pS01 program activity among Stromal cells

Activation of pS01
pS01 gene program activation in Stromal cells.
Gene program activation of pS01 by different cell subtypes
pS01 gene program activation among cells of different subtypes (Stromal cells).

pS01 top program genes

Top genes of pS01 program
Bar plots showing the top genes for each gene program, ranked by (left) unique weights, (right) raw weights.

pS01 gene-set enrichment of top program genes (using g-profiler)

GSEA wth gene profiler of pS01
pS01 gene-set enrichment summary using g-profiler webtool.
Source termID Name Padj Tsize Qsize Overlap Precision Recall
GO:BP GO:0003012 muscle system process 4.551062667454e-09 471 127 22 0.173228346456693 0.0467091295116773
GO:BP GO:0006936 muscle contraction 9.65844725012871e-07 364 127 17 0.133858267716535 0.0467032967032967
GO:BP GO:0044057 regulation of system process 0.000299351119995663 623 91 15 0.164835164835165 0.0240770465489567
GO:BP GO:0061061 muscle structure development 0.000299351119995663 645 127 18 0.141732283464567 0.027906976744186
GO:BP GO:0090257 regulation of muscle system process 0.000299351119995663 257 91 10 0.10989010989011 0.0389105058365759
GO:BP GO:0006941 striated muscle contraction 0.000299351119995663 180 69 8 0.115942028985507 0.0444444444444444
GO:BP GO:0003013 circulatory system process 0.000736711433533074 637 139 18 0.129496402877698 0.0282574568288854
GO:BP GO:0042692 muscle cell differentiation 0.000922856996608653 390 42 8 0.19047619047619 0.0205128205128205
GO:BP GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 0.00127974437432164 36 55 4 0.0727272727272727 0.111111111111111
GO:BP GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 0.00128847411863367 37 55 4 0.0727272727272727 0.108108108108108
GO:BP GO:0071478 cellular response to radiation 0.0018718063458808 196 13 4 0.307692307692308 0.0204081632653061
GO:BP GO:0035304 regulation of protein dephosphorylation 0.0018718063458808 146 125 8 0.064 0.0547945205479452
GO:BP GO:0070296 sarcoplasmic reticulum calcium ion transport 0.0018718063458808 43 55 4 0.0727272727272727 0.0930232558139535
GO:BP GO:0008016 regulation of heart contraction 0.00316424214430572 254 58 7 0.120689655172414 0.0275590551181102
GO:BP GO:0006812 cation transport 0.00336688418537892 1197 66 15 0.227272727272727 0.012531328320802
GO:BP GO:0008015 blood circulation 0.00336688418537892 553 91 12 0.131868131868132 0.0216998191681736
GO:BP GO:0043666 regulation of phosphoprotein phosphatase activity 0.00336688418537892 121 125 7 0.056 0.0578512396694215
GO:BP GO:0043500 muscle adaptation 0.00418115195437701 127 125 7 0.056 0.0551181102362205
GO:BP GO:0003018 vascular process in circulatory system 0.00418115195437701 256 139 10 0.0719424460431655 0.0390625
GO:BP GO:1903522 regulation of blood circulation 0.00425901652181373 301 74 8 0.108108108108108 0.026578073089701
GO:BP GO:0007507 heart development 0.00427265519186914 578 64 10 0.15625 0.0173010380622837
GO:BP GO:0051146 striated muscle cell differentiation 0.00444308744130677 289 127 10 0.078740157480315 0.0346020761245675
GO:BP GO:0060047 heart contraction 0.00444308744130677 288 58 7 0.120689655172414 0.0243055555555556
GO:BP GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 0.00472455732597917 25 49 3 0.0612244897959184 0.12
GO:BP GO:0003015 heart process 0.00492371834182788 298 58 7 0.120689655172414 0.023489932885906
GO:BP GO:0003008 system process 0.00549162906582913 2293 82 24 0.292682926829268 0.0104666375926734
GO:BP GO:0030239 myofibril assembly 0.00571125823605575 62 125 5 0.04 0.0806451612903226
GO:BP GO:0035296 regulation of tube diameter 0.00571125823605575 135 91 6 0.0659340659340659 0.0444444444444444
GO:BP GO:0035150 regulation of tube size 0.00571125823605575 136 91 6 0.0659340659340659 0.0441176470588235
GO:BP GO:0032413 negative regulation of ion transmembrane transporter activity 0.00571125823605575 81 49 4 0.0816326530612245 0.0493827160493827
GO:BP GO:0097746 blood vessel diameter maintenance 0.00571125823605575 135 91 6 0.0659340659340659 0.0444444444444444
GO:BP GO:0043502 regulation of muscle adaptation 0.00571125823605575 105 116 6 0.0517241379310345 0.0571428571428571
GO:BP GO:0030029 actin filament-based process 0.00571125823605575 808 130 17 0.130769230769231 0.021039603960396
GO:BP GO:0104004 cellular response to environmental stimulus 0.00578703070067923 339 13 4 0.307692307692308 0.0117994100294985
GO:BP GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 0.00578703070067923 30 49 3 0.0612244897959184 0.1
GO:BP GO:0071214 cellular response to abiotic stimulus 0.00578703070067923 339 13 4 0.307692307692308 0.0117994100294985
GO:BP GO:0060048 cardiac muscle contraction 0.00610946830371883 139 58 5 0.0862068965517241 0.0359712230215827
GO:BP GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 0.0063463528233018 32 49 3 0.0612244897959184 0.09375
GO:BP GO:0060306 regulation of membrane repolarization 0.0063463528233018 37 116 4 0.0344827586206897 0.108108108108108
GO:BP GO:0098655 cation transmembrane transport 0.00692213942775927 914 66 12 0.181818181818182 0.0131291028446389
GO:BP GO:0032410 negative regulation of transporter activity 0.00747044130892795 92 49 4 0.0816326530612245 0.0434782608695652
GO:BP GO:1901020 negative regulation of calcium ion transmembrane transporter activity 0.00753778728691848 35 49 3 0.0612244897959184 0.0857142857142857
GO:BP GO:0007517 muscle organ development 0.00773016878043547 333 127 10 0.078740157480315 0.03003003003003
GO:BP GO:0006942 regulation of striated muscle contraction 0.00775902316946658 95 49 4 0.0816326530612245 0.0421052631578947
GO:BP GO:0098662 inorganic cation transmembrane transport 0.00775902316946658 794 66 11 0.166666666666667 0.0138539042821159
GO:BP GO:1904063 negative regulation of cation transmembrane transport 0.00775902316946658 96 49 4 0.0816326530612245 0.0416666666666667
GO:BP GO:0035303 regulation of dephosphorylation 0.00775902316946658 217 125 8 0.064 0.0368663594470046
GO:BP GO:0045214 sarcomere organization 0.0103396542198282 41 125 4 0.032 0.0975609756097561
GO:BP GO:0007010 cytoskeleton organization 0.0103975584895623 1423 130 23 0.176923076923077 0.0161630358397751
GO:BP GO:0072359 circulatory system development 0.0103975584895623 1194 71 14 0.197183098591549 0.0117252931323283
GO:BP GO:0006873 cellular ion homeostasis 0.0111101375966551 687 55 9 0.163636363636364 0.0131004366812227
GO:BP GO:1903170 negative regulation of calcium ion transmembrane transport 0.0113051175589071 43 49 3 0.0612244897959184 0.0697674418604651
GO:BP GO:0035637 multicellular organismal signaling 0.0113051175589071 204 49 5 0.102040816326531 0.0245098039215686
GO:BP GO:0010921 regulation of phosphatase activity 0.011644526282843 180 125 7 0.056 0.0388888888888889
GO:BP GO:0086009 membrane repolarization 0.011644526282843 48 116 4 0.0344827586206897 0.0833333333333333
GO:BP GO:0019722 calcium-mediated signaling 0.011644526282843 211 49 5 0.102040816326531 0.023696682464455
GO:BP GO:0009314 response to radiation 0.011644526282843 461 13 4 0.307692307692308 0.00867678958785249
GO:BP GO:0007219 Notch signaling pathway 0.011644526282843 193 82 6 0.0731707317073171 0.0310880829015544
GO:BP GO:0048011 neurotrophin TRK receptor signaling pathway 0.011644526282843 32 70 3 0.0428571428571429 0.09375
GO:BP GO:0010035 response to inorganic substance 0.0123691665875151 575 11 4 0.363636363636364 0.00695652173913044
GO:BP GO:0060537 muscle tissue development 0.0129358055218626 399 42 6 0.142857142857143 0.0150375939849624
GO:BP GO:1904062 regulation of cation transmembrane transport 0.0132712249604606 360 66 7 0.106060606060606 0.0194444444444444
GO:BP GO:0098660 inorganic ion transmembrane transport 0.0132712249604606 883 66 11 0.166666666666667 0.0124575311438279
GO:BP GO:0002027 regulation of heart rate 0.0135336109903904 104 58 4 0.0689655172413793 0.0384615384615385
GO:BP GO:0006875 cellular metal ion homeostasis 0.014524150839453 593 55 8 0.145454545454545 0.0134907251264755
GO:BP GO:0051346 negative regulation of hydrolase activity 0.0147419636765293 470 125 11 0.088 0.0234042553191489
GO:BP GO:0034763 negative regulation of transmembrane transport 0.0147419636765293 132 49 4 0.0816326530612245 0.0303030303030303
GO:BP GO:0034766 negative regulation of ion transmembrane transport 0.0147419636765293 131 49 4 0.0816326530612245 0.0305343511450382
GO:BP GO:0038179 neurotrophin signaling pathway 0.0147419636765293 38 70 3 0.0428571428571429 0.0789473684210526
GO:BP GO:2001258 negative regulation of cation channel activity 0.0147419636765293 54 49 3 0.0612244897959184 0.0555555555555556
GO:BP GO:0098771 inorganic ion homeostasis 0.0147419636765293 761 55 9 0.163636363636364 0.011826544021025
GO:BP GO:0006874 cellular calcium ion homeostasis 0.0151001837847938 460 55 7 0.127272727272727 0.0152173913043478
GO:BP GO:0031032 actomyosin structure organization 0.0151001837847938 199 125 7 0.056 0.0351758793969849
GO:BP GO:0023052 signaling 0.015261908704528 6810 82 46 0.560975609756098 0.00675477239353891
GO:BP GO:0042391 regulation of membrane potential 0.0154716804901118 442 136 11 0.0808823529411765 0.0248868778280543
GO:BP GO:0051283 negative regulation of sequestering of calcium ion 0.0156330491648528 124 55 4 0.0727272727272727 0.032258064516129
GO:BP GO:0055074 calcium ion homeostasis 0.0156330491648528 472 55 7 0.127272727272727 0.0148305084745763
GO:BP GO:0051209 release of sequestered calcium ion into cytosol 0.0156330491648528 123 55 4 0.0727272727272727 0.032520325203252
GO:BP GO:0042310 vasoconstriction 0.0156330491648528 83 82 4 0.0487804878048781 0.0481927710843374
GO:BP GO:0007154 cell communication 0.0156330491648528 6829 82 46 0.560975609756098 0.00673597891345731
GO:BP GO:0051651 maintenance of location in cell 0.0158302798446175 223 55 5 0.0909090909090909 0.0224215246636771
GO:BP GO:0006470 protein dephosphorylation 0.0158302798446175 338 125 9 0.072 0.0266272189349112
GO:BP GO:0030036 actin cytoskeleton organization 0.0158302798446175 709 130 14 0.107692307692308 0.0197461212976023
GO:BP GO:0051282 regulation of sequestering of calcium ion 0.0158302798446175 126 55 4 0.0727272727272727 0.0317460317460317
GO:BP GO:1902430 negative regulation of amyloid-beta formation 0.0161022794955191 31 97 3 0.0309278350515464 0.0967741935483871
GO:BP GO:0071805 potassium ion transmembrane transport 0.0161022794955191 224 116 7 0.0603448275862069 0.03125
GO:BP GO:0071417 cellular response to organonitrogen compound 0.0161636101285859 666 139 14 0.100719424460432 0.021021021021021
GO:BP GO:0048738 cardiac muscle tissue development 0.0161636101285859 224 14 3 0.214285714285714 0.0133928571428571
GO:BP GO:0051208 sequestering of calcium ion 0.0162780280596657 130 55 4 0.0727272727272727 0.0307692307692308
GO:BP GO:2001257 regulation of cation channel activity 0.0162780280596657 190 66 5 0.0757575757575758 0.0263157894736842
GO:BP GO:0019932 second-messenger-mediated signaling 0.0162780280596657 327 59 6 0.101694915254237 0.018348623853211
GO:BP GO:0050801 ion homeostasis 0.0162780280596657 808 55 9 0.163636363636364 0.0111386138613861
GO:BP GO:0043266 regulation of potassium ion transport 0.0164482061117895 110 66 4 0.0606060606060606 0.0363636363636364
GO:BP GO:0007165 signal transduction 0.0164482061117895 6309 98 50 0.510204081632653 0.00792518624187668
GO:BP GO:0061337 cardiac conduction 0.0165002906747366 150 49 4 0.0816326530612245 0.0266666666666667
GO:BP GO:0034220 ion transmembrane transport 0.0165002906747366 1397 136 22 0.161764705882353 0.015748031496063
GO:BP GO:0043269 regulation of ion transport 0.0165002906747366 1379 129 21 0.162790697674419 0.0152284263959391
GO:BP GO:0072503 cellular divalent inorganic cation homeostasis 0.0165002906747366 497 55 7 0.127272727272727 0.0140845070422535
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 0.0168299968998024 360 55 6 0.109090909090909 0.0166666666666667
GO:BP GO:0051926 negative regulation of calcium ion transport 0.0168299968998024 66 49 3 0.0612244897959184 0.0454545454545455
GO:BP GO:0043086 negative regulation of catalytic activity 0.0171077908504718 851 125 15 0.12 0.0176263219741481
GO:BP GO:0055001 muscle cell development 0.0172582421558433 184 42 4 0.0952380952380952 0.0217391304347826
GO:BP GO:0055065 metal ion homeostasis 0.0172582421558433 667 55 8 0.145454545454545 0.0119940029985007
GO:BP GO:0055082 cellular chemical homeostasis 0.0172582421558433 841 55 9 0.163636363636364 0.0107015457788347
GO:BP GO:0048488 synaptic vesicle endocytosis 0.0172582421558433 63 122 4 0.0327868852459016 0.0634920634920635
GO:BP GO:1903169 regulation of calcium ion transmembrane transport 0.0172582421558433 158 49 4 0.0816326530612245 0.0253164556962025
GO:BP GO:0006119 oxidative phosphorylation 0.0172582421558433 151 132 6 0.0454545454545455 0.0397350993377483
GO:BP GO:0010927 cellular component assembly involved in morphogenesis 0.0172582421558433 107 125 5 0.04 0.0467289719626168
GO:BP GO:0032515 negative regulation of phosphoprotein phosphatase activity 0.0172582421558433 62 125 4 0.032 0.0645161290322581
GO:BP GO:0043501 skeletal muscle adaptation 0.0172582421558433 27 125 3 0.024 0.111111111111111
GO:BP GO:1902992 negative regulation of amyloid precursor protein catabolic process 0.0172582421558433 35 97 3 0.0309278350515464 0.0857142857142857
GO:BP GO:0140238 presynaptic endocytosis 0.0172582421558433 63 122 4 0.0327868852459016 0.0634920634920635
GO:BP GO:0051049 regulation of transport 0.0172582421558433 1809 129 25 0.193798449612403 0.0138197899391929
GO:BP GO:0006937 regulation of muscle contraction 0.0172582421558433 170 116 6 0.0517241379310345 0.0352941176470588
GO:BP GO:0099623 regulation of cardiac muscle cell membrane repolarization 0.0172582421558433 29 116 3 0.0258620689655172 0.103448275862069
GO:BP GO:0072507 divalent inorganic cation homeostasis 0.0172979979230572 516 55 7 0.127272727272727 0.0135658914728682
GO:BP GO:0030003 cellular cation homeostasis 0.0172979979230572 673 55 8 0.145454545454545 0.011887072808321
GO:BP GO:0034765 regulation of ion transmembrane transport 0.0176946150822185 583 129 12 0.0930232558139535 0.0205831903945112
GO:BP GO:0097553 calcium ion transmembrane import into cytosol 0.0181506000510692 145 55 4 0.0727272727272727 0.0275862068965517
GO:BP GO:0034762 regulation of transmembrane transport 0.0181779458323452 588 129 12 0.0930232558139535 0.0204081632653061
GO:BP GO:1901017 negative regulation of potassium ion transmembrane transporter activity 0.0181779458323452 31 116 3 0.0258620689655172 0.0967741935483871
GO:BP GO:0035556 intracellular signal transduction 0.0181779458323452 2772 64 20 0.3125 0.00721500721500722
GO:BP GO:0055002 striated muscle cell development 0.0183469234379135 111 125 5 0.04 0.045045045045045
GO:BP GO:1901016 regulation of potassium ion transmembrane transporter activity 0.0186073263772649 70 116 4 0.0344827586206897 0.0571428571428571
GO:BP GO:0006813 potassium ion transport 0.0191329918619833 249 116 7 0.0603448275862069 0.0281124497991968
GO:BP GO:0030001 metal ion transport 0.0192030419409481 514 129 11 0.0852713178294574 0.0214007782101167
GO:BP GO:0006816 calcium ion transport 0.0192030419409481 436 129 10 0.0775193798449612 0.0229357798165138
GO:BP GO:1990090 cellular response to nerve growth factor stimulus 0.0199082533669517 54 70 3 0.0428571428571429 0.0555555555555556
GO:BP GO:0055117 regulation of cardiac muscle contraction 0.0204575138619821 79 49 3 0.0612244897959184 0.0379746835443038
GO:BP GO:0010038 response to metal ion 0.0204575138619821 371 11 3 0.272727272727273 0.00808625336927224
GO:BP GO:0009628 response to abiotic stimulus 0.0207804240436288 1261 13 5 0.384615384615385 0.00396510705789056
GO:BP GO:1990089 response to nerve growth factor 0.0210138675841234 56 70 3 0.0428571428571429 0.0535714285714286
GO:BP GO:0055114 obsolete oxidation-reduction process 0.0212207047854616 745 135 14 0.103703703703704 0.0187919463087248
GO:BP GO:1901699 cellular response to nitrogen compound 0.0213469944913446 724 139 14 0.100719424460432 0.0193370165745856
GO:BP GO:0086003 cardiac muscle cell contraction 0.0213469944913446 75 116 4 0.0344827586206897 0.0533333333333333
GO:BP GO:0035308 negative regulation of protein dephosphorylation 0.0215221684577637 70 125 4 0.032 0.0571428571428571
GO:BP GO:1901380 negative regulation of potassium ion transmembrane transport 0.0217835975202224 35 116 3 0.0258620689655172 0.0857142857142857
GO:BP GO:0051716 cellular response to stimulus 0.0231826986280889 7781 82 49 0.597560975609756 0.00629739108083794
GO:BP GO:0051279 regulation of release of sequestered calcium ion into cytosol 0.0231826986280889 85 49 3 0.0612244897959184 0.0352941176470588
GO:BP GO:0060402 calcium ion transport into cytosol 0.0231826986280889 165 55 4 0.0727272727272727 0.0242424242424242
GO:BP GO:0010243 response to organonitrogen compound 0.0237210690642259 1085 139 18 0.129496402877698 0.0165898617511521
GO:BP GO:1901019 regulation of calcium ion transmembrane transporter activity 0.0246169669520356 88 49 3 0.0612244897959184 0.0340909090909091
GO:BP GO:0036465 synaptic vesicle recycling 0.0246169669520356 76 122 4 0.0327868852459016 0.0526315789473684
GO:BP GO:0051336 regulation of hydrolase activity 0.0246514179938027 1321 125 19 0.152 0.0143830431491294
GO:BP GO:0044092 negative regulation of molecular function 0.0246514179938027 1219 125 18 0.144 0.014766201804758
GO:BP GO:0055080 cation homeostasis 0.024796306564093 750 55 8 0.145454545454545 0.0106666666666667
GO:BP GO:0099622 cardiac muscle cell membrane repolarization 0.0266528995589118 39 116 3 0.0258620689655172 0.0769230769230769
GO:BP GO:0022900 electron transport chain 0.0274178049377565 180 132 6 0.0454545454545455 0.0333333333333333
GO:BP GO:0070588 calcium ion transmembrane transport 0.0275864177790521 320 129 8 0.062015503875969 0.025
GO:BP GO:0007204 positive regulation of cytosolic calcium ion concentration 0.0297925714842981 325 129 8 0.062015503875969 0.0246153846153846
GO:BP GO:0006939 smooth muscle contraction 0.0297925714842981 110 91 4 0.043956043956044 0.0363636363636364
GO:BP GO:0019229 regulation of vasoconstriction 0.0297925714842981 64 74 3 0.0405405405405405 0.046875
GO:BP GO:0097435 supramolecular fiber organization 0.0306037925447967 734 130 13 0.1 0.0177111716621253
GO:BP GO:1902003 regulation of amyloid-beta formation 0.030626810977275 50 97 3 0.0309278350515464 0.06
GO:BP GO:0060401 cytosolic calcium ion transport 0.030626810977275 186 55 4 0.0727272727272727 0.021505376344086
GO:BP GO:0043267 negative regulation of potassium ion transport 0.030626810977275 42 116 3 0.0258620689655172 0.0714285714285714
GO:BP GO:0019725 cellular homeostasis 0.0309369789412087 981 55 9 0.163636363636364 0.00917431192660551
GO:BP GO:0016310 phosphorylation 0.0309369789412087 2138 118 25 0.211864406779661 0.0116931711880262
GO:BP GO:0014812 muscle cell migration 0.0309369789412087 106 97 4 0.0412371134020619 0.0377358490566038
GO:BP GO:0055085 transmembrane transport 0.0311474556050599 1635 137 23 0.167883211678832 0.0140672782874618
GO:BP GO:0071495 cellular response to endogenous stimulus 0.032377660561213 1422 139 21 0.151079136690647 0.0147679324894515
GO:BP GO:0001508 action potential 0.0326184717053307 137 127 5 0.0393700787401575 0.0364963503649635
GO:BP GO:0010522 regulation of calcium ion transport into cytosol 0.0341285068703089 106 49 3 0.0612244897959184 0.0283018867924528
GO:BP GO:0003009 skeletal muscle contraction 0.0342327399939027 45 116 3 0.0258620689655172 0.0666666666666667
GO:BP GO:0099003 vesicle-mediated transport in synapse 0.0342327399939027 210 122 6 0.0491803278688525 0.0285714285714286
GO:BP GO:0032412 regulation of ion transmembrane transporter activity 0.0343496499900265 270 66 5 0.0757575757575758 0.0185185185185185
GO:BP GO:0065009 regulation of molecular function 0.034422447884142 3221 125 35 0.28 0.0108661906240298
GO:BP GO:1903530 regulation of secretion by cell 0.0354982751561187 588 129 11 0.0852713178294574 0.0187074829931973
GO:BP GO:1901379 regulation of potassium ion transmembrane transport 0.035616869181956 95 116 4 0.0344827586206897 0.0421052631578947
GO:BP GO:0070509 calcium ion import 0.0361490426114552 86 129 4 0.0310077519379845 0.0465116279069767
GO:BP GO:0051235 maintenance of location 0.0375542990809555 337 55 5 0.0909090909090909 0.0148367952522255
GO:BP GO:1902991 regulation of amyloid precursor protein catabolic process 0.0375542990809555 57 97 3 0.0309278350515464 0.0526315789473684
GO:BP GO:0048878 chemical homeostasis 0.0375542990809555 1229 55 10 0.181818181818182 0.0081366965012205
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 0.037684477334673 99 56 3 0.0535714285714286 0.0303030303030303
GO:BP GO:0022898 regulation of transmembrane transporter activity 0.0377834699391245 281 66 5 0.0757575757575758 0.0177935943060498
GO:BP GO:0042773 ATP synthesis coupled electron transport 0.0384708054445615 100 56 3 0.0535714285714286 0.03
GO:BP GO:0048013 ephrin receptor signaling pathway 0.0387291714030165 88 64 3 0.046875 0.0340909090909091
GO:BP GO:1901698 response to nitrogen compound 0.0387355383428671 1172 139 18 0.129496402877698 0.015358361774744
GO:BP GO:0050790 regulation of catalytic activity 0.0399950485772704 2545 125 29 0.232 0.0113948919449902
GO:BP GO:0034205 amyloid-beta formation 0.0399950485772704 59 97 3 0.0309278350515464 0.0508474576271186
GO:BP GO:0140353 lipid export from cell 0.0410080843674583 88 66 3 0.0454545454545455 0.0340909090909091
GO:BP GO:0060291 long-term synaptic potentiation 0.041280541155558 87 67 3 0.0447761194029851 0.0344827586206897
GO:BP GO:1990748 cellular detoxification 0.0418881702850237 113 52 3 0.0576923076923077 0.0265486725663717
GO:BP GO:1901700 response to oxygen-containing compound 0.0424457203854397 1739 8 4 0.5 0.00230017251293847
GO:BP GO:0006091 generation of precursor metabolites and energy 0.0424457203854397 538 69 7 0.101449275362319 0.0130111524163569
GO:BP GO:0090066 regulation of anatomical structure size 0.0436031659182185 518 91 8 0.0879120879120879 0.0154440154440154
GO:BP GO:0032409 regulation of transporter activity 0.0436031659182185 297 66 5 0.0757575757575758 0.0168350168350168
GO:BP GO:0009719 response to endogenous stimulus 0.0436926599803874 1683 139 23 0.165467625899281 0.0136660724896019
GO:BP GO:0030073 insulin secretion 0.0450987638548567 218 129 6 0.0465116279069767 0.0275229357798165
GO:BP GO:0031400 negative regulation of protein modification process 0.0450987638548567 578 138 11 0.0797101449275362 0.0190311418685121
GO:BP GO:0051896 regulation of protein kinase B signaling 0.0456025843770764 259 48 4 0.0833333333333333 0.0154440154440154
GO:BP GO:0097237 cellular response to toxic substance 0.0461742124450245 120 52 3 0.0576923076923077 0.025
GO:BP GO:0085029 extracellular matrix assembly 0.0461742124450245 47 133 3 0.0225563909774436 0.0638297872340425
GO:BP GO:0010951 negative regulation of endopeptidase activity 0.0472755675114494 253 113 6 0.0530973451327434 0.0237154150197628
GO:BP GO:0014897 striated muscle hypertrophy 0.0474288264555495 108 116 4 0.0344827586206897 0.037037037037037
GO:BP GO:0051924 regulation of calcium ion transport 0.0477550046561187 259 49 4 0.0816326530612245 0.0154440154440154
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 0.0477550046561187 289 132 7 0.053030303030303 0.0242214532871972
GO:BP GO:0006796 phosphate-containing compound metabolic process 0.0483001781766944 3087 125 33 0.264 0.010689990281827
GO:BP GO:0014896 muscle hypertrophy 0.0484902882652131 110 116 4 0.0344827586206897 0.0363636363636364
GO:BP GO:0086002 cardiac muscle cell action potential involved in contraction 0.0489382997788626 56 116 3 0.0258620689655172 0.0535714285714286
GO:BP GO:0032879 regulation of localization 0.0493295446098228 2872 66 19 0.287878787878788 0.00661559888579387
GO:BP GO:0022904 respiratory electron transport chain 0.0496414817324281 117 56 3 0.0535714285714286 0.0256410256410256
GO:BP GO:0051248 negative regulation of protein metabolic process 0.0497975826806865 1151 125 16 0.128 0.0139009556907037
GO:BP GO:0050879 multicellular organismal movement 0.0498270676494938 57 116 3 0.0258620689655172 0.0526315789473684
GO:BP GO:0050881 musculoskeletal movement 0.0498270676494938 57 116 3 0.0258620689655172 0.0526315789473684
GO:BP GO:0050435 amyloid-beta metabolic process 0.0498270676494938 68 97 3 0.0309278350515464 0.0441176470588235
GO:CC GO:0043292 contractile fiber 2.6514899285626e-06 240 125 13 0.104 0.0541666666666667
GO:CC GO:0016529 sarcoplasmic reticulum 3.98411501824572e-06 70 126 8 0.0634920634920635 0.114285714285714
GO:CC GO:0016528 sarcoplasm 5.2373378900936e-06 79 126 8 0.0634920634920635 0.10126582278481
GO:CC GO:0030016 myofibril 5.2373378900936e-06 231 125 12 0.096 0.051948051948052
GO:CC GO:0030018 Z disc 9.90062602080737e-06 126 125 9 0.072 0.0714285714285714
GO:CC GO:0030017 sarcomere 9.90062602080737e-06 208 125 11 0.088 0.0528846153846154
GO:CC GO:0033017 sarcoplasmic reticulum membrane 1.59039016790676e-05 41 126 6 0.0476190476190476 0.146341463414634
GO:CC GO:0031674 I band 1.71991138873227e-05 139 125 9 0.072 0.0647482014388489
GO:CC GO:0005737 cytoplasm 6.59911112954421e-05 11911 132 108 0.818181818181818 0.0090672487616489
GO:CC GO:0005746 mitochondrial respirasome 0.00144186179078425 89 132 6 0.0454545454545455 0.0674157303370786
GO:CC GO:0070469 respirasome 0.00257359582155459 103 132 6 0.0454545454545455 0.058252427184466
GO:CC GO:0031975 envelope 0.00257359582155459 1237 138 22 0.159420289855072 0.0177849636216653
GO:CC GO:0031967 organelle envelope 0.00257359582155459 1237 138 22 0.159420289855072 0.0177849636216653
GO:CC GO:0031966 mitochondrial membrane 0.00300702781883122 746 138 16 0.115942028985507 0.0214477211796247
GO:CC GO:0015629 actin cytoskeleton 0.00368720304484813 513 43 7 0.162790697674419 0.01364522417154
GO:CC GO:0016010 dystrophin-associated glycoprotein complex 0.00464195636853398 19 116 3 0.0258620689655172 0.157894736842105
GO:CC GO:0090665 glycoprotein complex 0.00464195636853398 19 116 3 0.0258620689655172 0.157894736842105
GO:CC GO:0005740 mitochondrial envelope 0.0049682579081237 797 138 16 0.115942028985507 0.0200752823086575
GO:CC GO:0070062 extracellular exosome 0.00571899527856165 2176 17 8 0.470588235294118 0.00367647058823529
GO:CC GO:0030054 cell junction 0.00620398947453124 2105 68 18 0.264705882352941 0.00855106888361045
GO:CC GO:1903561 extracellular vesicle 0.00621172493868422 2261 17 8 0.470588235294118 0.00353825740822645
GO:CC GO:0043230 extracellular organelle 0.00621172493868422 2263 17 8 0.470588235294118 0.00353513035793195
GO:CC GO:0099080 supramolecular complex 0.00658697914214309 1323 125 20 0.16 0.0151171579743008
GO:CC GO:1902495 transmembrane transporter complex 0.00893793243547419 325 136 9 0.0661764705882353 0.0276923076923077
GO:CC GO:0099081 supramolecular polymer 0.011442453251398 1001 125 16 0.128 0.015984015984016
GO:CC GO:0099512 supramolecular fiber 0.011442453251398 993 125 16 0.128 0.0161127895266868
GO:CC GO:1990351 transporter complex 0.011442453251398 340 136 9 0.0661764705882353 0.0264705882352941
GO:CC GO:0048471 perinuclear region of cytoplasm 0.011442453251398 735 122 13 0.10655737704918 0.017687074829932
GO:CC GO:0031982 vesicle 0.011442453251398 4055 17 10 0.588235294117647 0.00246609124537608
GO:CC GO:0034703 cation channel complex 0.011442453251398 227 129 7 0.0542635658914729 0.0308370044052863
GO:CC GO:0008076 voltage-gated potassium channel complex 0.011442453251398 90 91 4 0.043956043956044 0.0444444444444444
GO:CC GO:0098796 membrane protein complex 0.0137522679896602 1322 136 20 0.147058823529412 0.0151285930408472
GO:CC GO:0030140 trans-Golgi network transport vesicle 0.0137954251635887 33 122 3 0.0245901639344262 0.0909090909090909
GO:CC GO:0005622 intracellular anatomical structure 0.013941211832199 14790 45 43 0.955555555555556 0.00290736984448952
GO:CC GO:0034705 potassium channel complex 0.0145184612101627 100 91 4 0.043956043956044 0.04
GO:CC GO:0034702 ion channel complex 0.0153701132174821 302 136 8 0.0588235294117647 0.0264900662251656
GO:CC GO:0070161 anchoring junction 0.0153701132174821 836 62 9 0.145161290322581 0.0107655502392345
GO:CC GO:0005887 integral component of plasma membrane 0.0155818626101066 1645 137 23 0.167883211678832 0.0139817629179331
GO:CC GO:0005615 extracellular space 0.0161476193042608 3594 20 10 0.5 0.00278241513633834
GO:CC GO:0098803 respiratory chain complex 0.0184869317431721 86 56 3 0.0535714285714286 0.0348837209302326
GO:CC GO:0042383 sarcolemma 0.0184869317431721 140 122 5 0.040983606557377 0.0357142857142857
GO:CC GO:0005743 mitochondrial inner membrane 0.0229600901753766 503 132 10 0.0757575757575758 0.0198807157057654
GO:CC GO:0031226 intrinsic component of plasma membrane 0.0240616908177272 1726 137 23 0.167883211678832 0.0133256083429896
GO:CC GO:0036477 somatodendritic compartment 0.0298640701022862 871 137 14 0.102189781021898 0.0160734787600459
GO:CC GO:0005856 cytoskeleton 0.0298640701022862 2332 130 27 0.207692307692308 0.0115780445969125
GO:CC GO:0043229 intracellular organelle 0.031326685178661 12491 45 38 0.844444444444444 0.00304219037707149
GO:CC GO:0062023 collagen-containing extracellular matrix 0.0326134597616671 421 16 3 0.1875 0.00712589073634204
GO:CC GO:0097447 dendritic tree 0.0369679298277677 640 82 8 0.0975609756097561 0.0125
GO:CC GO:0030425 dendrite 0.0369679298277677 638 82 8 0.0975609756097561 0.0125391849529781
GO:CC GO:0019866 organelle inner membrane 0.0369679298277677 564 132 10 0.0757575757575758 0.0177304964539007
GO:CC GO:0005771 multivesicular body 0.0417691987021052 62 122 3 0.0245901639344262 0.0483870967741935
GO:CC GO:0098797 plasma membrane protein complex 0.043178898389355 694 129 11 0.0852713178294574 0.015850144092219
GO:CC GO:0005739 mitochondrion 0.047168138312945 1673 56 11 0.196428571428571 0.00657501494321578
GO:CC GO:0098800 inner mitochondrial membrane protein complex 0.0481108083567829 146 56 3 0.0535714285714286 0.0205479452054795
GO:MF GO:0008092 cytoskeletal protein binding 4.60945881712246e-05 996 130 24 0.184615384615385 0.0240963855421687
GO:MF GO:0005030 neurotrophin receptor activity 5.39136474680736e-05 4 70 3 0.0428571428571429 0.75
GO:MF GO:0008307 structural constituent of muscle 0.000158909278102777 43 77 5 0.0649350649350649 0.116279069767442
GO:MF GO:0043121 neurotrophin binding 0.000558520356082434 9 70 3 0.0428571428571429 0.333333333333333
GO:MF GO:0019208 phosphatase regulator activity 0.000675918393849647 104 125 7 0.056 0.0673076923076923
GO:MF GO:0003779 actin binding 0.00134043838368878 448 130 13 0.1 0.0290178571428571
GO:MF GO:0042805 actinin binding 0.00646712104415809 38 42 3 0.0714285714285714 0.0789473684210526
GO:MF GO:0004129 cytochrome-c oxidase activity 0.0157176363180883 27 102 3 0.0294117647058824 0.111111111111111
GO:MF GO:0004857 enzyme inhibitor activity 0.0157176363180883 385 125 10 0.08 0.025974025974026
GO:MF GO:0015002 heme-copper terminal oxidase activity 0.0157176363180883 27 102 3 0.0294117647058824 0.111111111111111
GO:MF GO:0019888 protein phosphatase regulator activity 0.0157176363180883 89 125 5 0.04 0.0561797752808989
GO:MF GO:0016675 oxidoreductase activity, acting on a heme group of donors 0.0157176363180883 28 102 3 0.0294117647058824 0.107142857142857
GO:MF GO:0005516 calmodulin binding 0.0157176363180883 204 81 6 0.0740740740740741 0.0294117647058824
GO:MF GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor 0.0157176363180883 27 102 3 0.0294117647058824 0.111111111111111
GO:MF GO:0016247 channel regulator activity 0.0301596846981986 149 58 4 0.0689655172413793 0.0268456375838926
GO:MF GO:0016301 kinase activity 0.0301596846981986 796 114 13 0.114035087719298 0.0163316582914573
GO:MF GO:0030234 enzyme regulator activity 0.0312020508880275 1248 125 18 0.144 0.0144230769230769
GO:MF GO:0051015 actin filament binding 0.0312020508880275 212 109 6 0.055045871559633 0.0283018867924528
GO:MF GO:0019838 growth factor binding 0.0323823375331223 138 70 4 0.0571428571428571 0.0289855072463768
GO:MF GO:0005267 potassium channel activity 0.0368616866473115 125 40 3 0.075 0.024
GO:MF GO:0043014 alpha-tubulin binding 0.0368616866473115 41 123 3 0.024390243902439 0.0731707317073171
GO:MF GO:0019899 enzyme binding 0.0368616866473115 2074 118 24 0.203389830508475 0.0115718418514947
GO:MF GO:0016491 oxidoreductase activity 0.0368616866473115 771 45 7 0.155555555555556 0.00907911802853437
GO:MF GO:0022843 voltage-gated cation channel activity 0.0382665809952172 143 129 5 0.0387596899224806 0.034965034965035
GO:MF GO:0005246 calcium channel regulator activity 0.0382665809952172 45 116 3 0.0258620689655172 0.0666666666666667
GO:MF GO:0099106 ion channel regulator activity 0.0382665809952172 120 46 3 0.0652173913043478 0.025
GO:MF GO:0004864 protein phosphatase inhibitor activity 0.0400346689851248 46 125 3 0.024 0.0652173913043478
GO:MF GO:0009055 electron transfer activity 0.040334138798209 148 132 5 0.0378787878787879 0.0337837837837838
GO:MF GO:0019212 phosphatase inhibitor activity 0.0416671350731534 49 125 3 0.024 0.0612244897959184
GO:MF GO:0015075 ion transmembrane transporter activity 0.0416671350731534 956 137 15 0.109489051094891 0.0156903765690377
GO:MF GO:0015079 potassium ion transmembrane transporter activity 0.0432092114649174 161 40 3 0.075 0.0186335403726708
GO:MF GO:0016772 transferase activity, transferring phosphorus-containing groups 0.0454591331244031 952 114 13 0.114035087719298 0.0136554621848739
TF TF:M01100 Factor: LRF; motif: GGGGKYNNB 3.52638030645388e-05 7557 139 87 0.62589928057554 0.0115125049622866
TF TF:M09984_1 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG; match class: 1 0.00287096842549709 5555 140 66 0.471428571428571 0.0118811881188119
TF TF:M01100_1 Factor: LRF; motif: GGGGKYNNB; match class: 1 0.00287096842549709 2762 137 41 0.299270072992701 0.0148443157132513
TF TF:M09862 Factor: ZNF614; motif: NCYCWGCCYYNNN 0.00881506592930687 9361 141 93 0.659574468085106 0.00993483602179254
TF TF:M09723_1 Factor: BTEB1; motif: GGGGGCGGGGCNGSGGGNGS; match class: 1 0.00881506592930687 6113 141 69 0.48936170212766 0.0112874202519221
TF TF:M12158 Factor: KLF15; motif: NCCMCGCCCMCN 0.0170757983959875 11088 141 103 0.730496453900709 0.00928932178932179
TF TF:M09993 Factor: MyoD; motif: NCAGCTGYYNCNNNC 0.0170757983959875 1169 113 19 0.168141592920354 0.0162532078699743
TF TF:M12180_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0170757983959875 248 127 9 0.0708661417322835 0.0362903225806452
TF TF:M12179_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0170757983959875 134 127 7 0.0551181102362205 0.0522388059701493
TF TF:M07218 Factor: MEF-2A; motif: NKCTAAAAATAGMNN 0.0170757983959875 311 36 6 0.166666666666667 0.0192926045016077
TF TF:M09658 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS 0.0170757983959875 5262 141 60 0.425531914893617 0.0114025085518814
TF TF:M01857_1 Factor: AP-2alpha; motif: NGCCYSNNGSN; match class: 1 0.0170757983959875 4616 110 45 0.409090909090909 0.00974870017331022
TF TF:M07041 Factor: HDAC1; motif: KGCARGGTC 0.0170757983959875 12526 141 112 0.794326241134752 0.00894140188408111
TF TF:M01132_1 Factor: SF-1; motif: TGACCTTGN; match class: 1 0.0174111123758476 97 45 4 0.0888888888888889 0.0412371134020619
TF TF:M11824_1 Factor: SF-1; motif: NNCAAGGNCRN; match class: 1 0.0174111123758476 97 45 4 0.0888888888888889 0.0412371134020619
TF TF:M12351_1 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC; match class: 1 0.0174111123758476 8180 141 82 0.581560283687943 0.0100244498777506
TF TF:M04873_1 Factor: ERR1; motif: NTGACCTTGRNN; match class: 1 0.0174111123758476 310 45 6 0.133333333333333 0.0193548387096774
TF TF:M03947 Factor: GRHL1; motif: AAAACCGGTTTN 0.0174111123758476 69 19 3 0.157894736842105 0.0434782608695652
TF TF:M10026 Factor: PATZ; motif: GGGGNGGGGGMKGGRRNGGNRN 0.0174111123758476 8389 141 83 0.588652482269504 0.00989390868995113
TF TF:M10627 Factor: NKX3A; motif: NCCACTTANN 0.0174111123758476 2557 16 9 0.5625 0.00351974970668752
TF TF:M01303_1 Factor: SP1; motif: GGGGYGGGGNS; match class: 1 0.0174111123758476 3507 130 42 0.323076923076923 0.0119760479041916
TF TF:M09862_1 Factor: ZNF614; motif: NCYCWGCCYYNNN; match class: 1 0.0174111123758476 4193 130 47 0.361538461538462 0.0112091581206773
TF TF:M09738_1 Factor: ZNF511; motif: GGRRGRGGCWGNG; match class: 1 0.0174111123758476 4738 138 54 0.391304347826087 0.011397214014352
TF TF:M07261_1 Factor: LKLF; motif: GGGGTGGKSN; match class: 1 0.0174111123758476 4062 140 49 0.35 0.0120630231413097
TF TF:M12182_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0174111123758476 206 127 8 0.062992125984252 0.0388349514563107
TF TF:M00915_1 Factor: AP-2; motif: SNNNCCNCAGGCN; match class: 1 0.0174111123758476 4551 111 44 0.396396396396396 0.00966820479015601
TF TF:M07615 Factor: Sp3; motif: GGGGCGGGGSNN 0.0175265341990997 6807 141 71 0.50354609929078 0.0104304392537094
TF TF:M11595_1 Factor: GCMa; motif: RTGCGGGTN; match class: 1 0.0175265341990997 5786 122 56 0.459016393442623 0.00967853439336329
TF TF:M04456_1 Factor: ESRRA; motif: NTCAAGGTCAN; match class: 1 0.0175783152847979 100 45 4 0.0888888888888889 0.04
TF TF:M09970_1 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN; match class: 1 0.020868947918679 3783 141 46 0.326241134751773 0.0121596616441977
TF TF:M09985 Factor: Mef-2a; motif: NKCTATTTTTRGN 0.020868947918679 1454 8 5 0.625 0.00343878954607978
TF TF:M12150_1 Factor: SP9; motif: NCCACGCCCMCN; match class: 1 0.0214035738144673 294 127 9 0.0708661417322835 0.0306122448979592
TF TF:M03923 Factor: SP8; motif: RCCACGCCCMCY 0.0214035738144673 2843 38 15 0.394736842105263 0.00527611677805135
TF TF:M07402_1 Factor: ESRRA; motif: YCAAGGTCACN; match class: 1 0.0214035738144673 114 45 4 0.0888888888888889 0.0350877192982456
TF TF:M08284 Factor: Fli-1:FIGLA; motif: NCCGGAARCASSTGN 0.0214035738144673 7942 80 49 0.6125 0.00616973054646185
TF TF:M07129 Factor: Sp2; motif: GYCCCGCCYCYNNNN 0.0214035738144673 6260 141 66 0.468085106382979 0.0105431309904153
TF TF:M10071_1 Factor: Sp1; motif: NGGGGGCGGGGCCNGGGGGGGG; match class: 1 0.0214035738144673 4623 141 53 0.375886524822695 0.0114644170452087
TF TF:M12160_1 Factor: KLF15; motif: RCCMCRCCCMCN; match class: 1 0.0214035738144673 8031 109 64 0.587155963302752 0.00796911966131241
TF TF:M10072_1 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR; match class: 1 0.0214035738144673 6225 124 59 0.475806451612903 0.00947791164658635
TF TF:M01073 Factor: HIC1; motif: NNNGGKTGCCCSNNNNNN 0.0214035738144673 4088 140 48 0.342857142857143 0.0117416829745597
TF TF:M12149_1 Factor: SP9; motif: RCCACGCCCMCY; match class: 1 0.0219417186132419 300 127 9 0.0708661417322835 0.03
TF TF:M07039 Factor: ETF; motif: CCCCGCCCCYN 0.0228677181225286 16384 141 132 0.936170212765957 0.008056640625
TF TF:M11167 Factor: HEN1; motif: NGGNMKCAGCTGCGYCCC 0.0228677181225286 123 134 6 0.0447761194029851 0.0487804878048781
TF TF:M00006 Factor: MEF-2A; motif: CTCTAAAAATAACYCY 0.0228677181225286 1986 7 5 0.714285714285714 0.00251762336354481
TF TF:M11832_1 Factor: ERR1; motif: NNSAAGGTCRN; match class: 1 0.0228677181225286 121 45 4 0.0888888888888889 0.0330578512396694
TF TF:M10084_1 Factor: SF-1; motif: NYYCAAGGYCA; match class: 1 0.0228677181225286 552 73 9 0.123287671232877 0.016304347826087
TF TF:M09972 Factor: BTEB2; motif: WGGGTGKGGCNGGN 0.0228677181225286 9217 131 82 0.625954198473282 0.0088966041011175
TF TF:M08819_1 Factor: LKLF; motif: CNCCACCCS; match class: 1 0.0228677181225286 1532 140 24 0.171428571428571 0.0156657963446475
TF TF:M04595_1 Factor: SALL2; motif: GGGTGGG; match class: 1 0.0228677181225286 7373 101 56 0.554455445544555 0.0075952800759528
TF TF:M12160 Factor: KLF15; motif: RCCMCRCCCMCN 0.0228677181225286 12729 141 111 0.787234042553192 0.00872024510959227
TF TF:M12181_1 Factor: BTEB3; motif: NRCCACGCCCMCN; match class: 1 0.0228677181225286 183 127 7 0.0551181102362205 0.0382513661202186
TF TF:M05637 Factor: ZNF189; motif: KGTTGSGGGATY 0.0228677181225286 18 120 3 0.025 0.166666666666667
TF TF:M11825_1 Factor: SF-1; motif: NNCAAGGTCAN; match class: 1 0.0228677181225286 122 45 4 0.0888888888888889 0.0327868852459016
TF TF:M00407 Factor: RSRFC4; motif: ANKCTAWAAATAGMHYN 0.0241527432802242 1334 54 12 0.222222222222222 0.00899550224887556
TF TF:M10435 Factor: Sp2; motif: GGGGCGGGG 0.0249487283734265 7696 141 76 0.539007092198582 0.00987525987525988
TF TF:M08487_1 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG; match class: 1 0.0249487283734265 8790 141 84 0.595744680851064 0.00955631399317406
TF TF:M07063 Factor: Sp1; motif: GGGGCGGGGC 0.0249487283734265 7696 141 76 0.539007092198582 0.00987525987525988
TF TF:M07297 Factor: MAZ; motif: CCCTCCCYCYN 0.0249487283734265 2964 133 36 0.270676691729323 0.0121457489878543
TF TF:M11484_1 Factor: LBP-32; motif: NAACCGGTTN; match class: 1 0.025121746697716 129 19 3 0.157894736842105 0.0232558139534884
TF TF:M11484 Factor: LBP-32; motif: NAACCGGTTN 0.025121746697716 129 19 3 0.157894736842105 0.0232558139534884
TF TF:M10112_1 Factor: Miz-1; motif: NNRGGWGGGGGAGGGGMRR; match class: 1 0.025121746697716 4075 140 47 0.335714285714286 0.0115337423312883
TF TF:M09969_1 Factor: EKLF; motif: NGGGYGKGGCNNGG; match class: 1 0.0263220603437969 1489 138 23 0.166666666666667 0.0154466084620551
TF TF:M03948_1 Factor: TFCP2; motif: AAACCGGTTY; match class: 1 0.0268208680098237 134 19 3 0.157894736842105 0.0223880597014925
TF TF:M07329 Factor: Osx; motif: CCNCCCCCNNN 0.0268208680098237 6803 141 69 0.48936170212766 0.0101425841540497
TF TF:M00931_1 Factor: Sp1; motif: GGGGCGGGGC; match class: 1 0.0269787541554696 5905 141 62 0.439716312056738 0.0104995766299746
TF TF:M07461_1 Factor: KLF; motif: GGGNGGGG; match class: 1 0.0272366136997727 3397 127 38 0.299212598425197 0.0111863408890197
TF TF:M11012 Factor: islet1; motif: SCAMTTAN 0.0272524462422749 6170 12 10 0.833333333333333 0.00162074554294976
TF TF:M12354_1 Factor: ZNF37A; motif: CCYYGGCTCCNTSCCMN; match class: 1 0.0272524462422749 5624 139 59 0.424460431654676 0.0104907539118065
TF TF:M09987 Factor: MEF-2D; motif: NKCTATTTTTAG 0.0275914343709771 427 122 10 0.0819672131147541 0.0234192037470726
TF TF:M03553_1 Factor: KLF3; motif: CCMCACCCNG; match class: 1 0.0275914343709771 151 120 6 0.05 0.0397350993377483
TF TF:M09986 Factor: MEF-2C; motif: NKCTATTTTTRGN 0.0275914343709771 1072 122 17 0.139344262295082 0.0158582089552239
TF TF:M07338_1 Factor: Sox-10; motif: ACAAWGNN; match class: 1 0.0275914343709771 110 24 3 0.125 0.0272727272727273
TF TF:M09826_1 Factor: BTEB3; motif: CCNNSCCNSCCCCKCCCCC; match class: 1 0.0278842596559357 7508 141 74 0.524822695035461 0.00985615343633458
TF TF:M08906_1 Factor: TR4; motif: NCCCTGACCYB; match class: 1 0.0278842596559357 743 36 7 0.194444444444444 0.00942126514131898
TF TF:M01169 Factor: Ikaros; motif: KYTGGGAGGN 0.0305242566880577 503 87 9 0.103448275862069 0.0178926441351889
TF TF:M10132 Factor: ZNF257; motif: GNYCTTGCCTCW 0.0312573808661962 436 44 6 0.136363636363636 0.0137614678899083
TF TF:M12183 Factor: KLF14; motif: NRCCACRCCCMCN 0.0312573808661962 6878 141 69 0.48936170212766 0.0100319860424542
TF TF:M12154_1 Factor: Sp3; motif: NGCCACGCCCMCN; match class: 1 0.0317704790723513 274 127 8 0.062992125984252 0.0291970802919708
TF TF:M00966_1 Factor: VDR,; motif: RRTGNMCYTNNTGAMCCNYNT; match class: 1 0.0348074920224255 3238 122 35 0.286885245901639 0.0108091414453366
TF TF:M04934_1 Factor: TR4; motif: ACCCCGS; match class: 1 0.0348074920224255 15478 123 111 0.902439024390244 0.00717146918206487
TF TF:M03567 Factor: Sp2; motif: NYSGCCCCGCCCCCY 0.0348074920224255 7710 141 75 0.531914893617021 0.00972762645914397
TF TF:M10843 Factor: HOXD13; motif: NSYAATAAAAN 0.0348074920224255 968 4 3 0.75 0.00309917355371901
TF TF:M09765 Factor: SP1; motif: NRGKGGGCGGGGCN 0.038093952572573 7469 141 73 0.517730496453901 0.00977373142321596
TF TF:M03920_1 Factor: SP1; motif: RCCMCRCCCMC; match class: 1 0.0381867183128684 3020 141 37 0.26241134751773 0.0122516556291391
TF TF:M08487 Factor: GCMa:Erg; motif: ATGCGGGCGGAARKG 0.0381867183128684 13942 141 117 0.829787234042553 0.00839190933868885
TF TF:M11829_1 Factor: LRH-1; motif: NTCAAGGTCAN; match class: 1 0.0381867183128684 165 45 4 0.0888888888888889 0.0242424242424242
TF TF:M03868 Factor: CP2; motif: NTGNCTGGNN 0.0385481934449316 4722 25 14 0.56 0.00296484540448962
TF TF:M11826_1 Factor: LRH-1; motif: NTCAAGGTCRN; match class: 1 0.0385481934449316 166 45 4 0.0888888888888889 0.0240963855421687
TF TF:M01303 Factor: SP1; motif: GGGGYGGGGNS 0.0385481934449316 7898 141 76 0.539007092198582 0.00962268928842745
TF TF:M09638 Factor: MEF-2C; motif: NKCTATTTTTRGN 0.0385481934449316 1106 8 4 0.5 0.00361663652802893
TF TF:M04863_1 Factor: TF3C-beta; motif: CCNGGAGGGCTTCCTGGAGGAG; match class: 1 0.0385481934449316 8573 139 80 0.575539568345324 0.00933162253586842
TF TF:M07208 Factor: EGR1; motif: NCNCCGCCCCCGCN 0.0385481934449316 6183 141 63 0.446808510638298 0.0101892285298399
TF TF:M00982_1 Factor: KROX; motif: CCCGCCCCCRCCCC; match class: 1 0.0385481934449316 3518 140 41 0.292857142857143 0.011654349061967
TF TF:M02119_1 Factor: T3R-beta; motif: RRGNNANNNGAGGWCAN; match class: 1 0.0385481934449316 486 137 11 0.0802919708029197 0.0226337448559671
TF TF:M07054_1 Factor: P53; motif: NNNNNACAWGCCYNNN; match class: 1 0.0392522137151896 335 85 7 0.0823529411764706 0.0208955223880597
TF TF:M00109 Factor: C/EBPbeta; motif: RNRTKDNGMAAKNN 0.0394794496741688 3254 6 5 0.833333333333333 0.00153657037492317
TF TF:M09973 Factor: CPBP; motif: GNNRGGGHGGGGNNGGGRN 0.0394794496741688 10853 130 90 0.692307692307692 0.00829263798028195
TF TF:M09859_1 Factor: NF90; motif: NCCNCWGCCYCCNC; match class: 1 0.0394794496741688 1011 68 11 0.161764705882353 0.0108803165182987
TF TF:M09970 Factor: KLF3; motif: NNNNNNGGGCGGGGCNNGN 0.0394794496741688 7728 131 70 0.534351145038168 0.00905797101449275
TF TF:M05327_1 Factor: WT1; motif: NGCGGGGGGGTSMMCYN; match class: 1 0.0397283159575474 1757 133 24 0.180451127819549 0.0136596471257826
TF TF:M02000_1 Factor: ERR3; motif: CAAGGTCA; match class: 1 0.0415046874793209 177 45 4 0.0888888888888889 0.0225988700564972
TF TF:M11833_1 Factor: ERR1; motif: NNCAAGGTCAN; match class: 1 0.0415046874793209 76 45 3 0.0666666666666667 0.0394736842105263
TF TF:M00727_1 Factor: SF-1; motif: TGACCTTG; match class: 1 0.0415046874793209 177 45 4 0.0888888888888889 0.0225988700564972
TF TF:M11478 Factor: AP-2beta; motif: NSCCNNNGGSN 0.0415046874793209 9942 116 76 0.655172413793103 0.00764433715550191
TF TF:M11909 Factor: POU3F2; motif: NTATGCWAATKAG 0.0415331667609313 5127 19 12 0.631578947368421 0.00234055002925688
TF TF:M07277 Factor: BTEB2; motif: RGGGNGKGGN 0.0415857022594398 8492 141 80 0.567375886524823 0.00942063118228921
TF TF:M11827_1 Factor: LRH-1; motif: YGACCTTGNNNCAAGGTCR; match class: 1 0.0418791468241776 584 25 5 0.2 0.00856164383561644
TF TF:M02036 Factor: WT1; motif: CGCCCCCNCN 0.0429411583313601 9767 141 89 0.631205673758865 0.0091123169857684
TF TF:M00008 Factor: Sp1; motif: GGGGCGGGGT 0.0429411583313601 10055 141 91 0.645390070921986 0.00905022376926902
TF TF:M00453 Factor: IRF-7; motif: TNSGAAWNCGAAANTNNN 0.0437286494266111 3082 9 6 0.666666666666667 0.00194678780012979
TF TF:M08359_1 Factor: HOXD12:Elk-1; motif: NRNCGGAAGTCGTAAAN; match class: 1 0.0437286494266111 1166 4 3 0.75 0.00257289879931389
TF TF:M00196 Factor: Sp1; motif: NGGGGGCGGGGYN 0.0439830037526891 10233 141 92 0.652482269503546 0.00899052086387179
TF TF:M10560 Factor: Msx-2; motif: NTCRTTAN 0.0439830037526891 4570 9 7 0.777777777777778 0.00153172866520788
TF TF:M08962 Factor: PPARGAMMA:RXR-ALPHA; motif: NNRGGTCAAWAGGTCAN 0.0439830037526891 4787 117 44 0.376068376068376 0.00919156047628995
TF TF:M03802_1 Factor: SF-1; motif: NYCAAGGYCANNNN; match class: 1 0.0439830037526891 186 45 4 0.0888888888888889 0.021505376344086
TF TF:M02036_1 Factor: WT1; motif: CGCCCCCNCN; match class: 1 0.0439830037526891 5290 140 55 0.392857142857143 0.0103969754253308
TF TF:M11736 Factor: TLX; motif: NNAAGTCAN 0.0439830037526891 1797 6 4 0.666666666666667 0.00222593210907067
TF TF:M10589 Factor: BSX; motif: NTCRTTAN 0.0439830037526891 4570 9 7 0.777777777777778 0.00153172866520788
TF TF:M12351 Factor: TIEG1; motif: NCCCNSNCCCCGCCCCC 0.0439830037526891 12302 141 106 0.75177304964539 0.00861648512437002
TF TF:M07602_1 Factor: CP2; motif: NNNNCCAGNCNN; match class: 1 0.0439830037526891 4627 84 33 0.392857142857143 0.00713205100497082
TF TF:M10593 Factor: Dlx-6; motif: NTCRTTAN 0.0439830037526891 7158 7 7 1 0.000977926795194188
TF TF:M09977_1 Factor: Lyl-1; motif: NCAKCTGYTNYCNN; match class: 1 0.0439830037526891 7633 92 51 0.554347826086957 0.0066815144766147
TF TF:M11834_1 Factor: ERR1; motif: NTCAAGGTCAN; match class: 1 0.0449977841343815 84 45 3 0.0666666666666667 0.0357142857142857
TF TF:M02098_1 Factor: LRH-1; motif: NNYCAAGGYYN; match class: 1 0.0449977841343815 333 45 5 0.111111111111111 0.015015015015015
TF TF:M03807 Factor: SP2; motif: GNNGGGGGCGGGGSN 0.0449977841343815 8415 141 79 0.560283687943262 0.00938799762329174
TF TF:M09659 Factor: PU.1; motif: NRAAAGAGGAAGTGARA 0.0449977841343815 2523 18 8 0.444444444444444 0.00317082837891399
TF TF:M09602 Factor: ctcf; motif: NNNCCASYAGRKGGCRSYNN 0.0449977841343815 7450 139 71 0.510791366906475 0.00953020134228188
TF TF:M03893 Factor: WT1; motif: GNGGGGGCGGGG 0.0460773743834945 8290 141 78 0.553191489361702 0.00940892641737033
TF TF:M01858_1 Factor: AP-2beta; motif: GCNNNGGSCNGVGGGN; match class: 1 0.0463918202502246 3141 140 37 0.264285714285714 0.011779687997453
TF TF:M07436 Factor: WT1; motif: NNGGGNGGGSGN 0.0464587521681571 6182 109 50 0.458715596330275 0.00808799741184083
TF TF:M10836 Factor: HOXA13; motif: NCCAATAAAAN 0.0464587521681571 624 7 3 0.428571428571429 0.00480769230769231
TF TF:M10072 Factor: sp4; motif: NNGNARGRGGCGGRGCNNRR 0.0464587521681571 10494 135 90 0.666666666666667 0.00857632933104631
TF TF:M03922 Factor: SP4; motif: NWRGCCACGCCCMCTYN 0.046651615374418 6046 141 61 0.432624113475177 0.0100893152497519
TF TF:M04814 Factor: RelA-p65; motif: AAATCCCCT 0.0470310120270119 4528 124 44 0.354838709677419 0.00971731448763251
TF TF:M09636_1 Factor: MAZ; motif: GGGMGGGGSSGGGGGGGGGGGG; match class: 1 0.0475897301356522 14096 141 117 0.829787234042553 0.00830022701475596
TF TF:M03876 Factor: Kaiso; motif: GCMGGGRGCRGS 0.0476458860267374 13622 141 114 0.808510638297872 0.00836881515196006
TF TF:M03923_1 Factor: SP8; motif: RCCACGCCCMCY; match class: 1 0.0476458860267374 401 127 9 0.0708661417322835 0.0224438902743142
TF TF:M11839_1 Factor: ERR3; motif: NNSAAGGTCAN; match class: 1 0.0476458860267374 88 45 3 0.0666666666666667 0.0340909090909091
TF TF:M12313 Factor: ZNF460; motif: NNACNCCCCCCNN 0.0476458860267374 5825 138 58 0.420289855072464 0.00995708154506438
TF TF:M12085_1 Factor: ZNF501; motif: NNNCSACGCGAACAC; match class: 1 0.0476458860267374 2980 138 35 0.253623188405797 0.011744966442953
TF TF:M01588_1 Factor: GKLF; motif: GCCMCRCCCNNN; match class: 1 0.0476458860267374 3962 141 44 0.312056737588652 0.01110550227158
TF TF:M05752 Factor: ZNF57; motif: NCGGGGTGGKSA 0.0476458860267374 339 120 8 0.0666666666666667 0.023598820058997
TF TF:M09729_1 Factor: LUMAN; motif: CYCAGCYYCY; match class: 1 0.0476458860267374 4645 72 29 0.402777777777778 0.00624327233584499
TF TF:M09658_1 Factor: Sp2; motif: GGSNNGGGGGCGGGGCCNGNGS; match class: 1 0.0476458860267374 2033 141 27 0.191489361702128 0.0132808657156911
TF TF:M03542 Factor: COUP-TF1; motif: TGACCTY 0.0476458860267374 5242 45 22 0.488888888888889 0.00419687142312095
TF TF:M08963 Factor: NR1B1; motif: RAGGTCA 0.0476458860267374 5242 45 22 0.488888888888889 0.00419687142312095
TF TF:M08968 Factor: RXR-ALPHA; motif: RAGGTCA 0.0476458860267374 5242 45 22 0.488888888888889 0.00419687142312095
TF TF:M07395_1 Factor: Sp1; motif: NGGGGCGGGGN; match class: 1 0.0476458860267374 6334 141 63 0.446808510638298 0.00994632143984844
TF TF:M11849_1 Factor: MR; motif: NGNACRNNNYGTNCN; match class: 1 0.0476458860267374 4264 128 43 0.3359375 0.0100844277673546
TF TF:M03567_1 Factor: Sp2; motif: NYSGCCCCGCCCCCY; match class: 1 0.0483703152607812 3614 141 41 0.290780141843972 0.0113447703375761
TF TF:M09890 Factor: ctcf; motif: YGGCCACCAGRKGGCRSYN 0.0486074609858627 8479 139 78 0.561151079136691 0.00919919801863427
TF TF:M10956_1 Factor: isx; motif: NTCRTTAA; match class: 1 0.0486074609858627 3336 9 6 0.666666666666667 0.00179856115107914
TF TF:M12158_1 Factor: KLF15; motif: NCCMCGCCCMCN; match class: 1 0.0486074609858627 6004 140 60 0.428571428571429 0.00999333777481679
TF TF:M10529_1 Factor: Sp1; motif: RGGGMGGRGSNGGGG; match class: 1 0.0486074609858627 2816 99 26 0.262626262626263 0.00923295454545455
TF TF:M08952_1 Factor: NF-KAPPAB1; motif: NGGKRNTTYCCCN; match class: 1 0.0487741061170333 3457 134 38 0.283582089552239 0.0109921897599074
TF TF:M00807 Factor: Egr; motif: GTGGGSGCRRS 0.0487741061170333 4343 141 47 0.333333333333333 0.0108220124338015
TF TF:M04430 Factor: Prop-1; motif: TAATYNAATTA 0.0487741061170333 1015 5 3 0.6 0.00295566502463054
TF TF:M09984 Factor: MAZ; motif: GGGGGAGGGGGNGRGRRRGNRG 0.0487741061170333 9544 140 86 0.614285714285714 0.00901089689857502
TF TF:M01723_1 Factor: SATB1; motif: AKWAWTAAHGRYMNWW; match class: 1 0.0487741061170333 504 9 3 0.333333333333333 0.00595238095238095
TF TF:M01185_1 Factor: BCL-6; motif: WRCTTTCKAGGRAT; match class: 1 0.0496495967144565 1192 9 4 0.444444444444444 0.00335570469798658

pS01 transcription factor target enrichment of top program genes

TF enrichment of pS01
TFs corrosponding to activation of pS01. (Left) pearson correlation of TF expression and gene expression program activatity in Stromal cells, (right) negative log p-value for enrichment of TF binding sites among top uniqueness weighted genes for the gene program. Blue bars indicate significant TFs meeting the following criteria: FDR<0.1, overlap > 2, Corr. R > 0, permutation based p-value < 0.05.