pEpi36 program activity among Epithelial cells

Activation of pEpi36
pEpi36 gene program activation in Epithelial cells. (Top) Activation of program across all epithelial cells. (Bottom) Activation in MMRd (left), MMRp (middle), and normal epithelial cells (right).

Epithelial cell compositional overview

Overview of epithelial cell composition
Overview of epithelial cell composition. A tSNE plot colored by: (left) MMR status of epithelial cells, (middle) specimen, (righ) epithelial cell sub-type.
Gene program activation of pEpi36 by different cell subtypes
pEpi36 gene program activation among cells of different subtypes (Epithelial cells).

pEpi36 top program genes

Top genes of pEpi36 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pEpi36 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pEpi36
pEpi36 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0097435 supramolecular fiber organization 7.21381933734418e-08 734 21 11 0.523809523809524 0.0149863760217984
GO:BP GO:0030036 actin cytoskeleton organization 7.21381933734418e-08 709 21 11 0.523809523809524 0.0155148095909732
GO:BP GO:0030029 actin filament-based process 1.33989140368508e-07 808 21 11 0.523809523809524 0.0136138613861386
GO:BP GO:0007010 cytoskeleton organization 2.62374342621567e-06 1423 21 12 0.571428571428571 0.0084328882642305
GO:BP GO:0110053 regulation of actin filament organization 4.58690345968694e-06 284 21 7 0.333333333333333 0.0246478873239437
GO:BP GO:0007015 actin filament organization 4.58690345968694e-06 445 21 8 0.380952380952381 0.0179775280898876
GO:BP GO:0031032 actomyosin structure organization 5.11611676622099e-06 199 18 6 0.333333333333333 0.0301507537688442
GO:BP GO:0032956 regulation of actin cytoskeleton organization 1.95264197702446e-05 366 21 7 0.333333333333333 0.0191256830601093
GO:BP GO:1902903 regulation of supramolecular fiber organization 2.53622868012494e-05 387 21 7 0.333333333333333 0.0180878552971576
GO:BP GO:0032970 regulation of actin filament-based process 3.1592532467365e-05 406 21 7 0.333333333333333 0.0172413793103448
GO:BP GO:0072659 protein localization to plasma membrane 3.46036945303573e-05 283 5 4 0.8 0.0141342756183746
GO:BP GO:1990778 protein localization to cell periphery 5.96393812424212e-05 338 5 4 0.8 0.0118343195266272
GO:BP GO:0070527 platelet aggregation 6.20880799804658e-05 64 20 4 0.2 0.0625
GO:BP GO:0045214 sarcomere organization 7.88930176251998e-05 41 9 3 0.333333333333333 0.0731707317073171
GO:BP GO:0022610 biological adhesion 9.14737741681784e-05 1499 20 10 0.5 0.0066711140760507
GO:BP GO:0007155 cell adhesion 9.14737741681784e-05 1492 20 10 0.5 0.00670241286863271
GO:BP GO:0051493 regulation of cytoskeleton organization 9.96641978231298e-05 531 21 7 0.333333333333333 0.0131826741996234
GO:BP GO:0030833 regulation of actin filament polymerization 9.96641978231298e-05 177 21 5 0.238095238095238 0.0282485875706215
GO:BP GO:0034109 homotypic cell-cell adhesion 0.000119220806991146 87 20 4 0.2 0.0459770114942529
GO:BP GO:0030041 actin filament polymerization 0.000119220806991146 196 21 5 0.238095238095238 0.0255102040816327
GO:BP GO:0098609 cell-cell adhesion 0.000119220806991146 894 20 8 0.4 0.00894854586129754
GO:BP GO:0030832 regulation of actin filament length 0.000119220806991146 194 21 5 0.238095238095238 0.0257731958762887
GO:BP GO:0008064 regulation of actin polymerization or depolymerization 0.000119220806991146 193 21 5 0.238095238095238 0.0259067357512953
GO:BP GO:0009653 anatomical structure morphogenesis 0.000119220806991146 2797 9 8 0.888888888888889 0.00286020736503396
GO:BP GO:0051492 regulation of stress fiber assembly 0.000119220806991146 94 18 4 0.222222222222222 0.0425531914893617
GO:BP GO:0048013 ephrin receptor signaling pathway 0.000129877307891724 88 21 4 0.19047619047619 0.0454545454545455
GO:BP GO:0110020 regulation of actomyosin structure organization 0.000129877307891724 104 18 4 0.222222222222222 0.0384615384615385
GO:BP GO:0030239 myofibril assembly 0.000131383202960969 62 9 3 0.333333333333333 0.0483870967741935
GO:BP GO:0032231 regulation of actin filament bundle assembly 0.000131383202960969 106 18 4 0.222222222222222 0.0377358490566038
GO:BP GO:0030038 contractile actin filament bundle assembly 0.000138222117855136 109 18 4 0.222222222222222 0.036697247706422
GO:BP GO:0043149 stress fiber assembly 0.000138222117855136 109 18 4 0.222222222222222 0.036697247706422
GO:BP GO:0008154 actin polymerization or depolymerization 0.000176812309028956 223 21 5 0.238095238095238 0.0224215246636771
GO:BP GO:0032271 regulation of protein polymerization 0.000226578620963719 236 21 5 0.238095238095238 0.0211864406779661
GO:BP GO:0016192 vesicle-mediated transport 0.00028850825579166 2180 21 11 0.523809523809524 0.00504587155963303
GO:BP GO:0048468 cell development 0.00028850825579166 2100 9 7 0.777777777777778 0.00333333333333333
GO:BP GO:0072657 protein localization to membrane 0.000296093602820887 665 5 4 0.8 0.00601503759398496
GO:BP GO:0001738 morphogenesis of a polarized epithelium 0.000418586780406373 152 18 4 0.222222222222222 0.0263157894736842
GO:BP GO:0032989 cellular component morphogenesis 0.000489945273914252 791 9 5 0.555555555555556 0.00632111251580278
GO:BP GO:0010927 cellular component assembly involved in morphogenesis 0.000489945273914252 107 9 3 0.333333333333333 0.0280373831775701
GO:BP GO:0051017 actin filament bundle assembly 0.000489945273914252 161 18 4 0.222222222222222 0.0248447204968944
GO:BP GO:0055002 striated muscle cell development 0.00049385458475941 111 9 3 0.333333333333333 0.027027027027027
GO:BP GO:0060429 epithelium development 0.00049385458475941 1325 18 8 0.444444444444444 0.0060377358490566
GO:BP GO:0061572 actin filament bundle organization 0.00049385458475941 164 18 4 0.222222222222222 0.024390243902439
GO:BP GO:0070268 cornification 0.000497174064620982 112 9 3 0.333333333333333 0.0267857142857143
GO:BP GO:0042060 wound healing 0.000526812274178078 549 20 6 0.3 0.0109289617486339
GO:BP GO:0051258 protein polymerization 0.000542561792597887 305 21 5 0.238095238095238 0.0163934426229508
GO:BP GO:0071345 cellular response to cytokine stimulus 0.000552672563932624 1132 21 8 0.380952380952381 0.00706713780918728
GO:BP GO:0030154 cell differentiation 0.00060256402455554 4350 12 10 0.833333333333333 0.00229885057471264
GO:BP GO:0030168 platelet activation 0.00060256402455554 160 20 4 0.2 0.025
GO:BP GO:0051098 regulation of binding 0.000682350150836497 365 19 5 0.263157894736842 0.0136986301369863
GO:BP GO:0032233 positive regulation of actin filament bundle assembly 0.000682350150836497 64 18 3 0.166666666666667 0.046875
GO:BP GO:0090109 regulation of cell-substrate junction assembly 0.000682350150836497 64 18 3 0.166666666666667 0.046875
GO:BP GO:0007596 blood coagulation 0.000682350150836497 347 20 5 0.25 0.0144092219020173
GO:BP GO:0007599 hemostasis 0.000682350150836497 351 20 5 0.25 0.0142450142450142
GO:BP GO:0048869 cellular developmental process 0.000682350150836497 4428 12 10 0.833333333333333 0.0022583559168925
GO:BP GO:0051893 regulation of focal adhesion assembly 0.000682350150836497 64 18 3 0.166666666666667 0.046875
GO:BP GO:0050817 coagulation 0.000685691823790698 354 20 5 0.25 0.0141242937853107
GO:BP GO:0033043 regulation of organelle organization 0.000689495360385626 1203 21 8 0.380952380952381 0.00665004156275977
GO:BP GO:0034097 response to cytokine 0.000767096696759445 1226 21 8 0.380952380952381 0.0065252854812398
GO:BP GO:0150116 regulation of cell-substrate junction organization 0.000793431644016709 69 18 3 0.166666666666667 0.0434782608695652
GO:BP GO:0030837 negative regulation of actin filament polymerization 0.0008865248210277 68 19 3 0.157894736842105 0.0441176470588235
GO:BP GO:0009611 response to wounding 0.00118006397867804 674 20 6 0.3 0.00890207715133531
GO:BP GO:0032535 regulation of cellular component size 0.00121922756925369 388 21 5 0.238095238095238 0.0128865979381443
GO:BP GO:0048041 focal adhesion assembly 0.00134453100161247 85 18 3 0.166666666666667 0.0352941176470588
GO:BP GO:0055001 muscle cell development 0.00138502618243292 184 9 3 0.333333333333333 0.016304347826087
GO:BP GO:0032272 negative regulation of protein polymerization 0.00138502618243292 82 19 3 0.157894736842105 0.0365853658536585
GO:BP GO:0044087 regulation of cellular component biogenesis 0.00139131052741139 990 21 7 0.333333333333333 0.00707070707070707
GO:BP GO:1902905 positive regulation of supramolecular fiber organization 0.00155986552875813 214 21 4 0.19047619047619 0.0186915887850467
GO:BP GO:0001775 cell activation 0.00166827359846902 1495 20 8 0.4 0.00535117056856187
GO:BP GO:0045055 regulated exocytosis 0.00166827359846902 785 19 6 0.315789473684211 0.00764331210191083
GO:BP GO:0007044 cell-substrate junction assembly 0.00193039967226535 101 18 3 0.166666666666667 0.0297029702970297
GO:BP GO:0006996 organelle organization 0.00193039967226535 4104 21 13 0.619047619047619 0.00316764132553606
GO:BP GO:0051495 positive regulation of cytoskeleton organization 0.00193039967226535 231 21 4 0.19047619047619 0.0173160173160173
GO:BP GO:0150115 cell-substrate junction organization 0.00215487540190874 107 18 3 0.166666666666667 0.0280373831775701
GO:BP GO:0031424 keratinization 0.00215487540190874 224 9 3 0.333333333333333 0.0133928571428571
GO:BP GO:0043254 regulation of protein-containing complex assembly 0.00215487540190874 460 21 5 0.238095238095238 0.0108695652173913
GO:BP GO:0051641 cellular localization 0.00215487540190874 3541 21 12 0.571428571428571 0.00338887319966111
GO:BP GO:0016032 viral process 0.00247356401843395 942 18 6 0.333333333333333 0.00636942675159236
GO:BP GO:0050878 regulation of body fluid levels 0.00247356401843395 514 20 5 0.25 0.00972762645914397
GO:BP GO:0022607 cellular component assembly 0.00247356401843395 3010 21 11 0.523809523809524 0.00365448504983389
GO:BP GO:0030838 positive regulation of actin filament polymerization 0.00251841276643209 104 21 3 0.142857142857143 0.0288461538461538
GO:BP GO:0006887 exocytosis 0.00259018368588969 904 19 6 0.315789473684211 0.00663716814159292
GO:BP GO:0030335 positive regulation of cell migration 0.00260299214793088 567 19 5 0.263157894736842 0.00881834215167548
GO:BP GO:0001952 regulation of cell-matrix adhesion 0.00275421626672071 127 18 3 0.166666666666667 0.0236220472440945
GO:BP GO:0090066 regulation of anatomical structure size 0.0028039585908119 518 21 5 0.238095238095238 0.00965250965250965
GO:BP GO:2000147 positive regulation of cell motility 0.00295923098033772 591 19 5 0.263157894736842 0.00846023688663283
GO:BP GO:0044403 biological process involved in symbiotic interaction 0.00297811897025451 1001 18 6 0.333333333333333 0.00599400599400599
GO:BP GO:0051146 striated muscle cell differentiation 0.00317134234087146 289 9 3 0.333333333333333 0.0103806228373702
GO:BP GO:0051272 positive regulation of cellular component movement 0.00318820109101698 604 19 5 0.263157894736842 0.00827814569536424
GO:BP GO:0040017 positive regulation of locomotion 0.00318820109101698 606 19 5 0.263157894736842 0.00825082508250825
GO:BP GO:0007166 cell surface receptor signaling pathway 0.00318820109101698 3210 21 11 0.523809523809524 0.00342679127725857
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.00327472919024312 810 4 3 0.75 0.0037037037037037
GO:BP GO:0051099 positive regulation of binding 0.00343645517907426 174 15 3 0.2 0.0172413793103448
GO:BP GO:0044085 cellular component biogenesis 0.0034772210955771 3257 21 11 0.523809523809524 0.00337734111145226
GO:BP GO:0030855 epithelial cell differentiation 0.00353575056144194 798 23 6 0.260869565217391 0.0075187969924812
GO:BP GO:0030334 regulation of cell migration 0.00371633294039637 999 19 6 0.315789473684211 0.00600600600600601
GO:BP GO:0007043 cell-cell junction assembly 0.00385196993014333 151 18 3 0.166666666666667 0.0198675496688742
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 0.00403634030259313 147 19 3 0.157894736842105 0.0204081632653061
GO:BP GO:0009888 tissue development 0.00404352251220109 2107 14 7 0.5 0.00332225913621262
GO:BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 0.00405570351338467 135 21 3 0.142857142857143 0.0222222222222222
GO:BP GO:0061024 membrane organization 0.00405570351338467 973 8 4 0.5 0.00411099691675231
GO:BP GO:0002252 immune effector process 0.00405570351338467 1309 21 7 0.333333333333333 0.0053475935828877
GO:BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 0.00405570351338467 135 21 3 0.142857142857143 0.0222222222222222
GO:BP GO:0038094 Fc-gamma receptor signaling pathway 0.00420726006613412 137 21 3 0.142857142857143 0.0218978102189781
GO:BP GO:0010638 positive regulation of organelle organization 0.00428275741412857 603 21 5 0.238095238095238 0.00829187396351575
GO:BP GO:0032273 positive regulation of protein polymerization 0.0044104809410415 141 21 3 0.142857142857143 0.0212765957446809
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 0.0044104809410415 141 21 3 0.142857142857143 0.0212765957446809
GO:BP GO:2000145 regulation of cell motility 0.00441304053352832 1061 19 6 0.315789473684211 0.0056550424128181
GO:BP GO:0006936 muscle contraction 0.00473590410976982 364 20 4 0.2 0.010989010989011
GO:BP GO:0006928 movement of cell or subcellular component 0.0047735530584 2311 21 9 0.428571428571429 0.00389441800086543
GO:BP GO:0051674 localization of cell 0.00498563048629886 1828 21 8 0.380952380952381 0.00437636761487965
GO:BP GO:0048870 cell motility 0.00498563048629886 1828 21 8 0.380952380952381 0.00437636761487965
GO:BP GO:0051494 negative regulation of cytoskeleton organization 0.00505087393845706 166 19 3 0.157894736842105 0.0180722891566265
GO:BP GO:0040012 regulation of locomotion 0.00520294382209973 1104 19 6 0.315789473684211 0.00543478260869565
GO:BP GO:0034613 cellular protein localization 0.00521261828575632 2014 5 4 0.8 0.00198609731876862
GO:BP GO:1902904 negative regulation of supramolecular fiber organization 0.00525470817447828 170 19 3 0.157894736842105 0.0176470588235294
GO:BP GO:0070727 cellular macromolecule localization 0.00525470817447828 2024 5 4 0.8 0.00197628458498024
GO:BP GO:0034329 cell junction assembly 0.00530211488770833 438 8 3 0.375 0.00684931506849315
GO:BP GO:0016043 cellular component organization 0.00532229598423699 6566 10 9 0.9 0.00137069753274444
GO:BP GO:0042692 muscle cell differentiation 0.00548425642213242 390 9 3 0.333333333333333 0.00769230769230769
GO:BP GO:0051270 regulation of cellular component movement 0.00592446316079023 1141 19 6 0.315789473684211 0.00525854513584575
GO:BP GO:0032501 multicellular organismal process 0.0059971587957908 7946 23 18 0.782608695652174 0.00226529071230808
GO:BP GO:0010033 response to organic substance 0.00647434782528192 3412 22 11 0.5 0.00322391559202814
GO:BP GO:0071840 cellular component organization or biogenesis 0.00647434782528192 6760 10 9 0.9 0.00133136094674556
GO:BP GO:1901888 regulation of cell junction assembly 0.00670133925403608 202 18 3 0.166666666666667 0.0148514851485149
GO:BP GO:0006810 transport 0.00670133925403608 5224 8 7 0.875 0.00133996937212864
GO:BP GO:0048856 anatomical structure development 0.00702374182160376 6106 9 8 0.888888888888889 0.00131018670160498
GO:BP GO:0061061 muscle structure development 0.00720269031385989 645 23 5 0.217391304347826 0.00775193798449612
GO:BP GO:0043312 neutrophil degranulation 0.00725723165418879 482 18 4 0.222222222222222 0.00829875518672199
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00739021140464933 485 18 4 0.222222222222222 0.00824742268041237
GO:BP GO:0045216 cell-cell junction organization 0.00755810687096643 216 18 3 0.166666666666667 0.0138888888888889
GO:BP GO:0051234 establishment of localization 0.00755810687096643 5372 8 7 0.875 0.00130305286671631
GO:BP GO:0032879 regulation of localization 0.00786633646691117 2872 19 9 0.473684210526316 0.00313370473537604
GO:BP GO:0032502 developmental process 0.00786633646691117 6628 12 10 0.833333333333333 0.00150875075437538
GO:BP GO:0002446 neutrophil mediated immunity 0.00786633646691117 497 18 4 0.222222222222222 0.00804828973843058
GO:BP GO:0010810 regulation of cell-substrate adhesion 0.00788303722915227 222 18 3 0.166666666666667 0.0135135135135135
GO:BP GO:0042119 neutrophil activation 0.00788303722915227 498 18 4 0.222222222222222 0.00803212851405622
GO:BP GO:0042221 response to chemical 0.00788303722915227 4781 5 5 1 0.00104580631667015
GO:BP GO:0040011 locomotion 0.00788303722915227 2028 21 8 0.380952380952381 0.00394477317554241
GO:BP GO:0036230 granulocyte activation 0.00797827590172657 504 18 4 0.222222222222222 0.00793650793650794
GO:BP GO:0007165 signal transduction 0.00798280070633447 6309 9 8 0.888888888888889 0.00126802979870027
GO:BP GO:0007160 cell-matrix adhesion 0.00895679397117944 235 18 3 0.166666666666667 0.0127659574468085
GO:BP GO:0008104 protein localization 0.00895679397117944 2770 10 6 0.6 0.00216606498194946
GO:BP GO:0003012 muscle system process 0.00906017819266653 471 20 4 0.2 0.00849256900212314
GO:BP GO:0043299 leukocyte degranulation 0.00943214779817939 535 18 4 0.222222222222222 0.00747663551401869
GO:BP GO:0051179 localization 0.00993877672639979 6901 19 14 0.736842105263158 0.00202869149398638
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0100552140458762 547 18 4 0.222222222222222 0.00731261425959781
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0102407731871682 551 18 4 0.222222222222222 0.00725952813067151
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0102556270743545 1202 9 4 0.444444444444444 0.00332778702163062
GO:BP GO:0002009 morphogenesis of an epithelium 0.0107171119931468 560 18 4 0.222222222222222 0.00714285714285714
GO:BP GO:0007163 establishment or maintenance of cell polarity 0.0107416799692422 220 21 3 0.142857142857143 0.0136363636363636
GO:BP GO:0032940 secretion by cell 0.0110800082384449 1364 19 6 0.315789473684211 0.00439882697947214
GO:BP GO:0000904 cell morphogenesis involved in differentiation 0.0114686430106988 749 7 3 0.428571428571429 0.00400534045393859
GO:BP GO:0071310 cellular response to organic substance 0.0118694013376043 2776 21 9 0.428571428571429 0.00324207492795389
GO:BP GO:0023052 signaling 0.0120714081469593 6810 9 8 0.888888888888889 0.00117474302496329
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0121862762378309 2255 9 5 0.555555555555556 0.00221729490022173
GO:BP GO:0007154 cell communication 0.0121862762378309 6829 9 8 0.888888888888889 0.00117147459364475
GO:BP GO:0038093 Fc receptor signaling pathway 0.0124697234381707 238 21 3 0.142857142857143 0.0126050420168067
GO:BP GO:0140352 export from cell 0.0125987908041324 1418 19 6 0.315789473684211 0.00423131170662906
GO:BP GO:0051649 establishment of localization in cell 0.012701130857364 2813 21 9 0.428571428571429 0.00319943121222894
GO:BP GO:0048731 system development 0.0131990560903582 5052 9 7 0.777777777777778 0.00138558986539984
GO:BP GO:0050896 response to stimulus 0.0133090447208191 9407 9 9 1 0.000956734346763049
GO:BP GO:0006897 endocytosis 0.0133090447208191 696 8 3 0.375 0.00431034482758621
GO:BP GO:0006955 immune response 0.0143990153932959 2311 21 8 0.380952380952381 0.00346170488965816
GO:BP GO:0034330 cell junction organization 0.0144422642997292 722 8 3 0.375 0.00415512465373961
GO:BP GO:0070925 organelle assembly 0.0144684848982374 895 21 5 0.238095238095238 0.00558659217877095
GO:BP GO:0044089 positive regulation of cellular component biogenesis 0.0145741462308358 540 21 4 0.19047619047619 0.00740740740740741
GO:BP GO:0031334 positive regulation of protein-containing complex assembly 0.0152156540270426 263 21 3 0.142857142857143 0.0114068441064639
GO:BP GO:0046903 secretion 0.0154696116125848 1501 19 6 0.315789473684211 0.00399733510992672
GO:BP GO:0033036 macromolecule localization 0.0155488062268965 3218 10 6 0.6 0.00186451211932878
GO:BP GO:0048729 tissue morphogenesis 0.0164197593848802 667 18 4 0.222222222222222 0.00599700149925037
GO:BP GO:0002274 myeloid leukocyte activation 0.0164197593848802 667 18 4 0.222222222222222 0.00599700149925037
GO:BP GO:0010632 regulation of epithelial cell migration 0.0167826153099368 306 19 3 0.157894736842105 0.00980392156862745
GO:BP GO:0051128 regulation of cellular component organization 0.0173723809048906 2412 21 8 0.380952380952381 0.0033167495854063
GO:BP GO:0065008 regulation of biological quality 0.0203842293015325 4131 22 11 0.5 0.00266279351246672
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0204367415416802 717 18 4 0.222222222222222 0.00557880055788006
GO:BP GO:0002263 cell activation involved in immune response 0.0207780438620515 721 18 4 0.222222222222222 0.00554785020804438
GO:BP GO:0070887 cellular response to chemical stimulus 0.0216028290080419 3393 5 4 0.8 0.00117889773062187
GO:BP GO:0007275 multicellular organism development 0.0216028290080419 5613 9 7 0.777777777777778 0.00124710493497239
GO:BP GO:0031589 cell-substrate adhesion 0.0220334983761155 367 18 3 0.166666666666667 0.00817438692098093
GO:BP GO:0016477 cell migration 0.0221246506825672 1649 19 6 0.315789473684211 0.00363856882959369
GO:BP GO:0000902 cell morphogenesis 0.0224219858597935 1037 7 3 0.428571428571429 0.00289296046287367
GO:BP GO:0010639 negative regulation of organelle organization 0.0235308298180575 361 19 3 0.157894736842105 0.00831024930747922
GO:BP GO:0051716 cellular response to stimulus 0.0248576185144324 7781 9 8 0.888888888888889 0.00102814548258579
GO:BP GO:0010631 epithelial cell migration 0.0248576185144324 370 19 3 0.157894736842105 0.00810810810810811
GO:BP GO:0090132 epithelium migration 0.0252319655831708 373 19 3 0.157894736842105 0.00804289544235925
GO:BP GO:0090130 tissue migration 0.0259136848605545 379 19 3 0.157894736842105 0.0079155672823219
GO:BP GO:0048513 animal organ development 0.0261501453643793 3672 5 4 0.8 0.00108932461873638
GO:BP GO:0051129 negative regulation of cellular component organization 0.0264476689807367 759 19 4 0.210526315789474 0.00527009222661397
GO:BP GO:0034622 cellular protein-containing complex assembly 0.0273443833889497 1107 21 5 0.238095238095238 0.004516711833785
GO:BP GO:1901700 response to oxygen-containing compound 0.0274100503875849 1739 5 3 0.6 0.00172512938470385
GO:BP GO:0001503 ossification 0.0274432582645869 417 18 3 0.166666666666667 0.00719424460431655
GO:BP GO:0044093 positive regulation of molecular function 0.0274641672231995 1771 19 6 0.315789473684211 0.00338791643139469
GO:BP GO:0031346 positive regulation of cell projection organization 0.0279394315160018 359 21 3 0.142857142857143 0.00835654596100279
GO:BP GO:0051336 regulation of hydrolase activity 0.0279394315160018 1321 18 5 0.277777777777778 0.00378501135503407
GO:BP GO:0050808 synapse organization 0.0286206627216103 428 18 3 0.166666666666667 0.00700934579439252
GO:BP GO:0051049 regulation of transport 0.0294766257605239 1809 19 6 0.315789473684211 0.0033167495854063
GO:BP GO:0052548 regulation of endopeptidase activity 0.0300609617108743 437 18 3 0.166666666666667 0.0068649885583524
GO:BP GO:0051130 positive regulation of cellular component organization 0.0307816886727779 1153 21 5 0.238095238095238 0.00433651344319167
GO:BP GO:0006909 phagocytosis 0.0327484310124238 387 21 3 0.142857142857143 0.00775193798449612
GO:BP GO:0002443 leukocyte mediated immunity 0.0327484310124238 877 18 4 0.222222222222222 0.00456100342075257
GO:BP GO:0052547 regulation of peptidase activity 0.0343182759596387 467 18 3 0.166666666666667 0.00642398286937901
GO:BP GO:0050794 regulation of cellular process 0.0343182759596387 11473 10 10 1 0.000871611609866643
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.0343182759596387 760 21 4 0.19047619047619 0.00526315789473684
GO:BP GO:0002376 immune system process 0.0345879499974141 3278 22 9 0.409090909090909 0.00274557657107993
GO:BP GO:0007409 axonogenesis 0.0357532445818394 478 18 3 0.166666666666667 0.00627615062761506
GO:BP GO:0006950 response to stress 0.0367518187778834 4170 21 10 0.476190476190476 0.00239808153477218
GO:BP GO:0050790 regulation of catalytic activity 0.0367518187778834 2545 19 7 0.368421052631579 0.00275049115913556
GO:BP GO:0065009 regulation of molecular function 0.03697945962534 3221 19 8 0.421052631578947 0.00248370071406396
GO:BP GO:0043269 regulation of ion transport 0.0376881899490841 1379 19 5 0.263157894736842 0.00362581580855693
GO:BP GO:0001667 ameboidal-type cell migration 0.0428478182575535 494 19 3 0.157894736842105 0.00607287449392713
GO:BP GO:0061564 axon development 0.0428478182575535 523 18 3 0.166666666666667 0.00573613766730402
GO:BP GO:0009605 response to external stimulus 0.0452512536392161 2944 4 3 0.75 0.00101902173913043
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0485062060839213 477 21 3 0.142857142857143 0.00628930817610063
GO:BP GO:0002757 immune response-activating signal transduction 0.0485062060839213 477 21 3 0.142857142857143 0.00628930817610063
GO:BP GO:0050789 regulation of biological process 0.0492442024642586 12091 10 10 1 0.000827061450665784
GO:CC GO:1903561 extracellular vesicle 1.52531202561387e-12 2261 21 18 0.857142857142857 0.00796107916850951
GO:CC GO:0043230 extracellular organelle 1.52531202561387e-12 2263 21 18 0.857142857142857 0.00795404330534688
GO:CC GO:0070062 extracellular exosome 1.52531202561387e-12 2176 21 18 0.857142857142857 0.00827205882352941
GO:CC GO:0005615 extracellular space 1.39090100698538e-10 3594 21 19 0.904761904761905 0.00528658875904285
GO:CC GO:0005576 extracellular region 2.93138365291319e-10 4567 21 20 0.952380952380952 0.00437924239106635
GO:CC GO:0031982 vesicle 8.72166822956009e-10 4055 21 19 0.904761904761905 0.00468557336621455
GO:CC GO:0070161 anchoring junction 1.84148376597098e-07 836 21 10 0.476190476190476 0.0119617224880383
GO:CC GO:0005911 cell-cell junction 2.1957448741109e-07 494 8 6 0.75 0.0121457489878543
GO:CC GO:0005912 adherens junction 2.13861328147067e-06 173 6 4 0.666666666666667 0.023121387283237
GO:CC GO:0005856 cytoskeleton 2.18387512589238e-06 2332 21 13 0.619047619047619 0.0055746140651801
GO:CC GO:0005938 cell cortex 5.25371221733978e-06 311 18 6 0.333333333333333 0.0192926045016077
GO:CC GO:0015629 actin cytoskeleton 1.41643785908533e-05 513 21 7 0.333333333333333 0.01364522417154
GO:CC GO:0005829 cytosol 3.15204723631482e-05 5303 22 17 0.772727272727273 0.00320573260418631
GO:CC GO:0072562 blood microparticle 3.41970928575197e-05 140 14 4 0.285714285714286 0.0285714285714286
GO:CC GO:0005925 focal adhesion 5.45118453086024e-05 420 21 6 0.285714285714286 0.0142857142857143
GO:CC GO:0031252 cell leading edge 5.45118453086024e-05 422 21 6 0.285714285714286 0.014218009478673
GO:CC GO:0030055 cell-substrate junction 5.54110401254713e-05 427 21 6 0.285714285714286 0.0140515222482436
GO:CC GO:0099513 polymeric cytoskeletal fiber 0.000113328464801953 764 9 5 0.555555555555556 0.00654450261780105
GO:CC GO:0043228 non-membrane-bounded organelle 0.000167676407882659 5346 22 16 0.727272727272727 0.00299289188178077
GO:CC GO:0043232 intracellular non-membrane-bounded organelle 0.000167676407882659 5338 22 16 0.727272727272727 0.00299737729486699
GO:CC GO:0019897 extrinsic component of plasma membrane 0.000171374133846838 176 18 4 0.222222222222222 0.0227272727272727
GO:CC GO:0001726 ruffle 0.000176097133991361 179 18 4 0.222222222222222 0.0223463687150838
GO:CC GO:0005737 cytoplasm 0.000180378327672129 11911 23 23 1 0.00193098816220301
GO:CC GO:0042383 sarcolemma 0.000214923638173681 140 9 3 0.333333333333333 0.0214285714285714
GO:CC GO:0030054 cell junction 0.000214923638173681 2105 21 10 0.476190476190476 0.00475059382422803
GO:CC GO:0030016 myofibril 0.000214923638173681 231 16 4 0.25 0.0173160173160173
GO:CC GO:0099512 supramolecular fiber 0.000240453409311738 993 9 5 0.555555555555556 0.00503524672708963
GO:CC GO:0043292 contractile fiber 0.000240453409311738 240 16 4 0.25 0.0166666666666667
GO:CC GO:0099081 supramolecular polymer 0.000243372787295789 1001 9 5 0.555555555555556 0.004995004995005
GO:CC GO:0099080 supramolecular complex 0.00044664289215976 1323 17 7 0.411764705882353 0.00529100529100529
GO:CC GO:0005882 intermediate filament 0.000630438723730495 218 9 3 0.333333333333333 0.0137614678899083
GO:CC GO:0005884 actin filament 0.000637921285198804 118 16 3 0.1875 0.0254237288135593
GO:CC GO:0019898 extrinsic component of membrane 0.00074585488084298 313 7 3 0.428571428571429 0.00958466453674121
GO:CC GO:0034774 secretory granule lumen 0.00121254881077637 320 19 4 0.210526315789474 0.0125
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.00124373951390911 324 19 4 0.210526315789474 0.0123456790123457
GO:CC GO:0031983 vesicle lumen 0.00124616772916025 326 19 4 0.210526315789474 0.0122699386503067
GO:CC GO:0043296 apical junction complex 0.0014787974119546 145 18 3 0.166666666666667 0.0206896551724138
GO:CC GO:0062023 collagen-containing extracellular matrix 0.00156929142972585 421 7 3 0.428571428571429 0.00712589073634204
GO:CC GO:0005886 plasma membrane 0.0017428632087737 5681 9 8 0.888888888888889 0.00140820278120049
GO:CC GO:0071944 cell periphery 0.00213582049659456 6169 14 11 0.785714285714286 0.00178310909385638
GO:CC GO:0030017 sarcomere 0.00252971649690327 208 16 3 0.1875 0.0144230769230769
GO:CC GO:0031012 extracellular matrix 0.00310471303767393 562 7 3 0.428571428571429 0.00533807829181495
GO:CC GO:0030312 external encapsulating structure 0.00310471303767393 563 7 3 0.428571428571429 0.00532859680284192
GO:CC GO:0048471 perinuclear region of cytoplasm 0.00316387834580271 735 12 4 0.333333333333333 0.0054421768707483
GO:CC GO:0120025 plasma membrane bounded cell projection 0.00331517491841683 2229 8 5 0.625 0.00224315836698071
GO:CC GO:0042995 cell projection 0.00394636550255171 2330 8 5 0.625 0.00214592274678112
GO:CC GO:0030141 secretory granule 0.00417415944911669 851 19 5 0.263157894736842 0.00587544065804935
GO:CC GO:0030027 lamellipodium 0.00437473019552129 200 21 3 0.142857142857143 0.015
GO:CC GO:0032991 protein-containing complex 0.00617062500563513 5548 5 5 1 0.000901225666906993
GO:CC GO:0099503 secretory vesicle 0.00753401511237162 1020 19 5 0.263157894736842 0.00490196078431373
GO:CC GO:0005622 intracellular anatomical structure 0.00888108607784003 14790 23 23 1 0.00155510480054091
GO:CC GO:0043229 intracellular organelle 0.0181090497006138 12491 22 20 0.909090909090909 0.00160115283003763
GO:CC GO:0005634 nucleus 0.0201120595743107 7592 8 7 0.875 0.000922023182297155
GO:CC GO:0043233 organelle lumen 0.0224630488900182 5565 6 5 0.833333333333333 0.000898472596585804
GO:CC GO:0031974 membrane-enclosed lumen 0.0224630488900182 5565 6 5 0.833333333333333 0.000898472596585804
GO:CC GO:0043226 organelle 0.0248077480659604 14008 22 21 0.954545454545455 0.00149914334665905
GO:CC GO:0043227 membrane-bounded organelle 0.0266425459953732 12858 22 20 0.909090909090909 0.00155545185876497
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0320129340210393 11296 8 8 1 0.000708215297450425
GO:CC GO:0098590 plasma membrane region 0.0347918853836763 1240 9 3 0.333333333333333 0.00241935483870968
GO:CC GO:0098552 side of membrane 0.0374757208419641 619 18 3 0.166666666666667 0.00484652665589661
GO:CC GO:0098794 postsynapse 0.0396929311215386 639 18 3 0.166666666666667 0.00469483568075117
GO:CC GO:0016020 membrane 0.0405399641605328 9838 18 14 0.777777777777778 0.00142305346615166
GO:CC GO:0030424 axon 0.0410765938386918 660 18 3 0.166666666666667 0.00454545454545455
GO:CC GO:0070013 intracellular organelle lumen 0.0439295620211285 5402 5 4 0.8 0.000740466493891151
GO:CC GO:0031410 cytoplasmic vesicle 0.0459946708814036 2424 19 6 0.315789473684211 0.00247524752475248
GO:CC GO:0097708 intracellular vesicle 0.0459946708814036 2428 19 6 0.315789473684211 0.00247116968698517
GO:MF GO:0044548 S100 protein binding 7.65375504029223e-07 14 7 3 0.428571428571429 0.214285714285714
GO:MF GO:0048306 calcium-dependent protein binding 7.65375504029223e-07 82 7 4 0.571428571428571 0.0487804878048781
GO:MF GO:0098641 cadherin binding involved in cell-cell adhesion 7.65375504029223e-07 18 6 3 0.5 0.166666666666667
GO:MF GO:0045296 cadherin binding 3.12839999294889e-06 333 14 6 0.428571428571429 0.018018018018018
GO:MF GO:0008092 cytoskeletal protein binding 3.29684259768898e-06 996 23 10 0.434782608695652 0.0100401606425703
GO:MF GO:0098632 cell-cell adhesion mediator activity 8.60823863862098e-06 49 6 3 0.5 0.0612244897959184
GO:MF GO:0098631 cell adhesion mediator activity 1.23438713811247e-05 58 6 3 0.5 0.0517241379310345
GO:MF GO:0050839 cell adhesion molecule binding 2.53959874191316e-05 546 14 6 0.428571428571429 0.010989010989011
GO:MF GO:0003785 actin monomer binding 5.44970127834416e-05 30 19 3 0.157894736842105 0.1
GO:MF GO:0005200 structural constituent of cytoskeleton 7.02252346557498e-05 104 21 4 0.19047619047619 0.0384615384615385
GO:MF GO:0005509 calcium ion binding 7.9016806190064e-05 721 20 7 0.35 0.00970873786407767
GO:MF GO:0003779 actin binding 0.000134130904398583 448 23 6 0.260869565217391 0.0133928571428571
GO:MF GO:0042802 identical protein binding 0.000377304789792132 2067 8 6 0.75 0.00290275761973875
GO:MF GO:0005198 structural molecule activity 0.000760346898268723 698 21 6 0.285714285714286 0.00859598853868195
GO:MF GO:0042803 protein homodimerization activity 0.0103036925873676 676 7 3 0.428571428571429 0.00443786982248521
GO:MF GO:0051015 actin filament binding 0.0137690067736442 212 23 3 0.130434782608696 0.0141509433962264
GO:MF GO:0044877 protein-containing complex binding 0.0173693212090675 1287 23 6 0.260869565217391 0.00466200466200466
GO:MF GO:0005515 protein binding 0.0185833638856503 14767 23 23 1 0.00155752691812826
GO:MF GO:0046983 protein dimerization activity 0.0221428929389192 1069 7 3 0.428571428571429 0.00280636108512629
GO:MF GO:0043167 ion binding 0.0486938209526028 6057 21 12 0.571428571428571 0.00198117880138683
HP HP:0030163 Abnormal vascular physiology 0.0174106148362664 248 8 4 0.5 0.0161290322580645
HPA HPA:0291163 liver; cholangiocytes[High] 0.000599873364216276 294 9 5 0.555555555555556 0.0170068027210884
HPA HPA:0381192 placenta; cytotrophoblasts[≥Medium] 0.0181301868815518 272 5 3 0.6 0.0110294117647059
HPA HPA:0291162 liver; cholangiocytes[≥Medium] 0.0181301868815518 1910 9 7 0.777777777777778 0.00366492146596859
HPA HPA:0381191 placenta; cytotrophoblasts[≥Low] 0.0187354428739459 303 5 3 0.6 0.0099009900990099
HPA HPA:0381211 placenta; syncytiotrophoblasts - cell body[≥Low] 0.0270809758496939 370 5 3 0.6 0.00810810810810811
KEGG KEGG:05132 Salmonella infection 3.11828312712523e-07 249 21 9 0.428571428571429 0.036144578313253
KEGG KEGG:04810 Regulation of actin cytoskeleton 1.15601048205847e-06 216 21 8 0.380952380952381 0.037037037037037
KEGG KEGG:05131 Shigellosis 3.96475343530199e-05 246 21 7 0.333333333333333 0.0284552845528455
KEGG KEGG:04530 Tight junction 5.25424593602783e-05 169 21 6 0.285714285714286 0.0355029585798817
KEGG KEGG:04670 Leukocyte transendothelial migration 8.71556845382102e-05 114 20 5 0.25 0.043859649122807
KEGG KEGG:04611 Platelet activation 0.000109650018462075 124 20 5 0.25 0.0403225806451613
KEGG KEGG:05100 Bacterial invasion of epithelial cells 0.000371260805220736 77 21 4 0.19047619047619 0.051948051948052
KEGG KEGG:04510 Focal adhesion 0.000821399800651467 200 20 5 0.25 0.025
KEGG KEGG:05135 Yersinia infection 0.00263036167947253 136 21 4 0.19047619047619 0.0294117647058824
KEGG KEGG:04520 Adherens junction 0.00307922610985133 71 18 3 0.166666666666667 0.0422535211267606
KEGG KEGG:05410 Hypertrophic cardiomyopathy 0.00390759300327715 90 16 3 0.1875 0.0333333333333333
KEGG KEGG:05414 Dilated cardiomyopathy 0.00419456834035921 95 16 3 0.1875 0.0315789473684211
KEGG KEGG:04015 Rap1 signaling pathway 0.00467933225434687 210 18 4 0.222222222222222 0.019047619047619
KEGG KEGG:05130 Pathogenic Escherichia coli infection 0.00583974503671251 196 21 4 0.19047619047619 0.0204081632653061
KEGG KEGG:05418 Fluid shear stress and atherosclerosis 0.0110573330010165 138 18 3 0.166666666666667 0.0217391304347826
KEGG KEGG:04921 Oxytocin signaling pathway 0.0136244230143403 154 18 3 0.166666666666667 0.0194805194805195
KEGG KEGG:04360 Axon guidance 0.0225435134082519 181 20 3 0.15 0.0165745856353591
KEGG KEGG:05205 Proteoglycans in cancer 0.0225435134082519 205 18 3 0.166666666666667 0.0146341463414634
KEGG KEGG:05014 Amyotrophic lateral sclerosis 0.0436196788300102 363 14 3 0.214285714285714 0.00826446280991736
REAC REAC:R-HSA-2682334 EPH-Ephrin signaling 2.33669638551036e-06 90 21 6 0.285714285714286 0.0666666666666667
REAC REAC:R-HSA-445355 Smooth Muscle Contraction 4.86866351828227e-05 38 20 4 0.2 0.105263157894737
REAC REAC:R-HSA-3928662 EPHB-mediated forward signaling 4.93854018729081e-05 40 21 4 0.19047619047619 0.1
REAC REAC:R-HSA-195258 RHO GTPase Effectors 0.000333469316331934 283 21 6 0.285714285714286 0.0212014134275618
REAC REAC:R-HSA-1266738 Developmental Biology 0.000333469316331934 1069 21 10 0.476190476190476 0.00935453695042095
REAC REAC:R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 0.000694136569238385 35 21 3 0.142857142857143 0.0857142857142857
REAC REAC:R-HSA-422475 Axon guidance 0.000894449968571942 549 21 7 0.333333333333333 0.0127504553734062
REAC REAC:R-HSA-5663220 RHO GTPases Activate Formins 0.000913321286517608 136 18 4 0.222222222222222 0.0294117647058824
REAC REAC:R-HSA-9675108 Nervous system development 0.000913321286517608 574 21 7 0.333333333333333 0.0121951219512195
REAC REAC:R-HSA-109582 Hemostasis 0.000959153974593337 657 19 7 0.368421052631579 0.0106544901065449
REAC REAC:R-HSA-9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 0.00104501484965428 413 21 6 0.285714285714286 0.0145278450363196
REAC REAC:R-HSA-194315 Signaling by Rho GTPases 0.00104501484965428 413 21 6 0.285714285714286 0.0145278450363196
REAC REAC:R-HSA-6809371 Formation of the cornified envelope 0.00119549541181562 128 9 3 0.333333333333333 0.0234375
REAC REAC:R-HSA-397014 Muscle contraction 0.00233014691668264 205 20 4 0.2 0.0195121951219512
REAC REAC:R-HSA-4420097 VEGFA-VEGFR2 Pathway 0.00233014691668264 94 18 3 0.166666666666667 0.0319148936170213
REAC REAC:R-HSA-194138 Signaling by VEGF 0.00262487859515514 104 18 3 0.166666666666667 0.0288461538461538
REAC REAC:R-HSA-76002 Platelet activation, signaling and aggregation 0.00345016896617568 258 19 4 0.210526315789474 0.0155038759689922
REAC REAC:R-HSA-9664407 Parasite infection 0.00421331086737417 113 21 3 0.142857142857143 0.0265486725663717
REAC REAC:R-HSA-9664417 Leishmania phagocytosis 0.00421331086737417 113 21 3 0.142857142857143 0.0265486725663717
REAC REAC:R-HSA-9664422 FCGR3A-mediated phagocytosis 0.00421331086737417 113 21 3 0.142857142857143 0.0265486725663717
REAC REAC:R-HSA-114608 Platelet degranulation 0.00421331086737417 125 19 3 0.157894736842105 0.024
REAC REAC:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.00445084325427842 116 21 3 0.142857142857143 0.0258620689655172
REAC REAC:R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 0.00448596442233667 130 19 3 0.157894736842105 0.0230769230769231
REAC REAC:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.00704669878979089 140 21 3 0.142857142857143 0.0214285714285714
REAC REAC:R-HSA-8856828 Clathrin-mediated endocytosis 0.00749221531130809 144 21 3 0.142857142857143 0.0208333333333333
REAC REAC:R-HSA-168249 Innate Immune System 0.00932981609630238 1073 21 7 0.333333333333333 0.0065237651444548
REAC REAC:R-HSA-6798695 Neutrophil degranulation 0.0173003823666578 474 18 4 0.222222222222222 0.00843881856540084
REAC REAC:R-HSA-1280215 Cytokine Signaling in Immune system 0.0377472178256073 842 8 3 0.375 0.00356294536817102
TF TF:M09971 Factor: GKLF; motif: WGGGYGKGGC 0.000282240403778276 5546 21 18 0.857142857142857 0.00324558240173098
TF TF:M02076 Factor: Spi-B; motif: NGNGGAAGYN 0.00180665115498227 303 6 4 0.666666666666667 0.0132013201320132
TF TF:M09963 Factor: JunB; motif: NNTGAGTCANN 0.00497652107535924 905 4 4 1 0.00441988950276243
TF TF:M01007 Factor: SRF; motif: CNKNKCCTTATWTGGNNNN 0.00526372762371399 256 23 5 0.217391304347826 0.01953125
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.00526372762371399 10494 23 22 0.956521739130435 0.00209643605870021
TF TF:M09871 Factor: bach2; motif: TGCTGAGTCAN 0.00526372762371399 395 3 3 1 0.00759493670886076
TF TF:M08662_1 Factor: AP-2gamma:HES-7; motif: NNCACGYGNNNNNNSCCNNNGGS; match class: 1 0.00608535563075765 220 5 3 0.6 0.0136363636363636
TF TF:M09593 Factor: Bach1; motif: TGCTGAGTCANNS 0.00759159975661976 536 3 3 1 0.00559701492537313
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.00759159975661976 8944 21 19 0.904761904761905 0.00212432915921288
TF TF:M03876_1 Factor: Kaiso; motif: GCMGGGRGCRGS; match class: 1 0.0095915470462826 9106 21 19 0.904761904761905 0.00208653634965957
TF TF:M09734_1 Factor: ZNF692; motif: SYNGGSCCCASCCNC; match class: 1 0.0100318297745317 6255 19 15 0.789473684210526 0.00239808153477218
TF TF:M09972 Factor: BTEB2; motif: WGGGTGKGGCNGGN 0.0102690824574358 9217 21 19 0.904761904761905 0.0020614082673321
TF TF:M08929 Factor: JUND:FRA-1; motif: NRTGACTCAN 0.0110149197702419 1560 4 4 1 0.00256410256410256
TF TF:M07114 Factor: c-MAF:NF-E2p45; motif: ATGACTCAGCANWTN 0.0127680286796113 745 3 3 1 0.00402684563758389
TF TF:M11297_1 Factor: jdp2; motif: NRTGASTCAYN; match class: 1 0.0127680286796113 1667 4 4 1 0.0023995200959808
TF TF:M07091 Factor: Fra-1; motif: RRTGASTCAKN 0.0129060735035135 1716 4 4 1 0.00233100233100233
TF TF:M10076 Factor: SRF; motif: TTNCCWTWTWTGGNCWNN 0.0129492705996306 187 23 4 0.173913043478261 0.0213903743315508
TF TF:M09923_1 Factor: Fra-2; motif: NNRTGAGTCAYN; match class: 1 0.0136183570291238 614 4 3 0.75 0.00488599348534202
TF TF:M01870 Factor: C-ets-1; motif: AGGAAGN 0.0136183570291238 6837 21 16 0.761904761904762 0.00234020769343279
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.0136183570291238 3962 20 12 0.6 0.00302877334679455
TF TF:M04217 Factor: MAFK; motif: NAWWNTGCTGAS 0.0136183570291238 940 3 3 1 0.00319148936170213
TF TF:M12160 Factor: KLF15; motif: RCCMCRCCCMCN 0.0136183570291238 12729 21 21 1 0.00164977610181475
TF TF:M00983 Factor: MAF; motif: NGCTGAGTCAN 0.0136183570291238 6031 8 8 1 0.00132647985408722
TF TF:M03551_1 Factor: JunB; motif: TGACTCAN; match class: 1 0.0136183570291238 599 4 3 0.75 0.00500834724540901
TF TF:M09631 Factor: JunB; motif: NNNTGAGTCAY 0.0136183570291238 1915 4 4 1 0.002088772845953
TF TF:M01104 Factor: MOVO-B; motif: GNGGGGG 0.0136183570291238 10261 22 20 0.909090909090909 0.00194912776532502
TF TF:M09615_1 Factor: Fra-1; motif: NRTGACTCATN; match class: 1 0.0136183570291238 559 4 3 0.75 0.00536672629695885
TF TF:M10625 Factor: Nkx3-2; motif: NTCGTTAN 0.0136183570291238 6062 8 8 1 0.00131969646981194
TF TF:M02278 Factor: SPI1; motif: AGGAAGT 0.0136183570291238 6837 21 16 0.761904761904762 0.00234020769343279
TF TF:M07382 Factor: Fli-1; motif: MGGAAGT 0.0136183570291238 6837 21 16 0.761904761904762 0.00234020769343279
TF TF:M03579 Factor: PEA3; motif: AGGAAGT 0.0136183570291238 6837 21 16 0.761904761904762 0.00234020769343279
TF TF:M04711 Factor: PU.1; motif: ACTTCCTCT 0.0136183570291238 1712 7 5 0.714285714285714 0.00292056074766355
TF TF:M02280_1 Factor: AP1; motif: TGACTCA; match class: 1 0.0136183570291238 599 4 3 0.75 0.00500834724540901
TF TF:M07261 Factor: LKLF; motif: GGGGTGGKSN 0.0136183570291238 9774 17 16 0.941176470588235 0.00163699611213423
TF TF:M11297 Factor: jdp2; motif: NRTGASTCAYN 0.0136183570291238 1811 4 4 1 0.00220872446162341
TF TF:M09862 Factor: ZNF614; motif: NCYCWGCCYYNNN 0.0136183570291238 9361 23 20 0.869565217391304 0.00213652387565431
TF TF:M07379 Factor: c-Ets-2; motif: NNCTTCCTNNN 0.0142267867615767 3487 14 9 0.642857142857143 0.00258101519931173
TF TF:M07610 Factor: Nrf2; motif: NTGCTGAGTCANN 0.0142267867615767 1012 3 3 1 0.00296442687747036
TF TF:M11445 Factor: Elf-1; motif: NANCAGGAAGTR 0.0142267867615767 1689 20 8 0.4 0.00473653049141504
TF TF:M07461_1 Factor: KLF; motif: GGGNGGGG; match class: 1 0.0142267867615767 3397 23 12 0.521739130434783 0.0035325287017957
TF TF:M12315 Factor: ZF5; motif: RTGCGCGTGCACGYGN 0.0149278490829679 184 12 3 0.25 0.016304347826087
TF TF:M00444_1 Factor: VDR; motif: GGGKNARNRRGGWSA; match class: 1 0.0149278490829679 4534 14 10 0.714285714285714 0.00220555800617556
TF TF:M07261_1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 0.0149278490829679 4062 23 13 0.565217391304348 0.00320039389463319
TF TF:M09965_1 Factor: c-Jun; motif: NRTGAGTCAYN; match class: 1 0.0149278490829679 681 4 3 0.75 0.00440528634361234
TF TF:M09922_1 Factor: Fra-1; motif: NNNTGAGTCAYN; match class: 1 0.0149278490829679 677 4 3 0.75 0.00443131462333826
TF TF:M09972_1 Factor: BTEB2; motif: WGGGTGKGGCNGGN; match class: 1 0.0158435805782805 3919 21 12 0.571428571428571 0.00306200561367696
TF TF:M02104 Factor: NF-E2; motif: CATGACTCAGCANNCN 0.0158435805782805 1146 3 3 1 0.00261780104712042
TF TF:M09616_1 Factor: Fra-2; motif: RTGACTCANNN; match class: 1 0.0158435805782805 728 4 3 0.75 0.00412087912087912
TF TF:M07039_1 Factor: ETF; motif: CCCCGCCCCYN; match class: 1 0.0158435805782805 13611 23 23 1 0.00168980971273235
TF TF:M04685 Factor: NF-E2; motif: RTGACTCAG 0.0159125767981783 312 8 3 0.375 0.00961538461538462
TF TF:M00761_1 Factor: p53; motif: RGRCAWGNCY; match class: 1 0.0159125767981783 317 19 4 0.210526315789474 0.0126182965299685
TF TF:M00925_1 Factor: AP-1; motif: NTGACTCAN; match class: 1 0.0159125767981783 224 11 3 0.272727272727273 0.0133928571428571
TF TF:M10591 Factor: BSX; motif: NNCGTTAN 0.0159125767981783 7760 9 9 1 0.00115979381443299
TF TF:M08819_1 Factor: LKLF; motif: CNCCACCCS; match class: 1 0.0159125767981783 1532 23 8 0.347826086956522 0.00522193211488251
TF TF:M07103 Factor: JunB; motif: NRRTGASTCAK 0.0159125767981783 2383 4 4 1 0.00167855644146034
TF TF:M03815 Factor: c-Fos; motif: TGACTCAN 0.016653489734657 2455 4 4 1 0.00162932790224033
TF TF:M09971_1 Factor: GKLF; motif: WGGGYGKGGC; match class: 1 0.0168019546389544 1352 20 7 0.35 0.00517751479289941
TF TF:M00810 Factor: SRF; motif: SCCAWATAWGGMNMNNNN 0.0168688546848873 109 23 3 0.130434782608696 0.0275229357798165
TF TF:M04595_1 Factor: SALL2; motif: GGGTGGG; match class: 1 0.0168688546848873 7373 19 15 0.789473684210526 0.0020344500203445
TF TF:M08881 Factor: ETSLIKE; motif: NACTTCCTNN 0.0168688546848873 3140 16 9 0.5625 0.00286624203821656
TF TF:M10432 Factor: MAZ; motif: GGGMGGGGS 0.0168688546848873 9259 18 16 0.888888888888889 0.00172804838535479
TF TF:M00634 Factor: GCM; motif: CNNRCCCGCATD 0.0168688546848873 2152 7 5 0.714285714285714 0.00232342007434944
TF TF:M12173 Factor: GKLF; motif: NNCCMCRCCCN 0.0168688546848873 10023 20 18 0.9 0.00179586950014966
TF TF:M00925 Factor: AP-1; motif: NTGACTCAN 0.0169609022042459 2554 4 4 1 0.00156617071260767
TF TF:M00821 Factor: Nrf-2; motif: NTGCTGAGTCAKN 0.0169609022042459 4719 8 7 0.875 0.00148336511972876
TF TF:M12119 Factor: FPM315; motif: NGTGCTCCCN 0.0169609022042459 1239 16 6 0.375 0.00484261501210654
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.0169609022042459 12302 23 22 0.956521739130435 0.00178832710128434
TF TF:M01253 Factor: CNOT3; motif: GGCCGCGSSS 0.0177918751654974 3926 9 7 0.777777777777778 0.00178298522669384
TF TF:M09964_1 Factor: JunD; motif: NRTGAGTCAYN; match class: 1 0.0181418623748088 854 4 3 0.75 0.00351288056206089
TF TF:M00001 Factor: MyoD; motif: SRACAGGTGKYG 0.0187365783370212 1365 3 3 1 0.0021978021978022
TF TF:M09617 Factor: c-Fos; motif: RTGAGTCAYNN 0.0187365783370212 2663 4 4 1 0.00150206533984228
TF TF:M04693 Factor: c-Fos; motif: RTGASTCAY 0.0189259793481615 2678 4 4 1 0.00149365197908887
TF TF:M03870_1 Factor: Fra-2; motif: TGASTCANCN; match class: 1 0.0200542098152278 902 4 3 0.75 0.00332594235033259
TF TF:M00470_1 Factor: AP-2gamma; motif: GCCYNNGGS; match class: 1 0.0200542098152278 5600 11 9 0.818181818181818 0.00160714285714286
TF TF:M11374 Factor: Spi-B; motif: NAWGRGGAAGTR 0.0200640655340489 2512 20 9 0.45 0.0035828025477707
TF TF:M03876 Factor: Kaiso; motif: GCMGGGRGCRGS 0.0200640655340489 13622 21 21 1 0.00154162384378212
TF TF:M00800_1 Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1 0.0200640655340489 4268 11 8 0.727272727272727 0.00187441424554827
TF TF:M00800 Factor: AP-2; motif: GSCCSCRGGCNRNRNN 0.0200640655340489 9119 20 17 0.85 0.00186423949994517
TF TF:M07461 Factor: KLF; motif: GGGNGGGG 0.0200640655340489 8757 19 16 0.842105263157895 0.00182710974077881
TF TF:M08944_1 Factor: JUNB:C-JUN; motif: NATGACKCAT; match class: 1 0.0200640655340489 933 4 3 0.75 0.00321543408360129
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.0200640655340489 14096 23 23 1 0.0016316685584563
TF TF:M00733_1 Factor: SMAD4; motif: GKSRKKCAGMCANCY; match class: 1 0.0200640655340489 2823 4 4 1 0.00141693234148069
TF TF:M00924 Factor: AP-1; motif: TGACTCANNSKN 0.0200640655340489 2801 4 4 1 0.00142806140664049
TF TF:M09973_1 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN; match class: 1 0.0200640655340489 6607 21 15 0.714285714285714 0.00227031935825639
TF TF:M00655 Factor: PEA3; motif: ACWTCCK 0.0200640655340489 9452 21 18 0.857142857142857 0.0019043588658485
TF TF:M07600_1 Factor: C-Fos; motif: NNTGACTCAN; match class: 1 0.0200640655340489 279 11 3 0.272727272727273 0.010752688172043
TF TF:M10014 Factor: FXR; motif: NRGGKCANTGRCCNNNNGG 0.0200640655340489 5652 11 9 0.818181818181818 0.00159235668789809
TF TF:M00971 Factor: Ets; motif: ACTTCCTS 0.0200640655340489 2349 7 5 0.714285714285714 0.00212856534695615
TF TF:M04617 Factor: LRF; motif: NGNAGNGGGTYN 0.0200640655340489 6164 16 12 0.75 0.00194678780012979
TF TF:M08875 Factor: E2F; motif: NNTTTCGCGCN 0.020094278041479 6203 20 14 0.7 0.00225697243269386
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.020094278041479 14106 23 23 1 0.00163051183893379
TF TF:M07292 Factor: GLI; motif: NTGGGTGGTN 0.0201127584357162 5763 11 9 0.818181818181818 0.00156168662155128
TF TF:M07409 Factor: BTEB2; motif: GCCCCRCCCH 0.0204130533545371 5198 23 14 0.608695652173913 0.00269334359368988
TF TF:M00428 Factor: E2F-1; motif: NKTSSCGC 0.0204130533545371 8947 22 18 0.818181818181818 0.00201184754666369
TF TF:M07048_1 Factor: MafG; motif: CMATGACTCAGCAGA; match class: 1 0.0204130533545371 1550 3 3 1 0.00193548387096774
TF TF:M09916 Factor: Erm; motif: NRRSAGGAARNGRN 0.0204130533545371 6711 21 15 0.714285714285714 0.00223513634331694
TF TF:M03835 Factor: Nrf2; motif: ACNRTGACTCAGCANWA 0.0204130533545371 1562 3 3 1 0.00192061459667093
TF TF:M02075 Factor: PDEF; motif: MCCGGATNTN 0.0204130533545371 2666 16 8 0.5 0.00300075018754689
TF TF:M00931 Factor: Sp1; motif: GGGGCGGGGC 0.0204130533545371 10281 23 20 0.869565217391304 0.00194533605680381
TF TF:M08923 Factor: JUNB:FRA-2; motif: NRTGASTCAT 0.0204130533545371 2927 4 4 1 0.00136658694909464
TF TF:M00444 Factor: VDR; motif: GGGKNARNRRGGWSA 0.0204130533545371 10308 23 20 0.869565217391304 0.00194024058983314
TF TF:M10074 Factor: Spi-B; motif: NRAAAGAGGAAGTGARA 0.0211923393549357 1611 3 3 1 0.00186219739292365
TF TF:M00431 Factor: E2F-1; motif: TTTSGCGS 0.0217262062387774 7257 20 15 0.75 0.0020669698222406
TF TF:M12135_1 Factor: mbnl2; motif: NYGCYTYGCTTN; match class: 1 0.0217262062387774 1097 20 6 0.3 0.00546946216955333
TF TF:M09915_1 Factor: PEA3; motif: NNCAGGAARNN; match class: 1 0.0217262062387774 5690 6 6 1 0.00105448154657294
TF TF:M07102_1 Factor: c-Jun; motif: NNNNRRTGASTCAN; match class: 1 0.0217262062387774 3047 4 4 1 0.00131276665572694
TF TF:M01172 Factor: PU.1; motif: NNNNYYYACTTCCTCTTTY 0.0220171283301789 4281 7 6 0.857142857142857 0.00140154169586545
TF TF:M08874 Factor: E2F1; motif: NNNNNGCGSSAAAN 0.0220551690148211 7201 22 16 0.727272727272727 0.0022219136231079
TF TF:M09729 Factor: LUMAN; motif: CYCAGCYYCY 0.0224563937342153 10686 12 12 1 0.00112296462661426
TF TF:M07415_1 Factor: Elf-1; motif: AWCCCGGAAGTN; match class: 1 0.0224563937342153 2397 22 9 0.409090909090909 0.00375469336670839
TF TF:M00932 Factor: Sp1; motif: NNGGGGCGGGGNN 0.0224563937342153 10419 23 20 0.869565217391304 0.00191957001631635
TF TF:M00938 Factor: E2F-1; motif: TTGGCGCGRAANNGNM 0.0224563937342153 7334 13 11 0.846153846153846 0.0014998636487592
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.0224563937342153 8492 23 18 0.782608695652174 0.00211964201601507
TF TF:M07290_1 Factor: GLI; motif: NGACCMCCCAN; match class: 1 0.0224563937342153 1902 17 7 0.411764705882353 0.00368033648790747
TF TF:M08208 Factor: E2F-3:FOXI1; motif: NGACACCGCGCCCAC 0.0225304106854936 12560 22 21 0.954545454545455 0.00167197452229299
TF TF:M08920 Factor: JUNB:FOSB; motif: NRTGASTCAT 0.0225304106854936 3151 4 4 1 0.00126943827356395
TF TF:M07092 Factor: Fra-2; motif: NRRTGASTCAB 0.0225304106854936 3156 4 4 1 0.00126742712294043
TF TF:M11272 Factor: JunB; motif: NATGASTCAYN 0.0238561084968905 799 11 4 0.363636363636364 0.00500625782227785
TF TF:M01858 Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN 0.0239512869283708 7418 13 11 0.846153846153846 0.00148287948234025
TF TF:M00517_1 Factor: AP-1; motif: NNNTGAGTCAKCN; match class: 1 0.0239512869283708 3227 4 4 1 0.00123954136969321
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0240567303244535 7696 23 17 0.739130434782609 0.00220893970893971
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0240567303244535 7696 23 17 0.739130434782609 0.00220893970893971
TF TF:M08936 Factor: C-JUN:FOSB; motif: NATGACTCAY 0.0247355015199809 3271 4 4 1 0.00122286762457964
TF TF:M11387 Factor: elf5; motif: NNNNMGGAAGTN 0.0250520033174676 2598 21 9 0.428571428571429 0.00346420323325635
TF TF:M08942 Factor: C-FOS:C-JUN; motif: ATGAGTCAYN 0.0250520033174676 3289 4 4 1 0.00121617512921861
TF TF:M12158 Factor: KLF15; motif: NCCMCGCCCMCN 0.0254544706631215 11088 21 19 0.904761904761905 0.00171356421356421
TF TF:M12136 Factor: mbnl2; motif: NYGCYTYGCYTN 0.0254544706631215 5391 10 8 0.8 0.00148395473938045
TF TF:M09903 Factor: elf5; motif: NNNANSAGGAAGTNN 0.0255808490096966 1243 19 6 0.315789473684211 0.00482703137570394
TF TF:M07407_1 Factor: THAP1; motif: YTGCCCNNA; match class: 1 0.0255808490096966 4197 17 10 0.588235294117647 0.00238265427686443
TF TF:M00448 Factor: Zic1; motif: KGGGTGGTC 0.0260690447726861 10948 12 12 1 0.00109609061015711
TF TF:M00221 Factor: SREBP-1; motif: KATCACCCCAC 0.0263674104540677 7502 20 15 0.75 0.00199946680885097
TF TF:M00986_1 Factor: Churchill; motif: CGGGNN; match class: 1 0.0278493289343372 10357 15 14 0.933333333333333 0.00135174278265907
TF TF:M07618 Factor: SRF; motif: CCTTWTATGGNN 0.0278970476784496 167 23 3 0.130434782608696 0.0179640718562874
TF TF:M08441_1 Factor: AP-2gamma:Elk-1; motif: NGCCKNRGGSGRCGGAAGTG; match class: 1 0.0279640640042224 12761 16 16 1 0.00125382023352402
TF TF:M03869 Factor: Fra-1; motif: TGACTCAN 0.0280897227634752 3514 4 4 1 0.00113830392714855
TF TF:M06948_1 Factor: Sp2; motif: TGGGCGCGCCCA; match class: 1 0.0280897227634752 6205 19 13 0.684210526315789 0.00209508460918614
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.0280897227634752 9715 23 19 0.826086956521739 0.00195573854863613
TF TF:M07247 Factor: CLOCK; motif: CCACSTGW 0.0280897227634752 1953 3 3 1 0.00153609831029186
TF TF:M08925 Factor: JUNB:C-FOS; motif: NATGAGTCATNN 0.0280897227634752 3490 4 4 1 0.00114613180515759
TF TF:M08214 Factor: Elk-1:ETV7; motif: ANSCGGACGGATDTCCGGNT 0.0280897227634752 7951 16 13 0.8125 0.00163501446358949
TF TF:M09982 Factor: c-MAF; motif: NNAWNTGCTGASNNNGCNN 0.0280897227634752 1959 3 3 1 0.00153139356814701
TF TF:M00470 Factor: AP-2gamma; motif: GCCYNNGGS 0.0280897227634752 9422 13 12 0.923076923076923 0.00127361494374867
TF TF:M00186 Factor: SRF; motif: GNCCAWATAWGGMN 0.0280897227634752 172 23 3 0.130434782608696 0.0174418604651163
TF TF:M09762_1 Factor: NF1B; motif: CYTGGCNYNCWGCCAN; match class: 1 0.0280897227634752 1514 7 4 0.571428571428571 0.00264200792602378
TF TF:M09967 Factor: AP-2rep; motif: NGGGGCGGGGC 0.0280897227634752 4023 10 7 0.7 0.00173999502858563
TF TF:M08190_1 Factor: AR; motif: GGAACGGWACATGTTCT; match class: 1 0.0283884197979795 2001 3 3 1 0.00149925037481259
TF TF:M09726_1 Factor: GATAD2A; motif: CCTKTG; match class: 1 0.0293604398187515 9052 21 17 0.80952380952381 0.00187803800265135
TF TF:M11005 Factor: LHX4; motif: NNCRTTAN 0.0293604398187515 10614 11 11 1 0.00103636706237045
TF TF:M08933_1 Factor: JUND:C-FOS; motif: NNATGAGTCATNN; match class: 1 0.0295020433011623 1312 4 3 0.75 0.00228658536585366
TF TF:M03870 Factor: Fra-2; motif: TGASTCANCN 0.0296244878663961 3634 4 4 1 0.00110071546505228
TF TF:M09918_1 Factor: Pet-1; motif: GCNGGAAGYG; match class: 1 0.0296244878663961 7159 21 15 0.714285714285714 0.00209526470177399
TF TF:M01652 Factor: p53; motif: RGRCWWGYCYNGRCWWGYYY 0.0296244878663961 8083 21 16 0.761904761904762 0.00197946307064209
TF TF:M08940 Factor: C-JUN:FRA-2; motif: NNRTGAGTCAYN 0.0296244878663961 3631 4 4 1 0.00110162489672267
TF TF:M07409_1 Factor: BTEB2; motif: GCCCCRCCCH; match class: 1 0.0296244878663961 1829 10 5 0.5 0.00273373428102788
TF TF:M03834 Factor: N-Myc; motif: GSSCACGYGS 0.0300416467123994 1414 18 6 0.333333333333333 0.00424328147100424
TF TF:M01242_1 Factor: MTF-1; motif: GTGTGCANMACTTTGCGCAC; match class: 1 0.0300676062060262 701 14 4 0.285714285714286 0.00570613409415121
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.0300676062060262 4149 10 7 0.7 0.00168715353097132
TF TF:M01073 Factor: HIC1; motif: NNNGGKTGCCCSNNNNNN 0.0301693019529134 4088 18 10 0.555555555555556 0.00244618395303327
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.0301693019529134 10853 23 20 0.869565217391304 0.00184280844006266
TF TF:M07615_1 Factor: Sp3; motif: GGGGCGGGGSNN; match class: 1 0.0301693019529134 2885 10 6 0.6 0.00207972270363951
TF TF:M10880 Factor: Alx-4; motif: NNCRTTAN 0.0301693019529134 8535 8 8 1 0.000937316930287053
TF TF:M07208_1 Factor: EGR1; motif: NCNCCGCCCCCGCN; match class: 1 0.0301693019529134 2194 21 8 0.380952380952381 0.00364630811303555
TF TF:M09595 Factor: BCL-11A; motif: NAAAGAGGAAGTGARAN 0.0301693019529134 3696 4 4 1 0.00108225108225108
TF TF:M00749 Factor: SREBP-1; motif: CACSCCA 0.0301825439285281 8584 17 14 0.823529411764706 0.0016309412861137
TF TF:M08938 Factor: C-JUN:FRA-1; motif: NNATGACTCATNN 0.0301843941085379 3714 4 4 1 0.00107700592353258
TF TF:M03797 Factor: Msx-2; motif: TWWTTGGDGABN 0.0303160409127767 4889 9 7 0.777777777777778 0.00143178564123543
TF TF:M07206 Factor: E2F-1; motif: NGGGCGGGARV 0.0303796222299111 14575 22 22 1 0.00150943396226415
TF TF:M11265 Factor: c-Jun; motif: NATGACTCATN 0.0308263871783511 4632 19 11 0.578947368421053 0.00237478411053541
TF TF:M01165_1 Factor: Elk-1; motif: RACCGGAAGTR; match class: 1 0.0316311884472912 2185 3 3 1 0.00137299771167048
TF TF:M09606_1 Factor: nerf; motif: NRRNSCGGAAGNRNNNN; match class: 1 0.032307949739906 1704 21 7 0.333333333333333 0.00410798122065728
TF TF:M01242 Factor: MTF-1; motif: GTGTGCANMACTTTGCGCAC 0.0324105328852487 3931 16 9 0.5625 0.00228949376748919
TF TF:M12026_1 Factor: TBX2; motif: NNNGTGTSNN; match class: 1 0.0324105328852487 1911 10 5 0.5 0.00261643118785976
TF TF:M09605_1 Factor: Elf-1; motif: NAANCMGGAAGTGN; match class: 1 0.0324105328852487 1306 20 6 0.3 0.00459418070444104
TF TF:M00341 Factor: GABP; motif: VCCGGAAGNGCR 0.0324105328852487 8224 21 16 0.761904761904762 0.00194552529182879
TF TF:M12215 Factor: GLIS1; motif: NACCCCCCACGNNGN 0.0324105328852487 596 17 4 0.235294117647059 0.00671140939597315
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0324105328852487 10233 14 13 0.928571428571429 0.00127039968728623
TF TF:M00448_1 Factor: Zic1; motif: KGGGTGGTC; match class: 1 0.0333028616605807 4300 10 7 0.7 0.00162790697674419
TF TF:M12186 Factor: BTEB4; motif: NCCACGCCCM 0.0336018939615288 9135 15 13 0.866666666666667 0.00142309797482211
TF TF:M10438_1 Factor: ZF5; motif: GGSGCGCGS; match class: 1 0.0336018939615288 14873 23 23 1 0.00154642641027365
TF TF:M10002_1 Factor: NF-1C; motif: NYTGGCNNYNNGCCARN; match class: 1 0.0336018939615288 1693 7 4 0.571428571428571 0.00236266981689309
TF TF:M00032 Factor: c-Ets-1(p54); motif: NCMGGAWGYN 0.0336018939615288 7858 20 15 0.75 0.00190888266734538
TF TF:M09907_1 Factor: Erg; motif: NRRSAGGAAGNGG; match class: 1 0.0341488721431503 5070 7 6 0.857142857142857 0.00118343195266272
TF TF:M08914 Factor: FRA-2; motif: RTGANTCA 0.034182443944959 3934 4 4 1 0.00101677681748856
TF TF:M11446 Factor: Elf-1; motif: RANSMGGAAGTR 0.0382576415532173 2915 21 9 0.428571428571429 0.00308747855917667
TF TF:M09901_1 Factor: nerf; motif: NNNCCGGAAGTGN; match class: 1 0.0382576415532173 1363 20 6 0.3 0.00440205429200293
TF TF:M11987 Factor: NFATc3; motif: NAYGGAAANW 0.0384339506294712 2409 3 3 1 0.0012453300124533
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.03846614635819 7283 14 11 0.785714285714286 0.00151036660716738
TF TF:M10073 Factor: PU.1; motif: NRAAAGAGGAAGTGRNN 0.03846614635819 2416 3 3 1 0.00124172185430464
TF TF:M01783 Factor: SP2; motif: GGGCGGGAC 0.0388122144499279 9148 23 18 0.782608695652174 0.00196764320069961
TF TF:M09615 Factor: Fra-1; motif: NRTGACTCATN 0.0389032873872319 4111 4 4 1 0.000972999270250547
TF TF:M08922 Factor: JUNB:FRA-1; motif: NNRTGACTCATNN 0.0402713467251317 1834 11 5 0.454545454545455 0.00272628135223555
TF TF:M11415_1 Factor: GABP-alpha; motif: NRCCGGAAGTN; match class: 1 0.0402713467251317 546 20 4 0.2 0.00732600732600733
TF TF:M09603_1 Factor: Egr-1; motif: NNNNNGYGKGGGNGGGNN; match class: 1 0.0403247633417226 1317 21 6 0.285714285714286 0.00455580865603645
TF TF:M03558 Factor: P73; motif: GNNNRRRCNTGCMNNTSASN 0.0403267345633951 4679 17 10 0.588235294117647 0.00213720880530028
TF TF:M11988_1 Factor: NFATc3; motif: NTTTCCRYGGAAAN; match class: 1 0.0403267345633951 6648 21 14 0.666666666666667 0.00210589651022864
TF TF:M09995 Factor: MZF-1; motif: NRNRGGGAWTNRN 0.0403267345633951 1662 12 5 0.416666666666667 0.00300842358604091
TF TF:M09893 Factor: E2F-3; motif: NNGGCGGGAAA 0.0403267345633951 6065 14 10 0.714285714285714 0.00164880461665293
TF TF:M01304 Factor: SRF; motif: NNCCAWAWAAGGV 0.0403267345633951 218 23 3 0.130434782608696 0.0137614678899083
TF TF:M08934 Factor: JUND; motif: NATGAGTCAT 0.0403267345633951 4329 8 6 0.75 0.00138600138600139
TF TF:M01595 Factor: STAT3; motif: NNTTCCRGGAANNNNN 0.0403267345633951 7736 17 13 0.764705882352941 0.00168045501551189
TF TF:M11655 Factor: HSF1; motif: NGAANGTTCKRGAAN 0.0406272989756526 1207 16 5 0.3125 0.00414250207125104
TF TF:M11880 Factor: pax-6; motif: NYACGCWTSANYGMNCN 0.0406272989756526 13087 21 20 0.952380952380952 0.00152823412546802
TF TF:M00378_1 Factor: Pax-4; motif: NNNNNYCACCCB; match class: 1 0.0406272989756526 14711 21 21 1 0.00142750322887635
TF TF:M09659 Factor: PU.1; motif: NRAAAGAGGAAGTGARA 0.0406272989756526 2523 3 3 1 0.00118906064209275
TF TF:M03551 Factor: JunB; motif: TGACTCAN 0.0409378137011757 4253 4 4 1 0.000940512579355749
TF TF:M00199_1 Factor: AP-1; motif: NTGASTCAG; match class: 1 0.0409378137011757 4265 4 4 1 0.000937866354044549
TF TF:M02280 Factor: AP1; motif: TGACTCA 0.0409378137011757 4255 4 4 1 0.000940070505287897
TF TF:M09785 Factor: SIX1; motif: GWAACCTGANM 0.0413324940648142 311 17 3 0.176470588235294 0.00964630225080386
TF TF:M09760 Factor: DPF2; motif: NYCACYTCCYCNYYCY 0.0413413090919261 8179 10 9 0.9 0.00110037901944003
TF TF:M02069_1 Factor: Erm; motif: ACCGGAAGTN; match class: 1 0.0413413090919261 1955 20 7 0.35 0.00358056265984655
TF TF:M09923 Factor: Fra-2; motif: NNRTGAGTCAYN 0.0423478304577468 4336 4 4 1 0.000922509225092251
TF TF:M09999 Factor: Nrf2; motif: WWNTGCTGAGTCAT 0.042993312437336 2658 3 3 1 0.00112866817155756
TF TF:M12217 Factor: GLIS2; motif: ACCCCCCRCGWNGC 0.042993312437336 567 10 3 0.3 0.00529100529100529
TF TF:M00174 Factor: AP-1; motif: NNTGACTCANN 0.042993312437336 1921 11 5 0.454545454545455 0.00260281103591879
TF TF:M11530 Factor: E2F-2; motif: NWTTTGGCGCCAWWNN 0.042993312437336 14593 20 20 1 0.00137052011238265
TF TF:M08526_1 Factor: E2F-3:HES-7; motif: NNNSGCGCSNNNNNCRCGYGNN; match class: 1 0.042993312437336 14997 22 22 1 0.0014669600586784
TF TF:M07090 Factor: c-Fos; motif: NNTGASTCATN 0.042993312437336 4378 4 4 1 0.000913659205116492
TF TF:M00037_1 Factor: NF-E2; motif: TGCTGAGTCAY; match class: 1 0.042993312437336 1710 4 3 0.75 0.00175438596491228
TF TF:M10530 Factor: sp4; motif: NNNGCYCCGCCCCCY 0.042993312437336 8227 10 9 0.9 0.00109395891576516
TF TF:M01273 Factor: SP4; motif: SCCCCGCCCCS 0.0432015499889194 3296 10 6 0.6 0.00182038834951456
TF TF:M01306_1 Factor: ZABC1; motif: ATTCCNAC; match class: 1 0.0438824905208478 2690 3 3 1 0.00111524163568773
TF TF:M12151 Factor: Sp1; motif: NWRGCCMCGCCCMCN 0.0438824905208478 6821 15 11 0.733333333333333 0.00161266676440405
TF TF:M11447_1 Factor: Elf-1; motif: NAMCCGGAAGTN; match class: 1 0.0440872985109752 2593 20 8 0.4 0.00308522946394138
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0441918400981871 6807 23 15 0.652173913043478 0.00220361392684002
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0441918400981871 9362 23 18 0.782608695652174 0.00192266609698782
TF TF:M08941_1 Factor: C-JUN:FRA-2; motif: NRTGACGTMAT; match class: 1 0.0442838399699222 3353 23 10 0.434782608695652 0.00298240381747689
TF TF:M12313_1 Factor: ZNF460; motif: NNACNCCCCCCNN; match class: 1 0.0442838399699222 2203 14 6 0.428571428571429 0.00272355878347708
TF TF:M00339 Factor: c-Ets-1; motif: RCAGGAAGTGNNTNS 0.0442838399699222 6806 21 14 0.666666666666667 0.00205700852189245
TF TF:M08283 Factor: Fli-1:ETV7; motif: NSMGGAMGGATNTCCGNN 0.0442838399699222 2910 8 5 0.625 0.00171821305841924
TF TF:M12152 Factor: Sp1; motif: NWRGCCACGCCCMCN 0.0442838399699222 7341 6 6 1 0.00081732733959951
TF TF:M05327_1 Factor: WT1; motif: NGCGGGGGGGTSMMCYN; match class: 1 0.0442838399699222 1757 4 3 0.75 0.00170745589072282
TF TF:M09729_1 Factor: LUMAN; motif: CYCAGCYYCY; match class: 1 0.0444017965217035 4645 15 9 0.6 0.00193756727664155
TF TF:M01259 Factor: CTCF; motif: NNNNNNCCASNAGRKGGCRS 0.0444017965217035 1968 7 4 0.571428571428571 0.00203252032520325
TF TF:M02078 Factor: SPI1; motif: NGRGGAAGTN 0.0444017965217035 3506 7 5 0.714285714285714 0.00142612664004564
TF TF:M09965 Factor: c-Jun; motif: NRTGAGTCAYN 0.0444017965217035 4492 4 4 1 0.000890471950133571
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.0446205408342268 15260 23 23 1 0.00150720838794233
TF TF:M01721_1 Factor: PUR1; motif: GGGNCAGNN; match class: 1 0.0446620753364006 3414 16 8 0.5 0.00234329232571763
TF TF:M04109_1 Factor: RUNX3; motif: NRACCGCAAACCGCAN; match class: 1 0.0447227570601944 3878 9 6 0.666666666666667 0.00154718927282104
TF TF:M11390 Factor: Erg; motif: NACAGGAARTN 0.0447227570601944 2772 3 3 1 0.00108225108225108
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0447227570601944 7728 21 15 0.714285714285714 0.00194099378881988
TF TF:M08525_1 Factor: E2F-1:HES-7; motif: GGCRCGTGSYNNWNGGCGCSM; match class: 1 0.0447227570601944 15268 23 23 1 0.00150641865339272
TF TF:M09922 Factor: Fra-1; motif: NNNTGAGTCAYN 0.0456187470336191 4573 4 4 1 0.000874699322108025
TF TF:M11595 Factor: GCMa; motif: RTGCGGGTN 0.0456187470336191 12117 12 12 1 0.000990344144590245
TF TF:M00736 Factor: E2F-1:DP-1; motif: TTTCSCGC 0.0456187470336191 10390 23 19 0.826086956521739 0.00182868142444658
TF TF:M08826_1 Factor: NF-E4; motif: GTGAGGS; match class: 1 0.0459065803657386 4695 15 9 0.6 0.00191693290734824
TF TF:M11264 Factor: c-Jun; motif: NATGASTCATN 0.0463817110084306 4600 4 4 1 0.000869565217391304
TF TF:M12153 Factor: Sp3; motif: NGCCACGCCCMCN 0.047975833722968 6205 5 5 1 0.0008058017727639
TF TF:M01863 Factor: ATF-3; motif: RTKRCGTCANN 0.049927351454536 1885 4 3 0.75 0.00159151193633952
WP WP:WP2272 Pathogenic Escherichia coli infection 0.000221667642565097 55 18 4 0.222222222222222 0.0727272727272727
WP WP:WP98 Prostaglandin Synthesis and Regulation 0.000221667642565097 45 7 3 0.428571428571429 0.0666666666666667
WP WP:WP3680 Association Between Physico-Chemical Features and Toxicity Associated Pathways 0.000497549106489442 68 21 4 0.19047619047619 0.0588235294117647
WP WP:WP51 Regulation of Actin Cytoskeleton 0.000497549106489442 149 19 5 0.263157894736842 0.0335570469798658
WP WP:WP306 Focal Adhesion 0.00176001343937963 201 20 5 0.25 0.0248756218905473
WP WP:WP3888 VEGFA-VEGFR2 Signaling Pathway 0.00530311265942559 437 19 6 0.315789473684211 0.0137299771167048
WP WP:WP4217 Ebola Virus Pathway on Host 0.0161384170294159 130 18 3 0.166666666666667 0.0230769230769231

pEpi36 transcription factor target enrichment of top program genes

TF enrichment of pEpi36
Possible regulators of activation of pEpi36 in epithelial cells. (Left) pearson correlation of TF expression and gene expression program activatity in Epithelial cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.