pS16 program activity among Stromal cells

Activation of pS16
pS16 gene program activation in Stromal cells.
Gene program activation of pS16 by different cell subtypes
pS16 gene program activation among cells of different subtypes (Stromal cells).

pS16 top program genes

Top genes of pS16 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS16 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS16
pS16 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0010273 detoxification of copper ion 3.81983858213361e-18 14 22 8 0.363636363636364 0.571428571428571
GO:BP GO:1990169 stress response to copper ion 3.81983858213361e-18 14 22 8 0.363636363636364 0.571428571428571
GO:BP GO:0097501 stress response to metal ion 8.17411933616746e-18 16 22 8 0.363636363636364 0.5
GO:BP GO:0061687 detoxification of inorganic compound 8.17411933616746e-18 16 22 8 0.363636363636364 0.5
GO:BP GO:0071294 cellular response to zinc ion 2.47933907021604e-16 23 22 8 0.363636363636364 0.347826086956522
GO:BP GO:0071280 cellular response to copper ion 9.32938524145901e-16 27 22 8 0.363636363636364 0.296296296296296
GO:BP GO:0006882 cellular zinc ion homeostasis 1.2084698073866e-14 37 22 8 0.363636363636364 0.216216216216216
GO:BP GO:0071276 cellular response to cadmium ion 1.2084698073866e-14 37 22 8 0.363636363636364 0.216216216216216
GO:BP GO:0055069 zinc ion homeostasis 1.70942761597282e-14 39 22 8 0.363636363636364 0.205128205128205
GO:BP GO:0046688 response to copper ion 2.94541642481572e-14 42 22 8 0.363636363636364 0.19047619047619
GO:BP GO:0010043 response to zinc ion 2.73757516236113e-13 55 22 8 0.363636363636364 0.145454545454545
GO:BP GO:0046686 response to cadmium ion 1.03314000703607e-12 65 22 8 0.363636363636364 0.123076923076923
GO:BP GO:0046916 cellular transition metal ion homeostasis 1.08058011164194e-12 116 22 9 0.409090909090909 0.0775862068965517
GO:BP GO:0098754 detoxification 3.79480995774141e-12 134 22 9 0.409090909090909 0.0671641791044776
GO:BP GO:0055076 transition metal ion homeostasis 4.64083545248989e-12 138 22 9 0.409090909090909 0.0652173913043478
GO:BP GO:0045926 negative regulation of growth 2.04664713889405e-11 255 22 10 0.454545454545455 0.0392156862745098
GO:BP GO:0071248 cellular response to metal ion 8.3332025393043e-11 192 22 9 0.409090909090909 0.046875
GO:BP GO:0071241 cellular response to inorganic substance 2.69658085382053e-10 220 22 9 0.409090909090909 0.0409090909090909
GO:BP GO:0009636 response to toxic substance 6.25693689163765e-10 243 22 9 0.409090909090909 0.037037037037037
GO:BP GO:0010038 response to metal ion 1.86997542595296e-08 371 15 8 0.533333333333333 0.0215633423180593
GO:BP GO:0055080 cation homeostasis 2.89266270958792e-08 750 22 11 0.5 0.0146666666666667
GO:BP GO:0098771 inorganic ion homeostasis 3.22373293577338e-08 761 22 11 0.5 0.0144546649145861
GO:BP GO:0010035 response to inorganic substance 4.39360469996674e-08 575 22 10 0.454545454545455 0.0173913043478261
GO:BP GO:0050801 ion homeostasis 5.45360004392724e-08 808 22 11 0.5 0.0136138613861386
GO:BP GO:0006875 cellular metal ion homeostasis 5.45360004392724e-08 593 22 10 0.454545454545455 0.0168634064080944
GO:BP GO:0055065 metal ion homeostasis 1.63729534808817e-07 667 22 10 0.454545454545455 0.0149925037481259
GO:BP GO:0030003 cellular cation homeostasis 1.71899197505892e-07 673 22 10 0.454545454545455 0.0148588410104012
GO:BP GO:0040008 regulation of growth 1.85774174806359e-07 681 22 10 0.454545454545455 0.0146842878120411
GO:BP GO:0006873 cellular ion homeostasis 1.95197734710833e-07 687 22 10 0.454545454545455 0.0145560407569141
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 2.26869875913068e-07 497 22 9 0.409090909090909 0.0181086519114688
GO:BP GO:0048878 chemical homeostasis 2.28197083102614e-07 1229 22 12 0.545454545454545 0.00976403580146461
GO:BP GO:0042592 homeostatic process 2.42636667348969e-07 1981 16 12 0.75 0.0060575466935891
GO:BP GO:0072507 divalent inorganic cation homeostasis 2.86249429989066e-07 516 22 9 0.409090909090909 0.0174418604651163
GO:BP GO:0070887 cellular response to chemical stimulus 8.86771734222428e-07 3393 23 17 0.739130434782609 0.00501031535514294
GO:BP GO:0055082 cellular chemical homeostasis 1.12387952375513e-06 841 22 10 0.454545454545455 0.0118906064209275
GO:BP GO:0040007 growth 4.10650894837625e-06 967 22 10 0.454545454545455 0.0103412616339193
GO:BP GO:0019725 cellular homeostasis 4.57570664494259e-06 981 22 10 0.454545454545455 0.0101936799184506
GO:BP GO:0006950 response to stress 5.99302091896063e-06 4170 24 18 0.75 0.00431654676258993
GO:BP GO:0048519 negative regulation of biological process 1.0014517068461e-05 5757 22 19 0.863636363636364 0.0033003300330033
GO:BP GO:0042221 response to chemical 0.000142737858781234 4781 23 17 0.739130434782609 0.00355574147667852
GO:BP GO:0034097 response to cytokine 0.000632463053325589 1226 29 10 0.344827586206897 0.00815660685154975
GO:BP GO:0065008 regulation of biological quality 0.000723494207860094 4131 16 12 0.75 0.00290486564996369
GO:BP GO:0046464 acylglycerol catabolic process 0.000826776923982697 48 58 4 0.0689655172413793 0.0833333333333333
GO:BP GO:0046461 neutral lipid catabolic process 0.000826776923982697 48 58 4 0.0689655172413793 0.0833333333333333
GO:BP GO:0030099 myeloid cell differentiation 0.00121131281427967 428 16 5 0.3125 0.0116822429906542
GO:BP GO:0071345 cellular response to cytokine stimulus 0.00121131281427967 1132 16 7 0.4375 0.00618374558303887
GO:BP GO:0050896 response to stimulus 0.00177844231457435 9407 24 22 0.916666666666667 0.00233868395875412
GO:BP GO:0051716 cellular response to stimulus 0.00270485220203751 7781 24 20 0.833333333333333 0.00257036370646446
GO:BP GO:0046320 regulation of fatty acid oxidation 0.00405430731284855 33 48 3 0.0625 0.0909090909090909
GO:BP GO:0046503 glycerolipid catabolic process 0.00406537490932311 74 58 4 0.0689655172413793 0.0540540540540541
GO:BP GO:0071310 cellular response to organic substance 0.00796954453414816 2776 16 9 0.5625 0.00324207492795389
GO:BP GO:0019433 triglyceride catabolic process 0.00994568031547941 38 58 3 0.0517241379310345 0.0789473684210526
GO:BP GO:0031063 regulation of histone deacetylation 0.0145916809436386 32 80 3 0.0375 0.09375
GO:BP GO:1903706 regulation of hemopoiesis 0.016204582438281 424 16 4 0.25 0.00943396226415094
GO:BP GO:1903131 mononuclear cell differentiation 0.0168142563216538 430 16 4 0.25 0.00930232558139535
GO:BP GO:0019221 cytokine-mediated signaling pathway 0.0180257661664976 810 16 5 0.3125 0.00617283950617284
GO:BP GO:0035987 endodermal cell differentiation 0.0219686244702372 45 68 3 0.0441176470588235 0.0666666666666667
GO:BP GO:0072001 renal system development 0.0249412630244053 302 65 6 0.0923076923076923 0.0198675496688742
GO:BP GO:0030097 hemopoiesis 0.0278130329058941 928 16 5 0.3125 0.00538793103448276
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 0.0278130329058941 1341 17 6 0.352941176470588 0.00447427293064877
GO:BP GO:0045637 regulation of myeloid cell differentiation 0.0278130329058941 263 14 3 0.214285714285714 0.0114068441064639
GO:BP GO:0045892 negative regulation of transcription, DNA-templated 0.0278130329058941 1337 17 6 0.352941176470588 0.00448765893792072
GO:BP GO:0010033 response to organic substance 0.0278130329058941 3412 16 9 0.5625 0.00263774912075029
GO:BP GO:0044242 cellular lipid catabolic process 0.0278130329058941 232 58 5 0.0862068965517241 0.021551724137931
GO:BP GO:0009952 anterior/posterior pattern specification 0.0278130329058941 211 64 5 0.078125 0.023696682464455
GO:BP GO:0050994 regulation of lipid catabolic process 0.0278130329058941 60 58 3 0.0517241379310345 0.05
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 0.0278130329058941 1339 17 6 0.352941176470588 0.00448095593726662
GO:BP GO:0002521 leukocyte differentiation 0.0296718535002897 550 16 4 0.25 0.00727272727272727
GO:BP GO:0060562 epithelial tube morphogenesis 0.0296718535002897 329 65 6 0.0923076923076923 0.0182370820668693
GO:BP GO:0006638 neutral lipid metabolic process 0.0296718535002897 142 58 4 0.0689655172413793 0.028169014084507
GO:BP GO:0006639 acylglycerol metabolic process 0.0296718535002897 141 58 4 0.0689655172413793 0.0283687943262411
GO:BP GO:0001706 endoderm formation 0.0296718535002897 54 68 3 0.0441176470588235 0.0555555555555556
GO:BP GO:0048534 hematopoietic or lymphoid organ development 0.0296718535002897 966 16 5 0.3125 0.005175983436853
GO:BP GO:0050789 regulation of biological process 0.0296718535002897 12091 23 22 0.956521739130435 0.00181953519146473
GO:BP GO:0090311 regulation of protein deacetylation 0.0316156719309738 48 80 3 0.0375 0.0625
GO:BP GO:0003002 regionalization 0.0321012877856284 338 65 6 0.0923076923076923 0.0177514792899408
GO:BP GO:0001655 urogenital system development 0.0321012877856284 337 65 6 0.0923076923076923 0.0178041543026706
GO:BP GO:0051253 negative regulation of RNA metabolic process 0.0342442967493602 1445 17 6 0.352941176470588 0.0041522491349481
GO:BP GO:0002520 immune system development 0.0342442967493602 1020 16 5 0.3125 0.00490196078431373
GO:BP GO:0035690 cellular response to drug 0.037748479072111 70 61 3 0.0491803278688525 0.0428571428571429
GO:BP GO:1902105 regulation of leukocyte differentiation 0.0405955801645813 288 16 3 0.1875 0.0104166666666667
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 0.0424470313805183 1548 17 6 0.352941176470588 0.00387596899224806
GO:BP GO:0010817 regulation of hormone levels 0.0485497885599161 536 80 8 0.1 0.0149253731343284
GO:CC GO:0005634 nucleus 0.0150235197482886 7592 17 15 0.882352941176471 0.00197576396206533
GO:CC GO:0043231 intracellular membrane-bounded organelle 0.0194967967625381 11296 17 17 1 0.00150495750708215
GO:MF GO:0008270 zinc ion binding 0.000329731526684848 833 6 5 0.833333333333333 0.00600240096038415
GO:MF GO:0046914 transition metal ion binding 0.000688894429514453 1111 6 5 0.833333333333333 0.0045004500450045
GO:MF GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 0.00864260074505329 312 16 4 0.25 0.0128205128205128
GO:MF GO:0001217 DNA-binding transcription repressor activity 0.00864260074505329 314 16 4 0.25 0.0127388535031847
GO:MF GO:0001216 DNA-binding transcription activator activity 0.0133891865291908 455 14 4 0.285714285714286 0.00879120879120879
GO:MF GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 0.0133891865291908 451 14 4 0.285714285714286 0.00886917960088692
GO:MF GO:0000987 cis-regulatory region sequence-specific DNA binding 0.0177741339665776 1209 78 14 0.179487179487179 0.0115798180314309
GO:MF GO:0008144 drug binding 0.020572189783117 65 48 3 0.0625 0.0461538461538462
GO:MF GO:0043167 ion binding 0.020572189783117 6057 22 15 0.681818181818182 0.00247647350173353
GO:MF GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding 0.0332874147538582 1190 78 13 0.166666666666667 0.0109243697478992
GO:MF GO:0000976 transcription regulatory region sequence-specific DNA binding 0.0380741590294101 1507 78 14 0.179487179487179 0.0092899800928998
GO:MF GO:0046872 metal ion binding 0.0380741590294101 4260 4 4 1 0.000938967136150235
GO:MF GO:0043565 sequence-specific DNA binding 0.0380741590294101 1673 78 15 0.192307692307692 0.00896592946802152
GO:MF GO:0043169 cation binding 0.0380741590294101 4351 4 4 1 0.000919328889910365
GO:MF GO:0005515 protein binding 0.0380741590294101 14767 24 24 1 0.00162524547978601
GO:MF GO:0003690 double-stranded DNA binding 0.0380741590294101 1664 78 15 0.192307692307692 0.00901442307692308
GO:MF GO:0001067 regulatory region nucleic acid binding 0.0380741590294101 1509 78 14 0.179487179487179 0.00927766732935719
GO:MF GO:1990837 sequence-specific double-stranded DNA binding 0.0380741590294101 1570 78 15 0.192307692307692 0.00955414012738853
GO:MF GO:0005319 lipid transporter activity 0.0413076695519801 167 76 4 0.0526315789473684 0.0239520958083832
GO:MF GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific 0.0413076695519801 1375 16 5 0.3125 0.00363636363636364
GO:MF GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding 0.0426183153477176 1408 16 5 0.3125 0.00355113636363636
GO:MF GO:0003700 DNA-binding transcription factor activity 0.0449282694395386 1441 16 5 0.3125 0.00346981263011797
KEGG KEGG:04978 Mineral absorption 1.70378421775668e-10 59 22 8 0.363636363636364 0.135593220338983
REAC REAC:R-HSA-5661231 Metallothioneins bind metals 3.6618276789786e-18 11 22 8 0.363636363636364 0.727272727272727
REAC REAC:R-HSA-5660526 Response to metal ions 3.32046511749937e-17 14 22 8 0.363636363636364 0.571428571428571
REAC REAC:R-HSA-8953897 Cellular responses to external stimuli 1.04030067950968e-06 560 15 9 0.6 0.0160714285714286
REAC REAC:R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 0.00121882626102798 110 16 4 0.25 0.0363636363636364
REAC REAC:R-HSA-9006931 Signaling by Nuclear Receptors 0.0121132362214113 255 14 4 0.285714285714286 0.0156862745098039
TF TF:M00650_1 Factor: MTF-1; motif: TBTGCACHCGGCCC; match class: 1 2.98565906582625e-08 24 15 5 0.333333333333333 0.208333333333333
TF TF:M10163 Factor: ZNF708; motif: GNNNAANAARNAGGYACAGC 0.00120532816986091 219 15 5 0.333333333333333 0.0228310502283105
TF TF:M08890_1 Factor: MYB; motif: NNAACTGN; match class: 1 0.00120532816986091 63 6 3 0.5 0.0476190476190476
TF TF:M01201_1 Factor: AR; motif: GGNACRNNRTGTWCT; match class: 1 0.00179769914321989 2129 8 7 0.875 0.00328792860497886
TF TF:M00481_1 Factor: AR; motif: GGTACANNRTGTTCT; match class: 1 0.00241445926222845 2295 8 7 0.875 0.00305010893246187
TF TF:M00650 Factor: MTF-1; motif: TBTGCACHCGGCCC 0.00284208719848723 816 4 4 1 0.00490196078431373
TF TF:M07341_1 Factor: TORC2; motif: TGGGCTKKD; match class: 1 0.00291715067258439 884 7 5 0.714285714285714 0.00565610859728507
TF TF:M08890 Factor: MYB; motif: NNAACTGN 0.0047408770243201 1355 22 9 0.409090909090909 0.00664206642066421
TF TF:M02088 Factor: E2A; motif: NRMCASCTGCNNN 0.0047408770243201 2871 10 8 0.8 0.00278648554510623
TF TF:M04903 Factor: HNF-4alpha; motif: AGTCCAAR 0.00613344301329249 6987 17 15 0.882352941176471 0.0021468441391155
TF TF:M10042_1 Factor: PR; motif: RGNACATTYTGTNCTN; match class: 1 0.0086230514807124 998 8 5 0.625 0.00501002004008016
TF TF:M10042 Factor: PR; motif: RGNACATTYTGTNCTN 0.00899256080066435 3203 8 7 0.875 0.00218545113955667
TF TF:M01119_1 Factor: Kaiso; motif: NTCCTGCNAN; match class: 1 0.00899256080066435 542 22 6 0.272727272727273 0.011070110701107
TF TF:M09941_1 Factor: GR; motif: RGNACANMNTGTNCY; match class: 1 0.0112526295036676 2046 8 6 0.75 0.00293255131964809
TF TF:M04453_1 Factor: AR; motif: RGGWACAYNGTGTWCYN; match class: 1 0.0234116102807557 3794 8 7 0.875 0.0018450184501845
TF TF:M09725 Factor: DREF; motif: CTYYCWCTTCCY 0.0234116102807557 7519 16 14 0.875 0.00186194972735736
TF TF:M09813_1 Factor: MYB; motif: NNCAACTGNN; match class: 1 0.025959639578879 979 6 4 0.666666666666667 0.00408580183861083
TF TF:M10085 Factor: RBPJK; motif: NSNSTGGGAAN 0.025959639578879 3436 11 8 0.727272727272727 0.00232828870779977
TF TF:M11846_1 Factor: GR; motif: RGWACATWAYGTWCY; match class: 1 0.0270216309980286 3998 8 7 0.875 0.00175087543771886
TF TF:M07340_1 Factor: TEF-1; motif: ACATTCCWSNN; match class: 1 0.0305380941792061 468 21 5 0.238095238095238 0.0106837606837607
TF TF:M04715 Factor: Oct-2; motif: ATTTGCA 0.0330912008974043 6381 28 19 0.678571428571429 0.00297758971947971
TF TF:M09625_1 Factor: GR; motif: RGNACANKNTGTNCY; match class: 1 0.0330912008974043 4205 8 7 0.875 0.00166468489892985
TF TF:M11849_1 Factor: MR; motif: NGNACRNNNYGTNCN; match class: 1 0.0348511930558879 4264 8 7 0.875 0.00164165103189493
TF TF:M12280_1 Factor: MTF-1; motif: NTTTTGCACACGGCNNN; match class: 1 0.0352771251609803 1485 5 4 0.8 0.00269360269360269
TF TF:M11849 Factor: MR; motif: NGNACRNNNYGTNCN 0.0353619676732459 4324 8 7 0.875 0.00161887141535615
TF TF:M04750_1 Factor: GR; motif: RGRACATTNTGTYC; match class: 1 0.0426195366997842 1704 8 5 0.625 0.00293427230046948
TF TF:M08402 Factor: POU2F1:PEA3; motif: ACCGGATATGCAN 0.0426195366997842 8519 10 10 1 0.00117384669562155
TF TF:M00279_1 Factor: MIF-1; motif: NNGTTGCWWGGYAACNGS; match class: 1 0.0426195366997842 5341 19 13 0.684210526315789 0.00243400112338513
TF TF:M04903_1 Factor: HNF-4alpha; motif: AGTCCAAR; match class: 1 0.0426195366997842 1534 23 8 0.347826086956522 0.00521512385919166
TF TF:M04619 Factor: MTF-1; motif: CCGNGTGCAV 0.0426195366997842 1167 3 3 1 0.0025706940874036
TF TF:M00146 Factor: HSF1; motif: AGAANRTTCN 0.0448467669982537 2678 6 5 0.833333333333333 0.00186706497386109
TF TF:M04218 Factor: MAFK; motif: NTGCTGANTCAGCRN 0.0455794391593621 261 10 3 0.3 0.0114942528735632
TF TF:M11344_1 Factor: MafF; motif: NTGCTGASTCAGCAN; match class: 1 0.0478193634966985 268 10 3 0.3 0.0111940298507463
TF TF:M00280 Factor: RFX1; motif: NNGTNRCNWRGYAACNN 0.0482255324442696 6402 25 17 0.68 0.00265542018119338
TF TF:M00447_1 Factor: AR; motif: AGWACATNWTGTTCT; match class: 1 0.0496050779122406 854 4 3 0.75 0.00351288056206089
TF TF:M11344 Factor: MafF; motif: NTGCTGASTCAGCAN 0.0496050779122406 278 10 3 0.3 0.0107913669064748
WP WP:WP3529 Zinc homeostasis 6.54904383001724e-12 37 22 8 0.363636363636364 0.216216216216216
WP WP:WP3286 Copper homeostasis 8.58048236034612e-11 54 22 8 0.363636363636364 0.148148148148148
WP WP:WP3584 MECP2 and Associated Rett Syndrome 0.01955709349689 72 16 3 0.1875 0.0416666666666667
WP WP:WP710 DNA Damage Response (only ATM dependent) 0.0399875775597372 114 16 3 0.1875 0.0263157894736842

pS16 transcription factor target enrichment of top program genes

TF enrichment of pS16
TFs corrosponding to activation of pS16. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.