP GO:0070482 response to oxygen levels 0.0398554999230258 408 37 4 0.108108108108108 0.00980392156862745
GO:BP GO:1901880 negative regulation of protein depolymerization 0.0401672077220898 75 105 3 0.0285714285714286 0.04
GO:BP GO:0030593 neutrophil chemotaxis 0.04069159317935 103 77 3 0.038961038961039 0.029126213592233
GO:BP GO:0045786 negative regulation of cell cycle 0.04069159317935 647 37 5 0.135135135135135 0.00772797527047913
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0408444109256054 2255 41 11 0.268292682926829 0.0048780487804878
GO:BP GO:0031326 regulation of cellular biosynthetic process 0.0413395322406204 4273 7 5 0.714285714285714 0.001170138076293
GO:BP GO:0030336 negative regulation of cell migration 0.041568010209415 353 122 7 0.0573770491803279 0.0198300283286119
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.041568010209415 3483 70 22 0.314285714285714 0.00631639391329314
GO:BP GO:0009628 response to abiotic stimulus 0.0428936447719064 1261 20 5 0.25 0.00396510705789056
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 0.0431846217371851 147 105 4 0.0380952380952381 0.0272108843537415
GO:BP GO:0016049 cell growth 0.0432612495511788 495 110 8 0.0727272727272727 0.0161616161616162
GO:BP GO:0048662 negative regulation of smooth muscle cell proliferation 0.0436005886239571 70 118 3 0.0254237288135593 0.0428571428571429
GO:BP GO:0009889 regulation of biosynthetic process 0.0439259648612804 4361 7 5 0.714285714285714 0.00114652602614079
GO:BP GO:0009967 positive regulation of signal transduction 0.0448359380231658 1598 6 3 0.5 0.00187734668335419
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0449695665034123 6603 7 6 0.857142857142857 0.000908677873693776
GO:BP GO:0016064 immunoglobulin mediated immune response 0.0450436171983139 223 38 3 0.0789473684210526 0.0134529147982063
GO:BP GO:0044093 positive regulation of molecular function 0.0450582810148135 1771 39 9 0.230769230769231 0.00508187464709204
GO:BP GO:0071216 cellular response to biotic stimulus 0.0455873959084771 238 36 3 0.0833333333333333 0.0126050420168067
GO:BP GO:0043066 negative regulation of apoptotic process 0.0455873959084771 921 38 6 0.157894736842105 0.00651465798045603
GO:BP GO:0048870 cell motility 0.0455873959084771 1828 20 6 0.3 0.00328227571115974
GO:BP GO:0050709 negative regulation of protein secretion 0.0455873959084771 78 109 3 0.0275229357798165 0.0384615384615385
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0455873959084771 783 116 11 0.0948275862068965 0.0140485312899106
GO:BP GO:0051674 localization of cell 0.0455873959084771 1828 20 6 0.3 0.00328227571115974
GO:BP GO:0019724 B cell mediated immunity 0.0455873959084771 226 38 3 0.0789473684210526 0.0132743362831858
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.0456240311092835 1628 6 3 0.5 0.00184275184275184
GO:BP GO:0052548 regulation of endopeptidase activity 0.0456240311092835 437 37 4 0.108108108108108 0.0091533180778032
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.045981011297465 1639 6 3 0.5 0.00183038438071995
GO:BP GO:0032272 negative regulation of protein polymerization 0.0460535910967014 82 105 3 0.0285714285714286 0.0365853658536585
GO:BP GO:0002833 positive regulation of response to biotic stimulus 0.0460936322257335 250 35 3 0.0857142857142857 0.012
GO:BP GO:0040008 regulation of growth 0.0460936322257335 681 116 10 0.0862068965517241 0.0146842878120411
GO:BP GO:0071363 cellular response to growth factor stimulus 0.0470309965831144 731 109 10 0.0917431192660551 0.0136798905608755
GO:BP GO:0065008 regulation of biological quality 0.0470309965831144 4131 54 20 0.37037037037037 0.00484144274993948
GO:BP GO:0043069 negative regulation of programmed cell death 0.047805704394761 943 38 6 0.157894736842105 0.0063626723223754
GO:BP GO:0006091 generation of precursor metabolites and energy 0.0478217490101081 538 17 3 0.176470588235294 0.00557620817843866
GO:BP GO:0009893 positive regulation of metabolic process 0.0478793233892642 3783 70 23 0.328571428571429 0.00607983082209886
GO:BP GO:0009653 anatomical structure morphogenesis 0.0489187536339916 2797 7 4 0.571428571428571 0.00143010368251698
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.0489187536339916 1707 6 3 0.5 0.00175746924428822
GO:BP GO:1903531 negative regulation of secretion by cell 0.0489187536339916 152 109 4 0.036697247706422 0.0263157894736842
GO:BP GO:0043242 negative regulation of protein-containing complex disassembly 0.0495232447477057 86 105 3 0.0285714285714286 0.0348837209302326
GO:BP GO:0048878 chemical homeostasis 0.0497259933106731 1229 97 13 0.134020618556701 0.0105777054515867
GO:BP GO:0097529 myeloid leukocyte migration 0.0498854524986696 221 116 5 0.0431034482758621 0.0226244343891403
GO:CC GO:0012506 vesicle membrane 0.00210111126429415 800 63 12 0.19047619047619 0.015
GO:CC GO:0005769 early endosome 0.00244401228808068 378 48 7 0.145833333333333 0.0185185185185185
GO:CC GO:0098803 respiratory chain complex 0.00244401228808068 86 17 3 0.176470588235294 0.0348837209302326
GO:CC GO:0032585 multivesicular body membrane 0.00244401228808068 14 107 3 0.0280373831775701 0.214285714285714
GO:CC GO:0009986 cell surface 0.00244401228808068 899 35 9 0.257142857142857 0.0100111234705228
GO:CC GO:0055038 recycling endosome membrane 0.00244401228808068 84 48 4 0.0833333333333333 0.0476190476190476
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.00244401228808068 779 63 11 0.174603174603175 0.0141206675224647
GO:CC GO:0005746 mitochondrial respirasome 0.00244401228808068 89 17 3 0.176470588235294 0.0337078651685393
GO:CC GO:0031901 early endosome membrane 0.00244401228808068 159 48 5 0.104166666666667 0.0314465408805031
GO:CC GO:0009897 external side of plasma membrane 0.00244401228808068 408 21 5 0.238095238095238 0.0122549019607843
GO:CC GO:0031224 intrinsic component of membrane 0.00250411191486408 5868 119 57 0.478991596638655 0.00971370143149284
GO:CC GO:0005768 endosome 0.00256426533217155 987 22 7 0.318181818181818 0.00709219858156028
GO:CC GO:0070469 respirasome 0.0026045173132681 103 17 3 0.176470588235294 0.029126213592233
GO:CC GO:1990204 oxidoreductase complex 0.00298803579007212 113 17 3 0.176470588235294 0.0265486725663717
GO:CC GO:0031410 cytoplasmic vesicle 0.00298803579007212 2424 91 25 0.274725274725275 0.0103135313531353
GO:CC GO:0097708 intracellular vesicle 0.00298803579007212 2428 91 25 0.274725274725275 0.0102965403624382
GO:CC GO:0016021 integral component of membrane 0.00309258731568834 5711 119 55 0.46218487394958 0.00963053755909648
GO:CC GO:0031301 integral component of organelle membrane 0.00339343286600397 382 42 6 0.142857142857143 0.0157068062827225
GO:CC GO:0016328 lateral plasma membrane 0.00339343286600397 68 78 4 0.0512820512820513 0.0588235294117647
GO:CC GO:0012505 endomembrane system 0.00346438033947222 4640 55 26 0.472727272727273 0.00560344827586207
GO:CC GO:0030054 cell junction 0.00426809908833846 2105 120 27 0.225 0.0128266033254157
GO:CC GO:0031300 intrinsic component of organelle membrane 0.00438379954254137 413 42 6 0.142857142857143 0.0145278450363196
GO:CC GO:0098800 inner mitochondrial membrane protein complex 0.00438379954254137 146 17 3 0.176470588235294 0.0205479452054795
GO:CC GO:0005911 cell-cell junction 0.00442646899895951 494 120 11 0.0916666666666667 0.0222672064777328
GO:CC GO:0005783 endoplasmic reticulum 0.00442646899895951 1982 54 15 0.277777777777778 0.00756811301715439
GO:CC GO:0098552 side of membrane 0.00614956231767876 619 21 5 0.238095238095238 0.00807754442649435
GO:CC GO:0000323 lytic vacuole 0.00614956231767876 712 75 10 0.133333333333333 0.0140449438202247
GO:CC GO:0031975 envelope 0.00614956231767876 1237 17 6 0.352941176470588 0.00485044462409054
GO:CC GO:0005764 lysosome 0.00614956231767876 712 75 10 0.133333333333333 0.0140449438202247
GO:CC GO:0031967 organelle envelope 0.00614956231767876 1237 17 6 0.352941176470588 0.00485044462409054
GO:CC GO:0005740 mitochondrial envelope 0.00621326550199585 797 17 5 0.294117647058824 0.00627352572145546
GO:CC GO:0031970 organelle envelope lumen 0.00663131314944237 97 32 3 0.09375 0.0309278350515464
GO:CC GO:0070161 anchoring junction 0.0068369153768817 836 130 15 0.115384615384615 0.0179425837320574
GO:CC GO:0000139 Golgi membrane 0.00684079964962544 771 48 8 0.166666666666667 0.0103761348897536
GO:CC GO:0030658 transport vesicle membrane 0.00684079964962544 209 63 5 0.0793650793650794 0.0239234449760766
GO:CC GO:0005886 plasma membrane 0.0076610736364613 5681 115 51 0.443478260869565 0.00897729273015314
GO:CC GO:0031090 organelle membrane 0.00917381201810569 3612 19 10 0.526315789473684 0.00276854928017719
GO:CC GO:0055037 recycling endosome 0.0107523079399413 188 48 4 0.0833333333333333 0.0212765957446809
GO:CC GO:0005773 vacuole 0.0107523079399413 810 75 10 0.133333333333333 0.0123456790123457
GO:CC GO:0010008 endosome membrane 0.0113928134424624 505 19 4 0.210526315789474 0.00792079207920792
GO:CC GO:0098588 bounding membrane of organelle 0.0117405256878055 2158 63 16 0.253968253968254 0.00741427247451344
GO:CC GO:0071944 cell periphery 0.0117405256878055 6169 125 57 0.456 0.00923974712271033
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0117405256878055 885 48 8 0.166666666666667 0.00903954802259887
GO:CC GO:0031256 leading edge membrane 0.0117405256878055 175 91 5 0.0549450549450549 0.0285714285714286
GO:CC GO:0098798 mitochondrial protein-containing complex 0.0121784047845357 270 17 3 0.176470588235294 0.0111111111111111
GO:CC GO:0005794 Golgi apparatus 0.0121877005407604 1623 54 12 0.222222222222222 0.00739371534195933
GO:CC GO:0043202 lysosomal lumen 0.0132331873240287 97 48 3 0.0625 0.0309278350515464
GO:CC GO:0030133 transport vesicle 0.014256103221579 414 42 5 0.119047619047619 0.0120772946859903
GO:CC GO:0005811 lipid droplet 0.0146547537817541 95 52 3 0.0576923076923077 0.0315789473684211
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0151448278208618 1726 119 21 0.176470588235294 0.0121668597914253
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.0192234537753865 158 35 3 0.0857142857142857 0.0189873417721519
GO:CC GO:0098590 plasma membrane region 0.0197959557618264 1240 125 17 0.136 0.0137096774193548
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.021071456458128 166 35 3 0.0857142857142857 0.0180722891566265
GO:CC GO:0031966 mitochondrial membrane 0.0218599417583983 746 17 4 0.235294117647059 0.00536193029490617
GO:CC GO:0030662 coated vesicle membrane 0.0234709665109002 177 35 3 0.0857142857142857 0.0169491525423729
GO:CC GO:0042383 sarcolemma 0.0254523954771748 140 91 4 0.043956043956044 0.0285714285714286
GO:CC GO:0005737 cytoplasm 0.02569672961959 11911 55 44 0.8 0.0036940643103014
GO:CC GO:0098857 membrane microdomain 0.0265199185092022 335 119 7 0.0588235294117647 0.0208955223880597
GO:CC GO:0005771 multivesicular body 0.0265199185092022 62 107 3 0.0280373831775701 0.0483870967741935
GO:CC GO:0045121 membrane raft 0.0265199185092022 335 119 7 0.0588235294117647 0.0208955223880597
GO:CC GO:0005887 integral component of plasma membrane 0.0286601037071272 1645 109 18 0.165137614678899 0.0109422492401216
GO:CC GO:0070062 extracellular exosome 0.0312122188103783 2176 42 11 0.261904761904762 0.00505514705882353
GO:CC GO:1903561 extracellular vesicle 0.0382828401486098 2261 42 11 0.261904761904762 0.00486510393631137
GO:CC GO:0043230 extracellular organelle 0.0382828401486098 2263 42 11 0.261904761904762 0.00486080424215643
GO:CC GO:0005925 focal adhesion 0.0382828401486098 420 130 8 0.0615384615384615 0.019047619047619
GO:CC GO:0099056 integral component of presynaptic membrane 0.0384994591718063 68 119 3 0.0252100840336134 0.0441176470588235
GO:CC GO:0030055 cell-substrate junction 0.038890408524206 427 130 8 0.0615384615384615 0.0187353629976581
GO:CC GO:0005775 vacuolar lumen 0.0390382056637117 174 48 3 0.0625 0.0172413793103448
GO:CC GO:0070160 tight junction 0.0390382056637117 131 120 4 0.0333333333333333 0.0305343511450382
GO:CC GO:0031982 vesicle 0.0390382056637117 4055 93 30 0.32258064516129 0.00739827373612824
GO:CC GO:0005743 mitochondrial inner membrane 0.0390382056637117 503 17 3 0.176470588235294 0.00596421471172962
GO:CC GO:0045202 synapse 0.0397048957882611 1349 119 16 0.134453781512605 0.0118606375092661
GO:CC GO:0097060 synaptic membrane 0.0413084440455686 384 119 7 0.0588235294117647 0.0182291666666667
GO:CC GO:0070820 tertiary granule 0.0446916987846245 163 55 3 0.0545454545454545 0.0184049079754601
GO:CC GO:0098889 intrinsic component of presynaptic membrane 0.046763935809346 77 119 3 0.0252100840336134 0.038961038961039
GO:CC GO:0019866 organelle inner membrane 0.0476608824892051 564 17 3 0.176470588235294 0.00531914893617021
GO:CC GO:0005739 mitochondrion 0.0478078725769776 1673 17 5 0.294117647058824 0.00298864315600717
GO:CC GO:0031984 organelle subcompartment 0.0492054526041922 1773 49 10 0.204081632653061 0.00564015792442188
GO:MF GO:0045125 bioactive lipid receptor activity 0.0161335819058452 15 89 3 0.0337078651685393 0.2
GO:MF GO:0140272 exogenous protein binding 0.0217151489662202 77 83 4 0.0481927710843374 0.051948051948052
GO:MF GO:0001618 virus receptor activity 0.0217151489662202 76 83 4 0.0481927710843374 0.0526315789473684
GO:MF GO:0009055 electron transfer activity 0.0217151489662202 148 17 3 0.176470588235294 0.0202702702702703
GO:MF GO:0042277 peptide binding 0.0474190675567045 314 35 4 0.114285714285714 0.0127388535031847
HP HP:0001112 Leber optic atrophy 0.00380380735593002 10 17 3 0.176470588235294 0.3
HP HP:0000576 Centrocecal scotoma 0.00380380735593002 12 17 3 0.176470588235294 0.25
HP HP:0007768 Central retinal vessel vascular tortuosity 0.00380380735593002 11 17 3 0.176470588235294 0.272727272727273
HP HP:0000631 Retinal arterial tortuosity 0.00380380735593002 11 17 3 0.176470588235294 0.272727272727273
HP HP:0000603 Central scotoma 0.00597140096172217 45 17 4 0.235294117647059 0.0888888888888889
HP HP:0200125 Mitochondrial respiratory chain defects 0.00794950745381154 18 17 3 0.176470588235294 0.166666666666667
HP HP:0001427 Mitochondrial inheritance 0.00794950745381154 18 17 3 0.176470588235294 0.166666666666667
HP HP:0007763 Retinal telangiectasia 0.00824069551149591 19 17 3 0.176470588235294 0.157894736842105
HP HP:0005116 Arterial tortuosity 0.00859754336117968 20 17 3 0.176470588235294 0.15
HP HP:0004948 Vascular tortuosity 0.0104039104595142 22 17 3 0.176470588235294 0.136363636363636
HP HP:0004309 Ventricular preexcitation 0.0108513471626239 23 17 3 0.176470588235294 0.130434782608696
HP HP:0000575 Scotoma 0.0179576269921601 74 17 4 0.235294117647059 0.0540540540540541
HP HP:0000622 Blurred vision 0.0218214912704268 32 17 3 0.176470588235294 0.09375
HP HP:0002572 Episodic vomiting 0.0218214912704268 32 17 3 0.176470588235294 0.09375
HP HP:0007924 Slow decrease in visual acuity 0.0218214912704268 32 17 3 0.176470588235294 0.09375
HP HP:0003200 Ragged-red muscle fibers 0.0399930186745603 40 17 3 0.176470588235294 0.075
HP HP:0012841 Retinal vascular tortuosity 0.0405169815388398 41 17 3 0.176470588235294 0.0731707317073171

pTNI05 transcription factor target enrichment of top program genes

TF enrichment of pTNI05
TFs corrosponding to activation of pTNI05. (Left) pearson correlation of TF expression and gene expression program activatity in T/NK/ILC cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.