pS19 program activity among Stromal cells

Activation of pS19
pS19 gene program activation in Stromal cells.
Gene program activation of pS19 by different cell subtypes
pS19 gene program activation among cells of different subtypes (Stromal cells).

pS19 top program genes

Top genes of pS19 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS19 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS19
pS19 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0002399 MHC class II protein complex assembly 0.000398730782352319 4 94 3 0.0319148936170213 0.75
GO:BP GO:0019882 antigen processing and presentation 0.000398730782352319 234 65 9 0.138461538461538 0.0384615384615385
GO:BP GO:0002503 peptide antigen assembly with MHC class II protein complex 0.000398730782352319 4 94 3 0.0319148936170213 0.75
GO:BP GO:0002501 peptide antigen assembly with MHC protein complex 0.00155631732522893 6 94 3 0.0319148936170213 0.5
GO:BP GO:0044281 small molecule metabolic process 0.00169581244314797 1921 9 7 0.777777777777778 0.00364393545028631
GO:BP GO:0002396 MHC protein complex assembly 0.00169581244314797 7 94 3 0.0319148936170213 0.428571428571429
GO:BP GO:0070661 leukocyte proliferation 0.00177898812592387 325 94 10 0.106382978723404 0.0307692307692308
GO:BP GO:0046503 glycerolipid catabolic process 0.00177898812592387 74 11 3 0.272727272727273 0.0405405405405405
GO:BP GO:0032879 regulation of localization 0.00177898812592387 2872 58 23 0.396551724137931 0.008008356545961
GO:BP GO:0032943 mononuclear cell proliferation 0.00177898812592387 297 47 7 0.148936170212766 0.0235690235690236
GO:BP GO:0006631 fatty acid metabolic process 0.00177898812592387 404 7 4 0.571428571428571 0.0099009900990099
GO:BP GO:0006690 icosanoid metabolic process 0.00177898812592387 124 7 3 0.428571428571429 0.0241935483870968
GO:BP GO:0033559 unsaturated fatty acid metabolic process 0.00177898812592387 116 7 3 0.428571428571429 0.0258620689655172
GO:BP GO:0048002 antigen processing and presentation of peptide antigen 0.00177898812592387 192 65 7 0.107692307692308 0.0364583333333333
GO:BP GO:0046596 regulation of viral entry into host cell 0.00208671579603677 43 21 3 0.142857142857143 0.0697674418604651
GO:BP GO:2000147 positive regulation of cell motility 0.00208671579603677 591 36 8 0.222222222222222 0.0135363790186125
GO:BP GO:0045582 positive regulation of T cell differentiation 0.00208671579603677 91 30 4 0.133333333333333 0.043956043956044
GO:BP GO:0001775 cell activation 0.00211908953135116 1495 21 9 0.428571428571429 0.00602006688963211
GO:BP GO:0051272 positive regulation of cellular component movement 0.00211908953135116 604 36 8 0.222222222222222 0.0132450331125828
GO:BP GO:0010885 regulation of cholesterol storage 0.00211908953135116 18 53 3 0.0566037735849057 0.166666666666667
GO:BP GO:0040017 positive regulation of locomotion 0.00211908953135116 606 36 8 0.222222222222222 0.0132013201320132
GO:BP GO:0045621 positive regulation of lymphocyte differentiation 0.00229355086585164 104 30 4 0.133333333333333 0.0384615384615385
GO:BP GO:0045657 positive regulation of monocyte differentiation 0.00229355086585164 11 99 3 0.0303030303030303 0.272727272727273
GO:BP GO:0010878 cholesterol storage 0.00229355086585164 20 53 3 0.0566037735849057 0.15
GO:BP GO:0035710 CD4-positive, alpha-beta T cell activation 0.00229355086585164 104 30 4 0.133333333333333 0.0384615384615385
GO:BP GO:0052372 modulation by symbiont of entry into host 0.00229355086585164 50 21 3 0.142857142857143 0.06
GO:BP GO:0006633 fatty acid biosynthetic process 0.00236453063276445 170 7 3 0.428571428571429 0.0176470588235294
GO:BP GO:0002478 antigen processing and presentation of exogenous peptide antigen 0.00265827767595344 174 94 7 0.074468085106383 0.0402298850574713
GO:BP GO:0050670 regulation of lymphocyte proliferation 0.00265827767595344 230 30 5 0.166666666666667 0.0217391304347826
GO:BP GO:0032944 regulation of mononuclear cell proliferation 0.00269949406029627 232 30 5 0.166666666666667 0.021551724137931
GO:BP GO:0045321 leukocyte activation 0.00298127313776869 1332 43 12 0.27906976744186 0.00900900900900901
GO:BP GO:0019884 antigen processing and presentation of exogenous antigen 0.00298233746552724 182 94 7 0.074468085106383 0.0384615384615385
GO:BP GO:0070663 regulation of leukocyte proliferation 0.00340386197770103 251 30 5 0.166666666666667 0.0199203187250996
GO:BP GO:0072330 monocarboxylic acid biosynthetic process 0.00345332354249439 226 7 3 0.428571428571429 0.0132743362831858
GO:BP GO:0050730 regulation of peptidyl-tyrosine phosphorylation 0.00345332354249439 269 47 6 0.127659574468085 0.0223048327137546
GO:BP GO:0046651 lymphocyte proliferation 0.00345332354249439 294 43 6 0.13953488372093 0.0204081632653061
GO:BP GO:0030217 T cell differentiation 0.00345332354249439 260 30 5 0.166666666666667 0.0192307692307692
GO:BP GO:0032787 monocarboxylic acid metabolic process 0.00345332354249439 658 7 4 0.571428571428571 0.0060790273556231
GO:BP GO:0046718 viral entry into host cell 0.00345332354249439 141 53 5 0.0943396226415094 0.0354609929078014
GO:BP GO:0002573 myeloid leukocyte differentiation 0.00345332354249439 213 19 4 0.210526315789474 0.0187793427230047
GO:BP GO:1903792 negative regulation of anion transport 0.00370371168569686 235 7 3 0.428571428571429 0.0127659574468085
GO:BP GO:0060425 lung morphogenesis 0.00396081111702452 50 83 4 0.0481927710843374 0.08
GO:BP GO:0009743 response to carbohydrate 0.00404026484180134 243 18 4 0.222222222222222 0.0164609053497942
GO:BP GO:0044409 entry into host 0.0040954489652598 154 53 5 0.0943396226415094 0.0324675324675325
GO:BP GO:0048522 positive regulation of cellular process 0.00458320768021696 5757 24 17 0.708333333333333 0.00295292687163453
GO:BP GO:0045580 regulation of T cell differentiation 0.00458764065321229 152 30 4 0.133333333333333 0.0263157894736842
GO:BP GO:0030335 positive regulation of cell migration 0.00458764065321229 567 36 7 0.194444444444444 0.0123456790123457
GO:BP GO:0046631 alpha-beta T cell activation 0.00482150080791718 155 30 4 0.133333333333333 0.0258064516129032
GO:BP GO:0006641 triglyceride metabolic process 0.00482150080791718 113 77 5 0.0649350649350649 0.0442477876106195
GO:BP GO:0002263 cell activation involved in immune response 0.00483841362173211 721 21 6 0.285714285714286 0.00832177531206657
GO:BP GO:1903708 positive regulation of hemopoiesis 0.00483841362173211 157 30 4 0.133333333333333 0.0254777070063694
GO:BP GO:1902107 positive regulation of leukocyte differentiation 0.00483841362173211 157 30 4 0.133333333333333 0.0254777070063694
GO:BP GO:0002366 leukocyte activation involved in immune response 0.00483841362173211 717 21 6 0.285714285714286 0.00836820083682008
GO:BP GO:0042110 T cell activation 0.00484673702826927 489 30 6 0.2 0.0122699386503067
GO:BP GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 0.0053450778925282 198 47 5 0.106382978723404 0.0252525252525253
GO:BP GO:0008283 cell population proliferation 0.0053450778925282 2054 24 10 0.416666666666667 0.00486854917234664
GO:BP GO:0052126 movement in host environment 0.00539784122750548 177 53 5 0.0943396226415094 0.0282485875706215
GO:BP GO:2000514 regulation of CD4-positive, alpha-beta T cell activation 0.00561224670708769 67 30 3 0.1 0.0447761194029851
GO:BP GO:0010817 regulation of hormone levels 0.00561224670708769 536 100 11 0.11 0.0205223880597015
GO:BP GO:0046649 lymphocyte activation 0.00561224670708769 771 21 6 0.285714285714286 0.00778210116731518
GO:BP GO:0010634 positive regulation of epithelial cell migration 0.00561224670708769 181 53 5 0.0943396226415094 0.0276243093922652
GO:BP GO:0051179 localization 0.005792894125012 6901 22 17 0.772727272727273 0.0024634110998406
GO:BP GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 0.005792894125012 103 94 5 0.0531914893617021 0.0485436893203883
GO:BP GO:0016053 organic acid biosynthetic process 0.005792894125012 338 7 3 0.428571428571429 0.00887573964497041
GO:BP GO:0046632 alpha-beta T cell differentiation 0.005792894125012 113 19 3 0.157894736842105 0.0265486725663717
GO:BP GO:2000145 regulation of cell motility 0.005792894125012 1061 53 11 0.207547169811321 0.0103675777568332
GO:BP GO:0045619 regulation of lymphocyte differentiation 0.005792894125012 180 30 4 0.133333333333333 0.0222222222222222
GO:BP GO:0046394 carboxylic acid biosynthetic process 0.005792894125012 330 7 3 0.428571428571429 0.00909090909090909
GO:BP GO:0035239 tube morphogenesis 0.00582138155530822 950 100 15 0.15 0.0157894736842105
GO:BP GO:0043271 negative regulation of ion transport 0.00608288191625889 349 7 3 0.428571428571429 0.00859598853868195
GO:BP GO:0051247 positive regulation of protein metabolic process 0.00608953674791397 1564 63 15 0.238095238095238 0.00959079283887468
GO:BP GO:0044255 cellular lipid metabolic process 0.00630135472149035 1075 11 5 0.454545454545455 0.00465116279069767
GO:BP GO:0010632 regulation of epithelial cell migration 0.00652933702045197 306 53 6 0.113207547169811 0.0196078431372549
GO:BP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 0.0066803064352051 185 13 3 0.230769230769231 0.0162162162162162
GO:BP GO:0040012 regulation of locomotion 0.00697162628333339 1104 53 11 0.207547169811321 0.00996376811594203
GO:BP GO:0031647 regulation of protein stability 0.00699079739149357 300 36 5 0.138888888888889 0.0166666666666667
GO:BP GO:0002440 production of molecular mediator of immune response 0.00699079739149357 189 13 3 0.230769230769231 0.0158730158730159
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.0070734409893744 365 30 5 0.166666666666667 0.0136986301369863
GO:BP GO:0019752 carboxylic acid metabolic process 0.00714416982321805 1024 7 4 0.571428571428571 0.00390625
GO:BP GO:0044242 cellular lipid catabolic process 0.0072616386936075 232 11 3 0.272727272727273 0.0129310344827586
GO:BP GO:0000165 MAPK cascade 0.00742601592828349 935 13 5 0.384615384615385 0.0053475935828877
GO:BP GO:0006639 acylglycerol metabolic process 0.00749899913662109 141 77 5 0.0649350649350649 0.0354609929078014
GO:BP GO:0030098 lymphocyte differentiation 0.00753738296086382 376 30 5 0.166666666666667 0.0132978723404255
GO:BP GO:0002696 positive regulation of leukocyte activation 0.00753738296086382 412 42 6 0.142857142857143 0.0145631067961165
GO:BP GO:0043436 oxoacid metabolic process 0.00753738296086382 1057 7 4 0.571428571428571 0.00378429517502365
GO:BP GO:0050671 positive regulation of lymphocyte proliferation 0.00753738296086382 141 18 3 0.166666666666667 0.0212765957446809
GO:BP GO:0006638 neutral lipid metabolic process 0.00753738296086382 142 77 5 0.0649350649350649 0.0352112676056338
GO:BP GO:0032946 positive regulation of mononuclear cell proliferation 0.00753738296086382 142 18 3 0.166666666666667 0.0211267605633803
GO:BP GO:0002684 positive regulation of immune system process 0.00759062220928622 1065 7 4 0.571428571428571 0.00375586854460094
GO:BP GO:0051270 regulation of cellular component movement 0.00775848409755023 1141 53 11 0.207547169811321 0.00964066608238387
GO:BP GO:0009914 hormone transport 0.00775848409755023 327 100 8 0.08 0.0244648318042813
GO:BP GO:0048518 positive regulation of biological process 0.00775848409755023 6363 24 17 0.708333333333333 0.00267169574100267
GO:BP GO:0006082 organic acid metabolic process 0.00775848409755023 1090 7 4 0.571428571428571 0.0036697247706422
GO:BP GO:0050867 positive regulation of cell activation 0.00775848409755023 424 42 6 0.142857142857143 0.0141509433962264
GO:BP GO:0050870 positive regulation of T cell activation 0.00775848409755023 219 30 4 0.133333333333333 0.0182648401826484
GO:BP GO:0051235 maintenance of location 0.00775848409755023 337 53 6 0.113207547169811 0.0178041543026706
GO:BP GO:0043410 positive regulation of MAPK cascade 0.00775848409755023 539 13 4 0.307692307692308 0.00742115027829314
GO:BP GO:0018108 peptidyl-tyrosine phosphorylation 0.00775848409755023 385 31 5 0.161290322580645 0.012987012987013
GO:BP GO:0062012 regulation of small molecule metabolic process 0.00775848409755023 447 15 4 0.266666666666667 0.00894854586129754
GO:BP GO:0002474 antigen processing and presentation of peptide antigen via MHC class I 0.00775848409755023 99 65 4 0.0615384615384615 0.0404040404040404
GO:BP GO:0019216 regulation of lipid metabolic process 0.00775848409755023 419 7 3 0.428571428571429 0.00715990453460621
GO:BP GO:0002699 positive regulation of immune effector process 0.00775848409755023 215 13 3 0.230769230769231 0.013953488372093
GO:BP GO:0051239 regulation of multicellular organismal process 0.00775848409755023 2861 63 21 0.333333333333333 0.00734009087731562
GO:BP GO:0032270 positive regulation of cellular protein metabolic process 0.00775848409755023 1477 63 14 0.222222222222222 0.00947867298578199
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 0.00775848409755023 215 13 3 0.230769230769231 0.013953488372093
GO:BP GO:0070665 positive regulation of leukocyte proliferation 0.00775848409755023 155 18 3 0.166666666666667 0.0193548387096774
GO:BP GO:0051701 biological process involved in interaction with host 0.00778129531616584 221 53 5 0.0943396226415094 0.0226244343891403
GO:BP GO:0018212 peptidyl-tyrosine modification 0.00792709439965938 388 31 5 0.161290322580645 0.0128865979381443
GO:BP GO:0072659 protein localization to plasma membrane 0.0079554421216162 283 42 5 0.119047619047619 0.0176678445229682
GO:BP GO:0032924 activin receptor signaling pathway 0.00796928704310156 44 63 3 0.0476190476190476 0.0681818181818182
GO:BP GO:0010565 regulation of cellular ketone metabolic process 0.00814101201439852 194 15 3 0.2 0.0154639175257732
GO:BP GO:0051240 positive regulation of multicellular organismal process 0.00814101201439852 1455 103 19 0.184466019417476 0.0130584192439863
GO:BP GO:0042127 regulation of cell population proliferation 0.00826067992578735 1774 99 21 0.212121212121212 0.0118376550169109
GO:BP GO:0040011 locomotion 0.00826067992578735 2028 53 15 0.283018867924528 0.00739644970414201
GO:BP GO:0022612 gland morphogenesis 0.00828215498782225 120 24 3 0.125 0.025
GO:BP GO:0034341 response to interferon-gamma 0.00850420509736457 196 35 4 0.114285714285714 0.0204081632653061
GO:BP GO:0030334 regulation of cell migration 0.00862886353645332 999 53 10 0.188679245283019 0.01001001001001
GO:BP GO:0010464 regulation of mesenchymal cell proliferation 0.00884455036713205 30 99 3 0.0303030303030303 0.1
GO:BP GO:0071702 organic substance transport 0.00884455036713205 2766 18 9 0.5 0.00325379609544469
GO:BP GO:0051051 negative regulation of transport 0.00884455036713205 474 7 3 0.428571428571429 0.00632911392405063
GO:BP GO:0001934 positive regulation of protein phosphorylation 0.00884455036713205 840 52 9 0.173076923076923 0.0107142857142857
GO:BP GO:0010883 regulation of lipid storage 0.00889848437269148 56 53 3 0.0566037735849057 0.0535714285714286
GO:BP GO:0046634 regulation of alpha-beta T cell activation 0.00939619309046018 102 30 3 0.1 0.0294117647058824
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 0.00943893422706492 241 30 4 0.133333333333333 0.016597510373444
GO:BP GO:1903131 mononuclear cell differentiation 0.00943893422706492 430 30 5 0.166666666666667 0.0116279069767442
GO:BP GO:0001932 regulation of protein phosphorylation 0.00953707924520175 1240 52 11 0.211538461538462 0.00887096774193548
GO:BP GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 0.00971732907457376 251 13 3 0.230769230769231 0.0119521912350598
GO:BP GO:0022409 positive regulation of cell-cell adhesion 0.0097657822826182 284 94 7 0.074468085106383 0.0246478873239437
GO:BP GO:0045785 positive regulation of cell adhesion 0.0097657822826182 437 30 5 0.166666666666667 0.011441647597254
GO:BP GO:0042098 T cell proliferation 0.00976609787013596 205 94 6 0.0638297872340425 0.0292682926829268
GO:BP GO:1903900 regulation of viral life cycle 0.00982451689461509 153 21 3 0.142857142857143 0.0196078431372549
GO:BP GO:0010631 epithelial cell migration 0.00986000063000934 370 53 6 0.113207547169811 0.0162162162162162
GO:BP GO:0048523 negative regulation of cellular process 0.00986000063000934 5139 84 38 0.452380952380952 0.00739443471492508
GO:BP GO:0090132 epithelium migration 0.0102353266789206 373 53 6 0.113207547169811 0.0160857908847185
GO:BP GO:0002376 immune system process 0.0105044108414719 3278 54 20 0.37037037037037 0.0061012812690665
GO:BP GO:0002274 myeloid leukocyte activation 0.010546462694635 667 42 7 0.166666666666667 0.0104947526236882
GO:BP GO:0006820 anion transport 0.0107612108089089 2889 18 9 0.5 0.00311526479750779
GO:BP GO:0090130 tissue migration 0.0107612108089089 379 53 6 0.113207547169811 0.0158311345646438
GO:BP GO:0098869 cellular oxidant detoxification 0.0113507039553038 100 34 3 0.0882352941176471 0.03
GO:BP GO:0002682 regulation of immune system process 0.0114668858096882 1617 42 11 0.261904761904762 0.00680272108843537
GO:BP GO:0030099 myeloid cell differentiation 0.011612546456246 428 19 4 0.210526315789474 0.00934579439252336
GO:BP GO:0045777 positive regulation of blood pressure 0.0116271620668338 42 82 3 0.0365853658536585 0.0714285714285714
GO:BP GO:0006811 ion transport 0.0121949941414626 3661 18 10 0.555555555555556 0.00273149412728763
GO:BP GO:0002285 lymphocyte activation involved in immune response 0.0121949941414626 190 19 3 0.157894736842105 0.0157894736842105
GO:BP GO:0046486 glycerolipid metabolic process 0.0121949941414626 436 19 4 0.210526315789474 0.00917431192660551
GO:BP GO:0009888 tissue development 0.0121949941414626 2107 24 9 0.375 0.00427147603227337
GO:BP GO:0006468 protein phosphorylation 0.0121949941414626 1668 88 18 0.204545454545455 0.0107913669064748
GO:BP GO:0009749 response to glucose 0.0121949941414626 202 18 3 0.166666666666667 0.0148514851485149
GO:BP GO:0006897 endocytosis 0.0124419714080172 696 31 6 0.193548387096774 0.00862068965517241
GO:BP GO:0006629 lipid metabolic process 0.0124420052900059 1457 11 5 0.454545454545455 0.00343170899107756
GO:BP GO:0007249 I-kappaB kinase/NF-kappaB signaling 0.0125831425349503 291 13 3 0.230769230769231 0.0103092783505155
GO:BP GO:0016042 lipid catabolic process 0.0125831425349503 349 11 3 0.272727272727273 0.00859598853868195
GO:BP GO:1990778 protein localization to cell periphery 0.0126808582195275 338 42 5 0.119047619047619 0.014792899408284
GO:BP GO:0009746 response to hexose 0.0129023485046571 209 18 3 0.166666666666667 0.0143540669856459
GO:BP GO:0050868 negative regulation of T cell activation 0.0129023485046571 123 30 3 0.1 0.024390243902439
GO:BP GO:0007584 response to nutrient 0.0131038934831944 182 21 3 0.142857142857143 0.0164835164835165
GO:BP GO:0042327 positive regulation of phosphorylation 0.0131038934831944 927 52 9 0.173076923076923 0.00970873786407767
GO:BP GO:0034284 response to monosaccharide 0.013140951866703 215 18 3 0.166666666666667 0.013953488372093
GO:BP GO:1990748 cellular detoxification 0.0135316447217915 113 34 3 0.0882352941176471 0.0265486725663717
GO:BP GO:0030155 regulation of cell adhesion 0.0135316447217915 748 52 8 0.153846153846154 0.0106951871657754
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 0.0135368745425198 309 13 3 0.230769230769231 0.00970873786407767
GO:BP GO:1902105 regulation of leukocyte differentiation 0.0135368745425198 288 30 4 0.133333333333333 0.0138888888888889
GO:BP GO:0042180 cellular ketone metabolic process 0.0140642998127747 271 15 3 0.2 0.011070110701107
GO:BP GO:0000302 response to reactive oxygen species 0.0140642998127747 237 17 3 0.176470588235294 0.0126582278481013
GO:BP GO:0050896 response to stimulus 0.0140642998127747 9407 55 40 0.727272727272727 0.00425215265228022
GO:BP GO:0007165 signal transduction 0.0140779934421356 6309 9 8 0.888888888888889 0.00126802979870027
GO:BP GO:0006810 transport 0.0140779934421356 5224 58 28 0.482758620689655 0.00535987748851455
GO:BP GO:0080090 regulation of primary metabolic process 0.0140779934421356 6053 31 19 0.612903225806452 0.00313893936890798
GO:BP GO:0050792 regulation of viral process 0.0140826483761271 192 21 3 0.142857142857143 0.015625
GO:BP GO:0032502 developmental process 0.0143099603194416 6628 25 17 0.68 0.00256487628243814
GO:BP GO:0043408 regulation of MAPK cascade 0.0143099603194416 730 13 4 0.307692307692308 0.00547945205479452
GO:BP GO:0009966 regulation of signal transduction 0.0146855999852645 3165 9 6 0.666666666666667 0.0018957345971564
GO:BP GO:0097237 cellular response to toxic substance 0.0146855999852645 120 34 3 0.0882352941176471 0.025
GO:BP GO:0051249 regulation of lymphocyte activation 0.0146855999852645 518 18 4 0.222222222222222 0.00772200772200772
GO:BP GO:0030837 negative regulation of actin filament polymerization 0.0147449615887874 68 60 3 0.05 0.0441176470588235
GO:BP GO:0070371 ERK1 and ERK2 cascade 0.0147449615887874 329 13 3 0.230769230769231 0.00911854103343465
GO:BP GO:0035295 tube development 0.0149189325506621 1146 100 15 0.15 0.0130890052356021
GO:BP GO:1902533 positive regulation of intracellular signal transduction 0.0151616259283922 1037 16 5 0.3125 0.00482160077145612
GO:BP GO:0060389 pathway-restricted SMAD protein phosphorylation 0.0151616259283922 66 63 3 0.0476190476190476 0.0454545454545455
GO:BP GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II 0.0151616259283922 96 94 4 0.0425531914893617 0.0416666666666667
GO:BP GO:0043903 regulation of biological process involved in symbiotic interaction 0.0153013256608341 203 21 3 0.142857142857143 0.0147783251231527
GO:BP GO:1903038 negative regulation of leukocyte cell-cell adhesion 0.0156844845879427 142 30 3 0.1 0.0211267605633803
GO:BP GO:0002446 neutrophil mediated immunity 0.016131051519606 497 47 6 0.127659574468085 0.0120724346076459
GO:BP GO:0002443 leukocyte mediated immunity 0.016131051519606 877 47 8 0.170212765957447 0.00912200684150513
GO:BP GO:0009967 positive regulation of signal transduction 0.016131051519606 1598 16 6 0.375 0.00375469336670839
GO:BP GO:0023052 signaling 0.016131051519606 6810 21 15 0.714285714285714 0.00220264317180617
GO:BP GO:0007154 cell communication 0.016303938006764 6829 21 15 0.714285714285714 0.00219651486308391
GO:BP GO:0002495 antigen processing and presentation of peptide antigen via MHC class II 0.0165282263075009 100 94 4 0.0425531914893617 0.04
GO:BP GO:0044283 small molecule biosynthetic process 0.0165282263075009 704 7 3 0.428571428571429 0.00426136363636364
GO:BP GO:0046879 hormone secretion 0.0168053065312687 317 100 7 0.07 0.0220820189274448
GO:BP GO:0006954 inflammatory response 0.0170078936776112 794 13 4 0.307692307692308 0.00503778337531486
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 0.0170289343631388 1001 52 9 0.173076923076923 0.00899100899100899
GO:BP GO:0006892 post-Golgi vesicle-mediated transport 0.0170289343631388 108 42 3 0.0714285714285714 0.0277777777777778
GO:BP GO:0002521 leukocyte differentiation 0.0170289343631388 550 30 5 0.166666666666667 0.00909090909090909
GO:BP GO:0098754 detoxification 0.0170289343631388 134 34 3 0.0882352941176471 0.0223880597014925
GO:BP GO:0045937 positive regulation of phosphate metabolic process 0.0170289343631388 1001 52 9 0.173076923076923 0.00899100899100899
GO:BP GO:0010038 response to metal ion 0.0170289343631388 371 64 6 0.09375 0.0161725067385445
GO:BP GO:0009612 response to mechanical stimulus 0.0170289343631388 218 21 3 0.142857142857143 0.0137614678899083
GO:BP GO:0006928 movement of cell or subcellular component 0.0170289343631388 2311 53 15 0.283018867924528 0.00649069666810904
GO:BP GO:0019915 lipid storage 0.0171946518436109 86 53 3 0.0566037735849057 0.0348837209302326
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0171963104420827 810 13 4 0.307692307692308 0.00493827160493827
GO:BP GO:0008610 lipid biosynthetic process 0.0175011058646615 740 7 3 0.428571428571429 0.00405405405405405
GO:BP GO:0051234 establishment of localization 0.0175731911089912 5372 58 28 0.482758620689655 0.00521221146686523
GO:BP GO:0042325 regulation of phosphorylation 0.0175731911089912 1431 52 11 0.211538461538462 0.0076869322152341
GO:BP GO:0051250 negative regulation of lymphocyte activation 0.0176896313323089 156 30 3 0.1 0.0192307692307692
GO:BP GO:0031323 regulation of cellular metabolic process 0.0176896313323089 6269 31 19 0.612903225806452 0.00303078640931568
GO:BP GO:0002791 regulation of peptide secretion 0.0176903180959378 325 100 7 0.07 0.0215384615384615
GO:BP GO:1901264 carbohydrate derivative transport 0.0177376677176559 88 53 3 0.0566037735849057 0.0340909090909091
GO:BP GO:0046889 positive regulation of lipid biosynthetic process 0.0177376677176559 88 53 3 0.0566037735849057 0.0340909090909091
GO:BP GO:0050863 regulation of T cell activation 0.0177781499863242 337 30 4 0.133333333333333 0.0118694362017804
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 0.0178223049674173 338 30 4 0.133333333333333 0.0118343195266272
GO:BP GO:0042129 regulation of T cell proliferation 0.0178486709289889 176 94 5 0.0531914893617021 0.0284090909090909
GO:BP GO:0045597 positive regulation of cell differentiation 0.0178486709289889 879 20 5 0.25 0.00568828213879408
GO:BP GO:0002790 peptide secretion 0.0179258222792711 421 100 8 0.08 0.0190023752969121
GO:BP GO:0019220 regulation of phosphate metabolic process 0.018286142434594 1645 53 12 0.226415094339623 0.00729483282674772
GO:BP GO:0051174 regulation of phosphorus metabolic process 0.018286142434594 1645 53 12 0.226415094339623 0.00729483282674772
GO:BP GO:0032680 regulation of tumor necrosis factor production 0.018286142434594 163 103 5 0.0485436893203883 0.0306748466257669
GO:BP GO:0006955 immune response 0.018370596744794 2311 54 15 0.277777777777778 0.00649069666810904
GO:BP GO:0032640 tumor necrosis factor production 0.0188321615098645 165 103 5 0.0485436893203883 0.0303030303030303
GO:BP GO:0031663 lipopolysaccharide-mediated signaling pathway 0.0189317696225786 56 88 3 0.0340909090909091 0.0535714285714286
GO:BP GO:0032272 negative regulation of protein polymerization 0.0189317696225786 82 60 3 0.05 0.0365853658536585
GO:BP GO:0051094 positive regulation of developmental process 0.0189317696225786 1341 20 6 0.3 0.00447427293064877
GO:BP GO:0002694 regulation of leukocyte activation 0.0191304132690257 610 42 6 0.142857142857143 0.00983606557377049
GO:BP GO:0007600 sensory perception 0.0191304132690257 958 6 3 0.5 0.00313152400835073
GO:BP GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 0.0191304132690257 167 103 5 0.0485436893203883 0.029940119760479
GO:BP GO:0010646 regulation of cell communication 0.0193673447239369 3543 9 6 0.666666666666667 0.00169348010160881
GO:BP GO:0009605 response to external stimulus 0.0194576106906674 2944 24 10 0.416666666666667 0.00339673913043478
GO:BP GO:0042592 homeostatic process 0.019503603297597 1981 57 14 0.245614035087719 0.00706713780918728
GO:BP GO:0072593 reactive oxygen species metabolic process 0.0196173134961682 290 18 3 0.166666666666667 0.0103448275862069
GO:BP GO:0023051 regulation of signaling 0.0198652521839572 3578 9 6 0.666666666666667 0.00167691447736165
GO:BP GO:0051246 regulation of protein metabolic process 0.0198652521839572 2704 52 16 0.307692307692308 0.00591715976331361
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.0198652521839572 551 47 6 0.127659574468085 0.0108892921960073
GO:BP GO:0071706 tumor necrosis factor superfamily cytokine production 0.0198652521839572 170 103 5 0.0485436893203883 0.0294117647058824
GO:BP GO:0060395 SMAD protein signal transduction 0.0201453644808504 82 63 3 0.0476190476190476 0.0365853658536585
GO:BP GO:0044070 regulation of anion transport 0.0201453644808504 896 13 4 0.307692307692308 0.00446428571428571
GO:BP GO:0010647 positive regulation of cell communication 0.0201453644808504 1777 16 6 0.375 0.00337647720877884
GO:BP GO:0002252 immune effector process 0.0201453644808504 1309 21 6 0.285714285714286 0.00458365164247517
GO:BP GO:0032101 regulation of response to external stimulus 0.0201453644808504 1051 18 5 0.277777777777778 0.00475737392959087
GO:BP GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I 0.0201453644808504 80 65 3 0.0461538461538462 0.0375
GO:BP GO:0023056 positive regulation of signaling 0.0203527124593806 1782 16 6 0.375 0.00336700336700337
GO:BP GO:0097305 response to alcohol 0.0203651613410408 255 21 3 0.142857142857143 0.0117647058823529
GO:BP GO:0001667 ameboidal-type cell migration 0.0206785243942738 494 53 6 0.113207547169811 0.0121457489878543
GO:BP GO:0060341 regulation of cellular localization 0.0209712511435986 851 42 7 0.166666666666667 0.0082256169212691
GO:BP GO:0016485 protein processing 0.0211157054945838 235 47 4 0.0851063829787234 0.0170212765957447
GO:BP GO:0030072 peptide hormone secretion 0.0211599947323783 260 100 6 0.06 0.0230769230769231
GO:BP GO:0031401 positive regulation of protein modification process 0.0211738522616084 1074 52 9 0.173076923076923 0.00837988826815642
GO:BP GO:0007159 leukocyte cell-cell adhesion 0.021335583622742 375 30 4 0.133333333333333 0.0106666666666667
GO:BP GO:0042060 wound healing 0.0215482823313494 549 21 4 0.19047619047619 0.00728597449908925
GO:BP GO:0050790 regulation of catalytic activity 0.0215482823313494 2545 102 25 0.245098039215686 0.00982318271119843
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 0.0217052972816801 3083 31 12 0.387096774193548 0.00389231268245216
GO:BP GO:0050865 regulation of cell activation 0.0223059244925544 655 18 4 0.222222222222222 0.00610687022900763
GO:BP GO:0031638 zymogen activation 0.0223847642541055 58 95 3 0.0315789473684211 0.0517241379310345
GO:BP GO:0009893 positive regulation of metabolic process 0.0226632711758309 3783 53 20 0.377358490566038 0.00528680941052075
GO:BP GO:0019058 viral life cycle 0.0226799781379641 353 53 5 0.0943396226415094 0.0141643059490085
GO:BP GO:0002695 negative regulation of leukocyte activation 0.0226799781379641 188 30 3 0.1 0.0159574468085106
GO:BP GO:0045765 regulation of angiogenesis 0.0228895432939114 358 100 7 0.07 0.0195530726256983
GO:BP GO:0002062 chondrocyte differentiation 0.0228895432939114 108 52 3 0.0576923076923077 0.0277777777777778
GO:BP GO:0045766 positive regulation of angiogenesis 0.0232196432304819 187 100 5 0.05 0.0267379679144385
GO:BP GO:0001525 angiogenesis 0.0232196432304819 617 59 7 0.11864406779661 0.0113452188006483
GO:BP GO:0097006 regulation of plasma lipoprotein particle levels 0.0232196432304819 107 53 3 0.0566037735849057 0.0280373831775701
GO:BP GO:1904018 positive regulation of vasculature development 0.0232196432304819 187 100 5 0.05 0.0267379679144385
GO:BP GO:0002697 regulation of immune effector process 0.0234575075298419 461 13 3 0.230769230769231 0.00650759219088937
GO:BP GO:0010035 response to inorganic substance 0.0235707891764111 575 21 4 0.19047619047619 0.00695652173913044
GO:BP GO:0022408 negative regulation of cell-cell adhesion 0.0235707891764111 194 30 3 0.1 0.0154639175257732
GO:BP GO:1901342 regulation of vasculature development 0.0238899509743605 364 100 7 0.07 0.0192307692307692
GO:BP GO:0072657 protein localization to membrane 0.0239499428662576 665 42 6 0.142857142857143 0.00902255639097744
GO:BP GO:0031325 positive regulation of cellular metabolic process 0.0239861181805125 3274 57 19 0.333333333333333 0.00580329871716555
GO:BP GO:0048519 negative regulation of biological process 0.0239861181805125 5757 30 17 0.566666666666667 0.00295292687163453
GO:BP GO:0046883 regulation of hormone secretion 0.0239995498970298 275 100 6 0.06 0.0218181818181818
GO:BP GO:0014070 response to organic cyclic compound 0.0240969037045477 967 21 5 0.238095238095238 0.00517063081695967
GO:BP GO:0030301 cholesterol transport 0.0241698227068457 112 53 3 0.0566037735849057 0.0267857142857143
GO:BP GO:0007166 cell surface receptor signaling pathway 0.0242575735219727 3210 20 9 0.45 0.00280373831775701
GO:BP GO:0071705 nitrogen compound transport 0.0242575735219727 2322 22 8 0.363636363636364 0.00344530577088717
GO:BP GO:0065008 regulation of biological quality 0.024583680481555 4131 53 21 0.39622641509434 0.00508351488743646
GO:BP GO:0007167 enzyme linked receptor protein signaling pathway 0.0248498328537847 1103 63 10 0.158730158730159 0.00906618313689937
GO:BP GO:0071346 cellular response to interferon-gamma 0.0251688666075656 175 35 3 0.0857142857142857 0.0171428571428571
GO:BP GO:0042113 B cell activation 0.0252732462662189 330 19 3 0.157894736842105 0.00909090909090909
GO:BP GO:0045123 cellular extravasation 0.0256827586557531 70 88 3 0.0340909090909091 0.0428571428571429
GO:BP GO:0030324 lung development 0.025878998556594 173 36 3 0.0833333333333333 0.0173410404624277
GO:BP GO:1903706 regulation of hemopoiesis 0.0259848023376247 424 30 4 0.133333333333333 0.00943396226415094
GO:BP GO:0050866 negative regulation of cell activation 0.0259848023376247 211 30 3 0.1 0.014218009478673
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 0.0261768613146252 1202 59 10 0.169491525423729 0.00831946755407654
GO:BP GO:0030323 respiratory tube development 0.0265390410366007 177 36 3 0.0833333333333333 0.0169491525423729
GO:BP GO:0065009 regulation of molecular function 0.0268033817551691 3221 102 29 0.284313725490196 0.00900341508848184
GO:BP GO:0042221 response to chemical 0.0271106957646341 4781 53 23 0.433962264150943 0.0048107090566827
GO:BP GO:0030858 positive regulation of epithelial cell differentiation 0.0271106957646341 67 96 3 0.03125 0.0447761194029851
GO:BP GO:0032720 negative regulation of tumor necrosis factor production 0.0271106957646341 73 88 3 0.0340909090909091 0.0410958904109589
GO:BP GO:0043269 regulation of ion transport 0.0272122913733266 1379 16 5 0.3125 0.00362581580855693
GO:BP GO:0018193 peptidyl-amino acid modification 0.0276286206962624 1303 31 7 0.225806451612903 0.00537221795855718
GO:BP GO:0048870 cell motility 0.0279257325248963 1828 53 12 0.226415094339623 0.00656455142231947
GO:BP GO:0051674 localization of cell 0.0279257325248963 1828 53 12 0.226415094339623 0.00656455142231947
GO:BP GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 0.028414112184065 75 88 3 0.0340909090909091 0.04
GO:BP GO:0015918 sterol transport 0.0284685687814139 125 53 3 0.0566037735849057 0.024
GO:BP GO:0022407 regulation of cell-cell adhesion 0.0286489798236112 445 30 4 0.133333333333333 0.00898876404494382
GO:BP GO:0046887 positive regulation of hormone secretion 0.0286489798236112 133 98 4 0.0408163265306122 0.0300751879699248
GO:BP GO:0010950 positive regulation of endopeptidase activity 0.0288766520031565 187 36 3 0.0833333333333333 0.0160427807486631
GO:BP GO:0001817 regulation of cytokine production 0.0291222440933358 806 103 11 0.106796116504854 0.0136476426799007
GO:BP GO:0050886 endocrine process 0.0292380327169575 82 82 3 0.0365853658536585 0.0365853658536585
GO:BP GO:0007568 aging 0.0293855437225051 329 21 3 0.142857142857143 0.00911854103343465
GO:BP GO:0035773 insulin secretion involved in cellular response to glucose stimulus 0.0294306580589805 69 98 3 0.0306122448979592 0.0434782608695652
GO:BP GO:0048856 anatomical structure development 0.0296067013544034 6106 25 15 0.6 0.00245660006550934
GO:BP GO:0016310 phosphorylation 0.0296728757534801 2138 88 19 0.215909090909091 0.00888681010289991
GO:BP GO:0051716 cellular response to stimulus 0.0299308030153153 7781 9 8 0.888888888888889 0.00102814548258579
GO:BP GO:0051301 cell division 0.0299308030153153 622 49 6 0.122448979591837 0.00964630225080386
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 0.0299308030153153 3483 52 18 0.346153846153846 0.00516795865633075
GO:BP GO:0051341 regulation of oxidoreductase activity 0.0299308030153153 118 58 3 0.0517241379310345 0.0254237288135593
GO:BP GO:0006952 defense response 0.0299637300388417 1818 13 5 0.384615384615385 0.00275027502750275
GO:BP GO:0042493 response to drug 0.0299752524867549 396 18 3 0.166666666666667 0.00757575757575758
GO:BP GO:0031399 regulation of protein modification process 0.0307152344192566 1671 52 11 0.211538461538462 0.00658288450029922
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0307152344192566 1132 13 4 0.307692307692308 0.00353356890459364
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 0.0307152344192566 369 83 6 0.072289156626506 0.016260162601626
GO:BP GO:0009611 response to wounding 0.0307152344192566 674 21 4 0.19047619047619 0.00593471810089021
GO:BP GO:0050673 epithelial cell proliferation 0.0309437391641837 460 67 6 0.0895522388059701 0.0130434782608696
GO:BP GO:0016477 cell migration 0.0311870669275918 1649 20 6 0.3 0.00363856882959369
GO:BP GO:0060541 respiratory system development 0.0311870669275918 199 36 3 0.0833333333333333 0.0150753768844221
GO:BP GO:0090087 regulation of peptide transport 0.0311870669275918 618 100 9 0.09 0.0145631067961165
GO:BP GO:0030073 insulin secretion 0.0314015486658044 218 100 5 0.05 0.0229357798165138
GO:BP GO:0010942 positive regulation of cell death 0.0314382419282465 684 21 4 0.19047619047619 0.00584795321637427
GO:BP GO:0051259 protein complex oligomerization 0.0316076637474869 234 31 3 0.0967741935483871 0.0128205128205128
GO:BP GO:0050776 regulation of immune response 0.0318103260851584 996 42 7 0.166666666666667 0.0070281124497992
GO:BP GO:0048583 regulation of response to stimulus 0.0318103260851584 4278 9 6 0.666666666666667 0.00140252454417952
GO:BP GO:0090276 regulation of peptide hormone secretion 0.0325304658533311 221 100 5 0.05 0.0226244343891403
GO:BP GO:0010952 positive regulation of peptidase activity 0.0327100284821365 205 36 3 0.0833333333333333 0.0146341463414634
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 0.0327100284821365 5848 31 17 0.548387096774194 0.00290697674418605
GO:BP GO:0046903 secretion 0.0329580275764373 1501 100 16 0.16 0.0106595602931379
GO:BP GO:0051604 protein maturation 0.033339333363562 306 47 4 0.0851063829787234 0.0130718954248366
GO:BP GO:0048514 blood vessel morphogenesis 0.0333693240186561 711 59 7 0.11864406779661 0.00984528832630099
GO:BP GO:0050877 nervous system process 0.0334538841060504 1426 6 3 0.5 0.00210378681626928
GO:BP GO:0051279 regulation of release of sequestered calcium ion into cytosol 0.0336890506109673 85 88 3 0.0340909090909091 0.0352941176470588
GO:BP GO:0051651 maintenance of location in cell 0.0339352532018568 223 34 3 0.0882352941176471 0.0134529147982063
GO:BP GO:0051048 negative regulation of secretion 0.0339352532018568 176 82 4 0.0487804878048781 0.0227272727272727
GO:BP GO:0032268 regulation of cellular protein metabolic process 0.0339352532018568 2541 36 11 0.305555555555556 0.00432900432900433
GO:BP GO:0051049 regulation of transport 0.0341289439280385 1809 63 13 0.206349206349206 0.00718629076838032
GO:BP GO:0019222 regulation of metabolic process 0.0341289439280385 7148 53 30 0.566037735849057 0.00419697817571349
GO:BP GO:0001816 cytokine production 0.0341289439280385 844 103 11 0.106796116504854 0.0130331753554502
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 0.0345585402553886 147 99 4 0.0404040404040404 0.0272108843537415
GO:BP GO:0016192 vesicle-mediated transport 0.0347738397295445 2180 53 13 0.245283018867925 0.00596330275229358
GO:BP GO:0048878 chemical homeostasis 0.0347975424135949 1229 53 9 0.169811320754717 0.00732302685109845
GO:BP GO:0006979 response to oxidative stress 0.034840739034852 466 17 3 0.176470588235294 0.00643776824034335
GO:BP GO:0034097 response to cytokine 0.034840739034852 1226 7 3 0.428571428571429 0.00244698205546493
GO:BP GO:0008285 negative regulation of cell population proliferation 0.0351172464341165 790 30 5 0.166666666666667 0.00632911392405063
GO:BP GO:0051649 establishment of localization in cell 0.0352518096964671 2813 42 13 0.30952380952381 0.00462140063988624
GO:BP GO:0043549 regulation of kinase activity 0.0354016807133796 921 47 7 0.148936170212766 0.00760043431053203
GO:BP GO:0008544 epidermis development 0.0355905460785027 475 17 3 0.176470588235294 0.00631578947368421
GO:BP GO:0019725 cellular homeostasis 0.0355905460785027 981 16 4 0.25 0.00407747196738022
GO:BP GO:0044093 positive regulation of molecular function 0.0357099782801427 1771 58 12 0.206896551724138 0.00677583286278938
GO:BP GO:0033036 macromolecule localization 0.0357701871064255 3218 22 9 0.409090909090909 0.00279676817899316
GO:BP GO:0048754 branching morphogenesis of an epithelial tube 0.0360822320697597 151 99 4 0.0404040404040404 0.0264900662251656
GO:BP GO:0007009 plasma membrane organization 0.0360822320697597 116 68 3 0.0441176470588235 0.0258620689655172
GO:BP GO:0051046 regulation of secretion 0.0360968649171378 647 100 9 0.09 0.0139103554868624
GO:BP GO:0051241 negative regulation of multicellular organismal process 0.0377357958154343 1160 88 12 0.136363636363636 0.0103448275862069
GO:BP GO:0007267 cell-cell signaling 0.0381285820963692 1722 15 5 0.333333333333333 0.00290360046457607
GO:BP GO:0051641 cellular localization 0.0385993429903003 3541 42 15 0.357142857142857 0.00423609149957639
GO:BP GO:0009636 response to toxic substance 0.0386550063469837 243 34 3 0.0882352941176471 0.0123456790123457
GO:BP GO:0045834 positive regulation of lipid metabolic process 0.0387115325776934 155 53 3 0.0566037735849057 0.0193548387096774
GO:BP GO:0032649 regulation of interferon-gamma production 0.0391703033607817 110 75 3 0.04 0.0272727272727273
GO:BP GO:0050794 regulation of cellular process 0.0397876195670331 11473 31 26 0.838709677419355 0.00226619018565327
GO:BP GO:0007162 negative regulation of cell adhesion 0.0400774823939365 304 52 4 0.0769230769230769 0.0131578947368421
GO:BP GO:0006950 response to stress 0.0400774823939365 4170 18 9 0.5 0.00215827338129496
GO:BP GO:1905475 regulation of protein localization to membrane 0.0401709326848295 201 42 3 0.0714285714285714 0.0149253731343284
GO:BP GO:0030856 regulation of epithelial cell differentiation 0.0402944126589289 164 96 4 0.0416666666666667 0.024390243902439
GO:BP GO:0033993 response to lipid 0.0404099940676315 918 18 4 0.222222222222222 0.00435729847494553
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 0.0406378565884023 1967 24 7 0.291666666666667 0.00355871886120996
GO:BP GO:0008217 regulation of blood pressure 0.0406378565884023 193 82 4 0.0487804878048781 0.0207253886010363
GO:BP GO:0048584 positive regulation of response to stimulus 0.0410932269559538 2344 16 6 0.375 0.00255972696245734
GO:BP GO:1901700 response to oxygen-containing compound 0.0414223318797086 1739 21 6 0.285714285714286 0.00345025876940771
GO:BP GO:0032609 interferon-gamma production 0.0416740574364812 115 75 3 0.04 0.0260869565217391
GO:BP GO:0008284 positive regulation of cell population proliferation 0.0429911545701785 982 94 11 0.117021276595745 0.0112016293279022
GO:BP GO:0009891 positive regulation of biosynthetic process 0.0429911545701785 2004 24 7 0.291666666666667 0.00349301397205589
GO:BP GO:2000026 regulation of multicellular organismal development 0.0434013819788764 1447 100 15 0.15 0.0103662750518314
GO:BP GO:0032501 multicellular organismal process 0.0434013819788764 7946 25 17 0.68 0.00213944122829096
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.0438768039528093 325 51 4 0.0784313725490196 0.0123076923076923
GO:BP GO:0048661 positive regulation of smooth muscle cell proliferation 0.0450792120335813 103 88 3 0.0340909090909091 0.029126213592233
GO:BP GO:0080134 regulation of response to stress 0.0450792120335813 1443 7 3 0.428571428571429 0.00207900207900208
GO:BP GO:0043085 positive regulation of catalytic activity 0.0450792120335813 1418 58 10 0.172413793103448 0.00705218617771509
GO:BP GO:0001568 blood vessel development 0.0455544120462446 792 59 7 0.11864406779661 0.00883838383838384
GO:BP GO:0010628 positive regulation of gene expression 0.0460385971439093 1160 103 13 0.12621359223301 0.0112068965517241
GO:BP GO:0030097 hemopoiesis 0.0460462049584422 928 19 4 0.210526315789474 0.00431034482758621
GO:BP GO:0050680 negative regulation of epithelial cell proliferation 0.0464723646823835 178 52 3 0.0576923076923077 0.0168539325842697
GO:BP GO:0034613 cellular protein localization 0.046865629827007 2014 42 10 0.238095238095238 0.00496524329692155
GO:BP GO:0010522 regulation of calcium ion transport into cytosol 0.047025549517429 106 88 3 0.0340909090909091 0.0283018867924528
GO:BP GO:0048660 regulation of smooth muscle cell proliferation 0.0476150145903479 174 99 4 0.0404040404040404 0.0229885057471264
GO:BP GO:0070727 cellular macromolecule localization 0.0476262139145381 2024 42 10 0.238095238095238 0.00494071146245059
GO:BP GO:0048659 smooth muscle cell proliferation 0.0487753158405296 176 99 4 0.0404040404040404 0.0227272727272727
GO:BP GO:0051592 response to calcium ion 0.0495711778071854 151 64 3 0.046875 0.0198675496688742
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.0496911072390515 966 19 4 0.210526315789474 0.0041407867494824
GO:BP GO:0045893 positive regulation of transcription, DNA-templated 0.0498215305857964 1617 24 6 0.25 0.00371057513914657
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 0.0498215305857964 1617 24 6 0.25 0.00371057513914657
GO:BP GO:0051338 regulation of transferase activity 0.0498215305857964 1035 47 7 0.148936170212766 0.00676328502415459
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 0.0499108839712834 1618 24 6 0.25 0.00370828182941904
GO:CC GO:0042613 MHC class II protein complex 3.51103013247357e-06 16 94 5 0.0531914893617021 0.3125
GO:CC GO:0009986 cell surface 1.16470846371953e-05 899 53 14 0.264150943396226 0.0155728587319244
GO:CC GO:0042611 MHC protein complex 1.16470846371953e-05 24 94 5 0.0531914893617021 0.208333333333333
GO:CC GO:0030139 endocytic vesicle 1.22463197144063e-05 306 53 9 0.169811320754717 0.0294117647058824
GO:CC GO:0071944 cell periphery 1.64405282343177e-05 6169 88 52 0.590909090909091 0.00842924298913924
GO:CC GO:0005886 plasma membrane 1.76777653693762e-05 5681 97 53 0.54639175257732 0.00932934342545326
GO:CC GO:0009897 external side of plasma membrane 4.63444348273191e-05 408 50 9 0.18 0.0220588235294118
GO:CC GO:0031410 cytoplasmic vesicle 0.000152327998870145 2424 54 20 0.37037037037037 0.00825082508250825
GO:CC GO:0030666 endocytic vesicle membrane 0.000152327998870145 159 53 6 0.113207547169811 0.0377358490566038
GO:CC GO:0098552 side of membrane 0.000152327998870145 619 50 10 0.2 0.0161550888529887
GO:CC GO:0097708 intracellular vesicle 0.000152327998870145 2428 54 20 0.37037037037037 0.00823723228995058
GO:CC GO:0030659 cytoplasmic vesicle membrane 0.000304431152071931 779 28 8 0.285714285714286 0.0102695763799743
GO:CC GO:0012506 vesicle membrane 0.000316649107310408 800 28 8 0.285714285714286 0.01
GO:CC GO:0070062 extracellular exosome 0.000316649107310408 2176 53 18 0.339622641509434 0.00827205882352941
GO:CC GO:0005768 endosome 0.000347502582915589 987 54 12 0.222222222222222 0.0121580547112462
GO:CC GO:1903561 extracellular vesicle 0.000405202075235026 2261 53 18 0.339622641509434 0.00796107916850951
GO:CC GO:0005901 caveola 0.000405202075235026 83 77 5 0.0649350649350649 0.0602409638554217
GO:CC GO:0043230 extracellular organelle 0.000405202075235026 2263 53 18 0.339622641509434 0.00795404330534688
GO:CC GO:0005764 lysosome 0.000437639780342774 712 54 10 0.185185185185185 0.0140449438202247
GO:CC GO:0000323 lytic vacuole 0.000437639780342774 712 54 10 0.185185185185185 0.0140449438202247
GO:CC GO:0030667 secretory granule membrane 0.000559673491987091 303 5 3 0.6 0.0099009900990099
GO:CC GO:0031982 vesicle 0.000559673491987091 4055 54 25 0.462962962962963 0.0061652281134402
GO:CC GO:0005770 late endosome 0.000605821001038887 275 45 6 0.133333333333333 0.0218181818181818
GO:CC GO:0005773 vacuole 0.00108016912725847 810 54 10 0.185185185185185 0.0123456790123457
GO:CC GO:0016020 membrane 0.00111718112418225 9838 89 64 0.719101123595506 0.00650538727383615
GO:CC GO:0044853 plasma membrane raft 0.00121815275481314 116 77 5 0.0649350649350649 0.0431034482758621
GO:CC GO:0005615 extracellular space 0.00121815275481314 3594 13 9 0.692307692307692 0.00250417362270451
GO:CC GO:0031090 organelle membrane 0.00263889834674419 3612 7 6 0.857142857142857 0.00166112956810631
GO:CC GO:0098588 bounding membrane of organelle 0.00291977470988461 2158 7 5 0.714285714285714 0.00231696014828545
GO:CC GO:0030658 transport vesicle membrane 0.00301643083324785 209 13 3 0.230769230769231 0.0143540669856459
GO:CC GO:0045335 phagocytic vesicle 0.0035270012672261 137 49 4 0.0816326530612245 0.0291970802919708
GO:CC GO:0031226 intrinsic component of plasma membrane 0.00369993975136094 1726 22 8 0.363636363636364 0.00463499420625724
GO:CC GO:0010008 endosome membrane 0.0042652709133883 505 54 7 0.12962962962963 0.0138613861386139
GO:CC GO:0005802 trans-Golgi network 0.00447046422194553 250 13 3 0.230769230769231 0.012
GO:CC GO:0016021 integral component of membrane 0.00474057900758729 5711 54 28 0.518518518518518 0.00490281912099457
GO:CC GO:0005765 lysosomal membrane 0.00474057900758729 383 54 6 0.111111111111111 0.0156657963446475
GO:CC GO:0005576 extracellular region 0.00474057900758729 4567 13 9 0.692307692307692 0.00197065907597986
GO:CC GO:0098852 lytic vacuole membrane 0.00474057900758729 383 54 6 0.111111111111111 0.0156657963446475
GO:CC GO:0030141 secretory granule 0.00525276385402672 851 5 3 0.6 0.00352526439482961
GO:CC GO:0031224 intrinsic component of membrane 0.00654031519519527 5868 54 28 0.518518518518518 0.00477164280845262
GO:CC GO:0005783 endoplasmic reticulum 0.00654031519519527 1982 9 5 0.555555555555556 0.00252270433905146
GO:CC GO:0012505 endomembrane system 0.00686947719432966 4640 9 7 0.777777777777778 0.00150862068965517
GO:CC GO:0099503 secretory vesicle 0.00826448716355184 1020 5 3 0.6 0.00294117647058824
GO:CC GO:0031301 integral component of organelle membrane 0.00832473086022528 382 25 4 0.16 0.0104712041884817
GO:CC GO:0030665 clathrin-coated vesicle membrane 0.00841817053641108 114 82 4 0.0487804878048781 0.0350877192982456
GO:CC GO:0005774 vacuolar membrane 0.00841817053641108 441 54 6 0.111111111111111 0.0136054421768707
GO:CC GO:0005887 integral component of plasma membrane 0.00952041396398364 1645 22 7 0.318181818181818 0.00425531914893617
GO:CC GO:0031300 intrinsic component of organelle membrane 0.00952041396398364 413 25 4 0.16 0.00968523002421308
GO:CC GO:0048471 perinuclear region of cytoplasm 0.010218005251455 735 88 10 0.113636363636364 0.0136054421768707
GO:CC GO:0098590 plasma membrane region 0.0115852356615728 1240 5 3 0.6 0.00241935483870968
GO:CC GO:0030133 transport vesicle 0.0115852356615728 414 13 3 0.230769230769231 0.0072463768115942
GO:CC GO:0031902 late endosome membrane 0.0187938051364307 140 45 3 0.0666666666666667 0.0214285714285714
GO:CC GO:0005737 cytoplasm 0.0219874695714012 11911 104 78 0.75 0.00654856855007976
GO:CC GO:0005766 primary lysosome 0.0270406632874674 154 49 3 0.0612244897959184 0.0194805194805195
GO:CC GO:0042582 azurophil granule 0.0270406632874674 154 49 3 0.0612244897959184 0.0194805194805195
GO:CC GO:0042581 specific granule 0.0277043811930984 158 49 3 0.0612244897959184 0.0189873417721519
GO:CC GO:0030864 cortical actin cytoskeleton 0.0292101506202808 79 100 3 0.03 0.0379746835443038
GO:CC GO:0005758 mitochondrial intermembrane space 0.0299510958574147 87 92 3 0.0326086956521739 0.0344827586206897
GO:CC GO:0070820 tertiary granule 0.0310202799543906 163 95 4 0.0421052631578947 0.0245398773006135
GO:CC GO:0031970 organelle envelope lumen 0.0380216352922369 97 92 3 0.0326086956521739 0.0309278350515464
GO:CC GO:0043235 receptor complex 0.039614365207069 522 18 3 0.166666666666667 0.00574712643678161
GO:CC GO:0055037 recycling endosome 0.0412867254411567 188 50 3 0.06 0.0159574468085106
GO:CC GO:0098797 plasma membrane protein complex 0.0418464126669246 694 54 6 0.111111111111111 0.00864553314121038
GO:CC GO:0005794 Golgi apparatus 0.0478978300180826 1623 25 6 0.24 0.00369685767097967
GO:CC GO:0030863 cortical cytoskeleton 0.0494830324860583 107 100 3 0.03 0.0280373831775701
GO:MF GO:0023026 MHC class II protein complex binding 8.02571581294609e-06 17 94 5 0.0531914893617021 0.294117647058824
GO:MF GO:0023023 MHC protein complex binding 3.33756286694675e-05 25 94 5 0.0531914893617021 0.2
GO:MF GO:0005501 retinoid binding 0.000197944804769894 37 12 3 0.25 0.0810810810810811
GO:MF GO:0019840 isoprenoid binding 0.000197944804769894 38 12 3 0.25 0.0789473684210526
GO:MF GO:0050431 transforming growth factor beta binding 0.00264908615273811 24 52 3 0.0576923076923077 0.125
GO:MF GO:0001540 amyloid-beta binding 0.0035163445564427 83 53 4 0.0754716981132075 0.0481927710843374
GO:MF GO:0019955 cytokine binding 0.0035163445564427 138 96 6 0.0625 0.0434782608695652
GO:MF GO:0008289 lipid binding 0.00355916454284176 776 57 10 0.175438596491228 0.0128865979381443
GO:MF GO:0019842 vitamin binding 0.00355916454284176 149 12 3 0.25 0.0201342281879195
GO:MF GO:0005044 scavenger receptor activity 0.00761657494515009 48 53 3 0.0566037735849057 0.0625
GO:MF GO:0019838 growth factor binding 0.00761657494515009 138 18 3 0.166666666666667 0.0217391304347826
GO:MF GO:0042277 peptide binding 0.00997909482399282 314 84 7 0.0833333333333333 0.0222929936305732
GO:MF GO:0005215 transporter activity 0.0139513576545053 1185 4 3 0.75 0.00253164556962025
GO:MF GO:0033218 amide binding 0.0180805150880962 389 25 4 0.16 0.0102827763496144
GO:MF GO:0140375 immune receptor activity 0.0197507266677745 133 75 4 0.0533333333333333 0.0300751879699248
GO:MF GO:0005543 phospholipid binding 0.0227232579594527 454 57 6 0.105263157894737 0.013215859030837
GO:MF GO:0044877 protein-containing complex binding 0.0230373811711581 1287 53 10 0.188679245283019 0.00777000777000777
GO:MF GO:0005515 protein binding 0.0230373811711581 14767 80 73 0.9125 0.00494345500101578
GO:MF GO:0005102 signaling receptor binding 0.0233599184547639 1672 23 7 0.304347826086957 0.0041866028708134
GO:MF GO:0042802 identical protein binding 0.0247448863069924 2067 7 4 0.571428571428571 0.0019351717464925
GO:MF GO:0048306 calcium-dependent protein binding 0.0306899146399309 82 84 3 0.0357142857142857 0.0365853658536585
GO:MF GO:0030165 PDZ domain binding 0.0317209816144558 89 79 3 0.0379746835443038 0.0337078651685393
GO:MF GO:0019887 protein kinase regulator activity 0.0386129271001604 191 79 4 0.0506329113924051 0.0209424083769634
GO:MF GO:0060089 molecular transducer activity 0.0433342666875595 1458 18 5 0.277777777777778 0.00342935528120713
GO:MF GO:0038023 signaling receptor activity 0.0433342666875595 1458 18 5 0.277777777777778 0.00342935528120713
GO:MF GO:0019899 enzyme binding 0.0433342666875595 2074 52 12 0.230769230769231 0.00578592092574735
KEGG KEGG:04940 Type I diabetes mellitus 0.0130026373782218 40 94 5 0.0531914893617021 0.125
KEGG KEGG:05310 Asthma 0.0173346573516681 27 94 4 0.0425531914893617 0.148148148148148
KEGG KEGG:05330 Allograft rejection 0.0215086033113903 34 94 4 0.0425531914893617 0.117647058823529
KEGG KEGG:05332 Graft-versus-host disease 0.0238545515801565 37 94 4 0.0425531914893617 0.108108108108108
KEGG KEGG:04659 Th17 cell differentiation 0.0261913335728628 104 94 6 0.0638297872340425 0.0576923076923077
KEGG KEGG:04612 Antigen processing and presentation 0.0261913335728628 69 54 4 0.0740740740740741 0.0579710144927536
KEGG KEGG:04672 Intestinal immune network for IgA production 0.0313109277659166 45 94 4 0.0425531914893617 0.0888888888888889
KEGG KEGG:05320 Autoimmune thyroid disease 0.0381890981511772 49 94 4 0.0425531914893617 0.0816326530612245
KEGG KEGG:04145 Phagosome 0.0407853834706177 147 54 5 0.0925925925925926 0.0340136054421769
KEGG KEGG:04640 Hematopoietic cell lineage 0.0463343334655574 95 54 4 0.0740740740740741 0.0421052631578947
KEGG KEGG:05416 Viral myocarditis 0.0466473058026678 56 94 4 0.0425531914893617 0.0714285714285714

pS19 transcription factor target enrichment of top program genes

TF enrichment of pS19
TFs corrosponding to activation of pS19. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.