pMA01 program activity among Mast cells

Activation of pMA01
pMA01 gene program activation in Mast cells.
Gene program activation of pMA01 by different cell subtypes
pMA01 gene program activation among cells of different subtypes (Mast cells).

pMA01 top program genes

Top genes of pMA01 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pMA01 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pMA01
pMA01 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0010038 response to metal ion 1.38229701734752e-05 371 6 5 0.833333333333333 0.0134770889487871
GO:BP GO:0034645 cellular macromolecule biosynthetic process 1.38229701734752e-05 5051 49 32 0.653061224489796 0.00633537913284498
GO:BP GO:0014074 response to purine-containing compound 1.38229701734752e-05 152 6 4 0.666666666666667 0.0263157894736842
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 1.38229701734752e-05 1887 125 35 0.28 0.0185479597244303
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 1.38229701734752e-05 1197 49 16 0.326530612244898 0.0133667502088555
GO:BP GO:0046683 response to organophosphorus 1.38229701734752e-05 137 6 4 0.666666666666667 0.0291970802919708
GO:BP GO:0031960 response to corticosteroid 1.38229701734752e-05 165 24 6 0.25 0.0363636363636364
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 1.38229701734752e-05 4102 49 29 0.591836734693878 0.00706972208678693
GO:BP GO:1902893 regulation of pri-miRNA transcription by RNA polymerase II 1.38229701734752e-05 50 38 5 0.131578947368421 0.1
GO:BP GO:0061614 pri-miRNA transcription by RNA polymerase II 1.38229701734752e-05 51 38 5 0.131578947368421 0.0980392156862745
GO:BP GO:0051592 response to calcium ion 1.38229701734752e-05 151 6 4 0.666666666666667 0.0264900662251656
GO:BP GO:0051591 response to cAMP 1.38229701734752e-05 97 6 4 0.666666666666667 0.0412371134020619
GO:BP GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II 1.38229701734752e-05 40 38 5 0.131578947368421 0.125
GO:BP GO:0051254 positive regulation of RNA metabolic process 1.38229701734752e-05 1714 44 18 0.409090909090909 0.0105017502917153
GO:BP GO:2000112 regulation of cellular macromolecule biosynthetic process 1.38229701734752e-05 4071 49 29 0.591836734693878 0.00712355686563498
GO:BP GO:0009059 macromolecule biosynthetic process 1.38229701734752e-05 5114 49 32 0.653061224489796 0.00625733281188893
GO:BP GO:0031326 regulation of cellular biosynthetic process 1.78411881692479e-05 4273 49 29 0.591836734693878 0.00678680084249941
GO:BP GO:0051252 regulation of RNA metabolic process 1.78460088732888e-05 3822 51 28 0.549019607843137 0.00732600732600733
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 1.78460088732888e-05 1851 49 19 0.387755102040816 0.0102647217720151
GO:BP GO:0010467 gene expression 1.78460088732888e-05 6179 59 40 0.677966101694915 0.00647353940767114
GO:BP GO:0006366 transcription by RNA polymerase II 1.78460088732888e-05 2723 49 23 0.469387755102041 0.00844656628718325
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 1.78460088732888e-05 4091 51 29 0.568627450980392 0.0070887313615253
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 1.8691553162895e-05 5017 44 29 0.659090909090909 0.00578034682080925
GO:BP GO:0009889 regulation of biosynthetic process 2.02639908798745e-05 4361 49 29 0.591836734693878 0.0066498509516166
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 2.08291390603216e-05 2555 49 22 0.448979591836735 0.0086105675146771
GO:BP GO:0010035 response to inorganic substance 2.08291390603216e-05 575 6 5 0.833333333333333 0.00869565217391304
GO:BP GO:0071248 cellular response to metal ion 2.08291390603216e-05 192 6 4 0.666666666666667 0.0208333333333333
GO:BP GO:0016070 RNA metabolic process 2.18149485448601e-05 4710 116 56 0.482758620689655 0.0118895966029724
GO:BP GO:0014070 response to organic cyclic compound 2.93978496881053e-05 967 25 10 0.4 0.0103412616339193
GO:BP GO:0071241 cellular response to inorganic substance 3.14950700769533e-05 220 6 4 0.666666666666667 0.0181818181818182
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 3.24429154286477e-05 1967 49 19 0.387755102040816 0.00965937976614133
GO:BP GO:0048534 hematopoietic or lymphoid organ development 3.49006530716234e-05 966 38 12 0.315789473684211 0.0124223602484472
GO:BP GO:0071310 cellular response to organic substance 3.65508498282448e-05 2776 25 15 0.6 0.00540345821325648
GO:BP GO:0090304 nucleic acid metabolic process 3.65508498282448e-05 5226 62 37 0.596774193548387 0.00707998469192499
GO:BP GO:0034641 cellular nitrogen compound metabolic process 3.73054150463975e-05 6563 45 33 0.733333333333333 0.0050281883285083
GO:BP GO:0006351 transcription, DNA-templated 3.73054150463975e-05 3714 49 26 0.530612244897959 0.00700053850296177
GO:BP GO:0097659 nucleic acid-templated transcription 3.73054150463975e-05 3715 49 26 0.530612244897959 0.00699865410497981
GO:BP GO:0009891 positive regulation of biosynthetic process 3.73054150463975e-05 2004 49 19 0.387755102040816 0.0094810379241517
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 3.9457474317938e-05 1617 49 17 0.346938775510204 0.0105132962275819
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 3.9457474317938e-05 1618 49 17 0.346938775510204 0.0105067985166873
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 3.9457474317938e-05 1617 49 17 0.346938775510204 0.0105132962275819
GO:BP GO:0032774 RNA biosynthetic process 3.9457474317938e-05 3731 49 26 0.530612244897959 0.00696864111498258
GO:BP GO:0002520 immune system development 4.64644486683498e-05 1020 38 12 0.315789473684211 0.0117647058823529
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 5.1818182863546e-05 3535 49 25 0.510204081632653 0.00707213578500707
GO:BP GO:0006355 regulation of transcription, DNA-templated 5.1818182863546e-05 3534 49 25 0.510204081632653 0.00707413695529145
GO:BP GO:2001141 regulation of RNA biosynthetic process 5.21154597096179e-05 3540 49 25 0.510204081632653 0.00706214689265537
GO:BP GO:0051384 response to glucocorticoid 5.28408623008819e-05 146 10 4 0.4 0.0273972602739726
GO:BP GO:0010033 response to organic substance 5.50092242582641e-05 3412 25 16 0.64 0.00468933177022274
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 8.39513503678418e-05 4199 49 27 0.551020408163265 0.0064301024053346
GO:BP GO:0070887 cellular response to chemical stimulus 8.90119797479401e-05 3393 49 24 0.489795918367347 0.00707338638373121
GO:BP GO:0051253 negative regulation of RNA metabolic process 8.90119797479401e-05 1445 125 27 0.216 0.0186851211072664
GO:BP GO:0010468 regulation of gene expression 8.90119797479401e-05 5196 44 28 0.636363636363636 0.00538876058506543
GO:BP GO:1903312 negative regulation of mRNA metabolic process 9.89137066383494e-05 91 73 6 0.0821917808219178 0.0659340659340659
GO:BP GO:0044249 cellular biosynthetic process 9.89137066383494e-05 6154 49 33 0.673469387755102 0.00536236594085148
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 9.89137066383494e-05 1548 125 28 0.224 0.0180878552971576
GO:BP GO:0071277 cellular response to calcium ion 9.89137066383494e-05 84 6 3 0.5 0.0357142857142857
GO:BP GO:0030099 myeloid cell differentiation 9.89137066383494e-05 428 37 8 0.216216216216216 0.0186915887850467
GO:BP GO:0018130 heterocycle biosynthetic process 9.89137066383494e-05 4269 29 19 0.655172413793103 0.00445069102834387
GO:BP GO:0019438 aromatic compound biosynthetic process 9.89137066383494e-05 4278 29 19 0.655172413793103 0.00444132772323516
GO:BP GO:0030097 hemopoiesis 0.000102017369763573 928 38 11 0.289473684210526 0.0118534482758621
GO:BP GO:1901576 organic substance biosynthetic process 0.000135402958916709 6248 49 33 0.673469387755102 0.00528169014084507
GO:BP GO:0051726 regulation of cell cycle 0.000151308910933652 1236 49 14 0.285714285714286 0.0113268608414239
GO:BP GO:0010941 regulation of cell death 0.000160065390641296 1720 63 19 0.301587301587302 0.011046511627907
GO:BP GO:0042981 regulation of apoptotic process 0.000160065390641296 1549 63 18 0.285714285714286 0.0116204002582311
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.000160065390641296 5848 67 40 0.597014925373134 0.00683994528043776
GO:BP GO:1901362 organic cyclic compound biosynthetic process 0.000160065390641296 4439 29 19 0.655172413793103 0.0042802432980401
GO:BP GO:0001568 blood vessel development 0.000169146545558699 792 38 10 0.263157894736842 0.0126262626262626
GO:BP GO:1901654 response to ketone 0.000172604932625431 204 38 6 0.157894736842105 0.0294117647058824
GO:BP GO:0009058 biosynthetic process 0.000172604932625431 6340 49 33 0.673469387755102 0.00520504731861199
GO:BP GO:0009628 response to abiotic stimulus 0.000190381639624564 1261 12 7 0.583333333333333 0.00555114988104679
GO:BP GO:0043067 regulation of programmed cell death 0.000190381639624564 1582 63 18 0.285714285714286 0.011378002528445
GO:BP GO:0009719 response to endogenous stimulus 0.000190462361124906 1683 13 8 0.615384615384615 0.0047534165181224
GO:BP GO:2000113 negative regulation of cellular macromolecule biosynthetic process 0.000191920306273969 1628 125 28 0.224 0.0171990171990172
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.000194039568217134 3083 125 42 0.336 0.0136230943885825
GO:BP GO:0048545 response to steroid hormone 0.00019617935360424 349 24 6 0.25 0.0171919770773639
GO:BP GO:0006139 nucleobase-containing compound metabolic process 0.000202469214177613 5746 62 37 0.596774193548387 0.00643926209537069
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 0.000207080833906775 1639 125 28 0.224 0.0170835875533862
GO:BP GO:0001944 vasculature development 0.000217493545471403 830 38 10 0.263157894736842 0.0120481927710843
GO:BP GO:0033993 response to lipid 0.000231679911229676 918 28 9 0.321428571428571 0.00980392156862745
GO:BP GO:0002573 myeloid leukocyte differentiation 0.000238017484110183 213 4 3 0.75 0.0140845070422535
GO:BP GO:0080090 regulation of primary metabolic process 0.000251407275900698 6053 73 43 0.589041095890411 0.00710391541384437
GO:BP GO:0006915 apoptotic process 0.000274536724840683 1990 63 20 0.317460317460317 0.0100502512562814
GO:BP GO:1901700 response to oxygen-containing compound 0.000278331707718419 1739 25 11 0.44 0.00632547441058079
GO:BP GO:1901216 positive regulation of neuron death 0.00030082393671925 98 8 3 0.375 0.0306122448979592
GO:BP GO:0008219 cell death 0.000317207418353687 2292 14 9 0.642857142857143 0.00392670157068063
GO:BP GO:0034097 response to cytokine 0.000324954110664676 1226 47 13 0.276595744680851 0.0106035889070147
GO:BP GO:0071495 cellular response to endogenous stimulus 0.000324954110664676 1422 25 10 0.4 0.0070323488045007
GO:BP GO:0046483 heterocycle metabolic process 0.000351483122461971 5904 62 37 0.596774193548387 0.00626693766937669
GO:BP GO:0043009 chordate embryonic development 0.000361178807970907 616 65 11 0.169230769230769 0.0178571428571429
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 0.000378041640368647 1707 125 28 0.224 0.0164030462800234
GO:BP GO:0034405 response to fluid shear stress 0.000396272681620379 37 71 4 0.0563380281690141 0.108108108108108
GO:BP GO:0051385 response to mineralocorticoid 0.000396272681620379 35 24 3 0.125 0.0857142857142857
GO:BP GO:0006725 cellular aromatic compound metabolic process 0.000396272681620379 5956 62 37 0.596774193548387 0.00621222296843519
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.000396272681620379 1339 125 24 0.192 0.0179238237490665
GO:BP GO:0048514 blood vessel morphogenesis 0.000396272681620379 711 38 9 0.236842105263158 0.0126582278481013
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.000396272681620379 1337 125 24 0.192 0.0179506357516829
GO:BP GO:0048872 homeostasis of number of cells 0.000401239169442457 261 37 6 0.162162162162162 0.0229885057471264
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.000401239169442457 1341 125 24 0.192 0.0178970917225951
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 0.000415437895948473 901 47 11 0.234042553191489 0.0122086570477248
GO:BP GO:0009792 embryo development ending in birth or egg hatching 0.000415437895948473 635 65 11 0.169230769230769 0.0173228346456693
GO:BP GO:0072359 circulatory system development 0.000415437895948473 1194 43 12 0.27906976744186 0.0100502512562814
GO:BP GO:0032870 cellular response to hormone stimulus 0.000415437895948473 645 24 7 0.291666666666667 0.0108527131782946
GO:BP GO:0009725 response to hormone 0.000435292868979789 921 24 8 0.333333333333333 0.00868621064060804
GO:BP GO:0009890 negative regulation of biosynthetic process 0.000459423396372639 1740 125 28 0.224 0.0160919540229885
GO:BP GO:0035239 tube morphogenesis 0.000514403153413392 950 38 10 0.263157894736842 0.0105263157894737
GO:BP GO:1901701 cellular response to oxygen-containing compound 0.000581693549987303 1227 25 9 0.36 0.00733496332518337
GO:BP GO:0000302 response to reactive oxygen species 0.000581693549987303 237 5 3 0.6 0.0126582278481013
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.000581693549987303 3274 121 41 0.338842975206612 0.0125229077580941
GO:BP GO:0012501 programmed cell death 0.000588641930400791 2143 63 20 0.317460317460317 0.00933271115258983
GO:BP GO:0071345 cellular response to cytokine stimulus 0.000588641930400791 1132 47 12 0.25531914893617 0.0106007067137809
GO:BP GO:0031323 regulation of cellular metabolic process 0.000592302093428864 6269 67 40 0.597014925373134 0.00638060296698038
GO:BP GO:0042221 response to chemical 0.00059711063403118 4781 8 8 1 0.00167329010667224
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.000601961025614018 1202 38 11 0.289473684210526 0.00915141430948419
GO:BP GO:0007565 female pregnancy 0.000629367111994206 198 6 3 0.5 0.0151515151515152
GO:BP GO:0009314 response to radiation 0.000664170488872627 461 8 4 0.5 0.00867678958785249
GO:BP GO:0070848 response to growth factor 0.000664170488872627 759 10 5 0.5 0.00658761528326746
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 0.000708766623854957 2518 73 24 0.328767123287671 0.00953137410643368
GO:BP GO:1901360 organic cyclic compound metabolic process 0.000733441952436886 6201 29 21 0.724137931034483 0.00338655055636188
GO:BP GO:0034616 response to laminar fluid shear stress 0.000749803012886979 16 71 3 0.0422535211267606 0.1875
GO:BP GO:0060255 regulation of macromolecule metabolic process 0.000768037853745857 6603 67 41 0.611940298507463 0.00620929880357413
GO:BP GO:0009612 response to mechanical stimulus 0.000783180577366846 218 6 3 0.5 0.0137614678899083
GO:BP GO:0035295 tube development 0.000783180577366846 1146 41 11 0.268292682926829 0.00959860383944154
GO:BP GO:0031324 negative regulation of cellular metabolic process 0.000788464716607217 2719 73 25 0.342465753424658 0.00919455682236116
GO:BP GO:0010243 response to organonitrogen compound 0.000843863384470544 1085 8 5 0.625 0.00460829493087558
GO:BP GO:0044706 multi-multicellular organism process 0.000861372081873343 227 6 3 0.5 0.013215859030837
GO:BP GO:1903706 regulation of hemopoiesis 0.000873829161736546 424 28 6 0.214285714285714 0.0141509433962264
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.000938084924030945 3483 121 42 0.347107438016529 0.0120585701981051
GO:BP GO:0010628 positive regulation of gene expression 0.000994600312132502 1160 49 12 0.244897959183673 0.0103448275862069
GO:BP GO:0021517 ventral spinal cord development 0.000994600312132502 45 28 3 0.107142857142857 0.0666666666666667
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.00100565469444101 263 28 5 0.178571428571429 0.0190114068441065
GO:BP GO:0060548 negative regulation of cell death 0.00102347221773451 1038 63 13 0.206349206349206 0.01252408477842
GO:BP GO:0048522 positive regulation of cellular process 0.00102347221773451 5757 14 12 0.857142857142857 0.00208441896821261
GO:BP GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 0.00103900434803932 13 103 3 0.029126213592233 0.230769230769231
GO:BP GO:0002521 leukocyte differentiation 0.00111661873317208 550 8 4 0.5 0.00727272727272727
GO:BP GO:1901698 response to nitrogen compound 0.00111661873317208 1172 8 5 0.625 0.00426621160409556
GO:BP GO:1901983 regulation of protein acetylation 0.00120824359467218 78 49 4 0.0816326530612245 0.0512820512820513
GO:BP GO:0009893 positive regulation of metabolic process 0.00124871442632746 3783 121 44 0.363636363636364 0.0116309807031457
GO:BP GO:0021515 cell differentiation in spinal cord 0.00125680080379159 50 28 3 0.107142857142857 0.06
GO:BP GO:0097305 response to alcohol 0.001272759054682 255 96 8 0.0833333333333333 0.0313725490196078
GO:BP GO:0043066 negative regulation of apoptotic process 0.00133987369712455 921 63 12 0.19047619047619 0.0130293159609121
GO:BP GO:0042127 regulation of cell population proliferation 0.00137850582873461 1774 40 13 0.325 0.00732807215332582
GO:BP GO:0019222 regulation of metabolic process 0.00140262015485238 7148 49 33 0.673469387755102 0.00461667599328484
GO:BP GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening 0.00145605565204936 15 103 3 0.029126213592233 0.2
GO:BP GO:0071384 cellular response to corticosteroid stimulus 0.00145605565204936 63 24 3 0.125 0.0476190476190476
GO:BP GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 0.00145605565204936 15 103 3 0.029126213592233 0.2
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 0.00145605565204936 111 37 4 0.108108108108108 0.036036036036036
GO:BP GO:0097306 cellular response to alcohol 0.00145605565204936 93 85 5 0.0588235294117647 0.0537634408602151
GO:BP GO:0001824 blastocyst development 0.00149671281995492 104 124 6 0.0483870967741935 0.0576923076923077
GO:BP GO:0043069 negative regulation of programmed cell death 0.00155312923663314 943 63 12 0.19047619047619 0.0127253446447508
GO:BP GO:0033554 cellular response to stress 0.00155312923663314 2111 49 16 0.326530612244898 0.00757934628138323
GO:BP GO:0030218 erythrocyte differentiation 0.00162391601419835 116 37 4 0.108108108108108 0.0344827586206897
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 0.00166148984149759 117 37 4 0.108108108108108 0.0341880341880342
GO:BP GO:1902373 negative regulation of mRNA catabolic process 0.00177996604567181 60 73 4 0.0547945205479452 0.0666666666666667
GO:BP GO:0046629 gamma-delta T cell activation 0.00190999356166189 18 95 3 0.0315789473684211 0.166666666666667
GO:BP GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 0.00198978049499146 17 103 3 0.029126213592233 0.176470588235294
GO:BP GO:0007049 cell cycle 0.00198978049499146 1902 72 19 0.263888888888889 0.00998948475289169
GO:BP GO:0010942 positive regulation of cell death 0.00198978049499146 684 14 5 0.357142857142857 0.00730994152046784
GO:BP GO:0034101 erythrocyte homeostasis 0.00199834982651533 124 37 4 0.108108108108108 0.032258064516129
GO:BP GO:0001701 in utero embryonic development 0.00216313466652504 365 56 7 0.125 0.0191780821917808
GO:BP GO:0043170 macromolecule metabolic process 0.0022877289013423 9796 76 57 0.75 0.00581870151082074
GO:BP GO:0048583 regulation of response to stimulus 0.00237469326636844 4278 50 24 0.48 0.00561009817671809
GO:BP GO:0043484 regulation of RNA splicing 0.00241841821339278 160 57 5 0.087719298245614 0.03125
GO:BP GO:0048518 positive regulation of biological process 0.00241841821339278 6363 14 12 0.857142857142857 0.00188590287600189
GO:BP GO:0043543 protein acylation 0.00245339443938391 247 59 6 0.101694915254237 0.0242914979757085
GO:BP GO:0006979 response to oxidative stress 0.00265381406251867 466 5 3 0.6 0.00643776824034335
GO:BP GO:0000003 reproduction 0.0027581390976305 1496 8 5 0.625 0.00334224598930481
GO:BP GO:0022414 reproductive process 0.0027581390976305 1493 8 5 0.625 0.00334896182183523
GO:BP GO:0042542 response to hydrogen peroxide 0.00276056600991842 150 63 5 0.0793650793650794 0.0333333333333333
GO:BP GO:0021953 central nervous system neuron differentiation 0.00295912847502046 188 28 4 0.142857142857143 0.0212765957446809
GO:BP GO:1902369 negative regulation of RNA catabolic process 0.00299039629116927 71 73 4 0.0547945205479452 0.0563380281690141
GO:BP GO:0045292 mRNA cis splicing, via spliceosome 0.00303159854463616 36 57 3 0.0526315789473684 0.0833333333333333
GO:BP GO:0042493 response to drug 0.003037810225514 396 6 3 0.5 0.00757575757575758
GO:BP GO:0031123 RNA 3'-end processing 0.003037810225514 157 62 5 0.0806451612903226 0.0318471337579618
GO:BP GO:0035914 skeletal muscle cell differentiation 0.00347876670196876 68 80 4 0.05 0.0588235294117647
GO:BP GO:0002262 myeloid cell homeostasis 0.00369544996621834 151 37 4 0.108108108108108 0.0264900662251656
GO:BP GO:0021915 neural tube development 0.00377801915369442 158 65 5 0.0769230769230769 0.0316455696202532
GO:BP GO:1901985 positive regulation of protein acetylation 0.00379528780770701 46 49 3 0.0612244897959184 0.0652173913043478
GO:BP GO:0009790 embryo development 0.00382532107961143 1035 47 10 0.212765957446809 0.00966183574879227
GO:BP GO:0062197 cellular response to chemical stress 0.00383746102751172 365 63 7 0.111111111111111 0.0191780821917808
GO:BP GO:0002376 immune system process 0.00400529209235514 3278 12 8 0.666666666666667 0.0024405125076266
GO:BP GO:0007275 multicellular organism development 0.00403943344702745 5613 28 18 0.642857142857143 0.00320684126135756
GO:BP GO:1901214 regulation of neuron death 0.00415172316665293 323 8 3 0.375 0.00928792569659443
GO:BP GO:0045597 positive regulation of cell differentiation 0.00419295143209393 879 28 7 0.25 0.00796359499431172
GO:BP GO:0008283 cell population proliferation 0.00428982374290673 2054 40 13 0.325 0.00632911392405063
GO:BP GO:0048598 embryonic morphogenesis 0.00462603376906307 595 41 7 0.170731707317073 0.0117647058823529
GO:BP GO:0048255 mRNA stabilization 0.00474053671337696 53 47 3 0.0638297872340425 0.0566037735849057
GO:BP GO:0003281 ventricular septum development 0.0048146639371201 68 37 3 0.0810810810810811 0.0441176470588235
GO:BP GO:0051028 mRNA transport 0.00482712782976632 152 17 3 0.176470588235294 0.0197368421052632
GO:BP GO:0006807 nitrogen compound metabolic process 0.00489740534056799 10078 76 57 0.75 0.00565588410398889
GO:BP GO:0006396 RNA processing 0.00490623039295126 964 82 13 0.158536585365854 0.0134854771784232
GO:BP GO:0045638 negative regulation of myeloid cell differentiation 0.00520414304317871 94 28 3 0.107142857142857 0.0319148936170213
GO:BP GO:0071363 cellular response to growth factor stimulus 0.00574341887279579 731 10 4 0.4 0.00547195622435021
GO:BP GO:0035019 somatic stem cell population maintenance 0.00577254184388947 72 38 3 0.0789473684210526 0.0416666666666667
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 0.00577254184388947 3241 49 19 0.387755102040816 0.005862388151805
GO:BP GO:0031124 mRNA 3'-end processing 0.00594059219972412 106 62 4 0.0645161290322581 0.0377358490566038
GO:BP GO:2000756 regulation of peptidyl-lysine acetylation 0.00596128036158948 63 44 3 0.0681818181818182 0.0476190476190476
GO:BP GO:0043489 RNA stabilization 0.00656273350397961 61 47 3 0.0638297872340425 0.0491803278688525
GO:BP GO:0021510 spinal cord development 0.00660098670834464 104 28 3 0.107142857142857 0.0288461538461538
GO:BP GO:0006473 protein acetylation 0.00660098670834464 205 59 5 0.0847457627118644 0.024390243902439
GO:BP GO:0045727 positive regulation of translation 0.00660098670834464 140 49 4 0.0816326530612245 0.0285714285714286
GO:BP GO:0009653 anatomical structure morphogenesis 0.00660098670834464 2797 44 16 0.363636363636364 0.00572041473006793
GO:BP GO:0001841 neural tube formation 0.00660098670834464 105 65 4 0.0615384615384615 0.0380952380952381
GO:BP GO:1903311 regulation of mRNA metabolic process 0.00679501343037505 356 73 7 0.0958904109589041 0.0196629213483146
GO:BP GO:0006950 response to stress 0.00689663007623745 4170 49 22 0.448979591836735 0.0052757793764988
GO:BP GO:0008380 RNA splicing 0.00689663007623745 456 75 8 0.106666666666667 0.0175438596491228
GO:BP GO:2000026 regulation of multicellular organismal development 0.00709808489269864 1447 38 10 0.263157894736842 0.00691085003455425
GO:BP GO:0045926 negative regulation of growth 0.00710269833504531 255 49 5 0.102040816326531 0.0196078431372549
GO:BP GO:0001892 embryonic placenta development 0.00742719611984755 83 37 3 0.0810810810810811 0.036144578313253
GO:BP GO:0048523 negative regulation of cellular process 0.00764168843362263 5139 49 25 0.510204081632653 0.00486475968087176
GO:BP GO:0010458 exit from mitosis 0.0078174014298718 30 105 3 0.0285714285714286 0.1
GO:BP GO:0007519 skeletal muscle tissue development 0.0080564099255812 160 80 5 0.0625 0.03125
GO:BP GO:0044237 cellular metabolic process 0.00807996386720524 10871 67 53 0.791044776119403 0.00487535645294821
GO:BP GO:0050657 nucleic acid transport 0.00896652018515165 201 17 3 0.176470588235294 0.0149253731343284
GO:BP GO:0050658 RNA transport 0.00896652018515165 201 17 3 0.176470588235294 0.0149253731343284
GO:BP GO:0051236 establishment of RNA localization 0.00932600310508183 204 17 3 0.176470588235294 0.0147058823529412
GO:BP GO:0048856 anatomical structure development 0.00949983917170366 6106 16 12 0.75 0.00196528005240747
GO:BP GO:0016071 mRNA metabolic process 0.00960878714534795 874 75 11 0.146666666666667 0.0125858123569794
GO:BP GO:0044260 cellular macromolecule metabolic process 0.00977620608399656 8390 49 34 0.693877551020408 0.00405244338498212
GO:BP GO:0060538 skeletal muscle organ development 0.00995019577596582 170 80 5 0.0625 0.0294117647058824
GO:BP GO:0045786 negative regulation of cell cycle 0.0107961970044089 647 72 9 0.125 0.0139103554868624
GO:BP GO:0071347 cellular response to interleukin-1 0.0109410352582896 185 44 4 0.0909090909090909 0.0216216216216216
GO:BP GO:0001838 embryonic epithelial tube formation 0.0110523416241705 125 65 4 0.0615384615384615 0.032
GO:BP GO:0048731 system development 0.0112509812449631 5052 28 16 0.571428571428571 0.00316706254948535
GO:BP GO:1901655 cellular response to ketone 0.0113065665024182 97 38 3 0.0789473684210526 0.0309278350515464
GO:BP GO:0071407 cellular response to organic cyclic compound 0.0113065665024182 587 25 5 0.2 0.00851788756388416
GO:BP GO:0051246 regulation of protein metabolic process 0.01154190240145 2704 66 20 0.303030303030303 0.00739644970414201
GO:BP GO:0042401 cellular biogenic amine biosynthetic process 0.0115681061786376 38 98 3 0.0306122448979592 0.0789473684210526
GO:BP GO:0009892 negative regulation of metabolic process 0.0116277013809107 3479 49 19 0.387755102040816 0.00546133946536361
GO:BP GO:0002682 regulation of immune system process 0.0117018496242633 1617 31 9 0.290322580645161 0.00556586270871985
GO:BP GO:0034250 positive regulation of cellular amide metabolic process 0.0117531784621204 171 49 4 0.0816326530612245 0.0233918128654971
GO:BP GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening 0.0120752594698701 37 103 3 0.029126213592233 0.0810810810810811
GO:BP GO:0009309 amine biosynthetic process 0.0120752594698701 39 98 3 0.0306122448979592 0.0769230769230769
GO:BP GO:0018394 peptidyl-lysine acetylation 0.012214951078106 172 125 6 0.048 0.0348837209302326
GO:BP GO:0003279 cardiac septum development 0.012214951078106 104 37 3 0.0810810810810811 0.0288461538461538
GO:BP GO:0009888 tissue development 0.0123238738284208 2107 16 7 0.4375 0.00332225913621262
GO:BP GO:0006446 regulation of translational initiation 0.0127544623253962 80 49 3 0.0612244897959184 0.0375
GO:BP GO:0006403 RNA localization 0.0127549253660199 238 17 3 0.176470588235294 0.0126050420168067
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0130939440161114 2541 66 19 0.287878787878788 0.00747737111373475
GO:BP GO:0000398 mRNA splicing, via spliceosome 0.013677345813918 361 62 6 0.0967741935483871 0.0166204986149584
GO:BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 0.013677345813918 361 62 6 0.0967741935483871 0.0166204986149584
GO:BP GO:0006417 regulation of translation 0.0139008525353178 462 49 6 0.122448979591837 0.012987012987013
GO:BP GO:0051094 positive regulation of developmental process 0.0139231587663151 1341 38 9 0.236842105263158 0.00671140939597315
GO:BP GO:0010629 negative regulation of gene expression 0.0139231587663151 1460 49 11 0.224489795918367 0.00753424657534247
GO:BP GO:0001825 blastocyst formation 0.0139231587663151 38 108 3 0.0277777777777778 0.0789473684210526
GO:BP GO:0072175 epithelial tube formation 0.0139231587663151 137 65 4 0.0615384615384615 0.0291970802919708
GO:BP GO:0000375 RNA splicing, via transesterification reactions 0.0139598025120048 364 62 6 0.0967741935483871 0.0164835164835165
GO:BP GO:0006970 response to osmotic stress 0.0140499506998392 84 49 3 0.0612244897959184 0.0357142857142857
GO:BP GO:0006397 mRNA processing 0.0144346940857117 532 75 8 0.106666666666667 0.0150375939849624
GO:BP GO:0051338 regulation of transferase activity 0.014769049473356 1035 49 9 0.183673469387755 0.00869565217391304
GO:BP GO:0001525 angiogenesis 0.014769049473356 617 38 6 0.157894736842105 0.00972447325769854
GO:BP GO:0015931 nucleobase-containing compound transport 0.015141906754507 260 17 3 0.176470588235294 0.0115384615384615
GO:BP GO:0051093 negative regulation of developmental process 0.0153626092223455 977 73 11 0.150684931506849 0.0112589559877175
GO:BP GO:0030308 negative regulation of cell growth 0.0154721933544262 192 49 4 0.0816326530612245 0.0208333333333333
GO:BP GO:0070555 response to interleukin-1 0.0156064806765615 215 44 4 0.0909090909090909 0.0186046511627907
GO:BP GO:0003231 cardiac ventricle development 0.0160136157849343 120 37 3 0.0810810810810811 0.025
GO:BP GO:0000381 regulation of alternative mRNA splicing, via spliceosome 0.0161677697564185 78 57 3 0.0526315789473684 0.0384615384615385
GO:BP GO:0065009 regulation of molecular function 0.0162093894300699 3221 12 7 0.583333333333333 0.00217323812480596
GO:BP GO:0007346 regulation of mitotic cell cycle 0.0164879231412538 619 67 8 0.119402985074627 0.012924071082391
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 0.0164879231412538 172 56 4 0.0714285714285714 0.0232558139534884
GO:BP GO:0032502 developmental process 0.016963920546769 6628 16 12 0.75 0.00181050090525045
GO:BP GO:0051101 regulation of DNA binding 0.0172304314107203 121 38 3 0.0789473684210526 0.0247933884297521
GO:BP GO:0032642 regulation of chemokine production 0.0173399094201384 94 49 3 0.0612244897959184 0.0319148936170213
GO:BP GO:0032101 regulation of response to external stimulus 0.0173399094201384 1051 50 9 0.18 0.00856327307326356
GO:BP GO:0070498 interleukin-1-mediated signaling pathway 0.0173410099558719 105 44 3 0.0681818181818182 0.0285714285714286
GO:BP GO:0006413 translational initiation 0.0173410099558719 201 49 4 0.0816326530612245 0.0199004975124378
GO:BP GO:0016331 morphogenesis of embryonic epithelium 0.0173541187924783 151 65 4 0.0615384615384615 0.0264900662251656
GO:BP GO:0009605 response to external stimulus 0.0173562394432732 2944 10 6 0.6 0.00203804347826087
GO:BP GO:0035148 tube formation 0.0176326786749388 152 65 4 0.0615384615384615 0.0263157894736842
GO:BP GO:0051239 regulation of multicellular organismal process 0.0178926352800474 2861 57 18 0.315789473684211 0.00629150646627053
GO:BP GO:0040008 regulation of growth 0.017939548005854 681 49 7 0.142857142857143 0.0102790014684288
GO:BP GO:1903047 mitotic cell cycle process 0.0184378002779797 911 105 13 0.123809523809524 0.0142700329308452
GO:BP GO:0060070 canonical Wnt signaling pathway 0.0184889115126521 345 49 5 0.102040816326531 0.0144927536231884
GO:BP GO:0035270 endocrine system development 0.0185445088044449 130 37 3 0.0810810810810811 0.0230769230769231
GO:BP GO:0030154 cell differentiation 0.0194768361565385 4350 28 14 0.5 0.0032183908045977
GO:BP GO:0032602 chemokine production 0.019910461465806 101 49 3 0.0612244897959184 0.0297029702970297
GO:BP GO:0071383 cellular response to steroid hormone stimulus 0.019929602197131 210 24 3 0.125 0.0142857142857143
GO:BP GO:0032501 multicellular organismal process 0.019929602197131 7946 16 13 0.8125 0.0016360432922225
GO:BP GO:0050896 response to stimulus 0.019929602197131 9407 13 12 0.923076923076923 0.00127564579568407
GO:BP GO:0040007 growth 0.0203542530121452 967 56 9 0.160714285714286 0.0093071354705274
GO:BP GO:0009791 post-embryonic development 0.0207051922369224 84 125 4 0.032 0.0476190476190476
GO:BP GO:0000380 alternative mRNA splicing, via spliceosome 0.0208955109549386 89 57 3 0.0526315789473684 0.0337078651685393
GO:BP GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 0.0212218674978793 81 63 3 0.0476190476190476 0.037037037037037
GO:BP GO:0045595 regulation of cell differentiation 0.0212972985918381 1679 22 7 0.318181818181818 0.00416914830256105
GO:BP GO:0007050 cell cycle arrest 0.0221955532929642 241 22 3 0.136363636363636 0.012448132780083
GO:BP GO:0048869 cellular developmental process 0.0223648821544791 4428 28 14 0.5 0.0031616982836495
GO:BP GO:0034248 regulation of cellular amide metabolic process 0.022365547824632 535 49 6 0.122448979591837 0.011214953271028
GO:BP GO:0030182 neuron differentiation 0.022365547824632 1412 55 11 0.2 0.00779036827195467
GO:BP GO:0044092 negative regulation of molecular function 0.022365547824632 1219 10 4 0.4 0.00328137817883511
GO:BP GO:0043549 regulation of kinase activity 0.022365547824632 921 49 8 0.163265306122449 0.00868621064060804
GO:BP GO:0000278 mitotic cell cycle 0.0227547161162308 1059 105 14 0.133333333333333 0.0132200188857413
GO:BP GO:0061014 positive regulation of mRNA catabolic process 0.0231127347973 52 103 3 0.029126213592233 0.0576923076923077
GO:BP GO:0044703 multi-organism reproductive process 0.0234014523804957 1040 6 3 0.5 0.00288461538461538
GO:BP GO:0050790 regulation of catalytic activity 0.0234014523804957 2545 12 6 0.5 0.00235756385068762
GO:BP GO:0001890 placenta development 0.0234062645449528 147 37 3 0.0810810810810811 0.0204081632653061
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 0.0245418145825599 243 76 5 0.0657894736842105 0.0205761316872428
GO:BP GO:2000117 negative regulation of cysteine-type endopeptidase activity 0.0252524647819168 89 63 3 0.0476190476190476 0.0337078651685393
GO:BP GO:0006518 peptide metabolic process 0.0259662204031828 955 49 8 0.163265306122449 0.00837696335078534
GO:BP GO:0048519 negative regulation of biological process 0.0263896302459673 5757 49 25 0.510204081632653 0.00434253951710961
GO:BP GO:0019827 stem cell population maintenance 0.0265585339091732 152 38 3 0.0789473684210526 0.0197368421052632
GO:BP GO:0003205 cardiac chamber development 0.0269379844809843 161 37 3 0.0810810810810811 0.0186335403726708
GO:BP GO:0098727 maintenance of cell number 0.0269379844809843 154 38 3 0.0789473684210526 0.0194805194805195
GO:BP GO:0001843 neural tube closure 0.0269379844809843 91 65 3 0.0461538461538462 0.032967032967033
GO:BP GO:0006412 translation 0.0269379844809843 764 49 7 0.142857142857143 0.00916230366492147
GO:BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 0.0269379844809843 182 105 5 0.0476190476190476 0.0274725274725275
GO:BP GO:0044238 primary metabolic process 0.0269379844809843 10584 76 56 0.736842105263158 0.00529100529100529
GO:BP GO:0042592 homeostatic process 0.0269379844809843 1981 85 18 0.211764705882353 0.00908632004038364
GO:BP GO:0051704 multi-organism process 0.0269379844809843 1135 6 3 0.5 0.0026431718061674
GO:BP GO:0050793 regulation of developmental process 0.0269379844809843 2605 28 10 0.357142857142857 0.00383877159309021
GO:BP GO:0032784 regulation of DNA-templated transcription, elongation 0.0269379844809843 51 114 3 0.0263157894736842 0.0588235294117647
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0269379844809843 810 8 3 0.375 0.0037037037037037
GO:BP GO:0060606 tube closure 0.0272566307390387 92 65 3 0.0461538461538462 0.0326086956521739
GO:BP GO:1904035 regulation of epithelial cell apoptotic process 0.0272566307390387 105 57 3 0.0526315789473684 0.0285714285714286
GO:BP GO:0070534 protein K63-linked ubiquitination 0.0275842104071688 59 102 3 0.0294117647058824 0.0508474576271186
GO:BP GO:0008152 metabolic process 0.0280348678909695 11827 67 54 0.805970149253731 0.00456582396212057
GO:BP GO:0016573 histone acetylation 0.0284693933874271 157 125 5 0.04 0.0318471337579618
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.0293385277509249 1455 49 10 0.204081632653061 0.00687285223367698
GO:BP GO:0043043 peptide biosynthetic process 0.0300330717995982 790 49 7 0.142857142857143 0.00886075949367089
GO:BP GO:0045930 negative regulation of mitotic cell cycle 0.0300330717995982 333 38 4 0.105263157894737 0.012012012012012
GO:BP GO:0014020 primary neural tube formation 0.0301148698320327 97 65 3 0.0461538461538462 0.0309278350515464
GO:BP GO:0071214 cellular response to abiotic stimulus 0.0304757774438651 339 85 6 0.0705882352941176 0.0176991150442478
GO:BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 0.0304757774438651 148 85 4 0.0470588235294118 0.027027027027027
GO:BP GO:0104004 cellular response to environmental stimulus 0.0304757774438651 339 85 6 0.0705882352941176 0.0176991150442478
GO:BP GO:0018393 internal peptidyl-lysine acetylation 0.0308553513808528 162 125 5 0.04 0.0308641975308642
GO:BP GO:0070301 cellular response to hydrogen peroxide 0.0310736175984436 102 63 3 0.0476190476190476 0.0294117647058824
GO:BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 0.0313251161835978 81 80 3 0.0375 0.037037037037037
GO:BP GO:0048513 animal organ development 0.0313251161835978 3672 28 12 0.428571428571429 0.00326797385620915
GO:BP GO:0043065 positive regulation of apoptotic process 0.0313883866378075 604 22 4 0.181818181818182 0.00662251655629139
GO:BP GO:1901652 response to peptide 0.031626042028942 551 38 5 0.131578947368421 0.00907441016333938
GO:BP GO:0006475 internal protein amino acid acetylation 0.031632659319362 164 125 5 0.04 0.0304878048780488
GO:BP GO:0006913 nucleocytoplasmic transport 0.031774313931376 354 19 3 0.157894736842105 0.00847457627118644
GO:BP GO:0001558 regulation of cell growth 0.031774313931376 426 49 5 0.102040816326531 0.0117370892018779
GO:BP GO:0051169 nuclear transport 0.0321419049312994 357 19 3 0.157894736842105 0.00840336134453781
GO:BP GO:0043068 positive regulation of programmed cell death 0.0330643372366684 621 22 4 0.181818181818182 0.00644122383252818
GO:BP GO:0043085 positive regulation of catalytic activity 0.0330643372366684 1418 16 5 0.3125 0.00352609308885755
GO:BP GO:0071704 organic substance metabolic process 0.0330643372366684 11326 67 52 0.776119402985075 0.00459120607451881
GO:BP GO:0006576 cellular biogenic amine metabolic process 0.0333508848463889 106 125 4 0.032 0.0377358490566038
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 0.0338054493777759 451 67 6 0.0895522388059701 0.0133037694013304
GO:BP GO:0048699 generation of neurons 0.0340847397639278 1559 55 11 0.2 0.00705580500320718
GO:BP GO:0045765 regulation of angiogenesis 0.0342019967137858 358 38 4 0.105263157894737 0.0111731843575419
GO:BP GO:0071396 cellular response to lipid 0.0343530236065855 578 24 4 0.166666666666667 0.0069204152249135
GO:BP GO:0040029 regulation of gene expression, epigenetic 0.0346888477650761 206 34 3 0.0882352941176471 0.0145631067961165
GO:BP GO:1901342 regulation of vasculature development 0.035261632483225 364 38 4 0.105263157894737 0.010989010989011
GO:BP GO:1902806 regulation of cell cycle G1/S phase transition 0.0355217154379321 206 105 5 0.0476190476190476 0.0242718446601942
GO:BP GO:0045766 positive regulation of angiogenesis 0.0355217154379321 187 38 3 0.0789473684210526 0.0160427807486631
GO:BP GO:1904018 positive regulation of vasculature development 0.0355217154379321 187 38 3 0.0789473684210526 0.0160427807486631
GO:BP GO:0044772 mitotic cell cycle phase transition 0.0359210858292947 609 67 7 0.104477611940299 0.0114942528735632
GO:BP GO:0009966 regulation of signal transduction 0.0363305102211513 3165 49 16 0.326530612244898 0.00505529225908373
GO:BP GO:0061013 regulation of mRNA catabolic process 0.0368956518110557 213 103 5 0.0485436893203883 0.0234741784037559
GO:BP GO:0016310 phosphorylation 0.0368956518110557 2138 53 13 0.245283018867925 0.00608044901777362
GO:BP GO:0051716 cellular response to stimulus 0.0371860426133136 7781 49 30 0.612244897959184 0.0038555455596967
GO:BP GO:1904019 epithelial cell apoptotic process 0.0375573567883194 128 57 3 0.0526315789473684 0.0234375
GO:BP GO:0040011 locomotion 0.0375573567883194 2028 56 13 0.232142857142857 0.00641025641025641
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 0.0375573567883194 147 96 4 0.0416666666666667 0.0272108843537415
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0375573567883194 1160 85 12 0.141176470588235 0.0103448275862069
GO:BP GO:0048584 positive regulation of response to stimulus 0.0379803980761301 2344 49 13 0.26530612244898 0.00554607508532423
GO:BP GO:0071356 cellular response to tumor necrosis factor 0.0383632525286003 306 47 4 0.0851063829787234 0.0130718954248366
GO:BP GO:0080134 regulation of response to stress 0.038431313871956 1443 61 11 0.180327868852459 0.00762300762300762
GO:BP GO:0051128 regulation of cellular component organization 0.0388629975652303 2412 28 9 0.321428571428571 0.00373134328358209
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 0.0392610178554152 298 49 4 0.0816326530612245 0.0134228187919463
GO:BP GO:0060429 epithelium development 0.0400519172654385 1325 41 8 0.195121951219512 0.0060377358490566
GO:BP GO:0002040 sprouting angiogenesis 0.0404046772616622 204 38 3 0.0789473684210526 0.0147058823529412
GO:BP GO:0043086 negative regulation of catalytic activity 0.0407444099244876 851 63 8 0.126984126984127 0.00940070505287897
GO:BP GO:0032526 response to retinoic acid 0.0410616197153044 110 71 3 0.0422535211267606 0.0272727272727273
GO:BP GO:0044267 cellular protein metabolic process 0.0410616197153044 5229 76 32 0.421052631578947 0.00611971696309046
GO:BP GO:0010646 regulation of cell communication 0.0410616197153044 3543 49 17 0.346938775510204 0.00479819362122495
GO:BP GO:0045931 positive regulation of mitotic cell cycle 0.0412758289656991 119 125 4 0.032 0.0336134453781513
GO:BP GO:1901987 regulation of cell cycle phase transition 0.0417662248511428 493 67 6 0.0895522388059701 0.0121703853955375
GO:BP GO:0040012 regulation of locomotion 0.0419066032422579 1104 40 7 0.175 0.00634057971014493
GO:BP GO:0010608 posttranscriptional regulation of gene expression 0.0424214926185181 896 49 7 0.142857142857143 0.0078125
GO:BP GO:0030217 T cell differentiation 0.042752666240153 260 91 5 0.0549450549450549 0.0192307692307692
GO:BP GO:0009968 negative regulation of signal transduction 0.042752666240153 1364 49 9 0.183673469387755 0.00659824046920821
GO:BP GO:0007626 locomotory behavior 0.0427892724841932 189 125 5 0.04 0.0264550264550265
GO:BP GO:0018205 peptidyl-lysine modification 0.043119244679483 405 59 5 0.0847457627118644 0.0123456790123457
GO:BP GO:0023051 regulation of signaling 0.0432812304211675 3578 49 17 0.346938775510204 0.00475125768585802
GO:BP GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 0.043694220617016 79 103 3 0.029126213592233 0.0379746835443038
GO:BP GO:0034612 response to tumor necrosis factor 0.043694220617016 331 25 3 0.12 0.00906344410876133
GO:BP GO:0016049 cell growth 0.0440699233289952 495 49 5 0.102040816326531 0.0101010101010101
GO:BP GO:0016055 Wnt signaling pathway 0.0440699233289952 529 103 8 0.0776699029126214 0.0151228733459357
GO:BP GO:0044770 cell cycle phase transition 0.0442639352552793 658 67 7 0.104477611940299 0.0106382978723404
GO:BP GO:0035023 regulation of Rho protein signal transduction 0.044341437541928 86 96 3 0.03125 0.0348837209302326
GO:BP GO:0198738 cell-cell signaling by wnt 0.044341437541928 531 103 8 0.0776699029126214 0.0150659133709981
GO:BP GO:0022008 neurogenesis 0.044447909306577 1675 55 11 0.2 0.00656716417910448
GO:BP GO:0048585 negative regulation of response to stimulus 0.0446282708513532 1733 10 4 0.4 0.00230813618003462
GO:BP GO:0032269 negative regulation of cellular protein metabolic process 0.045344078654095 1082 73 10 0.136986301369863 0.00924214417744917
GO:BP GO:0048871 multicellular organismal homeostasis 0.0455310971513995 530 104 8 0.0769230769230769 0.0150943396226415
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.0456723869702977 1645 49 10 0.204081632653061 0.0060790273556231
GO:BP GO:0019220 regulation of phosphate metabolic process 0.0456723869702977 1645 49 10 0.204081632653061 0.0060790273556231
GO:BP GO:0048870 cell motility 0.0459261416852473 1828 38 9 0.236842105263158 0.00492341356673961
GO:BP GO:0051674 localization of cell 0.0459261416852473 1828 38 9 0.236842105263158 0.00492341356673961
GO:BP GO:0048732 gland development 0.0460429462381038 436 37 4 0.108108108108108 0.00917431192660551
GO:BP GO:0050794 regulation of cellular process 0.0462205149356644 11473 19 17 0.894736842105263 0.00148173973677329
GO:BP GO:0007399 nervous system development 0.0462205149356644 2449 44 12 0.272727272727273 0.00489995916700694
GO:BP GO:1990830 cellular response to leukemia inhibitory factor 0.046267394888503 89 96 3 0.03125 0.0337078651685393
GO:BP GO:0031396 regulation of protein ubiquitination 0.0467045620847616 211 76 4 0.0526315789473684 0.018957345971564
GO:BP GO:0043604 amide biosynthetic process 0.0467744386807831 932 49 7 0.142857142857143 0.00751072961373391
GO:BP GO:1990823 response to leukemia inhibitory factor 0.0467744386807831 90 96 3 0.03125 0.0333333333333333
GO:BP GO:0045444 fat cell differentiation 0.0467744386807831 229 38 3 0.0789473684210526 0.0131004366812227
GO:BP GO:0061061 muscle structure development 0.0468797385411726 645 14 3 0.214285714285714 0.00465116279069767
GO:BP GO:0031399 regulation of protein modification process 0.0477320252145599 1671 49 10 0.204081632653061 0.00598444045481747
GO:BP GO:0016032 viral process 0.0479016492683146 942 49 7 0.142857142857143 0.00743099787685775
GO:BP GO:0031503 protein-containing complex localization 0.0480990324649944 289 57 4 0.0701754385964912 0.013840830449827
GO:BP GO:0051345 positive regulation of hydrolase activity 0.0487351395792583 783 12 3 0.25 0.00383141762452107
GO:BP GO:0043488 regulation of mRNA stability 0.048955728551044 191 47 3 0.0638297872340425 0.0157068062827225
GO:BP GO:0051054 positive regulation of DNA metabolic process 0.0490689668621457 203 125 5 0.04 0.0246305418719212
GO:BP GO:1903313 positive regulation of mRNA metabolic process 0.0491479297609014 87 103 3 0.029126213592233 0.0344827586206897
GO:BP GO:0042325 regulation of phosphorylation 0.0491974716986697 1431 49 9 0.183673469387755 0.00628930817610063
GO:BP GO:0001818 negative regulation of cytokine production 0.0492138279587172 381 44 4 0.0909090909090909 0.010498687664042
GO:BP GO:0006911 phagocytosis, engulfment 0.0495924271753349 127 71 3 0.0422535211267606 0.0236220472440945
GO:BP GO:0065008 regulation of biological quality 0.0496958681064525 4131 31 13 0.419354838709677 0.00314693778746066
GO:BP GO:0019538 protein metabolic process 0.049992215084743 5808 76 34 0.447368421052632 0.00585399449035813
GO:CC GO:0035976 transcription factor AP-1 complex 4.88806808964507e-09 4 4 3 0.75 0.75
GO:CC GO:0005654 nucleoplasm 3.5130522131564e-07 4102 116 54 0.46551724137931 0.0131643100926377
GO:CC GO:0031981 nuclear lumen 4.48703347529615e-06 4444 116 54 0.46551724137931 0.0121512151215122
GO:CC GO:0005634 nucleus 7.11081436690574e-05 7592 117 73 0.623931623931624 0.00961538461538462
GO:CC GO:0070013 intracellular organelle lumen 0.00011379415086089 5402 116 57 0.491379310344828 0.0105516475379489
GO:CC GO:0005667 transcription regulator complex 0.00011379415086089 432 38 8 0.210526315789474 0.0185185185185185
GO:CC GO:0090575 RNA polymerase II transcription regulator complex 0.000174157571109577 183 4 3 0.75 0.0163934426229508
GO:CC GO:0043233 organelle lumen 0.000209437863686636 5565 116 57 0.491379310344828 0.0102425876010782
GO:CC GO:0031974 membrane-enclosed lumen 0.000209437863686636 5565 116 57 0.491379310344828 0.0102425876010782
GO:CC GO:0000785 chromatin 0.00434271323428987 1526 38 11 0.289473684210526 0.0072083879423329
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.00948836084678237 11296 84 65 0.773809523809524 0.0057542492917847
GO:CC GO:0016607 nuclear speck 0.0104374803778282 412 65 7 0.107692307692308 0.0169902912621359
GO:CC GO:0005694 chromosome 0.0125715539711494 2071 8 5 0.625 0.00241429261226461
GO:CC GO:0032991 protein-containing complex 0.0147111709757122 5548 69 33 0.478260869565217 0.00594808940158616
GO:CC GO:0140513 nuclear protein-containing complex 0.0156891502494053 1249 121 18 0.148760330578512 0.0144115292233787
GO:CC GO:0016604 nuclear body 0.0159564287878314 816 98 12 0.122448979591837 0.0147058823529412
GO:CC GO:0140535 intracellular protein-containing complex 0.0496053070433829 767 122 12 0.0983606557377049 0.015645371577575
GO:MF GO:0008134 transcription factor binding 5.48686780289485e-05 676 49 12 0.244897959183673 0.0177514792899408
GO:MF GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6.536485741465e-05 451 8 5 0.625 0.0110864745011086
GO:MF GO:0001216 DNA-binding transcription activator activity 6.536485741465e-05 455 8 5 0.625 0.010989010989011
GO:MF GO:0010385 double-stranded methylated DNA binding 0.00049790365861246 6 125 3 0.024 0.5
GO:MF GO:0140110 transcription regulator activity 0.000545316837455068 1935 125 30 0.24 0.0155038759689922
GO:MF GO:0046332 SMAD binding 0.000743498887830585 78 73 5 0.0684931506849315 0.0641025641025641
GO:MF GO:0140297 DNA-binding transcription factor binding 0.00106131444867132 391 42 7 0.166666666666667 0.0179028132992327
GO:MF GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding 0.00147406847048314 281 42 6 0.142857142857143 0.0213523131672598
GO:MF GO:0000987 cis-regulatory region sequence-specific DNA binding 0.00182451942075946 1209 8 5 0.625 0.00413564929693962
GO:MF GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 0.00182451942075946 1190 8 5 0.625 0.00420168067226891
GO:MF GO:0003677 DNA binding 0.00192852424965155 2486 10 7 0.7 0.00281576830249397
GO:MF GO:0003700 DNA-binding transcription factor activity 0.00198743117224839 1441 11 6 0.545454545454545 0.00416377515614157
GO:MF GO:0003729 mRNA binding 0.00211213557869895 552 62 9 0.145161290322581 0.016304347826087
GO:MF GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.00245150173363291 1375 8 5 0.625 0.00363636363636364
GO:MF GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 0.00260308102319813 1408 8 5 0.625 0.00355113636363636
GO:MF GO:0003682 chromatin binding 0.00264007277105653 571 125 13 0.104 0.0227670753064799
GO:MF GO:0000976 transcription regulatory region sequence-specific DNA binding 0.00299846545011285 1507 8 5 0.625 0.0033178500331785
GO:MF GO:0019900 kinase binding 0.00299846545011285 752 14 5 0.357142857142857 0.00664893617021277
GO:MF GO:0001067 regulatory region nucleic acid binding 0.00299846545011285 1509 8 5 0.625 0.00331345261762757
GO:MF GO:1990837 sequence-specific double-stranded DNA binding 0.00347367229243995 1570 8 5 0.625 0.00318471337579618
GO:MF GO:0003690 double-stranded DNA binding 0.00418180637675073 1664 8 5 0.625 0.00300480769230769
GO:MF GO:0003676 nucleic acid binding 0.00418180637675073 4276 62 27 0.435483870967742 0.00631431244153414
GO:MF GO:0043565 sequence-specific DNA binding 0.00418180637675073 1673 8 5 0.625 0.00298864315600717
GO:MF GO:0019899 enzyme binding 0.00551375934892196 2074 14 7 0.5 0.00337512054001929
GO:MF GO:0003723 RNA binding 0.00588129142238966 1943 67 17 0.253731343283582 0.00874935666495111
GO:MF GO:0043021 ribonucleoprotein complex binding 0.0108232378069166 137 56 4 0.0714285714285714 0.0291970802919708
GO:MF GO:0019901 protein kinase binding 0.0123670291721406 673 13 4 0.307692307692308 0.00594353640416048
GO:MF GO:0008013 beta-catenin binding 0.013992822335375 87 98 4 0.0408163265306122 0.0459770114942529
GO:MF GO:0003712 transcription coregulator activity 0.0216141171858637 506 125 10 0.08 0.0197628458498024
GO:MF GO:1901363 heterocyclic compound binding 0.0219402330435032 6228 62 32 0.516129032258065 0.00513808606294155
GO:MF GO:0097159 organic cyclic compound binding 0.025427175327714 6309 62 32 0.516129032258065 0.00507211919480108
GO:MF GO:0008270 zinc ion binding 0.0257713780744485 833 121 13 0.107438016528926 0.0156062424969988
GO:MF GO:0003714 transcription corepressor activity 0.0478818411382861 187 125 5 0.04 0.0267379679144385
KEGG KEGG:04380 Osteoclast differentiation 0.000121398562675213 125 6 4 0.666666666666667 0.032
KEGG KEGG:05031 Amphetamine addiction 0.000586594984944379 69 6 3 0.5 0.0434782608695652
KEGG KEGG:04668 TNF signaling pathway 0.000586594984944379 112 4 3 0.75 0.0267857142857143
KEGG KEGG:04657 IL-17 signaling pathway 0.00104763600820639 92 6 3 0.5 0.0326086956521739
KEGG KEGG:05418 Fluid shear stress and atherosclerosis 0.0012859839888435 138 5 3 0.6 0.0217391304347826
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 0.0012859839888435 216 10 4 0.4 0.0185185185185185
KEGG KEGG:04210 Apoptosis 0.00179349009945186 136 19 4 0.210526315789474 0.0294117647058824
KEGG KEGG:04010 MAPK signaling pathway 0.00234030665205816 294 5 3 0.6 0.0102040816326531
REAC REAC:R-HSA-9031628 NGF-stimulated transcription 4.79410421865234e-06 39 8 4 0.5 0.102564102564103
REAC REAC:R-HSA-198725 Nuclear Events (kinase and transcription factor activation) 1.51069169176411e-05 61 8 4 0.5 0.0655737704918033
REAC REAC:R-HSA-187037 Signaling by NTRK1 (TRKA) 8.8507876781395e-05 112 8 4 0.5 0.0357142857142857
REAC REAC:R-HSA-166520 Signaling by NTRKs 0.000128785223593896 130 8 4 0.5 0.0307692307692308
REAC REAC:R-HSA-9018519 Estrogen-dependent gene expression 0.00134363058498821 112 6 3 0.5 0.0267857142857143
REAC REAC:R-HSA-8939211 ESR-mediated signaling 0.00148183626548601 181 6 3 0.5 0.0165745856353591
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.00211590603167839 842 8 5 0.625 0.00593824228028504
REAC REAC:R-HSA-9006931 Signaling by Nuclear Receptors 0.00340104932973385 255 6 3 0.5 0.0117647058823529
REAC REAC:R-HSA-9006934 Signaling by Receptor Tyrosine Kinases 0.00340104932973385 485 8 4 0.5 0.00824742268041237
REAC REAC:R-HSA-449147 Signaling by Interleukins 0.00356490646993249 446 4 3 0.75 0.00672645739910314
REAC REAC:R-HSA-72187 mRNA 3'-end processing 0.00370716320664906 56 62 4 0.0645161290322581 0.0714285714285714
REAC REAC:R-HSA-162582 Signal Transduction 0.00514673640098189 2705 8 7 0.875 0.00258780036968577
REAC REAC:R-HSA-73856 RNA Polymerase II Transcription Termination 0.00623226309737765 65 62 4 0.0645161290322581 0.0615384615384615
REAC REAC:R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 0.00631343295722819 17 105 3 0.0285714285714286 0.176470588235294
REAC REAC:R-HSA-72163 mRNA Splicing - Major Pathway 0.00631343295722819 178 62 6 0.0967741935483871 0.0337078651685393
REAC REAC:R-HSA-72172 mRNA Splicing 0.00758481839108271 186 62 6 0.0967741935483871 0.032258064516129
REAC REAC:R-HSA-73857 RNA Polymerase II Transcription 0.0128066632634469 1301 69 18 0.260869565217391 0.0138355111452729
REAC REAC:R-HSA-9614085 FOXO-mediated transcription 0.0152483472728554 66 38 3 0.0789473684210526 0.0454545454545455
REAC REAC:R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 0.0203810801387489 235 62 6 0.0967741935483871 0.025531914893617
REAC REAC:R-HSA-74160 Gene expression (Transcription) 0.0260757581707256 1435 38 12 0.315789473684211 0.00836236933797909
REAC REAC:R-HSA-212436 Generic Transcription Pathway 0.0346858904573165 1180 4 3 0.75 0.00254237288135593
REAC REAC:R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 0.0361913211619904 42 91 3 0.032967032967033 0.0714285714285714
REAC REAC:R-HSA-168256 Immune System 0.043811180380075 2139 5 4 0.8 0.0018700327255727
TF TF:M00177_1 Factor: CREB; motif: NSTGACGTAANN; match class: 1 0.000192518807542359 1363 17 10 0.588235294117647 0.00733675715333822
TF TF:M00178_1 Factor: CREB; motif: NSTGACGTMANN; match class: 1 0.000324444026264149 1522 14 9 0.642857142857143 0.00591327201051248
TF TF:M09887_1 Factor: CREB1; motif: NRRTGACGTMA; match class: 1 0.000324444026264149 1616 17 10 0.588235294117647 0.00618811881188119
TF TF:M00981_1 Factor: CREB,; motif: NTGACGTNA; match class: 1 0.00286896434458262 2904 14 10 0.714285714285714 0.0034435261707989
TF TF:M11309_1 Factor: ATF-2; motif: NRTGACGTMANN; match class: 1 0.00286896434458262 2293 8 7 0.875 0.00305276929786306
TF TF:M01861 Factor: ATF-1; motif: TNACGTCAN 0.00286896434458262 6294 17 15 0.882352941176471 0.00238322211630124
TF TF:M00017_1 Factor: ATF; motif: CNSTGACGTNNNYC; match class: 1 0.00312316590456144 2222 14 9 0.642857142857143 0.00405040504050405
TF TF:M01864 Factor: ATF-4; motif: KACGTCAKS 0.00336024335206183 4477 15 12 0.8 0.00268036631672995
TF TF:M00916_1 Factor: CREB; motif: NNTKACGTCANNNS; match class: 1 0.00387417392827944 1692 14 8 0.571428571428571 0.00472813238770686
TF TF:M00179_1 Factor: ATF2; motif: VGTGACGTMACN; match class: 1 0.00421628088520911 1778 14 8 0.571428571428571 0.00449943757030371
TF TF:M00917_1 Factor: CREB; motif: CNNTGACGTMA; match class: 1 0.00421628088520911 1590 8 6 0.75 0.00377358490566038
TF TF:M09866 Factor: ATF-1; motif: NNRTGACGYMA 0.00421628088520911 3162 17 11 0.647058823529412 0.00347881087919039
TF TF:M00916 Factor: CREB; motif: NNTKACGTCANNNS 0.00421628088520911 5889 15 13 0.866666666666667 0.0022075055187638
TF TF:M00179 Factor: ATF2; motif: VGTGACGTMACN 0.00494795652923149 6065 15 13 0.866666666666667 0.0021434460016488
TF TF:M09866_1 Factor: ATF-1; motif: NNRTGACGYMA; match class: 1 0.00494795652923149 955 8 5 0.625 0.00523560209424084
TF TF:M01861_1 Factor: ATF-1; motif: TNACGTCAN; match class: 1 0.00494795652923149 1896 14 8 0.571428571428571 0.00421940928270042
TF TF:M09632 Factor: Kaiso; motif: GNTCTCGCGAGRNNNNGGN 0.00533168644052869 3001 126 38 0.301587301587302 0.0126624458513829
TF TF:M01864_1 Factor: ATF-4; motif: KACGTCAKS; match class: 1 0.00533168644052869 1239 15 7 0.466666666666667 0.00564971751412429
TF TF:M00041_1 Factor: ATF2:c-Jun; motif: TGACGTYA; match class: 1 0.00545103315245866 1219 7 5 0.714285714285714 0.00410172272354389
TF TF:M11217_1 Factor: CREB1; motif: NRTGACGYN; match class: 1 0.00567616097795617 457 8 4 0.5 0.0087527352297593
TF TF:M11217 Factor: CREB1; motif: NRTGACGYN 0.00654968898342077 2783 14 9 0.642857142857143 0.00323392022996766
TF TF:M00338_1 Factor: ATF; motif: NTGACGTCANYS; match class: 1 0.00683198878597947 1122 8 5 0.625 0.00445632798573975
TF TF:M09600 Factor: CREB1; motif: TKACGTCAYNN 0.00683198878597947 5324 8 8 1 0.00150262960180316
TF TF:M00178 Factor: CREB; motif: NSTGACGTMANN 0.00683198878597947 5255 8 8 1 0.00152235965746908
TF TF:M07248 Factor: CREB1; motif: NNNNTGACGTNANNN 0.00683198878597947 4266 15 11 0.733333333333333 0.00257852789498359
TF TF:M07034 Factor: ATF-1; motif: NNNTGACGTNNN 0.00683198878597947 4248 15 11 0.733333333333333 0.0025894538606403
TF TF:M09592 Factor: ATF-1; motif: NRTGACGTMAN 0.00698649674780311 4411 17 12 0.705882352941177 0.00272047154840172
TF TF:M09887 Factor: CREB1; motif: NRRTGACGTMA 0.00719129871562114 5419 8 8 1 0.00147628713784831
TF TF:M07312 Factor: ATF-2; motif: NNTGACGTCAN 0.00756925443782417 3483 8 7 0.875 0.00200976169968418
TF TF:M07034_1 Factor: ATF-1; motif: NNNTGACGTNNN; match class: 1 0.00756925443782417 1179 8 5 0.625 0.00424088210347752
TF TF:M09600_1 Factor: CREB1; motif: TKACGTCAYNN; match class: 1 0.00777085147289708 1552 14 7 0.5 0.00451030927835052
TF TF:M00017 Factor: ATF; motif: CNSTGACGTNNNYC 0.00792695370903701 7226 16 14 0.875 0.00193744810406864
TF TF:M00152 Factor: SRF; motif: ATGCCCATATATGGWNNT 0.00792886565930285 182 8 3 0.375 0.0164835164835165
TF TF:M00917 Factor: CREB; motif: CNNTGACGTMA 0.00881334818998125 5578 15 12 0.8 0.00215130871280029
TF TF:M09592_1 Factor: ATF-1; motif: NRTGACGTMAN; match class: 1 0.00882244121013324 1255 8 5 0.625 0.00398406374501992
TF TF:M12057 Factor: ZBP99; motif: GCCCMTCCCCCR 0.00955766237917124 5225 67 33 0.492537313432836 0.00631578947368421
TF TF:M01820 Factor: CREM; motif: TGACGTCASYN 0.0116293751519334 6303 16 13 0.8125 0.00206250991591306
TF TF:M00338 Factor: ATF; motif: NTGACGTCANYS 0.0129168603445419 3798 15 10 0.666666666666667 0.00263296471827278
TF TF:M11697_1 Factor: MEF-2B1; motif: CCNWATWNRG; match class: 1 0.0139820986521687 683 8 4 0.5 0.00585651537335286
TF TF:M00694 Factor: E4F1; motif: SYTACGTCAC 0.0139820986521687 152 59 5 0.0847457627118644 0.0328947368421053
TF TF:M00691_1 Factor: ATF-1; motif: CYYTGACGTCA; match class: 1 0.015754002102732 854 7 4 0.571428571428571 0.00468384074941452
TF TF:M00039_1 Factor: CREB; motif: TGACGTMA; match class: 1 0.015754002102732 1482 8 5 0.625 0.00337381916329285
TF TF:M03544 Factor: CREB1; motif: NNNNACGTCANN 0.015754002102732 4101 8 7 0.875 0.00170690075591319
TF TF:M00687 Factor: alpha-CP1; motif: CAGCCAATGAG 0.0170910448431099 2326 65 19 0.292307692307692 0.00816852966466036
TF TF:M02106 Factor: NF-YA; motif: CRGCCAATCAGNRN 0.017359254261313 1741 65 16 0.246153846153846 0.00919012062033314
TF TF:M01820_1 Factor: CREM; motif: TGACGTCASYN; match class: 1 0.0174702877524363 1879 7 5 0.714285714285714 0.00266098988823842
TF TF:M00032 Factor: c-Ets-1(p54); motif: NCMGGAWGYN 0.0174702877524363 7858 13 12 0.923076923076923 0.0015271061338763
TF TF:M01118_1 Factor: WT1; motif: SMCNCCNSC; match class: 1 0.0174702877524363 2766 20 10 0.5 0.00361532899493854
TF TF:M08993_1 Factor: ZNF777; motif: GTCCGYCCCGTCSAACAAT; match class: 1 0.0174702877524363 4112 125 44 0.352 0.0107003891050584
TF TF:M01863 Factor: ATF-3; motif: RTKRCGTCANN 0.0174702877524363 1885 14 7 0.5 0.00371352785145889
TF TF:M00050 Factor: E2F; motif: TTTSGCGC 0.0187967663075682 7056 44 28 0.636363636363636 0.00396825396825397
TF TF:M11695 Factor: MEF-2D; motif: CCAWATWTRG 0.0195030316222117 288 8 3 0.375 0.0104166666666667
TF TF:M01219_1 Factor: SP1:SP3; motif: CCSCCCCCYCC; match class: 1 0.0210981799840867 2937 50 18 0.36 0.00612870275791624
TF TF:M00177 Factor: CREB; motif: NSTGACGTAANN 0.0210981799840867 5221 17 12 0.705882352941177 0.00229841026623252
TF TF:M02090_1 Factor: E2F-4; motif: GCGGGAAANA; match class: 1 0.0210981799840867 6378 125 60 0.48 0.00940733772342427
TF TF:M00039 Factor: CREB; motif: TGACGTMA 0.0223329723427946 5222 15 11 0.733333333333333 0.00210647261585599
TF TF:M11231 Factor: CREBL1; motif: GRTGACGTCAYC 0.0275222667394799 1057 7 4 0.571428571428571 0.00378429517502365
TF TF:M11696_1 Factor: MEF-2B1; motif: CCNWATWWRG; match class: 1 0.0277033646990902 898 8 4 0.5 0.0044543429844098
TF TF:M07481 Factor: TEF1; motif: GGAATGYRWGGWATG 0.0301615550015836 232 50 5 0.1 0.021551724137931
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.0301615550015836 10253 126 85 0.674603174603175 0.00829025651028967
TF TF:M11085 Factor: SREBP-2; motif: ATCACGTGAY 0.0301615550015836 3911 5 5 1 0.00127844541038098
TF TF:M11541 Factor: Foxn2; motif: NNGCGTCNNNNNGACGCNN 0.0301615550015836 5751 51 27 0.529411764705882 0.00469483568075117
TF TF:M01199 Factor: RNF96; motif: BCCCGCRGCC 0.0301615550015836 8473 50 34 0.68 0.00401274637082497
TF TF:M11254 Factor: AIBZIP; motif: GRTGAYGTCAYC 0.0314429439488347 1132 7 4 0.571428571428571 0.00353356890459364
TF TF:M02281 Factor: SP1; motif: CCCCKCCCCC 0.0314429439488347 6480 67 36 0.537313432835821 0.00555555555555556
TF TF:M10529 Factor: Sp1; motif: RGGGMGGRGSNGGGG 0.0345470153279707 6891 98 51 0.520408163265306 0.00740095777100566
TF TF:M01862 Factor: ATF-2; motif: NNNTGACGTNAN 0.0366471937110998 3230 8 6 0.75 0.00185758513931889
TF TF:M00738 Factor: E2F-4:DP-1; motif: TTTSGCGC 0.0372025849551479 9812 109 72 0.660550458715596 0.00733795352629433
TF TF:M07312_1 Factor: ATF-2; motif: NNTGACGTCAN; match class: 1 0.0372025849551479 1070 13 5 0.384615384615385 0.00467289719626168
TF TF:M11285_1 Factor: Fra-1; motif: GRTGACGTCATC; match class: 1 0.0376055965311418 4589 15 10 0.666666666666667 0.00217912399215515
TF TF:M07246_1 Factor: ATF-4; motif: NNTKRCRTCANS; match class: 1 0.0379467875599403 584 34 6 0.176470588235294 0.0102739726027397
TF TF:M11308_1 Factor: ATF-2; motif: NRTGAYGTMAYN; match class: 1 0.037993679523075 1225 7 4 0.571428571428571 0.00326530612244898
TF TF:M08930 Factor: JUND:FRA-1; motif: RTGACGTMAY 0.037993679523075 5702 17 12 0.705882352941177 0.00210452472816556
TF TF:M05444_1 Factor: CPBP; motif: NGGGCGG; match class: 1 0.0433150028090307 3313 125 36 0.288 0.0108662843344401
TF TF:M11697 Factor: MEF-2B1; motif: CCNWATWNRG 0.0433150028090307 1096 8 4 0.5 0.00364963503649635
TF TF:M05361_1 Factor: Sp6; motif: WGGGCGG; match class: 1 0.0433150028090307 3313 125 36 0.288 0.0108662843344401
TF TF:M05332_1 Factor: Sp2; motif: WGGGCGG; match class: 1 0.0433150028090307 3313 125 36 0.288 0.0108662843344401
TF TF:M00981 Factor: CREB,; motif: NTGACGTNA 0.0433150028090307 8345 15 13 0.866666666666667 0.00155781905332534
TF TF:M08461 Factor: Erm:EVX1; motif: NNCGGAAATKR 0.0433150028090307 3396 59 21 0.355932203389831 0.00618374558303887
TF TF:M00041 Factor: ATF2:c-Jun; motif: TGACGTYA 0.0433150028090307 4294 9 7 0.777777777777778 0.0016301816488123
TF TF:M11883_1 Factor: pax-6; motif: NYACGCNTSRNYGCNYN; match class: 1 0.0439124518294373 7768 8 8 1 0.00102986611740474
TF TF:M07611_1 Factor: p54NRB; motif: GRNNNMGGATGRMNNCGGA; match class: 1 0.0439124518294373 1645 3 3 1 0.00182370820668693
TF TF:M09868_1 Factor: ATF-3; motif: GGTSACGTGAN; match class: 1 0.044395616294848 2116 8 5 0.625 0.00236294896030246
TF TF:M07397 Factor: ZBP89; motif: CCCCKCCCCCNN 0.0449475983712224 7143 42 26 0.619047619047619 0.00363992720145597
TF TF:M11877_1 Factor: pax-2; motif: NCGTCACGCNYSRNYGCNYN; match class: 1 0.0449475983712224 5304 8 7 0.875 0.00131975867269985
TF TF:M04390_1 Factor: LHX9; motif: NYAATTAN; match class: 1 0.0454658352118208 63 53 3 0.0566037735849057 0.0476190476190476
TF TF:M03544_1 Factor: CREB1; motif: NNNNACGTCANN; match class: 1 0.0454658352118208 1196 13 5 0.384615384615385 0.00418060200668896
TF TF:M05660 Factor: ZNF286B; motif: NTTGGCGGATGM 0.0454658352118208 51 67 3 0.0447761194029851 0.0588235294117647
TF TF:M12313 Factor: ZNF460; motif: NNACNCCCCCCNN 0.0454658352118208 5825 6 6 1 0.00103004291845494
TF TF:M12005_1 Factor: GMEB-1; motif: KNACGTNRNNACGTAN; match class: 1 0.0454658352118208 471 8 3 0.375 0.00636942675159236
TF TF:M00939 Factor: E2F; motif: TTTSGCGSG 0.0454658352118208 6433 106 51 0.481132075471698 0.00792787191046168
TF TF:M07354_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0454658352118208 3561 50 19 0.38 0.0053355798932884
TF TF:M10817 Factor: HOXC11; motif: NGTCGTAAANN 0.0454658352118208 566 84 9 0.107142857142857 0.0159010600706714
TF TF:M04439_1 Factor: SHOX2; motif: NYAATTAN; match class: 1 0.0454658352118208 63 53 3 0.0566037735849057 0.0476190476190476
TF TF:M08878_1 Factor: EGR; motif: CGCCCCCGCNN; match class: 1 0.0454658352118208 3224 67 22 0.328358208955224 0.00682382133995037
TF TF:M10112_1 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 0.0467605207381054 4075 20 11 0.55 0.00269938650306748
TF TF:M08472_1 Factor: Fli-1:E2A; motif: NCCGGAWRCASCTGN; match class: 1 0.0467605207381054 2240 5 4 0.8 0.00178571428571429
TF TF:M07248_1 Factor: CREB1; motif: NNNNTGACGTNANNN; match class: 1 0.0467605207381054 1216 13 5 0.384615384615385 0.00411184210526316
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.0467605207381054 8031 8 8 1 0.000996139957664052
WP WP:WP4877 Host-pathogen interaction of human corona viruses - MAPK signaling 8.94161465198643e-05 36 4 3 0.75 0.0833333333333333
WP WP:WP366 TGF-beta Signaling Pathway 0.000100478703665773 133 6 4 0.666666666666667 0.0300751879699248
WP WP:WP3611 Photodynamic therapy-induced AP-1 survival signaling. 0.000100478703665773 51 4 3 0.75 0.0588235294117647
WP WP:WP3527 Preimplantation Embryo 0.000272836370214583 60 38 5 0.131578947368421 0.0833333333333333
WP WP:WP286 IL-3 Signaling Pathway 0.000315330633501395 49 9 3 0.333333333333333 0.0612244897959184
WP WP:WP2374 Oncostatin M Signaling Pathway 0.000315330633501395 66 19 4 0.210526315789474 0.0606060606060606
WP WP:WP2840 Hair Follicle Development: Cytodifferentiation - Part 3 of 3 0.000337922337837443 89 6 3 0.5 0.0337078651685393
WP WP:WP2355 Corticotropin-releasing hormone signaling pathway 0.000337922337837443 91 6 3 0.5 0.032967032967033
WP WP:WP2032 Human Thyroid Stimulating Hormone (TSH) signaling pathway 0.000371116156248285 68 8 3 0.375 0.0441176470588235
WP WP:WP4659 Gastrin Signaling Pathway 0.00109111857908121 114 19 4 0.210526315789474 0.0350877192982456
WP WP:WP437 EGF/EGFR Signaling Pathway 0.00121434381279244 163 6 3 0.5 0.0184049079754601
WP WP:WP382 MAPK Signaling Pathway 0.00200031996343969 249 5 3 0.6 0.0120481927710843
WP WP:WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway 0.00203454960983112 144 8 3 0.375 0.0208333333333333
WP WP:WP2431 Spinal Cord Injury 0.00213197902407734 118 10 3 0.3 0.0254237288135593
WP WP:WP4149 White fat cell differentiation 0.00277246643314748 33 38 3 0.0789473684210526 0.0909090909090909
WP WP:WP2882 Nuclear Receptors Meta-Pathway 0.00390349519498946 321 11 4 0.363636363636364 0.0124610591900312
WP WP:WP2637 Structural Pathway of Interleukin 1 (IL-1) 0.0118252868770804 50 44 3 0.0681818181818182 0.06
WP WP:WP411 mRNA Processing 0.0122177722302049 133 57 5 0.087719298245614 0.037593984962406

pMA01 transcription factor target enrichment of top program genes

TF enrichment of pMA01
TFs corrosponding to activation of pMA01. (Left) pearson correlation of TF expression and gene expression program activatity in Mast cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.