pP11 program activity among Plasma cells

Activation of pP11
pP11 gene program activation in Plasma cells.
Gene program activation of pP11 by different cell subtypes
pP11 gene program activation among cells of different subtypes (Plasma cells).

pP11 top program genes

Top genes of pP11 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pP11 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pP11
pP11 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
CORUM CORUM:178 Respiratory chain complex I (holoenzyme), mitochondrial 8.8964168320516e-05 44 93 9 0.0967741935483871 0.204545454545455
CORUM CORUM:2914 Respiratory chain complex I (beta subunit) mitochondrial 0.00140801234522495 16 93 5 0.0537634408602151 0.3125
GO:BP GO:0022900 electron transport chain 2.57908179407903e-12 180 93 16 0.172043010752688 0.0888888888888889
GO:BP GO:0006120 mitochondrial electron transport, NADH to ubiquinone 3.13200016476847e-12 56 93 11 0.118279569892473 0.196428571428571
GO:BP GO:0042773 ATP synthesis coupled electron transport 3.13200016476847e-12 100 93 13 0.139784946236559 0.13
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 3.13200016476847e-12 99 93 13 0.139784946236559 0.131313131313131
GO:BP GO:0022904 respiratory electron transport chain 1.65858071863079e-11 117 93 13 0.139784946236559 0.111111111111111
GO:BP GO:0006119 oxidative phosphorylation 1.70670378597217e-11 151 93 14 0.150537634408602 0.0927152317880795
GO:BP GO:0045333 cellular respiration 7.17231061399271e-09 192 93 13 0.139784946236559 0.0677083333333333
GO:BP GO:0010257 NADH dehydrogenase complex assembly 1.77847577137459e-08 67 93 9 0.0967741935483871 0.134328358208955
GO:BP GO:0032981 mitochondrial respiratory chain complex I assembly 1.77847577137459e-08 67 93 9 0.0967741935483871 0.134328358208955
GO:BP GO:0046034 ATP metabolic process 1.81852876250017e-08 314 93 15 0.161290322580645 0.0477707006369427
GO:BP GO:0006091 generation of precursor metabolites and energy 4.70932810959878e-07 538 93 17 0.182795698924731 0.0315985130111524
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 6.2160368440914e-07 289 93 13 0.139784946236559 0.0449826989619377
GO:BP GO:0033108 mitochondrial respiratory chain complex assembly 6.2160368440914e-07 103 93 9 0.0967741935483871 0.087378640776699
GO:BP GO:0055114 obsolete oxidation-reduction process 7.22483278905077e-06 745 103 19 0.184466019417476 0.025503355704698
GO:BP GO:0050871 positive regulation of B cell activation 1.31337370660429e-05 151 6 4 0.666666666666667 0.0264900662251656
GO:BP GO:0050864 regulation of B cell activation 3.37190662913005e-05 194 6 4 0.666666666666667 0.0206185567010309
GO:BP GO:0007005 mitochondrion organization 0.000167471539736411 561 93 14 0.150537634408602 0.0249554367201426
GO:BP GO:0030449 regulation of complement activation 0.000179804773075944 110 31 5 0.161290322580645 0.0454545454545455
GO:BP GO:0042113 B cell activation 0.000237905578987279 330 6 4 0.666666666666667 0.0121212121212121
GO:BP GO:0051251 positive regulation of lymphocyte activation 0.00033778760115098 365 6 4 0.666666666666667 0.010958904109589
GO:BP GO:0002920 regulation of humoral immune response 0.000370723826911661 133 31 5 0.161290322580645 0.037593984962406
GO:BP GO:0006910 phagocytosis, recognition 0.000370723826911661 98 6 3 0.5 0.0306122448979592
GO:BP GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 0.000370723826911661 135 31 5 0.161290322580645 0.037037037037037
GO:BP GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 0.000370723826911661 135 31 5 0.161290322580645 0.037037037037037
GO:BP GO:0038094 Fc-gamma receptor signaling pathway 0.000382555660236357 137 31 5 0.161290322580645 0.0364963503649635
GO:BP GO:0002431 Fc receptor mediated stimulatory signaling pathway 0.000407242250082653 141 31 5 0.161290322580645 0.0354609929078014
GO:BP GO:0006958 complement activation, classical pathway 0.000407242250082653 142 31 5 0.161290322580645 0.0352112676056338
GO:BP GO:0002696 positive regulation of leukocyte activation 0.000407242250082653 412 6 4 0.666666666666667 0.00970873786407767
GO:BP GO:0050867 positive regulation of cell activation 0.000422927126081477 424 6 4 0.666666666666667 0.00943396226415094
GO:BP GO:0002697 regulation of immune effector process 0.000570075196993565 461 6 4 0.666666666666667 0.00867678958785249
GO:BP GO:0002455 humoral immune response mediated by circulating immunoglobulin 0.000582560858827606 156 31 5 0.161290322580645 0.032051282051282
GO:BP GO:0006911 phagocytosis, engulfment 0.000594023323897947 127 6 3 0.5 0.0236220472440945
GO:BP GO:0050853 B cell receptor signaling pathway 0.000686878590976101 135 6 3 0.5 0.0222222222222222
GO:BP GO:0099024 plasma membrane invagination 0.000686878590976101 136 6 3 0.5 0.0220588235294118
GO:BP GO:1903069 regulation of ER-associated ubiquitin-dependent protein catabolic process 0.000710719254763076 10 77 3 0.038961038961039 0.3
GO:BP GO:0051249 regulation of lymphocyte activation 0.000749433084846653 518 6 4 0.666666666666667 0.00772200772200772
GO:BP GO:0010324 membrane invagination 0.000749433084846653 144 6 3 0.5 0.0208333333333333
GO:BP GO:0006956 complement activation 0.000928233297655374 180 31 5 0.161290322580645 0.0277777777777778
GO:BP GO:0002694 regulation of leukocyte activation 0.00129732330598383 610 6 4 0.666666666666667 0.00655737704918033
GO:BP GO:0002252 immune effector process 0.00148678275462793 1309 140 25 0.178571428571429 0.0190985485103132
GO:BP GO:0044764 multi-organism cellular process 0.00148678275462793 17 59 3 0.0508474576271186 0.176470588235294
GO:BP GO:0050865 regulation of cell activation 0.00159884618015841 655 6 4 0.666666666666667 0.00610687022900763
GO:BP GO:0002443 leukocyte mediated immunity 0.00173737768719628 877 80 14 0.175 0.015963511972634
GO:BP GO:1903034 regulation of response to wounding 0.00173737768719628 169 64 6 0.09375 0.0355029585798817
GO:BP GO:0016310 phosphorylation 0.00190023926798509 2138 96 26 0.270833333333333 0.0121608980355472
GO:BP GO:0016064 immunoglobulin mediated immune response 0.00195073688725818 223 31 5 0.161290322580645 0.0224215246636771
GO:BP GO:0030433 ubiquitin-dependent ERAD pathway 0.00195073688725818 82 82 5 0.0609756097560976 0.0609756097560976
GO:BP GO:0019724 B cell mediated immunity 0.00201724235786438 226 6 3 0.5 0.0132743362831858
GO:BP GO:0009617 response to bacterium 0.00209346638314878 743 6 4 0.666666666666667 0.0053835800807537
GO:BP GO:0008037 cell recognition 0.00214514705628213 235 6 3 0.5 0.0127659574468085
GO:BP GO:0050778 positive regulation of immune response 0.00214514705628213 753 6 4 0.666666666666667 0.00531208499335989
GO:BP GO:0006909 phagocytosis 0.00215105522780648 387 31 6 0.193548387096774 0.0155038759689922
GO:BP GO:0038093 Fc receptor signaling pathway 0.00215105522780648 238 6 3 0.5 0.0126050420168067
GO:BP GO:0046649 lymphocyte activation 0.00221660473349302 771 6 4 0.666666666666667 0.00518806744487678
GO:BP GO:1904292 regulation of ERAD pathway 0.0037049826800935 20 77 3 0.038961038961039 0.15
GO:BP GO:0061041 regulation of wound healing 0.0037049826800935 136 59 5 0.0847457627118644 0.0367647058823529
GO:BP GO:0002679 respiratory burst involved in defense response 0.00378456404545635 13 123 3 0.024390243902439 0.230769230769231
GO:BP GO:0045730 respiratory burst 0.00397272647330756 35 123 4 0.032520325203252 0.114285714285714
GO:BP GO:0051707 response to other organism 0.00405069823797311 1592 7 5 0.714285714285714 0.00314070351758794
GO:BP GO:0043207 response to external biotic stimulus 0.00405069823797311 1594 7 5 0.714285714285714 0.00313676286072773
GO:BP GO:0036503 ERAD pathway 0.00433104799964489 103 82 5 0.0609756097560976 0.0485436893203883
GO:BP GO:0009607 response to biotic stimulus 0.00433104799964489 1626 7 5 0.714285714285714 0.0030750307503075
GO:BP GO:0050851 antigen receptor-mediated signaling pathway 0.00442258382772313 323 6 3 0.5 0.00928792569659443
GO:BP GO:0045321 leukocyte activation 0.00445349430472247 1332 84 17 0.202380952380952 0.0127627627627628
GO:BP GO:0050776 regulation of immune response 0.00496395759285807 996 6 4 0.666666666666667 0.00401606425702811
GO:BP GO:0042742 defense response to bacterium 0.00526372945738432 349 6 3 0.5 0.00859598853868195
GO:BP GO:1903036 positive regulation of response to wounding 0.00526372945738432 74 64 4 0.0625 0.0540540540540541
GO:BP GO:0002449 lymphocyte mediated immunity 0.00541723102576824 354 6 3 0.5 0.00847457627118644
GO:BP GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 0.00575883998389413 363 6 3 0.5 0.00826446280991736
GO:BP GO:0002684 positive regulation of immune system process 0.00603161638903793 1065 6 4 0.666666666666667 0.00375586854460094
GO:BP GO:0002407 dendritic cell chemotaxis 0.00658742486314146 24 84 3 0.0357142857142857 0.125
GO:BP GO:0006959 humoral immune response 0.00658742486314146 384 6 3 0.5 0.0078125
GO:BP GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process 0.00900642353033484 134 77 5 0.0649350649350649 0.0373134328358209
GO:BP GO:0006487 protein N-linked glycosylation 0.00900642353033484 76 136 5 0.0367647058823529 0.0657894736842105
GO:BP GO:0043312 neutrophil degranulation 0.00900642353033484 482 135 12 0.0888888888888889 0.024896265560166
GO:BP GO:0002283 neutrophil activation involved in immune response 0.00928193198707055 485 135 12 0.0888888888888889 0.0247422680412371
GO:BP GO:0090316 positive regulation of intracellular protein transport 0.00957430997462582 186 57 5 0.087719298245614 0.0268817204301075
GO:BP GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 0.0100545887077109 88 67 4 0.0597014925373134 0.0454545454545455
GO:BP GO:0036336 dendritic cell migration 0.0101530203600341 29 84 3 0.0357142857142857 0.103448275862069
GO:BP GO:0031647 regulation of protein stability 0.0102374618694186 300 9 3 0.333333333333333 0.01
GO:BP GO:0042119 neutrophil activation 0.0102374618694186 498 135 12 0.0888888888888889 0.0240963855421687
GO:BP GO:1990748 cellular detoxification 0.0102374618694186 113 54 4 0.0740740740740741 0.0353982300884956
GO:BP GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 0.0102374618694186 90 67 4 0.0597014925373134 0.0444444444444444
GO:BP GO:0001959 regulation of cytokine-mediated signaling pathway 0.0102374618694186 184 59 5 0.0847457627118644 0.0271739130434783
GO:BP GO:0002429 immune response-activating cell surface receptor signaling pathway 0.0102374618694186 477 6 3 0.5 0.00628930817610063
GO:BP GO:0002446 neutrophil mediated immunity 0.0102374618694186 497 135 12 0.0888888888888889 0.0241448692152917
GO:BP GO:0002757 immune response-activating signal transduction 0.0102374618694186 477 6 3 0.5 0.00628930817610063
GO:BP GO:0061024 membrane organization 0.0102374618694186 973 19 6 0.315789473684211 0.00616649537512847
GO:BP GO:0008219 cell death 0.0107904689986758 2292 66 19 0.287878787878788 0.00828970331588133
GO:BP GO:0036230 granulocyte activation 0.0110680786605418 504 135 12 0.0888888888888889 0.0238095238095238
GO:BP GO:0002768 immune response-regulating cell surface receptor signaling pathway 0.0113976763482991 512 6 3 0.5 0.005859375
GO:BP GO:0002764 immune response-regulating signaling pathway 0.0114079319362122 515 6 3 0.5 0.0058252427184466
GO:BP GO:0060759 regulation of response to cytokine stimulus 0.0114079319362122 197 59 5 0.0847457627118644 0.0253807106598985
GO:BP GO:0001775 cell activation 0.0114079319362122 1495 84 17 0.202380952380952 0.011371237458194
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.0114079319362122 3087 96 30 0.3125 0.00971817298347911
GO:BP GO:0097237 cellular response to toxic substance 0.0114079319362122 120 54 4 0.0740740740740741 0.0333333333333333
GO:BP GO:0012501 programmed cell death 0.0121996876395589 2143 66 18 0.272727272727273 0.00839944003733084
GO:BP GO:0044419 biological process involved in interspecies interaction between organisms 0.0125345205489196 2255 7 5 0.714285714285714 0.00221729490022173
GO:BP GO:0006793 phosphorus metabolic process 0.0128165040709198 3114 71 24 0.338028169014085 0.00770712909441233
GO:BP GO:0002253 activation of immune response 0.0137715193032403 568 6 3 0.5 0.00528169014084507
GO:BP GO:0019725 cellular homeostasis 0.0140658904923675 981 64 11 0.171875 0.0112130479102956
GO:BP GO:0006915 apoptotic process 0.0141987897088124 1990 66 17 0.257575757575758 0.0085427135678392
GO:BP GO:0048584 positive regulation of response to stimulus 0.0142106047076148 2344 7 5 0.714285714285714 0.00213310580204778
GO:BP GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process 0.0149611018616832 107 67 4 0.0597014925373134 0.0373831775700935
GO:BP GO:0043299 leukocyte degranulation 0.0149650224523306 535 135 12 0.0888888888888889 0.0224299065420561
GO:BP GO:0032388 positive regulation of intracellular transport 0.0149966935259567 229 32 4 0.125 0.0174672489082969
GO:BP GO:0098754 detoxification 0.0149966935259567 134 54 4 0.0740740740740741 0.0298507462686567
GO:BP GO:2000058 regulation of ubiquitin-dependent protein catabolic process 0.0150181623155044 165 77 5 0.0649350649350649 0.0303030303030303
GO:BP GO:0097190 apoptotic signaling pathway 0.0150181623155044 600 59 8 0.135593220338983 0.0133333333333333
GO:BP GO:0090303 positive regulation of wound healing 0.016385569044724 60 54 3 0.0555555555555556 0.05
GO:BP GO:1901800 positive regulation of proteasomal protein catabolic process 0.0168309116133641 112 67 4 0.0597014925373134 0.0357142857142857
GO:BP GO:0002275 myeloid cell activation involved in immune response 0.0171023765153472 547 135 12 0.0888888888888889 0.0219378427787934
GO:BP GO:0002682 regulation of immune system process 0.0171410647076109 1617 6 4 0.666666666666667 0.00247371675943105
GO:BP GO:0009896 positive regulation of catabolic process 0.0176543354789911 464 8 3 0.375 0.00646551724137931
GO:BP GO:0002444 myeloid leukocyte mediated immunity 0.017810015366997 551 135 12 0.0888888888888889 0.0217785843920145
GO:BP GO:0033157 regulation of intracellular protein transport 0.0183748371119084 264 77 6 0.0779220779220779 0.0227272727272727
GO:BP GO:0071345 cellular response to cytokine stimulus 0.0184391258947826 1132 4 3 0.75 0.00265017667844523
GO:BP GO:0002366 leukocyte activation involved in immune response 0.0184391258947826 717 135 14 0.103703703703704 0.0195258019525802
GO:BP GO:0002263 cell activation involved in immune response 0.0188116780133055 721 135 14 0.103703703703704 0.0194174757281553
GO:BP GO:0018279 protein N-linked glycosylation via asparagine 0.0188116780133055 30 120 3 0.025 0.1
GO:BP GO:0002250 adaptive immune response 0.0188116780133055 689 6 3 0.5 0.00435413642960813
GO:BP GO:0006897 endocytosis 0.0191575025451254 696 6 3 0.5 0.00431034482758621
GO:BP GO:0048878 chemical homeostasis 0.0199128439090372 1229 64 12 0.1875 0.00976403580146461
GO:BP GO:0018196 peptidyl-asparagine modification 0.0199498337895034 31 120 3 0.025 0.0967741935483871
GO:BP GO:2001233 regulation of apoptotic signaling pathway 0.0203751775414576 363 59 6 0.101694915254237 0.0165289256198347
GO:BP GO:0034097 response to cytokine 0.0206785089386244 1226 4 3 0.75 0.00244698205546493
GO:BP GO:0061136 regulation of proteasomal protein catabolic process 0.0206785089386244 186 77 5 0.0649350649350649 0.0268817204301075
GO:BP GO:0033344 cholesterol efflux 0.0221607723011007 66 59 3 0.0508474576271186 0.0454545454545455
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 0.0224381067798864 129 67 4 0.0597014925373134 0.0310077519379845
GO:BP GO:0030193 regulation of blood coagulation 0.0232715255433993 68 59 3 0.0508474576271186 0.0441176470588235
GO:BP GO:1903362 regulation of cellular protein catabolic process 0.0232715255433993 257 86 6 0.0697674418604651 0.0233463035019455
GO:BP GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process 0.0232715255433993 131 67 4 0.0597014925373134 0.0305343511450382
GO:BP GO:0030162 regulation of proteolysis 0.0232715255433993 752 78 10 0.128205128205128 0.0132978723404255
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 0.0235901854933287 132 67 4 0.0597014925373134 0.0303030303030303
GO:BP GO:0006383 transcription by RNA polymerase III 0.0237817037367305 48 85 3 0.0352941176470588 0.0625
GO:BP GO:1900046 regulation of hemostasis 0.0237817037367305 69 59 3 0.0508474576271186 0.0434782608695652
GO:BP GO:2001236 regulation of extrinsic apoptotic signaling pathway 0.0237817037367305 159 140 6 0.0428571428571429 0.0377358490566038
GO:BP GO:0048145 regulation of fibroblast proliferation 0.0248126592991004 87 48 3 0.0625 0.0344827586206897
GO:BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 0.0250455507902649 136 67 4 0.0597014925373134 0.0294117647058824
GO:BP GO:0048144 fibroblast proliferation 0.0252273106224078 88 48 3 0.0625 0.0340909090909091
GO:BP GO:0009605 response to external stimulus 0.0270970126671973 2944 7 5 0.714285714285714 0.00169836956521739
GO:BP GO:0045732 positive regulation of protein catabolic process 0.0278439661954812 237 67 5 0.0746268656716418 0.0210970464135021
GO:BP GO:0050818 regulation of coagulation 0.0280304536209854 75 59 3 0.0508474576271186 0.04
GO:BP GO:1904951 positive regulation of establishment of protein localization 0.0285017774981913 345 69 6 0.0869565217391304 0.0173913043478261
GO:BP GO:0048147 negative regulation of fibroblast proliferation 0.0291974437042975 34 136 3 0.0220588235294118 0.0882352941176471
GO:BP GO:0006040 amino sugar metabolic process 0.0299814924022288 42 112 3 0.0267857142857143 0.0714285714285714
GO:BP GO:0045055 regulated exocytosis 0.0299814924022288 785 135 14 0.103703703703704 0.0178343949044586
GO:BP GO:0001960 negative regulation of cytokine-mediated signaling pathway 0.0319360222626535 82 59 3 0.0508474576271186 0.0365853658536585
GO:BP GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 0.0327746081799893 221 77 5 0.0649350649350649 0.0226244343891403
GO:BP GO:1903364 positive regulation of cellular protein catabolic process 0.0329736642774117 154 67 4 0.0597014925373134 0.025974025974026
GO:BP GO:0051222 positive regulation of protein transport 0.0332198337696762 329 32 4 0.125 0.0121580547112462
GO:BP GO:0055082 cellular chemical homeostasis 0.0340149434022918 841 64 9 0.140625 0.0107015457788347
GO:BP GO:0045862 positive regulation of proteolysis 0.034408463504419 378 67 6 0.0895522388059701 0.0158730158730159
GO:BP GO:0000041 transition metal ion transport 0.034514261290211 129 135 5 0.037037037037037 0.0387596899224806
GO:BP GO:0042176 regulation of protein catabolic process 0.0358382635172338 401 86 7 0.0813953488372093 0.0174563591022444
GO:BP GO:0060761 negative regulation of response to cytokine stimulus 0.0358382635172338 88 59 3 0.0508474576271186 0.0340909090909091
GO:BP GO:0045087 innate immune response 0.0358382635172338 998 6 3 0.5 0.0030060120240481
GO:BP GO:0006826 iron ion transport 0.036144340207961 80 135 4 0.0296296296296296 0.05
GO:BP GO:0006955 immune response 0.036475708221407 2311 135 29 0.214814814814815 0.0125486802250108
GO:BP GO:0010941 regulation of cell death 0.0366558970627764 1720 66 14 0.212121212121212 0.00813953488372093
GO:BP GO:0032101 regulation of response to external stimulus 0.0370530769576663 1051 84 12 0.142857142857143 0.0114176974310181
GO:BP GO:0042592 homeostatic process 0.0370530769576663 1981 64 15 0.234375 0.00757193336698637
GO:BP GO:0060548 negative regulation of cell death 0.0370725163610056 1038 64 10 0.15625 0.00963391136801541
GO:BP GO:2001235 positive regulation of apoptotic signaling pathway 0.0370725163610056 129 140 5 0.0357142857142857 0.0387596899224806
GO:BP GO:0098869 cellular oxidant detoxification 0.0370725163610056 100 54 3 0.0555555555555556 0.03
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0395898879505443 810 24 5 0.208333333333333 0.00617283950617284
GO:BP GO:0032386 regulation of intracellular transport 0.040135864502397 367 32 4 0.125 0.0108991825613079
GO:BP GO:0120162 positive regulation of cold-induced thermogenesis 0.0409156367086982 97 59 3 0.0508474576271186 0.0309278350515464
GO:BP GO:0002274 myeloid leukocyte activation 0.0421926833521312 667 135 12 0.0888888888888889 0.0179910044977511
GO:BP GO:0043067 regulation of programmed cell death 0.0421926833521312 1582 66 13 0.196969696969697 0.00821744627054362
GO:BP GO:0009615 response to virus 0.0421926833521312 364 33 4 0.121212121212121 0.010989010989011
GO:BP GO:1905897 regulation of response to endoplasmic reticulum stress 0.0421926833521312 84 140 4 0.0285714285714286 0.0476190476190476
GO:BP GO:0055092 sterol homeostasis 0.0421926833521312 100 59 3 0.0508474576271186 0.03
GO:BP GO:0042632 cholesterol homeostasis 0.0421926833521312 99 59 3 0.0508474576271186 0.0303030303030303
GO:BP GO:0045454 cell redox homeostasis 0.0430232888017289 58 103 3 0.029126213592233 0.0517241379310345
GO:BP GO:0002532 production of molecular mediator involved in inflammatory response 0.0436030697629886 94 64 3 0.046875 0.0319148936170213
GO:BP GO:0043933 protein-containing complex subunit organization 0.0447550856219708 1963 93 19 0.204301075268817 0.00967906265919511
GO:BP GO:0043066 negative regulation of apoptotic process 0.0458623635890617 921 64 9 0.140625 0.00977198697068404
GO:BP GO:0044409 entry into host 0.0458623635890617 154 80 4 0.05 0.025974025974026
GO:BP GO:0065003 protein-containing complex assembly 0.0460558008950708 1680 93 17 0.182795698924731 0.0101190476190476
GO:BP GO:0006979 response to oxidative stress 0.0473103997384636 466 103 8 0.0776699029126214 0.0171673819742489
GO:BP GO:0098542 defense response to other organism 0.0476944390017553 1218 6 3 0.5 0.00246305418719212
GO:BP GO:2001238 positive regulation of extrinsic apoptotic signaling pathway 0.0482197399352134 48 134 3 0.0223880597014925 0.0625
GO:BP GO:1903573 negative regulation of response to endoplasmic reticulum stress 0.0482197399352134 46 140 3 0.0214285714285714 0.0652173913043478
GO:BP GO:0031668 cellular response to extracellular stimulus 0.0497413477659744 248 83 5 0.0602409638554217 0.0201612903225806
GO:BP GO:0043069 negative regulation of programmed cell death 0.0498064933527588 943 64 9 0.140625 0.0095440084835631
GO:CC GO:0070469 respirasome 1.1294043367694e-12 103 93 13 0.139784946236559 0.12621359223301
GO:CC GO:0005746 mitochondrial respirasome 1.08804750799117e-10 89 93 11 0.118279569892473 0.123595505617978
GO:CC GO:0005747 mitochondrial respiratory chain complex I 2.15325498246428e-10 51 93 9 0.0967741935483871 0.176470588235294
GO:CC GO:0045271 respiratory chain complex I 2.15325498246428e-10 51 93 9 0.0967741935483871 0.176470588235294
GO:CC GO:0030964 NADH dehydrogenase complex 2.15325498246428e-10 51 93 9 0.0967741935483871 0.176470588235294
GO:CC GO:0098800 inner mitochondrial membrane protein complex 4.24331223593943e-10 146 93 12 0.129032258064516 0.0821917808219178
GO:CC GO:0098803 respiratory chain complex 6.92926653238166e-10 86 93 10 0.10752688172043 0.116279069767442
GO:CC GO:1990204 oxidoreductase complex 1.22541731246872e-09 113 103 11 0.106796116504854 0.0973451327433628
GO:CC GO:0005743 mitochondrial inner membrane 2.22224910931282e-09 503 95 18 0.189473684210526 0.0357852882703777
GO:CC GO:0019866 organelle inner membrane 1.27696876917141e-08 564 95 18 0.189473684210526 0.0319148936170213
GO:CC GO:0031966 mitochondrial membrane 1.90585588666551e-08 746 104 21 0.201923076923077 0.0281501340482574
GO:CC GO:0098798 mitochondrial protein-containing complex 2.20709926525832e-08 270 93 13 0.139784946236559 0.0481481481481481
GO:CC GO:0005740 mitochondrial envelope 5.28295991517828e-08 797 104 21 0.201923076923077 0.0263488080301129
GO:CC GO:0005739 mitochondrion 2.93669220137055e-07 1673 97 28 0.288659793814433 0.0167364016736402
GO:CC GO:0031090 organelle membrane 1.39746888421845e-06 3612 140 54 0.385714285714286 0.0149501661129568
GO:CC GO:0031975 envelope 3.18841665292344e-06 1237 95 22 0.231578947368421 0.0177849636216653
GO:CC GO:0031967 organelle envelope 3.18841665292344e-06 1237 95 22 0.231578947368421 0.0177849636216653
GO:CC GO:0042571 immunoglobulin complex, circulating 2.68841662428241e-05 77 6 3 0.5 0.038961038961039
GO:CC GO:0005773 vacuole 9.4821911142348e-05 810 135 19 0.140740740740741 0.0234567901234568
GO:CC GO:0019814 immunoglobulin complex 0.000133556248048331 167 31 5 0.161290322580645 0.029940119760479
GO:CC GO:0072562 blood microparticle 0.000139941585580747 140 6 3 0.5 0.0214285714285714
GO:CC GO:0070062 extracellular exosome 0.000174751114311278 2176 82 24 0.292682926829268 0.0110294117647059
GO:CC GO:0005766 primary lysosome 0.000231029923231246 154 135 8 0.0592592592592593 0.051948051948052
GO:CC GO:0042582 azurophil granule 0.000231029923231246 154 135 8 0.0592592592592593 0.051948051948052
GO:CC GO:0043230 extracellular organelle 0.000286767063571186 2263 82 24 0.292682926829268 0.0106053910737958
GO:CC GO:1903561 extracellular vesicle 0.000286767063571186 2261 82 24 0.292682926829268 0.0106147722246793
GO:CC GO:0016020 membrane 0.000596038123739369 9838 140 96 0.685714285714286 0.00975808091075422
GO:CC GO:0000323 lytic vacuole 0.000596038123739369 712 135 16 0.118518518518519 0.0224719101123595
GO:CC GO:0005764 lysosome 0.000596038123739369 712 135 16 0.118518518518519 0.0224719101123595
GO:CC GO:0035578 azurophil granule lumen 0.000596038123739369 91 135 6 0.0444444444444444 0.0659340659340659
GO:CC GO:1902494 catalytic complex 0.000961952149030021 1441 103 20 0.194174757281553 0.0138792505204719
GO:CC GO:0098796 membrane protein complex 0.00185844972307777 1322 83 16 0.192771084337349 0.0121028744326778
GO:CC GO:0031300 intrinsic component of organelle membrane 0.00185844972307777 413 112 10 0.0892857142857143 0.0242130750605327
GO:CC GO:0009897 external side of plasma membrane 0.00193098402993405 408 6 3 0.5 0.00735294117647059
GO:CC GO:0005767 secondary lysosome 0.00193098402993405 16 135 3 0.0222222222222222 0.1875
GO:CC GO:0005783 endoplasmic reticulum 0.00241458331293561 1982 140 29 0.207142857142857 0.0146316851664985
GO:CC GO:0005775 vacuolar lumen 0.00243932539559835 174 135 7 0.0518518518518519 0.0402298850574713
GO:CC GO:0031224 intrinsic component of membrane 0.00258671158334884 5868 108 51 0.472222222222222 0.00869120654396728
GO:CC GO:0016021 integral component of membrane 0.00258671158334884 5711 108 50 0.462962962962963 0.00875503414463316
GO:CC GO:0005615 extracellular space 0.00300474452376226 3594 82 29 0.353658536585366 0.00806900389538119
GO:CC GO:0031227 intrinsic component of endoplasmic reticulum membrane 0.00300474452376226 166 106 6 0.0566037735849057 0.036144578313253
GO:CC GO:0005737 cytoplasm 0.00402251443142639 11911 126 97 0.76984126984127 0.00814373268407355
GO:CC GO:0034774 secretory granule lumen 0.00407009907035496 320 135 9 0.0666666666666667 0.028125
GO:CC GO:0060205 cytoplasmic vesicle lumen 0.0043539473411422 324 135 9 0.0666666666666667 0.0277777777777778
GO:CC GO:0031983 vesicle lumen 0.00445374619842401 326 135 9 0.0666666666666667 0.0276073619631902
GO:CC GO:0098552 side of membrane 0.00507987577584083 619 6 3 0.5 0.00484652665589661
GO:CC GO:0009986 cell surface 0.006896152168397 899 17 5 0.294117647058824 0.00556173526140156
GO:CC GO:0031301 integral component of organelle membrane 0.00792072667762207 382 102 8 0.0784313725490196 0.0209424083769634
GO:CC GO:0031982 vesicle 0.00833554110579703 4055 82 30 0.365853658536585 0.00739827373612824
GO:CC GO:0043227 membrane-bounded organelle 0.0100621069188846 12858 126 101 0.801587301587302 0.0078550318867631
GO:CC GO:0030176 integral component of endoplasmic reticulum membrane 0.0115150336846944 158 102 5 0.0490196078431373 0.0316455696202532
GO:CC GO:0012505 endomembrane system 0.0128618512026517 4640 140 50 0.357142857142857 0.0107758620689655
GO:CC GO:0031984 organelle subcompartment 0.0130331639195375 1773 137 24 0.175182481751825 0.0135363790186125
GO:CC GO:0030141 secretory granule 0.0193433011513139 851 135 14 0.103703703703704 0.0164512338425382
GO:CC GO:0005576 extracellular region 0.0229860665684325 4567 56 23 0.410714285714286 0.0050361287497263
GO:CC GO:0070820 tertiary granule 0.028482873920101 163 78 4 0.0512820512820513 0.0245398773006135
GO:CC GO:0005776 autophagosome 0.0318781332151241 98 135 4 0.0296296296296296 0.0408163265306122
GO:CC GO:0005789 endoplasmic reticulum membrane 0.0344602100935179 1117 123 15 0.121951219512195 0.0134288272157565
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0347836798318765 11296 112 80 0.714285714285714 0.00708215297450425
GO:CC GO:0098827 endoplasmic reticulum subcompartment 0.0347836798318765 1122 123 15 0.121951219512195 0.0133689839572193
GO:CC GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network 0.0384922799521658 1139 123 15 0.121951219512195 0.0131694468832309
GO:CC GO:0101002 ficolin-1-rich granule 0.0384922799521658 184 78 4 0.0512820512820513 0.0217391304347826
GO:CC GO:0005759 mitochondrial matrix 0.0395553177934489 479 89 7 0.0786516853932584 0.0146137787056367
GO:CC GO:0099503 secretory vesicle 0.0449714606523493 1020 140 15 0.107142857142857 0.0147058823529412
GO:MF GO:0009055 electron transfer activity 4.10263971171753e-09 148 93 12 0.129032258064516 0.0810810810810811
GO:MF GO:0003954 NADH dehydrogenase activity 3.01326557266887e-07 46 93 7 0.0752688172043011 0.152173913043478
GO:MF GO:0008137 NADH dehydrogenase (ubiquinone) activity 3.01326557266887e-07 46 93 7 0.0752688172043011 0.152173913043478
GO:MF GO:0050136 NADH dehydrogenase (quinone) activity 3.01326557266887e-07 46 93 7 0.0752688172043011 0.152173913043478
GO:MF GO:0003955 NAD(P)H dehydrogenase (quinone) activity 3.82217859567753e-07 49 93 7 0.0752688172043011 0.142857142857143
GO:MF GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 1.54119980709345e-06 61 93 7 0.0752688172043011 0.114754098360656
GO:MF GO:0016651 oxidoreductase activity, acting on NAD(P)H 8.42843200055265e-06 107 103 8 0.0776699029126214 0.0747663551401869
GO:MF GO:0016491 oxidoreductase activity 1.10401278062329e-05 771 103 18 0.174757281553398 0.0233463035019455
GO:MF GO:0034987 immunoglobulin receptor binding 7.00998316771496e-05 79 6 3 0.5 0.0379746835443038
GO:MF GO:0003823 antigen binding 0.000294314589774927 163 31 5 0.161290322580645 0.0306748466257669
GO:MF GO:0032934 sterol binding 0.0102264642020725 60 106 4 0.0377358490566038 0.0666666666666667
GO:MF GO:0004601 peroxidase activity 0.0118134499653497 53 54 3 0.0555555555555556 0.0566037735849057
GO:MF GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 0.0137697724978345 57 54 3 0.0555555555555556 0.0526315789473684
GO:MF GO:0008198 ferrous iron binding 0.0168898761846873 26 135 3 0.0222222222222222 0.115384615384615
GO:MF GO:0005102 signaling receptor binding 0.0168898761846873 1672 6 4 0.666666666666667 0.00239234449760766
GO:MF GO:0004869 cysteine-type endopeptidase inhibitor activity 0.0213939427730924 52 78 3 0.0384615384615385 0.0576923076923077
GO:MF GO:0016209 antioxidant activity 0.0254733106672568 87 54 3 0.0555555555555556 0.0344827586206897
GO:MF GO:0005496 steroid binding 0.0270286480781038 100 106 4 0.0377358490566038 0.04
GO:MF GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 0.0270286480781038 38 134 3 0.0223880597014925 0.0789473684210526
GO:MF GO:0015485 cholesterol binding 0.0298594610517934 50 106 3 0.0283018867924528 0.06
GO:MF GO:0051536 iron-sulfur cluster binding 0.0402698434535775 70 87 3 0.0344827586206897 0.0428571428571429
GO:MF GO:0051540 metal cluster binding 0.0402698434535775 70 87 3 0.0344827586206897 0.0428571428571429
GO:MF GO:0019901 protein kinase binding 0.043982572510103 673 59 7 0.11864406779661 0.0104011887072808
GO:MF GO:0019900 kinase binding 0.0441854645640512 752 96 10 0.104166666666667 0.0132978723404255
KEGG KEGG:04932 Non-alcoholic fatty liver disease 2.23002028649881e-07 150 93 14 0.150537634408602 0.0933333333333333
KEGG KEGG:00190 Oxidative phosphorylation 1.83907511997201e-06 133 109 13 0.119266055045872 0.0977443609022556
KEGG KEGG:04714 Thermogenesis 1.93322879891432e-05 232 93 14 0.150537634408602 0.0603448275862069
KEGG KEGG:05415 Diabetic cardiomyopathy 6.58441594663412e-05 203 103 13 0.12621359223301 0.0640394088669951
KEGG KEGG:05012 Parkinson disease 0.000151627817485038 249 79 12 0.151898734177215 0.0481927710843374
KEGG KEGG:04723 Retrograde endocannabinoid signaling 0.000186783202341015 148 93 10 0.10752688172043 0.0675675675675676
KEGG KEGG:05020 Prion disease 0.000199496796828369 273 103 14 0.135922330097087 0.0512820512820513
KEGG KEGG:05016 Huntington disease 0.000754112064173294 306 79 12 0.151898734177215 0.0392156862745098
KEGG KEGG:05014 Amyotrophic lateral sclerosis 0.000799238075189995 363 79 13 0.164556962025316 0.0358126721763085
KEGG KEGG:05010 Alzheimer disease 0.003595733740519 369 79 12 0.151898734177215 0.032520325203252
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 0.0303445040537227 475 79 12 0.151898734177215 0.0252631578947368
MIRNA MIRNA:hsa-miR-4763-3p hsa-miR-4763-3p 0.0360797078105338 282 36 6 0.166666666666667 0.0212765957446809
MIRNA MIRNA:hsa-miR-1207-5p hsa-miR-1207-5p 0.0360797078105338 287 36 6 0.166666666666667 0.0209059233449477
REAC REAC:R-HSA-611105 Respiratory electron transport 2.79225632309801e-08 100 93 12 0.129032258064516 0.12
REAC REAC:R-HSA-6799198 Complex I biogenesis 1.54957575719896e-07 55 93 9 0.0967741935483871 0.163636363636364
REAC REAC:R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 1.54957575719896e-07 124 93 12 0.129032258064516 0.0967741935483871
REAC REAC:R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport 4.26668731511239e-06 174 93 12 0.129032258064516 0.0689655172413793
REAC REAC:R-HSA-173623 Classical antibody-mediated complement activation 7.77389313188802e-05 61 31 5 0.161290322580645 0.0819672131147541
REAC REAC:R-HSA-2029481 FCGR activation 9.59026718543789e-05 67 31 5 0.161290322580645 0.0746268656716418
REAC REAC:R-HSA-166786 Creation of C4 and C2 activators 9.59026718543789e-05 68 31 5 0.161290322580645 0.0735294117647059
REAC REAC:R-HSA-166663 Initial triggering of complement 0.000146291397982498 76 31 5 0.161290322580645 0.0657894736842105
REAC REAC:R-HSA-2029485 Role of phospholipids in phagocytosis 0.000178490705990469 81 31 5 0.161290322580645 0.0617283950617284
REAC REAC:R-HSA-9664323 FCGR3A-mediated IL10 synthesis 0.000317885575757101 93 31 5 0.161290322580645 0.0537634408602151
REAC REAC:R-HSA-977606 Regulation of Complement cascade 0.000433234882591754 101 31 5 0.161290322580645 0.0495049504950495
REAC REAC:R-HSA-9664417 Leishmania phagocytosis 0.000549237840685757 113 31 5 0.161290322580645 0.0442477876106195
REAC REAC:R-HSA-9664407 Parasite infection 0.000549237840685757 113 31 5 0.161290322580645 0.0442477876106195
REAC REAC:R-HSA-9664422 FCGR3A-mediated phagocytosis 0.000549237840685757 113 31 5 0.161290322580645 0.0442477876106195
REAC REAC:R-HSA-166658 Complement cascade 0.000549237840685757 111 31 5 0.161290322580645 0.045045045045045
REAC REAC:R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 0.000584739878301132 116 31 5 0.161290322580645 0.0431034482758621
REAC REAC:R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis 0.00122552929830946 140 6 3 0.5 0.0214285714285714
REAC REAC:R-HSA-9662851 Anti-inflammatory response favouring Leishmania parasite infection 0.00427231401780351 221 6 3 0.5 0.0135746606334842
REAC REAC:R-HSA-9664433 Leishmania parasite growth and survival 0.00427231401780351 221 6 3 0.5 0.0135746606334842
REAC REAC:R-HSA-3299685 Detoxification of Reactive Oxygen Species 0.00758204353157462 35 103 4 0.0388349514563107 0.114285714285714
REAC REAC:R-HSA-9711123 Cellular response to chemical stress 0.00758204353157462 35 103 4 0.0388349514563107 0.114285714285714
REAC REAC:R-HSA-9658195 Leishmania infection 0.00896850735181939 303 6 3 0.5 0.0099009900990099
TF TF:M10435_1 Factor: Sp2; motif: GGGGCGGGG; match class: 1 0.00878435847323308 3495 125 43 0.344 0.0123032904148784
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.00878435847323308 3020 125 40 0.32 0.0132450331125828
TF TF:M07063_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.00878435847323308 3495 125 43 0.344 0.0123032904148784
TF TF:M08205_1 Factor: E2F-1:Elk-1; motif: SGCGCSNNAMCGGAAGT; match class: 1 0.00878435847323308 10438 126 92 0.73015873015873 0.00881394903238168
TF TF:M03913_1 Factor: KLF14; motif: NRCCACGCCCMCYN; match class: 1 0.008988417810869 64 12 3 0.25 0.046875
TF TF:M03807_1 Factor: SP2; motif: GNNGGGGGCGGGGSN; match class: 1 0.00973877563221033 4199 125 48 0.384 0.0114312931650393
TF TF:M10530_1 Factor: sp4; motif: NNNGCYCCGCCCCCY; match class: 1 0.00973877563221033 3780 138 48 0.347826086956522 0.0126984126984127
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.0109295393011681 6334 125 63 0.504 0.00994632143984844
TF TF:M00932_1 Factor: Sp1; motif: NNGGGGCGGGGNN; match class: 1 0.0109295393011681 6047 125 61 0.488 0.0100876467669919
TF TF:M00196_1 Factor: Sp1; motif: NGGGGGCGGGGYN; match class: 1 0.0109295393011681 5919 125 60 0.48 0.010136847440446
TF TF:M03920 Factor: SP1; motif: RCCMCRCCCMC 0.0118734780452907 7283 138 75 0.543478260869565 0.0102979541397776
TF TF:M00933_1 Factor: Sp1; motif: CCCCGCCCCN; match class: 1 0.0118734780452907 5166 139 59 0.424460431654676 0.0114208284939992
TF TF:M12173_1 Factor: GKLF; motif: NNCCMCRCCCN; match class: 1 0.013154512257189 4965 139 57 0.410071942446043 0.0114803625377644
TF TF:M12186_1 Factor: BTEB4; motif: NCCACGCCCM; match class: 1 0.013154512257189 3958 130 46 0.353846153846154 0.011622031328954
TF TF:M07277_1 Factor: BTEB2; motif: RGGGNGKGGN; match class: 1 0.013154512257189 4149 138 50 0.36231884057971 0.0120510966497951
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.013154512257189 3614 125 42 0.336 0.0116214720531267
TF TF:M00716_1 Factor: ZF5; motif: GSGCGCGR; match class: 1 0.0140740969017658 14106 137 118 0.861313868613139 0.00836523465192117
TF TF:M00803 Factor: E2F; motif: GGCGSG 0.0140740969017658 13190 140 115 0.821428571428571 0.00871872630780895
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.0177318832133775 7469 125 69 0.552 0.00923818449591646
TF TF:M12156_1 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN; match class: 1 0.0177318832133775 1002 125 18 0.144 0.0179640718562874
TF TF:M00244_1 Factor: NGFI-C; motif: WTGCGTGGGYGG; match class: 1 0.0177318832133775 1772 135 27 0.2 0.0152370203160271
TF TF:M00803_1 Factor: E2F; motif: GGCGSG; match class: 1 0.0177318832133775 10230 139 95 0.683453237410072 0.00928641251221896
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0202270952804606 6225 125 60 0.48 0.00963855421686747
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0202270952804606 7696 140 77 0.55 0.0100051975051975
TF TF:M08377_1 Factor: meis1:Elf-1; motif: NTGCCGGAAGTN; match class: 1 0.0202270952804606 5051 129 53 0.410852713178295 0.0104929716887745
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0202270952804606 5905 125 58 0.464 0.00982218458933107
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0202270952804606 7696 140 77 0.55 0.0100051975051975
TF TF:M11531_1 Factor: E2F-2; motif: GCGCGCGCGYW; match class: 1 0.0202270952804606 12351 126 99 0.785714285714286 0.00801554529997571
TF TF:M11821_1 Factor: T3R-beta; motif: NTGACCTNACGTGACCTYA; match class: 1 0.02181991967259 211 134 8 0.0597014925373134 0.037914691943128
TF TF:M12186 Factor: BTEB4; motif: NCCACGCCCM 0.0220543504842967 9135 125 79 0.632 0.00864805692391899
TF TF:M03922 Factor: SP4; motif: NWRGCCACGCCCMCTYN 0.0250727179978204 6046 140 64 0.457142857142857 0.0105855110817069
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.0273502466827163 3783 123 41 0.333333333333333 0.0108379592915675
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.0286992700939165 10494 140 96 0.685714285714286 0.00914808461978273
TF TF:M04826_1 Factor: p300; motif: ACNTCCG; match class: 1 0.0289054621481084 15260 136 122 0.897058823529412 0.00799475753604194
TF TF:M12151_1 Factor: Sp1; motif: NWRGCCMCGCCCMCN; match class: 1 0.0294380488316607 2548 123 31 0.252032520325203 0.0121664050235479
TF TF:M02089_1 Factor: E2F-3; motif: GGCGGGN; match class: 1 0.0296659652818211 9362 140 88 0.628571428571429 0.00939970091860714
TF TF:M12157_1 Factor: KLF15; motif: RCCACGCCCCCC; match class: 1 0.0296659652818211 816 123 15 0.121951219512195 0.0183823529411765
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0315410597403698 8415 140 81 0.578571428571429 0.00962566844919786
TF TF:M11765 Factor: TR2; motif: NRGGTCRYGACCYN 0.0315410597403698 3058 65 22 0.338461538461538 0.00719424460431655
TF TF:M11052 Factor: Hey2; motif: NNCACGYGNN 0.0315410597403698 12502 139 108 0.776978417266187 0.00863861782114862
TF TF:M03582_1 Factor: TWIST; motif: CACCTGG; match class: 1 0.0315410597403698 2579 112 29 0.258928571428571 0.0112446684761535
TF TF:M00933 Factor: Sp1; motif: CCCCGCCCCN 0.0327440179360369 9715 140 90 0.642857142857143 0.00926402470406588
TF TF:M05332 Factor: Sp2; motif: WGGGCGG 0.0327440179360369 8578 140 82 0.585714285714286 0.00955933784098858
TF TF:M05444 Factor: CPBP; motif: NGGGCGG 0.0327440179360369 8578 140 82 0.585714285714286 0.00955933784098858
TF TF:M05361 Factor: Sp6; motif: WGGGCGG 0.0327440179360369 8578 140 82 0.585714285714286 0.00955933784098858
TF TF:M01200_1 Factor: CTCF; motif: NNNGCCASCAGRKGGCRSNN; match class: 1 0.0334804978341912 554 21 5 0.238095238095238 0.00902527075812274
TF TF:M09765_1 Factor: SP1; motif: NRGKGGGCGGGGCN; match class: 1 0.0345508415935135 3318 138 40 0.289855072463768 0.0120554550934298
TF TF:M04710 Factor: CHD2; motif: TCTCGCGAG 0.035535506327139 14109 136 115 0.845588235294118 0.00815082571408321
TF TF:M03922_1 Factor: SP4; motif: NWRGCCACGCCCMCTYN; match class: 1 0.035535506327139 2143 123 27 0.219512195121951 0.0125991600559963
TF TF:M04012 Factor: HSFY1; motif: TTTCGAACG 0.0360611758175871 1013 128 17 0.1328125 0.016781836130306
TF TF:M04869_1 Factor: Egr-1; motif: GCGCATGCG; match class: 1 0.0360611758175871 10253 136 91 0.669117647058823 0.00887545108748659
TF TF:M09969 Factor: EKLF; motif: NGGGYGKGGCNNGG 0.0360611758175871 4589 123 46 0.373983739837398 0.0100239703639137
TF TF:M11603_1 Factor: TCF-1; motif: ACATCGRGRCGCTGW; match class: 1 0.0360611758175871 13184 134 108 0.805970149253731 0.00819174757281553
TF TF:M00982_1 Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 0.0377947944703973 3518 132 40 0.303030303030303 0.0113700966458215
TF TF:M01259 Factor: CTCF; motif: NNNNNNCCASNAGRKGGCRS 0.0383372918548717 1968 75 18 0.24 0.00914634146341463
TF TF:M12152_1 Factor: Sp1; motif: NWRGCCACGCCCMCN; match class: 1 0.0391114569594121 2859 125 33 0.264 0.0115424973767051
TF TF:M01588 Factor: GKLF; motif: GCCMCRCCCNNN 0.0391114569594121 8944 123 75 0.609756097560976 0.00838550983899821
TF TF:M02071 Factor: ETV7; motif: NCCGGAANNN 0.0415612180684141 10116 140 92 0.657142857142857 0.00909450375642546
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0423025425842266 7728 125 68 0.544 0.0087991718426501
TF TF:M12156 Factor: Sp2; motif: NTAAGYCCCGCCCMCTN 0.0423611043572132 4320 128 45 0.3515625 0.0104166666666667
TF TF:M09723_1 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 0.0423786823797751 6113 125 57 0.456 0.0093243906428922
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0423786823797751 6807 140 68 0.485714285714286 0.00998971646834141
TF TF:M09748 Factor: RAD21; motif: NCCASYAGRKGGCRSNN 0.0423851597186875 2016 75 18 0.24 0.00892857142857143
TF TF:M11531 Factor: E2F-2; motif: GCGCGCGCGYW 0.0423851597186875 13270 126 102 0.80952380952381 0.00768651092690279
TF TF:M12147_1 Factor: SP8; motif: RNCACGCCCMCN; match class: 1 0.0423851597186875 331 22 4 0.181818181818182 0.0120845921450151
TF TF:M00333_1 Factor: ZF5; motif: NRNGNGCGCGCWN; match class: 1 0.0423851597186875 12401 140 107 0.764285714285714 0.0086283364244819
TF TF:M01873_1 Factor: Egr-1; motif: GCGGGGGCGG; match class: 1 0.0423851597186875 2672 124 31 0.25 0.0116017964071856
TF TF:M11434 Factor: Elk-1; motif: NRSCGGAAGNN 0.0423851597186875 8219 129 73 0.565891472868217 0.00888185910694732
TF TF:M03914_1 Factor: KLF16; motif: GMCACGCCCCC; match class: 1 0.0458204889556757 710 123 13 0.105691056910569 0.0183098591549296
TF TF:M12153 Factor: Sp3; motif: NGCCACGCCCMCN 0.045991636798741 6205 132 60 0.454545454545455 0.0096696212731668
WP WP:WP4396 Nonalcoholic fatty liver disease 8.84794425917076e-07 159 93 14 0.150537634408602 0.0880503144654088
WP WP:WP111 Electron Transport Chain (OXPHOS system in mitochondria) 3.63649460313045e-05 105 93 10 0.10752688172043 0.0952380952380952
WP WP:WP4324 Mitochondrial complex I assembly model OXPHOS system 0.00021930618348669 56 93 7 0.0752688172043011 0.125
WP WP:WP623 Oxidative phosphorylation 0.000328559753723149 62 93 7 0.0752688172043011 0.112903225806452

pP11 transcription factor target enrichment of top program genes

TF enrichment of pP11
TFs corrosponding to activation of pP11. (Left) pearson correlation of TF expression and gene expression program activatity in Plasma cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.