pEpi01 program activity among Epithelial cells

Activation of pEpi01
pEpi01 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi01 by different cell subtypes
pEpi01 gene program activation among cells of different subtypes (Epithelial cells).

pEpi01 top program genes

Top genes of pEpi01 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi01 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi01
pEpi01 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0051607 defense response to virus 2.07248039618001e-16 267 57 18 0.315789473684211 0.0674157303370786
GO:BP GO:0140546 defense response to symbiont 2.07248039618001e-16 267 57 18 0.315789473684211 0.0674157303370786
GO:BP GO:0009615 response to virus 3.50486335366842e-14 364 57 18 0.315789473684211 0.0494505494505494
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 1.77695043970039e-13 2255 101 46 0.455445544554455 0.0203991130820399
GO:BP GO:0019058 viral life cycle 2.49681191193766e-13 353 140 24 0.171428571428571 0.0679886685552408
GO:BP GO:0009607 response to biotic stimulus 2.49992587442564e-12 1626 57 28 0.491228070175439 0.017220172201722
GO:BP GO:0098542 defense response to other organism 2.49992587442564e-12 1218 57 25 0.43859649122807 0.0205254515599343
GO:BP GO:0071357 cellular response to type I interferon 2.85695711185403e-12 96 57 11 0.192982456140351 0.114583333333333
GO:BP GO:0060337 type I interferon signaling pathway 2.85695711185403e-12 95 57 11 0.192982456140351 0.115789473684211
GO:BP GO:0045087 innate immune response 2.85695711185403e-12 998 57 23 0.403508771929825 0.0230460921843687
GO:BP GO:0034340 response to type I interferon 4.62651883580125e-12 101 57 11 0.192982456140351 0.108910891089109
GO:BP GO:0043207 response to external biotic stimulus 7.51938333525425e-12 1594 57 27 0.473684210526316 0.0169385194479297
GO:BP GO:0051707 response to other organism 7.51938333525425e-12 1592 57 27 0.473684210526316 0.0169597989949749
GO:BP GO:0044403 biological process involved in symbiotic interaction 1.7249975241399e-11 1001 129 33 0.255813953488372 0.032967032967033
GO:BP GO:0006952 defense response 1.8424360138857e-11 1818 57 28 0.491228070175439 0.0154015401540154
GO:BP GO:0002252 immune effector process 5.69493957563724e-11 1309 57 24 0.421052631578947 0.0183346065699007
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 7.12378383337357e-11 203 140 17 0.121428571428571 0.083743842364532
GO:BP GO:0006950 response to stress 7.87540605897807e-11 4170 57 39 0.684210526315789 0.00935251798561151
GO:BP GO:0016032 viral process 8.53792837259469e-11 942 98 27 0.275510204081633 0.0286624203821656
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 1.67751120435469e-10 251 140 18 0.128571428571429 0.0717131474103586
GO:BP GO:0009605 response to external stimulus 1.7612492973198e-10 2944 57 33 0.578947368421053 0.0112092391304348
GO:BP GO:1903900 regulation of viral life cycle 1.95332665217504e-10 153 56 11 0.196428571428571 0.0718954248366013
GO:BP GO:0010033 response to organic substance 2.49599306677508e-10 3412 57 35 0.614035087719298 0.0102579132473623
GO:BP GO:0050792 regulation of viral process 2.81298792553253e-10 192 140 16 0.114285714285714 0.0833333333333333
GO:BP GO:0045071 negative regulation of viral genome replication 3.64121794891354e-10 54 52 8 0.153846153846154 0.148148148148148
GO:BP GO:0048525 negative regulation of viral process 6.86780483937462e-10 94 33 8 0.242424242424242 0.0851063829787234
GO:BP GO:0034097 response to cytokine 7.45666867501237e-10 1226 57 22 0.385964912280702 0.0179445350734095
GO:BP GO:0071345 cellular response to cytokine stimulus 1.38365874425968e-09 1132 57 21 0.368421052631579 0.0185512367491166
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 1.39657236640443e-09 291 140 18 0.128571428571429 0.0618556701030928
GO:BP GO:0002376 immune system process 2.60773540885803e-09 3278 57 33 0.578947368421053 0.0100671140939597
GO:BP GO:0006955 immune response 3.2889361619435e-09 2311 57 28 0.491228070175439 0.0121159671138035
GO:BP GO:0070887 cellular response to chemical stimulus 6.4122334573858e-09 3393 57 33 0.578947368421053 0.00972590627763042
GO:BP GO:0045069 regulation of viral genome replication 1.08311725003258e-08 84 52 8 0.153846153846154 0.0952380952380952
GO:BP GO:0019079 viral genome replication 1.17214429488976e-08 131 125 12 0.096 0.0916030534351145
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 1.82856128750603e-08 185 140 14 0.1 0.0756756756756757
GO:BP GO:0071310 cellular response to organic substance 3.82255229626804e-08 2776 57 29 0.508771929824561 0.0104466858789625
GO:BP GO:0042221 response to chemical 1.18468048615327e-07 4781 57 37 0.649122807017544 0.00773896674335913
GO:BP GO:0051701 biological process involved in interaction with host 1.74435298830013e-07 221 140 14 0.1 0.0633484162895928
GO:BP GO:0019221 cytokine-mediated signaling pathway 2.15869129906155e-07 810 57 16 0.280701754385965 0.0197530864197531
GO:BP GO:0016050 vesicle organization 3.14814383324338e-07 341 131 16 0.122137404580153 0.0469208211143695
GO:BP GO:0052126 movement in host environment 1.15363377979937e-06 177 140 12 0.0857142857142857 0.0677966101694915
GO:BP GO:0002831 regulation of response to biotic stimulus 4.13697244078949e-06 415 56 11 0.196428571428571 0.0265060240963855
GO:BP GO:0071346 cellular response to interferon-gamma 4.58309369423105e-06 175 55 8 0.145454545454545 0.0457142857142857
GO:BP GO:0007166 cell surface receptor signaling pathway 4.76367307664032e-06 3210 57 28 0.491228070175439 0.00872274143302181
GO:BP GO:0062207 regulation of pattern recognition receptor signaling pathway 4.7868926640498e-06 108 125 9 0.072 0.0833333333333333
GO:BP GO:0048519 negative regulation of biological process 5.45520197487018e-06 5757 55 37 0.672727272727273 0.00642695848532222
GO:BP GO:0007032 endosome organization 7.86532189892328e-06 80 129 8 0.062015503875969 0.1
GO:BP GO:0002221 pattern recognition receptor signaling pathway 8.64683076022755e-06 213 50 8 0.16 0.0375586854460094
GO:BP GO:0034341 response to interferon-gamma 9.65362254992692e-06 196 55 8 0.145454545454545 0.0408163265306122
GO:BP GO:0023052 signaling 1.05543409792746e-05 6810 57 41 0.719298245614035 0.00602055800293686
GO:BP GO:0044409 entry into host 1.11129498303966e-05 154 71 8 0.112676056338028 0.051948051948052
GO:BP GO:0060333 interferon-gamma-mediated signaling pathway 1.33470325251155e-05 88 52 6 0.115384615384615 0.0681818181818182
GO:BP GO:0007165 signal transduction 1.65424658420723e-05 6309 57 39 0.684210526315789 0.00618164526866381
GO:BP GO:1902531 regulation of intracellular signal transduction 1.69090371559696e-05 1842 144 36 0.25 0.0195439739413681
GO:BP GO:0048518 positive regulation of biological process 2.1765511199851e-05 6363 115 67 0.582608695652174 0.0105296243910105
GO:BP GO:0051716 cellular response to stimulus 4.05866702263802e-05 7781 57 43 0.754385964912281 0.0055262819688986
GO:BP GO:0007154 cell communication 4.15614370074894e-05 6829 57 40 0.701754385964912 0.00585737296822375
GO:BP GO:0035455 response to interferon-alpha 4.74453077221823e-05 23 57 4 0.0701754385964912 0.173913043478261
GO:BP GO:0032103 positive regulation of response to external stimulus 7.17260685622074e-05 513 133 16 0.120300751879699 0.0311890838206628
GO:BP GO:0046718 viral entry into host cell 8.04139883421907e-05 141 71 7 0.0985915492957746 0.049645390070922
GO:BP GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 0.00010289240098437 73 50 5 0.1 0.0684931506849315
GO:BP GO:0031349 positive regulation of defense response 0.000108835279887403 362 109 12 0.110091743119266 0.0331491712707182
GO:BP GO:0060700 regulation of ribonuclease activity 0.000108835279887403 9 52 3 0.0576923076923077 0.333333333333333
GO:BP GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 0.000114183529056176 33 50 4 0.08 0.121212121212121
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.000121874302267491 1037 144 24 0.166666666666667 0.0231436837029894
GO:BP GO:0039530 MDA-5 signaling pathway 0.00013094276954567 10 50 3 0.06 0.3
GO:BP GO:0098780 response to mitochondrial depolarisation 0.000182274283714614 20 27 3 0.111111111111111 0.15
GO:BP GO:0048522 positive regulation of cellular process 0.000233745652945491 5757 115 60 0.521739130434783 0.0104220948410631
GO:BP GO:0045088 regulation of innate immune response 0.000244052594251718 309 56 8 0.142857142857143 0.0258899676375405
GO:BP GO:0031347 regulation of defense response 0.000247133317879002 704 109 16 0.146788990825688 0.0227272727272727
GO:BP GO:0044248 cellular catabolic process 0.000262589844186981 2347 145 39 0.268965517241379 0.0166169578184917
GO:BP GO:0048584 positive regulation of response to stimulus 0.000295892863362201 2344 115 33 0.28695652173913 0.0140784982935154
GO:BP GO:0050896 response to stimulus 0.000306679529036914 9407 57 46 0.807017543859649 0.00488997555012225
GO:BP GO:0010646 regulation of cell communication 0.000315342037926381 3543 115 43 0.373913043478261 0.0121366073948631
GO:BP GO:0035457 cellular response to interferon-alpha 0.000344951866718133 13 54 3 0.0555555555555556 0.230769230769231
GO:BP GO:1902532 negative regulation of intracellular signal transduction 0.000346298753317268 549 143 16 0.111888111888112 0.029143897996357
GO:BP GO:0140112 extracellular vesicle biogenesis 0.000357913772069166 22 106 4 0.0377358490566038 0.181818181818182
GO:BP GO:0032101 regulation of response to external stimulus 0.000374085207943032 1051 133 22 0.165413533834586 0.0209324452901998
GO:BP GO:0023051 regulation of signaling 0.000382814251230043 3578 115 43 0.373913043478261 0.0120178870877585
GO:BP GO:0080134 regulation of response to stress 0.000408952047071628 1443 114 24 0.210526315789474 0.0166320166320166
GO:BP GO:0002833 positive regulation of response to biotic stimulus 0.000421262864856097 250 125 10 0.08 0.04
GO:BP GO:0035556 intracellular signal transduction 0.000425791242872645 2772 114 36 0.315789473684211 0.012987012987013
GO:BP GO:0045216 cell-cell junction organization 0.000433910433285618 216 63 7 0.111111111111111 0.0324074074074074
GO:BP GO:0008219 cell death 0.000632828189836466 2292 67 22 0.328358208955224 0.00959860383944154
GO:BP GO:0050789 regulation of biological process 0.000650233159237768 12091 57 52 0.912280701754386 0.00430071954346208
GO:BP GO:0012501 programmed cell death 0.000707096518905734 2143 114 30 0.263157894736842 0.0139990667288847
GO:BP GO:0048523 negative regulation of cellular process 0.000787768375019456 5139 51 29 0.568627450980392 0.00564312122981125
GO:BP GO:0032481 positive regulation of type I interferon production 0.000794125798477339 80 125 6 0.048 0.075
GO:BP GO:0034329 cell junction assembly 0.000802368830467187 438 63 9 0.142857142857143 0.0205479452054795
GO:BP GO:0009967 positive regulation of signal transduction 0.000810241017112391 1598 144 29 0.201388888888889 0.0181476846057572
GO:BP GO:0048583 regulation of response to stimulus 0.000811160676222798 4278 51 26 0.509803921568627 0.00607760635811127
GO:BP GO:0006915 apoptotic process 0.000822666630672182 1990 67 20 0.298507462686567 0.0100502512562814
GO:BP GO:0010647 positive regulation of cell communication 0.000822666630672182 1777 144 31 0.215277777777778 0.0174451322453573
GO:BP GO:0039531 regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway 0.000822666630672182 24 125 4 0.032 0.166666666666667
GO:BP GO:0009893 positive regulation of metabolic process 0.000830972372640454 3783 145 52 0.358620689655172 0.013745704467354
GO:BP GO:0023056 positive regulation of signaling 0.000849612360500731 1782 144 31 0.215277777777778 0.0173961840628507
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 0.000879437195228936 243 114 9 0.0789473684210526 0.037037037037037
GO:BP GO:0065009 regulation of molecular function 0.000971140521517941 3221 144 46 0.319444444444444 0.0142812791058677
GO:BP GO:0006508 proteolysis 0.000987868479146319 1836 103 25 0.242718446601942 0.0136165577342048
GO:BP GO:0009966 regulation of signal transduction 0.00110875922731289 3165 114 38 0.333333333333333 0.0120063191153239
GO:BP GO:0045921 positive regulation of exocytosis 0.00118191674887325 90 122 6 0.0491803278688525 0.0666666666666667
GO:BP GO:0030163 protein catabolic process 0.00118424079433563 974 103 17 0.16504854368932 0.0174537987679671
GO:BP GO:0032069 regulation of nuclease activity 0.00118424079433563 22 52 3 0.0576923076923077 0.136363636363636
GO:BP GO:0034330 cell junction organization 0.00122734632541071 722 63 11 0.174603174603175 0.0152354570637119
GO:BP GO:0010256 endomembrane system organization 0.00122734632541071 484 145 14 0.096551724137931 0.0289256198347107
GO:BP GO:0050794 regulation of cellular process 0.00124647591474177 11473 57 50 0.87719298245614 0.00435805804933322
GO:BP GO:0010648 negative regulation of cell communication 0.00126176656813937 1468 114 23 0.201754385964912 0.0156675749318801
GO:BP GO:0023057 negative regulation of signaling 0.00129061936064608 1471 114 23 0.201754385964912 0.0156356220258328
GO:BP GO:1904903 ESCRT III complex disassembly 0.00136918563122212 10 129 3 0.0232558139534884 0.3
GO:BP GO:1904896 ESCRT complex disassembly 0.00136918563122212 10 129 3 0.0232558139534884 0.3
GO:BP GO:0008104 protein localization 0.00147801642597178 2770 145 41 0.282758620689655 0.0148014440433213
GO:BP GO:0031532 actin cytoskeleton reorganization 0.00147801642597178 106 34 4 0.117647058823529 0.0377358490566038
GO:BP GO:0098586 cellular response to virus 0.00150215881024079 72 50 4 0.08 0.0555555555555556
GO:BP GO:0015031 protein transport 0.00151564013289007 1929 145 32 0.220689655172414 0.0165889061689995
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0015193014367248 3483 114 40 0.350877192982456 0.0114843525696239
GO:BP GO:0002224 toll-like receptor signaling pathway 0.0015193014367248 161 45 5 0.111111111111111 0.031055900621118
GO:BP GO:1903543 positive regulation of exosomal secretion 0.00152380279282314 15 88 3 0.0340909090909091 0.2
GO:BP GO:0045089 positive regulation of innate immune response 0.00165527733807824 216 56 6 0.107142857142857 0.0277777777777778
GO:BP GO:0045184 establishment of protein localization 0.00168587619607942 2035 145 33 0.227586206896552 0.0162162162162162
GO:BP GO:0036258 multivesicular body assembly 0.00179142966501053 30 129 4 0.0310077519379845 0.133333333333333
GO:BP GO:1903541 regulation of exosomal secretion 0.00180708379044131 16 88 3 0.0340909090909091 0.1875
GO:BP GO:0016192 vesicle-mediated transport 0.00186470558474005 2180 131 32 0.244274809160305 0.0146788990825688
GO:BP GO:0036257 multivesicular body organization 0.00199563615941544 31 129 4 0.0310077519379845 0.129032258064516
GO:BP GO:0015833 peptide transport 0.00209902232497073 1971 145 32 0.220689655172414 0.0162354134956875
GO:BP GO:0048524 positive regulation of viral process 0.00217825227888236 91 140 6 0.0428571428571429 0.0659340659340659
GO:BP GO:0070266 necroptotic process 0.00240392085528065 46 91 4 0.043956043956044 0.0869565217391304
GO:BP GO:0009612 response to mechanical stimulus 0.00261286866254244 218 61 6 0.0983606557377049 0.0275229357798165
GO:BP GO:0019076 viral release from host cell 0.00271647777135582 34 129 4 0.0310077519379845 0.117647058823529
GO:BP GO:0035890 exit from host 0.00271647777135582 34 129 4 0.0310077519379845 0.117647058823529
GO:BP GO:0035891 exit from host cell 0.00271647777135582 34 129 4 0.0310077519379845 0.117647058823529
GO:BP GO:0042886 amide transport 0.00279966663488536 2007 145 32 0.220689655172414 0.0159441953163926
GO:BP GO:1990182 exosomal secretion 0.00281492460790311 19 88 3 0.0340909090909091 0.157894736842105
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.002823892891252 3274 145 45 0.310344827586207 0.0137446548564447
GO:BP GO:0001894 tissue homeostasis 0.00290769864307786 270 51 6 0.117647058823529 0.0222222222222222
GO:BP GO:0032728 positive regulation of interferon-beta production 0.00290999312018498 36 125 4 0.032 0.111111111111111
GO:BP GO:0009968 negative regulation of signal transduction 0.00292336031193756 1364 114 21 0.184210526315789 0.0153958944281525
GO:BP GO:0043068 positive regulation of programmed cell death 0.00293499648204181 621 111 13 0.117117117117117 0.0209339774557166
GO:BP GO:0034121 regulation of toll-like receptor signaling pathway 0.0030196278200493 79 109 5 0.0458715596330275 0.0632911392405063
GO:BP GO:0097734 extracellular exosome biogenesis 0.00313505412968573 20 88 3 0.0340909090909091 0.15
GO:BP GO:1901575 organic substance catabolic process 0.003177725023641 2267 125 31 0.248 0.0136744596382885
GO:BP GO:1903532 positive regulation of secretion by cell 0.00344655005412676 285 122 9 0.0737704918032787 0.0315789473684211
GO:BP GO:0001817 regulation of cytokine production 0.00346669964663017 806 55 10 0.181818181818182 0.0124069478908189
GO:BP GO:0009057 macromolecule catabolic process 0.00352031684150285 1468 116 22 0.189655172413793 0.0149863760217984
GO:BP GO:0033036 macromolecule localization 0.00357872135297261 3218 145 44 0.303448275862069 0.0136730888750777
GO:BP GO:0016567 protein ubiquitination 0.00359010256558479 892 114 16 0.140350877192982 0.0179372197309417
GO:BP GO:0045601 regulation of endothelial cell differentiation 0.00376937258119319 50 98 4 0.0408163265306122 0.08
GO:BP GO:0097300 programmed necrotic cell death 0.00377509734628476 54 91 4 0.043956043956044 0.0740740740740741
GO:BP GO:0065007 biological regulation 0.00393960972080116 12809 57 52 0.912280701754386 0.00405964556171442
GO:BP GO:0032506 cytokinetic process 0.00393960972080116 39 129 4 0.0310077519379845 0.102564102564103
GO:BP GO:0044257 cellular protein catabolic process 0.00393960972080116 813 101 14 0.138613861386139 0.017220172201722
GO:BP GO:1903530 regulation of secretion by cell 0.00393960972080116 588 122 13 0.10655737704918 0.022108843537415
GO:BP GO:0070830 bicellular tight junction assembly 0.00402418337701149 80 63 4 0.0634920634920635 0.05
GO:BP GO:0009056 catabolic process 0.00406249002987883 2744 145 39 0.268965517241379 0.0142128279883382
GO:BP GO:0046903 secretion 0.00406249002987883 1501 131 24 0.183206106870229 0.0159893404397069
GO:BP GO:0007043 cell-cell junction assembly 0.00408426729171115 151 63 5 0.0793650793650794 0.033112582781457
GO:BP GO:0000422 autophagy of mitochondrion 0.0041763053013722 75 27 3 0.111111111111111 0.04
GO:BP GO:0061726 mitochondrion disassembly 0.0041763053013722 75 27 3 0.111111111111111 0.04
GO:BP GO:0120192 tight junction assembly 0.00423945016934606 82 63 4 0.0634920634920635 0.0487804878048781
GO:BP GO:0140352 export from cell 0.00435871183106622 1418 131 23 0.175572519083969 0.0162200282087447
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.00435871183106622 3083 144 42 0.291666666666667 0.0136230943885825
GO:BP GO:0001816 cytokine production 0.00435871183106622 844 55 10 0.181818181818182 0.0118483412322275
GO:BP GO:1901565 organonitrogen compound catabolic process 0.0045652977542584 1358 103 19 0.184466019417476 0.0139911634756996
GO:BP GO:0062208 positive regulation of pattern recognition receptor signaling pathway 0.00467140299482279 43 125 4 0.032 0.0930232558139535
GO:BP GO:0061952 midbody abscission 0.00478411837676394 17 129 3 0.0232558139534884 0.176470588235294
GO:BP GO:0061028 establishment of endothelial barrier 0.00492249925509728 50 109 4 0.036697247706422 0.08
GO:BP GO:0046578 regulation of Ras protein signal transduction 0.00498923980568541 199 28 4 0.142857142857143 0.0201005025125628
GO:BP GO:0120193 tight junction organization 0.00502133840258509 87 63 4 0.0634920634920635 0.0459770114942529
GO:BP GO:0007155 cell adhesion 0.00503875336267831 1492 59 14 0.23728813559322 0.00938337801608579
GO:BP GO:0051336 regulation of hydrolase activity 0.00503875336267831 1321 133 22 0.165413533834586 0.0166540499621499
GO:BP GO:0043297 apical junction assembly 0.0051295698799004 88 63 4 0.0634920634920635 0.0454545454545455
GO:BP GO:0022610 biological adhesion 0.00520148602524297 1499 59 14 0.23728813559322 0.00933955970647098
GO:BP GO:1903322 positive regulation of protein modification by small protein conjugation or removal 0.00523390516880284 140 114 6 0.0526315789473684 0.0428571428571429
GO:BP GO:0051234 establishment of localization 0.00530736790440244 5372 131 58 0.442748091603053 0.0107967237527923
GO:BP GO:0051603 proteolysis involved in cellular protein catabolic process 0.00537460612181666 750 101 13 0.128712871287129 0.0173333333333333
GO:BP GO:0051047 positive regulation of secretion 0.00548993482593733 314 122 9 0.0737704918032787 0.0286624203821656
GO:BP GO:0006511 ubiquitin-dependent protein catabolic process 0.00553965984524734 655 101 12 0.118811881188119 0.0183206106870229
GO:BP GO:0010942 positive regulation of cell death 0.00553965984524734 684 111 13 0.117117117117117 0.0190058479532164
GO:BP GO:0032479 regulation of type I interferon production 0.00553965984524734 130 125 6 0.048 0.0461538461538462
GO:BP GO:0044265 cellular macromolecule catabolic process 0.00553965984524734 1231 125 20 0.16 0.016246953696182
GO:BP GO:0032606 type I interferon production 0.00571766135031413 131 125 6 0.048 0.0458015267175573
GO:BP GO:0035666 TRIF-dependent toll-like receptor signaling pathway 0.00572161282830246 30 79 3 0.0379746835443038 0.1
GO:BP GO:0050790 regulation of catalytic activity 0.00574271258403782 2545 133 34 0.255639097744361 0.0133595284872299
GO:BP GO:0032940 secretion by cell 0.00574271258403782 1364 131 22 0.16793893129771 0.0161290322580645
GO:BP GO:0044093 positive regulation of molecular function 0.00574806759288523 1771 144 28 0.194444444444444 0.0158102766798419
GO:BP GO:0007010 cytoskeleton organization 0.00579170671814956 1423 63 14 0.222222222222222 0.00983836964160225
GO:BP GO:0002682 regulation of immune system process 0.00579813929551587 1617 56 14 0.25 0.00865800865800866
GO:BP GO:0002720 positive regulation of cytokine production involved in immune response 0.00579813929551587 54 109 4 0.036697247706422 0.0740740740740741
GO:BP GO:0019941 modification-dependent protein catabolic process 0.0058059886488651 662 101 12 0.118811881188119 0.0181268882175227
GO:BP GO:0046596 regulation of viral entry into host cell 0.00580724359447565 43 56 3 0.0535714285714286 0.0697674418604651
GO:BP GO:1901564 organonitrogen compound metabolic process 0.00580724359447565 6792 127 67 0.52755905511811 0.00986454652532391
GO:BP GO:0002699 positive regulation of immune effector process 0.00588088779339366 215 109 7 0.0642201834862385 0.0325581395348837
GO:BP GO:0061025 membrane fusion 0.00592653074846757 179 131 7 0.0534351145038168 0.0391061452513966
GO:BP GO:0002697 regulation of immune effector process 0.00604573349629769 461 86 9 0.104651162790698 0.0195227765726681
GO:BP GO:0039535 regulation of RIG-I signaling pathway 0.00604573349629769 20 125 3 0.024 0.15
GO:BP GO:0007265 Ras protein signal transduction 0.00606302754797597 349 32 5 0.15625 0.0143266475644699
GO:BP GO:0051056 regulation of small GTPase mediated signal transduction 0.00608098526560159 328 34 5 0.147058823529412 0.0152439024390244
GO:BP GO:0097194 execution phase of apoptosis 0.00608897522499649 96 26 3 0.115384615384615 0.03125
GO:BP GO:0007264 small GTPase mediated signal transduction 0.00613755734259828 515 34 6 0.176470588235294 0.0116504854368932
GO:BP GO:0002931 response to ischemia 0.00613755734259828 58 43 3 0.0697674418604651 0.0517241379310345
GO:BP GO:0007005 mitochondrion organization 0.00613755734259828 561 57 8 0.140350877192982 0.0142602495543672
GO:BP GO:0043632 modification-dependent macromolecule catabolic process 0.00632455279756197 673 101 12 0.118811881188119 0.0178306092124814
GO:BP GO:0060544 regulation of necroptotic process 0.00635417724971561 28 91 3 0.032967032967033 0.107142857142857
GO:BP GO:0070265 necrotic cell death 0.00648434347563843 68 91 4 0.043956043956044 0.0588235294117647
GO:BP GO:0031396 regulation of protein ubiquitination 0.00648434347563843 211 114 7 0.0614035087719298 0.033175355450237
GO:BP GO:0032446 protein modification by small protein conjugation 0.00655170652559494 973 114 16 0.140350877192982 0.0164439876670093
GO:BP GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 0.00672875513044011 52 50 3 0.06 0.0576923076923077
GO:BP GO:0070647 protein modification by small protein conjugation or removal 0.00704454335171383 1184 114 18 0.157894736842105 0.0152027027027027
GO:BP GO:0051046 regulation of secretion 0.00706675486884793 647 122 13 0.10655737704918 0.0200927357032458
GO:BP GO:0039702 viral budding via host ESCRT complex 0.00713243705503752 21 129 3 0.0232558139534884 0.142857142857143
GO:BP GO:0002756 MyD88-independent toll-like receptor signaling pathway 0.00720250576127439 34 79 3 0.0379746835443038 0.0882352941176471
GO:BP GO:0048585 negative regulation of response to stimulus 0.00720764692036516 1733 114 23 0.201754385964912 0.0132717830351991
GO:BP GO:0032648 regulation of interferon-beta production 0.00745753452822975 52 125 4 0.032 0.0769230769230769
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.00767439048865445 6603 111 58 0.522522522522523 0.00878388611237316
GO:BP GO:0062098 regulation of programmed necrotic cell death 0.00809222877068382 31 91 3 0.032967032967033 0.0967741935483871
GO:BP GO:0043112 receptor metabolic process 0.00821537384855566 174 145 7 0.0482758620689655 0.0402298850574713
GO:BP GO:0032608 interferon-beta production 0.00839472657417208 54 125 4 0.032 0.0740740740740741
GO:BP GO:1903008 organelle disassembly 0.00844303389245383 107 27 3 0.111111111111111 0.0280373831775701
GO:BP GO:1902410 mitotic cytokinetic process 0.00891505583445217 23 129 3 0.0232558139534884 0.130434782608696
GO:BP GO:0098609 cell-cell adhesion 0.00892665485800641 894 59 10 0.169491525423729 0.0111856823266219
GO:BP GO:0051247 positive regulation of protein metabolic process 0.0089923712785732 1564 144 25 0.173611111111111 0.0159846547314578
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.00922840616273775 1477 144 24 0.166666666666667 0.016249153689912
GO:BP GO:0033043 regulation of organelle organization 0.00922840616273775 1203 145 21 0.144827586206897 0.0174563591022444
GO:BP GO:0043085 positive regulation of catalytic activity 0.00982341635157153 1418 133 22 0.165413533834586 0.0155148095909732
GO:BP GO:0044267 cellular protein metabolic process 0.0100876289696936 5229 144 60 0.416666666666667 0.0114744693057946
GO:BP GO:0003158 endothelium development 0.0100876289696936 143 133 6 0.0451127819548872 0.041958041958042
GO:BP GO:0048871 multicellular organismal homeostasis 0.0101996543726371 530 51 7 0.137254901960784 0.0132075471698113
GO:BP GO:0030036 actin cytoskeleton organization 0.0106372383866091 709 39 7 0.179487179487179 0.00987306064880113
GO:BP GO:0006622 protein targeting to lysosome 0.0109840384083501 23 141 3 0.0212765957446809 0.130434782608696
GO:BP GO:0039529 RIG-I signaling pathway 0.0111381629680379 26 125 3 0.024 0.115384615384615
GO:BP GO:0001885 endothelial cell development 0.0118570659729446 69 109 4 0.036697247706422 0.0579710144927536
GO:BP GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0118741429694622 138 95 5 0.0526315789473684 0.036231884057971
GO:BP GO:0061640 cytoskeleton-dependent cytokinesis 0.0119412595161846 102 129 5 0.0387596899224806 0.0490196078431373
GO:BP GO:0046755 viral budding 0.0119412595161846 26 129 3 0.0232558139534884 0.115384615384615
GO:BP GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels 0.0119412595161846 66 115 4 0.0347826086956522 0.0606060606060606
GO:BP GO:0036211 protein modification process 0.0119412595161846 4041 144 49 0.340277777777778 0.01212571145756
GO:BP GO:0006464 cellular protein modification process 0.0119412595161846 4041 144 49 0.340277777777778 0.01212571145756
GO:BP GO:0002274 myeloid leukocyte activation 0.0119412595161846 667 127 13 0.102362204724409 0.0194902548725637
GO:BP GO:0002705 positive regulation of leukocyte mediated immunity 0.0122452127883139 122 109 5 0.0458715596330275 0.040983606557377
GO:BP GO:0006810 transport 0.0122452127883139 5224 131 55 0.419847328244275 0.0105283307810107
GO:BP GO:0050776 regulation of immune response 0.0122452127883139 996 56 10 0.178571428571429 0.0100401606425703
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.0123373343675787 184 109 6 0.055045871559633 0.0326086956521739
GO:BP GO:0055001 muscle cell development 0.0132406547353217 184 43 4 0.0930232558139535 0.0217391304347826
GO:BP GO:0045446 endothelial cell differentiation 0.01344962271676 125 109 5 0.0458715596330275 0.04
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0135647209978279 290 126 8 0.0634920634920635 0.0275862068965517
GO:BP GO:0031398 positive regulation of protein ubiquitination 0.0135946921957745 120 114 5 0.043859649122807 0.0416666666666667
GO:BP GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0138045080301341 217 95 6 0.0631578947368421 0.0276497695852535
GO:BP GO:0002443 leukocyte mediated immunity 0.0140909735152716 877 112 14 0.125 0.015963511972634
GO:BP GO:0019222 regulation of metabolic process 0.0143099397345497 7148 52 32 0.615384615384615 0.00447677672076105
GO:BP GO:0043067 regulation of programmed cell death 0.014420708479882 1582 64 14 0.21875 0.00884955752212389
GO:BP GO:0035821 modulation of process of other organism 0.0144593043808105 128 109 5 0.0458715596330275 0.0390625
GO:BP GO:0030522 intracellular receptor signaling pathway 0.014814460278333 284 50 5 0.1 0.0176056338028169
GO:BP GO:0032880 regulation of protein localization 0.0153720846332244 922 145 17 0.117241379310345 0.0184381778741865
GO:BP GO:0030162 regulation of proteolysis 0.0154981421794673 752 103 12 0.116504854368932 0.0159574468085106
GO:BP GO:0043065 positive regulation of apoptotic process 0.0159669347685479 604 111 11 0.0990990990990991 0.0182119205298013
GO:BP GO:0019538 protein metabolic process 0.0159669347685479 5808 144 64 0.444444444444444 0.0110192837465565
GO:BP GO:0051091 positive regulation of DNA-binding transcription factor activity 0.0159940412661346 270 140 8 0.0571428571428571 0.0296296296296296
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.0162274836917587 197 109 6 0.055045871559633 0.0304568527918782
GO:BP GO:0045862 positive regulation of proteolysis 0.0164386587452601 378 101 8 0.0792079207920792 0.0211640211640212
GO:BP GO:0031331 positive regulation of cellular catabolic process 0.0166229157961436 393 145 10 0.0689655172413793 0.0254452926208651
GO:BP GO:0009896 positive regulation of catabolic process 0.0167930088427099 464 145 11 0.0758620689655172 0.0237068965517241
GO:BP GO:0007034 vacuolar transport 0.0168659379714317 154 141 6 0.0425531914893617 0.038961038961039
GO:BP GO:2001056 positive regulation of cysteine-type endopeptidase activity 0.0168659379714317 154 95 5 0.0526315789473684 0.0324675324675325
GO:BP GO:0071705 nitrogen compound transport 0.0170077651899407 2322 145 32 0.220689655172414 0.0137812230835487
GO:BP GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 0.017675106666286 92 95 4 0.0421052631578947 0.0434782608695652
GO:BP GO:0010939 regulation of necrotic cell death 0.0176821497311274 44 91 3 0.032967032967033 0.0681818181818182
GO:BP GO:0031399 regulation of protein modification process 0.0185636684576027 1671 144 25 0.173611111111111 0.0149611011370437
GO:BP GO:0030029 actin filament-based process 0.0189341359369171 808 39 7 0.179487179487179 0.00866336633663366
GO:BP GO:2000116 regulation of cysteine-type endopeptidase activity 0.0196322202729588 240 64 5 0.078125 0.0208333333333333
GO:BP GO:0009611 response to wounding 0.0203842043888888 674 47 7 0.148936170212766 0.0103857566765579
GO:BP GO:0051049 regulation of transport 0.0204599518099768 1809 113 22 0.194690265486726 0.0121614151464898
GO:BP GO:0006656 phosphatidylcholine biosynthetic process 0.020886727880887 39 110 3 0.0272727272727273 0.0769230769230769
GO:BP GO:0002718 regulation of cytokine production involved in immune response 0.0211032184403852 85 109 4 0.036697247706422 0.0470588235294118
GO:BP GO:0061024 membrane organization 0.0212654801717532 973 131 16 0.122137404580153 0.0164439876670093
GO:BP GO:0071702 organic substance transport 0.0212654801717532 2766 145 36 0.248275862068966 0.0130151843817787
GO:BP GO:0007041 lysosomal transport 0.0212654801717532 111 141 5 0.0354609929078014 0.045045045045045
GO:BP GO:0032879 regulation of localization 0.0213837791133101 2872 145 37 0.255172413793103 0.012883008356546
GO:BP GO:0032874 positive regulation of stress-activated MAPK cascade 0.021521106681116 121 130 5 0.0384615384615385 0.0413223140495868
GO:BP GO:0001819 positive regulation of cytokine production 0.0220243031025382 452 133 10 0.075187969924812 0.0221238938053097
GO:BP GO:0043331 response to dsRNA 0.0220699055886812 56 79 3 0.0379746835443038 0.0535714285714286
GO:BP GO:0000281 mitotic cytokinesis 0.0225091741551919 74 129 4 0.0310077519379845 0.0540540540540541
GO:BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 0.0226151927694554 123 130 5 0.0384615384615385 0.040650406504065
GO:BP GO:0071216 cellular response to biotic stimulus 0.0227371386390652 238 99 6 0.0606060606060606 0.0252100840336134
GO:BP GO:0006820 anion transport 0.0228326096439692 2889 145 37 0.255172413793103 0.0128071997230876
GO:BP GO:0051246 regulation of protein metabolic process 0.0229319008306198 2704 144 35 0.243055555555556 0.0129437869822485
GO:BP GO:0002064 epithelial cell development 0.0233626238932572 218 109 6 0.055045871559633 0.0275229357798165
GO:BP GO:0044087 regulation of cellular component biogenesis 0.0237158604076494 990 131 16 0.122137404580153 0.0161616161616162
GO:BP GO:0008637 apoptotic mitochondrial changes 0.0240918140579312 126 37 3 0.0810810810810811 0.0238095238095238
GO:BP GO:0031401 positive regulation of protein modification process 0.0242903181771536 1074 144 18 0.125 0.0167597765363128
GO:BP GO:0006887 exocytosis 0.024891908570926 904 144 16 0.111111111111111 0.0176991150442478
GO:BP GO:0060249 anatomical structure homeostasis 0.024891908570926 482 51 6 0.117647058823529 0.012448132780083
GO:BP GO:1903902 positive regulation of viral life cycle 0.0249976929524913 34 140 3 0.0214285714285714 0.0882352941176471
GO:BP GO:0022607 cellular component assembly 0.0249976929524913 3010 131 35 0.267175572519084 0.0116279069767442
GO:BP GO:0055002 striated muscle cell development 0.0253892936606863 111 43 3 0.0697674418604651 0.027027027027027
GO:BP GO:0034613 cellular protein localization 0.0255375085702711 2014 131 26 0.198473282442748 0.012909632571996
GO:BP GO:0010941 regulation of cell death 0.0255375085702711 1720 64 14 0.21875 0.00813953488372093
GO:BP GO:0044085 cellular component biogenesis 0.0267419246252021 3257 131 37 0.282442748091603 0.0113601473748849
GO:BP GO:0002367 cytokine production involved in immune response 0.0268526823013308 94 109 4 0.036697247706422 0.0425531914893617
GO:BP GO:0070727 cellular macromolecule localization 0.0268793842500994 2024 131 26 0.198473282442748 0.0128458498023715
GO:BP GO:0072665 protein localization to vacuole 0.0270119304307752 71 145 4 0.0275862068965517 0.0563380281690141
GO:BP GO:0043412 macromolecule modification 0.0276989315375903 4257 144 49 0.340277777777778 0.0115104533709185
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0276989315375903 2541 144 33 0.229166666666667 0.012987012987013
GO:BP GO:0042981 regulation of apoptotic process 0.0276989315375903 1549 64 13 0.203125 0.00839251129761136
GO:BP GO:0042060 wound healing 0.0288009035263919 549 47 6 0.127659574468085 0.0109289617486339
GO:BP GO:0000910 cytokinesis 0.0288009035263919 174 145 6 0.0413793103448276 0.0344827586206897
GO:BP GO:0017157 regulation of exocytosis 0.0288009035263919 207 122 6 0.0491803278688525 0.0289855072463768
GO:BP GO:0031323 regulation of cellular metabolic process 0.0288324355215337 6269 111 53 0.477477477477477 0.008454298931249
GO:BP GO:0019068 virion assembly 0.0289906610056923 40 129 3 0.0232558139534884 0.075
GO:BP GO:0022411 cellular component disassembly 0.029167357931425 571 131 11 0.083969465648855 0.0192644483362522
GO:BP GO:2000377 regulation of reactive oxygen species metabolic process 0.0296182002906667 203 126 6 0.0476190476190476 0.0295566502463054
GO:BP GO:1903053 regulation of extracellular matrix organization 0.0296182002906667 47 111 3 0.027027027027027 0.0638297872340425
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.0300881564739581 187 95 5 0.0526315789473684 0.0267379679144385
GO:BP GO:0002702 positive regulation of production of molecular mediator of immune response 0.0304019802417829 100 109 4 0.036697247706422 0.04
GO:BP GO:0016197 endosomal transport 0.0307569132163332 246 141 7 0.049645390070922 0.0284552845528455
GO:BP GO:0051641 cellular localization 0.0309312650411807 3541 131 39 0.297709923664122 0.0110138378988986
GO:BP GO:0010508 positive regulation of autophagy 0.0309312650411807 124 145 5 0.0344827586206897 0.0403225806451613
GO:BP GO:0030198 extracellular matrix organization 0.0311545807085514 401 111 8 0.0720720720720721 0.0199501246882793
GO:BP GO:0045321 leukocyte activation 0.0311545807085514 1332 112 17 0.151785714285714 0.0127627627627628
GO:BP GO:0043062 extracellular structure organization 0.031168876423581 402 111 8 0.0720720720720721 0.0199004975124378
GO:BP GO:0009628 response to abiotic stimulus 0.0316015107928583 1261 62 11 0.17741935483871 0.00872323552735924
GO:BP GO:0006954 inflammatory response 0.0317312447390864 794 111 12 0.108108108108108 0.0151133501259446
GO:BP GO:0045229 external encapsulating structure organization 0.0317312447390864 404 111 8 0.0720720720720721 0.0198019801980198
GO:BP GO:0052548 regulation of endopeptidase activity 0.0320289825624822 437 103 8 0.0776699029126214 0.0183066361556064
GO:BP GO:0061912 selective autophagy 0.0328010040652097 63 88 3 0.0340909090909091 0.0476190476190476
GO:BP GO:0001912 positive regulation of leukocyte mediated cytotoxicity 0.0328404212919686 51 109 3 0.0275229357798165 0.0588235294117647
GO:BP GO:0050856 regulation of T cell receptor signaling pathway 0.0329943627522126 42 133 3 0.0225563909774436 0.0714285714285714
GO:BP GO:0006623 protein targeting to vacuole 0.033577361500945 40 141 3 0.0212765957446809 0.075
GO:BP GO:0010718 positive regulation of epithelial to mesenchymal transition 0.0339710353406835 51 111 3 0.027027027027027 0.0588235294117647
GO:BP GO:0034612 response to tumor necrosis factor 0.0348934571453312 331 109 7 0.0642201834862385 0.0211480362537764
GO:BP GO:0050829 defense response to Gram-negative bacterium 0.0350908331528742 88 132 4 0.0303030303030303 0.0454545454545455
GO:BP GO:0043066 negative regulation of apoptotic process 0.0350908331528742 921 62 9 0.145161290322581 0.00977198697068404
GO:BP GO:0045055 regulated exocytosis 0.0353012964494023 785 144 14 0.0972222222222222 0.0178343949044586
GO:BP GO:0080090 regulation of primary metabolic process 0.0353026008702944 6053 111 51 0.459459459459459 0.00842557409548984
GO:BP GO:0010824 regulation of centrosome duplication 0.0354949523931058 45 129 3 0.0232558139534884 0.0666666666666667
GO:BP GO:0006996 organelle organization 0.0355405197789792 4104 40 17 0.425 0.00414230019493177
GO:BP GO:0014706 striated muscle tissue development 0.0366470159037936 380 51 5 0.0980392156862745 0.0131578947368421
GO:BP GO:0090559 regulation of membrane permeability 0.037924531691882 95 63 3 0.0476190476190476 0.0315789473684211
GO:BP GO:1902115 regulation of organelle assembly 0.038333942323771 192 145 6 0.0413793103448276 0.03125
GO:BP GO:0010952 positive regulation of peptidase activity 0.038333942323771 205 95 5 0.0526315789473684 0.024390243902439
GO:BP GO:0010463 mesenchymal cell proliferation 0.038333942323771 42 144 3 0.0208333333333333 0.0714285714285714
GO:BP GO:0000302 response to reactive oxygen species 0.0386030814374974 237 26 3 0.115384615384615 0.0126582278481013
GO:BP GO:0097190 apoptotic signaling pathway 0.0386030814374974 600 114 10 0.087719298245614 0.0166666666666667
GO:BP GO:0043069 negative regulation of programmed cell death 0.0386030814374974 943 62 9 0.145161290322581 0.0095440084835631
GO:BP GO:0001775 cell activation 0.0386604882461516 1495 112 18 0.160714285714286 0.0120401337792642
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 0.0387198091236434 1617 51 11 0.215686274509804 0.00680272108843537
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 0.0387198091236434 1617 51 11 0.215686274509804 0.00680272108843537
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 0.0387273055473209 1618 51 11 0.215686274509804 0.00679851668726823
GO:BP GO:0050688 regulation of defense response to virus 0.0387273055473209 71 86 3 0.0348837209302326 0.0422535211267606
GO:BP GO:0042692 muscle cell differentiation 0.0387672842384747 390 51 5 0.0980392156862745 0.0128205128205128
GO:BP GO:0001763 morphogenesis of a branching structure 0.0387672842384747 195 144 6 0.0416666666666667 0.0307692307692308
GO:BP GO:0051146 striated muscle cell differentiation 0.0393671469761411 289 43 4 0.0930232558139535 0.013840830449827
GO:BP GO:0071222 cellular response to lipopolysaccharide 0.0394029771078948 200 99 5 0.0505050505050505 0.025
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 0.039803033383314 1887 111 21 0.189189189189189 0.0111287758346582
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0403645222889198 783 133 13 0.0977443609022556 0.016602809706258
GO:BP GO:0046605 regulation of centrosome cycle 0.0403840279435544 49 129 3 0.0232558139534884 0.0612244897959184
GO:BP GO:0060537 muscle tissue development 0.0403840279435544 399 51 5 0.0980392156862745 0.012531328320802
GO:BP GO:0002684 positive regulation of immune system process 0.0403840279435544 1065 56 9 0.160714285714286 0.00845070422535211
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0403840279435544 547 127 10 0.078740157480315 0.0182815356489945
GO:BP GO:0052547 regulation of peptidase activity 0.0403840279435544 467 103 8 0.0776699029126214 0.0171306209850107
GO:BP GO:0051656 establishment of organelle localization 0.0403840279435544 445 131 9 0.0687022900763359 0.0202247191011236
GO:BP GO:0000209 protein polyubiquitination 0.0403840279435544 342 140 8 0.0571428571428571 0.0233918128654971
GO:BP GO:0043170 macromolecule metabolic process 0.0403840279435544 9796 98 66 0.673469387755102 0.00673744385463454
GO:BP GO:0031023 microtubule organizing center organization 0.0403840279435544 142 141 5 0.0354609929078014 0.0352112676056338
GO:BP GO:0031343 positive regulation of cell killing 0.041643518715966 59 109 3 0.0275229357798165 0.0508474576271186
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0418963564785876 551 127 10 0.078740157480315 0.0181488203266788
GO:BP GO:0051865 protein autoubiquitination 0.0418963564785876 75 86 3 0.0348837209302326 0.04
GO:BP GO:0061462 protein localization to lysosome 0.0418963564785876 46 141 3 0.0212765957446809 0.0652173913043478
GO:BP GO:0045017 glycerolipid biosynthetic process 0.0419987403078391 268 144 7 0.0486111111111111 0.0261194029850746
GO:BP GO:0006811 ion transport 0.0422075112239153 3661 131 39 0.297709923664122 0.0106528270964217
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0422075112239153 5848 111 49 0.441441441441441 0.00837893296853625
GO:BP GO:0031623 receptor internalization 0.0422914961073123 116 57 3 0.0526315789473684 0.0258620689655172
GO:BP GO:0019637 organophosphate metabolic process 0.0422928298759863 1041 21 5 0.238095238095238 0.0048030739673391
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.0442562379076156 306 44 4 0.0909090909090909 0.0130718954248366
GO:BP GO:0071219 cellular response to molecule of bacterial origin 0.0442562379076156 214 99 5 0.0505050505050505 0.0233644859813084
GO:BP GO:0008333 endosome to lysosome transport 0.0442562379076156 53 129 3 0.0232558139534884 0.0566037735849057
GO:BP GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway 0.0444194897982758 63 109 3 0.0275229357798165 0.0476190476190476
GO:BP GO:2000379 positive regulation of reactive oxygen species metabolic process 0.0452606695525599 107 126 4 0.0317460317460317 0.0373831775700935
GO:BP GO:0035148 tube formation 0.0456122389184502 152 89 4 0.0449438202247191 0.0263157894736842
GO:BP GO:0007416 synapse assembly 0.0459797250592863 180 39 3 0.0769230769230769 0.0166666666666667
GO:BP GO:0003170 heart valve development 0.0460193469083452 63 111 3 0.027027027027027 0.0476190476190476
GO:BP GO:0044260 cellular macromolecule metabolic process 0.0477108024537584 8390 125 72 0.576 0.00858164481525626
GO:BP GO:0051254 positive regulation of RNA metabolic process 0.0477108024537584 1714 51 11 0.215686274509804 0.00641773628938156
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.0477108024537584 159 45 3 0.0666666666666667 0.0188679245283019
GO:BP GO:0032637 interleukin-8 production 0.0478230825287067 104 133 4 0.0300751879699248 0.0384615384615385
GO:BP GO:0032355 response to estradiol 0.0480500998079385 141 51 3 0.0588235294117647 0.0212765957446809
GO:BP GO:0050729 positive regulation of inflammatory response 0.0482196446442264 142 98 4 0.0408163265306122 0.028169014084507
GO:BP GO:0006898 receptor-mediated endocytosis 0.0482196446442264 333 122 7 0.0573770491803279 0.021021021021021
GO:BP GO:0044088 regulation of vacuole organization 0.0483366810370918 50 145 3 0.0206896551724138 0.06
GO:BP GO:0051252 regulation of RNA metabolic process 0.0488042349608302 3822 52 19 0.365384615384615 0.00497121925693354
GO:BP GO:0006900 vesicle budding from membrane 0.0489175914967984 107 131 4 0.0305343511450382 0.0373831775700935
GO:BP GO:0043393 regulation of protein binding 0.0490134923156064 199 111 5 0.045045045045045 0.0251256281407035
GO:BP GO:0072666 establishment of protein localization to vacuole 0.0495591279818132 52 141 3 0.0212765957446809 0.0576923076923077
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 0.0495954352910078 1967 111 21 0.189189189189189 0.0106761565836299
GO:BP GO:0043269 regulation of ion transport 0.0495954352910078 1379 55 10 0.181818181818182 0.00725163161711385
GO:BP GO:0000045 autophagosome assembly 0.0495954352910078 98 145 4 0.0275862068965517 0.0408163265306122
GO:BP GO:0002703 regulation of leukocyte mediated immunity 0.0496488047114865 205 109 5 0.0458715596330275 0.024390243902439
GO:CC GO:0005829 cytosol 1.019987744509e-07 5303 57 39 0.684210526315789 0.00735432773901565
GO:CC GO:0005737 cytoplasm 4.14084593915289e-07 11911 131 113 0.862595419847328 0.00948702879691042
GO:CC GO:0043296 apical junction complex 4.20740468499301e-07 145 72 9 0.125 0.0620689655172414
GO:CC GO:0005911 cell-cell junction 4.20740468499301e-07 494 72 14 0.194444444444444 0.0283400809716599
GO:CC GO:0070161 anchoring junction 7.24658523488389e-07 836 80 18 0.225 0.0215311004784689
GO:CC GO:0005923 bicellular tight junction 1.42709221996595e-06 123 72 8 0.111111111111111 0.0650406504065041
GO:CC GO:0070160 tight junction 2.00569982795384e-06 131 72 8 0.111111111111111 0.0610687022900763
GO:CC GO:0031982 vesicle 2.05455510026037e-06 4055 145 60 0.413793103448276 0.0147965474722565
GO:CC GO:0012505 endomembrane system 2.87959944043474e-06 4640 145 65 0.448275862068966 0.0140086206896552
GO:CC GO:0097708 intracellular vesicle 1.95342901836168e-05 2428 145 41 0.282758620689655 0.0168863261943987
GO:CC GO:0031410 cytoplasmic vesicle 1.95342901836168e-05 2424 145 41 0.282758620689655 0.0169141914191419
GO:CC GO:0043227 membrane-bounded organelle 3.67767415846287e-05 12858 117 102 0.871794871794872 0.00793280447970135
GO:CC GO:0097342 ripoptosome 4.30978915961588e-05 6 79 3 0.0379746835443038 0.5
GO:CC GO:1903561 extracellular vesicle 7.75961571558826e-05 2261 131 35 0.267175572519084 0.0154798761609907
GO:CC GO:0043230 extracellular organelle 7.75961571558826e-05 2263 131 35 0.267175572519084 0.0154661953159523
GO:CC GO:0070062 extracellular exosome 8.43406759722333e-05 2176 131 34 0.259541984732824 0.015625
GO:CC GO:0005773 vacuole 8.81688561896145e-05 810 145 20 0.137931034482759 0.0246913580246914
GO:CC GO:0048770 pigment granule 0.000100320740864564 105 122 7 0.0573770491803279 0.0666666666666667
GO:CC GO:0042470 melanosome 0.000100320740864564 105 122 7 0.0573770491803279 0.0666666666666667
GO:CC GO:0043226 organelle 0.000100320740864564 14008 117 106 0.905982905982906 0.0075671045117076
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.000100320740864564 11296 116 92 0.793103448275862 0.00814447592067989
GO:CC GO:0031981 nuclear lumen 0.000134774909003268 4444 36 21 0.583333333333333 0.00472547254725473
GO:CC GO:0005622 intracellular anatomical structure 0.000156967234855914 14790 131 121 0.923664122137405 0.00818120351588911
GO:CC GO:0070013 intracellular organelle lumen 0.000178054397582204 5402 36 23 0.638888888888889 0.00425768233987412
GO:CC GO:0005912 adherens junction 0.000191176359343118 173 56 6 0.107142857142857 0.0346820809248555
GO:CC GO:0043229 intracellular organelle 0.000237530186639061 12491 116 97 0.836206896551724 0.00776559122568249
GO:CC GO:0031974 membrane-enclosed lumen 0.000261573804390711 5565 36 23 0.638888888888889 0.0041329739442947
GO:CC GO:0043233 organelle lumen 0.000261573804390711 5565 36 23 0.638888888888889 0.0041329739442947
GO:CC GO:0016327 apicolateral plasma membrane 0.000368589147008369 22 51 3 0.0588235294117647 0.136363636363636
GO:CC GO:0098857 membrane microdomain 0.000368881064618813 335 51 7 0.137254901960784 0.0208955223880597
GO:CC GO:0030054 cell junction 0.000368881064618813 2105 73 21 0.287671232876712 0.00997624703087886
GO:CC GO:0045121 membrane raft 0.000368881064618813 335 51 7 0.137254901960784 0.0208955223880597
GO:CC GO:0005654 nucleoplasm 0.00048270868307101 4102 36 19 0.527777777777778 0.00463188688444661
GO:CC GO:0005768 endosome 0.000605456588404987 987 143 20 0.13986013986014 0.0202634245187437
GO:CC GO:0030055 cell-substrate junction 0.000871581366763568 427 80 9 0.1125 0.0210772833723653
GO:CC GO:0005776 autophagosome 0.000995371429783221 98 88 5 0.0568181818181818 0.0510204081632653
GO:CC GO:0005794 Golgi apparatus 0.000995371429783221 1623 145 27 0.186206896551724 0.0166358595194085
GO:CC GO:0005886 plasma membrane 0.00154596934493661 5681 133 60 0.451127819548872 0.0105615208590037
GO:CC GO:0005604 basement membrane 0.00218521695985253 97 24 3 0.125 0.0309278350515464
GO:CC GO:0005615 extracellular space 0.00218521695985253 3594 131 42 0.320610687022901 0.011686143572621
GO:CC GO:0030017 sarcomere 0.00218521695985253 208 51 5 0.0980392156862745 0.0240384615384615
GO:CC GO:0005730 nucleolus 0.00218521695985253 955 19 6 0.315789473684211 0.00628272251308901
GO:CC GO:0010008 endosome membrane 0.00263840687505308 505 137 12 0.0875912408759124 0.0237623762376238
GO:CC GO:0000323 lytic vacuole 0.00264749350188169 712 143 15 0.104895104895105 0.0210674157303371
GO:CC GO:0005764 lysosome 0.00264749350188169 712 143 15 0.104895104895105 0.0210674157303371
GO:CC GO:0030018 Z disc 0.00296329018610276 126 51 4 0.0784313725490196 0.0317460317460317
GO:CC GO:0030016 myofibril 0.00304558283611374 231 51 5 0.0980392156862745 0.0216450216450216
GO:CC GO:0005925 focal adhesion 0.00304641268417713 420 80 8 0.1 0.019047619047619
GO:CC GO:0043292 contractile fiber 0.00342511398377246 240 51 5 0.0980392156862745 0.0208333333333333
GO:CC GO:0016605 PML body 0.00344412239842669 102 67 4 0.0597014925373134 0.0392156862745098
GO:CC GO:0071944 cell periphery 0.00348906840978332 6169 133 62 0.466165413533835 0.0100502512562814
GO:CC GO:0009925 basal plasma membrane 0.00364157136614761 247 51 5 0.0980392156862745 0.0202429149797571
GO:CC GO:0031674 I band 0.00364157136614761 139 51 4 0.0784313725490196 0.0287769784172662
GO:CC GO:0031252 cell leading edge 0.00364157136614761 422 126 10 0.0793650793650794 0.023696682464455
GO:CC GO:0016020 membrane 0.00402425124792591 9838 145 95 0.655172413793103 0.00965643423460053
GO:CC GO:0098590 plasma membrane region 0.00431847476314236 1240 24 7 0.291666666666667 0.00564516129032258
GO:CC GO:0045178 basal part of cell 0.00467402239788294 265 51 5 0.0980392156862745 0.0188679245283019
GO:CC GO:0048471 perinuclear region of cytoplasm 0.00768039467692713 735 55 8 0.145454545454545 0.0108843537414966
GO:CC GO:0044291 cell-cell contact zone 0.00865132878081731 74 56 3 0.0535714285714286 0.0405405405405405
GO:CC GO:0030670 phagocytic vesicle membrane 0.00914807826536144 76 122 4 0.0327868852459016 0.0526315789473684
GO:CC GO:0005576 extracellular region 0.00984520004611586 4567 131 47 0.358778625954198 0.0102912196190059
GO:CC GO:0098588 bounding membrane of organelle 0.0103152611877851 2158 145 29 0.2 0.0134383688600556
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0105340922304639 421 24 4 0.166666666666667 0.00950118764845606
GO:CC GO:0005938 cell cortex 0.0113752755878851 311 55 5 0.0909090909090909 0.0160771704180064
GO:CC GO:0005765 lysosomal membrane 0.0113752755878851 383 88 7 0.0795454545454545 0.0182767624020888
GO:CC GO:0098852 lytic vacuole membrane 0.0113752755878851 383 88 7 0.0795454545454545 0.0182767624020888
GO:CC GO:0005770 late endosome 0.0118483023507926 275 92 6 0.0652173913043478 0.0218181818181818
GO:CC GO:0031902 late endosome membrane 0.0140786228477563 140 129 5 0.0387596899224806 0.0357142857142857
GO:CC GO:0098858 actin-based cell projection 0.0147852570987499 220 51 4 0.0784313725490196 0.0181818181818182
GO:CC GO:0016323 basolateral plasma membrane 0.0150829756652417 222 51 4 0.0784313725490196 0.018018018018018
GO:CC GO:0005634 nucleus 0.0161049450601122 7592 36 23 0.638888888888889 0.00302950474183351
GO:CC GO:0098791 Golgi apparatus subcompartment 0.0161049450601122 885 145 15 0.103448275862069 0.0169491525423729
GO:CC GO:0030139 endocytic vesicle 0.0172766544381365 306 122 7 0.0573770491803279 0.0228758169934641
GO:CC GO:0031975 envelope 0.0172766544381365 1237 24 6 0.25 0.00485044462409054
GO:CC GO:0031967 organelle envelope 0.0172766544381365 1237 24 6 0.25 0.00485044462409054
GO:CC GO:0030666 endocytic vesicle membrane 0.0172766544381365 159 122 5 0.040983606557377 0.0314465408805031
GO:CC GO:0042582 azurophil granule 0.0173616086605767 154 127 5 0.0393700787401575 0.0324675324675325
GO:CC GO:0005766 primary lysosome 0.0173616086605767 154 127 5 0.0393700787401575 0.0324675324675325
GO:CC GO:0005774 vacuolar membrane 0.0195111947069729 441 88 7 0.0795454545454545 0.0158730158730159
GO:CC GO:0005739 mitochondrion 0.0203851225905894 1673 25 7 0.28 0.00418410041841004
GO:CC GO:0030312 external encapsulating structure 0.0213265255513421 563 24 4 0.166666666666667 0.00710479573712256
GO:CC GO:0031012 extracellular matrix 0.0213265255513421 562 24 4 0.166666666666667 0.00711743772241993
GO:CC GO:0045177 apical part of cell 0.0238860605707511 431 51 5 0.0980392156862745 0.0116009280742459
GO:CC GO:0015629 actin cytoskeleton 0.0238860605707511 513 122 9 0.0737704918032787 0.0175438596491228
GO:CC GO:0000139 Golgi membrane 0.024561554889186 771 145 13 0.0896551724137931 0.0168612191958495
GO:CC GO:0005769 early endosome 0.024561554889186 378 137 8 0.0583941605839416 0.0211640211640212
GO:CC GO:0005635 nuclear envelope 0.0289877526531509 467 32 4 0.125 0.00856531049250535
GO:CC GO:0016324 apical plasma membrane 0.0300169537725088 361 22 3 0.136363636363636 0.00831024930747922
GO:CC GO:0000151 ubiquitin ligase complex 0.0310657481650434 297 112 6 0.0535714285714286 0.0202020202020202
GO:CC GO:0005811 lipid droplet 0.0347244746768171 95 88 3 0.0340909090909091 0.0315789473684211
GO:CC GO:0045335 phagocytic vesicle 0.0398921790816124 137 122 4 0.0327868852459016 0.0291970802919708
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.0398921790816124 5338 76 31 0.407894736842105 0.0058074185088048
GO:CC GO:0043228 non-membrane-bounded organelle 0.0402729435758709 5346 76 31 0.407894736842105 0.00579872802095024
GO:CC GO:0031090 organelle membrane 0.0420163434851623 3612 145 39 0.268965517241379 0.010797342192691
GO:CC GO:0012506 vesicle membrane 0.0439144908581163 800 122 11 0.0901639344262295 0.01375
GO:CC GO:0031984 organelle subcompartment 0.0475919275649146 1773 145 22 0.151724137931034 0.0124083474337281
GO:CC GO:0005887 integral component of plasma membrane 0.0479363862842023 1645 18 5 0.277777777777778 0.00303951367781155
GO:CC GO:0099512 supramolecular fiber 0.0481782890663202 993 51 7 0.137254901960784 0.00704934541792548
GO:CC GO:0099081 supramolecular polymer 0.0497831442460839 1001 51 7 0.137254901960784 0.00699300699300699
GO:MF GO:0042802 identical protein binding 2.1515932025225e-06 2067 98 32 0.326530612244898 0.01548137397194
GO:MF GO:0050839 cell adhesion molecule binding 2.1515932025225e-06 546 129 19 0.147286821705426 0.0347985347985348
GO:MF GO:0001730 2'-5'-oligoadenylate synthetase activity 1.34919338672759e-05 4 52 3 0.0576923076923077 0.75
GO:MF GO:0045296 cadherin binding 4.14262898782975e-05 333 145 14 0.096551724137931 0.042042042042042
GO:MF GO:0008022 protein C-terminus binding 0.000120263483538527 202 51 7 0.137254901960784 0.0346534653465347
GO:MF GO:0001618 virus receptor activity 0.00078227075574338 76 71 5 0.0704225352112676 0.0657894736842105
GO:MF GO:0140272 exogenous protein binding 0.00078227075574338 77 71 5 0.0704225352112676 0.0649350649350649
GO:MF GO:0003725 double-stranded RNA binding 0.00229297001017823 77 91 5 0.0549450549450549 0.0649350649350649
GO:MF GO:0042803 protein homodimerization activity 0.00256675150537478 676 97 13 0.134020618556701 0.0192307692307692
GO:MF GO:0019904 protein domain specific binding 0.002729016213449 710 94 13 0.138297872340426 0.0183098591549296
GO:MF GO:0031593 polyubiquitin modification-dependent protein binding 0.00359690963658277 52 31 3 0.0967741935483871 0.0576923076923077
GO:MF GO:0005515 protein binding 0.00359690963658277 14767 145 132 0.910344827586207 0.00893885013882305
GO:MF GO:0046983 protein dimerization activity 0.00391038220463787 1069 97 16 0.164948453608247 0.0149672591206735
GO:MF GO:0005102 signaling receptor binding 0.00391038220463787 1672 34 11 0.323529411764706 0.00657894736842105
GO:MF GO:0070566 adenylyltransferase activity 0.00391038220463787 33 52 3 0.0576923076923077 0.0909090909090909
GO:MF GO:0019899 enzyme binding 0.00655299356862038 2074 113 26 0.230088495575221 0.0125361620057859
GO:MF GO:0043621 protein self-association 0.00916878419055596 56 45 3 0.0666666666666667 0.0535714285714286
GO:MF GO:0044877 protein-containing complex binding 0.00969995712774027 1287 34 9 0.264705882352941 0.00699300699300699
GO:MF GO:0044389 ubiquitin-like protein ligase binding 0.0198020989505291 314 97 7 0.0721649484536082 0.0222929936305732
GO:MF GO:0043169 cation binding 0.0198020989505291 4351 27 14 0.518518518518518 0.00321765111468628
GO:MF GO:0005178 integrin binding 0.0198020989505291 147 28 3 0.107142857142857 0.0204081632653061
GO:MF GO:0016772 transferase activity, transferring phosphorus-containing groups 0.0198020989505291 952 25 6 0.24 0.00630252100840336
GO:MF GO:0004842 ubiquitin-protein transferase activity 0.0198020989505291 442 90 8 0.0888888888888889 0.0180995475113122
GO:MF GO:0005126 cytokine receptor binding 0.0202764892979071 275 34 4 0.117647058823529 0.0145454545454545
GO:MF GO:0019787 ubiquitin-like protein transferase activity 0.0214104049206935 465 90 8 0.0888888888888889 0.0172043010752688
GO:MF GO:0008013 beta-catenin binding 0.0214104049206935 87 51 3 0.0588235294117647 0.0344827586206897
GO:MF GO:0043167 ion binding 0.0214104049206935 6057 103 48 0.466019417475728 0.0079247152055473
GO:MF GO:0070851 growth factor receptor binding 0.0239328520566189 143 34 3 0.0882352941176471 0.020979020979021
GO:MF GO:0140030 modification-dependent protein binding 0.0246451721056383 160 31 3 0.0967741935483871 0.01875
GO:MF GO:0016740 transferase activity 0.0253722939467478 2357 25 9 0.36 0.00381841323716589
GO:MF GO:0016788 hydrolase activity, acting on ester bonds 0.031084850917092 773 16 4 0.25 0.00517464424320828
GO:MF GO:0031625 ubiquitin protein ligase binding 0.031084850917092 296 64 5 0.078125 0.0168918918918919
GO:MF GO:0005488 binding 0.031084850917092 17074 109 107 0.981651376146789 0.00626683846784585
GO:MF GO:0046872 metal ion binding 0.031084850917092 4260 27 13 0.481481481481481 0.00305164319248826
GO:MF GO:0003824 catalytic activity 0.0331014375343103 5896 30 17 0.566666666666667 0.00288331071913161
GO:MF GO:0017111 nucleoside-triphosphatase activity 0.0332816082781467 872 93 11 0.118279569892473 0.0126146788990826
GO:MF GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0355536517455561 930 93 11 0.118279569892473 0.0118279569892473
GO:MF GO:0016817 hydrolase activity, acting on acid anhydrides 0.0355536517455561 930 93 11 0.118279569892473 0.0118279569892473
GO:MF GO:0016462 pyrophosphatase activity 0.0355536517455561 928 93 11 0.118279569892473 0.0118534482758621
GO:MF GO:0008270 zinc ion binding 0.0355536517455561 833 38 6 0.157894736842105 0.00720288115246098
GO:MF GO:0004386 helicase activity 0.0355536517455561 162 82 4 0.0487804878048781 0.0246913580246914
GO:MF GO:1901265 nucleoside phosphate binding 0.0355536517455561 2172 108 22 0.203703703703704 0.0101289134438306
GO:MF GO:0003724 RNA helicase activity 0.0355536517455561 76 82 3 0.0365853658536585 0.0394736842105263
GO:MF GO:0002020 protease binding 0.0355536517455561 133 50 3 0.06 0.0225563909774436
GO:MF GO:0000166 nucleotide binding 0.0355536517455561 2171 108 22 0.203703703703704 0.0101335789958544
GO:MF GO:0032553 ribonucleotide binding 0.0372639428315788 1935 108 20 0.185185185185185 0.0103359173126615
GO:MF GO:0140098 catalytic activity, acting on RNA 0.0382365155444527 395 82 6 0.0731707317073171 0.0151898734177215
GO:MF GO:0035639 purine ribonucleoside triphosphate binding 0.0427138194125711 1847 108 19 0.175925925925926 0.010286951813752
GO:MF GO:0030674 protein-macromolecule adaptor activity 0.0431628213996052 266 32 3 0.09375 0.0112781954887218
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.0431628213996052 281 87 5 0.0574712643678161 0.0177935943060498
GO:MF GO:0043168 anion binding 0.0431628213996052 2418 102 22 0.215686274509804 0.00909842845326716
GO:MF GO:0019209 kinase activator activity 0.0441362094997451 91 94 3 0.0319148936170213 0.032967032967033
GO:MF GO:0046914 transition metal ion binding 0.0475995049129946 1111 53 8 0.150943396226415 0.0072007200720072
GO:MF GO:0004540 ribonuclease activity 0.0477986604866669 111 82 3 0.0365853658536585 0.027027027027027
GO:MF GO:0016773 phosphotransferase activity, alcohol group as acceptor 0.0477986604866669 692 25 4 0.16 0.00578034682080925
GO:MF GO:0019003 GDP binding 0.0477986604866669 75 122 3 0.0245901639344262 0.04
GO:MF GO:0030234 enzyme regulator activity 0.0477986604866669 1248 130 16 0.123076923076923 0.0128205128205128
GO:MF GO:0032555 purine ribonucleotide binding 0.0481765070839011 1918 108 19 0.175925925925926 0.00990615224191867
KEGG KEGG:05160 Hepatitis C 2.76149669366158e-05 157 59 10 0.169491525423729 0.0636942675159236
KEGG KEGG:05164 Influenza A 0.00181504498025896 169 57 8 0.140350877192982 0.0473372781065089
KEGG KEGG:04217 Necroptosis 0.00481505332004563 159 143 11 0.0769230769230769 0.0691823899371069
KEGG KEGG:04621 NOD-like receptor signaling pathway 0.00481505332004563 177 36 6 0.166666666666667 0.0338983050847458
MIRNA MIRNA:hsa-miR-146a-5p hsa-miR-146a-5p 0.00149176156329765 200 57 8 0.140350877192982 0.04
MIRNA MIRNA:hsa-miR-629-5p hsa-miR-629-5p 0.00166176014650329 62 50 5 0.1 0.0806451612903226
MIRNA MIRNA:hsa-miR-548ah-5p hsa-miR-548ah-5p 0.0292639836719416 318 145 12 0.0827586206896552 0.0377358490566038
MIRNA MIRNA:hsa-miR-3609 hsa-miR-3609 0.0292639836719416 319 145 12 0.0827586206896552 0.0376175548589342
REAC REAC:R-HSA-909733 Interferon alpha/beta signaling 1.47178267960629e-11 66 57 11 0.192982456140351 0.166666666666667
REAC REAC:R-HSA-913531 Interferon Signaling 2.04376176071172e-10 191 57 14 0.245614035087719 0.0732984293193717
REAC REAC:R-HSA-877300 Interferon gamma signaling 2.78122712214288e-05 87 52 7 0.134615384615385 0.0804597701149425
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.00012672341286097 842 57 17 0.298245614035088 0.0201900237529691
REAC REAC:R-HSA-168256 Immune System 0.000323822756982865 2139 57 27 0.473684210526316 0.0126227208976157
REAC REAC:R-HSA-8983711 OAS antiviral response 0.000640847548618725 9 52 3 0.0576923076923077 0.333333333333333
REAC REAC:R-HSA-75158 TRAIL signaling 0.000689828717727814 8 64 3 0.046875 0.375
REAC REAC:R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes 0.00311607783862707 78 57 5 0.087719298245614 0.0641025641025641
REAC REAC:R-HSA-1500931 Cell-Cell communication 0.00332799693650924 127 59 6 0.101694915254237 0.047244094488189
REAC REAC:R-HSA-9637690 Response of Mtb to phagocytosis 0.00526455011359088 23 122 4 0.0327868852459016 0.173913043478261
REAC REAC:R-HSA-446728 Cell junction organization 0.00558244703016058 91 59 5 0.0847457627118644 0.0549450549450549
REAC REAC:R-HSA-9635486 Infection with Mycobacterium tuberculosis 0.00806344472464619 27 122 4 0.0327868852459016 0.148148148148148
REAC REAC:R-HSA-73887 Death Receptor Signalling 0.00915873435294098 140 26 4 0.153846153846154 0.0285714285714286
REAC REAC:R-HSA-9637687 Suppression of phagosomal maturation 0.00965108224552673 13 122 3 0.0245901639344262 0.230769230769231
REAC REAC:R-HSA-421270 Cell-cell junction organization 0.0100402813098452 64 59 4 0.0677966101694915 0.0625
REAC REAC:R-HSA-111465 Apoptotic cleavage of cellular proteins 0.0160396125062737 37 51 3 0.0588235294117647 0.0810810810810811
REAC REAC:R-HSA-5357801 Programmed Cell Death 0.0277474785797869 177 51 5 0.0980392156862745 0.0282485875706215
REAC REAC:R-HSA-75153 Apoptotic execution phase 0.0301158614053813 51 51 3 0.0588235294117647 0.0588235294117647
REAC REAC:R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 0.0320908899165758 63 91 4 0.043956043956044 0.0634920634920635
REAC REAC:R-HSA-1483191 Synthesis of PC 0.0412199639840413 28 110 3 0.0272727272727273 0.107142857142857
TF TF:M11679 Factor: IRF-7; motif: NCGAAANCGAAANYN 8.57486910647012e-12 622 77 22 0.285714285714286 0.0353697749196141
TF TF:M11670 Factor: IRF-5; motif: NYGAAACCGAAACY 6.23338012347203e-11 871 86 25 0.290697674418605 0.0287026406429392
TF TF:M07045 Factor: IRF-1; motif: NNRAAANNGAAASN 6.23338012347203e-11 535 101 22 0.217821782178218 0.0411214953271028
TF TF:M11671 Factor: IRF-5; motif: NCGAAACCGAAACY 6.27700605508367e-11 389 138 22 0.159420289855072 0.0565552699228792
TF TF:M07216 Factor: IRF1; motif: NNNYASTTTCACTTTCNNTTT 1.00863033138737e-10 440 101 20 0.198019801980198 0.0454545454545455
TF TF:M11664 Factor: IRF-2; motif: NGAAASYGAAAS 1.23242393487037e-10 1651 91 33 0.362637362637363 0.0199878861296184
TF TF:M04788 Factor: IRF-1; motif: STTTCACTTTCNNT 2.8485025508479e-10 536 101 21 0.207920792079208 0.0391791044776119
TF TF:M04020_1 Factor: IRF8; motif: NCGAAACCGAAACT; match class: 1 3.99335145200825e-10 45 91 9 0.0989010989010989 0.2
TF TF:M09957 Factor: IRF-2; motif: NAAANNGAAAGTGAAASTRN 4.48772162837157e-10 272 101 16 0.158415841584158 0.0588235294117647
TF TF:M11670_1 Factor: IRF-5; motif: NYGAAACCGAAACY; match class: 1 6.15092666176214e-10 36 77 8 0.103896103896104 0.222222222222222
TF TF:M04014 Factor: IRF3; motif: NNRRAANGGAAACCGAAACYR 6.15092666176214e-10 278 71 14 0.197183098591549 0.0503597122302158
TF TF:M04020 Factor: IRF8; motif: NCGAAACCGAAACT 9.31568824780027e-10 992 91 25 0.274725274725275 0.0252016129032258
TF TF:M11683_1 Factor: IRF-8; motif: NCGAAACCGAAACYN; match class: 1 1.10354952205804e-09 814 101 24 0.237623762376238 0.0294840294840295
TF TF:M11685 Factor: IRF-8; motif: NCGAAACYGAAACYN 1.15338667055972e-09 1617 91 31 0.340659340659341 0.0191713048855906
TF TF:M09733_1 Factor: STAT2; motif: NRGAAANNGAAACTNA; match class: 1 2.23840208874133e-09 367 101 17 0.168316831683168 0.0463215258855586
TF TF:M08775_1 Factor: IRF-2; motif: NAANYGAAASYR; match class: 1 2.28759534879417e-09 2761 92 40 0.434782608695652 0.0144875045273452
TF TF:M04015 Factor: IRF-4; motif: NCGAAACCGAAACYA 2.38104010114762e-09 2038 86 33 0.383720930232558 0.0161923454367027
TF TF:M08887 Factor: IRF; motif: NNGAAANTGAAANN 3.23631347065381e-09 1267 91 27 0.296703296703297 0.021310181531176
TF TF:M00453_1 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN; match class: 1 4.38018911856752e-09 332 101 16 0.158415841584158 0.0481927710843374
TF TF:M11665 Factor: IRF-2; motif: NGAAASYGAAAS 6.54963192219149e-09 2396 86 35 0.406976744186047 0.0146076794657763
TF TF:M11684_1 Factor: IRF-8; motif: NYGAAACYGAAACTN; match class: 1 1.55027477267647e-08 832 78 20 0.256410256410256 0.0240384615384615
TF TF:M11681 Factor: IRF-9; motif: NCGAAACYGAAACYN 2.22750626058771e-08 97 138 11 0.0797101449275362 0.11340206185567
TF TF:M09956 Factor: IRF-1; motif: NAAANNGAAASTGAAASNRN 2.22750626058771e-08 317 101 15 0.148514851485149 0.0473186119873817
TF TF:M11680 Factor: IRF-9; motif: NYGAAACYGAAACYN 2.74735349576761e-08 128 138 12 0.0869565217391304 0.09375
TF TF:M11664_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 3.73726438160813e-08 140 101 11 0.108910891089109 0.0785714285714286
TF TF:M04016 Factor: IRF5; motif: CCGAAACCGAAACY 4.49683816332102e-08 314 91 14 0.153846153846154 0.0445859872611465
TF TF:M11687_1 Factor: IRF-4; motif: NCGAAACCGAAACYN; match class: 1 6.77342945698144e-08 474 101 17 0.168316831683168 0.0358649789029536
TF TF:M04018 Factor: IRF7; motif: NCGAAARYGAAANT 7.19459781898498e-08 619 101 19 0.188118811881188 0.0306946688206785
TF TF:M04015_1 Factor: IRF-4; motif: NCGAAACCGAAACYA; match class: 1 9.52199274301564e-08 158 99 11 0.111111111111111 0.069620253164557
TF TF:M11685_1 Factor: IRF-8; motif: NCGAAACYGAAACYN; match class: 1 1.96274200178742e-07 118 78 9 0.115384615384615 0.076271186440678
TF TF:M10080 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN 1.96274200178742e-07 356 91 14 0.153846153846154 0.0393258426966292
TF TF:M00772 Factor: IRF; motif: RRAANTGAAASYGNV 5.44246458284912e-07 1029 57 17 0.298245614035088 0.0165208940719145
TF TF:M11665_1 Factor: IRF-2; motif: NGAAASYGAAAS; match class: 1 6.71272120864887e-07 246 78 11 0.141025641025641 0.0447154471544715
TF TF:M08887_1 Factor: IRF; motif: NNGAAANTGAAANN; match class: 1 7.0123210494717e-07 73 101 8 0.0792079207920792 0.10958904109589
TF TF:M11686 Factor: IRF-4; motif: NYGAAASYGAAACYN 8.69847807443993e-07 3391 86 38 0.441860465116279 0.0112061338838101
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 9.13863357739429e-07 3082 86 36 0.418604651162791 0.0116807268007787
TF TF:M04017 Factor: IRF5; motif: NACCGAAACYA 1.44448863365476e-06 195 82 10 0.121951219512195 0.0512820512820513
TF TF:M11672 Factor: IRF-5; motif: NCGAAACCGAAACY 2.10293756800812e-06 120 138 10 0.072463768115942 0.0833333333333333
TF TF:M09733 Factor: STAT2; motif: NRGAAANNGAAACTNA 2.21788795673819e-06 2842 91 35 0.384615384615385 0.0123152709359606
TF TF:M00972 Factor: IRF; motif: RAAANTGAAAN 3.12914201210034e-06 1979 54 21 0.388888888888889 0.010611419909045
TF TF:M11682_1 Factor: IRF-8; motif: NYGAAASYGAAACYN; match class: 1 3.9423981843089e-06 543 78 14 0.179487179487179 0.0257826887661142
TF TF:M08775 Factor: IRF-2; motif: NAANYGAAASYR 5.66677227453288e-06 8370 99 69 0.696969696969697 0.00824372759856631
TF TF:M11687 Factor: IRF-4; motif: NCGAAACCGAAACYN 1.31727720777008e-05 3595 86 37 0.430232558139535 0.0102920723226704
TF TF:M11682 Factor: IRF-8; motif: NYGAAASYGAAACYN 1.60671476661708e-05 3795 86 38 0.441860465116279 0.0100131752305665
TF TF:M09629 Factor: IRF-1; motif: NAAANNGAAAGTGAAASTRN 2.19079825369462e-05 336 101 12 0.118811881188119 0.0357142857142857
TF TF:M11686_1 Factor: IRF-4; motif: NYGAAASYGAAACYN; match class: 1 2.85120529664082e-05 452 78 12 0.153846153846154 0.0265486725663717
TF TF:M00699 Factor: ICSBP; motif: RAARTGAAACTG 3.17532398846673e-05 1184 140 26 0.185714285714286 0.0219594594594595
TF TF:M07323 Factor: IRF-4; motif: KRAAMNGAAANYN 3.17532398846673e-05 938 91 18 0.197802197802198 0.0191897654584222
TF TF:M00772_1 Factor: IRF; motif: RRAANTGAAASYGNV; match class: 1 6.0845972434035e-05 57 101 6 0.0594059405940594 0.105263157894737
TF TF:M11677 Factor: IRF-3; motif: NGGAAACNGAAACCGAAACN 0.000107385036732234 470 101 13 0.128712871287129 0.0276595744680851
TF TF:M00699_1 Factor: ICSBP; motif: RAARTGAAACTG; match class: 1 0.00011440662209681 47 138 6 0.0434782608695652 0.127659574468085
TF TF:M11683 Factor: IRF-8; motif: NCGAAACCGAAACYN 0.000132880657408611 4690 83 40 0.481927710843373 0.00852878464818763
TF TF:M04788_1 Factor: IRF-1; motif: STTTCACTTTCNNT; match class: 1 0.000180694135930944 17 101 4 0.0396039603960396 0.235294117647059
TF TF:M11671_1 Factor: IRF-5; motif: NCGAAACCGAAACY; match class: 1 0.000263368507871287 14 138 4 0.0289855072463768 0.285714285714286
TF TF:M08295_1 Factor: FOXO1A:Elf-1; motif: NAGAAAACCGAANM; match class: 1 0.000285693299051567 4997 78 39 0.5 0.00780468280968581
TF TF:M11673 Factor: IRF-5; motif: NCGAAACCGAAACY 0.000291029247657231 57 75 5 0.0666666666666667 0.087719298245614
TF TF:M11684 Factor: IRF-8; motif: NYGAAACYGAAACTN 0.000314187370765371 4664 83 39 0.469879518072289 0.00836192109777015
TF TF:M01224 Factor: P50:RELA-P65; motif: GGANTTYCCCWN 0.000340664849876118 2329 85 26 0.305882352941176 0.0111635895234006
TF TF:M09958 Factor: IRF-3; motif: RAAARGGAAANNGAAASNGA 0.000411899872227332 589 66 11 0.166666666666667 0.0186757215619694
TF TF:M01882 Factor: IRF-2; motif: NNRAAAGTGAAASNNA 0.000778674129891743 258 101 9 0.0891089108910891 0.0348837209302326
TF TF:M04802 Factor: c-Fos; motif: ACTCACCA 0.00102150993777576 7386 18 16 0.888888888888889 0.00216626049282426
TF TF:M00258 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC 0.00103773031905806 823 145 19 0.131034482758621 0.023086269744836
TF TF:M11676 Factor: IRF-3; motif: NGGAAANGGAAASNGAAACN 0.00107568006098896 562 91 12 0.131868131868132 0.0213523131672598
TF TF:M11679_1 Factor: IRF-7; motif: NCGAAANCGAAANYN; match class: 1 0.00187188984695255 23 138 4 0.0289855072463768 0.173913043478261
TF TF:M04018_1 Factor: IRF7; motif: NCGAAARYGAAANT; match class: 1 0.00190332599308372 24 43 3 0.0697674418604651 0.125
TF TF:M00972_1 Factor: IRF; motif: RAAANTGAAAN; match class: 1 0.00197911056616013 205 54 6 0.111111111111111 0.0292682926829268
TF TF:M07379 Factor: c-Ets-2; motif: NNCTTCCTNNN 0.0028707051740958 3487 52 22 0.423076923076923 0.00630914826498423
TF TF:M07323_1 Factor: IRF-4; motif: KRAAMNGAAANYN; match class: 1 0.00296377358636419 39 91 4 0.043956043956044 0.102564102564103
TF TF:M11423 Factor: Erm; motif: RSAGGAAGGAAGTN 0.00315899784900285 4841 25 16 0.64 0.00330510225160091
TF TF:M10080_1 Factor: STAT2; motif: RRGRAANNGAAACTGAAAN; match class: 1 0.00369037549571822 11 125 3 0.024 0.272727272727273
TF TF:M00258_1 Factor: ISGF-3; motif: CAGTTTCWCTTTYCC; match class: 1 0.00495752829009161 30 138 4 0.0289855072463768 0.133333333333333
TF TF:M08630 Factor: TEF-3:CLOCK; motif: RCACGTGYNNNNRCATWCY 0.00649735745751227 171 117 7 0.0598290598290598 0.0409356725146199
TF TF:M08233 Factor: ERF:C/EBPdelta; motif: NNCGGAWRTTGCGCAAY 0.00732107752620612 5782 117 54 0.461538461538462 0.00933932895191975
TF TF:M01199 Factor: RNF96; motif: BCCCGCRGCC 0.00881555423245446 8473 145 85 0.586206896551724 0.0100318659270624
TF TF:M07045_1 Factor: IRF-1; motif: NNRAAANNGAAASN; match class: 1 0.010236478901944 19 101 3 0.0297029702970297 0.157894736842105
TF TF:M11678 Factor: IRF-7; motif: NNGAAAGTGAAANTR 0.0109084867999722 179 54 5 0.0925925925925926 0.0279329608938547
TF TF:M11223 Factor: CREB1; motif: NRTGACGTCANN 0.0118944837539387 2810 97 28 0.288659793814433 0.0099644128113879
TF TF:M07040 Factor: GKLF; motif: NNRRGRRNGNSNNN 0.0118944837539387 12705 145 114 0.786206896551724 0.0089728453364817
TF TF:M10583 Factor: Barhl2; motif: NTAATTGN 0.0121545718787521 1104 16 6 0.375 0.00543478260869565
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0133805116612395 5919 144 64 0.444444444444444 0.0108126372698091
TF TF:M04249 Factor: FOXJ3; motif: RTAAACAA 0.0137722934897725 3888 106 37 0.349056603773585 0.00951646090534979
TF TF:M08215 Factor: Elk-1:EVX1; motif: NNCGGWAATNNYMATTA 0.0214710768828387 6557 15 12 0.8 0.00183010523105079
TF TF:M10579 Factor: Barhl-1; motif: NTAANNGN 0.0226730685046572 1574 18 7 0.388888888888889 0.00444726810673443
TF TF:M11889 Factor: Pax-4a; motif: TNACGCTAATTAR 0.0232966910805178 739 17 5 0.294117647058824 0.006765899864682
TF TF:M09902 Factor: ESE-1; motif: NNANVAGGAAGTNN 0.0232966910805178 3200 52 19 0.365384615384615 0.0059375
TF TF:M07087_1 Factor: Elf-1; motif: NRANCMGGAAGTG; match class: 1 0.0241855011919859 155 42 4 0.0952380952380952 0.0258064516129032
TF TF:M01219 Factor: SP1:SP3; motif: CCSCCCCCYCC 0.0244561433980674 6812 144 70 0.486111111111111 0.0102759835584263
TF TF:M01400 Factor: Dlx-3; motif: NNNNNATAATTACMNNN 0.0257601051571711 3276 16 9 0.5625 0.00274725274725275
TF TF:M01438 Factor: ipf1; motif: NNRNTAATTAGYNCAN 0.0267611358620259 3325 13 8 0.615384615384615 0.00240601503759398
TF TF:M02278_1 Factor: SPI1; motif: AGGAAGT; match class: 1 0.026787399284123 1496 52 12 0.230769230769231 0.00802139037433155
TF TF:M03579_1 Factor: PEA3; motif: AGGAAGT; match class: 1 0.026787399284123 1496 52 12 0.230769230769231 0.00802139037433155
TF TF:M06273 Factor: ZNF766; motif: KGTGCGGKCCGA 0.026787399284123 51 56 3 0.0535714285714286 0.0588235294117647
TF TF:M07382_1 Factor: Fli-1; motif: MGGAAGT; match class: 1 0.026787399284123 1496 52 12 0.230769230769231 0.00802139037433155
TF TF:M08458_1 Factor: Erm:C/EBPdelta; motif: RSCGGAWRTTGCGYAAY; match class: 1 0.026787399284123 3168 83 26 0.313253012048193 0.00820707070707071
TF TF:M01870_1 Factor: C-ets-1; motif: AGGAAGN; match class: 1 0.026787399284123 1496 52 12 0.230769230769231 0.00802139037433155
TF TF:M01665 Factor: IRF-8; motif: AGTTTCW 0.026787399284123 4771 46 22 0.478260869565217 0.0046111926220918
TF TF:M11361_1 Factor: c-MAF; motif: NTGCTGASTCAGCAN; match class: 1 0.026787399284123 268 11 3 0.272727272727273 0.0111940298507463
TF TF:M00771_1 Factor: Ets; motif: ANNCACTTCCTG; match class: 1 0.0277625913914617 445 61 7 0.114754098360656 0.0157303370786517
TF TF:M01002 Factor: DEAF1; motif: RNNNRTTCGGGNRTTTCCGGRRNKN 0.0292038759559599 1086 113 16 0.141592920353982 0.0147329650092081
TF TF:M00472 Factor: FOXO4; motif: RWAAACAANNN 0.0295971828582889 940 143 17 0.118881118881119 0.0180851063829787
TF TF:M07329_1 Factor: Osx; motif: CCNCCCCCNNN; match class: 1 0.0310451690711524 2509 144 33 0.229166666666667 0.0131526504583499
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.0323211092761643 4199 144 48 0.333333333333333 0.0114312931650393
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.0335037703686906 10357 145 96 0.662068965517241 0.00926909336680506
TF TF:M04849 Factor: RelA-p65; motif: AAASTCCC 0.0335037703686906 6240 42 24 0.571428571428571 0.00384615384615385
TF TF:M09843_1 Factor: GABPBETA; motif: YCACTTCCKGN; match class: 1 0.0344307905646726 215 94 6 0.0638297872340425 0.027906976744186
TF TF:M09659 Factor: PU.1; motif: NRAAAGAGGAAGTGARA 0.0350031005850671 2523 17 8 0.470588235294118 0.00317082837891399
TF TF:M04300 Factor: Dlx-2; motif: NYAATTAN 0.0353709384611895 5422 18 12 0.666666666666667 0.00221320545924013
TF TF:M04613 Factor: HLTF; motif: AGSCARAAAGYRGSTGS 0.0386548907143447 8006 24 18 0.75 0.00224831376467649
TF TF:M08369_1 Factor: HOXD12:PEA3; motif: RCCGGAAGTAATAAAM; match class: 1 0.0394903148833447 657 6 3 0.5 0.0045662100456621
TF TF:M08881_1 Factor: ETSLIKE; motif: NACTTCCTNN; match class: 1 0.0395034959465952 298 47 5 0.106382978723404 0.0167785234899329
TF TF:M01279_1 Factor: IRF-3; motif: NBNBTTTCSCTTT; match class: 1 0.0395034959465952 101 78 4 0.0512820512820513 0.0396039603960396
TF TF:M12227_1 Factor: ZIC4; motif: NNCCNCCCRYNGYGN; match class: 1 0.0400163772568433 5898 115 51 0.443478260869565 0.008646998982706
TF TF:M11886 Factor: Pax-4a; motif: TYACGCTAATTAN 0.0400163772568433 1284 55 11 0.2 0.00856697819314642
TF TF:M09887_1 Factor: CREB1; motif: NRRTGACGTMA; match class: 1 0.0400163772568433 1616 96 18 0.1875 0.0111386138613861
TF TF:M07289 Factor: GKLF; motif: NNNRGGNGNGGSN 0.0401590873978831 14646 145 124 0.855172413793103 0.0084664754881879
TF TF:M07063_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0401590873978831 3495 112 34 0.303571428571429 0.00972818311874106
TF TF:M10435_1 Factor: Sp2; motif: GGGGCGGGG; match class: 1 0.0401590873978831 3495 112 34 0.303571428571429 0.00972818311874106
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.040201619975084 6225 115 53 0.460869565217391 0.0085140562248996
TF TF:M11515 Factor: DMRT1; motif: NNNNGCTACATN 0.040201619975084 3857 18 10 0.555555555555556 0.00259268861809697
TF TF:M10073_1 Factor: PU.1; motif: NRAAAGAGGAAGTGRNN; match class: 1 0.040201619975084 177 46 4 0.0869565217391304 0.0225988700564972
TF TF:M05916 Factor: ZNF407; motif: NGGTGAAARARC 0.0402738498733305 124 114 5 0.043859649122807 0.0403225806451613
TF TF:M11225 Factor: CREM; motif: NNTGACGTCANN 0.0404253712577048 2710 100 26 0.26 0.00959409594095941
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0404253712577048 16384 137 127 0.927007299270073 0.00775146484375
TF TF:M00746 Factor: Elf-1; motif: RNWMBAGGAART 0.0404253712577048 3365 17 9 0.529411764705882 0.00267459138187221
TF TF:M11321_1 Factor: C/EBPdelta; motif: NRTTGCGYAAYN; match class: 1 0.0404253712577048 1852 52 13 0.25 0.00701943844492441
TF TF:M04855 Factor: IRF-4; motif: AAGTTTC 0.0404253712577048 7694 128 68 0.53125 0.00883805562776189
TF TF:M00155 Factor: ARP-1; motif: TGARCCYTTGAMCCCW 0.0404253712577048 5581 18 12 0.666666666666667 0.00215015230245476
TF TF:M10772 Factor: hoxd9; motif: GYMATAAAAN 0.0404253712577048 1696 10 5 0.5 0.00294811320754717
TF TF:M09998 Factor: NeuroD-2; motif: RRCAGATGG 0.0414185495611373 321 12 3 0.25 0.00934579439252336
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.0416529087546169 10023 114 75 0.657894736842105 0.0074827895839569
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0426564942279197 6260 144 64 0.444444444444444 0.010223642172524
TF TF:M09877 Factor: BMAL1; motif: NSCACGTGNSN 0.0426564942279197 2189 123 26 0.211382113821138 0.0118775696665144
TF TF:M03563 Factor: RelA-p65; motif: GGGANTTTCCNN 0.0426564942279197 4643 97 37 0.381443298969072 0.00796898556967478
TF TF:M11614 Factor: TCF-3; motif: ACATCGRGRCGCTGW 0.0426564942279197 52 72 3 0.0416666666666667 0.0576923076923077
TF TF:M05327_1 Factor: WT1; motif: NGCGGGGGGGTSMMCYN; match class: 1 0.0426564942279197 1757 144 25 0.173611111111111 0.0142287990893569
TF TF:M12166_1 Factor: CPBP; motif: NGCCACGCCCN; match class: 1 0.0426671575753329 162 136 6 0.0441176470588235 0.037037037037037
TF TF:M04012 Factor: HSFY1; motif: TTTCGAACG 0.0427720328012983 1013 141 17 0.120567375886525 0.016781836130306
TF TF:M01137 Factor: FOXO3A; motif: TRTAAACAANWN 0.0428292547953312 3880 99 33 0.333333333333333 0.00850515463917526
TF TF:M01388_1 Factor: Dlx-5; motif: NNRGYAATTRNYKNNN; match class: 1 0.044133777376059 5764 20 13 0.65 0.00225537820957668
TF TF:M11223_1 Factor: CREB1; motif: NRTGACGTCANN; match class: 1 0.044133777376059 2678 97 25 0.257731958762887 0.00933532486930545
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0453631203731841 7710 144 75 0.520833333333333 0.00972762645914397
TF TF:M11361 Factor: c-MAF; motif: NTGCTGASTCAGCAN 0.0453631203731841 378 11 3 0.272727272727273 0.00793650793650794
TF TF:M11469 Factor: PDEF; motif: NANCAGGATGYN 0.0453631203731841 525 44 6 0.136363636363636 0.0114285714285714
TF TF:M00173 Factor: AP-1; motif: RSTGACTNANW 0.0453631203731841 2737 127 31 0.244094488188976 0.0113262696382901
TF TF:M07221 Factor: NF-kappaB1; motif: KGGRNTTTCCM 0.0467468053880918 2417 52 15 0.288461538461538 0.00620604054613157
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.0469122066047179 6047 144 62 0.430555555555556 0.0102530180254672
TF TF:M11000 Factor: LIM-1; motif: NYAATTAN 0.0481601227584737 5830 18 12 0.666666666666667 0.00205831903945111
TF TF:M04405 Factor: Msx-1; motif: NCAATTAN 0.0481601227584737 614 16 4 0.25 0.00651465798045603
TF TF:M08824 Factor: NET; motif: CMGGAARTR 0.0481601227584737 1028 52 9 0.173076923076923 0.00875486381322957
TF TF:M01870 Factor: C-ets-1; motif: AGGAAGN 0.0481601227584737 6837 54 30 0.555555555555556 0.00438788942518649
TF TF:M00208 Factor: NF-kappaB; motif: NGGGACTTTCCA 0.0481601227584737 3757 145 43 0.296551724137931 0.0114453021027415
TF TF:M03579 Factor: PEA3; motif: AGGAAGT 0.0481601227584737 6837 54 30 0.555555555555556 0.00438788942518649
TF TF:M00205_1 Factor: GR; motif: GGTACAANNTGTYCTK; match class: 1 0.0481601227584737 1482 12 5 0.416666666666667 0.00337381916329285
TF TF:M10884 Factor: PRX-2; motif: NCAATTAN 0.0481601227584737 2080 43 12 0.27906976744186 0.00576923076923077
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.0481601227584737 3783 103 33 0.320388349514563 0.00872323552735924
TF TF:M02278 Factor: SPI1; motif: AGGAAGT 0.0481601227584737 6837 54 30 0.555555555555556 0.00438788942518649
TF TF:M00678 Factor: Tel-2; motif: YTACTTCCTG 0.0481601227584737 5292 76 33 0.434210526315789 0.00623582766439909
TF TF:M04636_1 Factor: TFII-I; motif: NAGGAAGTGN; match class: 1 0.0481601227584737 5733 84 38 0.452380952380952 0.00662829234257806
TF TF:M07436 Factor: WT1; motif: NNGGGNGGGSGN 0.0481601227584737 6182 144 63 0.4375 0.0101908767389194
TF TF:M10893 Factor: PMX2B; motif: NCAATTAN 0.0481601227584737 2080 43 12 0.27906976744186 0.00576923076923077
TF TF:M11386 Factor: elf5; motif: AANNAGGAAGTR 0.0481601227584737 678 91 10 0.10989010989011 0.0147492625368732
TF TF:M10894 Factor: PMX2B; motif: NYAATTAS 0.0481601227584737 2080 43 12 0.27906976744186 0.00576923076923077
TF TF:M04318 Factor: EN2; motif: NNYAATTANN 0.0481601227584737 1982 18 7 0.388888888888889 0.00353178607467205
TF TF:M11579 Factor: foxl2; motif: NNYGTAAACAN 0.0481601227584737 5888 51 26 0.509803921568627 0.00441576086956522
TF TF:M10571 Factor: Gbx2; motif: NYAATTAN 0.0481601227584737 614 16 4 0.25 0.00651465798045603
TF TF:M11668 Factor: IRF-6; motif: ACCGATACC 0.0481601227584737 406 101 8 0.0792079207920792 0.0197044334975369
TF TF:M09955 Factor: HOXC9; motif: WTTTATKGCN 0.0481601227584737 1198 9 4 0.444444444444444 0.00333889816360601
TF TF:M10573 Factor: Gbx2; motif: NYAATTAN 0.0481601227584737 614 16 4 0.25 0.00651465798045603
TF TF:M07382 Factor: Fli-1; motif: MGGAAGT 0.0481601227584737 6837 54 30 0.555555555555556 0.00438788942518649
TF TF:M10574 Factor: Gbx2; motif: NYAATTAN 0.0481601227584737 614 16 4 0.25 0.00651465798045603
TF TF:M07379_1 Factor: c-Ets-2; motif: NNCTTCCTNNN; match class: 1 0.0481601227584737 362 12 3 0.25 0.00828729281767956
TF TF:M00423 Factor: FOXJ2; motif: AYMATAATATTTKN 0.0481601227584737 6970 73 39 0.534246575342466 0.00559540889526542
TF TF:M00339_1 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS; match class: 1 0.0481601227584737 1466 52 11 0.211538461538462 0.00750341064120055
TF TF:M10860 Factor: En-1; motif: NYAATTAN 0.0481601227584737 614 16 4 0.25 0.00651465798045603
TF TF:M00339 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS 0.0481601227584737 6806 54 30 0.555555555555556 0.00440787540405525
TF TF:M09907_1 Factor: Erg; motif: NRRSAGGAAGNGG; match class: 1 0.0481601227584737 5070 135 51 0.377777777777778 0.0100591715976331
TF TF:M04706_1 Factor: RelA; motif: GGGRAWTYC; match class: 1 0.0487697957483278 344 122 8 0.0655737704918033 0.0232558139534884
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.0492992599730128 8180 144 78 0.541666666666667 0.00953545232273839
TF TF:M01279 Factor: IRF-3; motif: NBNBTTTCSCTTT 0.0494255865079723 1647 54 12 0.222222222222222 0.00728597449908925
WP WP:WP4197 The human immune response to tuberculosis 0.00392298898762581 23 54 4 0.0740740740740741 0.173913043478261
WP WP:WP619 Type II interferon signaling (IFNG) 0.0146026148139455 37 55 4 0.0727272727272727 0.108108108108108
WP WP:WP254 Apoptosis 0.0489522681161468 86 36 4 0.111111111111111 0.0465116279069767

pEpi01 transcription factor target enrichment of top program genes

TF enrichment of pEpi01
Possible regulators of activation of pEpi01 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.