pS07 program activity among Stromal cells

Activation of pS07
pS07 gene program activation in Stromal cells.
Gene program activation of pS07 by different cell subtypes
pS07 gene program activation among cells of different subtypes (Stromal cells).

pS07 top program genes

Top genes of pS07 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS07 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS07
pS07 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0030198 extracellular matrix organization 1.11050634420306e-11 401 81 19 0.234567901234568 0.0473815461346633
GO:BP GO:0045229 external encapsulating structure organization 1.11050634420306e-11 404 81 19 0.234567901234568 0.047029702970297
GO:BP GO:0043062 extracellular structure organization 1.11050634420306e-11 402 81 19 0.234567901234568 0.0472636815920398
GO:BP GO:0001501 skeletal system development 4.77170562843829e-09 504 81 18 0.222222222222222 0.0357142857142857
GO:BP GO:0030199 collagen fibril organization 3.93094211512357e-06 58 81 7 0.0864197530864197 0.120689655172414
GO:BP GO:0007275 multicellular organism development 1.05037656931863e-05 5613 21 19 0.904761904761905 0.00338499910921076
GO:BP GO:1903053 regulation of extracellular matrix organization 2.33084820072163e-05 47 80 6 0.075 0.127659574468085
GO:BP GO:0072359 circulatory system development 2.67685202917519e-05 1194 91 22 0.241758241758242 0.0184254606365159
GO:BP GO:0048856 anatomical structure development 3.22573536323803e-05 6106 21 19 0.904761904761905 0.00311169341631182
GO:BP GO:0051216 cartilage development 6.44975443140041e-05 196 81 9 0.111111111111111 0.0459183673469388
GO:BP GO:0032502 developmental process 0.000115795958954508 6628 21 19 0.904761904761905 0.00286662643331322
GO:BP GO:0022617 extracellular matrix disassembly 0.000122296104226206 82 15 4 0.266666666666667 0.0487804878048781
GO:BP GO:0001944 vasculature development 0.000141902839590766 830 91 17 0.186813186813187 0.0204819277108434
GO:BP GO:0048731 system development 0.000141902839590766 5052 21 17 0.80952380952381 0.00336500395882819
GO:BP GO:0035295 tube development 0.000149384579751271 1146 91 20 0.21978021978022 0.0174520069808028
GO:BP GO:0048771 tissue remodeling 0.000238844756704676 186 20 5 0.25 0.0268817204301075
GO:BP GO:0030111 regulation of Wnt signaling pathway 0.000238844756704676 376 103 12 0.116504854368932 0.0319148936170213
GO:BP GO:0001503 ossification 0.000238844756704676 417 10 5 0.5 0.0119904076738609
GO:BP GO:0001568 blood vessel development 0.00027003609054508 792 91 16 0.175824175824176 0.0202020202020202
GO:BP GO:0030154 cell differentiation 0.00027003609054508 4350 31 20 0.645161290322581 0.00459770114942529
GO:BP GO:0045595 regulation of cell differentiation 0.00027003609054508 1679 23 11 0.478260869565217 0.00655151876116736
GO:BP GO:0061448 connective tissue development 0.000273226409028388 256 81 9 0.111111111111111 0.03515625
GO:BP GO:0048869 cellular developmental process 0.000314093128805049 4428 31 20 0.645161290322581 0.004516711833785
GO:BP GO:0032501 multicellular organismal process 0.000314093128805049 7946 23 21 0.91304347826087 0.00264283916435943
GO:BP GO:0009887 animal organ morphogenesis 0.000366588840824872 1073 23 9 0.391304347826087 0.00838769804287046
GO:BP GO:0048513 animal organ development 0.000367983657549034 3672 23 15 0.652173913043478 0.00408496732026144
GO:BP GO:0030574 collagen catabolic process 0.000367983657549034 47 12 3 0.25 0.0638297872340425
GO:BP GO:0007155 cell adhesion 0.000389848783457293 1492 32 12 0.375 0.00804289544235925
GO:BP GO:0022610 biological adhesion 0.000389848783457293 1499 106 24 0.226415094339623 0.0160106737825217
GO:BP GO:0035239 tube morphogenesis 0.000389848783457293 950 91 17 0.186813186813187 0.0178947368421053
GO:BP GO:0006029 proteoglycan metabolic process 0.000423069268064331 89 51 5 0.0980392156862745 0.0561797752808989
GO:BP GO:0016055 Wnt signaling pathway 0.000538412210820518 529 115 14 0.121739130434783 0.0264650283553875
GO:BP GO:0198738 cell-cell signaling by wnt 0.000546412212720479 531 115 14 0.121739130434783 0.0263653483992467
GO:BP GO:0046849 bone remodeling 0.000557355913285198 93 8 3 0.375 0.032258064516129
GO:BP GO:0045597 positive regulation of cell differentiation 0.000573144380789875 879 23 8 0.347826086956522 0.00910125142207053
GO:BP GO:0002062 chondrocyte differentiation 0.000647217339482165 108 81 6 0.0740740740740741 0.0555555555555556
GO:BP GO:0002063 chondrocyte development 0.000666146532654433 30 81 4 0.0493827160493827 0.133333333333333
GO:BP GO:0048514 blood vessel morphogenesis 0.000821798772441467 711 91 14 0.153846153846154 0.019690576652602
GO:BP GO:0048468 cell development 0.00109267996709587 2100 35 14 0.4 0.00666666666666667
GO:BP GO:0009888 tissue development 0.00109267996709587 2107 127 32 0.251968503937008 0.015187470336972
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 0.00124277682976822 298 21 5 0.238095238095238 0.0167785234899329
GO:BP GO:0060070 canonical Wnt signaling pathway 0.00153749049060556 345 46 7 0.152173913043478 0.0202898550724638
GO:BP GO:0044273 sulfur compound catabolic process 0.00164315986557263 54 20 3 0.15 0.0555555555555556
GO:BP GO:0042127 regulation of cell population proliferation 0.00164315986557263 1774 37 13 0.351351351351351 0.00732807215332582
GO:BP GO:0060348 bone development 0.00182682315860478 203 109 8 0.073394495412844 0.0394088669950739
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 0.00194031553951893 218 103 8 0.0776699029126214 0.036697247706422
GO:BP GO:0097084 vascular associated smooth muscle cell development 0.00194031553951893 10 122 3 0.0245901639344262 0.3
GO:BP GO:0006027 glycosaminoglycan catabolic process 0.00218996727136551 61 20 3 0.15 0.0491803278688525
GO:BP GO:0090596 sensory organ morphogenesis 0.00224713425561823 262 65 7 0.107692307692308 0.0267175572519084
GO:BP GO:0009653 anatomical structure morphogenesis 0.00236974429177243 2797 23 12 0.521739130434783 0.00429031104755095
GO:BP GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 0.00236974429177243 636 86 12 0.13953488372093 0.0188679245283019
GO:BP GO:0032963 collagen metabolic process 0.00262052084619537 114 12 3 0.25 0.0263157894736842
GO:BP GO:0006026 aminoglycan catabolic process 0.00264807746564863 67 20 3 0.15 0.0447761194029851
GO:BP GO:0031589 cell-substrate adhesion 0.00382089481328124 367 23 5 0.217391304347826 0.0136239782016349
GO:BP GO:0042340 keratan sulfate catabolic process 0.00396960966431968 12 138 3 0.0217391304347826 0.25
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.00396960966431968 1202 91 17 0.186813186813187 0.0141430948419301
GO:BP GO:0034446 substrate adhesion-dependent cell spreading 0.00396960966431968 109 15 3 0.2 0.0275229357798165
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 0.0040744386727055 124 67 5 0.0746268656716418 0.0403225806451613
GO:BP GO:0008283 cell population proliferation 0.00409409777992525 2054 23 10 0.434782608695652 0.00486854917234664
GO:BP GO:0006508 proteolysis 0.00411692752891744 1836 40 13 0.325 0.00708061002178649
GO:BP GO:0060688 regulation of morphogenesis of a branching structure 0.00464374199940817 50 35 3 0.0857142857142857 0.06
GO:BP GO:0048844 artery morphogenesis 0.00464374199940817 77 23 3 0.130434782608696 0.038961038961039
GO:BP GO:0045785 positive regulation of cell adhesion 0.00470557241785705 437 80 9 0.1125 0.0205949656750572
GO:BP GO:0050793 regulation of developmental process 0.00482006292002992 2605 23 11 0.478260869565217 0.00422264875239923
GO:BP GO:1903055 positive regulation of extracellular matrix organization 0.00482817659977275 23 80 3 0.0375 0.130434782608696
GO:BP GO:0042063 gliogenesis 0.00482817659977275 308 30 5 0.166666666666667 0.0162337662337662
GO:BP GO:0050673 epithelial cell proliferation 0.00489227008497188 460 77 9 0.116883116883117 0.0195652173913043
GO:BP GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 0.0049391220759634 26 72 3 0.0416666666666667 0.115384615384615
GO:BP GO:0000413 protein peptidyl-prolyl isomerization 0.00499679428451482 44 111 4 0.036036036036036 0.0909090909090909
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.00500914587111436 284 18 4 0.222222222222222 0.0140845070422535
GO:BP GO:0051094 positive regulation of developmental process 0.00503073471072797 1341 23 8 0.347826086956522 0.00596569724086503
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.00509460749967884 222 23 4 0.173913043478261 0.018018018018018
GO:BP GO:2000026 regulation of multicellular organismal development 0.00514770141304808 1447 127 23 0.181102362204724 0.0158949550794748
GO:BP GO:0048706 embryonic skeletal system development 0.00514770141304808 123 76 5 0.0657894736842105 0.040650406504065
GO:BP GO:0007423 sensory organ development 0.00552199617469134 567 65 9 0.138461538461538 0.0158730158730159
GO:BP GO:0048598 embryonic morphogenesis 0.00552199617469134 595 76 10 0.131578947368421 0.0168067226890756
GO:BP GO:0002687 positive regulation of leukocyte migration 0.00553821170456578 137 70 5 0.0714285714285714 0.0364963503649635
GO:BP GO:0016331 morphogenesis of embryonic epithelium 0.00580526581550471 151 35 4 0.114285714285714 0.0264900662251656
GO:BP GO:0006024 glycosaminoglycan biosynthetic process 0.00608028544871016 107 20 3 0.15 0.0280373831775701
GO:BP GO:0021782 glial cell development 0.00640503077746284 122 18 3 0.166666666666667 0.0245901639344262
GO:BP GO:0048592 eye morphogenesis 0.006592540227793 155 65 5 0.0769230769230769 0.032258064516129
GO:BP GO:0048729 tissue morphogenesis 0.00669568032263827 667 35 7 0.2 0.0104947526236882
GO:BP GO:0035987 endodermal cell differentiation 0.00669568032263827 45 123 4 0.032520325203252 0.0888888888888889
GO:BP GO:0006023 aminoglycan biosynthetic process 0.00675211065682059 114 20 3 0.15 0.0263157894736842
GO:BP GO:0001525 angiogenesis 0.00675211065682059 617 91 11 0.120879120879121 0.0178282009724473
GO:BP GO:1905330 regulation of morphogenesis of an epithelium 0.00675211065682059 64 35 3 0.0857142857142857 0.046875
GO:BP GO:0030177 positive regulation of Wnt signaling pathway 0.00675211065682059 184 31 4 0.129032258064516 0.0217391304347826
GO:BP GO:1903510 mucopolysaccharide metabolic process 0.00688868880058898 116 20 3 0.15 0.0258620689655172
GO:BP GO:0016477 cell migration 0.00690958096529364 1649 8 5 0.625 0.00303214069132808
GO:BP GO:0009790 embryo development 0.00690958096529364 1035 65 12 0.184615384615385 0.0115942028985507
GO:BP GO:0060840 artery development 0.00700609609363547 102 23 3 0.130434782608696 0.0294117647058824
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00753631357333958 1455 35 10 0.285714285714286 0.00687285223367698
GO:BP GO:0007399 nervous system development 0.00933851801816934 2449 35 13 0.371428571428571 0.00530828909759085
GO:BP GO:0030595 leukocyte chemotaxis 0.00945301165603616 227 77 6 0.0779220779220779 0.026431718061674
GO:BP GO:0051674 localization of cell 0.00998255123608123 1828 8 5 0.625 0.00273522975929978
GO:BP GO:0048870 cell motility 0.00998255123608123 1828 8 5 0.625 0.00273522975929978
GO:BP GO:0051239 regulation of multicellular organismal process 0.0100711971238658 2861 31 13 0.419354838709677 0.00454386578119539
GO:BP GO:0002690 positive regulation of leukocyte chemotaxis 0.0100711971238658 93 70 4 0.0571428571428571 0.043010752688172
GO:BP GO:0071495 cellular response to endogenous stimulus 0.0104920805312506 1422 81 16 0.197530864197531 0.0112517580872011
GO:BP GO:0010001 glial cell differentiation 0.0104920805312506 225 30 4 0.133333333333333 0.0177777777777778
GO:BP GO:0001706 endoderm formation 0.0104920805312506 54 123 4 0.032520325203252 0.0740740740740741
GO:BP GO:0018208 peptidyl-proline modification 0.0111084808736323 61 111 4 0.036036036036036 0.0655737704918033
GO:BP GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 0.0111084808736323 40 72 3 0.0416666666666667 0.075
GO:BP GO:0007507 heart development 0.0111084808736323 578 122 12 0.0983606557377049 0.0207612456747405
GO:BP GO:0070848 response to growth factor 0.0111778033513983 759 81 11 0.135802469135802 0.0144927536231884
GO:BP GO:0002009 morphogenesis of an epithelium 0.012933008550714 560 35 6 0.171428571428571 0.0107142857142857
GO:BP GO:0050767 regulation of neurogenesis 0.012933008550714 366 35 5 0.142857142857143 0.0136612021857923
GO:BP GO:0090263 positive regulation of canonical Wnt signaling pathway 0.0132523593658311 151 21 3 0.142857142857143 0.0198675496688742
GO:BP GO:0030203 glycosaminoglycan metabolic process 0.0132523593658311 159 20 3 0.15 0.0188679245283019
GO:BP GO:0022008 neurogenesis 0.0138638070205363 1675 18 7 0.388888888888889 0.00417910447761194
GO:BP GO:0040011 locomotion 0.0138815698695991 2028 8 5 0.625 0.002465483234714
GO:BP GO:0021953 central nervous system neuron differentiation 0.0139370882687809 188 143 7 0.048951048951049 0.0372340425531915
GO:BP GO:0051093 negative regulation of developmental process 0.0140850705371707 977 144 18 0.125 0.0184237461617195
GO:BP GO:0030510 regulation of BMP signaling pathway 0.0142481568571459 96 34 3 0.0882352941176471 0.03125
GO:BP GO:0002685 regulation of leukocyte migration 0.0143210479690227 211 16 3 0.1875 0.014218009478673
GO:BP GO:0048518 positive regulation of biological process 0.0145321244796941 6363 23 16 0.695652173913043 0.00251453716800251
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0147146561093908 445 18 4 0.222222222222222 0.00898876404494382
GO:BP GO:0001822 kidney development 0.014881431129101 293 46 5 0.108695652173913 0.0170648464163823
GO:BP GO:0006022 aminoglycan metabolic process 0.0150300183270938 173 20 3 0.15 0.0173410404624277
GO:BP GO:0060415 muscle tissue morphogenesis 0.0158767869845587 69 51 3 0.0588235294117647 0.0434782608695652
GO:BP GO:0050678 regulation of epithelial cell proliferation 0.0158767869845587 401 35 5 0.142857142857143 0.0124688279301746
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0158767869845587 790 37 7 0.189189189189189 0.00886075949367089
GO:BP GO:0072001 renal system development 0.0158767869845587 302 46 5 0.108695652173913 0.0165562913907285
GO:BP GO:0048522 positive regulation of cellular process 0.0159885582768431 5757 23 15 0.652173913043478 0.00260552371026576
GO:BP GO:0022411 cellular component disassembly 0.0160781462914396 571 15 4 0.266666666666667 0.00700525394045534
GO:BP GO:0048568 embryonic organ development 0.0160843890471307 432 9 3 0.333333333333333 0.00694444444444444
GO:BP GO:0007267 cell-cell signaling 0.0163122494342005 1722 86 18 0.209302325581395 0.0104529616724739
GO:BP GO:0048593 camera-type eye morphogenesis 0.0165826056980371 126 65 4 0.0615384615384615 0.0317460317460317
GO:BP GO:0022612 gland morphogenesis 0.0166016828764167 120 31 3 0.0967741935483871 0.025
GO:BP GO:0016043 cellular component organization 0.0166016828764167 6566 21 15 0.714285714285714 0.0022844958879074
GO:BP GO:0044272 sulfur compound biosynthetic process 0.0174428960672245 193 20 3 0.15 0.0155440414507772
GO:BP GO:0031099 regeneration 0.017849565048034 206 19 3 0.157894736842105 0.0145631067961165
GO:BP GO:0050870 positive regulation of T cell activation 0.0178996306676558 219 18 3 0.166666666666667 0.0136986301369863
GO:BP GO:1901136 carbohydrate derivative catabolic process 0.0178996306676558 196 20 3 0.15 0.0153061224489796
GO:BP GO:0048644 muscle organ morphogenesis 0.0179729926781772 76 51 3 0.0588235294117647 0.0394736842105263
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 0.0179729926781772 187 21 3 0.142857142857143 0.0160427807486631
GO:BP GO:0030335 positive regulation of cell migration 0.0179729926781772 567 16 4 0.25 0.00705467372134039
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 0.0179794102314096 119 72 4 0.0555555555555556 0.0336134453781513
GO:BP GO:0030334 regulation of cell migration 0.0180660190650594 999 16 5 0.3125 0.005005005005005
GO:BP GO:0006928 movement of cell or subcellular component 0.0182093173227028 2311 8 5 0.625 0.00216356555603635
GO:BP GO:0060420 regulation of heart growth 0.0188517316989376 85 103 4 0.0388349514563107 0.0470588235294118
GO:BP GO:0048732 gland development 0.0188517316989376 436 35 5 0.142857142857143 0.0114678899082569
GO:BP GO:2000242 negative regulation of reproductive process 0.0195267270068794 61 67 3 0.0447761194029851 0.0491803278688525
GO:BP GO:2000147 positive regulation of cell motility 0.0195267270068794 591 16 4 0.25 0.00676818950930626
GO:BP GO:0051960 regulation of nervous system development 0.019705047302519 443 35 5 0.142857142857143 0.0112866817155756
GO:BP GO:0071363 cellular response to growth factor stimulus 0.019705047302519 731 81 10 0.123456790123457 0.0136798905608755
GO:BP GO:0007492 endoderm development 0.0198709644257201 80 52 3 0.0576923076923077 0.0375
GO:BP GO:0071840 cellular component organization or biogenesis 0.0198709644257201 6760 21 15 0.714285714285714 0.0022189349112426
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 0.0198709644257201 315 72 6 0.0833333333333333 0.019047619047619
GO:BP GO:0001655 urogenital system development 0.0199235310622343 337 46 5 0.108695652173913 0.0148367952522255
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 0.0199849876539324 1042 16 5 0.3125 0.00479846449136276
GO:BP GO:0040017 positive regulation of locomotion 0.0200098303889832 606 16 4 0.25 0.0066006600660066
GO:BP GO:0051272 positive regulation of cellular component movement 0.0200098303889832 604 16 4 0.25 0.00662251655629139
GO:BP GO:0019538 protein metabolic process 0.0200098303889832 5808 37 21 0.567567567567568 0.00361570247933884
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.0200098303889832 241 18 3 0.166666666666667 0.012448132780083
GO:BP GO:2000145 regulation of cell motility 0.0207556231579866 1061 16 5 0.3125 0.00471253534401508
GO:BP GO:0071548 response to dexamethasone 0.0211945033641823 40 110 3 0.0272727272727273 0.075
GO:BP GO:0120035 regulation of plasma membrane bounded cell projection organization 0.0226571181302125 638 16 4 0.25 0.00626959247648903
GO:BP GO:1903828 negative regulation of cellular protein localization 0.0229134058943977 116 139 5 0.0359712230215827 0.0431034482758621
GO:BP GO:0060326 cell chemotaxis 0.0232824710250532 310 77 6 0.0779220779220779 0.0193548387096774
GO:BP GO:0040012 regulation of locomotion 0.0233914917210838 1104 16 5 0.3125 0.00452898550724638
GO:BP GO:0001938 positive regulation of endothelial cell proliferation 0.0235486132938613 113 144 5 0.0347222222222222 0.0442477876106195
GO:BP GO:0071156 regulation of cell cycle arrest 0.0235486132938613 115 85 4 0.0470588235294118 0.0347826086956522
GO:BP GO:0050766 positive regulation of phagocytosis 0.0237051052674408 67 69 3 0.0434782608695652 0.0447761194029851
GO:BP GO:0030155 regulation of cell adhesion 0.0237051052674408 748 23 5 0.217391304347826 0.00668449197860963
GO:BP GO:0045765 regulation of angiogenesis 0.0238045386914184 358 91 7 0.0769230769230769 0.0195530726256983
GO:BP GO:0031344 regulation of cell projection organization 0.0238494900244329 656 16 4 0.25 0.00609756097560976
GO:BP GO:0001654 eye development 0.0248607236427154 379 65 6 0.0923076923076923 0.0158311345646438
GO:BP GO:1901342 regulation of vasculature development 0.0248607236427154 364 91 7 0.0769230769230769 0.0192307692307692
GO:BP GO:0051270 regulation of cellular component movement 0.0248607236427154 1141 16 5 0.3125 0.00438212094653812
GO:BP GO:0002684 positive regulation of immune system process 0.0248607236427154 1065 80 12 0.15 0.0112676056338028
GO:BP GO:0051604 protein maturation 0.0251384959065655 306 81 6 0.0740740740740741 0.0196078431372549
GO:BP GO:0052547 regulation of peptidase activity 0.0251384959065655 467 37 5 0.135135135135135 0.0107066381156317
GO:BP GO:0150063 visual system development 0.0251384959065655 383 65 6 0.0923076923076923 0.0156657963446475
GO:BP GO:0097529 myeloid leukocyte migration 0.0252381409376231 221 77 5 0.0649350649350649 0.0226244343891403
GO:BP GO:0051130 positive regulation of cellular component organization 0.0258548094776694 1153 23 6 0.260869565217391 0.00520381613183001
GO:BP GO:0060284 regulation of cell development 0.0260177644114638 502 35 5 0.142857142857143 0.0099601593625498
GO:BP GO:0048880 sensory system development 0.0263814593605686 389 65 6 0.0923076923076923 0.0154241645244216
GO:BP GO:0009719 response to endogenous stimulus 0.0275756435016057 1683 81 16 0.197530864197531 0.0095068330362448
GO:BP GO:1901652 response to peptide 0.0275756435016057 551 10 3 0.3 0.00544464609800363
GO:BP GO:0035886 vascular associated smooth muscle cell differentiation 0.0285790614235787 43 122 3 0.0245901639344262 0.0697674418604651
GO:BP GO:0060429 epithelium development 0.0293556419581278 1325 21 6 0.285714285714286 0.00452830188679245
GO:BP GO:0007417 central nervous system development 0.0293556419581278 1032 35 7 0.2 0.00678294573643411
GO:BP GO:0030509 BMP signaling pathway 0.0296131536532564 158 34 3 0.0882352941176471 0.0189873417721519
GO:BP GO:1901564 organonitrogen compound metabolic process 0.0297714127353119 6792 20 14 0.7 0.00206124852767962
GO:BP GO:0001837 epithelial to mesenchymal transition 0.0304548732776683 156 35 3 0.0857142857142857 0.0192307692307692
GO:BP GO:0050854 regulation of antigen receptor-mediated signaling pathway 0.0304548732776683 68 80 3 0.0375 0.0441176470588235
GO:BP GO:1903317 regulation of protein maturation 0.0304548732776683 68 80 3 0.0375 0.0441176470588235
GO:BP GO:0048705 skeletal system morphogenesis 0.0308044297396477 226 81 5 0.0617283950617284 0.0221238938053097
GO:BP GO:0032835 glomerulus development 0.0308044297396477 62 89 3 0.0337078651685393 0.0483870967741935
GO:BP GO:0006986 response to unfolded protein 0.0308044297396477 184 144 6 0.0416666666666667 0.0326086956521739
GO:BP GO:0050865 regulation of cell activation 0.0308044297396477 655 18 4 0.222222222222222 0.00610687022900763
GO:BP GO:0000904 cell morphogenesis involved in differentiation 0.0308044297396477 749 16 4 0.25 0.00534045393858478
GO:BP GO:0032526 response to retinoic acid 0.0308044297396477 110 50 3 0.06 0.0272727272727273
GO:BP GO:0060562 epithelial tube morphogenesis 0.0309609027266532 329 35 4 0.114285714285714 0.0121580547112462
GO:BP GO:0046620 regulation of organ growth 0.0314295462688884 111 103 4 0.0388349514563107 0.036036036036036
GO:BP GO:0060419 heart growth 0.0314295462688884 111 103 4 0.0388349514563107 0.036036036036036
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0314295462688884 3210 87 26 0.298850574712644 0.00809968847352025
GO:BP GO:0043001 Golgi to plasma membrane protein transport 0.0315231128282821 41 139 3 0.0215827338129496 0.0731707317073171
GO:BP GO:0035265 organ growth 0.0316598244454028 182 103 5 0.0485436893203883 0.0274725274725275
GO:BP GO:0030162 regulation of proteolysis 0.0319260652839978 752 37 6 0.162162162162162 0.00797872340425532
GO:BP GO:0071772 response to BMP 0.0322768575564898 171 34 3 0.0882352941176471 0.0175438596491228
GO:BP GO:0071773 cellular response to BMP stimulus 0.0322768575564898 171 34 3 0.0882352941176471 0.0175438596491228
GO:BP GO:0006954 inflammatory response 0.0322768575564898 794 8 3 0.375 0.00377833753148615
GO:BP GO:0001936 regulation of endothelial cell proliferation 0.0322768575564898 188 144 6 0.0416666666666667 0.0319148936170213
GO:BP GO:0048738 cardiac muscle tissue development 0.0331678672633277 224 122 6 0.0491803278688525 0.0267857142857143
GO:BP GO:0045444 fat cell differentiation 0.0334605878417197 229 26 3 0.115384615384615 0.0131004366812227
GO:BP GO:0060043 regulation of cardiac muscle cell proliferation 0.0334605878417197 57 103 3 0.029126213592233 0.0526315789473684
GO:BP GO:0043009 chordate embryonic development 0.0335267447036119 616 76 8 0.105263157894737 0.012987012987013
GO:BP GO:0061061 muscle structure development 0.0335267447036119 645 122 11 0.0901639344262295 0.0170542635658915
GO:BP GO:0050863 regulation of T cell activation 0.0335267447036119 337 18 3 0.166666666666667 0.00890207715133531
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.0336243425688119 338 18 3 0.166666666666667 0.00887573964497041
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 0.0347798043081347 369 127 8 0.062992125984252 0.021680216802168
GO:BP GO:0045861 negative regulation of proteolysis 0.0353624408756004 359 55 5 0.0909090909090909 0.0139275766016713
GO:BP GO:0003206 cardiac chamber morphogenesis 0.0359647818775359 120 51 3 0.0588235294117647 0.025
GO:BP GO:0018958 phenol-containing compound metabolic process 0.0363157503693005 110 56 3 0.0535714285714286 0.0272727272727273
GO:BP GO:0009056 catabolic process 0.0367292149379769 2744 12 6 0.5 0.0021865889212828
GO:BP GO:0009792 embryo development ending in birth or egg hatching 0.0371883942678367 635 76 8 0.105263157894737 0.0125984251968504
GO:BP GO:0061138 morphogenesis of a branching epithelium 0.0371883942678367 181 35 3 0.0857142857142857 0.0165745856353591
GO:BP GO:0048839 inner ear development 0.0372356662719177 193 65 4 0.0615384615384615 0.0207253886010363
GO:BP GO:0042472 inner ear morphogenesis 0.0372653083253394 97 65 3 0.0461538461538462 0.0309278350515464
GO:BP GO:1903708 positive regulation of hemopoiesis 0.0373761797106688 157 80 4 0.05 0.0254777070063694
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.0373761797106688 157 80 4 0.05 0.0254777070063694
GO:BP GO:0001704 formation of primary germ layer 0.0382250252079176 123 52 3 0.0576923076923077 0.024390243902439
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.0382250252079176 365 18 3 0.166666666666667 0.00821917808219178
GO:BP GO:2000027 regulation of animal organ morphogenesis 0.0382406076198052 184 35 3 0.0857142857142857 0.016304347826087
GO:BP GO:0097435 supramolecular fiber organization 0.0388135045103576 734 81 9 0.111111111111111 0.0122615803814714
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0399257981966557 982 22 5 0.227272727272727 0.00509164969450102
GO:BP GO:0060537 muscle tissue development 0.0399257981966557 399 122 8 0.0655737704918033 0.0200501253132832
GO:BP GO:0009100 glycoprotein metabolic process 0.0399257981966557 424 31 4 0.129032258064516 0.00943396226415094
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.0400324296103073 375 18 3 0.166666666666667 0.008
GO:BP GO:0032527 protein exit from endoplasmic reticulum 0.0400324296103073 48 137 3 0.0218978102189781 0.0625
GO:BP GO:0050821 protein stabilization 0.0400324296103073 193 67 4 0.0597014925373134 0.0207253886010363
GO:BP GO:0001935 endothelial cell proliferation 0.0403404752988454 204 144 6 0.0416666666666667 0.0294117647058824
GO:BP GO:0050900 leukocyte migration 0.0410935554800359 511 77 7 0.0909090909090909 0.0136986301369863
GO:BP GO:0035966 response to topologically incorrect protein 0.0410935554800359 205 144 6 0.0416666666666667 0.0292682926829268
GO:BP GO:0034103 regulation of tissue remodeling 0.0416983873530897 92 144 4 0.0277777777777778 0.0434782608695652
GO:BP GO:0001763 morphogenesis of a branching structure 0.0416983873530897 195 35 3 0.0857142857142857 0.0153846153846154
GO:BP GO:0050764 regulation of phagocytosis 0.0416983873530897 98 69 3 0.0434782608695652 0.0306122448979592
GO:BP GO:1901657 glycosyl compound metabolic process 0.0416983873530897 130 102 4 0.0392156862745098 0.0307692307692308
GO:BP GO:1901575 organic substance catabolic process 0.0416983873530897 2267 7 4 0.571428571428571 0.00176444640494045
GO:BP GO:0060038 cardiac muscle cell proliferation 0.0417526548964901 66 103 3 0.029126213592233 0.0454545454545455
GO:BP GO:0030336 negative regulation of cell migration 0.0417526548964901 353 85 6 0.0705882352941176 0.0169971671388102
GO:BP GO:0043010 camera-type eye development 0.04291158213603 331 65 5 0.0769230769230769 0.0151057401812689
GO:BP GO:0010975 regulation of neuron projection development 0.0431087620225451 451 16 3 0.1875 0.00665188470066519
GO:BP GO:0045620 negative regulation of lymphocyte differentiation 0.0431295764817338 57 123 3 0.024390243902439 0.0526315789473684
GO:BP GO:0034109 homotypic cell-cell adhesion 0.043216170305593 87 81 3 0.037037037037037 0.0344827586206897
GO:BP GO:0001819 positive regulation of cytokine production 0.0435719196191236 452 31 4 0.129032258064516 0.00884955752212389
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.0442363515297618 253 55 4 0.0727272727272727 0.0158102766798419
GO:BP GO:0002696 positive regulation of leukocyte activation 0.0448569097873616 412 18 3 0.166666666666667 0.00728155339805825
GO:BP GO:0048562 embryonic organ morphogenesis 0.0456910402454957 292 76 5 0.0657894736842105 0.0171232876712329
GO:BP GO:2000146 negative regulation of cell motility 0.0459120579906991 369 85 6 0.0705882352941176 0.016260162601626
GO:BP GO:0043583 ear development 0.0459120579906991 218 65 4 0.0615384615384615 0.018348623853211
GO:BP GO:0031175 neuron projection development 0.0463158771430008 1012 8 3 0.375 0.00296442687747036
GO:BP GO:0050867 positive regulation of cell activation 0.046720270428846 424 18 3 0.166666666666667 0.00707547169811321
GO:BP GO:0071158 positive regulation of cell cycle arrest 0.0469795880979639 88 85 3 0.0352941176470588 0.0340909090909091
GO:BP GO:0042110 T cell activation 0.0469795880979639 489 30 4 0.133333333333333 0.0081799591002045
GO:BP GO:0042471 ear morphogenesis 0.0471365287431575 116 65 3 0.0461538461538462 0.0258620689655172
GO:BP GO:0006790 sulfur compound metabolic process 0.0471365287431575 386 20 3 0.15 0.0077720207253886
GO:BP GO:0048699 generation of neurons 0.0471889054335079 1559 35 8 0.228571428571429 0.00513149454778704
GO:BP GO:0051271 negative regulation of cellular component movement 0.0477178095260756 377 85 6 0.0705882352941176 0.0159151193633952
GO:BP GO:0032101 regulation of response to external stimulus 0.0483756534317471 1051 8 3 0.375 0.00285442435775452
GO:BP GO:0010466 negative regulation of peptidase activity 0.0483756534317471 267 55 4 0.0727272727272727 0.0149812734082397
GO:BP GO:0016525 negative regulation of angiogenesis 0.0485356820468696 161 91 4 0.043956043956044 0.0248447204968944
GO:BP GO:0030217 T cell differentiation 0.0487203389103116 260 30 3 0.1 0.0115384615384615
GO:BP GO:0003205 cardiac chamber development 0.0494150006113425 161 143 5 0.034965034965035 0.031055900621118
GO:BP GO:0010628 positive regulation of gene expression 0.0497450273952915 1160 21 5 0.238095238095238 0.00431034482758621
GO:BP GO:2000181 negative regulation of blood vessel morphogenesis 0.0498672328177189 163 91 4 0.043956043956044 0.0245398773006135
GO:CC GO:0062023 collagen-containing extracellular matrix 9.33632428556486e-16 421 91 23 0.252747252747253 0.0546318289786223
GO:CC GO:0031012 extracellular matrix 1.15083456589079e-15 562 91 25 0.274725274725275 0.0444839857651246
GO:CC GO:0030312 external encapsulating structure 1.15083456589079e-15 563 91 25 0.274725274725275 0.044404973357016
GO:CC GO:0005576 extracellular region 7.47140411444116e-14 4567 105 64 0.60952380952381 0.0140135756514123
GO:CC GO:0005615 extracellular space 3.80596458916639e-13 3594 70 43 0.614285714285714 0.0119643850862549
GO:CC GO:0071944 cell periphery 8.9792956094514e-07 6169 16 16 1 0.00259361322742746
GO:CC GO:0005788 endoplasmic reticulum lumen 1.46421932796376e-06 307 111 13 0.117117117117117 0.0423452768729642
GO:CC GO:0005783 endoplasmic reticulum 5.60074788868511e-06 1982 137 36 0.262773722627737 0.0181634712411705
GO:CC GO:0070062 extracellular exosome 1.35165523516697e-05 2176 104 31 0.298076923076923 0.0142463235294118
GO:CC GO:0043230 extracellular organelle 2.61786761419576e-05 2263 104 31 0.298076923076923 0.0136986301369863
GO:CC GO:1903561 extracellular vesicle 2.61786761419576e-05 2261 104 31 0.298076923076923 0.0137107474568775
GO:CC GO:0031982 vesicle 3.24051493207722e-05 4055 107 45 0.420560747663551 0.0110974106041924
GO:CC GO:0043202 lysosomal lumen 7.79477195609084e-05 97 20 4 0.2 0.0412371134020619
GO:CC GO:0005796 Golgi lumen 7.85309733771465e-05 99 20 4 0.2 0.0404040404040404
GO:CC GO:0012505 endomembrane system 0.000517985909768999 4640 139 56 0.402877697841727 0.0120689655172414
GO:CC GO:0005775 vacuolar lumen 0.000517985909768999 174 7 3 0.428571428571429 0.0172413793103448
GO:CC GO:0098644 complex of collagen trimers 0.000517985909768999 21 52 3 0.0576923076923077 0.142857142857143
GO:CC GO:0009986 cell surface 0.000517985909768999 899 35 9 0.257142857142857 0.0100111234705228
GO:CC GO:0031258 lamellipodium membrane 0.000982635753400805 22 64 3 0.046875 0.136363636363636
GO:CC GO:0031253 cell projection membrane 0.00242602064876835 343 16 4 0.25 0.0116618075801749
GO:CC GO:0031256 leading edge membrane 0.0057119769756348 175 16 3 0.1875 0.0171428571428571
GO:CC GO:0005793 endoplasmic reticulum-Golgi intermediate compartment 0.00593268374623235 131 93 5 0.0537634408602151 0.0381679389312977
GO:CC GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 0.00593268374623235 74 93 4 0.043010752688172 0.0540540540540541
GO:CC GO:0005604 basement membrane 0.0100035753427466 97 144 5 0.0347222222222222 0.0515463917525773
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.0113863923423037 158 137 6 0.0437956204379562 0.0379746835443038
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.0142228939211828 166 137 6 0.0437956204379562 0.036144578313253
GO:CC GO:0140534 endoplasmic reticulum protein-containing complex 0.0165986314870909 128 128 5 0.0390625 0.0390625
GO:CC GO:0030670 phagocytic vesicle membrane 0.0202600330075712 76 67 3 0.0447761194029851 0.0394736842105263
GO:CC GO:0005795 Golgi stack 0.0202600330075712 149 74 4 0.0540540540540541 0.0268456375838926
GO:CC GO:0098590 plasma membrane region 0.0203392382947475 1240 16 5 0.3125 0.00403225806451613
GO:CC GO:0005789 endoplasmic reticulum membrane 0.0203772771387842 1117 137 17 0.124087591240876 0.0152193375111907
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.0204950056032503 1122 137 17 0.124087591240876 0.0151515151515152
GO:CC GO:0016324 apical plasma membrane 0.020814234381629 361 16 3 0.1875 0.00831024930747922
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.021654090119493 1139 137 17 0.124087591240876 0.0149253731343284
GO:CC GO:0005794 Golgi apparatus 0.021654090119493 1623 139 22 0.158273381294964 0.0135551447935921
GO:CC GO:0009897 external side of plasma membrane 0.0255068196639357 408 16 3 0.1875 0.00735294117647059
GO:CC GO:0070161 anchoring junction 0.0261063500191303 836 73 9 0.123287671232877 0.0107655502392345
GO:CC GO:0031252 cell leading edge 0.0271376842475029 422 16 3 0.1875 0.00710900473933649
GO:CC GO:0045177 apical part of cell 0.0280303038985598 431 16 3 0.1875 0.00696055684454756
GO:CC GO:0098552 side of membrane 0.0280303038985598 619 35 5 0.142857142857143 0.00807754442649435
GO:CC GO:0030660 Golgi-associated vesicle membrane 0.0302459095129622 52 139 3 0.0215827338129496 0.0576923076923077
GO:CC GO:0120025 plasma membrane bounded cell projection 0.0335718517291059 2229 16 6 0.375 0.00269179004037685
GO:CC GO:0042995 cell projection 0.0396059821815622 2330 16 6 0.375 0.00257510729613734
GO:CC GO:0031091 platelet alpha granule 0.0397307205864215 90 91 3 0.032967032967033 0.0333333333333333
GO:CC GO:0031984 organelle subcompartment 0.0417649983100004 1773 139 22 0.158273381294964 0.0124083474337281
GO:CC GO:0099512 supramolecular fiber 0.0495276392592358 993 10 3 0.3 0.00302114803625378
GO:CC GO:0045335 phagocytic vesicle 0.0495276392592358 137 67 3 0.0447761194029851 0.0218978102189781
GO:MF GO:0005201 extracellular matrix structural constituent 3.7438917157225e-11 171 91 14 0.153846153846154 0.0818713450292398
GO:MF GO:0005539 glycosaminoglycan binding 1.69101081289039e-07 238 109 13 0.119266055045872 0.0546218487394958
GO:MF GO:0005518 collagen binding 1.69101081289039e-07 70 127 9 0.0708661417322835 0.128571428571429
GO:MF GO:0005509 calcium ion binding 1.38976897865064e-05 721 131 20 0.152671755725191 0.0277392510402219
GO:MF GO:0030021 extracellular matrix structural constituent conferring compression resistance 2.45063868690002e-05 22 127 5 0.0393700787401575 0.227272727272727
GO:MF GO:0005198 structural molecule activity 8.28037078834024e-05 698 91 15 0.164835164835165 0.0214899713467049
GO:MF GO:0008201 heparin binding 8.87814869019016e-05 168 91 8 0.0879120879120879 0.0476190476190476
GO:MF GO:0004252 serine-type endopeptidase activity 0.00152560132076226 171 69 6 0.0869565217391304 0.0350877192982456
GO:MF GO:1901681 sulfur compound binding 0.00152560132076226 264 91 8 0.0879120879120879 0.0303030303030303
GO:MF GO:0008236 serine-type peptidase activity 0.00152560132076226 189 128 8 0.0625 0.0423280423280423
GO:MF GO:0017171 serine hydrolase activity 0.00163273356496657 193 128 8 0.0625 0.0414507772020725
GO:MF GO:0008233 peptidase activity 0.00334840280572291 646 69 10 0.144927536231884 0.0154798761609907
GO:MF GO:0003755 peptidyl-prolyl cis-trans isomerase activity 0.00338389894077381 44 111 4 0.036036036036036 0.0909090909090909
GO:MF GO:0016859 cis-trans isomerase activity 0.00411155369073252 47 111 4 0.036036036036036 0.0851063829787234
GO:MF GO:0004175 endopeptidase activity 0.00520373604659321 450 69 8 0.115942028985507 0.0177777777777778
GO:MF GO:0005178 integrin binding 0.0082397138680304 147 81 5 0.0617283950617284 0.0340136054421769
GO:MF GO:0008237 metallopeptidase activity 0.0082397138680304 188 36 4 0.111111111111111 0.0212765957446809
GO:MF GO:0061134 peptidase regulator activity 0.008491876756681 224 55 5 0.0909090909090909 0.0223214285714286
GO:MF GO:0004180 carboxypeptidase activity 0.0225709382883865 43 98 3 0.0306122448979592 0.0697674418604651
GO:MF GO:0008238 exopeptidase activity 0.0230228917091663 95 98 4 0.0408163265306122 0.0421052631578947
GO:MF GO:0050840 extracellular matrix binding 0.0306597404360102 56 88 3 0.0340909090909091 0.0535714285714286
GO:MF GO:0044877 protein-containing complex binding 0.0421021493377801 1287 16 5 0.3125 0.00388500388500389
GO:MF GO:0097367 carbohydrate derivative binding 0.0442736527921845 2285 23 8 0.347826086956522 0.00350109409190372
GO:MF GO:0005102 signaling receptor binding 0.045052252800517 1672 81 15 0.185185185185185 0.00897129186602871
GO:MF GO:0004866 endopeptidase inhibitor activity 0.045052252800517 176 37 3 0.0810810810810811 0.0170454545454545
GO:MF GO:0030414 peptidase inhibitor activity 0.0460985097676475 182 37 3 0.0810810810810811 0.0164835164835165
GO:MF GO:0061135 endopeptidase regulator activity 0.0460985097676475 188 37 3 0.0810810810810811 0.0159574468085106
GO:MF GO:0016787 hydrolase activity 0.0460985097676475 2615 69 18 0.260869565217391 0.00688336520076482
REAC REAC:R-HSA-1474244 Extracellular matrix organization 1.72636933051304e-06 298 23 9 0.391304347826087 0.0302013422818792
REAC REAC:R-HSA-1592389 Activation of Matrix Metalloproteinases 0.000883418146179094 33 12 3 0.25 0.0909090909090909
REAC REAC:R-HSA-1442490 Collagen degradation 0.001432828820818 64 52 5 0.0961538461538462 0.078125
REAC REAC:R-HSA-3560782 Diseases associated with glycosaminoglycan metabolism 0.00397975552598509 41 20 3 0.15 0.0731707317073171
REAC REAC:R-HSA-3781865 Diseases of glycosylation 0.00448014692152485 140 20 4 0.2 0.0285714285714286
REAC REAC:R-HSA-1650814 Collagen biosynthesis and modifying enzymes 0.00782856701843024 67 52 4 0.0769230769230769 0.0597014925373134
REAC REAC:R-HSA-3000178 ECM proteoglycans 0.00782856701843024 75 81 5 0.0617283950617284 0.0666666666666667
REAC REAC:R-HSA-1474228 Degradation of the extracellular matrix 0.00981442933707122 140 12 3 0.25 0.0214285714285714
REAC REAC:R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 0.00981442933707122 124 14 3 0.214285714285714 0.0241935483870968
REAC REAC:R-HSA-2022857 Keratan sulfate degradation 0.00981442933707122 13 138 3 0.0217391304347826 0.230769230769231
REAC REAC:R-HSA-5668914 Diseases of metabolism 0.0118049530239883 241 20 4 0.2 0.016597510373444
REAC REAC:R-HSA-1474290 Collagen formation 0.0118049530239883 89 52 4 0.0769230769230769 0.0449438202247191
REAC REAC:R-HSA-2129379 Molecules associated with elastic fibres 0.0163646255384469 37 66 3 0.0454545454545455 0.0810810810810811
REAC REAC:R-HSA-1630316 Glycosaminoglycan metabolism 0.0163646255384469 123 20 3 0.15 0.024390243902439
REAC REAC:R-HSA-1566948 Elastic fibre formation 0.025101504438047 44 66 3 0.0454545454545455 0.0681818181818182
REAC REAC:R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 0.0286331013827937 60 52 3 0.0576923076923077 0.05
TF TF:M07040 Factor: GKLF; motif: NNRRGRRNGNSNNN 0.000842996860763176 12705 124 106 0.854838709677419 0.00834317197953562
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.00653271995452809 16384 108 105 0.972222222222222 0.00640869140625
TF TF:M09910_1 Factor: ER-beta; motif: RGGTCASCNTGMCCY; match class: 1 0.00653271995452809 4079 101 41 0.405940594059406 0.0100514832066683
TF TF:M09826 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC 0.00653271995452809 11467 58 50 0.862068965517241 0.00436033836225691
TF TF:M07322_1 Factor: HSF4; motif: CTGCMRN; match class: 1 0.0141618713862217 11797 97 78 0.804123711340206 0.00661185047045859
TF TF:M01303 Factor: SP1; motif: GGGGYGGGGNS 0.0141618713862217 7898 72 47 0.652777777777778 0.00595087363889592
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.020664785219104 8180 131 78 0.595419847328244 0.00953545232273839
TF TF:M10107 Factor: DB1; motif: GGRRRRGRRGGAGGGGGNGRRR 0.0225763375829937 5822 39 24 0.615384615384615 0.0041222947440742
TF TF:M01593_1 Factor: Zfx; motif: SNSCAGGCCKCGSCSS; match class: 1 0.0225763375829937 970 136 19 0.139705882352941 0.0195876288659794
TF TF:M08952 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN 0.0225763375829937 7763 97 58 0.597938144329897 0.00747133840010305
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.0225763375829937 14096 108 95 0.87962962962963 0.00673950056753689
TF TF:M12313 Factor: ZNF460; motif: NNACNCCCCCCNN 0.0322807079187365 5825 122 56 0.459016393442623 0.0096137339055794
TF TF:M07289_1 Factor: GKLF; motif: NNNRGGNGNGGSN; match class: 1 0.0322807079187365 10555 53 42 0.792452830188679 0.0039791567977262
TF TF:M06484 Factor: ZNF683; motif: TTCCYAAATGC 0.0322807079187365 15 122 3 0.0245901639344262 0.2
TF TF:M09984 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG 0.0322807079187365 9544 57 42 0.736842105263158 0.00440067057837385
TF TF:M04950_1 Factor: Egr-1; motif: NGCGTGCGY; match class: 1 0.0322807079187365 5551 100 46 0.46 0.00828679517204107
TF TF:M07289 Factor: GKLF; motif: NNNRGGNGNGGSN 0.0322807079187365 14646 55 52 0.945454545454545 0.00355045746278847
TF TF:M01733 Factor: MZF-1; motif: TGGGGAR 0.0322807079187365 11391 118 88 0.745762711864407 0.0077253972434378
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.0322807079187365 12302 134 104 0.776119402985075 0.00845390993334417
TF TF:M07065 Factor: STAT3; motif: TTCYGGGAAN 0.0322807079187365 4948 58 28 0.482758620689655 0.00565885206143896
TF TF:M09734 Factor: ZNF692; motif: SYNGGSCCCASCCNC 0.0322807079187365 11678 63 52 0.825396825396825 0.00445281726323001
TF TF:M00333 Factor: ZF5; motif: NRNGNGCGCGCWN 0.0322807079187365 15072 145 129 0.889655172413793 0.00855891719745223
TF TF:M00033 Factor: p300; motif: NNNGGGAGTNNNNS 0.0322807079187365 8577 67 45 0.671641791044776 0.00524658971668416
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0323991862077403 13611 145 120 0.827586206896552 0.00881639850121226
TF TF:M03796 Factor: MafA; motif: GGTCAGCAGH 0.0340396872918844 4720 88 37 0.420454545454545 0.00783898305084746
TF TF:M00033_1 Factor: p300; motif: NNNGGGAGTNNNNS; match class: 1 0.0340396872918844 2588 69 21 0.304347826086957 0.00811437403400309
TF TF:M09738 Factor: ZNF511; motif: GGRRGRGGCWGNG 0.0360824843961332 10865 60 47 0.783333333333333 0.00432581684307409
TF TF:M07040_1 Factor: GKLF; motif: NNRRGRRNGNSNNN; match class: 1 0.0360824843961332 8156 143 81 0.566433566433566 0.00993133889161354
TF TF:M04953 Factor: Sp1; motif: GGNDGGRGGCGGGG 0.039943922068153 8688 130 78 0.6 0.00897790055248619
TF TF:M00223 Factor: STAT; motif: TTCCCGKAA 0.0403609513456031 3501 7 6 0.857142857142857 0.00171379605826907
TF TF:M11529 Factor: E2F-2; motif: GCGCGCGCNCS 0.0403638375124923 16263 106 100 0.943396226415094 0.00614892701223636
TF TF:M01219_1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 0.0403638375124923 2937 131 35 0.267175572519084 0.0119169220292816
TF TF:M09894 Factor: E2F-4; motif: SNGGGCGGGAANN 0.0403638375124923 16194 139 129 0.928057553956835 0.00796591330122268
TF TF:M01177_1 Factor: SREBP-2; motif: NNGYCACNNSMN; match class: 1 0.0403638375124923 2842 104 29 0.278846153846154 0.0102040816326531
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.0403638375124923 10055 138 91 0.659420289855073 0.00905022376926902
TF TF:M04466 Factor: HNF4A; motif: GGGGTCAAAGGTCA 0.0403638375124923 1278 21 7 0.333333333333333 0.0054773082942097
TF TF:M02089 Factor: E2F-3; motif: GGCGGGN 0.0403638375124923 13173 108 89 0.824074074074074 0.00675624383208077
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0403638375124923 10419 137 93 0.678832116788321 0.00892600057587101
TF TF:M09790_1 Factor: TWIST1; motif: NNNCCAGATGTNN; match class: 1 0.0403638375124923 265 67 6 0.0895522388059701 0.0226415094339623
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.0403638375124923 10853 58 45 0.775862068965517 0.00414631899014097
TF TF:M07461 Factor: KLF; motif: GGGNGGGG 0.0403638375124923 8757 14 13 0.928571428571429 0.00148452666438278
TF TF:M07261_1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 0.0403638375124923 4062 48 21 0.4375 0.0051698670605613
TF TF:M00470 Factor: AP-2gamma; motif: GCCYNNGGS 0.0403638375124923 9422 30 24 0.8 0.00254722988749735
TF TF:M01104_1 Factor: MOVO-B; motif: GNGGGGG; match class: 1 0.0403638375124923 5626 57 29 0.508771929824561 0.00515463917525773
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.0403638375124923 3919 16 10 0.625 0.0025516713447308
TF TF:M08819 Factor: LKLF; motif: CNCCACCCS 0.0403638375124923 5591 42 23 0.547619047619048 0.00411375424789841
TF TF:M11365 Factor: MafA; motif: NYGCTGASTCAGCRN 0.0403638375124923 506 121 11 0.0909090909090909 0.0217391304347826
TF TF:M11818 Factor: T3R-beta; motif: NTGACCTYRNYRAGGTCAN 0.0403638375124923 11824 16 16 1 0.0013531799729364
TF TF:M00444_1 Factor: VDR; motif: GGGKNARNRRGGWSA; match class: 1 0.0403638375124923 4534 55 25 0.454545454545455 0.00551389501543891
TF TF:M00807 Factor: Egr; motif: GTGGGSGCRRS 0.0403983004347764 4343 95 36 0.378947368421053 0.00828920101312457
TF TF:M09723 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS 0.0403983004347764 10156 134 89 0.664179104477612 0.00876329263489563
TF TF:M11385 Factor: ESE-1; motif: NTGTGCGGATGCN 0.0405900180870521 12232 118 91 0.771186440677966 0.00743950294310007
TF TF:M00446_1 Factor: Spz1; motif: DNNGGRGGGWWNNNN; match class: 1 0.0405900180870521 2858 76 23 0.302631578947368 0.00804758572428271
TF TF:M07350_1 Factor: BMAL1; motif: AGCCAYKKGA; match class: 1 0.0405959129500783 84 141 5 0.0354609929078014 0.0595238095238095
TF TF:M10079 Factor: STAT1; motif: NCCNTTTCCNGGAAANCNC 0.0408506447980583 2284 7 5 0.714285714285714 0.00218914185639229
TF TF:M10139 Factor: ZNF320; motif: GKGGGNCCMGGGGGCCWRTG 0.0411271901069184 688 139 14 0.100719424460432 0.0203488372093023
TF TF:M09636 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG 0.0437625583515733 16244 145 134 0.924137931034483 0.00824919970450628
TF TF:M10529 Factor: Sp1; motif: RGGGMGGRGSNGGGG 0.0468398552729285 6891 108 55 0.509259259259259 0.00798142504716297
TF TF:M12227 Factor: ZIC4; motif: NNCCNCCCRYNGYGN 0.0468398552729285 11063 143 100 0.699300699300699 0.00903913947392208
TF TF:M09977 Factor: Lyl-1; motif: NCAKCTGYTNYCNN 0.0468398552729285 13787 90 77 0.855555555555556 0.0055849713498223
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.0468398552729285 14873 145 126 0.868965517241379 0.00847172729106434
TF TF:M01306 Factor: ZABC1; motif: ATTCCNAC 0.0472272720727164 9221 119 74 0.621848739495798 0.00802515996095868
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0472272720727164 10281 137 91 0.664233576642336 0.00885127905845735
TF TF:M09734_1 Factor: ZNF692; motif: SYNGGSCCCASCCNC; match class: 1 0.0472272720727164 6255 100 48 0.48 0.00767386091127098
TF TF:M06387 Factor: ZSCAN2; motif: NGGGWAAAACGC 0.0472272720727164 101 128 5 0.0390625 0.0495049504950495
TF TF:M04595 Factor: SALL2; motif: GGGTGGG 0.0472272720727164 13013 35 32 0.914285714285714 0.00245907938215631
TF TF:M07261 Factor: LKLF; motif: GGGGTGGKSN 0.0472272720727164 9774 44 33 0.75 0.00337630448127686
TF TF:M08819_1 Factor: LKLF; motif: CNCCACCCS; match class: 1 0.0472272720727164 1532 74 15 0.202702702702703 0.0097911227154047

pS07 transcription factor target enrichment of top program genes

TF enrichment of pS07
TFs corrosponding to activation of pS07. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.