pM16 program activity among Myeloid cells

Activation of pM16
pM16 gene program activation in Myeloid cells.
Gene program activation of pM16 by different cell subtypes
pM16 gene program activation among cells of different subtypes (Myeloid cells).

pM16 top program genes

Top genes of pM16 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pM16 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pM16
pM16 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002274 myeloid leukocyte activation 1.45739815305327e-25 667 42 27 0.642857142857143 0.04047976011994
GO:BP GO:0002283 neutrophil activation involved in immune response 1.70871983521273e-24 485 42 24 0.571428571428571 0.0494845360824742
GO:BP GO:0043312 neutrophil degranulation 1.70871983521273e-24 482 42 24 0.571428571428571 0.0497925311203319
GO:BP GO:0042119 neutrophil activation 1.93937448908799e-24 498 42 24 0.571428571428571 0.0481927710843374
GO:BP GO:0002446 neutrophil mediated immunity 1.93937448908799e-24 497 42 24 0.571428571428571 0.0482897384305835
GO:BP GO:0036230 granulocyte activation 2.1563276931803e-24 504 42 24 0.571428571428571 0.0476190476190476
GO:BP GO:0043299 leukocyte degranulation 7.76132445577193e-24 535 42 24 0.571428571428571 0.0448598130841121
GO:BP GO:0002275 myeloid cell activation involved in immune response 1.15636576109148e-23 547 42 24 0.571428571428571 0.0438756855575868
GO:BP GO:0002444 myeloid leukocyte mediated immunity 1.22409997045031e-23 551 42 24 0.571428571428571 0.043557168784029
GO:BP GO:0045055 regulated exocytosis 4.49705634515784e-23 785 42 26 0.619047619047619 0.0331210191082803
GO:BP GO:0006887 exocytosis 1.52570206922262e-21 904 42 26 0.619047619047619 0.0287610619469027
GO:BP GO:0002366 leukocyte activation involved in immune response 4.87805273794765e-21 717 42 24 0.571428571428571 0.0334728033472803
GO:BP GO:0002263 cell activation involved in immune response 5.13685904912418e-21 721 42 24 0.571428571428571 0.0332871012482663
GO:BP GO:0002443 leukocyte mediated immunity 4.81725559923497e-19 877 42 24 0.571428571428571 0.0273660205245154
GO:BP GO:0045321 leukocyte activation 9.34788011432468e-19 1332 42 27 0.642857142857143 0.0202702702702703
GO:BP GO:0001775 cell activation 1.76999717522473e-17 1495 42 27 0.642857142857143 0.0180602006688963
GO:BP GO:0032940 secretion by cell 3.25137564562554e-17 1364 42 26 0.619047619047619 0.0190615835777126
GO:BP GO:0140352 export from cell 8.09344087321069e-17 1418 42 26 0.619047619047619 0.0183356840620592
GO:BP GO:0046903 secretion 3.15755777314333e-16 1501 42 26 0.619047619047619 0.0173217854763491
GO:BP GO:0016192 vesicle-mediated transport 1.02729808713489e-15 2180 42 29 0.69047619047619 0.013302752293578
GO:BP GO:0002252 immune effector process 3.44623154915246e-15 1309 42 24 0.571428571428571 0.0183346065699007
GO:BP GO:0006955 immune response 8.68994749997211e-13 2311 42 27 0.642857142857143 0.0116832540025963
GO:BP GO:0002376 immune system process 5.36221593553426e-11 3278 42 29 0.69047619047619 0.00884685784014643
GO:BP GO:0051649 establishment of localization in cell 1.04017709718653e-10 2813 42 27 0.642857142857143 0.00959829363668681
GO:BP GO:0051641 cellular localization 3.2521710388592e-09 3541 42 28 0.666666666666667 0.00790737079920926
GO:BP GO:0098542 defense response to other organism 6.28206520738893e-09 1218 29 15 0.517241379310345 0.0123152709359606
GO:BP GO:0006952 defense response 1.26545559374843e-08 1818 29 17 0.586206896551724 0.00935093509350935
GO:BP GO:0032103 positive regulation of response to external stimulus 1.93083509138212e-08 513 23 10 0.434782608695652 0.0194931773879142
GO:BP GO:0072593 reactive oxygen species metabolic process 6.61492713167052e-08 290 42 10 0.238095238095238 0.0344827586206897
GO:BP GO:0045087 innate immune response 7.71719132888161e-08 998 24 12 0.5 0.0120240480961924
GO:BP GO:0031349 positive regulation of defense response 1.67927691394724e-07 362 20 8 0.4 0.0220994475138122
GO:BP GO:0043207 response to external biotic stimulus 2.13306277727776e-07 1594 29 15 0.517241379310345 0.00941028858218319
GO:BP GO:0051707 response to other organism 2.13306277727776e-07 1592 29 15 0.517241379310345 0.00942211055276382
GO:BP GO:0009607 response to biotic stimulus 2.72369764444778e-07 1626 29 15 0.517241379310345 0.00922509225092251
GO:BP GO:0032101 regulation of response to external stimulus 3.7183821930945e-07 1051 26 12 0.461538461538462 0.0114176974310181
GO:BP GO:0001816 cytokine production 5.00007687421514e-07 844 26 11 0.423076923076923 0.0130331753554502
GO:BP GO:0050832 defense response to fungus 5.68324156370031e-07 40 3 3 1 0.075
GO:BP GO:0006810 transport 7.36743337701183e-07 5224 42 30 0.714285714285714 0.0057427258805513
GO:BP GO:0002221 pattern recognition receptor signaling pathway 8.28958426372369e-07 213 26 7 0.269230769230769 0.0328638497652582
GO:BP GO:2000377 regulation of reactive oxygen species metabolic process 9.73463348135661e-07 203 42 8 0.19047619047619 0.0394088669950739
GO:BP GO:0009620 response to fungus 1.29090772661193e-06 54 3 3 1 0.0555555555555556
GO:BP GO:0051234 establishment of localization 1.35772674845849e-06 5372 42 30 0.714285714285714 0.00558451228592703
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 2.12637916374259e-06 2255 29 16 0.551724137931034 0.00709534368070953
GO:BP GO:0006954 inflammatory response 2.91778450060826e-06 794 39 12 0.307692307692308 0.0151133501259446
GO:BP GO:0009605 response to external stimulus 3.40443194975612e-06 2944 42 22 0.523809523809524 0.00747282608695652
GO:BP GO:0006959 humoral immune response 3.40443194975612e-06 384 12 6 0.5 0.015625
GO:BP GO:0048584 positive regulation of response to stimulus 3.90028246678116e-06 2344 26 15 0.576923076923077 0.00639931740614334
GO:BP GO:0002684 positive regulation of immune system process 4.14779213364054e-06 1065 26 11 0.423076923076923 0.0103286384976526
GO:BP GO:0051179 localization 4.36213679699341e-06 6901 42 33 0.785714285714286 0.00478191566439646
GO:BP GO:2000379 positive regulation of reactive oxygen species metabolic process 6.90632196751556e-06 107 42 6 0.142857142857143 0.0560747663551402
GO:BP GO:0030593 neutrophil chemotaxis 7.15873898705104e-06 103 3 3 1 0.029126213592233
GO:BP GO:0006801 superoxide metabolic process 1.06878874198669e-05 67 38 5 0.131578947368421 0.0746268656716418
GO:BP GO:1990266 neutrophil migration 1.21051483976717e-05 124 3 3 1 0.0241935483870968
GO:BP GO:0071621 granulocyte chemotaxis 1.24824232724997e-05 126 3 3 1 0.0238095238095238
GO:BP GO:0031347 regulation of defense response 1.55229957196703e-05 704 20 8 0.4 0.0113636363636364
GO:BP GO:0050729 positive regulation of inflammatory response 1.71586534877386e-05 142 3 3 1 0.0211267605633803
GO:BP GO:0019730 antimicrobial humoral response 1.78323350047908e-05 145 3 3 1 0.0206896551724138
GO:BP GO:0097530 granulocyte migration 1.95157588433598e-05 151 3 3 1 0.0198675496688742
GO:BP GO:0090322 regulation of superoxide metabolic process 1.95157588433598e-05 32 38 4 0.105263157894737 0.125
GO:BP GO:0071447 cellular response to hydroperoxide 2.02287583189099e-05 8 41 3 0.0731707317073171 0.375
GO:BP GO:0001906 cell killing 2.04788309153056e-05 175 18 5 0.277777777777778 0.0285714285714286
GO:BP GO:0051092 positive regulation of NF-kappaB transcription factor activity 2.26912065004871e-05 162 3 3 1 0.0185185185185185
GO:BP GO:0019882 antigen processing and presentation 2.49877937468559e-05 234 26 6 0.230769230769231 0.0256410256410256
GO:BP GO:0043277 apoptotic cell clearance 2.62610157948497e-05 52 26 4 0.153846153846154 0.0769230769230769
GO:BP GO:0002831 regulation of response to biotic stimulus 4.15710711387849e-05 415 26 7 0.269230769230769 0.0168674698795181
GO:BP GO:0002253 activation of immune response 4.50262738375287e-05 568 20 7 0.35 0.0123239436619718
GO:BP GO:0097529 myeloid leukocyte migration 5.1040743806627e-05 221 3 3 1 0.0135746606334842
GO:BP GO:0001819 positive regulation of cytokine production 5.1684425602754e-05 452 35 8 0.228571428571429 0.0176991150442478
GO:BP GO:0030595 leukocyte chemotaxis 5.39130286059457e-05 227 3 3 1 0.013215859030837
GO:BP GO:0002224 toll-like receptor signaling pathway 8.07686841658926e-05 161 26 5 0.192307692307692 0.031055900621118
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 8.86405350310709e-05 270 3 3 1 0.0111111111111111
GO:BP GO:0002682 regulation of immune system process 9.12105607253626e-05 1617 39 14 0.358974358974359 0.00865800865800866
GO:BP GO:0048583 regulation of response to stimulus 0.000103131765378803 4278 23 16 0.695652173913043 0.0037400654511454
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 0.000111118245161616 174 26 5 0.192307692307692 0.028735632183908
GO:BP GO:0060326 cell chemotaxis 0.000124980988738187 310 3 3 1 0.00967741935483871
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.00013211102435854 182 26 5 0.192307692307692 0.0274725274725275
GO:BP GO:0050776 regulation of immune response 0.000137455226036888 996 20 8 0.4 0.00803212851405622
GO:BP GO:0034599 cellular response to oxidative stress 0.000146209078278456 316 41 7 0.170731707317073 0.0221518987341772
GO:BP GO:0009617 response to bacterium 0.000146209078278456 743 19 7 0.368421052631579 0.00942126514131898
GO:BP GO:0002833 positive regulation of response to biotic stimulus 0.000146536846981839 250 20 5 0.25 0.02
GO:BP GO:0042742 defense response to bacterium 0.000152183302884341 349 15 5 0.333333333333333 0.0143266475644699
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.000157162945116487 192 26 5 0.192307692307692 0.0260416666666667
GO:BP GO:0032760 positive regulation of tumor necrosis factor production 0.000159872459625055 88 26 4 0.153846153846154 0.0454545454545455
GO:BP GO:0007263 nitric oxide mediated signal transduction 0.000164118821263636 27 26 3 0.115384615384615 0.111111111111111
GO:BP GO:0032755 positive regulation of interleukin-6 production 0.000164118821263636 89 26 4 0.153846153846154 0.0449438202247191
GO:BP GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 0.000177221147594557 91 26 4 0.153846153846154 0.043956043956044
GO:BP GO:0006950 response to stress 0.000178772985094225 4170 42 23 0.547619047619048 0.00551558752997602
GO:BP GO:0050727 regulation of inflammatory response 0.000195983327961016 381 3 3 1 0.0078740157480315
GO:BP GO:0050778 positive regulation of immune response 0.000209690125466143 753 20 7 0.35 0.00929614873837981
GO:BP GO:0033194 response to hydroperoxide 0.000209690125466143 19 41 3 0.0731707317073171 0.157894736842105
GO:BP GO:1903428 positive regulation of reactive oxygen species biosynthetic process 0.000255542346616388 62 42 4 0.0952380952380952 0.0645161290322581
GO:BP GO:0042554 superoxide anion generation 0.000257015926332717 35 24 3 0.125 0.0857142857142857
GO:BP GO:1990776 response to angiotensin 0.000257015926332717 28 30 3 0.1 0.107142857142857
GO:BP GO:0045730 respiratory burst 0.000257015926332717 35 24 3 0.125 0.0857142857142857
GO:BP GO:1903409 reactive oxygen species biosynthetic process 0.000283312535893773 135 42 5 0.119047619047619 0.037037037037037
GO:BP GO:0006909 phagocytosis 0.000283312535893773 387 26 6 0.230769230769231 0.0155038759689922
GO:BP GO:1901700 response to oxygen-containing compound 0.000297977379259786 1739 41 14 0.341463414634146 0.00805060379528465
GO:BP GO:0051090 regulation of DNA-binding transcription factor activity 0.000298534700646319 456 3 3 1 0.00657894736842105
GO:BP GO:0062197 cellular response to chemical stress 0.000298534700646319 365 41 7 0.170731707317073 0.0191780821917808
GO:BP GO:0080134 regulation of response to stress 0.000301619636856731 1443 26 10 0.384615384615385 0.00693000693000693
GO:BP GO:0002218 activation of innate immune response 0.000310985938637414 144 20 4 0.2 0.0277777777777778
GO:BP GO:0050900 leukocyte migration 0.000406100397658486 511 3 3 1 0.00587084148727984
GO:BP GO:0033993 response to lipid 0.000520701106986097 918 26 8 0.307692307692308 0.00871459694989107
GO:BP GO:0002576 platelet degranulation 0.000525801963017644 126 26 4 0.153846153846154 0.0317460317460317
GO:BP GO:0007155 cell adhesion 0.00058198699320826 1492 38 12 0.315789473684211 0.00804289544235925
GO:BP GO:0022610 biological adhesion 0.000604698744088927 1499 38 12 0.315789473684211 0.00800533689126084
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.000620978952201646 497 15 5 0.333333333333333 0.0100603621730382
GO:BP GO:0002694 regulation of leukocyte activation 0.000652266328322695 610 39 8 0.205128205128205 0.0131147540983607
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.000725880372162553 516 15 5 0.333333333333333 0.00968992248062015
GO:BP GO:0006935 chemotaxis 0.000764961101919098 653 3 3 1 0.00459418070444104
GO:BP GO:0042063 gliogenesis 0.000766907584589385 308 5 3 0.6 0.00974025974025974
GO:BP GO:0042330 taxis 0.000766907584589385 656 3 3 1 0.00457317073170732
GO:BP GO:0050865 regulation of cell activation 0.000993105830608029 655 39 8 0.205128205128205 0.0122137404580153
GO:BP GO:0019932 second-messenger-mediated signaling 0.00100877920008678 327 39 6 0.153846153846154 0.018348623853211
GO:BP GO:0006979 response to oxidative stress 0.00114498571037557 466 41 7 0.170731707317073 0.0150214592274678
GO:BP GO:0048518 positive regulation of biological process 0.00119040798477069 6363 24 18 0.75 0.00282885431400283
GO:BP GO:0032680 regulation of tumor necrosis factor production 0.0012168287075959 163 26 4 0.153846153846154 0.0245398773006135
GO:BP GO:0045089 positive regulation of innate immune response 0.00122425411431801 216 20 4 0.2 0.0185185185185185
GO:BP GO:0006875 cellular metal ion homeostasis 0.00124127260513543 593 15 5 0.333333333333333 0.00843170320404722
GO:BP GO:0032640 tumor necrosis factor production 0.00124127260513543 165 26 4 0.153846153846154 0.0242424242424242
GO:BP GO:0010942 positive regulation of cell death 0.00125485060439827 684 39 8 0.205128205128205 0.0116959064327485
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.00126637476026874 167 26 4 0.153846153846154 0.0239520958083832
GO:BP GO:0042116 macrophage activation 0.0012717112623338 110 39 4 0.102564102564103 0.0363636363636364
GO:BP GO:0032675 regulation of interleukin-6 production 0.00127397142470798 168 26 4 0.153846153846154 0.0238095238095238
GO:BP GO:0050896 response to stimulus 0.00127397142470798 9407 42 34 0.80952380952381 0.00361432975443818
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.00132197354688223 170 26 4 0.153846153846154 0.0235294117647059
GO:BP GO:0032635 interleukin-6 production 0.00137436317403174 172 26 4 0.153846153846154 0.0232558139534884
GO:BP GO:0001817 regulation of cytokine production 0.0014420106546001 806 26 7 0.269230769230769 0.0086848635235732
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.00152445624049009 230 38 5 0.131578947368421 0.0217391304347826
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.00157780910257787 232 38 5 0.131578947368421 0.021551724137931
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00160055728827239 1455 26 9 0.346153846153846 0.00618556701030928
GO:BP GO:1903426 regulation of reactive oxygen species biosynthetic process 0.00164639514188025 111 42 4 0.0952380952380952 0.036036036036036
GO:BP GO:0007154 cell communication 0.00164639514188025 6829 40 27 0.675 0.00395372675355103
GO:BP GO:0023052 signaling 0.00165263677765368 6810 27 20 0.740740740740741 0.00293685756240822
GO:BP GO:0002757 immune response-activating signal transduction 0.00177102557111319 477 20 5 0.25 0.010482180293501
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.00177102557111319 477 20 5 0.25 0.010482180293501
GO:BP GO:0055065 metal ion homeostasis 0.00184193600984574 667 15 5 0.333333333333333 0.00749625187406297
GO:BP GO:0030003 cellular cation homeostasis 0.00188985169532785 673 15 5 0.333333333333333 0.00742942050520059
GO:BP GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 0.00201312107257462 75 26 3 0.115384615384615 0.04
GO:BP GO:0070663 regulation of leukocyte proliferation 0.00203905467474058 251 38 5 0.131578947368421 0.0199203187250996
GO:BP GO:0006873 cellular ion homeostasis 0.00203905467474058 687 15 5 0.333333333333333 0.00727802037845706
GO:BP GO:0007165 signal transduction 0.00211504928511862 6309 27 19 0.703703703703704 0.00301157077191314
GO:BP GO:0070887 cellular response to chemical stimulus 0.00219340047981805 3393 41 18 0.439024390243902 0.00530503978779841
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.00220157029168749 1037 3 3 1 0.00289296046287367
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.00225464840272661 512 20 5 0.25 0.009765625
GO:BP GO:0002764 immune response-regulating signaling pathway 0.00229446354311575 515 20 5 0.25 0.00970873786407767
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 0.00230813977690192 80 26 3 0.115384615384615 0.0375
GO:BP GO:0001774 microglial cell activation 0.00255276218023327 55 39 3 0.0769230769230769 0.0545454545454545
GO:BP GO:0002696 positive regulation of leukocyte activation 0.00259954499518723 412 39 6 0.153846153846154 0.0145631067961165
GO:BP GO:0071230 cellular response to amino acid stimulus 0.00260403922710467 68 32 3 0.09375 0.0441176470588235
GO:BP GO:0010647 positive regulation of cell communication 0.0026661788777965 1777 39 12 0.307692307692308 0.00675295441755768
GO:BP GO:0098609 cell-cell adhesion 0.00269553799812521 894 35 8 0.228571428571429 0.00894854586129754
GO:BP GO:0023056 positive regulation of signaling 0.00270971443499635 1782 39 12 0.307692307692308 0.00673400673400673
GO:BP GO:0055080 cation homeostasis 0.00278656568486682 750 15 5 0.333333333333333 0.00666666666666667
GO:BP GO:0002220 innate immune response activating cell surface receptor signaling pathway 0.00284305032745885 115 20 3 0.15 0.0260869565217391
GO:BP GO:0002758 innate immune response-activating signal transduction 0.00285929027394943 116 20 3 0.15 0.0258620689655172
GO:BP GO:0050867 positive regulation of cell activation 0.00285929027394943 424 39 6 0.153846153846154 0.0141509433962264
GO:BP GO:0044093 positive regulation of molecular function 0.00285929027394943 1771 15 7 0.466666666666667 0.00395256916996047
GO:BP GO:0098771 inorganic ion homeostasis 0.00288022765800462 761 15 5 0.333333333333333 0.00657030223390276
GO:BP GO:0048661 positive regulation of smooth muscle cell proliferation 0.00305931458126563 103 23 3 0.130434782608696 0.029126213592233
GO:BP GO:0030888 regulation of B cell proliferation 0.00324317628042817 63 38 3 0.0789473684210526 0.0476190476190476
GO:BP GO:0016477 cell migration 0.00327915282284488 1649 5 4 0.8 0.00242571255306246
GO:BP GO:0043068 positive regulation of programmed cell death 0.00327915282284488 621 39 7 0.179487179487179 0.0112721417069243
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.00327915282284488 1227 41 10 0.24390243902439 0.00814995925020375
GO:BP GO:0071229 cellular response to acid chemical 0.00330931169954322 76 32 3 0.09375 0.0394736842105263
GO:BP GO:0045088 regulation of innate immune response 0.00330984594294997 309 20 4 0.2 0.0129449838187702
GO:BP GO:0046651 lymphocyte proliferation 0.00330984594294997 294 21 4 0.19047619047619 0.0136054421768707
GO:BP GO:0097305 response to alcohol 0.00330984594294997 255 24 4 0.166666666666667 0.0156862745098039
GO:BP GO:0019935 cyclic-nucleotide-mediated signaling 0.00335203235232157 95 26 3 0.115384615384615 0.0315789473684211
GO:BP GO:0001558 regulation of cell growth 0.00335816938593209 426 15 4 0.266666666666667 0.00938967136150235
GO:BP GO:0032943 mononuclear cell proliferation 0.00339239232305409 297 21 4 0.19047619047619 0.0134680134680135
GO:BP GO:0019725 cellular homeostasis 0.00348887147399367 981 26 7 0.269230769230769 0.00713557594291539
GO:BP GO:0050801 ion homeostasis 0.00352867578368272 808 15 5 0.333333333333333 0.00618811881188119
GO:BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 0.0036482825119952 103 25 3 0.12 0.029126213592233
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 0.0036482825119952 99 26 3 0.115384615384615 0.0303030303030303
GO:BP GO:0009967 positive regulation of signal transduction 0.0038203151816499 1598 39 11 0.282051282051282 0.00688360450563204
GO:BP GO:0043500 muscle adaptation 0.00387558902476917 127 21 3 0.142857142857143 0.0236220472440945
GO:BP GO:0055082 cellular chemical homeostasis 0.00407128050936342 841 15 5 0.333333333333333 0.00594530321046373
GO:BP GO:0052548 regulation of endopeptidase activity 0.00421887753280624 437 7 3 0.428571428571429 0.0068649885583524
GO:BP GO:0048870 cell motility 0.00435515779592859 1828 5 4 0.8 0.00218818380743982
GO:BP GO:0032611 interleukin-1 beta production 0.00435515779592859 107 26 3 0.115384615384615 0.0280373831775701
GO:BP GO:0070661 leukocyte proliferation 0.00435515779592859 325 21 4 0.19047619047619 0.0123076923076923
GO:BP GO:0051674 localization of cell 0.00435515779592859 1828 5 4 0.8 0.00218818380743982
GO:BP GO:0043085 positive regulation of catalytic activity 0.00435515779592859 1418 3 3 1 0.00211565585331453
GO:BP GO:0071417 cellular response to organonitrogen compound 0.00439145087762043 666 39 7 0.179487179487179 0.0105105105105105
GO:BP GO:0050766 positive regulation of phagocytosis 0.00448026174057823 67 42 3 0.0714285714285714 0.0447761194029851
GO:BP GO:0006809 nitric oxide biosynthetic process 0.00467705866689947 82 35 3 0.0857142857142857 0.0365853658536585
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.00474278499758806 1477 3 3 1 0.002031144211239
GO:BP GO:0052547 regulation of peptidase activity 0.00479653244834529 467 7 3 0.428571428571429 0.00642398286937901
GO:BP GO:0043405 regulation of MAP kinase activity 0.00479653244834529 316 39 5 0.128205128205128 0.0158227848101266
GO:BP GO:0010243 response to organonitrogen compound 0.00508236747459788 1085 41 9 0.219512195121951 0.00829493087557604
GO:BP GO:0016049 cell growth 0.00508236747459788 495 15 4 0.266666666666667 0.00808080808080808
GO:BP GO:0046209 nitric oxide metabolic process 0.00536317094422388 87 35 3 0.0857142857142857 0.0344827586206897
GO:BP GO:0051247 positive regulation of protein metabolic process 0.00547664457979945 1564 3 3 1 0.00191815856777494
GO:BP GO:2001057 reactive nitrogen species metabolic process 0.00550163986947865 88 35 3 0.0857142857142857 0.0340909090909091
GO:BP GO:0010033 response to organic substance 0.00565592256779958 3412 41 17 0.414634146341463 0.00498241500586166
GO:BP GO:0040011 locomotion 0.00598582419631548 2028 5 4 0.8 0.0019723865877712
GO:BP GO:0032612 interleukin-1 production 0.00632910707858483 126 26 3 0.115384615384615 0.0238095238095238
GO:BP GO:0006911 phagocytosis, engulfment 0.00642663774543928 127 26 3 0.115384615384615 0.0236220472440945
GO:BP GO:1901699 cellular response to nitrogen compound 0.00655332099137503 724 39 7 0.179487179487179 0.00966850828729282
GO:BP GO:0043065 positive regulation of apoptotic process 0.0067418919877932 604 23 5 0.217391304347826 0.00827814569536424
GO:BP GO:0006956 complement activation 0.00674360107858784 180 19 3 0.157894736842105 0.0166666666666667
GO:BP GO:0045471 response to ethanol 0.00680937667957756 142 24 3 0.125 0.0211267605633803
GO:BP GO:0044248 cellular catabolic process 0.00685347693876561 2347 39 13 0.333333333333333 0.00553898593949723
GO:BP GO:0034765 regulation of ion transmembrane transport 0.00690764374142663 583 24 5 0.208333333333333 0.00857632933104631
GO:BP GO:0007417 central nervous system development 0.00691526752042006 1032 21 6 0.285714285714286 0.00581395348837209
GO:BP GO:0034762 regulation of transmembrane transport 0.00707417365268632 588 24 5 0.208333333333333 0.00850340136054422
GO:BP GO:0099024 plasma membrane invagination 0.0073596995282312 136 26 3 0.115384615384615 0.0220588235294118
GO:BP GO:0010628 positive regulation of gene expression 0.00749856598248926 1160 26 7 0.269230769230769 0.00603448275862069
GO:BP GO:1902531 regulation of intracellular signal transduction 0.0075989340610772 1842 13 6 0.461538461538462 0.00325732899022801
GO:BP GO:1901698 response to nitrogen compound 0.00775765788465124 1172 41 9 0.219512195121951 0.00767918088737201
GO:BP GO:0048545 response to steroid hormone 0.00800140088902712 349 24 4 0.166666666666667 0.0114613180515759
GO:BP GO:0043200 response to amino acid 0.00812686695871535 115 32 3 0.09375 0.0260869565217391
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.00830950338209287 325 26 4 0.153846153846154 0.0123076923076923
GO:BP GO:0010324 membrane invagination 0.00832300163245741 144 26 3 0.115384615384615 0.0208333333333333
GO:BP GO:0042100 B cell proliferation 0.00837170664314371 98 38 3 0.0789473684210526 0.0306122448979592
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00853384099655194 3210 27 12 0.444444444444444 0.00373831775700935
GO:BP GO:0006928 movement of cell or subcellular component 0.00868030267226475 2311 5 4 0.8 0.00173085244482908
GO:BP GO:0001932 regulation of protein phosphorylation 0.00916218311129923 1240 40 9 0.225 0.00725806451612903
GO:BP GO:0035556 intracellular signal transduction 0.00918313955379334 2772 39 14 0.358974358974359 0.00505050505050505
GO:BP GO:0031960 response to corticosteroid 0.00935542888592779 165 24 3 0.125 0.0181818181818182
GO:BP GO:0010035 response to inorganic substance 0.00951909889267205 575 39 6 0.153846153846154 0.0104347826086957
GO:BP GO:0048660 regulation of smooth muscle cell proliferation 0.00953851710151162 174 23 3 0.130434782608696 0.0172413793103448
GO:BP GO:1905039 carboxylic acid transmembrane transport 0.00960274419062302 154 26 3 0.115384615384615 0.0194805194805195
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.00962463541325217 3483 4 4 1 0.00114843525696239
GO:BP GO:0048659 smooth muscle cell proliferation 0.00969737371959359 176 23 3 0.130434782608696 0.0170454545454545
GO:BP GO:1903825 organic acid transmembrane transport 0.00969737371959359 155 26 3 0.115384615384615 0.0193548387096774
GO:BP GO:0098869 cellular oxidant detoxification 0.0102069902341672 100 41 3 0.0731707317073171 0.03
GO:BP GO:0050764 regulation of phagocytosis 0.0102944449923252 98 42 3 0.0714285714285714 0.0306122448979592
GO:BP GO:0043406 positive regulation of MAP kinase activity 0.0105586075343808 234 39 4 0.102564102564103 0.0170940170940171
GO:BP GO:1903792 negative regulation of anion transport 0.0106916140750576 235 39 4 0.102564102564103 0.0170212765957447
GO:BP GO:0098739 import across plasma membrane 0.0107071845794487 163 26 3 0.115384615384615 0.0184049079754601
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.0108416973536986 360 26 4 0.153846153846154 0.0111111111111111
GO:BP GO:0001101 response to acid chemical 0.0113293373657543 135 32 3 0.09375 0.0222222222222222
GO:BP GO:0009966 regulation of signal transduction 0.0113293373657543 3165 15 8 0.533333333333333 0.00252764612954186
GO:BP GO:0071674 mononuclear cell migration 0.011443242050925 191 23 3 0.130434782608696 0.0157068062827225
GO:BP GO:0042221 response to chemical 0.011443242050925 4781 41 20 0.48780487804878 0.00418322526668061
GO:BP GO:0002683 negative regulation of immune system process 0.0115960111228988 420 23 4 0.173913043478261 0.00952380952380952
GO:BP GO:0009893 positive regulation of metabolic process 0.0122397971351317 3783 4 4 1 0.00105736188210415
GO:BP GO:0065009 regulation of molecular function 0.0124095191919783 3221 15 8 0.533333333333333 0.00248370071406396
GO:BP GO:0001909 leukocyte mediated cytotoxicity 0.0124264470726975 107 42 3 0.0714285714285714 0.0280373831775701
GO:BP GO:0002688 regulation of leukocyte chemotaxis 0.0126748748588008 120 38 3 0.0789473684210526 0.025
GO:BP GO:1990748 cellular detoxification 0.0132680633916702 113 41 3 0.0731707317073171 0.0265486725663717
GO:BP GO:0009636 response to toxic substance 0.0134433958627676 243 41 4 0.0975609756097561 0.0164609053497942
GO:BP GO:0071310 cellular response to organic substance 0.013823833176121 2776 41 14 0.341463414634146 0.00504322766570605
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.0140986480567177 185 26 3 0.115384615384615 0.0162162162162162
GO:BP GO:0001952 regulation of cell-matrix adhesion 0.0144753531677659 127 38 3 0.0789473684210526 0.0236220472440945
GO:BP GO:1901654 response to ketone 0.0145509477735428 204 24 3 0.125 0.0147058823529412
GO:BP GO:0048878 chemical homeostasis 0.014587647475476 1229 15 5 0.333333333333333 0.00406834825061025
GO:BP GO:0009611 response to wounding 0.014587647475476 674 26 5 0.192307692307692 0.00741839762611276
GO:BP GO:0050790 regulation of catalytic activity 0.0147021353224068 2545 15 7 0.466666666666667 0.00275049115913556
GO:BP GO:0019220 regulation of phosphate metabolic process 0.0148368930115704 1645 40 10 0.25 0.0060790273556231
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.0148368930115704 1645 40 10 0.25 0.0060790273556231
GO:BP GO:0097237 cellular response to toxic substance 0.0149630735141188 120 41 3 0.0731707317073171 0.025
GO:BP GO:0051716 cellular response to stimulus 0.015316975341731 7781 41 27 0.658536585365854 0.00346999100372703
GO:BP GO:0032501 multicellular organismal process 0.0153522002860931 7946 16 13 0.8125 0.0016360432922225
GO:BP GO:0043269 regulation of ion transport 0.0154958745770214 1379 26 7 0.269230769230769 0.0050761421319797
GO:BP GO:0006805 xenobiotic metabolic process 0.0154958745770214 122 41 3 0.0731707317073171 0.0245901639344262
GO:BP GO:0051249 regulation of lymphocyte activation 0.0156320181188652 518 21 4 0.19047619047619 0.00772200772200772
GO:BP GO:0071495 cellular response to endogenous stimulus 0.0156588552467992 1422 32 8 0.25 0.00562587904360056
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0158826435757238 2541 3 3 1 0.00118063754427391
GO:BP GO:0006508 proteolysis 0.0161787335112115 1836 7 4 0.571428571428571 0.00217864923747277
GO:BP GO:0051049 regulation of transport 0.0164518406269467 1809 26 8 0.307692307692308 0.00442233278054174
GO:BP GO:0071466 cellular response to xenobiotic stimulus 0.016457660538444 127 41 3 0.0731707317073171 0.0236220472440945
GO:BP GO:1904062 regulation of cation transmembrane transport 0.016457660538444 360 15 3 0.2 0.00833333333333333
GO:BP GO:0001666 response to hypoxia 0.0164760891513566 367 30 4 0.133333333333333 0.0108991825613079
GO:BP GO:0044267 cellular protein metabolic process 0.0164760891513566 5229 13 9 0.692307692307692 0.00172117039586919
GO:BP GO:0065008 regulation of biological quality 0.0166050302662326 4131 42 18 0.428571428571429 0.00435729847494553
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.0172711800524234 141 38 3 0.0789473684210526 0.0212765957446809
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.0175309134693788 142 38 3 0.0789473684210526 0.0211267605633803
GO:BP GO:0051246 regulation of protein metabolic process 0.0176699650819626 2704 3 3 1 0.0011094674556213
GO:BP GO:0042325 regulation of phosphorylation 0.0178735253349037 1431 40 9 0.225 0.00628930817610063
GO:BP GO:0043408 regulation of MAPK cascade 0.017906029103692 730 26 5 0.192307692307692 0.00684931506849315
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 0.0179234159862786 503 23 4 0.173913043478261 0.00795228628230616
GO:BP GO:0009410 response to xenobiotic stimulus 0.0179265465244133 134 41 3 0.0731707317073171 0.0223880597014925
GO:BP GO:0098754 detoxification 0.0179265465244133 134 41 3 0.0731707317073171 0.0223880597014925
GO:BP GO:0036293 response to decreased oxygen levels 0.0179943145014505 382 30 4 0.133333333333333 0.0104712041884817
GO:BP GO:0006897 endocytosis 0.0180213670881612 696 39 6 0.153846153846154 0.00862068965517241
GO:BP GO:0033002 muscle cell proliferation 0.018066243894205 244 23 3 0.130434782608696 0.0122950819672131
GO:BP GO:0002699 positive regulation of immune effector process 0.018066243894205 215 26 3 0.115384615384615 0.013953488372093
GO:BP GO:0009725 response to hormone 0.0181150869792492 921 30 6 0.2 0.00651465798045603
GO:BP GO:0042592 homeostatic process 0.0181365515497853 1981 15 6 0.4 0.00302877334679455
GO:BP GO:0010646 regulation of cell communication 0.018393266146843 3543 18 9 0.5 0.00254022015241321
GO:BP GO:0009056 catabolic process 0.0184761247456473 2744 39 13 0.333333333333333 0.00473760932944606
GO:BP GO:0023051 regulation of signaling 0.0192292149701024 3578 18 9 0.5 0.00251537171604248
GO:BP GO:0002697 regulation of immune effector process 0.0194240291805623 461 26 4 0.153846153846154 0.00867678958785249
GO:BP GO:0032879 regulation of localization 0.0194240291805623 2872 42 14 0.333333333333333 0.00487465181058496
GO:BP GO:0006874 cellular calcium ion homeostasis 0.0194240291805623 460 26 4 0.153846153846154 0.00869565217391304
GO:BP GO:0043170 macromolecule metabolic process 0.0197451626156119 9796 13 12 0.923076923076923 0.00122498979175174
GO:BP GO:0014070 response to organic cyclic compound 0.0200033039348788 967 39 7 0.179487179487179 0.00723888314374354
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.0200265223629426 155 38 3 0.0789473684210526 0.0193548387096774
GO:BP GO:0055074 calcium ion homeostasis 0.0203158736498317 472 26 4 0.153846153846154 0.00847457627118644
GO:BP GO:0030155 regulation of cell adhesion 0.0203556775676058 748 38 6 0.157894736842105 0.00802139037433155
GO:BP GO:0070482 response to oxygen levels 0.0204586771761405 408 30 4 0.133333333333333 0.00980392156862745
GO:BP GO:0098657 import into cell 0.0207590799091621 235 26 3 0.115384615384615 0.0127659574468085
GO:BP GO:1903305 regulation of regulated secretory pathway 0.0207590799091621 144 42 3 0.0714285714285714 0.0208333333333333
GO:BP GO:0000187 activation of MAPK activity 0.0209278690813625 156 39 3 0.0769230769230769 0.0192307692307692
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0209422922689417 1132 26 6 0.230769230769231 0.00530035335689046
GO:BP GO:0071902 positive regulation of protein serine/threonine kinase activity 0.0209422922689417 316 39 4 0.102564102564103 0.0126582278481013
GO:BP GO:0009991 response to extracellular stimulus 0.0209422922689417 512 39 5 0.128205128205128 0.009765625
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0220985247459082 3083 3 3 1 0.000973078170613039
GO:BP GO:0071496 cellular response to external stimulus 0.0220985247459082 322 39 4 0.102564102564103 0.0124223602484472
GO:BP GO:0019538 protein metabolic process 0.0239806956368779 5808 7 6 0.857142857142857 0.00103305785123967
GO:BP GO:0045766 positive regulation of angiogenesis 0.0241165326518107 187 35 3 0.0857142857142857 0.0160427807486631
GO:BP GO:1904018 positive regulation of vasculature development 0.0241165326518107 187 35 3 0.0857142857142857 0.0160427807486631
GO:BP GO:0048522 positive regulation of cellular process 0.0244329317885221 5757 15 10 0.666666666666667 0.00173701580684384
GO:BP GO:0034614 cellular response to reactive oxygen species 0.0244329317885221 170 39 3 0.0769230769230769 0.0176470588235294
GO:BP GO:0043410 positive regulation of MAPK cascade 0.0244329317885221 539 39 5 0.128205128205128 0.00927643784786642
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.024802888670895 3274 3 3 1 0.000916310323762981
GO:BP GO:0001934 positive regulation of protein phosphorylation 0.0256955241853912 840 26 5 0.192307692307692 0.00595238095238095
GO:BP GO:0043271 negative regulation of ion transport 0.026794701061843 349 39 4 0.102564102564103 0.0114613180515759
GO:BP GO:0034097 response to cytokine 0.0273191590553779 1226 26 6 0.230769230769231 0.00489396411092985
GO:BP GO:0010468 regulation of gene expression 0.0273191590553779 5196 4 4 1 0.000769822940723634
GO:BP GO:0022008 neurogenesis 0.0275296448232867 1675 5 3 0.6 0.0017910447761194
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.0277505200218636 365 38 4 0.105263157894737 0.010958904109589
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 0.0290438281492865 3535 3 3 1 0.000848656294200849
GO:BP GO:0006355 regulation of transcription, DNA-templated 0.0290438281492865 3534 3 3 1 0.000848896434634975
GO:BP GO:2001141 regulation of RNA biosynthetic process 0.0290951223418147 3540 3 3 1 0.000847457627118644
GO:BP GO:0009719 response to endogenous stimulus 0.0294137744654269 1683 32 8 0.25 0.0047534165181224
GO:BP GO:0060627 regulation of vesicle-mediated transport 0.0295412520472384 536 42 5 0.119047619047619 0.00932835820895522
GO:BP GO:0036211 protein modification process 0.0295412520472384 4041 7 5 0.714285714285714 0.00123731749566939
GO:BP GO:0006464 cellular protein modification process 0.0295412520472384 4041 7 5 0.714285714285714 0.00123731749566939
GO:BP GO:0050864 regulation of B cell activation 0.0296342559494769 194 38 3 0.0789473684210526 0.0154639175257732
GO:BP GO:0044070 regulation of anion transport 0.0305729671164039 896 26 5 0.192307692307692 0.00558035714285714
GO:BP GO:0010038 response to metal ion 0.0305729671164039 371 39 4 0.102564102564103 0.0107816711590297
GO:BP GO:0045859 regulation of protein kinase activity 0.0307877796657354 809 40 6 0.15 0.00741656365883807
GO:BP GO:0046649 lymphocyte activation 0.0309684637413024 771 42 6 0.142857142857143 0.00778210116731518
GO:BP GO:0097659 nucleic acid-templated transcription 0.0317085009291643 3715 3 3 1 0.000807537012113055
GO:BP GO:0006351 transcription, DNA-templated 0.0317085009291643 3714 3 3 1 0.000807754442649435
GO:BP GO:0032774 RNA biosynthetic process 0.0319897245747104 3731 3 3 1 0.000804073974805682
GO:BP GO:0010941 regulation of cell death 0.0325356626170179 1720 26 7 0.269230769230769 0.00406976744186047
GO:BP GO:0006468 protein phosphorylation 0.0330778612945463 1668 40 9 0.225 0.00539568345323741
GO:BP GO:0042327 positive regulation of phosphorylation 0.0330778612945463 927 26 5 0.192307692307692 0.00539374325782093
GO:BP GO:0031399 regulation of protein modification process 0.0331102783394186 1671 40 9 0.225 0.00538599640933573
GO:BP GO:0051252 regulation of RNA metabolic process 0.0332629980742126 3822 3 3 1 0.000784929356357928
GO:BP GO:0000165 MAPK cascade 0.0338740269954681 935 26 5 0.192307692307692 0.0053475935828877
GO:BP GO:0043412 macromolecule modification 0.0341212941275838 4257 7 5 0.714285714285714 0.00117453605825699
GO:BP GO:0002685 regulation of leukocyte migration 0.0341212941275838 211 38 3 0.0789473684210526 0.014218009478673
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.0379797319069101 222 38 3 0.0789473684210526 0.0135135135135135
GO:BP GO:0015849 organic acid transport 0.0380829631223525 331 26 3 0.115384615384615 0.00906344410876133
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 0.0380829631223525 4091 3 3 1 0.000733317037399169
GO:BP GO:0061024 membrane organization 0.0380829631223525 973 26 5 0.192307692307692 0.00513874614594039
GO:BP GO:2000112 regulation of cellular macromolecule biosynthetic process 0.0380829631223525 4071 3 3 1 0.000736919675755343
GO:BP GO:0042127 regulation of cell population proliferation 0.0380829631223525 1774 39 9 0.230769230769231 0.00507328072153326
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 0.0382450673502739 4102 3 3 1 0.000731350560702097
GO:BP GO:0050920 regulation of chemotaxis 0.0385788683965819 226 38 3 0.0789473684210526 0.0132743362831858
GO:BP GO:0042493 response to drug 0.039398908200692 396 41 4 0.0975609756097561 0.0101010101010101
GO:BP GO:0017157 regulation of exocytosis 0.0395080176480849 207 42 3 0.0714285714285714 0.0144927536231884
GO:BP GO:0008219 cell death 0.0399780904340051 2292 26 8 0.307692307692308 0.00349040139616056
GO:BP GO:1901652 response to peptide 0.0401036468050285 551 30 4 0.133333333333333 0.00725952813067151
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 0.0402275879464206 4199 3 3 1 0.000714455822814956
GO:BP GO:0034220 ion transmembrane transport 0.0404489485072767 1397 26 6 0.230769230769231 0.00429491768074445
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.040450359654134 1001 26 5 0.192307692307692 0.004995004995005
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.040450359654134 1001 26 5 0.192307692307692 0.004995004995005
GO:BP GO:0007160 cell-matrix adhesion 0.0407947813546741 235 38 3 0.0789473684210526 0.0127659574468085
GO:BP GO:0051128 regulation of cellular component organization 0.0409190195419839 2412 40 11 0.275 0.00456053067993367
GO:BP GO:0018130 heterocycle biosynthetic process 0.0409190195419839 4269 3 3 1 0.000702740688685875
GO:BP GO:0031326 regulation of cellular biosynthetic process 0.0409266083400388 4273 3 3 1 0.000702082845775802
GO:BP GO:0019438 aromatic compound biosynthetic process 0.040940977774135 4278 3 3 1 0.000701262272089762
GO:BP GO:1901564 organonitrogen compound metabolic process 0.040940977774135 6792 7 6 0.857142857142857 0.00088339222614841
GO:BP GO:0010467 gene expression 0.0419016346935568 6179 4 4 1 0.000647353940767114
GO:BP GO:0009889 regulation of biosynthetic process 0.0427952388415624 4361 3 3 1 0.000687915615684476
GO:BP GO:0016485 protein processing 0.0427952388415624 235 39 3 0.0769230769230769 0.0127659574468085
GO:BP GO:0000302 response to reactive oxygen species 0.0433369882361299 237 39 3 0.0769230769230769 0.0126582278481013
GO:BP GO:0051239 regulation of multicellular organismal process 0.0442769190926873 2861 26 9 0.346153846153846 0.00314575323313527
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.0443515645831012 4439 3 3 1 0.000675827889164226
GO:BP GO:0043549 regulation of kinase activity 0.0446032955267715 921 40 6 0.15 0.00651465798045603
GO:BP GO:0009628 response to abiotic stimulus 0.0464946008620763 1261 30 6 0.2 0.00475812846946868
GO:BP GO:0031668 cellular response to extracellular stimulus 0.047285056058224 248 39 3 0.0769230769230769 0.0120967741935484
GO:BP GO:0008285 negative regulation of cell population proliferation 0.047285056058224 790 23 4 0.173913043478261 0.00506329113924051
GO:BP GO:0003012 muscle system process 0.047285056058224 471 21 3 0.142857142857143 0.00636942675159236
GO:BP GO:0051046 regulation of secretion 0.047285056058224 647 42 5 0.119047619047619 0.00772797527047913
GO:BP GO:0031401 positive regulation of protein modification process 0.0483511663010586 1074 26 5 0.192307692307692 0.00465549348230913
GO:BP GO:0016070 RNA metabolic process 0.0494137877918989 4710 3 3 1 0.000636942675159236
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.0494137877918989 6603 4 4 1 0.000605785249129184
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0498220421096547 470 39 4 0.102564102564103 0.00851063829787234
GO:BP GO:0043270 positive regulation of ion transport 0.0499865499352382 694 15 3 0.2 0.00432276657060519
GO:CC GO:0030141 secretory granule 4.24638667339631e-21 851 42 25 0.595238095238095 0.0293772032902468
GO:CC GO:0099503 secretory vesicle 6.47926982241936e-21 1020 42 26 0.619047619047619 0.0254901960784314
GO:CC GO:0031410 cytoplasmic vesicle 3.18161404827262e-15 2424 42 29 0.69047619047619 0.011963696369637
GO:CC GO:0097708 intracellular vesicle 3.18161404827262e-15 2428 42 29 0.69047619047619 0.0119439868204283
GO:CC GO:0031983 vesicle lumen 5.0982667058966e-12 326 42 13 0.30952380952381 0.0398773006134969
GO:CC GO:0034774 secretory granule lumen 5.0982667058966e-12 320 42 13 0.30952380952381 0.040625
GO:CC GO:0060205 cytoplasmic vesicle lumen 5.0982667058966e-12 324 42 13 0.30952380952381 0.0401234567901235
GO:CC GO:0070820 tertiary granule 3.7307065970391e-11 163 28 9 0.321428571428571 0.0552147239263804
GO:CC GO:0012505 endomembrane system 6.79078084182071e-11 4640 42 32 0.761904761904762 0.00689655172413793
GO:CC GO:0031982 vesicle 1.24868161716477e-10 4055 42 30 0.714285714285714 0.00739827373612824
GO:CC GO:0005773 vacuole 1.87150867416501e-09 810 42 15 0.357142857142857 0.0185185185185185
GO:CC GO:0101002 ficolin-1-rich granule 2.67011700542895e-09 184 40 9 0.225 0.0489130434782609
GO:CC GO:0000323 lytic vacuole 3.36670663408943e-09 712 42 14 0.333333333333333 0.0196629213483146
GO:CC GO:0005764 lysosome 3.36670663408943e-09 712 42 14 0.333333333333333 0.0196629213483146
GO:CC GO:0030667 secretory granule membrane 1.41531218737093e-08 303 42 10 0.238095238095238 0.033003300330033
GO:CC GO:0062023 collagen-containing extracellular matrix 4.71916453350668e-08 421 8 6 0.75 0.0142517814726841
GO:CC GO:1904813 ficolin-1-rich granule lumen 9.57232909210668e-08 124 40 7 0.175 0.0564516129032258
GO:CC GO:0030659 cytoplasmic vesicle membrane 9.78913304856386e-08 779 42 13 0.30952380952381 0.0166880616174583
GO:CC GO:0012506 vesicle membrane 1.27408992900501e-07 800 42 13 0.30952380952381 0.01625
GO:CC GO:0030312 external encapsulating structure 2.04812224221869e-07 563 8 6 0.75 0.0106571936056838
GO:CC GO:0031012 extracellular matrix 2.04812224221869e-07 562 8 6 0.75 0.0106761565836299
GO:CC GO:0042582 azurophil granule 3.81645149793897e-07 154 41 7 0.170731707317073 0.0454545454545455
GO:CC GO:0005766 primary lysosome 3.81645149793897e-07 154 41 7 0.170731707317073 0.0454545454545455
GO:CC GO:0042581 specific granule 5.2009858958202e-07 158 42 7 0.166666666666667 0.0443037974683544
GO:CC GO:0005615 extracellular space 5.73932935860912e-07 3594 10 10 1 0.00278241513633834
GO:CC GO:0071944 cell periphery 5.75369298340165e-07 6169 26 22 0.846153846153846 0.00356621818771276
GO:CC GO:0005775 vacuolar lumen 1.03131787610947e-06 174 14 5 0.357142857142857 0.028735632183908
GO:CC GO:0005576 extracellular region 1.74897983998512e-06 4567 42 26 0.619047619047619 0.00569301510838625
GO:CC GO:1904724 tertiary granule lumen 1.0280511951401e-05 55 28 4 0.142857142857143 0.0727272727272727
GO:CC GO:0005886 plasma membrane 3.52517198985819e-05 5681 42 27 0.642857142857143 0.00475268438655166
GO:CC GO:0035578 azurophil granule lumen 8.39830315090575e-05 91 29 4 0.137931034482759 0.043956043956044
GO:CC GO:0005737 cytoplasm 0.000123071564488954 11911 30 29 0.966666666666667 0.00243472420451683
GO:CC GO:0035579 specific granule membrane 0.000227128498314754 90 38 4 0.105263157894737 0.0444444444444444
GO:CC GO:0098588 bounding membrane of organelle 0.000231704037560515 2158 42 15 0.357142857142857 0.00695088044485635
GO:CC GO:0045335 phagocytic vesicle 0.000238341631332267 137 26 4 0.153846153846154 0.0291970802919708
GO:CC GO:0070062 extracellular exosome 0.000241482910644559 2176 42 15 0.357142857142857 0.00689338235294118
GO:CC GO:0043230 extracellular organelle 0.000362938052249517 2263 42 15 0.357142857142857 0.0066283694211224
GO:CC GO:1903561 extracellular vesicle 0.000362938052249517 2261 42 15 0.357142857142857 0.00663423264042459
GO:CC GO:0031974 membrane-enclosed lumen 0.00110474221737298 5565 7 7 1 0.00125786163522013
GO:CC GO:0043233 organelle lumen 0.00110474221737298 5565 7 7 1 0.00125786163522013
GO:CC GO:0031091 platelet alpha granule 0.00143165917692466 90 26 3 0.115384615384615 0.0333333333333333
GO:CC GO:0043227 membrane-bounded organelle 0.00327012144566884 12858 19 19 1 0.00147767926582672
GO:CC GO:0030139 endocytic vesicle 0.00386880353871586 306 26 4 0.153846153846154 0.0130718954248366
GO:CC GO:0030666 endocytic vesicle membrane 0.00658372347535776 159 26 3 0.115384615384615 0.0188679245283019
GO:CC GO:0005856 cytoskeleton 0.00850375756209599 2332 3 3 1 0.00128644939965695
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00850375756209599 11296 17 16 0.941176470588235 0.00141643059490085
GO:CC GO:0005774 vacuolar membrane 0.0108138317504299 441 41 5 0.121951219512195 0.0113378684807256
GO:CC GO:0005770 late endosome 0.0127789916146074 275 42 4 0.0952380952380952 0.0145454545454545
GO:CC GO:0031090 organelle membrane 0.0127789916146074 3612 42 16 0.380952380952381 0.0044296788482835
GO:CC GO:0043226 organelle 0.0127789916146074 14008 19 19 1 0.00135636778983438
GO:CC GO:0045121 membrane raft 0.0174696854640363 335 39 4 0.102564102564103 0.0119402985074627
GO:CC GO:0098857 membrane microdomain 0.0174696854640363 335 39 4 0.102564102564103 0.0119402985074627
GO:CC GO:0031225 anchored component of membrane 0.018016752513852 174 38 3 0.0789473684210526 0.0172413793103448
GO:CC GO:0005622 intracellular anatomical structure 0.0188964726419202 14790 30 29 0.966666666666667 0.00196078431372549
GO:CC GO:0009986 cell surface 0.0228198351844186 899 26 5 0.192307692307692 0.00556173526140156
GO:CC GO:0005794 Golgi apparatus 0.0250813426522362 1623 42 9 0.214285714285714 0.0055452865064695
GO:CC GO:0043229 intracellular organelle 0.0250813426522362 12491 17 16 0.941176470588235 0.0012809222640301
GO:CC GO:0098552 side of membrane 0.0250813426522362 619 39 5 0.128205128205128 0.00807754442649435
GO:CC GO:0016020 membrane 0.0250813426522362 9838 42 30 0.714285714285714 0.00304940028461069
GO:CC GO:0098852 lytic vacuole membrane 0.0265332557839063 383 41 4 0.0975609756097561 0.010443864229765
GO:CC GO:0005765 lysosomal membrane 0.0265332557839063 383 41 4 0.0975609756097561 0.010443864229765
GO:CC GO:0048471 perinuclear region of cytoplasm 0.034874711216862 735 24 4 0.166666666666667 0.0054421768707483
GO:CC GO:0045177 apical part of cell 0.0392417982804052 431 42 4 0.0952380952380952 0.00928074245939675
GO:CC GO:0009897 external side of plasma membrane 0.044918292453358 408 26 3 0.115384615384615 0.00735294117647059
GO:CC GO:0070013 intracellular organelle lumen 0.0455040552884113 5402 16 9 0.5625 0.00166604961125509
GO:CC GO:0043005 neuron projection 0.0492264705408202 1380 15 4 0.266666666666667 0.00289855072463768
GO:MF GO:0050786 RAGE receptor binding 3.28823850804515e-12 11 11 5 0.454545454545455 0.454545454545455
GO:MF GO:0048306 calcium-dependent protein binding 3.34887060199102e-06 82 8 4 0.5 0.0487804878048781
GO:MF GO:0005509 calcium ion binding 6.64719223441803e-06 721 23 9 0.391304347826087 0.0124826629680999
GO:MF GO:0038187 pattern recognition receptor activity 0.00011569841706279 24 26 3 0.115384615384615 0.125
GO:MF GO:0031406 carboxylic acid binding 0.00011569841706279 194 4 3 0.75 0.0154639175257732
GO:MF GO:0005102 signaling receptor binding 0.00124646817866301 1672 4 4 1 0.00239234449760766
GO:MF GO:0008270 zinc ion binding 0.00151887296266651 833 3 3 1 0.00360144057623049
GO:MF GO:0030246 carbohydrate binding 0.00291978121670646 275 37 5 0.135135135135135 0.0181818181818182
GO:MF GO:0046914 transition metal ion binding 0.00291978121670646 1111 3 3 1 0.0027002700270027
GO:MF GO:0046872 metal ion binding 0.00433410704574821 4260 39 19 0.487179487179487 0.00446009389671361
GO:MF GO:0008289 lipid binding 0.00489567803804616 776 34 7 0.205882352941176 0.00902061855670103
GO:MF GO:0043169 cation binding 0.00510519097210815 4351 39 19 0.487179487179487 0.00436681222707424
GO:MF GO:0008092 cytoskeletal protein binding 0.0115205555117186 996 42 8 0.19047619047619 0.00803212851405622
GO:MF GO:0020037 heme binding 0.0149747539693533 144 35 3 0.0857142857142857 0.0208333333333333
GO:MF GO:0046906 tetrapyrrole binding 0.0169800849416292 154 35 3 0.0857142857142857 0.0194805194805195
GO:MF GO:0005515 protein binding 0.0186559890257537 14767 34 33 0.970588235294118 0.00223471253470576
GO:MF GO:0043167 ion binding 0.019380858182865 6057 5 5 1 0.00082549116724451
GO:MF GO:0043168 anion binding 0.0331383093228118 2418 4 3 0.75 0.00124069478908189
GO:MF GO:0016829 lyase activity 0.0336628765763456 203 38 3 0.0789473684210526 0.0147783251231527
GO:MF GO:0005539 glycosaminoglycan binding 0.036065087195791 238 34 3 0.0882352941176471 0.0126050420168067
GO:MF GO:0016787 hydrolase activity 0.0387867126901942 2615 42 12 0.285714285714286 0.00458891013384321
GO:MF GO:0046982 protein heterodimerization activity 0.0387867126901942 357 24 3 0.125 0.00840336134453781
HP HP:0004311 Abnormal macrophage morphology 0.0178820486115563 33 42 4 0.0952380952380952 0.121212121212121
HPA HPA:0040083 bone marrow; hematopoietic cells[High] 0.000595313591699054 1376 21 12 0.571428571428571 0.00872093023255814
HPA HPA:0530712 spleen; cells in red pulp[≥Medium] 0.00187984516718062 3049 9 9 1 0.00295178747130207
HPA HPA:0530713 spleen; cells in red pulp[High] 0.00187984516718062 778 23 9 0.391304347826087 0.0115681233933162
HPA HPA:0040082 bone marrow; hematopoietic cells[≥Medium] 0.00888572875907305 4126 30 22 0.733333333333333 0.00533204071740184
KEGG KEGG:04145 Phagosome 0.00477405949256343 147 26 5 0.192307692307692 0.0340136054421769
REAC REAC:R-HSA-6798695 Neutrophil degranulation 2.77783224421776e-18 474 42 23 0.547619047619048 0.0485232067510548
REAC REAC:R-HSA-168249 Innate Immune System 7.83196236285552e-12 1073 42 24 0.571428571428571 0.0223671947809879
REAC REAC:R-HSA-168256 Immune System 1.52671444969106e-07 2139 29 21 0.724137931034483 0.00981767180925666
REAC REAC:R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 1.1921492314056e-05 24 24 4 0.166666666666667 0.166666666666667
REAC REAC:R-HSA-168898 Toll-like Receptor Cascades 2.27439051892711e-05 152 6 4 0.666666666666667 0.0263157894736842
REAC REAC:R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes) 2.36666625606449e-05 8 26 3 0.115384615384615 0.375
REAC REAC:R-HSA-1236975 Antigen processing-Cross presentation 0.0020902571913712 99 26 4 0.153846153846154 0.0404040404040404
REAC REAC:R-HSA-114608 Platelet degranulation 0.00468395049768542 125 26 4 0.153846153846154 0.032
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.00499046998203422 130 26 4 0.153846153846154 0.0307692307692308
REAC REAC:R-HSA-166658 Complement cascade 0.0155736196718586 111 19 3 0.157894736842105 0.027027027027027
REAC REAC:R-HSA-76002 Platelet activation, signaling and aggregation 0.0314342593507016 258 26 4 0.153846153846154 0.0155038759689922
TF TF:M01869 Factor: C/EBPgamma; motif: NRTKRSRMAAKN 0.007742521819913 3194 15 11 0.733333333333333 0.00344395742016281
TF TF:M01010 Factor: HMGIY; motif: NNKKNAWTTTNYTNN 0.0134058238617002 8254 24 21 0.875 0.00254422098376545
TF TF:M01119_1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 1 0.0151612674654422 542 19 6 0.315789473684211 0.011070110701107
TF TF:M00205 Factor: GR; motif: GGTACAANNTGTYCTK 0.0234634186682691 6653 18 15 0.833333333333333 0.00225462197504885
TF TF:M01655 Factor: p53; motif: GGACATGYYCGGACATGYYC 0.0234634186682691 3419 12 9 0.75 0.0026323486399532
TF TF:M07228 Factor: STAT1; motif: NTTCYRGGAAA 0.0423163449057565 1919 9 6 0.666666666666667 0.00312662845231892
TF TF:M11568 Factor: HNF-3alpha; motif: NNYTAWGTAAACAAAN 0.0423163449057565 2277 14 8 0.571428571428571 0.00351339481774264
TF TF:M07080 Factor: C/EBPbeta; motif: KATTGCAYMAY 0.046143463160882 2026 39 13 0.333333333333333 0.00641658440276407
TF TF:M00447 Factor: AR; motif: AGWACATNWTGTTCT 0.046143463160882 4183 14 10 0.714285714285714 0.0023906287353574
TF TF:M00954 Factor: PR; motif: NNNNNNGGNACRNNNTGTTCTNNNNNN 0.046143463160882 5469 10 9 0.9 0.00164563905650027
WP WP:WP2806 Human Complement System 0.000302520840999814 99 34 6 0.176470588235294 0.0606060606060606
WP WP:WP3937 Microglia Pathogen Phagocytosis Pathway 0.00905582947127805 40 24 3 0.125 0.075

pM16 transcription factor target enrichment of top program genes

TF enrichment of pM16
TFs corrosponding to activation of pM16. (Left) pearson correlation of TF expression and gene expression program activatity in Myeloid cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.